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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MTG1 (NCBI Gene ID:92170)

Gene Summary

Gene Summary

Gene Information	Gene Name: MTG1
	Gene ID: 92170
	Gene Symbol	MTG1
	Gene ID	92170
	Gene Name	mitochondrial ribosome associated GTPase 1
	Synonyms	GTP\|GTPBP7
	Cytomap	10q26.3
	Type of Gene	protein-coding
	Description	mitochondrial ribosome-associated GTPase 1GTP-binding protein 7 (putative)mitochondrial GTPase 1 homolog
	Modification date	20200313
	UniProtAcc	Q9BT17

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0032543	Mitochondrial translation
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MTG1	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MTG1[title] AND translation [title] AND human.'

Gene	Title	PMID
MTG1	Human G-proteins, ObgH1 and Mtg1, associate with the large mitochondrial ribosome subunit and are involved in translation and assembly of respiratory complexes	23396448

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
STAD	MTG1	-1.43160368180665	0.018431528005749
LUSC	MTG1	-9.2533205847158	1.09583750788394e-07
LUAD	MTG1	-1.45502261953375	9.14904976982756e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MTG1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	MTG1	PSMD4	0.808075155	3.84E-12
DLBC	Cell metabolism gene	MTG1	TSTA3	0.808546553	3.65E-12
DLBC	Cell metabolism gene	MTG1	PSMB6	0.809177736	3.40E-12
DLBC	Cell metabolism gene	MTG1	PSMB3	0.812442935	2.38E-12
DLBC	Cell metabolism gene	MTG1	POLR2H	0.813790089	2.05E-12
DLBC	Cell metabolism gene	MTG1	MTX1	0.816402291	1.52E-12
DLBC	Cell metabolism gene	MTG1	OAZ1	0.82357345	6.61E-13
DLBC	Cell metabolism gene	MTG1	TIMM13	0.824775728	5.73E-13
DLBC	Cell metabolism gene	MTG1	ECHS1	0.836648693	1.31E-13
DLBC	IUPHAR	MTG1	PSMB6	0.809177736	3.40E-12
DLBC	IUPHAR	MTG1	MPDU1	0.813065113	2.22E-12
TGCT	TF	MTG1	ZNF511	0.854663391	1.08E-45
THYM	Cell metabolism gene	MTG1	LSM2	0.800098303	2.10E-28
THYM	Cell metabolism gene	MTG1	LSM4	0.80060349	1.84E-28
THYM	Cell metabolism gene	MTG1	SEC61G	0.804141134	7.03E-29
THYM	Cell metabolism gene	MTG1	TBCB	0.806272447	3.90E-29
THYM	Cell metabolism gene	MTG1	NOP56	0.806585746	3.58E-29
THYM	Cell metabolism gene	MTG1	FAU	0.807220078	3.00E-29
THYM	Cell metabolism gene	MTG1	PSME2	0.807410491	2.84E-29
THYM	Cell metabolism gene	MTG1	PSMB1	0.809672007	1.50E-29
THYM	Cell metabolism gene	MTG1	EXOSC5	0.810189502	1.30E-29
THYM	Cell metabolism gene	MTG1	FPGS	0.810649612	1.14E-29
THYM	Cell metabolism gene	MTG1	TALDO1	0.811263004	9.57E-30
THYM	Cell metabolism gene	MTG1	POLD4	0.812310636	7.08E-30
THYM	Cell metabolism gene	MTG1	DPM2	0.812878883	6.01E-30
THYM	Cell metabolism gene	MTG1	OAZ1	0.813771369	4.64E-30
THYM	Cell metabolism gene	MTG1	NME1	0.815047829	3.20E-30
THYM	Cell metabolism gene	MTG1	GUK1	0.815829833	2.55E-30
THYM	Cell metabolism gene	MTG1	PTGES2	0.816379164	2.17E-30
THYM	Cell metabolism gene	MTG1	DOHH	0.817184629	1.71E-30
THYM	Cell metabolism gene	MTG1	PSMC5	0.817212255	1.69E-30
THYM	Cell metabolism gene	MTG1	ATP5G1	0.818485739	1.16E-30
THYM	Cell metabolism gene	MTG1	TSTA3	0.81890923	1.02E-30
THYM	Cell metabolism gene	MTG1	TIMM17B	0.819129618	9.55E-31
THYM	Cell metabolism gene	MTG1	DGKZ	0.819348367	8.95E-31
THYM	Cell metabolism gene	MTG1	POLR2I	0.819771821	7.88E-31
THYM	Cell metabolism gene	MTG1	MVD	0.820541612	6.24E-31
THYM	Cell metabolism gene	MTG1	PGP	0.821392544	4.82E-31
THYM	Cell metabolism gene	MTG1	APRT	0.822230582	3.74E-31
THYM	Cell metabolism gene	MTG1	UROS	0.827781821	6.64E-32
THYM	Cell metabolism gene	MTG1	PSMD4	0.828115051	5.97E-32
THYM	Cell metabolism gene	MTG1	POLD2	0.829171175	4.27E-32
THYM	Cell metabolism gene	MTG1	DTYMK	0.830532123	2.76E-32
THYM	Cell metabolism gene	MTG1	PGLS	0.831643384	1.92E-32
THYM	Cell metabolism gene	MTG1	EBP	0.833684464	9.87E-33
THYM	Cell metabolism gene	MTG1	PSMD13	0.834050601	8.75E-33
THYM	Cell metabolism gene	MTG1	PHKG2	0.834342041	7.95E-33
THYM	Cell metabolism gene	MTG1	SLC27A5	0.835249858	5.88E-33
THYM	Cell metabolism gene	MTG1	NANS	0.839233787	1.53E-33
THYM	Cell metabolism gene	MTG1	TOMM40	0.839350191	1.47E-33
THYM	Cell metabolism gene	MTG1	GEMIN7	0.83963767	1.34E-33
THYM	Cell metabolism gene	MTG1	ITPA	0.841228862	7.72E-34
THYM	Cell metabolism gene	MTG1	HMOX2	0.841541586	6.93E-34
THYM	Cell metabolism gene	MTG1	TIMM10	0.841971309	5.97E-34
THYM	Cell metabolism gene	MTG1	SRM	0.843389294	3.63E-34
THYM	Cell metabolism gene	MTG1	PSMB7	0.843441484	3.57E-34
THYM	Cell metabolism gene	MTG1	PMPCA	0.852765847	1.20E-35
THYM	Cell metabolism gene	MTG1	MTX1	0.855026456	5.09E-36
THYM	Cell metabolism gene	MTG1	HMBS	0.856481588	2.91E-36
THYM	Cell metabolism gene	MTG1	PSMC3	0.856967466	2.41E-36
THYM	Cell metabolism gene	MTG1	ACOT8	0.858699229	1.22E-36
THYM	Cell metabolism gene	MTG1	ALG3	0.860219244	6.70E-37
THYM	Cell metabolism gene	MTG1	TIMM8B	0.864071036	1.41E-37
THYM	Cell metabolism gene	MTG1	SNRPD2	0.87220669	4.48E-39
THYM	Cell metabolism gene	MTG1	GMPPA	0.872433013	4.06E-39
THYM	Cell metabolism gene	MTG1	TIMM50	0.881727707	5.77E-41
THYM	Cell metabolism gene	MTG1	POLR2H	0.884653143	1.41E-41
THYM	Cell metabolism gene	MTG1	PSMB3	0.885341992	1.00E-41
THYM	Cell metabolism gene	MTG1	EXOSC4	0.887339262	3.71E-42
THYM	Cell metabolism gene	MTG1	TIMM13	0.890283843	8.30E-43
THYM	CGC	MTG1	ASPSCR1	0.821583735	4.55E-31
THYM	CGC	MTG1	TFPT	0.828148329	5.91E-32
THYM	CGC	MTG1	SDHAF2	0.841320634	7.48E-34
THYM	Epifactor	MTG1	C17orf49	0.809986707	1.38E-29
THYM	Epifactor	MTG1	EXOSC5	0.810189502	1.30E-29
THYM	Epifactor	MTG1	RRP8	0.816932874	1.84E-30
THYM	Epifactor	MTG1	ZGPAT	0.817556986	1.53E-30
THYM	Epifactor	MTG1	MBD3	0.817627133	1.50E-30
THYM	Epifactor	MTG1	ZNHIT1	0.818049436	1.32E-30
THYM	Epifactor	MTG1	LAS1L	0.818545572	1.14E-30
THYM	Epifactor	MTG1	RUVBL2	0.820508795	6.31E-31
THYM	Epifactor	MTG1	TFPT	0.828148329	5.91E-32
THYM	Epifactor	MTG1	PRPF31	0.846051857	1.41E-34
THYM	Epifactor	MTG1	PPP4C	0.853210009	1.01E-35
THYM	Epifactor	MTG1	PRMT1	0.855317371	4.55E-36
THYM	Epifactor	MTG1	TAF10	0.857212402	2.19E-36
THYM	Epifactor	MTG1	NOC2L	0.858408168	1.37E-36
THYM	Epifactor	MTG1	FBL	0.870905312	7.91E-39
THYM	Epifactor	MTG1	SIRT6	0.870992487	7.61E-39
THYM	Epifactor	MTG1	EXOSC4	0.887339262	3.71E-42
THYM	Epifactor	MTG1	BRMS1	0.89497113	6.97E-44
THYM	IUPHAR	MTG1	GPR137	0.806945976	3.24E-29
THYM	IUPHAR	MTG1	PSMB1	0.809672007	1.50E-29
THYM	IUPHAR	MTG1	PTGES2	0.816379164	2.17E-30
THYM	IUPHAR	MTG1	MVD	0.820541612	6.24E-31
THYM	IUPHAR	MTG1	MPDU1	0.824801852	1.69E-31
THYM	IUPHAR	MTG1	EGLN2	0.832234936	1.59E-32
THYM	IUPHAR	MTG1	PHKG2	0.834342041	7.95E-33
THYM	IUPHAR	MTG1	SLC27A5	0.835249858	5.88E-33
THYM	IUPHAR	MTG1	ATP6V0B	0.835549207	5.32E-33
THYM	IUPHAR	MTG1	FKBP1A	0.838916239	1.71E-33
THYM	IUPHAR	MTG1	HMOX2	0.841541586	6.93E-34
THYM	IUPHAR	MTG1	PRMT1	0.855317371	4.55E-36
THYM	IUPHAR	MTG1	SIRT6	0.870992487	7.61E-39
THYM	Kinase	MTG1	ADCK4	0.816259933	2.24E-30
THYM	Kinase	MTG1	PHKG2	0.834342041	7.95E-33
THYM	TF	MTG1	USF1	0.801076998	1.62E-28
THYM	TF	MTG1	RBCK1	0.803354205	8.72E-29
THYM	TF	MTG1	IRF3	0.809775456	1.46E-29
THYM	TF	MTG1	ZGPAT	0.817556986	1.53E-30
THYM	TF	MTG1	MBD3	0.817627133	1.50E-30
THYM	TF	MTG1	ZNF688	0.81900713	9.91E-31
THYM	TF	MTG1	ZNF668	0.821992407	4.02E-31
THYM	TF	MTG1	ZNF581	0.847093761	9.70E-35
THYM	TF	MTG1	ZNF787	0.854350886	6.58E-36
THYM	TF	MTG1	ZNF511	0.861642873	3.79E-37
THYM	TSG	MTG1	RTN4IP1	0.806914439	3.27E-29
THYM	TSG	MTG1	IRF3	0.809775456	1.46E-29
THYM	TSG	MTG1	NME1	0.815047829	3.20E-30
THYM	TSG	MTG1	ZNF668	0.821992407	4.02E-31
THYM	TSG	MTG1	STUB1	0.825479179	1.37E-31
THYM	TSG	MTG1	PYCARD	0.830962659	2.40E-32
THYM	TSG	MTG1	GADD45GIP1	0.840742633	9.14E-34
THYM	TSG	MTG1	SIRT6	0.870992487	7.61E-39
THYM	TSG	MTG1	TSSC4	0.871163834	7.07E-39
THYM	TSG	MTG1	BRMS1	0.89497113	6.97E-44
UCS	Cell metabolism gene	MTG1	LSM2	0.800098303	2.10E-28
UCS	Cell metabolism gene	MTG1	LSM4	0.80060349	1.84E-28
UCS	Cell metabolism gene	MTG1	SEC61G	0.804141134	7.03E-29
UCS	Cell metabolism gene	MTG1	TBCB	0.806272447	3.90E-29
UCS	Cell metabolism gene	MTG1	NOP56	0.806585746	3.58E-29
UCS	Cell metabolism gene	MTG1	FAU	0.807220078	3.00E-29
UCS	Cell metabolism gene	MTG1	PSME2	0.807410491	2.84E-29
UCS	Cell metabolism gene	MTG1	PSMB1	0.809672007	1.50E-29
UCS	Cell metabolism gene	MTG1	EXOSC5	0.810189502	1.30E-29
UCS	Cell metabolism gene	MTG1	FPGS	0.810649612	1.14E-29
UCS	Cell metabolism gene	MTG1	TALDO1	0.811263004	9.57E-30
UCS	Cell metabolism gene	MTG1	POLD4	0.812310636	7.08E-30
UCS	Cell metabolism gene	MTG1	DPM2	0.812878883	6.01E-30
UCS	Cell metabolism gene	MTG1	OAZ1	0.813771369	4.64E-30
UCS	Cell metabolism gene	MTG1	NME1	0.815047829	3.20E-30
UCS	Cell metabolism gene	MTG1	GUK1	0.815829833	2.55E-30
UCS	Cell metabolism gene	MTG1	PTGES2	0.816379164	2.17E-30
UCS	Cell metabolism gene	MTG1	DOHH	0.817184629	1.71E-30
UCS	Cell metabolism gene	MTG1	PSMC5	0.817212255	1.69E-30
UCS	Cell metabolism gene	MTG1	ATP5G1	0.818485739	1.16E-30
UCS	Cell metabolism gene	MTG1	TSTA3	0.81890923	1.02E-30
UCS	Cell metabolism gene	MTG1	TIMM17B	0.819129618	9.55E-31
UCS	Cell metabolism gene	MTG1	DGKZ	0.819348367	8.95E-31
UCS	Cell metabolism gene	MTG1	POLR2I	0.819771821	7.88E-31
UCS	Cell metabolism gene	MTG1	MVD	0.820541612	6.24E-31
UCS	Cell metabolism gene	MTG1	PGP	0.821392544	4.82E-31
UCS	Cell metabolism gene	MTG1	APRT	0.822230582	3.74E-31
UCS	Cell metabolism gene	MTG1	UROS	0.827781821	6.64E-32
UCS	Cell metabolism gene	MTG1	PSMD4	0.828115051	5.97E-32
UCS	Cell metabolism gene	MTG1	POLD2	0.829171175	4.27E-32
UCS	Cell metabolism gene	MTG1	DTYMK	0.830532123	2.76E-32
UCS	Cell metabolism gene	MTG1	PGLS	0.831643384	1.92E-32
UCS	Cell metabolism gene	MTG1	EBP	0.833684464	9.87E-33
UCS	Cell metabolism gene	MTG1	PSMD13	0.834050601	8.75E-33
UCS	Cell metabolism gene	MTG1	PHKG2	0.834342041	7.95E-33
UCS	Cell metabolism gene	MTG1	SLC27A5	0.835249858	5.88E-33
UCS	Cell metabolism gene	MTG1	NANS	0.839233787	1.53E-33
UCS	Cell metabolism gene	MTG1	TOMM40	0.839350191	1.47E-33
UCS	Cell metabolism gene	MTG1	GEMIN7	0.83963767	1.34E-33
UCS	Cell metabolism gene	MTG1	ITPA	0.841228862	7.72E-34
UCS	Cell metabolism gene	MTG1	HMOX2	0.841541586	6.93E-34
UCS	Cell metabolism gene	MTG1	TIMM10	0.841971309	5.97E-34
UCS	Cell metabolism gene	MTG1	SRM	0.843389294	3.63E-34
UCS	Cell metabolism gene	MTG1	PSMB7	0.843441484	3.57E-34
UCS	Cell metabolism gene	MTG1	PMPCA	0.852765847	1.20E-35
UCS	Cell metabolism gene	MTG1	MTX1	0.855026456	5.09E-36
UCS	Cell metabolism gene	MTG1	HMBS	0.856481588	2.91E-36
UCS	Cell metabolism gene	MTG1	PSMC3	0.856967466	2.41E-36
UCS	Cell metabolism gene	MTG1	ACOT8	0.858699229	1.22E-36
UCS	Cell metabolism gene	MTG1	ALG3	0.860219244	6.70E-37
UCS	Cell metabolism gene	MTG1	TIMM8B	0.864071036	1.41E-37
UCS	Cell metabolism gene	MTG1	SNRPD2	0.87220669	4.48E-39
UCS	Cell metabolism gene	MTG1	GMPPA	0.872433013	4.06E-39
UCS	Cell metabolism gene	MTG1	TIMM50	0.881727707	5.77E-41
UCS	Cell metabolism gene	MTG1	POLR2H	0.884653143	1.41E-41
UCS	Cell metabolism gene	MTG1	PSMB3	0.885341992	1.00E-41
UCS	Cell metabolism gene	MTG1	EXOSC4	0.887339262	3.71E-42
UCS	Cell metabolism gene	MTG1	TIMM13	0.890283843	8.30E-43
UCS	CGC	MTG1	ASPSCR1	0.821583735	4.55E-31
UCS	CGC	MTG1	TFPT	0.828148329	5.91E-32
UCS	CGC	MTG1	SDHAF2	0.841320634	7.48E-34
UCS	Epifactor	MTG1	C17orf49	0.809986707	1.38E-29
UCS	Epifactor	MTG1	EXOSC5	0.810189502	1.30E-29
UCS	Epifactor	MTG1	RRP8	0.816932874	1.84E-30
UCS	Epifactor	MTG1	ZGPAT	0.817556986	1.53E-30
UCS	Epifactor	MTG1	MBD3	0.817627133	1.50E-30
UCS	Epifactor	MTG1	ZNHIT1	0.818049436	1.32E-30
UCS	Epifactor	MTG1	LAS1L	0.818545572	1.14E-30
UCS	Epifactor	MTG1	RUVBL2	0.820508795	6.31E-31
UCS	Epifactor	MTG1	TFPT	0.828148329	5.91E-32
UCS	Epifactor	MTG1	PRPF31	0.846051857	1.41E-34
UCS	Epifactor	MTG1	PPP4C	0.853210009	1.01E-35
UCS	Epifactor	MTG1	PRMT1	0.855317371	4.55E-36
UCS	Epifactor	MTG1	TAF10	0.857212402	2.19E-36
UCS	Epifactor	MTG1	NOC2L	0.858408168	1.37E-36
UCS	Epifactor	MTG1	FBL	0.870905312	7.91E-39
UCS	Epifactor	MTG1	SIRT6	0.870992487	7.61E-39
UCS	Epifactor	MTG1	EXOSC4	0.887339262	3.71E-42
UCS	Epifactor	MTG1	BRMS1	0.89497113	6.97E-44
UCS	IUPHAR	MTG1	GPR137	0.806945976	3.24E-29
UCS	IUPHAR	MTG1	PSMB1	0.809672007	1.50E-29
UCS	IUPHAR	MTG1	PTGES2	0.816379164	2.17E-30
UCS	IUPHAR	MTG1	MVD	0.820541612	6.24E-31
UCS	IUPHAR	MTG1	MPDU1	0.824801852	1.69E-31
UCS	IUPHAR	MTG1	EGLN2	0.832234936	1.59E-32
UCS	IUPHAR	MTG1	PHKG2	0.834342041	7.95E-33
UCS	IUPHAR	MTG1	SLC27A5	0.835249858	5.88E-33
UCS	IUPHAR	MTG1	ATP6V0B	0.835549207	5.32E-33
UCS	IUPHAR	MTG1	FKBP1A	0.838916239	1.71E-33
UCS	IUPHAR	MTG1	HMOX2	0.841541586	6.93E-34
UCS	IUPHAR	MTG1	PRMT1	0.855317371	4.55E-36
UCS	IUPHAR	MTG1	SIRT6	0.870992487	7.61E-39
UCS	Kinase	MTG1	ADCK4	0.816259933	2.24E-30
UCS	Kinase	MTG1	PHKG2	0.834342041	7.95E-33
UCS	TF	MTG1	USF1	0.801076998	1.62E-28
UCS	TF	MTG1	RBCK1	0.803354205	8.72E-29
UCS	TF	MTG1	IRF3	0.809775456	1.46E-29
UCS	TF	MTG1	ZGPAT	0.817556986	1.53E-30
UCS	TF	MTG1	MBD3	0.817627133	1.50E-30
UCS	TF	MTG1	ZNF688	0.81900713	9.91E-31
UCS	TF	MTG1	ZNF668	0.821992407	4.02E-31
UCS	TF	MTG1	ZNF581	0.847093761	9.70E-35
UCS	TF	MTG1	ZNF787	0.854350886	6.58E-36
UCS	TF	MTG1	ZNF511	0.861642873	3.79E-37
UCS	TSG	MTG1	RTN4IP1	0.806914439	3.27E-29
UCS	TSG	MTG1	IRF3	0.809775456	1.46E-29
UCS	TSG	MTG1	NME1	0.815047829	3.20E-30
UCS	TSG	MTG1	ZNF668	0.821992407	4.02E-31
UCS	TSG	MTG1	STUB1	0.825479179	1.37E-31
UCS	TSG	MTG1	PYCARD	0.830962659	2.40E-32
UCS	TSG	MTG1	GADD45GIP1	0.840742633	9.14E-34
UCS	TSG	MTG1	SIRT6	0.870992487	7.61E-39
UCS	TSG	MTG1	TSSC4	0.871163834	7.07E-39
UCS	TSG	MTG1	BRMS1	0.89497113	6.97E-44

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	MTG1	GNA15	-1.15430784934725	0.000121572986245155
KIRP	MTG1	RAB11A	1.52821325962631	0.000147277489304543
KICH	MTG1	DNM1	1.8225947557234	0.000287055969238281
COAD	MTG1	GNA15	-2.51710413044039	0.000745445489883424
LIHC	MTG1	DOCK2	1.74093815658113	0.00176202511499206
COAD	MTG1	RAB11A	-2.39921072698545	0.0021815299987793
CHOL	MTG1	RAB11A	-3.66678799134057	0.00390625
STAD	MTG1	PLCB2	-3.96054635322187	0.0044123362749815
KICH	MTG1	RAB11A	1.79825930749283	0.00460463762283325
BRCA	MTG1	RAB7A	-1.88004147893159	0.00520010834415395
KICH	MTG1	MAPK8	-1.51329293934289	0.00672554969787598
THCA	MTG1	NGFR	1.77668830535957	0.0077987309442106
HNSC	MTG1	DNM1	-1.36549317441097	0.0120438377739447
THCA	MTG1	PLCB2	-1.17968678061544	0.0165532896967884
CHOL	MTG1	RAB7A	1.89982413982143	0.01953125
KICH	MTG1	DOCK2	-1.14006555289107	0.0393387079238892
KIRP	MTG1	RAB7A	-7.63843176194268	0.0413399673998356
UCEC	MTG1	DOCK2	1.10289397331236	0.046875
UCEC	MTG1	PLCB2	1.53477974633115	0.046875
HNSC	MTG1	RAB11A	-2.14258348178078	1.26861641547294e-06
LUAD	MTG1	PLCB2	-1.39041848057459	1.85622339362816e-05
KIRC	MTG1	GNA15	-1.72722375636508	2.54891161547424e-12
PRAD	MTG1	NGFR	-1.21638574722352	2.91952404061616e-06
KIRC	MTG1	MAPK8	-1.92076786620356	3.15846974004787e-09
BRCA	MTG1	RAB11A	2.11170261411049	3.50581981406914e-11
LUAD	MTG1	DNM1	-1.57344864751058	4.11637918366747e-07
PRAD	MTG1	RAB11A	1.15185241820425	6.68841890472086e-06
LUSC	MTG1	DOCK2	-2.77037474210448	7.57048857587633e-10
THCA	MTG1	MAPK8	-5.39070634578477	9.38064110141239e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MTG1

STRN4, ICT1, PRNP, APP, DOCK8, ISLR, EGFR, TRIP13, SSSCA1, CAMK2D, HSPD1, YBEY, MRPL12, BPNT1, GRPR, LRRK1, Dppa3, PICK1, ERICH1, KRT37, STX2, LOC102724334, C12orf65, C6orf203, AARS2, ACAD9, ACOT2, AFG3L2, ATP5F1, ATP5J, BCS1L, BOP1, C17orf80, ADCK4, CS, DAP3, DLAT, DLST, ECHS1, ELAC2, ETFA, FASTKD2, GADD45GIP1, GLS, GRSF1, GTPBP10, GTPBP3, HNRNPDL, IARS2, IBA57, LETM1, LONP1, LRPPRC, MALSU1, ME2, MMAB, RNMTL1, MRPL1, MRPL11, MRPL13, MRPL15, MRPL16, MRPL17, MRPL19, MRPL2, MRPL23, MRPL24, MRPL27, MRPL28, MRPL3, MRPL38, MRPL39, MRPL4, MRPL41, MRPL43, MRPL44, MRPL45, MRPL46, MRPL49, MRPL50, MRPL51, MRPL52, MRPL53, MRPL54, MRPL9, MRPS10, MRPS16, MRPS18B, MRPS2, MRPS22, MRPS23, MRPS24, MRPS25, MRPS26, MRPS27, MRPS28, MRPS30, MRPS31, MRPS33, MRPS34, MRPS35, MRPS5, MRPS6, MRPS7, MRPS9, MTIF2, NDUFA12, NDUFA2, NDUFA5, NDUFA9, NDUFAF2, NDUFAF4, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS8, NDUFV1, NDUFV3, NFS1, NIFK, NT5DC2, OAT, OGDH, PDHA1, PDHB, PDPR, PMPCA, PNPT1, POLDIP2, POLRMT, PREPL, PTCD3, TACO1, TIMM44, TRMT10C, TRMT61B, TSFM, VARS2, VWA8, PIPSL, HCST, FTL, UQCRFS1, SCGB2A2, CAMK2A, RBFOX2, Htatsf1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MTG1	chr10	135215667	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MTG1	STAD	chr10	135211971	135211971	A	-	Frame_Shift_Del	p.L105fs	8
MTG1	COAD	chr10	135233645	135233645	C	-	Frame_Shift_Del	p.H327fs	7
MTG1	UCEC	chr10	135233628	135233628	G	A	Missense_Mutation	p.D322N	4
MTG1	KIRP	chr10	135209749	135209750	-	GC	Frame_Shift_Ins	p.L87fs	3
MTG1	PAAD	chr10	135215660	135215660	A	G	Missense_Mutation		2
MTG1	ACC	chr10	135209699	135209699	G	T	Missense_Mutation	p.Q70H	2
MTG1	PAAD	chr10	135211958	135211958	A	C	Missense_Mutation		2
MTG1	ESCA	chr10	135209721	135209721	C	G	Missense_Mutation	p.H78D	2
MTG1	ESCA	chr10	135212714	135212714	G	T	Missense_Mutation	p.R135L	2
MTG1	LIHC	chr10	135211954	135211954	T	C	Silent		2
MTG1	BLCA	chr10	135213089	135213089	C	A	Silent		2
MTG1	UCEC	chr10	135209264	135209264	G	A	Missense_Mutation	p.E54K	2
MTG1	ESCA	chr10	135209721	135209721	C	G	Missense_Mutation		2
MTG1	UCEC	chr10	135212692	135212692	G	T	Nonsense_Mutation	p.E128*	2
MTG1	BRCA	chr10	135233665	135233665	C	A	Missense_Mutation	p.P334H	2
MTG1	UCEC	chr10	135212723	135212723	G	A	Missense_Mutation	p.R138Q	2
MTG1	UCEC	chr10	135215055	135215055	C	T	Silent	p.G178	2
MTG1	STAD	chr10	135209235	135209235	G	A	Missense_Mutation		2
MTG1	UCEC	chr10	135232995	135232995	A	G	Missense_Mutation	p.H255R	2
MTG1	UCEC	chr10	135233611	135233611	C	T	Missense_Mutation	p.S316F	2
MTG1	LUSC	chr10	135233567	135233567	A	T	Silent	p.A301A	1
MTG1	COAD	chr10	135209676	135209676	T	A	Missense_Mutation	p.S63T	1
MTG1	STAD	chr10	135233048	135233048	G	A	Missense_Mutation	p.A273T	1
MTG1	KIRP	chr10	135209677	135209677	C	T	Missense_Mutation	p.S63L	1
MTG1	UCS	chr10	135215056	135215056	G	A	Missense_Mutation		1
MTG1	ESCA	chr10	135207758	135207758	G	A	Missense_Mutation	p.A12T	1
MTG1	THYM	chr10	135233664	135233664	C	T	Missense_Mutation	p.P334S	1
MTG1	LIHC	chr10	135213074	135213074	G	A	Silent		1
MTG1	UCS	chr10	135215056	135215056	G	A	Missense_Mutation	p.E179K	1
MTG1	THYM	chr10	135209680	135209680	G	T	Missense_Mutation	p.G64V	1
MTG1	LIHC	chr10	135233566	135233566	C	T	Missense_Mutation		1
MTG1	ACC	chr10	135207754	135207754	C	G	Missense_Mutation	p.S10R	1
MTG1	PAAD	chr10	135233564	135233564	G	A	Silent		1
MTG1	UCEC	chr10	135209752	135209752	C	T	Missense_Mutation	p.A88V	1
MTG1	PAAD	chr10	135211958	135211958	A	C	Missense_Mutation	p.E101A	1
MTG1	ESCA	chr10	135207758	135207758	G	A	Missense_Mutation		1
MTG1	LIHC	chr10	135215725	135215725	A	G	Missense_Mutation	p.T216A	1
MTG1	BLCA	chr10	135213089	135213089	C	T	Silent	p.L159L	1
MTG1	PAAD	chr10	135233564	135233564	G	A	Silent	p.A300A	1
MTG1	LUAD	chr10	135233655	135233655	G	C	Missense_Mutation	p.E331Q	1
MTG1	PAAD	chr10	135215660	135215660	A	G	Missense_Mutation	p.E194G	1
MTG1	HNSC	chr10	135212703	135212703	G	C	Silent		1
MTG1	LUAD	chr10	135233639	135233639	G	T	Silent	p.R325R	1
MTG1	CESC	chr10	135233645	135233645	C	-	Frame_Shift_Del		1
MTG1	SKCM	chr10	135213098	135213098	C	T	Silent	p.S162S	1
MTG1	HNSC	chr10	135233650	135233650	C	T	Missense_Mutation		1
MTG1	LUAD	chr10	135213068	135213068	C	G	Silent	p.P152P	1
MTG1	COAD	chr10	135209682	135209682	C	T	Missense_Mutation	p.R65C	1
MTG1	HNSC	chr10	135212703	135212703	G	C	Silent	p.G131G	1
MTG1	LUAD	chr10	135209744	135209744	G	T	Missense_Mutation	p.M85I	1
MTG1	COAD	chr10	135233595	135233595	C	T	Missense_Mutation	p.R311C	1
MTG1	STAD	chr10	135209235	135209235	G	A	Missense_Mutation	p.S44N	1
MTG1	HNSC	chr10	135233650	135233650	C	T	Missense_Mutation	p.P329L	1
MTG1	LUSC	chr10	135209741	135209741	G	C	Missense_Mutation	p.K84N	1

Copy number variation (CNV) of MTG1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MTG1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
101461	N/A	BM145010	BCAT1	chr12	24990401	+	MTG1	chr10	135233984	-
101461	Non-Cancer	TCGA-BR-7851-11A	DPEP1	chr16	89680127	+	MTG1	chr10	135209217	+
87518	STAD	TCGA-HU-A4H0-01A	MTG1	chr10	135216277	+	GPR123	chr10	134940737	+
103233	STAD	TCGA-FP-8211-01A	MTG1	chr10	135216277	+	MGMT	chr10	131362043	+
101926	STAD	TCGA-BR-A4QI-01A	MTG1	chr10	135216277	+	PAOX	chr10	135194964	+
97055	BRCA	TCGA-BH-A0AV-01A	MTG1	chr10	135213123	+	PTK2	chr8	141762415	-
55669	STAD	TCGA-HU-A4H6	MTG1	chr10	135216277	+	ZNF350	chr19	52477784	-
94383	BRCA	TCGA-C8-A137	MTG1	chr10	135216277	+	ZNF511	chr10	135126291	+
94383	BRCA	TCGA-C8-A137-01A	MTG1	chr10	135216276	+	ZNF511	chr10	135126291	+
94383	BRCA	TCGA-C8-A137-01A	MTG1	chr10	135216277	+	ZNF511	chr10	135126292	+
101464	Non-Cancer	61N	ZNF124	chr1	247335149	-	MTG1	chr10	135232983	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
STAD	MTG1	0.0155765510280821	0.44
KIRP	MTG1	0.0447960155087526	1
THYM	MTG1	0.0491473724455778	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BRCA	MTG1	0.0440565865381447	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source