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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HUWE1-BICD1 (FusionGDB2 ID:HG10075TG636)

Fusion Gene Summary for HUWE1-BICD1

check button Fusion gene summary
Fusion gene informationFusion gene name: HUWE1-BICD1
Fusion gene ID: hg10075tg636
HgeneTgene
Gene symbol

HUWE1

BICD1

Gene ID

10075

636

Gene nameHECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1BICD cargo adaptor 1
SynonymsARF-BP1|HECTH9|HSPC272|Ib772|LASU1|MRXST|MULE|URE-B1|UREB1BICD|bic-D 1
Cytomap('HUWE1')('BICD1')

Xp11.22

12p11.21

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase HUWE1ARF-binding protein 1BJ-HCC-24 tumor antigenHECT domain protein LASU1HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligaseHECT-type E3 ubiquitin transferase HUWE1Mcl-1 ubiquitin ligase E3URE-binding proprotein bicaudal D homolog 1bicaudal D homolog 1cytoskeleton-like bicaudal D protein homolog 1
Modification date2020031320200313
UniProtAcc.

Q96G01

Ensembl transtripts involved in fusion geneENST00000218328, ENST00000262854, 
ENST00000342160, ENST00000474288, 
Fusion gene scores* DoF score17 X 22 X 7=261813 X 12 X 6=936
# samples 2214
** MAII scorelog2(22/2618*10)=-3.57288966842058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/936*10)=-2.74108170263844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HUWE1 [Title/Abstract] AND BICD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHUWE1(53651556)-BICD1(32520604), # samples:2
Anticipated loss of major functional domain due to fusion event.HUWE1-BICD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HUWE1-BICD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HUWE1-BICD1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
HUWE1-BICD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHUWE1

GO:0000209

protein polyubiquitination

15989957

HgeneHUWE1

GO:0006513

protein monoubiquitination

19713937

HgeneHUWE1

GO:0016574

histone ubiquitination

15767685

HgeneHUWE1

GO:0031398

positive regulation of protein ubiquitination

20534529

HgeneHUWE1

GO:0098779

positive regulation of mitophagy in response to mitochondrial depolarization

30217973

TgeneBICD1

GO:0033365

protein localization to organelle

12447383|20089649


check buttonFusion gene breakpoints across HUWE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across BICD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-XF-A9SM-01AHUWE1chrX

53651556

-BICD1chr12

32520604

+


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Fusion Gene ORF analysis for HUWE1-BICD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000218328ENST00000550207HUWE1chrX

53651556

-BICD1chr12

32520604

+
5CDS-intronENST00000218328ENST00000551086HUWE1chrX

53651556

-BICD1chr12

32520604

+
5CDS-intronENST00000218328ENST00000551848HUWE1chrX

53651556

-BICD1chr12

32520604

+
5CDS-intronENST00000262854ENST00000550207HUWE1chrX

53651556

-BICD1chr12

32520604

+
5CDS-intronENST00000262854ENST00000551086HUWE1chrX

53651556

-BICD1chr12

32520604

+
5CDS-intronENST00000262854ENST00000551848HUWE1chrX

53651556

-BICD1chr12

32520604

+
5CDS-intronENST00000342160ENST00000550207HUWE1chrX

53651556

-BICD1chr12

32520604

+
5CDS-intronENST00000342160ENST00000551086HUWE1chrX

53651556

-BICD1chr12

32520604

+
5CDS-intronENST00000342160ENST00000551848HUWE1chrX

53651556

-BICD1chr12

32520604

+
Frame-shiftENST00000218328ENST00000548411HUWE1chrX

53651556

-BICD1chr12

32520604

+
Frame-shiftENST00000262854ENST00000548411HUWE1chrX

53651556

-BICD1chr12

32520604

+
Frame-shiftENST00000342160ENST00000281474HUWE1chrX

53651556

-BICD1chr12

32520604

+
Frame-shiftENST00000342160ENST00000548411HUWE1chrX

53651556

-BICD1chr12

32520604

+
In-frameENST00000218328ENST00000281474HUWE1chrX

53651556

-BICD1chr12

32520604

+
In-frameENST00000262854ENST00000281474HUWE1chrX

53651556

-BICD1chr12

32520604

+
intron-3CDSENST00000474288ENST00000281474HUWE1chrX

53651556

-BICD1chr12

32520604

+
intron-3CDSENST00000474288ENST00000548411HUWE1chrX

53651556

-BICD1chr12

32520604

+
intron-intronENST00000474288ENST00000550207HUWE1chrX

53651556

-BICD1chr12

32520604

+
intron-intronENST00000474288ENST00000551086HUWE1chrX

53651556

-BICD1chr12

32520604

+
intron-intronENST00000474288ENST00000551848HUWE1chrX

53651556

-BICD1chr12

32520604

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262854HUWE1chrX53651556-ENST00000281474BICD1chr1232520604+248820743872237616
ENST00000218328HUWE1chrX53651556-ENST00000281474BICD1chr1232520604+248820743872237616

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262854ENST00000281474HUWE1chrX53651556-BICD1chr1232520604+0.0075560850.99244386
ENST00000218328ENST00000281474HUWE1chrX53651556-BICD1chr1232520604+0.0075560850.99244386

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Fusion Genomic Features for HUWE1-BICD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HUWE1chrX53651555-BICD1chr1232520603+1.25E-060.9999988
HUWE1chrX53651555-BICD1chr1232520603+1.25E-060.9999988

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HUWE1-BICD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:53651556/chr12:32520604)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BICD1

Q96G01

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBICD1chrX:53651556chr12:32520604ENST00000551848011_265094.0Coiled coilOntology_term=ECO:0000255
TgeneBICD1chrX:53651556chr12:32520604ENST0000055184801319_496094.0Coiled coilOntology_term=ECO:0000255
TgeneBICD1chrX:53651556chr12:32520604ENST0000055184801663_803094.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHUWE1chrX:53651556chr12:32520604ENST00000262854-19842295_24695574375.0Compositional biasNote=Glu-rich
HgeneHUWE1chrX:53651556chr12:32520604ENST00000262854-19842427_24905574375.0Compositional biasNote=Asp-rich
HgeneHUWE1chrX:53651556chr12:32520604ENST00000262854-19843483_35505574375.0Compositional biasNote=Thr-rich
HgeneHUWE1chrX:53651556chr12:32520604ENST00000342160-18832295_24695574375.0Compositional biasNote=Glu-rich
HgeneHUWE1chrX:53651556chr12:32520604ENST00000342160-18832427_24905574375.0Compositional biasNote=Asp-rich
HgeneHUWE1chrX:53651556chr12:32520604ENST00000342160-18833483_35505574375.0Compositional biasNote=Thr-rich
HgeneHUWE1chrX:53651556chr12:32520604ENST00000262854-19841316_13555574375.0DomainUBA
HgeneHUWE1chrX:53651556chr12:32520604ENST00000262854-19841370_13895574375.0DomainUIM
HgeneHUWE1chrX:53651556chr12:32520604ENST00000262854-19841603_16805574375.0DomainWWE
HgeneHUWE1chrX:53651556chr12:32520604ENST00000262854-19844038_43745574375.0DomainHECT
HgeneHUWE1chrX:53651556chr12:32520604ENST00000342160-18831316_13555574375.0DomainUBA
HgeneHUWE1chrX:53651556chr12:32520604ENST00000342160-18831370_13895574375.0DomainUIM
HgeneHUWE1chrX:53651556chr12:32520604ENST00000342160-18831603_16805574375.0DomainWWE
HgeneHUWE1chrX:53651556chr12:32520604ENST00000342160-18834038_43745574375.0DomainHECT
TgeneBICD1chrX:53651556chr12:32520604ENST000002814747101_265921976.0Coiled coilOntology_term=ECO:0000255
TgeneBICD1chrX:53651556chr12:32520604ENST00000281474710319_496921976.0Coiled coilOntology_term=ECO:0000255
TgeneBICD1chrX:53651556chr12:32520604ENST00000281474710663_803921976.0Coiled coilOntology_term=ECO:0000255
TgeneBICD1chrX:53651556chr12:32520604ENST00000548411691_2658202736.0Coiled coilOntology_term=ECO:0000255
TgeneBICD1chrX:53651556chr12:32520604ENST0000054841169319_4968202736.0Coiled coilOntology_term=ECO:0000255
TgeneBICD1chrX:53651556chr12:32520604ENST0000054841169663_8038202736.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for HUWE1-BICD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>38105_38105_1_HUWE1-BICD1_HUWE1_chrX_53651556_ENST00000218328_BICD1_chr12_32520604_ENST00000281474_length(transcript)=2488nt_BP=2074nt
GAGGCTTTCGACTGAGGGCTAGCGAGGGGAGCACGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGAAGCAGG
GCCGCGGACCCCGCACGCTCCTGCGGGCCCCGCGGAGCCATTGCGGCCGAGGCCTCGGCAGGCGCCAGCGGAGAGCTAGCCGCATCTTCG
GGGGCAGCCCGGCAGCTGCCGGCGGCGCGGCGAGAGAGCGGCTGACAGAGGGGATGCGAGGTCCTCCAGCAGCCTGACCTGAGTGGGTTA
GTGATCCAGAGAAACCAGCAGGCCAACTTGGTCAGGAAGGTTCGGGAAGCTGTTGGAGCAGTGTGGGGAATTTCCCACCAGGATGAGTAT
GATTGGCTGTGATTTTAGATCGTAAAGCTGAAAATTGAAATCATGAAAGTAGACAGGACTAAACTGAAGAAGACACCTACTGAGGCTCCT
GCAGACTGCAGAGCCTTAATAGACAAACTCAAAGTTTGTAATGATGAGCAACTTCTCTTGGAACTGCAGCAGATCAAAACATGGAACATT
GGAAAGTGCGAGTTATATCACTGGGTGGACCTGTTGGACCGCTTCGATGGAATACTGGCAGATGCTGGACAGACAGTGGAGAATATGTCA
TGGATGCTCGTATGTGATAGGCCAGAAAGAGAGCAACTGAAAATGCTTCTCTTGGCTGTGTTGAACTTCACAGCCTTGCTCATTGAGTAC
AGCTTTTCCCGGCATCTGTACAGTTCCATAGAGCATTTGACAACTTTATTGGCTTCCTCTGATATGCAAGTGGTGCTGGCAGTCCTCAAT
CTCCTATATGTATTTAGCAAAAGATCAAACTACATCACTCGTCTGGGATCTGACAAGAGGACCCCGCTGCTAACTCGGCTACAACATTTG
GCAGAGAGCTGGGGTGGAAAGGAGAATGGCTTTGGACTTGCAGAATGTTGCAGAGACTTGCATATGATGAAATATCCACCCAGTGCAACT
ACACTACACTTTGAATTCTATGCAGATCCTGGGGCCGAGGTCAAAATTGAGAAAAGGACAACTAGTAACACACTACATTATATTCACATA
GAGCAACTTGACAAGATTTCAGAAAGCCCTTCTGAAATCATGGAATCTCTTACCAAAATGTACAGCATTCCTAAGGATAAGCAGATGCTG
TTATTTACACACATACGACTGGCCCATGGCTTTTCTAATCACAGGAAGCGATTGCAGGCAGTTCAGGCCAGACTGCATGCAATATCTATA
TTAGTGTATTCCAATGCCTTGCAGGAATCAGCAAACAGTATCTTGTATAATGGCTTGATAGAGGAGTTGGTAGATGTCCTTCAGATAACG
GATAAGCAGCTTATGGAGATTAAAGCAGCTTCTTTACGAACATTAACATCAATTGTCCACTTGGAGAGAACTCCCAAACTCAGCAGTATT
ATTGACTGTACTGGAACTGCCTCCTACCATGGATTTTTGCCAGTGCTTGTAAGGAACTGTATCCAGGCCATGATTGATCCTTCCATGGAT
CCATACCCTCACCAGTTTGCCACTGCTCTCTTCTCTTTTTTATACCATCTGGCCAGCTACGATGCTGGTGGTGAAGCCTTGGTCTCCTGT
GGAATGATGGAAGCCTTATTGAAGGTCATAAAGTTTCTTGGCGATGAACAGGACCAGATAACATTTGTCACCAGAGCCGTCAGAGTGGTT
GACCTTATCACCAACCTGGATATGGCAGCTTTTCAATCCCATAGTGGACTTTCTATCTTCATTTATAGACTTGAGCATGAAGTAGATTTG
TGCCGAAAAGAATGTCCGTTTGTGATCAAGCCAAAGATCCAGAGACCCAATACTACACAAGAAGGAGAGGAAATGGAAACTGATATGGAT
GGAGTCCAGTGTATTCCACAACGAGCAGCACTTCTGAAATCCATGTTGAATTTCCTCAAGAAGGCCATCCAAGACCCTGCTTTCTCAGAT
GGCATACGACATGTGATGGATGGTTCTCTGCCTACCTCCCTGAAACACATCATCAGCAATGCAGAATACTATGGCCCATCACTCTTCCTC
CTAGATTGTCAGCAGCCTGCTGCCTCCGTACCGCCACAGTGCTCACAACTAGCCGGGAGGCAAGACTGCCCAACTGTCAGTCCTGACACA
GCTCTCCCTGAGGAGCAGCCACATTCCAGCTCCCAGTGCGCCCCTCTCCACTGTCTCTCCAAGCCTCCTCACCCCTAGTCTTCATCTCCT
GTGGACGAACATCTGGGGTGGAAGTTTTGTAGCCACACACAGGATACTGCCCAAGATCCAGCGGGTGTTTTCTTCTCGGTTGTTAGATGT
ACAATTGGATTAATGTCCATCGTTTTGGAAGACGAGAGAAAGTTGAGAAGAACACGAAGCACAGACCCTGATGTGATAAAACATTTTGTG

>38105_38105_1_HUWE1-BICD1_HUWE1_chrX_53651556_ENST00000218328_BICD1_chr12_32520604_ENST00000281474_length(amino acids)=616AA_BP=559
MKIEIMKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRFDGILADAGQTVENMSWMLVCDRPE
REQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKEN
GFGLAECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAH
GFSNHRKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASY
HGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMA
AFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQRPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGS

--------------------------------------------------------------
>38105_38105_2_HUWE1-BICD1_HUWE1_chrX_53651556_ENST00000262854_BICD1_chr12_32520604_ENST00000281474_length(transcript)=2488nt_BP=2074nt
GAGGCTTTCGACTGAGGGCTAGCGAGGGGAGCACGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGAAGCAGG
GCCGCGGACCCCGCACGCTCCTGCGGGCCCCGCGGAGCCATTGCGGCCGAGGCCTCGGCAGGCGCCAGCGGAGAGCTAGCCGCATCTTCG
GGGGCAGCCCGGCAGCTGCCGGCGGCGCGGCGAGAGAGCGGCTGACAGAGGGGATGCGAGGTCCTCCAGCAGCCTGACCTGAGTGGGTTA
GTGATCCAGAGAAACCAGCAGGCCAACTTGGTCAGGAAGGTTCGGGAAGCTGTTGGAGCAGTGTGGGGAATTTCCCACCAGGATGAGTAT
GATTGGCTGTGATTTTAGATCGTAAAGCTGAAAATTGAAATCATGAAAGTAGACAGGACTAAACTGAAGAAGACACCTACTGAGGCTCCT
GCAGACTGCAGAGCCTTAATAGACAAACTCAAAGTTTGTAATGATGAGCAACTTCTCTTGGAACTGCAGCAGATCAAAACATGGAACATT
GGAAAGTGCGAGTTATATCACTGGGTGGACCTGTTGGACCGCTTCGATGGAATACTGGCAGATGCTGGACAGACAGTGGAGAATATGTCA
TGGATGCTCGTATGTGATAGGCCAGAAAGAGAGCAACTGAAAATGCTTCTCTTGGCTGTGTTGAACTTCACAGCCTTGCTCATTGAGTAC
AGCTTTTCCCGGCATCTGTACAGTTCCATAGAGCATTTGACAACTTTATTGGCTTCCTCTGATATGCAAGTGGTGCTGGCAGTCCTCAAT
CTCCTATATGTATTTAGCAAAAGATCAAACTACATCACTCGTCTGGGATCTGACAAGAGGACCCCGCTGCTAACTCGGCTACAACATTTG
GCAGAGAGCTGGGGTGGAAAGGAGAATGGCTTTGGACTTGCAGAATGTTGCAGAGACTTGCATATGATGAAATATCCACCCAGTGCAACT
ACACTACACTTTGAATTCTATGCAGATCCTGGGGCCGAGGTCAAAATTGAGAAAAGGACAACTAGTAACACACTACATTATATTCACATA
GAGCAACTTGACAAGATTTCAGAAAGCCCTTCTGAAATCATGGAATCTCTTACCAAAATGTACAGCATTCCTAAGGATAAGCAGATGCTG
TTATTTACACACATACGACTGGCCCATGGCTTTTCTAATCACAGGAAGCGATTGCAGGCAGTTCAGGCCAGACTGCATGCAATATCTATA
TTAGTGTATTCCAATGCCTTGCAGGAATCAGCAAACAGTATCTTGTATAATGGCTTGATAGAGGAGTTGGTAGATGTCCTTCAGATAACG
GATAAGCAGCTTATGGAGATTAAAGCAGCTTCTTTACGAACATTAACATCAATTGTCCACTTGGAGAGAACTCCCAAACTCAGCAGTATT
ATTGACTGTACTGGAACTGCCTCCTACCATGGATTTTTGCCAGTGCTTGTAAGGAACTGTATCCAGGCCATGATTGATCCTTCCATGGAT
CCATACCCTCACCAGTTTGCCACTGCTCTCTTCTCTTTTTTATACCATCTGGCCAGCTACGATGCTGGTGGTGAAGCCTTGGTCTCCTGT
GGAATGATGGAAGCCTTATTGAAGGTCATAAAGTTTCTTGGCGATGAACAGGACCAGATAACATTTGTCACCAGAGCCGTCAGAGTGGTT
GACCTTATCACCAACCTGGATATGGCAGCTTTTCAATCCCATAGTGGACTTTCTATCTTCATTTATAGACTTGAGCATGAAGTAGATTTG
TGCCGAAAAGAATGTCCGTTTGTGATCAAGCCAAAGATCCAGAGACCCAATACTACACAAGAAGGAGAGGAAATGGAAACTGATATGGAT
GGAGTCCAGTGTATTCCACAACGAGCAGCACTTCTGAAATCCATGTTGAATTTCCTCAAGAAGGCCATCCAAGACCCTGCTTTCTCAGAT
GGCATACGACATGTGATGGATGGTTCTCTGCCTACCTCCCTGAAACACATCATCAGCAATGCAGAATACTATGGCCCATCACTCTTCCTC
CTAGATTGTCAGCAGCCTGCTGCCTCCGTACCGCCACAGTGCTCACAACTAGCCGGGAGGCAAGACTGCCCAACTGTCAGTCCTGACACA
GCTCTCCCTGAGGAGCAGCCACATTCCAGCTCCCAGTGCGCCCCTCTCCACTGTCTCTCCAAGCCTCCTCACCCCTAGTCTTCATCTCCT
GTGGACGAACATCTGGGGTGGAAGTTTTGTAGCCACACACAGGATACTGCCCAAGATCCAGCGGGTGTTTTCTTCTCGGTTGTTAGATGT
ACAATTGGATTAATGTCCATCGTTTTGGAAGACGAGAGAAAGTTGAGAAGAACACGAAGCACAGACCCTGATGTGATAAAACATTTTGTG

>38105_38105_2_HUWE1-BICD1_HUWE1_chrX_53651556_ENST00000262854_BICD1_chr12_32520604_ENST00000281474_length(amino acids)=616AA_BP=559
MKIEIMKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRFDGILADAGQTVENMSWMLVCDRPE
REQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKEN
GFGLAECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAH
GFSNHRKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASY
HGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMA
AFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQRPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGS

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Fusion Gene PPI Analysis for HUWE1-BICD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HUWE1-BICD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HUWE1-BICD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHUWE1C3501611Mental Retardation, X-Linked Nonsyndromic15CLINGEN
HgeneHUWE1C2678046Mental Retardation, X-Linked, Syndromic, Turner Type1CTD_human;GENOMICS_ENGLAND;ORPHANET