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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: DPH7 (NCBI Gene ID:92715)

Gene Summary

Gene Summary

Gene Information	Gene Name: DPH7
	Gene ID: 92715
	Gene Symbol	DPH7
	Gene ID	92715
	Gene Name	diphthamide biosynthesis 7
	Synonyms	C9orf112\|RRT2\|WDR85
	Cytomap	9q34.3
	Type of Gene	protein-coding
	Description	diphthine methyltransferaseWD repeat-containing protein 85
	Modification date	20200313
	UniProtAcc	Q9BTV6

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006414	Translational elongation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
DPH7	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'DPH7[title] AND translation [title] AND human.'

Gene	Title	PMID
DPH7	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000277540	140458885	140459058	Frame-shift
ENST00000277540	140459344	140459410	In-frame
ENST00000277540	140468659	140468832	Frame-shift
ENST00000277540	140469203	140469295	Frame-shift
ENST00000277540	140471921	140472055	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000277540	140459344	140459410	1864	869	934	452	237	258

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9BTV6	237	258	1	452	Chain	ID=PRO_0000050906;Note=Diphthine methyltransferase
Q9BTV6	237	258	230	273	Repeat	Note=WD 4

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type

Translation factor

adj.pval

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with DPH7 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type

Gene group

Translation factor

Correlated gene

Coefficient

Pvalue

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	DPH7	B3GALT4	-1.43400453563912	0.000213860534131527
LUSC	DPH7	B3GALT4	-1.39572871514864	0.000251881966259792
HNSC	DPH7	EEF2	-1.90805330069302	0.000299885096865183
LUAD	DPH7	ELP2	-2.09247157171362	0.00034760699866943
KICH	DPH7	DNAJC24	1.38964695145852	0.000376403331756592
LUAD	DPH7	B3GALT4	-1.02715732971921	0.0005703312587627
LUSC	DPH7	DPH5	-1.6235156890085	0.000679097693381554
THCA	DPH7	EEF2	1.35574858496176	0.000711089919756285
HNSC	DPH7	DPH5	1.65799576563523	0.000797143226918707
BRCA	DPH7	DNAJC24	-1.14389652312681	0.000902838651961803
BLCA	DPH7	B3GALT4	-1.95779076092366	0.00141143798828125
COAD	DPH7	EEF2	1.67025113686866	0.00197160243988037
HNSC	DPH7	DPH2	1.63786614401166	0.00315447678462988
CHOL	DPH7	HRSP12	-2.34139144385446	0.00390625
HNSC	DPH7	B3GALT4	-1.31438139543752	0.0040605245990264
STAD	DPH7	EEF2	-1.87846190344448	0.00733334058895707
ESCA	DPH7	EEF2	-3.4598326417414	0.0185546875
CHOL	DPH7	ELP2	-3.27840418343916	0.02734375
BLCA	DPH7	HRSP12	-1.00941399684403	0.040130615234375
PRAD	DPH7	DPH5	1.05284539715115	0.0496995842628905
STAD	DPH7	HRSP12	-1.44964694777407	0.0497693861834705
THCA	DPH7	B3GALT4	1.25819211026078	1.14647631279e-06
PRAD	DPH7	B3GALT4	-1.46542062641954	1.26099370313262e-05
LIHC	DPH7	ELP2	-1.93985492408654	1.3390243553871e-05
BRCA	DPH7	DPH3	-2.55959741191714	1.53711242061404e-07
PRAD	DPH7	DPH1	1.04649113686082	2.13559901421379e-06
PRAD	DPH7	EEF2	1.63926479894191	2.70126293247147e-08
PRAD	DPH7	DPH2	-1.7499736242082	3.91792760836218e-09
BRCA	DPH7	DPH2	-2.32663867065443	6.11363360281251e-08
LUAD	DPH7	DPH5	-1.84948986969044	6.6826904409067e-05
KIRP	DPH7	HRSP12	-1.16272045758797	6.68526627123356e-05
LUAD	DPH7	DPH3	-3.59138499390076	7.41012444787115e-08
KICH	DPH7	DPH5	2.78540560574647	8.80360603332519e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with DPH7

CUL3, SHMT2, MOV10, NXF1, PML, XRCC1, ZBTB33, Mis12, Chmp4b, Dennd6a, RALGAPA2, ZNF446, RALGAPB, NPB, INCA1, CCT2, TEKT2,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
DPH7	chr9	140458903	T	C	single_nucleotide_variant	Uncertain_significance	Malignant_tumor_of_prostate	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
DPH7	SKCM	chr9	140468793	140468793	G	A	Silent	p.S169S	2
DPH7	KIRC	chr9	140469236	140469236	C	T	Silent	p.L145L	2
DPH7	BLCA	chr9	140472024	140472024	C	A	Missense_Mutation		1
DPH7	SKCM	chr9	140450068	140450068	G	A	Missense_Mutation	p.H328Y	1
DPH7	ESCA	chr9	140473264	140473264	G	C	Missense_Mutation		1
DPH7	LIHC	chr9	140468739	140468739	T	-	Frame_Shift_Del	p.K187fs	1
DPH7	BLCA	chr9	140469295	140469295	T	C	Missense_Mutation		1
DPH7	SKCM	chr9	140470610	140470610	G	A	Silent	p.I99I	1
DPH7	ESCA	chr9	140473262	140473262	T	C	Missense_Mutation		1
DPH7	LIHC	chr9	140459563	140459563	G	-	Frame_Shift_Del	p.P228fs	1
DPH7	BLCA	chr9	140458893	140458893	C	G	Missense_Mutation		1
DPH7	SKCM	chr9	140450052	140450052	G	A	Missense_Mutation	p.S333L	1
DPH7	HNSC	chr9	140469251	140469251	C	T	Silent		1
DPH7	LUAD	chr9	140458994	140458994	C	A	Missense_Mutation	p.V281L	1
DPH7	BLCA	chr9	140449838	140449838	C	T	Silent		1
DPH7	SKCM	chr9	140469211	140469211	T	G	Missense_Mutation	p.T154P	1
DPH7	HNSC	chr9	140473185	140473185	G	A	Silent	p.T15T	1
DPH7	LUAD	chr9	140449977	140449977	C	A	Missense_Mutation	p.S358I	1
DPH7	BLCA	chr9	140472024	140472024	C	A	Missense_Mutation	p.R62L	1
DPH7	SKCM	chr9	140469207	140469207	C	T	Missense_Mutation	p.G155E	1
DPH7	HNSC	chr9	140469251	140469251	C	T	Silent	p.E140E	1
DPH7	LUAD	chr9	140459346	140459346	T	-	Splice_Site	p.S259_splice	1
DPH7	BLCA	chr9	140472031	140472031	G	A	Nonsense_Mutation	p.Q60*	1
DPH7	PRAD	chr9	140459546	140459546	G	C	Missense_Mutation	p.T234S	1
DPH7	BLCA	chr9	140469295	140469295	T	C	Splice_Site	p.K126E	1
DPH7	SKCM	chr9	140458908	140458908	G	A	Silent	p.I309I	1
DPH7	KIRC	chr9	140449823	140449823	C	-	Frame_Shift_Del	p.W409fs	1
DPH7	PRAD	chr9	140468754	140468754	C	G	Missense_Mutation	p.R182S	1
DPH7	BLCA	chr9	140458893	140458893	C	G	Missense_Mutation	p.K314N	1
DPH7	SKCM	chr9	140450030	140450030	C	T	Nonsense_Mutation	p.W340*	1
DPH7	LGG	chr9	140449968	140449968	C	T	Missense_Mutation	p.G361E	1
DPH7	SARC	chr9	140473152	140473152	G	T	Silent		1
DPH7	BLCA	chr9	140449838	140449838	C	T	Silent	p.R404R	1
DPH7	LGG	chr9	140449846	140449846	C	T	Missense_Mutation	p.G402S	1
DPH7	SARC	chr9	140468677	140468677	G	T	Missense_Mutation		1
DPH7	ESCA	chr9	140473262	140473262	T	C	RNA	NULL	1
DPH7	LGG	chr9	140472007	140472007	G	T	Missense_Mutation	p.L68M	1
DPH7	SKCM	chr9	140459359	140459359	G	A	Silent	p.I254I	1
DPH7	ESCA	chr9	140473264	140473264	G	C	RNA	NULL	1
DPH7	LGG	chr9	140459020	140459020	A	G	Missense_Mutation	p.M272T	1

Copy number variation (CNV) of DPH7
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across DPH7
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
102613	N/A	AX184642	DPH7	chr9	140459564	-	KAZN	chr1	15385152	+
103207	N/A	CB049418	DPH7	chr9	140449356	-	MTUS2	chr13	29777696	+
99127	BRCA	TCGA-E2-A159-01A	DPH7	chr9	140468660	-	PPP2R4	chr9	131885331	+
99127	BRCA	TCGA-E2-A159-01A	DPH7	chr9	140470532	-	PPP2R4	chr9	131885331	+
70157	Non-Cancer	TCGA-FL-A1YG-11A	DPH7	chr9	140473090	-	PTP4A3	chr8	142431488	+
99128	CESC	TCGA-C5-A1MJ-01A	DPH7	chr9	140468660	-	ZMYND19	chr9	140481559	-
99128	COAD	TCGA-G4-6309-01A	DPH7	chr9	140473077	-	ZMYND19	chr9	140483170	-
99128	GBM	TCGA-32-1980-01A	DPH7	chr9	140458886	-	ZMYND19	chr9	140483170	-
66777	N/A	CB049417	MTUS2	chr13	29777696	-	DPH7	chr9	140449356	+
66777	N/A	BD311143	PIGR	chr1	207110652	-	DPH7	chr9	140449492	-
66784	PRAD	TCGA-HC-7740	PNPLA7	chr9	140409831	-	DPH7	chr9	140450100	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source