Home

Download

Statistics

Examples

Help

Contact

	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: METTL18 (NCBI Gene ID:92342)

Gene Summary

Gene Summary

Gene Information	Gene Name: METTL18
	Gene ID: 92342
	Gene Symbol	METTL18
	Gene ID	92342
	Gene Name	methyltransferase like 18
	Synonyms	AsTP2\|C1orf156\|HPM1
	Cytomap	1q24.2
	Type of Gene	protein-coding
	Description	histidine protein methyltransferase 1 homologarsenic-transactivated protein 2methyltransferase-like protein 18
	Modification date	20200313
	UniProtAcc	O95568

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
METTL18	>1119.25

Top

Translation Studies in PubMed

We searched PubMed using 'METTL18[title] AND translation [title] AND human.'

Gene	Title	PMID
METTL18	.	.

Top

Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

Top

Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type

Translation factor

adj.pval

Top

Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

Top

Associated Genes

Strongly correlated genes belong to cellular important gene groups with METTL18 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type

Gene group

Translation factor

Correlated gene

Coefficient

Pvalue

Top

Protein structure

Protein 3D structure
Visit iCn3D.

Top

Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	METTL18	RPL3	2.43523389101044	0.00016188295558095
STAD	METTL18	FAM86A	-1.89304681922427	0.000772962812334299
LUAD	METTL18	FAM173A	-2.66464647563882	0.00108589735114047
THCA	METTL18	FAM86A	-4.31040752436988	0.00312636019725738
KICH	METTL18	METTL10	-3.59880317233434	0.00672554969787598
KIRC	METTL18	FAM173A	1.03106917176545	0.0134377941040235
KIRP	METTL18	FAM173A	1.3137951609019	0.0294188209809363
UCEC	METTL18	FAM173A	-2.29615782891665	0.03125
ESCA	METTL18	RPL3	1.12882976357497	0.0322265625
LUSC	METTL18	METTL10	-1.54955144660658	0.0361736731847029
BRCA	METTL18	FAM173A	-2.28613438835398	1.19467565970998e-17
KIRC	METTL18	METTL10	-1.89180111741838	2.0768034584035e-05
THCA	METTL18	METTL10	-1.5205378319783	2.46790521879123e-10
KICH	METTL18	FAM173A	1.90301125900645	2.66432762145996e-05
HNSC	METTL18	METTL10	1.98185850393386	3.84812503853028e-05
LUSC	METTL18	FAM86A	-3.6886129577458	5.84081463924049e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with METTL18

PHYHIP, YAE1D1, RGS2, B3GALT4, HSP90AA1, HSPA4, GRWD1, RPL3, ANXA6, CCT2, CCT3, CCT4, CCT6A, CCT6B, CCT7, CCT8, EIF3I, EIF3K, H1FX, HSPA5, HSPA7, IARS, IPO7, KDM1A, HNRNPCL3, METTL1, MRPL49, POLR2H, PPIH, PRPF4, RARS, RUVBL1, RUVBL2, SNRPA1, SNRPD2, SNRPF, SRP14, SRP68, SRP72, SRP9, TCP1, TROVE2, TUBGCP2, LAMB4, PRICKLE3, SSX2, RIOK1, ESR1, DDX39A, TMEM45B, S100B, CCL3, FNDC8, TTC39A, FCGRT, PTGES2, TAGAP, PHKA2, SMAD4, IMPA1, MND1,

Top

Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
METTL18	chr1	169762180	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
METTL18	ACC	chr1	169762072	169762072	T	C	Silent	p.P255P	4
METTL18	LUAD	chr1	169762232	169762232	C	G	Missense_Mutation	p.G202A	4
METTL18	LUAD	chr1	169761944	169761944	T	C	Missense_Mutation	p.N298S	4
METTL18	LUAD	chr1	169762027	169762027	C	A	Missense_Mutation	p.W270C	3
METTL18	ESCA	chr1	169762095	169762095	C	A	Missense_Mutation	p.D248Y	3
METTL18	ESCA	chr1	169762250	169762250	C	A	Missense_Mutation	p.C196F	3
METTL18	COAD	chr1	169762038	169762038	A	-	Frame_Shift_Del	p.S267fs	2
METTL18	KIRC	chr1	169762230	169762230	T	G	Missense_Mutation	p.I203L	2
METTL18	UCEC	chr1	169761782	169761782	A	C	Missense_Mutation	p.L352R	2
METTL18	LIHC	chr1	169762807	169762807	T	G	Missense_Mutation		2
METTL18	UCEC	chr1	169761885	169761885	G	A	Missense_Mutation	p.R318C	2
METTL18	LIHC	chr1	169762228	169762228	T	G	Silent		2
METTL18	ESCA	chr1	169762095	169762095	C	A	Missense_Mutation		2
METTL18	UCEC	chr1	169762116	169762116	C	A	Nonsense_Mutation	p.E241*	2
METTL18	SKCM	chr1	169761910	169761910	G	A	Silent	p.F309F	2
METTL18	UCEC	chr1	169762181	169762181	T	C	Missense_Mutation	p.N219S	2
METTL18	SKCM	chr1	169762117	169762117	T	C	Silent	p.E240E	2
METTL18	UCEC	chr1	169762201	169762201	T	G	Missense_Mutation	p.E212D	2
METTL18	SKCM	chr1	169762312	169762312	G	A	Silent	p.L175L	2
METTL18	UCEC	chr1	169762632	169762632	C	T	Missense_Mutation	p.A69T	2
METTL18	CESC	chr1	169761916	169761916	C	G	Missense_Mutation		2
METTL18	LIHC	chr1	169762267	169762267	T	-	Frame_Shift_Del	p.K190fs	1
METTL18	CESC	chr1	169761916	169761916	C	G	Missense_Mutation	p.Q307H	1
METTL18	STAD	chr1	169762587	169762587	T	G	Missense_Mutation	p.S84R	1
METTL18	HNSC	chr1	169762501	169762501	C	T	Missense_Mutation	p.M112I	1
METTL18	BLCA	chr1	169761959	169761959	G	A	Missense_Mutation		1
METTL18	COAD	chr1	169761901	169761901	C	G	Silent	p.L312L	1
METTL18	THYM	chr1	169762830	169762830	A	G	Missense_Mutation		1
METTL18	HNSC	chr1	169761757	169761757	C	T	Silent	p.K360K	1
METTL18	BLCA	chr1	169762212	169762212	C	T	Missense_Mutation		1
METTL18	THYM	chr1	169762830	169762830	A	G	Missense_Mutation	p.F3L	1
METTL18	BLCA	chr1	169762167	169762167	C	G	Missense_Mutation		1
METTL18	LUAD	chr1	169762216	169762216	C	A	Missense_Mutation	p.K207N	1
METTL18	COAD	chr1	169762560	169762560	T	G	Missense_Mutation	p.K93Q	1
METTL18	THYM	chr1	169762207	169762207	G	T	Silent	p.S210S	1
METTL18	LGG	chr1	169762769	169762769	C	T	Missense_Mutation	p.G23E	1
METTL18	BLCA	chr1	169761939	169761939	C	T	Missense_Mutation		1
METTL18	BLCA	chr1	169761959	169761959	G	A	Missense_Mutation	p.S293L	1
METTL18	LUAD	chr1	169762469	169762469	C	A	Missense_Mutation	p.G123V	1
METTL18	BLCA	chr1	169762212	169762212	C	T	Missense_Mutation	p.G209R	1
METTL18	READ	chr1	169761966	169761966	G	T	Missense_Mutation	p.L291I	1
METTL18	LIHC	chr1	169761971	169761971	A	C	Missense_Mutation	p.L289R	1
METTL18	BLCA	chr1	169762167	169762167	C	G	Missense_Mutation	p.D224H	1
METTL18	ESCA	chr1	169761837	169761837	C	T	Missense_Mutation	p.V334I	1
METTL18	LIHC	chr1	169762228	169762228	T	G	Silent	p.I203I	1
METTL18	BLCA	chr1	169761964	169761964	G	A	Silent	p.L291L	1
METTL18	ESCA	chr1	169762414	169762414	G	T	Missense_Mutation	p.F141L	1
METTL18	LIHC	chr1	169762137	169762137	T	A	Missense_Mutation	p.N234Y	1
METTL18	BLCA	chr1	169761939	169761939	C	T	Missense_Mutation	p.D300N	1
METTL18	HNSC	chr1	169761757	169761757	C	T	Silent		1
METTL18	LIHC	chr1	169761806	169761807	-	T	Frame_Shift_Ins	p.R344fs	1
METTL18	SKCM	chr1	169762604	169762604	G	A	Missense_Mutation	p.P78L	1
METTL18	HNSC	chr1	169762501	169762501	C	T	Missense_Mutation		1

Copy number variation (CNV) of METTL18
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across METTL18
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
59746	N/A	EI787248	C1orf112	chr1	169761111	+	METTL18	chr1	169761113	+
59746	N/A	FN164452	C1orf112	chr1	169764343	-	METTL18	chr1	169763857	-
59763	SARC	TCGA-DX-A8BJ-01A	NOTCH2NL	chr1	145209436	+	METTL18	chr1	169763038	-

Top

Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

Top

Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

Top

Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

Top

Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source