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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RBM8A (NCBI Gene ID:9939)

Gene Summary

Gene Summary

Gene Information	Gene Name: RBM8A
	Gene ID: 9939
	Gene Symbol	RBM8A
	Gene ID	9939
	Gene Name	RNA binding motif protein 8A
	Synonyms	BOV-1A\|BOV-1B\|BOV-1C\|C1DELq21.1\|DEL1q21.1\|MDS014\|RBM8\|RBM8B\|TAR\|Y14\|ZNRP\|ZRNP1
	Cytomap	1q21.1
	Type of Gene	protein-coding
	Description	RNA-binding protein 8ABOV-1RNA binding motif protein 8BRNA-binding protein Y14binder of OVCA1binder of OVCA1-1ribonucleoprotein RBM8ribonucleoprotein RBM8A
	Modification date	20200313
	UniProtAcc	Q9Y5S9

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RBM8A	GO:0000398	mRNA splicing, via spliceosome	29301961

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RBM8A	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RBM8A[title] AND translation [title] AND human.'

Gene	Title	PMID
RBM8A	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	RBM8A	-3.06006403111345	2.58704546629954e-06
KICH	RBM8A	2.62055927587015	2.98023223876953e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
UCEC	RBM8A	hsa-miR-193b-3p	76	-0.403208556149733	0.0187368267185225

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RBM8A (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	RBM8A	B4GALT3	0.815833521	8.68E-12
CHOL	Cell metabolism gene	RBM8A	POLR3C	0.864416519	2.00E-14
CHOL	Epifactor	RBM8A	VPS72	0.823957238	3.59E-12
CHOL	Epifactor	RBM8A	ZNF687	0.84321411	3.65E-13
CHOL	TF	RBM8A	POGK	0.819627636	5.78E-12
CHOL	TF	RBM8A	ZNF687	0.84321411	3.65E-13
CHOL	TSG	RBM8A	GORAB	0.800308772	4.19E-11
DLBC	Cell metabolism gene	RBM8A	LSM3	0.80094453	8.18E-12
DLBC	Cell metabolism gene	RBM8A	SNRPE	0.800989001	8.14E-12
DLBC	Cell metabolism gene	RBM8A	PSMB7	0.803068999	6.55E-12
DLBC	Cell metabolism gene	RBM8A	PSMB3	0.80659306	4.50E-12
DLBC	Cell metabolism gene	RBM8A	TIMM50	0.813211044	2.18E-12
DLBC	Cell metabolism gene	RBM8A	SNRPD2	0.846978684	3.27E-14
DLBC	Epifactor	RBM8A	RUVBL2	0.831840728	2.41E-13
DLBC	IUPHAR	RBM8A	BIRC5	0.80102962	8.10E-12
DLBC	TSG	RBM8A	GADD45GIP1	0.809903959	3.14E-12
DLBC	TSG	RBM8A	PHB	0.814411512	1.91E-12
KICH	Cell metabolism gene	RBM8A	CDK19	0.801214609	1.48E-21
KICH	Cell metabolism gene	RBM8A	GYG2	0.811387895	1.81E-22
KICH	Cell metabolism gene	RBM8A	FPGT	0.817081061	5.30E-23
KICH	Cell metabolism gene	RBM8A	SSR1	0.828011837	4.40E-24
KICH	Cell metabolism gene	RBM8A	BPNT1	0.835695404	6.88E-25
KICH	CGC	RBM8A	SMARCE1	0.800347646	1.76E-21
KICH	CGC	RBM8A	CDC73	0.819117957	3.38E-23
KICH	Epifactor	RBM8A	SMARCE1	0.800347646	1.76E-21
KICH	Epifactor	RBM8A	CDC73	0.819117957	3.38E-23
KICH	Epifactor	RBM8A	RNF2	0.826241478	6.66E-24
KICH	Epifactor	RBM8A	HAT1	0.830517547	2.43E-24
KICH	Epifactor	RBM8A	ANP32E	0.848916117	2.23E-26
KICH	IUPHAR	RBM8A	CDK19	0.801214609	1.48E-21
KICH	IUPHAR	RBM8A	LEPR	0.815693158	7.18E-23
KICH	IUPHAR	RBM8A	NEK11	0.816363983	6.20E-23
KICH	IUPHAR	RBM8A	HAT1	0.830517547	2.43E-24
KICH	Kinase	RBM8A	CDK19	0.801214609	1.48E-21
KICH	Kinase	RBM8A	NEK11	0.816363983	6.20E-23
KICH	TF	RBM8A	DZIP1	0.821113083	2.16E-23
KICH	TSG	RBM8A	IFT88	0.804710059	7.30E-22
KICH	TSG	RBM8A	CDC73	0.819117957	3.38E-23
THYM	Cell metabolism gene	RBM8A	CCT3	0.814660856	3.58E-30
UCS	Cell metabolism gene	RBM8A	CCT3	0.814660856	3.58E-30

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	RBM8A	UPF1	-1.33899089151335	0.000117696606626909
KIRP	RBM8A	UPF2	1.10034051816662	0.00016188295558095
KICH	RBM8A	UPF2	1.81701753444023	0.000187873840332031
HNSC	RBM8A	WIBG	-3.52931483831729	0.000193349219898665
LIHC	RBM8A	EIF4A3	-1.04153136776482	0.000244220248656818
KICH	RBM8A	MAGOH	1.31213226036903	0.000489473342895508
KICH	RBM8A	MAGOHB	-2.78720320822119	0.000631332397460937
ESCA	RBM8A	MAGOH	-1.05171733593575	0.001953125
STAD	RBM8A	MAGOH	-7.08664861839682	0.00239070039242506
ESCA	RBM8A	EIF4A3	-2.29521324800567	0.0029296875
ESCA	RBM8A	MAGOHB	-1.4704793258487	0.0029296875
CHOL	RBM8A	CASC3	-3.17436454829931	0.00390625
CHOL	RBM8A	NCBP2	-4.92698915177883	0.00390625
LIHC	RBM8A	UPF1	-1.92491321082533	0.00427166918402987
STAD	RBM8A	EIF4A3	-1.12631690036833	0.00471024587750435
CHOL	RBM8A	EIF4A3	-1.38498420757674	0.0078125
LUSC	RBM8A	WIBG	-3.20337112636119	0.0095481412838183
ESCA	RBM8A	NCBP2	-1.45527935513217	0.009765625
KIRP	RBM8A	EIF4A3	-1.24117912616368	0.0132303284481168
KICH	RBM8A	SMG7	-3.12704951191874	0.0147220492362976
UCEC	RBM8A	MAGOH	1.27687101625693	0.015625
UCEC	RBM8A	UPF3B	2.6168012623237	0.015625
BLCA	RBM8A	EIF4A3	2.06229583387624	0.0229873657226562
KIRC	RBM8A	SMG7	-1.1094519769225	0.0288335630234894
THCA	RBM8A	CASC3	-1.98552260124303	1.06153421192981e-05
LUAD	RBM8A	EIF4A3	-6.29327680237469	1.10446534121172e-08
KICH	RBM8A	CASC3	2.460446087114	1.13248825073242e-06
LIHC	RBM8A	SMG7	-3.30076827554849	1.16024886167082e-07
LUAD	RBM8A	NCBP2	-1.46041890027754	2.13281101437522e-07
BRCA	RBM8A	WIBG	-2.57980080203157	2.14379105410843e-16
BRCA	RBM8A	CASC3	-1.16162187143676	2.40691120397045e-08
KIRP	RBM8A	WIBG	-1.09150515457177	2.84211710095406e-05
LUAD	RBM8A	UPF3B	-1.59170310090777	3.00449244753167e-05
HNSC	RBM8A	MAGOHB	-2.58797748897339	3.60935187018186e-05
PRAD	RBM8A	SMG7	-1.29937173988877	3.64137470248972e-06
PRAD	RBM8A	UPF1	1.18312136515194	3.77428293642232e-05
LUAD	RBM8A	SMG7	-4.86005916031842	4.03473265936455e-08
KICH	RBM8A	EIF4A3	2.80243879140225	5.96046447753906e-08
LIHC	RBM8A	CASC3	-1.20911462053045	6.19992789528317e-09
BRCA	RBM8A	MAGOH	-1.0184441150683	6.3167513638082e-06
KIRC	RBM8A	MAGOHB	-1.1887059409553	6.64395189280361e-09
LIHC	RBM8A	UPF3B	-1.61501915266319	6.95667288468821e-09
LUAD	RBM8A	MAGOHB	-4.63048308295843	9.18150694907422e-08

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RBM8A

MAGOH, MCM7, MAGOHB, IPO13, RNPS1, NXF1, UPF3A, ALYREF, DPH1, USP21, RAE1, IKBKG, SRRM1, SRRM2, tat, EIF4A3, APP, HNRNPM, DHX38, RBMX, SNRPF, DHX9, LSM2, DDX39B, SLU7, RPSA, PSMB1, SLIRP, CIAPIN1, SPTBN1, TFCP2L1, RBM14, UNC119B, RAD23B, SEPHS2, UPF1, SMG1, SMG8, SMG9, UPF2, GSPT1, ZFP36L1, RPL11, RPS16, HBB, SF3B2, TOE1, NCBP2, PABPC1, UPF3B, SMG7, RBM8A, RUVBL1, RUVBL2, TTI1, SMG5, FBXO25, SRPK2, SRPK1, PARK2, KAT2B, SMG6, R3HCC1L, TDRD3, OBSL1, SUZ12, RNF2, LUZP4, CLTA, EHBP1L1, LSM3, LUC7L2, MLEC, NCAPH2, PDAP1, PUS7, RRBP1, SLK, WIBG, IFI16, EWSR1, RPGRIP1, CTSC, ORC2, P4HA1, P4HB, PGD, UTRN, RNF113A, CDC42BPA, C2CD5, HNRNPD, BCAP31, PKP3, CASC3, ZMYND8, CCDC9, APTX, P3H1, THOC7, TMEM263, NOP9, SDE2, NCBP2-AS2, Magoh, RBM3, DLST, DNM1L, PDHA1, SOD1, TRIM14, GSK3A, KRAS, UBE2M, EFTUD2, TNIP2, ESR2, AGR2, RECQL4, VCP, MYC, PHB, NR2C2, HIST1H4A, SNRNP70, NFX1, TCF12, RAD18, FANCD2, ZC3H18, SNIP1, ESR1, CHMP4C, ECT2, KIF14, PRC1, C17orf80, CHCHD1, MTX2, CDC42, NUPR1, NPC1, BRD4, COPS5, RBM39, NR3C1, NEDD4, FKBP3, PARK7, PEBP1, PGAM1, STMN1, PTMS, PRKCSH, PDIA4, TKT, SUMO2, MARCKS, BASP1, CALM1, ANP32A, EIF6, TPM3, PPIB, NACA, HMGA1, UFL1, DDRGK1, ZBTB2, DOC2B,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RBM8A	chr1	145507253	A	G	single_nucleotide_variant	Benign	not_provided
RBM8A	chr1	145507646	G	A	single_nucleotide_variant	Pathogenic/Likely_pathogenic,_other	Radial_aplasia-thrombocytopenia_syndrome\|not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
RBM8A	chr1	145507648	G	T	single_nucleotide_variant	Pathogenic	Radial_aplasia-thrombocytopenia_syndrome	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
RBM8A	chr1	145507765	G	C	single_nucleotide_variant	Pathogenic/Likely_pathogenic	Global_developmental_delay\|Clinodactyly_of_the_5th_finger\|Abnormality_of_brain_morphology\|Radial_aplasia-thrombocytopenia_syndrome\|not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
RBM8A	chr1	145507787	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
RBM8A	chr1	145507826	A	T	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
RBM8A	chr1	145508010	T	C	single_nucleotide_variant	Benign/Likely_benign	Radial_aplasia-thrombocytopenia_syndrome\|not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
RBM8A	chr1	145508012	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
RBM8A	chr1	145508013	C	T	single_nucleotide_variant	Uncertain_significance	Radial_aplasia-thrombocytopenia_syndrome	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
RBM8A	chr1	145508146	C	A	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RBM8A	chr1	145508198	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
RBM8A	chr1	145508284	TGTGA	T	Deletion	Pathogenic	Radial_aplasia-thrombocytopenia_syndrome	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RBM8A	chr1	145508301	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RBM8A	chr1	145508455	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RBM8A	chr1	145508462	C	A	single_nucleotide_variant	Pathogenic	Radial_aplasia-thrombocytopenia_syndrome	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RBM8A	chr1	145508476	T	TAGCG	Insertion	Pathogenic	Radial_aplasia-thrombocytopenia_syndrome	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RBM8A	chr1	145508509	C	T	single_nucleotide_variant	Benign/Likely_benign	Radial_aplasia-thrombocytopenia_syndrome\|not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RBM8A	chr1	145508534	A	G	single_nucleotide_variant	Likely_benign	Radial_aplasia-thrombocytopenia_syndrome\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RBM8A	chr1	145508587	C	T	single_nucleotide_variant	Benign/Likely_benign	Radial_aplasia-thrombocytopenia_syndrome\|not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RBM8A	chr1	145508604	ATCTGAAGGT	A	Deletion	Likely_pathogenic	Radial_aplasia-thrombocytopenia_syndrome	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RBM8A	chr1	145508914	A	G	single_nucleotide_variant	Pathogenic	Radial_aplasia-thrombocytopenia_syndrome	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
RBM8A	chr1	145509067	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RBM8A	chr1	145509173	C	T	single_nucleotide_variant	Pathogenic	Radial_aplasia-thrombocytopenia_syndrome	SO:0001587\|nonsense	SO:0001587\|nonsense
RBM8A	chr1	145509217	C	G	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
RBM8A	chr1	145509319	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RBM8A	BRCA	chr1	145507682	145507682	G	A	Missense_Mutation	p.D6N	3
RBM8A	BRCA	chr1	145508273	145508273	G	T	Missense_Mutation	p.G65V	3
RBM8A	LIHC	chr1	145508915	145508915	G	-	Splice_Site		3
RBM8A	STAD	chr1	145509207	145509207	G	A	Missense_Mutation	p.R174H	3
RBM8A	PAAD	chr1	145508545	145508545	A	C	Missense_Mutation	p.K92N	3
RBM8A	BLCA	chr1	145508209	145508209	G	C	Missense_Mutation	p.E44Q	2
RBM8A	LIHC	chr1	145508934	145508934	T	C	Missense_Mutation		2
RBM8A	BLCA	chr1	145508206	145508206	G	C	Splice_Site		2
RBM8A	LIHC	chr1	145508934	145508934	T	C	Missense_Mutation	p.Y121H	2
RBM8A	LUAD	chr1	145507688	145507688	C	T	Missense_Mutation	p.H8Y	2
RBM8A	ESCA	chr1	145508235	145508235	G	T	Missense_Mutation	p.E52D	2
RBM8A	THYM	chr1	145509002	145509002	C	A	Silent		2
RBM8A	BLCA	chr1	145507706	145507706	G	C	Missense_Mutation		2
RBM8A	THYM	chr1	145509002	145509002	C	A	Silent	p.P143P	2
RBM8A	PAAD	chr1	145508545	145508545	A	C	Missense_Mutation		2
RBM8A	KIRC	chr1	145508564	145508564	A	C	Missense_Mutation	p.I99L	2
RBM8A	UCEC	chr1	145509027	145509027	C	T	Missense_Mutation	p.R152W	2
RBM8A	BLCA	chr1	145508209	145508209	G	C	Splice_Site		2
RBM8A	BLCA	chr1	145507721	145507721	G	A	Missense_Mutation	p.E19K	2
RBM8A	KIRP	chr1	145507671	145507671	C	T	Missense_Mutation	p.A2V	1
RBM8A	BLCA	chr1	145508540	145508540	G	A	Missense_Mutation		1
RBM8A	READ	chr1	145509017	145509017	G	C	Missense_Mutation	p.W148C	1
RBM8A	SARC	chr1	145509007	145509007	G	T	Missense_Mutation		1
RBM8A	BLCA	chr1	145508608	145508608	G	A	Silent	p.L113L	1
RBM8A	SKCM	chr1	145507696	145507696	T	A	Silent	p.A10A	1
RBM8A	BLCA	chr1	145509201	145509201	G	C	Missense_Mutation	p.R172T	1
RBM8A	SKCM	chr1	145507711	145507711	C	T	Silent	p.F15F	1
RBM8A	CESC	chr1	145508044	145508044	G	G	Silent		1
RBM8A	BLCA	chr1	145508513	145508513	G	C	Missense_Mutation		1
RBM8A	BLCA	chr1	145508513	145508513	G	C	Missense_Mutation	p.E82Q	1
RBM8A	BLCA	chr1	145508608	145508608	G	A	Silent		1
RBM8A	LUAD	chr1	145507705	145507705	A	T	Missense_Mutation	p.E13D	1
RBM8A	BLCA	chr1	145507706	145507706	G	C	Missense_Mutation	p.D14H	1
RBM8A	TGCT	chr1	145508587	145508587	C	T	Silent		1
RBM8A	ESCA	chr1	145508235	145508235	G	T	Missense_Mutation		1
RBM8A	BLCA	chr1	145509201	145509201	G	C	Missense_Mutation		1
RBM8A	LUSC	chr1	145509204	145509204	G	T	Missense_Mutation	p.R173L	1
RBM8A	BLCA	chr1	145507691	145507691	G	A	Missense_Mutation	p.E9K	1
RBM8A	HNSC	chr1	145508277	145508277	A	T	Silent		1
RBM8A	LUSC	chr1	145508257	145508257	G	C	Missense_Mutation	p.D60H	1
RBM8A	BLCA	chr1	145509174	145509174	G	A	Missense_Mutation	p.R163Q	1
RBM8A	HNSC	chr1	145508277	145508277	A	T	Silent	p.P66P	1
RBM8A	BLCA	chr1	145509174	145509174	G	A	Missense_Mutation		1
RBM8A	BLCA	chr1	145507706	145507706	G	T	Missense_Mutation	p.D14Y	1
RBM8A	THYM	chr1	145509002	145509002	C	A	Silent	p.P143	1
RBM8A	BLCA	chr1	145507721	145507721	G	A	Missense_Mutation		1
RBM8A	PAAD	chr1	145509027	145509027	C	A	Silent		1
RBM8A	BLCA	chr1	145508540	145508540	G	A	Missense_Mutation	p.D91N	1
RBM8A	KIRC	chr1	145509177	145509177	G	T	Missense_Mutation	p.R164I	1

Copy number variation (CNV) of RBM8A
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RBM8A
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
101909	N/A	CR736380	RBM8A	chr1	145510258	-	DYNLRB1	chr20	33114114	+
73007	N/A	DN912033	RBM8A	chr1	145509370	-	ENPP7P8	chr11	71443972	+
100478	BRCA	TCGA-BH-A203-01A	RBM8A	chr1	145509230	-	FCAMR	chr1	207133142	-
85264	N/A	DA211154	RBM8A	chr1	145508074	-	SOS1	chr2	39213173	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	RBM8A	0.000336615250648342	0.0094
THCA	RBM8A	0.00549299007702578	0.15
TGCT	RBM8A	0.0250382287457807	0.65
STAD	RBM8A	0.0310892868185939	0.78
KIRC	RBM8A	0.0423347267390727	1
SARC	RBM8A	0.0423935797821255	1
READ	RBM8A	0.0477746055417045	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	RBM8A	0.0105785043418957	0.34
KICH	RBM8A	0.0327433615229572	0.95
BRCA	RBM8A	0.0010037927700567	0.033
UCEC	RBM8A	0.0194937866716083	0.6
ESCA	RBM8A	0.0262167854736384	0.79

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0175703	Thrombocytopenia-Absent Radius Syndrome	3	CTD_human;GENOMICS_ENGLAND;ORPHANET
C3554656	DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 5	1	GENOMICS_ENGLAND
C4225346	PULMONARY FIBROSIS AND/OR BONE MARROW FAILURE, TELOMERE-RELATED, 3	1	GENOMICS_ENGLAND