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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: PIWIL1 (NCBI Gene ID:9271)

Gene Summary

Gene Summary

Gene Information	Gene Name: PIWIL1
	Gene ID: 9271
	Gene Symbol	PIWIL1
	Gene ID	9271
	Gene Name	piwi like RNA-mediated gene silencing 1
	Synonyms	CT80.1\|HIWI\|MIWI\|PIWI
	Cytomap	12q24.33
	Type of Gene	protein-coding
	Description	piwi-like protein 1piwi homolog
	Modification date	20200313
	UniProtAcc	Q96J94

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
PIWIL1	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'PIWIL1[title] AND translation [title] AND human.'

Gene	Title	PMID
PIWIL1	Domain-functional analyses of PIWIL1 and PABPC1 indicate their synergistic roles in protein translation via 3'-UTRs of meiotic mRNAs	29701755

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
THCA	PIWIL1	1.03261884319603	1.02220761620756e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
BLCA	PIWIL1	2	3	0.0259922652439781	0.499743183408296	0.667721929231463	-0.115085896622429	0.0123229567451183

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LGG	PIWIL1	0.022649872	0.009092111
KIRC	PIWIL1	-0.008537166	0.01782672

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with PIWIL1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
GBM	IUPHAR	PIWIL1	TAS2R41	0.813230813	8.02E-42
TGCT	CGC	PIWIL1	ELL	0.803926751	1.40E-36
TGCT	TF	PIWIL1	DMRT1	0.820034582	3.70E-39

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LIHC	PIWIL1	TDRKH	-2.35054040805301	0.000154274946618889
LIHC	PIWIL1	HSP90AA1	-1.87137739671902	0.0003817245773207
STAD	PIWIL1	TDRKH	-1.54610939736591	0.000772962812334299
PRAD	PIWIL1	MAEL	-2.3661636167606	0.000817525595737914
LUAD	PIWIL1	MAEL	-6.19185333647027	0.0016989769898434
HNSC	PIWIL1	TDRD1	-2.22172147165928	0.00186235073124408
BLCA	PIWIL1	MOV10L1	-2.2459025740491	0.0033416748046875
COAD	PIWIL1	MOV10L1	-1.2507305928268	0.00793844461441041
PRAD	PIWIL1	DICER1	1.54768558737379	0.0130781232419534
ESCA	PIWIL1	HSP90AA1	-2.95407832928575	0.0322265625
CHOL	PIWIL1	TDRKH	-3.94276179244914	0.0390625
STAD	PIWIL1	SND1	-1.35090264760896	0.0394268441013992
KICH	PIWIL1	TDRKH	1.37293937269262	1.0073184967041e-05
PRAD	PIWIL1	SND1	1.57586643979049	1.04230482302659e-08
LUSC	PIWIL1	STK31	1.32094735871635	1.07831278943457e-05
BRCA	PIWIL1	HSP90AA1	2.1978220577015	1.13731762084626e-08
PRAD	PIWIL1	TDRD1	2.58804684959852	1.77484038698563e-08
KIRP	PIWIL1	MOV10L1	2.29966204672133	2.0815059542656e-07
KICH	PIWIL1	SND1	-1.95895069042788	2.21133232116699e-05
LUAD	PIWIL1	STK31	1.53894578103664	2.41538977781656e-07
BRCA	PIWIL1	SND1	-2.76124672825104	2.63169890486136e-06
BRCA	PIWIL1	MAEL	-1.18581225781999	2.88434406714333e-05
STAD	PIWIL1	HSP90AA1	-1.65705125430285	3.51201742887497e-06
KIRC	PIWIL1	TDRKH	1.35420573562768	3.87430708887757e-09
COAD	PIWIL1	TDRKH	-1.761968138371	6.03199005126954e-05
THCA	PIWIL1	TDRD6	-1.70796617413818	7.22868172738035e-09

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with PIWIL1

TP53, TP63, TP73, DICER1, STMN1, TUBA1B, TUBB3, RNF8, TRIM54, TDRKH, BAG2, PDE6B,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
PIWIL1	READ	chr12	130833930	130833930	A	C	Missense_Mutation	p.K294T	5
PIWIL1	SKCM	chr12	130832683	130832683	G	A	Missense_Mutation	p.R230Q	5
PIWIL1	BRCA	chr12	130827177	130827177	G	A	Missense_Mutation	p.R14H	4
PIWIL1	BRCA	chr12	130833872	130833872	C	T	Nonsense_Mutation	p.R275*	4
PIWIL1	DLBC	chr12	130847589	130847589	G	A	Missense_Mutation	p.V699M	4
PIWIL1	BLCA	chr12	130846097	130846097	C	T	Missense_Mutation	p.R641W	4
PIWIL1	BRCA	chr12	130856048	130856048	C	G	Missense_Mutation	p.P831A	4
PIWIL1	LUAD	chr12	130839524	130839524	G	T	Silent	p.V421V	4
PIWIL1	BRCA	chr12	130827144	130827144	G	A	Missense_Mutation	p.G3E	4
PIWIL1	ESCA	chr12	130831046	130831046	C	A	Missense_Mutation	p.L150I	3
PIWIL1	GBM	chr12	130841563	130841563	G	A	Missense_Mutation	p.R502Q	3
PIWIL1	SKCM	chr12	130831058	130831058	G	A	Missense_Mutation	p.E154K	3
PIWIL1	PAAD	chr12	130827607	130827607	C	T	Missense_Mutation	p.R51W	3
PIWIL1	LUAD	chr12	130845802	130845802	C	A	Silent	p.T581T	3
PIWIL1	BRCA	chr12	130833916	130833916	G	A	Silent	p.Q289	3
PIWIL1	ESCA	chr12	130833811	130833811	T	C	Silent		3
PIWIL1	UCEC	chr12	130842054	130842054	T	C	Missense_Mutation	p.Y541H	3
PIWIL1	SKCM	chr12	130855736	130855736	C	T	Silent	p.I779I	3
PIWIL1	BRCA	chr12	130833950	130833950	A	G	Missense_Mutation	p.K301E	3
PIWIL1	SKCM	chr12	130831552	130831552	G	A	Missense_Mutation	p.E200K	3
PIWIL1	ACC	chr12	130830339	130830339	G	A	Missense_Mutation	p.E78K	3
PIWIL1	BRCA	chr12	130834441	130834441	G	A	Missense_Mutation	p.D325N	3
PIWIL1	HNSC	chr12	130840124	130840124	G	A	Missense_Mutation	p.R439Q	3
PIWIL1	SKCM	chr12	130841476	130841476	C	T	Missense_Mutation	p.P473L	3
PIWIL1	BRCA	chr12	130839517	130839517	G	A	Missense_Mutation	p.R419H	3
PIWIL1	SKCM	chr12	130845791	130845791	G	A	Missense_Mutation	p.D578N	3
PIWIL1	BRCA	chr12	130847321	130847321	C	T	Missense_Mutation	p.R661C	3
PIWIL1	ESCA	chr12	130833852	130833852	A	G	Missense_Mutation	p.D268G	3
PIWIL1	SKCM	chr12	130846099	130846099	G	A	Silent	p.R641R	3
PIWIL1	ESCA	chr12	130833811	130833811	T	C	Silent	p.T254T	3
PIWIL1	SKCM	chr12	130855747	130855747	C	T	Missense_Mutation	p.A783V	3
PIWIL1	COAD	chr12	130830316	130830316	G	A	Missense_Mutation	p.G70E	3
PIWIL1	BRCA	chr12	130831527	130831527	G	A	Silent	p.V191	3
PIWIL1	ESCA	chr12	130845767	130845767	G	A	Missense_Mutation	p.A570T	3
PIWIL1	UCS	chr12	130847640	130847640	G	A	Missense_Mutation	p.E716K	3
PIWIL1	LIHC	chr12	130827612	130827612	G	C	Missense_Mutation		3
PIWIL1	SARC	chr12	130846070	130846070	G	A	Missense_Mutation	p.D632N	3
PIWIL1	LUAD	chr12	130833803	130833803	T	A	Missense_Mutation	p.F252I	3
PIWIL1	LUAD	chr12	130841526	130841526	G	T	Missense_Mutation	p.V490F	2
PIWIL1	SARC	chr12	130839192	130839192	G	T	Missense_Mutation		2
PIWIL1	SKCM	chr12	130834508	130834508	G	A	Missense_Mutation	p.R347K	2
PIWIL1	BLCA	chr12	130847598	130847598	G	A	Missense_Mutation		2
PIWIL1	CESC	chr12	130831584	130831584	G	T	Missense_Mutation		2
PIWIL1	SARC	chr12	130851778	130851778	G	A	Missense_Mutation	p.D766N	2
PIWIL1	UCEC	chr12	130840102	130840102	G	A	Missense_Mutation	p.D432N	2
PIWIL1	LUAD	chr12	130841624	130841624	G	C	Missense_Mutation	p.M522I	2
PIWIL1	PAAD	chr12	130834500	130834500	A	C	Missense_Mutation		2
PIWIL1	PRAD	chr12	130841508	130841508	G	T	Missense_Mutation	p.G484C	2
PIWIL1	SKCM	chr12	130841494	130841494	C	T	Missense_Mutation	p.S479F	2
PIWIL1	COAD	chr12	130855727	130855728	-	T	Frame_Shift_Ins	p.D776fs	2
PIWIL1	LUAD	chr12	130847575	130847575	C	A	Missense_Mutation	p.P694H	2
PIWIL1	SARC	chr12	130846070	130846070	G	A	Missense_Mutation		2
PIWIL1	SKCM	chr12	130855797	130855797	A	C	Missense_Mutation	p.N800H	2
PIWIL1	CESC	chr12	130856118	130856118	T	C	Missense_Mutation	p.L854P	2
PIWIL1	SKCM	chr12	130846060	130846060	C	T	Silent	p.I628I	2
PIWIL1	BLCA	chr12	130833873	130833873	G	A	Missense_Mutation	p.R275Q	2
PIWIL1	UCEC	chr12	130840189	130840189	A	C	Missense_Mutation	p.K461Q	2
PIWIL1	LUAD	chr12	130831129	130831129	G	T	Splice_Site	p.K177_splice	2
PIWIL1	SKCM	chr12	130846112	130846112	G	A	Missense_Mutation	p.G646R	2
PIWIL1	COAD	chr12	130855802	130855802	C	T	Silent	p.S801S	2
PIWIL1	ESCA	chr12	130855864	130855864	G	T	Missense_Mutation	p.W822L	2
PIWIL1	HNSC	chr12	130851726	130851726	T	G	Missense_Mutation	p.F748L	2
PIWIL1	LIHC	chr12	130842075	130842075	A	G	Missense_Mutation	p.K548E	2
PIWIL1	LUAD	chr12	130842061	130842061	G	A	Missense_Mutation	p.R543K	2
PIWIL1	SARC	chr12	130830950	130830950	C	A	Missense_Mutation		2
PIWIL1	CESC	chr12	130827568	130827568	C	T	Nonsense_Mutation	p.Q38*	2
PIWIL1	SKCM	chr12	130856078	130856078	C	T	Missense_Mutation	p.L841F	2
PIWIL1	BLCA	chr12	130839176	130839176	C	G	Missense_Mutation	p.A380G	2
PIWIL1	UCEC	chr12	130841499	130841499	G	T	Nonsense_Mutation	p.E481*	2
PIWIL1	PAAD	chr12	130834500	130834500	A	C	Missense_Mutation	p.E344D	2
PIWIL1	SKCM	chr12	130845883	130845883	G	A	Missense_Mutation	p.M608I	2
PIWIL1	LUAD	chr12	130827556	130827556	C	T	Nonsense_Mutation	p.Q34*	2
PIWIL1	SARC	chr12	130833979	130833979	C	A	Silent		2
PIWIL1	BLCA	chr12	130840202	130840202	G	A	Missense_Mutation	p.G465D	2
PIWIL1	COAD	chr12	130839451	130839451	G	A	Missense_Mutation	p.R397H	2
PIWIL1	STAD	chr12	130856119	130856119	G	T	Silent	p.L854L	2
PIWIL1	UCEC	chr12	130842043	130842043	G	T	Missense_Mutation	p.R537I	2
PIWIL1	LIHC	chr12	130845801	130845801	C	-	Frame_Shift_Del	p.T581fs	2
PIWIL1	LUAD	chr12	130830955	130830955	C	A	Missense_Mutation	p.F119L	2
PIWIL1	ESCA	chr12	130833904	130833904	C	T	Silent		2
PIWIL1	HNSC	chr12	130831562	130831562	C	A	Missense_Mutation	p.P203H	2
PIWIL1	LIHC	chr12	130834407	130834407	C	T	Silent		2
PIWIL1	LIHC	chr12	130834407	130834407	C	T	Silent	p.N313N	2
PIWIL1	SARC	chr12	130834413	130834413	G	T	Missense_Mutation		2
PIWIL1	SKCM	chr12	130827617	130827617	G	A	Missense_Mutation	p.G54E	2
PIWIL1	BLCA	chr12	130847598	130847598	G	A	Missense_Mutation	p.D702N	2
PIWIL1	STAD	chr12	130845758	130845758	A	G	Missense_Mutation	p.K567E	2
PIWIL1	UCEC	chr12	130847361	130847361	G	A	Missense_Mutation	p.G674E	2
PIWIL1	ESCA	chr12	130833852	130833852	A	G	Missense_Mutation		2
PIWIL1	UCEC	chr12	130830411	130830411	G	A	Missense_Mutation	p.E102K	2
PIWIL1	LIHC	chr12	130830386	130830386	A	G	Silent		2
PIWIL1	SKCM	chr12	130842043	130842043	G	A	Missense_Mutation	p.R537K	2
PIWIL1	STAD	chr12	130842068	130842068	A	G	Silent	p.L545L	2
PIWIL1	UCEC	chr12	130847536	130847536	C	T	Missense_Mutation	p.A681V	2
PIWIL1	ESCA	chr12	130845767	130845767	G	A	Missense_Mutation		2
PIWIL1	HNSC	chr12	130827590	130827590	A	T	Missense_Mutation	p.E45V	2
PIWIL1	UCEC	chr12	130831129	130831129	G	T	Missense_Mutation	p.K177N	2
PIWIL1	LIHC	chr12	130827612	130827612	G	C	Missense_Mutation	p.Q52H	2
PIWIL1	SKCM	chr12	130856036	130856036	C	T	Missense_Mutation	p.R827C	2
PIWIL1	ESCA	chr12	130833811	130833811	T	C	Silent	p.T254	2
PIWIL1	STAD	chr12	130846109	130846109	G	A	Missense_Mutation	p.A645T	2
PIWIL1	UCEC	chr12	130855780	130855780	A	C	Missense_Mutation	p.Y794S	2
PIWIL1	LUAD	chr12	130839197	130839197	G	T	Missense_Mutation	p.C387F	2
PIWIL1	PRAD	chr12	130840152	130840152	C	A	Missense_Mutation	p.N448K	2
PIWIL1	UCEC	chr12	130831536	130831536	G	A	Silent	p.T194	2
PIWIL1	LIHC	chr12	130842075	130842075	A	G	Missense_Mutation		2
PIWIL1	LIHC	chr12	130830386	130830386	A	G	Silent	p.T93T	2
PIWIL1	SARC	chr12	130851778	130851778	G	A	Missense_Mutation		2
PIWIL1	STAD	chr12	130855769	130855769	T	G	Silent	p.S790S	2
PIWIL1	UCEC	chr12	130855795	130855795	A	G	Missense_Mutation	p.D799G	2
PIWIL1	PRAD	chr12	130830351	130830351	C	T	Missense_Mutation	p.R82C	2
PIWIL1	UCEC	chr12	130833783	130833783	G	T	Splice_Site	e7-1	2
PIWIL1	SARC	chr12	130834413	130834413	G	T	Missense_Mutation	p.K315N	2
PIWIL1	SKCM	chr12	130840172	130840172	G	A	Missense_Mutation	p.R455K	2
PIWIL1	HNSC	chr12	130827639	130827639	G	A	Silent	p.K61K	2
PIWIL1	PRAD	chr12	130845793	130845793	T	G	Missense_Mutation	p.D578E	2
PIWIL1	CESC	chr12	130856118	130856118	T	C	Missense_Mutation		2
PIWIL1	ESCA	chr12	130833904	130833904	C	T	Silent	p.N285N	2
PIWIL1	BLCA	chr12	130834457	130834457	G	A	Missense_Mutation	p.S330N	2
PIWIL1	UCEC	chr12	130834455	130834455	G	T	Missense_Mutation	p.K329N	2
PIWIL1	LIHC	chr12	130833932	130833932	T	-	Frame_Shift_Del	p.F295fs	2
PIWIL1	SKCM	chr12	130830393	130830393	A	C	Missense_Mutation	p.N96H	2
PIWIL1	STAD	chr12	130856060	130856060	G	T	Missense_Mutation	p.A835S	2
PIWIL1	PRAD	chr12	130851735	130851735	G	C	Missense_Mutation	p.Q751H	2
PIWIL1	SKCM	chr12	130847658	130847658	G	A	Missense_Mutation	p.D722N	2
PIWIL1	ESCA	chr12	130847365	130847365	C	G	Silent	p.L675L	2
PIWIL1	BLCA	chr12	130830392	130830392	G	A	Silent	p.Q95Q	2
PIWIL1	UCEC	chr12	130834471	130834471	G	A	Missense_Mutation	p.A335T	2
PIWIL1	LIHC	chr12	130845773	130845773	A	-	Frame_Shift_Del	p.K573fs	2
PIWIL1	SKCM	chr12	130827153	130827153	G	A	Missense_Mutation	p.R6Q	2
PIWIL1	STAD	chr12	130834487	130834487	T	C	Missense_Mutation	p.V340A	2
PIWIL1	HNSC	chr12	130831541	130831541	C	A	Missense_Mutation	p.T196N	2
PIWIL1	THYM	chr12	130834477	130834477	G	T	Missense_Mutation	p.G337C	1
PIWIL1	KIRC	chr12	130847573	130847573	G	A	Missense_Mutation	p.M693I	1
PIWIL1	ESCA	chr12	130845822	130845822	C	T	Missense_Mutation	p.A588V	1
PIWIL1	SKCM	chr12	130842030	130842030	G	A	Missense_Mutation	p.E533K	1
PIWIL1	BLCA	chr12	130831078	130831078	T	A	Nonsense_Mutation	p.C160*	1
PIWIL1	COAD	chr12	130831096	130831096	G	A	Silent	p.T166T	1
PIWIL1	SKCM	chr12	130847362	130847362	G	A	Silent	p.G674G	1
PIWIL1	HNSC	chr12	130840124	130840124	G	A	Missense_Mutation		1
PIWIL1	LIHC	chr12	130834496	130834496	T	C	Missense_Mutation		1
PIWIL1	LIHC	chr12	130846094	130846094	G	-	Frame_Shift_Del	p.G640fs	1
PIWIL1	LUSC	chr12	130827214	130827214	C	T	Silent	p.A26_splice	1
PIWIL1	STAD	chr12	130841471	130841471	C	A	Nonsense_Mutation	p.Y471*	1
PIWIL1	HNSC	chr12	130847537	130847537	G	A	Splice_Site	p.A681_splice	1
PIWIL1	THYM	chr12	130827627	130827627	A	G	Silent	p.G57G	1
PIWIL1	LGG	chr12	130846069	130846069	C	T	Silent	p.I631I	1
PIWIL1	BLCA	chr12	130830396	130830396	C	T	Silent		1
PIWIL1	SKCM	chr12	130846137	130846137	G	A	Missense_Mutation	p.G654E	1
PIWIL1	COAD	chr12	130833914	130833914	C	T	Nonsense_Mutation	p.Q289X	1
PIWIL1	HNSC	chr12	130831562	130831562	C	A	Missense_Mutation		1
PIWIL1	LIHC	chr12	130856074	130856074	T	-	Frame_Shift_Del	p.A839fs	1
PIWIL1	LUSC	chr12	130840128	130840128	C	A	Missense_Mutation	p.D440E	1
PIWIL1	STAD	chr12	130855728	130855729	-	T	Frame_Shift_Ins	p.D776fs	1
PIWIL1	GBM	chr12	130847606	130847606	A	G	Silent	p.V704V	1
PIWIL1	UCEC	chr12	130847536	130847536	C	T	Missense_Mutation	p.A681_splice	1
PIWIL1	LGG	chr12	130855859	130855859	C	T	Silent	p.Y820Y	1
PIWIL1	SKCM	chr12	130855925	130855925	G	A	Splice_Site	.	1
PIWIL1	BLCA	chr12	130846097	130846097	C	T	Missense_Mutation		1
PIWIL1	SKCM	chr12	130830989	130830989	C	T	Nonsense_Mutation	p.Q131*	1
PIWIL1	COAD	chr12	130839165	130839165	G	A	Silent	p.L376L	1
PIWIL1	STAD	chr12	130856119	130856119	G	T	Silent		1
PIWIL1	HNSC	chr12	130827590	130827590	A	T	Missense_Mutation		1
PIWIL1	LIHC	chr12	130839146	130839146	G	-	Frame_Shift_Del	p.R370fs	1
PIWIL1	LUSC	chr12	130845880	130845880	G	T	Missense_Mutation	p.Q607H	1
PIWIL1	READ	chr12	130833953	130833953	G	T	Nonsense_Mutation	p.E302X	1
PIWIL1	THCA	chr12	130846145	130846145	C	A	Missense_Mutation		1
PIWIL1	HNSC	chr12	130833938	130833938	G	C	Missense_Mutation	p.E297Q	1
PIWIL1	GBM	chr12	130833883	130833883	T	A	Silent	p.T278T	1
PIWIL1	LGG	chr12	130855859	130855859	C	T	Silent		1
PIWIL1	LIHC	chr12	130832690	130832690	T	C	Silent	p.Y232Y	1
PIWIL1	BLCA	chr12	130840111	130840111	C	A	Missense_Mutation		1
PIWIL1	CESC	chr12	130842072	130842072	C	T	Nonsense_Mutation		1
PIWIL1	SKCM	chr12	130830989	130830989	C	T	Nonsense_Mutation	p.Q131X	1
PIWIL1	SKCM	chr12	130840207	130840207	A	T	Nonsense_Mutation	p.K467*	1
PIWIL1	COAD	chr12	130856060	130856060	G	A	Missense_Mutation	p.A835T	1
PIWIL1	HNSC	chr12	130831541	130831541	C	A	Missense_Mutation		1
PIWIL1	LUSC	chr12	130831075	130831075	G	A	Silent	p.K159K	1
PIWIL1	PRAD	chr12	130839528	130839528	C	T	Nonsense_Mutation	p.R423X	1
PIWIL1	READ	chr12	130841527	130841527	T	C	Missense_Mutation	p.V490A	1
PIWIL1	SKCM	chr12	130830321	130830321	C	T	Nonsense_Mutation	p.Q72X	1
PIWIL1	THYM	chr12	130846108	130846108	C	T	Silent		1
PIWIL1	GBM	chr12	130830969	130830969	G	A	Missense_Mutation	p.R124H	1
PIWIL1	UCEC	chr12	130851697	130851699	GTG	-	In_Frame_Del	p.V740del	1
PIWIL1	LUAD	chr12	130841621	130841621	C	A	Silent	p.A521A	1
PIWIL1	SKCM	chr12	130831604	130831604	G	A	Missense_Mutation	p.R217K	1
PIWIL1	BLCA	chr12	130832712	130832712	G	A	Missense_Mutation		1
PIWIL1	CESC	chr12	130827568	130827568	C	T	Nonsense_Mutation		1
PIWIL1	SKCM	chr12	130842051	130842051	G	A	Missense_Mutation	p.A540T	1
PIWIL1	COAD	chr12	130842058	130842058	T	C	Missense_Mutation	p.L542S	1
PIWIL1	HNSC	chr12	130847589	130847589	G	A	Missense_Mutation		1
PIWIL1	LIHC	chr12	130847652	130847652	T	-	Frame_Shift_Del	p.F720fs	1
PIWIL1	LUSC	chr12	130847603	130847603	C	T	Silent	p.G703G	1
PIWIL1	LUAD	chr12	130831590	130831590	T	A	Nonsense_Mutation	p.Y212*	1
PIWIL1	PRAD	chr12	130827193	130827193	G	A	Silent	p.A19A	1
PIWIL1	READ	chr12	130851689	130851689	C	T	Missense_Mutation	p.T736M	1
PIWIL1	THYM	chr12	130834477	130834477	G	T	Missense_Mutation		1
PIWIL1	BLCA	chr12	130847597	130847597	C	T	Silent		1
PIWIL1	CESC	chr12	130842072	130842072	C	T	Nonsense_Mutation	p.Q547*	1
PIWIL1	GBM	chr12	130847606	130847606	A	G	Silent		1
PIWIL1	LIHC	chr12	130834496	130834496	T	C	Missense_Mutation	p.L343S	1
PIWIL1	LUAD	chr12	130827548	130827548	G	T	Missense_Mutation	p.G31V	1
PIWIL1	SARC	chr12	130840201	130840201	G	T	Missense_Mutation		1
PIWIL1	SKCM	chr12	130847340	130847340	G	A	Missense_Mutation	p.R667K	1
PIWIL1	SKCM	chr12	130840195	130840195	C	T	Missense_Mutation	p.H463Y	1
PIWIL1	BLCA	chr12	130830396	130830396	C	T	Silent	p.L97L	1
PIWIL1	COAD	chr12	130842087	130842087	G	T	Missense_Mutation	p.D552Y	1
PIWIL1	DLBC	chr12	130855827	130855827	C	T	Missense_Mutation	p.R810C	1
PIWIL1	HNSC	chr12	130827178	130827178	C	T	Silent		1
PIWIL1	LIHC	chr12	130847666	130847666	A	-	Frame_Shift_Del	p.L724fs	1
PIWIL1	LUSC	chr12	130832721	130832721	A	T	Missense_Mutation	p.S243C	1
PIWIL1	LUAD	chr12	130845875	130845875	C	T	Silent	p.L606L	1
PIWIL1	PRAD	chr12	130839528	130839528	C	T	Nonsense_Mutation	p.R423*	1
PIWIL1	READ	chr12	130833931	130833931	A	C	Missense_Mutation	p.K294N	1
PIWIL1	BLCA	chr12	130839546	130839546	C	T	Missense_Mutation		1
PIWIL1	THYM	chr12	130842077	130842077	G	T	Missense_Mutation	p.K548N	1
PIWIL1	BLCA	chr12	130856036	130856036	C	T	Missense_Mutation		1
PIWIL1	CHOL	chr12	130832683	130832683	G	T	Missense_Mutation		1
PIWIL1	GBM	chr12	130833883	130833883	T	A	Silent		1
PIWIL1	LIHC	chr12	130834462	130834462	T	C	Missense_Mutation		1
PIWIL1	LUAD	chr12	130833896	130833896	A	T	Missense_Mutation	p.M283L	1
PIWIL1	SARC	chr12	130831551	130831551	T	C	Silent		1
PIWIL1	SKCM	chr12	130830321	130830321	C	T	Nonsense_Mutation	p.Q72*	1
PIWIL1	SKCM	chr12	130830331	130830331	C	T	Missense_Mutation	p.S75L	1
PIWIL1	COAD	chr12	130845841	130845841	G	A	Silent	p.Q594Q	1
PIWIL1	HNSC	chr12	130833938	130833938	G	C	Missense_Mutation		1
PIWIL1	LIHC	chr12	130851724	130851724	T	-	Frame_Shift_Del	p.F749fs	1
PIWIL1	LUSC	chr12	130840130	130840130	G	A	Nonsense_Mutation	p.W441*	1
PIWIL1	READ	chr12	130839474	130839474	G	T	Missense_Mutation	p.D405Y	1
PIWIL1	BLCA	chr12	130834457	130834457	G	A	Missense_Mutation		1
PIWIL1	ESCA	chr12	130847365	130847365	C	G	Silent		1
PIWIL1	THYM	chr12	130855878	130855878	T	C	Missense_Mutation	p.S827P	1
PIWIL1	HNSC	chr12	130847537	130847537	G	A	Silent	p.A681A	1
PIWIL1	BLCA	chr12	130839546	130839546	C	T	Missense_Mutation	p.H429Y	1
PIWIL1	CHOL	chr12	130832683	130832683	G	T	Missense_Mutation	p.R230L	1
PIWIL1	GBM	chr12	130830969	130830969	G	A	Missense_Mutation		1
PIWIL1	LUSC	chr12	130839091	130839091	C	A	Missense_Mutation	p.Q352K	1
PIWIL1	SKCM	chr12	130855775	130855775	A	C	Silent	p.T792T	1
PIWIL1	SKCM	chr12	130831091	130831091	G	T	Nonsense_Mutation	p.G165X	1
PIWIL1	SKCM	chr12	130841620	130841620	C	T	Missense_Mutation	p.A521V	1
PIWIL1	BLCA	chr12	130851733	130851733	C	T	Nonsense_Mutation	p.Q751*	1
PIWIL1	COAD	chr12	130845926	130845926	G	A	Splice_Site	.	1
PIWIL1	HNSC	chr12	130841546	130841546	G	A	Nonsense_Mutation	p.W496*	1
PIWIL1	LUAD	chr12	130839155	130839155	G	T	Missense_Mutation	p.G373V	1
PIWIL1	OV	chr12	130847320	130847320	A	C	Silent	p.S660S	1
PIWIL1	LUAD	chr12	130847582	130847582	G	C	Silent	p.R696R	1
PIWIL1	SARC	chr12	130831088	130831088	G	T	Missense_Mutation		1
PIWIL1	BLCA	chr12	130830392	130830392	G	A	Silent		1
PIWIL1	THYM	chr12	130846108	130846108	C	T	Silent	p.I644I	1
PIWIL1	KIRC	chr12	130839159	130839159	G	T	Silent	p.G374G	1
PIWIL1	BLCA	chr12	130832682	130832682	C	T	Nonsense_Mutation	p.R230*	1
PIWIL1	COAD	chr12	130827215	130827215	G	A	Splice_Site	.	1
PIWIL1	GBM	chr12	130841563	130841563	G	A	Missense_Mutation		1
PIWIL1	LIHC	chr12	130832672	130832672	A	G	Silent		1
PIWIL1	LIHC	chr12	130847644	130847644	T	C	Missense_Mutation	p.V717A	1
PIWIL1	LUSC	chr12	130827641	130827641	C	A	Nonsense_Mutation	p.S62*	1
PIWIL1	SKCM	chr12	130855774	130855774	C	A	Missense_Mutation	p.T792K	1
PIWIL1	SKCM	chr12	130856048	130856048	C	T	Missense_Mutation	p.P831S	1
PIWIL1	BLCA	chr12	130847597	130847597	C	T	Silent	p.R701R	1
PIWIL1	COAD	chr12	130846146	130846146	G	A	Missense_Mutation	p.R657H	1
PIWIL1	ESCA	chr12	130833904	130833904	C	T	Silent	p.N285	1
PIWIL1	STAD	chr12	130841471	130841471	C	A	Nonsense_Mutation	p.Y471X	1
PIWIL1	UCS	chr12	130847640	130847640	G	A	Missense_Mutation		1
PIWIL1	LUAD	chr12	130831604	130831604	G	T	Missense_Mutation	p.R217M	1
PIWIL1	OV	chr12	130831585	130831585	T	A	Missense_Mutation	p.F211I	1
PIWIL1	LUAD	chr12	130841562	130841562	C	T	Nonsense_Mutation	p.R502*	1
PIWIL1	SARC	chr12	130840119	130840119	G	T	Missense_Mutation		1
PIWIL1	BLCA	chr12	130833873	130833873	G	A	Missense_Mutation		1
PIWIL1	THYM	chr12	130831605	130831605	G	T	Missense_Mutation	p.R217S	1
PIWIL1	KIRC	chr12	130845828	130845828	C	A	Missense_Mutation	p.T590N	1
PIWIL1	HNSC	chr12	130851726	130851726	T	G	Missense_Mutation		1
PIWIL1	LIHC	chr12	130830917	130830917	T	C	Missense_Mutation		1
PIWIL1	LUSC	chr12	130827577	130827577	C	A	Missense_Mutation	p.P41T	1
PIWIL1	SARC	chr12	130830950	130830950	C	A	Missense_Mutation	p.H118N	1
PIWIL1	SKCM	chr12	130833935	130833935	C	T	Nonsense_Mutation	p.Q296*	1
PIWIL1	COAD	chr12	130847612	130847612	C	T	Silent	p.D706D	1
PIWIL1	HNSC	chr12	130827178	130827178	C	T	Silent	p.R14R	1
PIWIL1	LUAD	chr12	130832712	130832712	G	T	Missense_Mutation	p.D240Y	1
PIWIL1	OV	chr12	129406076	129406076	C	G	Missense_Mutation	p.R439G	1
PIWIL1	SARC	chr12	130834421	130834421	G	T	Missense_Mutation		1
PIWIL1	BLCA	chr12	130839176	130839176	C	G	Missense_Mutation		1
PIWIL1	CESC	chr12	130839165	130839165	G	A	Silent		1
PIWIL1	THYM	chr12	130845896	130845896	G	T	Nonsense_Mutation	p.G613X	1
PIWIL1	KIRC	chr12	130847615	130847615	C	T	Silent	p.G707G	1
PIWIL1	COAD	chr12	130830355	130830355	G	A	Missense_Mutation	p.R83H	1
PIWIL1	HNSC	chr12	130847537	130847537	G	A	Silent		1
PIWIL1	LUSC	chr12	130841573	130841573	T	C	Silent	p.Y505Y	1
PIWIL1	SKCM	chr12	130831091	130831091	G	T	Nonsense_Mutation	p.G165*	1
PIWIL1	COAD	chr12	130847651	130847652	-	T	Frame_Shift_Ins	p.Q719fs	1
PIWIL1	ESCA	chr12	130847365	130847365	C	G	Silent	p.L675	1
PIWIL1	PAAD	chr12	130827607	130827607	C	T	Missense_Mutation		1

Copy number variation (CNV) of PIWIL1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across PIWIL1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
103203	N/A	AI147734	PIWIL1	chr12	130893959	+	RPS4Y1	chrY	2752404	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	PIWIL1	0.000241409779848489	0.0068
LUAD	PIWIL1	0.0285324174985497	0.77
READ	PIWIL1	0.0323715303909231	0.84

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	PIWIL1	0.0014510305149699	0.046
STAD	PIWIL1	0.000209564521799999	0.0069
THCA	PIWIL1	0.0104035894046191	0.3
LGG	PIWIL1	0.0126820985955319	0.36
PAAD	PIWIL1	0.0042075201207119	0.13
ESCA	PIWIL1	0.0253484195849634	0.68
BLCA	PIWIL1	0.0075745481626745	0.23

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
C0038580	Substance Dependence	1	CTD_human
C0740858	Substance abuse problem	1	CTD_human