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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: EEF1E1 (NCBI Gene ID:9521)

Gene Summary

Gene Summary

Gene Information	Gene Name: EEF1E1
	Gene ID: 9521
	Gene Symbol	EEF1E1
	Gene ID	9521
	Gene Name	eukaryotic translation elongation factor 1 epsilon 1
	Synonyms	AIMP3\|P18
	Cytomap	6p24.3
	Type of Gene	protein-coding
	Description	eukaryotic translation elongation factor 1 epsilon-1ARS-interacting multifunctional protein 3aminoacyl tRNA synthetase complex-interacting multifunctional protein 3multisynthase complex auxiliary component p18p18 component of aminoacyl-tRNA synthetase
	Modification date	20200313
	UniProtAcc	O43324

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EEF1E1	GO:2000774	positive regulation of cellular senescence	25465621

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'EEF1E1[title] AND translation [title] AND human.'

Gene	Title	PMID
EEF1E1	Absence of somatic mutation of a tumor suppressor gene eukaryotic translation elongation factor 1, epsilon-1 (EEF1E1), in common human cancers	19024604

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	EEF1E1	-1.3313725927284	0.000655351190157038
PRAD	EEF1E1	-1.69363995345609	0.000901881259820622
LUSC	EEF1E1	-2.00467456217075	1.65402843598856e-05
LUAD	EEF1E1	-5.69272597450276	2.37450106160718e-08
BRCA	EEF1E1	-2.07439081740763	3.45958438128459e-11
KIRC	EEF1E1	-3.27101773387926	8.11678117840128e-09

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LGG	EEF1E1	0.10550476	0.006810022

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with EEF1E1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
COAD	IUPHAR	EEF1E1	RIOK1	0.806033104	1.80E-76
COAD	Kinase	EEF1E1	RIOK1	0.806033104	1.80E-76
KICH	Cell metabolism gene	EEF1E1	CDK19	0.804546303	7.55E-22
KICH	Cell metabolism gene	EEF1E1	TXNDC12	0.805095642	6.74E-22
KICH	Cell metabolism gene	EEF1E1	ODC1	0.805718395	5.94E-22
KICH	Cell metabolism gene	EEF1E1	NPAS2	0.808394791	3.41E-22
KICH	Cell metabolism gene	EEF1E1	GLDC	0.808589634	3.27E-22
KICH	Cell metabolism gene	EEF1E1	NAT2	0.808765004	3.15E-22
KICH	Cell metabolism gene	EEF1E1	GPC5	0.816642714	5.83E-23
KICH	Cell metabolism gene	EEF1E1	PIGF	0.816776221	5.66E-23
KICH	Cell metabolism gene	EEF1E1	SCLY	0.819383427	3.18E-23
KICH	Cell metabolism gene	EEF1E1	POLR3C	0.820054375	2.74E-23
KICH	Cell metabolism gene	EEF1E1	SSR1	0.827117653	5.43E-24
KICH	Cell metabolism gene	EEF1E1	BPNT1	0.833334616	1.23E-24
KICH	Cell metabolism gene	EEF1E1	TYRP1	0.833614079	1.15E-24
KICH	Cell metabolism gene	EEF1E1	HS6ST2	0.845053998	6.28E-26
KICH	Cell metabolism gene	EEF1E1	AFMID	0.847580281	3.20E-26
KICH	Cell metabolism gene	EEF1E1	PRODH	0.84800326	2.86E-26
KICH	Cell metabolism gene	EEF1E1	NME7	0.85710547	2.25E-27
KICH	Cell metabolism gene	EEF1E1	GALNT14	0.872048694	2.32E-29
KICH	CGC	EEF1E1	USP44	0.801005138	1.54E-21
KICH	CGC	EEF1E1	FGFR4	0.803083949	1.02E-21
KICH	CGC	EEF1E1	EPHA7	0.811135919	1.91E-22
KICH	CGC	EEF1E1	SMARCE1	0.816021506	6.68E-23
KICH	CGC	EEF1E1	GPC5	0.816642714	5.83E-23
KICH	CGC	EEF1E1	SPOP	0.830179145	2.63E-24
KICH	Epifactor	EEF1E1	USP44	0.801005138	1.54E-21
KICH	Epifactor	EEF1E1	NPAS2	0.808394791	3.41E-22
KICH	Epifactor	EEF1E1	BRE	0.815082169	8.20E-23
KICH	Epifactor	EEF1E1	SMARCE1	0.816021506	6.68E-23
KICH	Epifactor	EEF1E1	SPOP	0.830179145	2.63E-24
KICH	Epifactor	EEF1E1	HDAC2	0.831030418	2.15E-24
KICH	Epifactor	EEF1E1	DDX50	0.836529375	5.59E-25
KICH	Epifactor	EEF1E1	ANP32E	0.84413627	7.99E-26
KICH	Epifactor	EEF1E1	HAT1	0.846468914	4.31E-26
KICH	Epifactor	EEF1E1	NSL1	0.855576341	3.49E-27
KICH	IUPHAR	EEF1E1	PTH2R	0.800525585	1.70E-21
KICH	IUPHAR	EEF1E1	FGFR4	0.803083949	1.02E-21
KICH	IUPHAR	EEF1E1	CDK19	0.804546303	7.55E-22
KICH	IUPHAR	EEF1E1	ODC1	0.805718395	5.94E-22
KICH	IUPHAR	EEF1E1	PTGER1	0.80593623	5.68E-22
KICH	IUPHAR	EEF1E1	WNK4	0.806781883	4.77E-22
KICH	IUPHAR	EEF1E1	NR1H4	0.8107395	2.08E-22
KICH	IUPHAR	EEF1E1	EPHA7	0.811135919	1.91E-22
KICH	IUPHAR	EEF1E1	HUNK	0.817020541	5.37E-23
KICH	IUPHAR	EEF1E1	SLC39A10	0.82164204	1.92E-23
KICH	IUPHAR	EEF1E1	HDAC2	0.831030418	2.15E-24
KICH	IUPHAR	EEF1E1	PREPL	0.831823341	1.77E-24
KICH	IUPHAR	EEF1E1	LEPR	0.835980514	6.41E-25
KICH	IUPHAR	EEF1E1	RBBP9	0.836412081	5.76E-25
KICH	IUPHAR	EEF1E1	KATNA1	0.840398594	2.11E-25
KICH	IUPHAR	EEF1E1	SLC12A1	0.841623405	1.54E-25
KICH	IUPHAR	EEF1E1	HAT1	0.846468914	4.31E-26
KICH	IUPHAR	EEF1E1	RIOK1	0.848804282	2.30E-26
KICH	IUPHAR	EEF1E1	GABRA2	0.851791177	1.01E-26
KICH	IUPHAR	EEF1E1	KCNJ16	0.854275304	5.05E-27
KICH	IUPHAR	EEF1E1	SLC35A1	0.861675876	5.88E-28
KICH	IUPHAR	EEF1E1	NEK11	0.872252937	2.17E-29
KICH	Kinase	EEF1E1	FGFR4	0.803083949	1.02E-21
KICH	Kinase	EEF1E1	CDK19	0.804546303	7.55E-22
KICH	Kinase	EEF1E1	WNK4	0.806781883	4.77E-22
KICH	Kinase	EEF1E1	EPHA7	0.811135919	1.91E-22
KICH	Kinase	EEF1E1	HUNK	0.817020541	5.37E-23
KICH	Kinase	EEF1E1	RIOK1	0.848804282	2.30E-26
KICH	Kinase	EEF1E1	NEK11	0.872252937	2.17E-29
KICH	TF	EEF1E1	ZNF286A	0.804372997	7.82E-22
KICH	TF	EEF1E1	TFAP2B	0.804638081	7.41E-22
KICH	TF	EEF1E1	ZNF25	0.806272907	5.29E-22
KICH	TF	EEF1E1	TBP	0.806688483	4.86E-22
KICH	TF	EEF1E1	NPAS2	0.808394791	3.41E-22
KICH	TF	EEF1E1	IRX2	0.808788404	3.14E-22
KICH	TF	EEF1E1	NR1H4	0.8107395	2.08E-22
KICH	TF	EEF1E1	SALL2	0.814373014	9.56E-23
KICH	TF	EEF1E1	ZNF883	0.820458224	2.50E-23
KICH	TF	EEF1E1	DZIP1	0.837402217	4.50E-25
KICH	TF	EEF1E1	FOXJ1	0.84298735	1.08E-25
KICH	TSG	EEF1E1	HACE1	0.803939235	8.54E-22
KICH	TSG	EEF1E1	CACNA2D3	0.804719677	7.28E-22
KICH	TSG	EEF1E1	NPAS2	0.808394791	3.41E-22
KICH	TSG	EEF1E1	SALL2	0.814373014	9.56E-23
KICH	TSG	EEF1E1	RASAL1	0.815170424	8.05E-23
KICH	TSG	EEF1E1	GPC5	0.816642714	5.83E-23
KICH	TSG	EEF1E1	OSCP1	0.81791827	4.40E-23
KICH	TSG	EEF1E1	SPOP	0.830179145	2.63E-24
KICH	TSG	EEF1E1	CASC2	0.836076966	6.26E-25
KICH	TSG	EEF1E1	HRG	0.845463903	5.63E-26
KICH	TSG	EEF1E1	CASC1	0.846407551	4.38E-26
KICH	TSG	EEF1E1	PRODH	0.84800326	2.86E-26
KICH	TSG	EEF1E1	APITD1	0.853488448	6.31E-27
KICH	TSG	EEF1E1	XRCC5	0.853880954	5.65E-27
KICH	TSG	EEF1E1	IFT88	0.895013189	5.85E-33
UVM	Cell metabolism gene	EEF1E1	GLO1	0.832590655	1.04E-21
UVM	Epifactor	EEF1E1	HMGN4	0.822575391	8.22E-21

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type

Translation factor

Interacting protein coding gene

adj.pval

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with EEF1E1

AIMP2, EPRS, KARS, IARS, DARS, MARS, QARS, RARS, AIMP1, ITGA4, gag, DNAJA1, EIF2S1, EIF4G1, RPL15, RPL18, RPL7A, RPLP0, EIF2S3, HNRNPA2B1, IQGAP1, CCAR2, RPL13, RPL21, RPL23A, RPL24, RPL26, RPL27A, RPL36, HUWE1, CALCOCO2, NAT9, BLK, SDCBP, ATP6V1A, ATP6V1B2, CIAPIN1, TWF1, UBA1, LARS, RNASEH2C, MED4, PKN2, RAF1, STRN, CHAMP1, Atp7a, Junb, Sdccag8, Dlgap4, MCM2, COX15, DLD, HSD17B10, PDHA1, SOAT1, VDAC1, HIF1AN, EGLN3, AAR2, PIH1D1, EFTUD2, HEXIM1, MEPCE, LARP7, SNAI1, RECQL4, KRT17, KIAA1429, HIST1H4A, MAP3K14, P2RY6, MAB21L2, ITFG1, ARAF, NFX1, WWP2, PLEKHA4, ENG, HCVgp1, ZC3H18, MTA2, CIT, ARHGAP29, CDC42, Apc2, JMJD6, UFL1, DDRGK1, MARCKS, UBQLN1, FBXW7, CTSL, nsp13, nsp5, ORF10, ORF3a, TAX1BP1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
EEF1E1	LIHC	chr6	8090388	8090388	A	-	Frame_Shift_Del	p.S139fs	3
EEF1E1	UCS	chr6	8090502	8090502	A	G	Missense_Mutation	p.Y101H	3
EEF1E1	LUAD	chr6	8097553	8097553	C	-	Frame_Shift_Del	p.V79fs	3
EEF1E1	PRAD	chr6	8097597	8097597	G	A	Missense_Mutation	p.T64I	3
EEF1E1	UCEC	chr6	8097660	8097660	C	T	Missense_Mutation	p.G43E	3
EEF1E1	LIHC	chr6	8097609	8097609	A	G	Missense_Mutation	p.L60S	2
EEF1E1	CESC	chr6	8097678	8097678	T	C	Missense_Mutation		2
EEF1E1	UCEC	chr6	8097669	8097669	C	A	Missense_Mutation	p.S40I	2
EEF1E1	UCEC	chr6	8102693	8102693	T	G	Missense_Mutation	p.K21T	2
EEF1E1	STAD	chr6	8097577	8097577	C	T	Missense_Mutation	p.V71I	2
EEF1E1	STAD	chr6	8097522	8097522	T	C	Missense_Mutation	p.N89S	2
EEF1E1	ESCA	chr6	8090462	8090462	G	T	Missense_Mutation	p.T114K	2
EEF1E1	STAD	chr6	8097536	8097536	C	T	Silent	p.G84G	2
EEF1E1	KIRC	chr6	8080190	8080190	G	A	Missense_Mutation	p.P153L	2
EEF1E1	SARC	chr6	8090472	8090472	A	G	Missense_Mutation		2
EEF1E1	SKCM	chr6	8097578	8097578	G	A	Silent	p.I70I	2
EEF1E1	LIHC	chr6	8097609	8097609	A	G	Missense_Mutation		2
EEF1E1	SKCM	chr6	8097525	8097525	T	C	Missense_Mutation	p.K88R	2
EEF1E1	UCEC	chr6	8090499	8090499	G	T	Missense_Mutation	p.L102I	2
EEF1E1	SKCM	chr6	8080164	8080164	C	A	Missense_Mutation	p.V162F	1
EEF1E1	HNSC	chr6	8102739	8102739	C	G	Missense_Mutation		1
EEF1E1	CESC	chr6	8097678	8097678	T	C	Missense_Mutation	p.N37S	1
EEF1E1	SKCM	chr6	8102719	8102719	C	T	Silent	p.K12K	1
EEF1E1	HNSC	chr6	8102739	8102739	C	G	Missense_Mutation	p.E6Q	1
EEF1E1	LUAD	chr6	8097506	8097506	C	G	Silent	p.L94L	1
EEF1E1	CHOL	chr6	8097530	8097530	G	T	Silent		1
EEF1E1	STAD	chr6	8097577	8097577	C	T	Missense_Mutation		1
EEF1E1	HNSC	chr6	8080226	8080226	T	C	Missense_Mutation	p.N141S	1
EEF1E1	UCS	chr6	8090502	8090502	A	G	Missense_Mutation		1
EEF1E1	LUAD	chr6	8080245	8080245	C	G	Missense_Mutation	p.E135Q	1
EEF1E1	CHOL	chr6	8097530	8097530	G	T	Silent	p.S86S	1
EEF1E1	HNSC	chr6	8102741	8102741	G	A	Missense_Mutation	p.A5V	1
EEF1E1	ESCA	chr6	8080173	8080173	G	T	Missense_Mutation	p.L159M	1
EEF1E1	HNSC	chr6	8102742	8102742	C	A	Missense_Mutation	p.A5S	1
EEF1E1	HNSC	chr6	8102741	8102742	GC	AA	Missense_Mutation	p.A5L	1
EEF1E1	BLCA	chr6	8090438	8090438	T	C	Missense_Mutation		1
EEF1E1	PRAD	chr6	8097604	8097604	C	A	Missense_Mutation	p.G62W	1
EEF1E1	ESCA	chr6	8090462	8090462	G	T	Missense_Mutation		1
EEF1E1	STAD	chr6	8090483	8090483	T	C	Missense_Mutation	p.Y107C	1
EEF1E1	BLCA	chr6	8080128	8080128	G	T	Missense_Mutation		1
EEF1E1	ESCA	chr6	8080173	8080173	G	T	Missense_Mutation		1
EEF1E1	TGCT	chr6	8090389	8090389	A	T	Missense_Mutation		1
EEF1E1	KIRP	chr6	8102676	8102676	C	A	Nonsense_Mutation		1
EEF1E1	BLCA	chr6	8080237	8080237	C	A	Missense_Mutation		1
EEF1E1	ESCA	chr6	8079689	8079689	C	T	RNA	.	1
EEF1E1	THYM	chr6	8080129	8080129	G	A	Silent		1
EEF1E1	BLCA	chr6	8080237	8080237	C	A	Missense_Mutation	p.E137D	1
EEF1E1	HNSC	chr6	8102741	8102741	G	A	Missense_Mutation		1
EEF1E1	LIHC	chr6	8090503	8090503	T	C	Silent	p.S100S	1
EEF1E1	CESC	chr6	8102777	8102777	G	A	Missense_Mutation		1
EEF1E1	SKCM	chr6	8080218	8080218	G	A	Missense_Mutation	p.R144C	1
EEF1E1	HNSC	chr6	8102742	8102742	C	A	Missense_Mutation		1

Copy number variation (CNV) of EEF1E1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across EEF1E1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
78297	SKCM	TCGA-EE-A3JI-06A	CDYL	chr6	4892613	+	EEF1E1	chr6	8097700	-
101817	BRCA	TCGA-A8-A0AD-01A	EEF1E1	chr6	8095611	-	EYS	chr6	66205886	-
78297	COAD	TCGA-A6-6654-01A	GMDS	chr6	2116005	-	EEF1E1	chr6	8097700	-
78297	SARC	TCGA-DX-A1L2-01A	INPP4A	chr2	99193606	+	EEF1E1	chr6	8080263	-
78297	BRCA	TCGA-C8-A8HQ-01A	PSMG4	chr6	3259430	-	EEF1E1	chr6	8080263	-
78313	GBM	TCGA-06-5412-01A	RREB1	chr6	7108293	+	EEF1E1	chr6	8097700	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	EEF1E1	0.00165993610323977	0.046
TGCT	EEF1E1	0.0309006785983058	0.83

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	EEF1E1	0.0219604599306282	0.66
KIRC	EEF1E1	0.00350483247531413	0.11
PAAD	EEF1E1	0.00285065312666413	0.091
HNSC	EEF1E1	0.00184673890363365	0.061

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source