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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MARS2 (NCBI Gene ID:92935)

Gene Summary

Gene Summary

Gene Information	Gene Name: MARS2
	Gene ID: 92935
	Gene Symbol	MARS2
	Gene ID	92935
	Gene Name	methionyl-tRNA synthetase 2, mitochondrial
	Synonyms	COXPD25\|MetRS\|mtMetRS
	Cytomap	2q33.1
	Type of Gene	protein-coding
	Description	methionine--tRNA ligase, mitochondrialmethionine tRNA ligase 2, mitochondrialmethionine--tRNA ligase 2methionine-tRNA synthetase 2, mitochondrial
	Modification date	20200313
	UniProtAcc	Q96GW9

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006418	tRNA aminoacylation for protein translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MARS2	GO:0006431	methionyl-tRNA aminoacylation	15274629

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MARS2	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MARS2[title] AND translation [title] AND human.'

Gene	Title	PMID
MARS2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
READ	MARS2	2.0700272473485	0.03125
HNSC	MARS2	-1.77362037787884	0.0352341516679644
LUAD	MARS2	-5.70960188117261	3.8171822568541e-09
PRAD	MARS2	-2.3666294537261	4.0201920030313e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
LIHC	MARS2	hsa-let-7g-5p	97	0.334034386665966	0.00312781988165043

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MARS2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	MARS2	PIP5K1A	0.800325111	8.72E-12
DLBC	Cell metabolism gene	MARS2	TGS1	0.801031732	8.10E-12
DLBC	Cell metabolism gene	MARS2	PFAS	0.802200513	7.17E-12
DLBC	Cell metabolism gene	MARS2	SUCLA2	0.829492049	3.23E-13
DLBC	Cell metabolism gene	MARS2	GLS	0.836309384	1.37E-13
DLBC	Cell metabolism gene	MARS2	GLUD2	0.843266501	5.44E-14
DLBC	Cell metabolism gene	MARS2	UPF2	0.856673046	8.10E-15
DLBC	Cell metabolism gene	MARS2	NUP153	0.867290656	1.55E-15
DLBC	CGC	MARS2	ATR	0.801922039	7.38E-12
DLBC	CGC	MARS2	PPM1D	0.813495386	2.11E-12
DLBC	CGC	MARS2	BARD1	0.817394553	1.36E-12
DLBC	CGC	MARS2	MLLT10	0.818931271	1.14E-12
DLBC	CGC	MARS2	FUBP1	0.847148498	3.20E-14
DLBC	CGC	MARS2	STAG1	0.85175277	1.67E-14
DLBC	Epifactor	MARS2	ATR	0.801922039	7.38E-12
DLBC	Epifactor	MARS2	PPP4R2	0.804076259	5.89E-12
DLBC	Epifactor	MARS2	RBBP5	0.81203004	2.49E-12
DLBC	Epifactor	MARS2	SHPRH	0.812330625	2.41E-12
DLBC	Epifactor	MARS2	RMI1	0.812909788	2.26E-12
DLBC	Epifactor	MARS2	BARD1	0.817394553	1.36E-12
DLBC	Epifactor	MARS2	PARG	0.818919179	1.14E-12
DLBC	Epifactor	MARS2	MLLT10	0.818931271	1.14E-12
DLBC	Epifactor	MARS2	EPC1	0.825136333	5.49E-13
DLBC	Epifactor	MARS2	SMARCAD1	0.84015054	8.26E-14
DLBC	Epifactor	MARS2	TAF2	0.891878344	1.84E-17
DLBC	Epifactor	MARS2	DDX21	0.893176266	1.41E-17
DLBC	IUPHAR	MARS2	PIP5K1A	0.800325111	8.72E-12
DLBC	IUPHAR	MARS2	ATR	0.801922039	7.38E-12
DLBC	IUPHAR	MARS2	DPP8	0.807601633	4.04E-12
DLBC	IUPHAR	MARS2	ADAM10	0.810466899	2.96E-12
DLBC	IUPHAR	MARS2	HIPK3	0.812012885	2.49E-12
DLBC	IUPHAR	MARS2	PPM1D	0.813495386	2.11E-12
DLBC	IUPHAR	MARS2	ADAM17	0.815244183	1.74E-12
DLBC	IUPHAR	MARS2	MAPK8	0.817455419	1.35E-12
DLBC	IUPHAR	MARS2	TRPM7	0.818629177	1.18E-12
DLBC	IUPHAR	MARS2	SLC30A6	0.820319987	9.70E-13
DLBC	IUPHAR	MARS2	TNKS2	0.820554167	9.44E-13
DLBC	IUPHAR	MARS2	GLS	0.836309384	1.37E-13
DLBC	IUPHAR	MARS2	NR2C2	0.83664521	1.31E-13
DLBC	Kinase	MARS2	ATR	0.801922039	7.38E-12
DLBC	Kinase	MARS2	HIPK3	0.812012885	2.49E-12
DLBC	Kinase	MARS2	MAPK8	0.817455419	1.35E-12
DLBC	Kinase	MARS2	TRPM7	0.818629177	1.18E-12
DLBC	TF	MARS2	ZNF430	0.808152158	3.81E-12
DLBC	TF	MARS2	NFXL1	0.809466295	3.30E-12
DLBC	TF	MARS2	TOPORS	0.817400957	1.36E-12
DLBC	TF	MARS2	NR2C2	0.83664521	1.31E-13
DLBC	TF	MARS2	ETV3	0.839658183	8.82E-14
DLBC	TSG	MARS2	ATR	0.801922039	7.38E-12
DLBC	TSG	MARS2	RASSF3	0.808572967	3.64E-12
DLBC	TSG	MARS2	SHPRH	0.812330625	2.41E-12
DLBC	TSG	MARS2	BARD1	0.817394553	1.36E-12
DLBC	TSG	MARS2	TOPORS	0.817400957	1.36E-12
DLBC	TSG	MARS2	CCAR1	0.823535113	6.64E-13
DLBC	TSG	MARS2	NR2C2	0.83664521	1.31E-13
DLBC	TSG	MARS2	ANAPC1	0.838997338	9.62E-14
TGCT	Cell metabolism gene	MARS2	COL4A3BP	0.805864491	7.06E-37
TGCT	Cell metabolism gene	MARS2	ACER2	0.812024432	7.60E-38
TGCT	Cell metabolism gene	MARS2	RANBP2	0.846594133	5.00E-44
TGCT	CGC	MARS2	MSH2	0.81906119	5.38E-39
TGCT	CGC	MARS2	RANBP2	0.846594133	5.00E-44
TGCT	Epifactor	MARS2	INO80D	0.823753042	8.63E-40
TGCT	Epifactor	MARS2	ZNF217	0.849815871	1.11E-44
TGCT	IUPHAR	MARS2	ACER2	0.812024432	7.60E-38
TGCT	Kinase	MARS2	COL4A3BP	0.805864491	7.06E-37
TGCT	TF	MARS2	ZBTB39	0.801012018	3.86E-36
TGCT	TF	MARS2	ZNF107	0.801750113	2.99E-36
TGCT	TF	MARS2	ZNF121	0.803760637	1.48E-36
TGCT	TF	MARS2	ZNF318	0.807002131	4.70E-37
TGCT	TF	MARS2	SP4	0.808862666	2.41E-37
TGCT	TF	MARS2	ZNF93	0.814617117	2.90E-38
TGCT	TF	MARS2	NFXL1	0.834285058	1.16E-41
TGCT	TF	MARS2	ZNF217	0.849815871	1.11E-44
TGCT	TF	MARS2	ZNF98	0.854797029	1.01E-45
TGCT	TSG	MARS2	MSH2	0.81906119	5.38E-39
THYM	Cell metabolism gene	MARS2	MTR	0.800180789	2.06E-28
THYM	Cell metabolism gene	MARS2	MAT2B	0.800962136	1.67E-28
THYM	Cell metabolism gene	MARS2	SLC25A32	0.805442201	4.91E-29
THYM	Cell metabolism gene	MARS2	ACADM	0.807657836	2.65E-29
THYM	Cell metabolism gene	MARS2	PPAT	0.808931124	1.86E-29
THYM	Cell metabolism gene	MARS2	RQCD1	0.811045773	1.02E-29
THYM	Cell metabolism gene	MARS2	IPPK	0.813043013	5.73E-30
THYM	Cell metabolism gene	MARS2	PGAM4	0.815631763	2.70E-30
THYM	Cell metabolism gene	MARS2	MGAT2	0.821981308	4.03E-31
THYM	Cell metabolism gene	MARS2	POLR2B	0.822380889	3.57E-31
THYM	Cell metabolism gene	MARS2	PIKFYVE	0.823474921	2.55E-31
THYM	Cell metabolism gene	MARS2	NUP205	0.824255537	2.00E-31
THYM	Cell metabolism gene	MARS2	XRN2	0.825680483	1.29E-31
THYM	Cell metabolism gene	MARS2	AGK	0.833450511	1.07E-32
THYM	Cell metabolism gene	MARS2	POLR1B	0.833819863	9.44E-33
THYM	Cell metabolism gene	MARS2	DLAT	0.83864963	1.87E-33
THYM	Cell metabolism gene	MARS2	ARFGEF2	0.842458253	5.04E-34
THYM	Cell metabolism gene	MARS2	ADSS	0.86705294	4.10E-38
THYM	CGC	MARS2	TOP1	0.808722685	1.97E-29
THYM	CGC	MARS2	NBN	0.819194969	9.37E-31
THYM	CGC	MARS2	ATR	0.844913089	2.12E-34
THYM	CGC	MARS2	PALB2	0.846162314	1.36E-34
THYM	CGC	MARS2	CDC73	0.847117698	9.62E-35
THYM	Epifactor	MARS2	SMARCAD1	0.806063975	4.14E-29
THYM	Epifactor	MARS2	RBBP5	0.806360137	3.81E-29
THYM	Epifactor	MARS2	TADA1	0.806730882	3.44E-29
THYM	Epifactor	MARS2	GLYR1	0.807144354	3.06E-29
THYM	Epifactor	MARS2	ADNP	0.807731485	2.60E-29
THYM	Epifactor	MARS2	CUL2	0.818503993	1.15E-30
THYM	Epifactor	MARS2	NBN	0.819194969	9.37E-31
THYM	Epifactor	MARS2	ZNF217	0.820293767	6.73E-31
THYM	Epifactor	MARS2	TAF4	0.821781224	4.29E-31
THYM	Epifactor	MARS2	DDX21	0.837169956	3.09E-33
THYM	Epifactor	MARS2	BRCC3	0.839591514	1.36E-33
THYM	Epifactor	MARS2	TADA2A	0.839599549	1.35E-33
THYM	Epifactor	MARS2	ATR	0.844913089	2.12E-34
THYM	Epifactor	MARS2	CDC73	0.847117698	9.62E-35
THYM	Epifactor	MARS2	UCHL5	0.848670341	5.47E-35
THYM	Epifactor	MARS2	TAF2	0.853840098	7.99E-36
THYM	IUPHAR	MARS2	MTR	0.800180789	2.06E-28
THYM	IUPHAR	MARS2	SLC25A32	0.805442201	4.91E-29
THYM	IUPHAR	MARS2	TOP1	0.808722685	1.97E-29
THYM	IUPHAR	MARS2	PPAT	0.808931124	1.86E-29
THYM	IUPHAR	MARS2	ABCB10	0.81166788	8.52E-30
THYM	IUPHAR	MARS2	PIKFYVE	0.823474921	2.55E-31
THYM	IUPHAR	MARS2	USP14	0.828377561	5.50E-32
THYM	IUPHAR	MARS2	IDE	0.829924338	3.35E-32
THYM	IUPHAR	MARS2	PRMT3	0.836238569	4.23E-33
THYM	IUPHAR	MARS2	ATR	0.844913089	2.12E-34
THYM	Kinase	MARS2	ATR	0.844913089	2.12E-34
THYM	TF	MARS2	MYNN	0.800975666	1.66E-28
THYM	TF	MARS2	IRF2	0.806807726	3.36E-29
THYM	TF	MARS2	GLYR1	0.807144354	3.06E-29
THYM	TF	MARS2	ZNF670	0.807480145	2.79E-29
THYM	TF	MARS2	ADNP	0.807731485	2.60E-29
THYM	TF	MARS2	ZNF217	0.820293767	6.73E-31
THYM	TF	MARS2	PRMT3	0.836238569	4.23E-33
THYM	TF	MARS2	AHCTF1	0.842139072	5.63E-34
THYM	TF	MARS2	ZNF468	0.842788091	4.49E-34
THYM	TF	MARS2	ZNF28	0.853497167	9.10E-36
THYM	TSG	MARS2	CUL2	0.818503993	1.15E-30
THYM	TSG	MARS2	NBN	0.819194969	9.37E-31
THYM	TSG	MARS2	EAF1	0.81995101	7.46E-31
THYM	TSG	MARS2	TANK	0.83540074	5.59E-33
THYM	TSG	MARS2	ATR	0.844913089	2.12E-34
THYM	TSG	MARS2	PALB2	0.846162314	1.36E-34
THYM	TSG	MARS2	CDC73	0.847117698	9.62E-35
UCEC	IUPHAR	MARS2	SLC30A6	0.810834139	3.52E-48
UCS	Cell metabolism gene	MARS2	MTR	0.800180789	2.06E-28
UCS	Cell metabolism gene	MARS2	MAT2B	0.800962136	1.67E-28
UCS	Cell metabolism gene	MARS2	SLC25A32	0.805442201	4.91E-29
UCS	Cell metabolism gene	MARS2	ACADM	0.807657836	2.65E-29
UCS	Cell metabolism gene	MARS2	PPAT	0.808931124	1.86E-29
UCS	Cell metabolism gene	MARS2	RQCD1	0.811045773	1.02E-29
UCS	Cell metabolism gene	MARS2	IPPK	0.813043013	5.73E-30
UCS	Cell metabolism gene	MARS2	PGAM4	0.815631763	2.70E-30
UCS	Cell metabolism gene	MARS2	MGAT2	0.821981308	4.03E-31
UCS	Cell metabolism gene	MARS2	POLR2B	0.822380889	3.57E-31
UCS	Cell metabolism gene	MARS2	PIKFYVE	0.823474921	2.55E-31
UCS	Cell metabolism gene	MARS2	NUP205	0.824255537	2.00E-31
UCS	Cell metabolism gene	MARS2	XRN2	0.825680483	1.29E-31
UCS	Cell metabolism gene	MARS2	AGK	0.833450511	1.07E-32
UCS	Cell metabolism gene	MARS2	POLR1B	0.833819863	9.44E-33
UCS	Cell metabolism gene	MARS2	DLAT	0.83864963	1.87E-33
UCS	Cell metabolism gene	MARS2	ARFGEF2	0.842458253	5.04E-34
UCS	Cell metabolism gene	MARS2	ADSS	0.86705294	4.10E-38
UCS	CGC	MARS2	TOP1	0.808722685	1.97E-29
UCS	CGC	MARS2	NBN	0.819194969	9.37E-31
UCS	CGC	MARS2	ATR	0.844913089	2.12E-34
UCS	CGC	MARS2	PALB2	0.846162314	1.36E-34
UCS	CGC	MARS2	CDC73	0.847117698	9.62E-35
UCS	Epifactor	MARS2	SMARCAD1	0.806063975	4.14E-29
UCS	Epifactor	MARS2	RBBP5	0.806360137	3.81E-29
UCS	Epifactor	MARS2	TADA1	0.806730882	3.44E-29
UCS	Epifactor	MARS2	GLYR1	0.807144354	3.06E-29
UCS	Epifactor	MARS2	ADNP	0.807731485	2.60E-29
UCS	Epifactor	MARS2	CUL2	0.818503993	1.15E-30
UCS	Epifactor	MARS2	NBN	0.819194969	9.37E-31
UCS	Epifactor	MARS2	ZNF217	0.820293767	6.73E-31
UCS	Epifactor	MARS2	TAF4	0.821781224	4.29E-31
UCS	Epifactor	MARS2	DDX21	0.837169956	3.09E-33
UCS	Epifactor	MARS2	BRCC3	0.839591514	1.36E-33
UCS	Epifactor	MARS2	TADA2A	0.839599549	1.35E-33
UCS	Epifactor	MARS2	ATR	0.844913089	2.12E-34
UCS	Epifactor	MARS2	CDC73	0.847117698	9.62E-35
UCS	Epifactor	MARS2	UCHL5	0.848670341	5.47E-35
UCS	Epifactor	MARS2	TAF2	0.853840098	7.99E-36
UCS	IUPHAR	MARS2	MTR	0.800180789	2.06E-28
UCS	IUPHAR	MARS2	SLC25A32	0.805442201	4.91E-29
UCS	IUPHAR	MARS2	TOP1	0.808722685	1.97E-29
UCS	IUPHAR	MARS2	PPAT	0.808931124	1.86E-29
UCS	IUPHAR	MARS2	ABCB10	0.81166788	8.52E-30
UCS	IUPHAR	MARS2	PIKFYVE	0.823474921	2.55E-31
UCS	IUPHAR	MARS2	USP14	0.828377561	5.50E-32
UCS	IUPHAR	MARS2	IDE	0.829924338	3.35E-32
UCS	IUPHAR	MARS2	PRMT3	0.836238569	4.23E-33
UCS	IUPHAR	MARS2	ATR	0.844913089	2.12E-34
UCS	Kinase	MARS2	ATR	0.844913089	2.12E-34
UCS	TF	MARS2	MYNN	0.800975666	1.66E-28
UCS	TF	MARS2	IRF2	0.806807726	3.36E-29
UCS	TF	MARS2	GLYR1	0.807144354	3.06E-29
UCS	TF	MARS2	ZNF670	0.807480145	2.79E-29
UCS	TF	MARS2	ADNP	0.807731485	2.60E-29
UCS	TF	MARS2	ZNF217	0.820293767	6.73E-31
UCS	TF	MARS2	PRMT3	0.836238569	4.23E-33
UCS	TF	MARS2	AHCTF1	0.842139072	5.63E-34
UCS	TF	MARS2	ZNF468	0.842788091	4.49E-34
UCS	TF	MARS2	ZNF28	0.853497167	9.10E-36
UCS	TSG	MARS2	CUL2	0.818503993	1.15E-30
UCS	TSG	MARS2	NBN	0.819194969	9.37E-31
UCS	TSG	MARS2	EAF1	0.81995101	7.46E-31
UCS	TSG	MARS2	TANK	0.83540074	5.59E-33
UCS	TSG	MARS2	ATR	0.844913089	2.12E-34
UCS	TSG	MARS2	PALB2	0.846162314	1.36E-34
UCS	TSG	MARS2	CDC73	0.847117698	9.62E-35

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	MARS2	CTH	-5.51322833858986	0.000102996826171875
STAD	MARS2	YARS	-6.49411565641968	0.000280400272458792
KIRP	MARS2	EARS2	2.04485161641576	0.000364991836249828
BRCA	MARS2	QARS	-4.19270554058168	0.00045278023754438
LUSC	MARS2	LARS	-1.72121981954749	0.000480107205471704
HNSC	MARS2	YARS	1.29642872422682	0.000481783007217019
STAD	MARS2	EPRS	-1.48171581324647	0.000789262883452143
PRAD	MARS2	MTR	-1.94237856790995	0.00102692827260821
LUSC	MARS2	RARS2	1.87851633718952	0.00105278618568408
THCA	MARS2	QARS	-1.4601543520666	0.00171161769998529
LUSC	MARS2	MTR	-7.73168871169615	0.00210845814063025
LIHC	MARS2	MTR	-1.24864221980252	0.00313782336931997
HNSC	MARS2	MTR	-1.06746708151172	0.00373573799811311
KIRP	MARS2	RARS2	-1.62015129839089	0.00733334058895707
CHOL	MARS2	IARS	-2.92341608141499	0.01171875
LIHC	MARS2	LARS	-1.57612943170265	1.09871251804152e-08
KICH	MARS2	MTFMT	2.05895643036764	1.13248825073242e-06
LUAD	MARS2	LARS	-1.89171706205171	1.25525807323939e-06
THCA	MARS2	YARS	-1.52851760350795	1.38467683131598e-09
LIHC	MARS2	EPRS	-7.10731017811505	2.28054594243154e-08
KICH	MARS2	YARS	-2.00632816869948	2.98023223876953e-07
LUSC	MARS2	EARS2	-4.79437223180067	3.23227619897643e-09
PRAD	MARS2	QARS	1.84374784424986	3.33417295851411e-06
LIHC	MARS2	IARS	-1.16847098939898	3.43009058766818e-06
BRCA	MARS2	YARS	-2.58863291399932	3.63754942015711e-21
LUAD	MARS2	EARS2	-4.660053370012	3.79251210274868e-11
BLCA	MARS2	EARS2	-4.74352280775662	3.814697265625e-06
STAD	MARS2	EARS2	-1.69983591205674	4.39747236669064e-05
PRAD	MARS2	EPRS	-1.76339127457265	9.52775218277559e-05
KIRP	MARS2	CTH	-2.95139146981947	9.63918864727021e-08

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MARS2

APP, FCGR2B, MRPL4, GCDH, FAM219A, ALDOC, SLC9A3R2, SMURF2, HSPD1, C17orf53, NDUFS7, YBEY, STAU1, HSCB, CLPP, OGT, ATG7, SSX7, BCKDHB, SIRT3, SIPA1L2, MALSU1, GCSAML, MTSS1L, GPR182, ACSM5, MTHFD1L, MAG, HINT2, NDUFB11, UQCRFS1, CDKN2C, FAM19A2, CLUH, TRUB2, MYL10, SSC4D, OPTN,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MARS2	chr2	198569935	C	T	single_nucleotide_variant	Likely_benign	not_provided
MARS2	chr2	198569951	G	T	single_nucleotide_variant	Likely_benign	not_provided
MARS2	chr2	198570104	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
MARS2	chr2	198570129	C	CATGCTGCGAACGTCCGTCCTCCGCCTGCTAGGACGCACGGGGGCTAGTAGGCTGTCTCTCCTGGAGGACTTCGGCCCACGCTACTACAGTTCGGGCTCCCTCAGTGCCGGCGATGATGCTTGTGATGTGCGCGCCTACTTCACTACACCCATTTTCTACGTGAACGCGGCGCCGCACATCGGGCACCTGTACTCGGCACTACTGGCGGACGCCCTATGCCGCCACCGTCGCCTCCGAGGTCCCAGCACGGCCGC	Duplication	Pathogenic	Ataxia,_spastic,_3,_autosomal_recessive	SO:0001582\|initiatior_codon_variant,SO:0002073\|no_sequence_alteration	SO:0001582\|initiatior_codon_variant,SO:0002073\|no_sequence_alteration
MARS2	chr2	198570134	T	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198570141	G	A	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198570153	C	G	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198570172	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198570189	C	T	single_nucleotide_variant	Benign/Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198570216	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198570222	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198570253	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198570274	A	G	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198570285	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198570304	C	T	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198570311	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198570324	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198570447	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198570451	C	T	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198570470	G	T	single_nucleotide_variant	Uncertain_significance	Ataxia,_spastic,_3,_autosomal_recessive	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198570497	A	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198570538	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198570539	GC	TA	Indel	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198570540	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198570553	C	T	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_25	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198570600	C	T	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198570618	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198570623	A	G	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_25	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198570678	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198570679	C	T	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_25	SO:0001587\|nonsense	SO:0001587\|nonsense
MARS2	chr2	198570735	A	G	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198570809	GGGGCAACCCTCAGGCGATCACCCCCGAACCATTTCATCACGTAGTTCTTCAGTGGCTGGACGAGGAGCTGCCCGACCTGTCCGTGTCTCGCAGAAGTAGCCACTTGCACTGGGGCATTCCGGTGCCCGGGGATGATTCGCAGACCATCTATGTATGGCTGGATGCCCTGGTCAACTACCTCACTGTAATTGGCTACCCAAATGCTGAGTTCAAATCTTGGTGGCCGGCCACCTCTCATATCATAGGTAAGGACA	G	Deletion	Pathogenic	Ataxia,_spastic,_3,_autosomal_recessive	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
MARS2	chr2	198570826	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198570849	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198570850	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198570869	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198570877	C	T	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198570928	C	T	single_nucleotide_variant	Uncertain_significance	Ataxia,_spastic,_3,_autosomal_recessive	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198570930	G	C	single_nucleotide_variant	Benign/Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198570999	TG	T	Deletion	Likely_pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
MARS2	chr2	198571057	A	G	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_25	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198571062	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198571158	CTG	C	Microsatellite	Pathogenic	Combined_oxidative_phosphorylation_deficiency_25	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
MARS2	chr2	198571168	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198571223	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198571280	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198571302	G	C	single_nucleotide_variant	Benign/Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198571323	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198571336	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198571369	A	T	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
MARS2	chr2	198571370	G	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198571376	A	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198571382	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198571416	C	T	single_nucleotide_variant	Benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198571426	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198571511	C	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198571539	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198571709	T	C	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198571744	C	T	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198571850	G	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198571890	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MARS2	chr2	198571904	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MARS2	chr2	198572076	A	ATTC	Duplication	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
MARS2	chr2	198572157	ACAGTGTTGCTAATG	A	Deletion	Likely_benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MARS2	KIRP	chr2	198571900	198571900	C	T	Missense_Mutation	p.H591Y	5
MARS2	BLCA	chr2	198570227	198570227	C	T	Missense_Mutation	p.S33F	4
MARS2	KIRP	chr2	198570300	198570300	G	T	Silent	p.A57A	4
MARS2	THCA	chr2	198571775	198571775	G	T	Missense_Mutation	p.G549V	4
MARS2	ESCA	chr2	198571219	198571219	C	T	Missense_Mutation	p.R364C	3
MARS2	HNSC	chr2	198570720	198570720	C	G	Silent	p.L197L	3
MARS2	BLCA	chr2	198571355	198571355	G	T	Missense_Mutation		3
MARS2	STAD	chr2	198570830	198570830	C	-	Frame_Shift_Del	p.T234fs	3
MARS2	LUAD	chr2	198570930	198570930	G	T	Silent	p.P267P	3
MARS2	ACC	chr2	198571904	198571904	G	A	Missense_Mutation	p.R592Q	3
MARS2	BRCA	chr2	198570604	198570604	C	T	Silent	p.L159	3
MARS2	HNSC	chr2	198571571	198571571	G	A	Missense_Mutation	p.R481Q	3
MARS2	CESC	chr2	198571760	198571760	C	T	Missense_Mutation		2
MARS2	HNSC	chr2	198570156	198570156	G	T	Silent	p.L9L	2
MARS2	SKCM	chr2	198571316	198571316	A	G	Missense_Mutation	p.N396S	2
MARS2	CESC	chr2	198570947	198570947	C	T	Missense_Mutation		2
MARS2	STAD	chr2	198570914	198570914	T	C	Missense_Mutation		2
MARS2	UCEC	chr2	198570281	198570281	T	C	Missense_Mutation	p.I51T	2
MARS2	ESCA	chr2	198571905	198571905	G	T	Silent		2
MARS2	LUAD	chr2	198571111	198571111	G	T	Missense_Mutation	p.G328C	2
MARS2	UCEC	chr2	198570554	198570554	G	T	Missense_Mutation	p.R142L	2
MARS2	PAAD	chr2	198570573	198570573	G	A	Silent	p.Q148Q	2
MARS2	KIRC	chr2	198571443	198571443	G	A	Silent	p.P438P	2
MARS2	STAD	chr2	198570914	198570914	T	C	Missense_Mutation	p.L262S	2
MARS2	ESCA	chr2	198571219	198571219	C	T	Missense_Mutation		2
MARS2	LUAD	chr2	198571470	198571470	T	A	Nonsense_Mutation	p.Y447*	2
MARS2	UCEC	chr2	198571078	198571078	G	A	Missense_Mutation	p.A317T	2
MARS2	STAD	chr2	198570341	198570341	C	T	Missense_Mutation	p.A71V	2
MARS2	ESCA	chr2	198571905	198571905	G	T	Silent	p.R592R	2
MARS2	LUAD	chr2	198571261	198571261	G	T	Missense_Mutation	p.G378C	2
MARS2	UCEC	chr2	198571612	198571612	C	T	Silent	p.L495	2
MARS2	STAD	chr2	198571290	198571290	T	C	Silent	p.Y387Y	2
MARS2	UCEC	chr2	198571779	198571779	G	A	Silent	p.E550	2
MARS2	HNSC	chr2	198570406	198570406	G	C	Missense_Mutation	p.D93H	2
MARS2	SARC	chr2	198571474	198571474	C	G	Missense_Mutation		2
MARS2	LGG	chr2	198570143	198570143	C	T	Missense_Mutation	p.S5F	2
MARS2	LUAD	chr2	198570480	198570480	C	G	Silent	p.V117V	2
MARS2	UCEC	chr2	198571806	198571806	A	G	Silent	p.G559	2
MARS2	HNSC	chr2	198570421	198570421	A	C	Missense_Mutation	p.K98Q	2
MARS2	SARC	chr2	198571474	198571474	C	G	Missense_Mutation	p.L449V	2
MARS2	STAD	chr2	198570228	198570228	C	T	Silent	p.S33S	2
MARS2	SKCM	chr2	198570890	198570890	C	T	Missense_Mutation	p.S254F	2
MARS2	LUAD	chr2	198571774	198571774	G	T	Nonsense_Mutation	p.G549*	2
MARS2	SKCM	chr2	198570721	198570721	G	A	Missense_Mutation	p.E198K	2
MARS2	LIHC	chr2	198570872	198570872	A	T	Missense_Mutation		2
MARS2	LUAD	chr2	198570447	198570447	G	T	Silent	p.A106A	2
MARS2	CESC	chr2	198571412	198571412	G	A	Missense_Mutation		2
MARS2	SKCM	chr2	198570826	198570826	A	G	Missense_Mutation	p.I233V	2
MARS2	LUAD	chr2	198570892	198570892	G	T	Missense_Mutation	p.V255L	2
MARS2	LIHC	chr2	198571647	198571647	G	-	Frame_Shift_Del	p.L506fs	1
MARS2	LUAD	chr2	198571055	198571055	G	A	Missense_Mutation	p.G309D	1
MARS2	UCEC	chr2	198570581	198570581	G	-	Frame_Shift_Del	p.W151fs	1
MARS2	OV	chr2	198571020	198571020	C	G	Missense_Mutation	p.F297L	1
MARS2	BLCA	chr2	198570809	198570809	G	A	Missense_Mutation		1
MARS2	HNSC	chr2	198570421	198570421	A	C	Missense_Mutation		1
MARS2	ESCA	chr2	198571905	198571905	G	T	Silent	p.R592	1
MARS2	LIHC	chr2	198570204	198570204	C	-	Frame_Shift_Del	p.G25fs	1
MARS2	LUAD	chr2	198570234	198570234	T	C	Silent	p.S35S	1
MARS2	PAAD	chr2	198570573	198570573	G	A	Silent		1
MARS2	HNSC	chr2	198570156	198570156	G	T	Silent		1
MARS2	CESC	chr2	198571355	198571355	G	A	Missense_Mutation	p.R409Q	1
MARS2	KIRC	chr2	198570416	198570416	G	C	Missense_Mutation	p.G96A	1
MARS2	STAD	chr2	198570341	198570341	C	T	Missense_Mutation		1
MARS2	LUAD	chr2	198571382	198571382	C	G	Missense_Mutation	p.S418C	1
MARS2	BLCA	chr2	198570649	198570649	G	A	Missense_Mutation		1
MARS2	HNSC	chr2	198570969	198570969	G	T	Silent		1
MARS2	CESC	chr2	198571412	198571412	G	A	Missense_Mutation	p.C428Y	1
MARS2	LUAD	chr2	198570940	198570940	G	T	Missense_Mutation	p.D271Y	1
MARS2	HNSC	chr2	198570695	198570695	C	T	Missense_Mutation		1
MARS2	PRAD	chr2	198571628	198571628	C	A	Missense_Mutation	p.P500Q	1
MARS2	BLCA	chr2	198570427	198570427	C	G	Missense_Mutation	p.Q100E	1
MARS2	CESC	chr2	198571760	198571760	C	T	Missense_Mutation	p.S544L	1
MARS2	LUAD	chr2	198571610	198571610	A	T	Missense_Mutation	p.K494M	1
MARS2	HNSC	chr2	198570956	198570956	T	A	Missense_Mutation		1
MARS2	SARC	chr2	198570511	198570511	G	T	Missense_Mutation		1
MARS2	COAD	chr2	198570172	198570172	G	A	Missense_Mutation	p.A15T	1
MARS2	GBM	chr2	198570303	198570303	G	A	Silent	p.P58P	1
MARS2	LUAD	chr2	198570844	198570844	C	T	Missense_Mutation	p.H239Y	1
MARS2	BLCA	chr2	198570809	198570809	G	A	Missense_Mutation	p.R227Q	1
MARS2	COAD	chr2	198570761	198570761	A	G	Missense_Mutation	p.Y211C	1
MARS2	GBM	chr2	198570300	198570300	G	T	Silent		1
MARS2	LUAD	chr2	198571570	198571570	C	A	Silent	p.R481R	1
MARS2	BLCA	chr2	198571355	198571355	G	T	Missense_Mutation	p.R409L	1
MARS2	COAD	chr2	198571223	198571223	A	G	Missense_Mutation	p.Y365C	1
MARS2	LGG	chr2	198571649	198571650	-	A	Frame_Shift_Ins	p.D507fs	1
MARS2	HNSC	chr2	198570720	198570720	C	G	Silent		1
MARS2	LUAD	chr2	198570150	198570150	C	T	Silent	p.L7L	1
MARS2	BLCA	chr2	198570649	198570649	G	A	Missense_Mutation	p.E174K	1
MARS2	HNSC	chr2	198570695	198570695	C	T	Missense_Mutation	p.S189L	1
MARS2	COAD	chr2	198571589	198571589	T	C	Missense_Mutation	p.V487A	1
MARS2	LGG	chr2	198570143	198570143	C	T	Missense_Mutation		1
MARS2	STAD	chr2	198571099	198571099	C	A	Missense_Mutation	p.L324M	1
MARS2	ACC	chr2	198570807	198570807	G	T	Silent	p.L226L	1
MARS2	HNSC	chr2	198571486	198571486	G	T	Missense_Mutation		1
MARS2	LUAD	chr2	198571112	198571112	G	A	Missense_Mutation	p.G328D	1
MARS2	HNSC	chr2	198570956	198570956	T	A	Missense_Mutation	p.I276N	1
MARS2	COAD	chr2	198571601	198571601	C	T	Missense_Mutation	p.A491V	1
MARS2	THCA	chr2	198571775	198571775	G	T	Missense_Mutation		1
MARS2	BLCA	chr2	198570427	198570427	C	G	Missense_Mutation		1
MARS2	HNSC	chr2	198571571	198571571	G	A	Missense_Mutation		1
MARS2	LUSC	chr2	198570870	198570870	C	T	Silent	p.D247D	1
MARS2	COAD	chr2	198571903	198571903	C	T	Missense_Mutation	p.R592W	1
MARS2	LIHC	chr2	198570872	198570872	A	T	Missense_Mutation	p.E248V	1
MARS2	MESO	chr2	198570173	198570173	C	T	Missense_Mutation	p.A15V	1
MARS2	BLCA	chr2	198570227	198570227	C	T	Missense_Mutation		1
MARS2	HNSC	chr2	198570406	198570406	G	C	Missense_Mutation		1

Copy number variation (CNV) of MARS2
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Fusion gene breakpoints (product of the structural variants (SVs)) across MARS2
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Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	MARS2	0.000611130729123959	0.017
KIRC	MARS2	0.000758577036899731	0.02
SARC	MARS2	0.0045864889106447	0.12
THYM	MARS2	0.0214299205174718	0.54
ACC	MARS2	0.0357750528286449	0.86
READ	MARS2	0.037340140451339	0.86
LIHC	MARS2	0.0416813453434083	0.92

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	MARS2	0.00414164944374831	0.13
KIRC	MARS2	9.65633039996712e-05	0.0032
PAAD	MARS2	0.0113467584842968	0.35

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1969645	Ataxia, Spastic, 3, Autosomal Recessive	4	CTD_human;GENOMICS_ENGLAND;ORPHANET
C4225329	COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 25	1	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT