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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ATP6AP2-EIF3M (FusionGDB2 ID:HG10159TG10480) |
Fusion Gene Summary for ATP6AP2-EIF3M |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATP6AP2-EIF3M | Fusion gene ID: hg10159tg10480 | Hgene | Tgene | Gene symbol | ATP6AP2 | EIF3M | Gene ID | 10159 | 10480 |
| Gene name | ATPase H+ transporting accessory protein 2 | eukaryotic translation initiation factor 3 subunit M | |
| Synonyms | APT6M8-9|ATP6IP2|ATP6M8-9|ELDF10|HT028|M8-9|MRXE|MRXSH|MSTP009|PRR|RENR|XMRE|XPDS | B5|GA17|PCID1|TANGO7|hfl-B5 | |
| Cytomap | ('ATP6AP2')('EIF3M') Xp11.4 | 11p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | renin receptorATPase H(+)-transporting lysosomal-interacting protein 2ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8-9ATPase, H+ transporting, lysosomal accessory protein 2ATPase, H+ transporting, lysos | eukaryotic translation initiation factor 3 subunit MB5 receptorPCI domain containing 1 (herpesvirus entry mediator)PCI domain-containing protein 1dendritic cell proteinfetal lung protein B5transport and golgi organization 7 homolog | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000378438, ENST00000486558, ENST00000535539, ENST00000535777, ENST00000544975, | ||
| Fusion gene scores | * DoF score | 5 X 4 X 2=40 | 10 X 7 X 6=420 |
| # samples | 5 | 11 | |
| ** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/420*10)=-1.93288580414146 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ATP6AP2 [Title/Abstract] AND EIF3M [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ATP6AP2(40465889)-EIF3M(32611132), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ATP6AP2-EIF3M seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP6AP2-EIF3M seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ATP6AP2 | GO:0002003 | angiotensin maturation | 12045255|15746149 |
| Hgene | ATP6AP2 | GO:0032914 | positive regulation of transforming growth factor beta1 production | 16374430 |
| Hgene | ATP6AP2 | GO:0043408 | regulation of MAPK cascade | 12045255|15746149 |
| Fusion gene breakpoints across ATP6AP2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across EIF3M (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-G9-6348-01A | ATP6AP2 | chrX | 40465889 | - | EIF3M | chr11 | 32611132 | + |
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Fusion Gene ORF analysis for ATP6AP2-EIF3M |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000378438 | ENST00000532054 | ATP6AP2 | chrX | 40465889 | - | EIF3M | chr11 | 32611132 | + |
| In-frame | ENST00000378438 | ENST00000524896 | ATP6AP2 | chrX | 40465889 | - | EIF3M | chr11 | 32611132 | + |
| In-frame | ENST00000378438 | ENST00000531120 | ATP6AP2 | chrX | 40465889 | - | EIF3M | chr11 | 32611132 | + |
| intron-3CDS | ENST00000486558 | ENST00000524896 | ATP6AP2 | chrX | 40465889 | - | EIF3M | chr11 | 32611132 | + |
| intron-3CDS | ENST00000486558 | ENST00000531120 | ATP6AP2 | chrX | 40465889 | - | EIF3M | chr11 | 32611132 | + |
| intron-3CDS | ENST00000535539 | ENST00000524896 | ATP6AP2 | chrX | 40465889 | - | EIF3M | chr11 | 32611132 | + |
| intron-3CDS | ENST00000535539 | ENST00000531120 | ATP6AP2 | chrX | 40465889 | - | EIF3M | chr11 | 32611132 | + |
| intron-3CDS | ENST00000535777 | ENST00000524896 | ATP6AP2 | chrX | 40465889 | - | EIF3M | chr11 | 32611132 | + |
| intron-3CDS | ENST00000535777 | ENST00000531120 | ATP6AP2 | chrX | 40465889 | - | EIF3M | chr11 | 32611132 | + |
| intron-3CDS | ENST00000544975 | ENST00000524896 | ATP6AP2 | chrX | 40465889 | - | EIF3M | chr11 | 32611132 | + |
| intron-3CDS | ENST00000544975 | ENST00000531120 | ATP6AP2 | chrX | 40465889 | - | EIF3M | chr11 | 32611132 | + |
| intron-intron | ENST00000486558 | ENST00000532054 | ATP6AP2 | chrX | 40465889 | - | EIF3M | chr11 | 32611132 | + |
| intron-intron | ENST00000535539 | ENST00000532054 | ATP6AP2 | chrX | 40465889 | - | EIF3M | chr11 | 32611132 | + |
| intron-intron | ENST00000535777 | ENST00000532054 | ATP6AP2 | chrX | 40465889 | - | EIF3M | chr11 | 32611132 | + |
| intron-intron | ENST00000544975 | ENST00000532054 | ATP6AP2 | chrX | 40465889 | - | EIF3M | chr11 | 32611132 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000378438 | ATP6AP2 | chrX | 40465889 | - | ENST00000531120 | EIF3M | chr11 | 32611132 | + | 6603 | 2093 | 56 | 1210 | 384 |
| ENST00000378438 | ATP6AP2 | chrX | 40465889 | - | ENST00000524896 | EIF3M | chr11 | 32611132 | + | 3164 | 2093 | 56 | 1210 | 384 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000378438 | ENST00000531120 | ATP6AP2 | chrX | 40465889 | - | EIF3M | chr11 | 32611132 | + | 7.36E-05 | 0.9999263 |
| ENST00000378438 | ENST00000524896 | ATP6AP2 | chrX | 40465889 | - | EIF3M | chr11 | 32611132 | + | 9.81E-05 | 0.9999019 |
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Fusion Genomic Features for ATP6AP2-EIF3M |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for ATP6AP2-EIF3M |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:40465889/chr11:32611132) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ATP6AP2 | chrX:40465889 | chr11:32611132 | ENST00000378438 | - | 9 | 9 | 346_350 | 645 | 351.0 | Motif | Mediates retrograde transport to the ER |
| Hgene | ATP6AP2 | chrX:40465889 | chr11:32611132 | ENST00000378438 | - | 9 | 9 | 17_302 | 645 | 351.0 | Topological domain | Extracellular |
| Hgene | ATP6AP2 | chrX:40465889 | chr11:32611132 | ENST00000378438 | - | 9 | 9 | 324_350 | 645 | 351.0 | Topological domain | Cytoplasmic |
| Hgene | ATP6AP2 | chrX:40465889 | chr11:32611132 | ENST00000378438 | - | 9 | 9 | 303_323 | 645 | 351.0 | Transmembrane | Helical |
| Tgene | EIF3M | chrX:40465889 | chr11:32611132 | ENST00000531120 | 0 | 11 | 180_339 | 0 | 375.0 | Domain | PCI |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ATP6AP2-EIF3M |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >8072_8072_1_ATP6AP2-EIF3M_ATP6AP2_chrX_40465889_ENST00000378438_EIF3M_chr11_32611132_ENST00000524896_length(transcript)=3164nt_BP=2093nt GTGGAGAAAGCGGCAGCTGTCCCAGCGGAAGCGACGAAGGGACGGGACCCGGGAGCCTGGACGAGTCCGAGCGCGTCACCTCCTCACGCT GCGGCTGTCGCCCGTGTCCCGCCGGCCCGTTCCGTGTCGCCCCGCAGTGCTGCGGCCGCCGCGGCACCATGGCTGTGTTTGTCGTGCTCC TGGCGTTGGTGGCGGGTGTTTTGGGGAACGAGTTTAGTATATTAAAATCACCAGGGTCTGTTGTTTTCCGAAATGGAAATTGGCCTATAC CAGGAGAGCGGATCCCAGACGTGGCTGCATTGTCCATGGGCTTCTCTGTGAAAGAAGACCTTTCTTGGCCAGGACTCGCAGTGGGTAACC TGTTTCATCGTCCTCGGGCTACCGTCATGGTGATGGTGAAGGGAGTGAACAAACTGGCTCTACCCCCAGGCAGTGTCATTTCGTACCCTT TGGAGAATGCAGTTCCTTTTAGTCTTGACAGTGTTGCAAATTCCATTCACTCCTTATTTTCTGAGGAAACTCCTGTTGTTTTGCAGTTGG CTCCCAGTGAGGAAAGAGTGTATATGGTAGGGAAGGCAAACTCAGTGTTTGAAGACCTTTCAGTCACCTTGCGCCAGCTCCGTAATCGCC TGTTTCAAGAAAACTCTGTTCTCAGTTCACTCCCCCTCAATTCTCTGAGTAGGAACAATGAAGTTGACCTGCTCTTTCTTTCTGAACTGC AAGTGCTACATGATATTTCAAGCTTGCTGTCTCGTCATAAGCATCTAGCCAAGGATCATTCTCCTGATTTATATTCACTGGAGCTGGCAG GTTTGGATGAAATTGGGAAGCGTTATGGGGAAGACTCTGAACAATTCAGAGATGCTTCTAAGATCCTTGTTGACGCTCTGCAAAAGTTTG CAGATGACATGTACAGTCTTTATGGTGGGAATGCAGTGGTAGAGTTAGTCACTGTCAAGTCATTTGACACCTCCCTCATTAGGAAGACAA GGACTATCCTTGAGGCAAAACAAGCGAAGAACCCAGCAAGTCCCTATAACCTTGCATATAAGTATAATTTTGAATATTCCGTGGTTTTCA ACATGGTACTTTGGATAATGATCGCCTTGGCCTTGGCTGTGATTATCACCTCTTACAATATTTGGAACATGGATCCTGGATATGATAGCA TCATTTATAGGATGACAAACCAGAAGATTCGAATGGATTGAATGTTACCTGTGCCAGAATTAGAAAAGGGGGTTGGAAATTGGCTGTTTT GTTAAAATATATCTTTTAGTGTGCTTTAAAGTAGATAGTATACTTTACATTTATAAAAAAAAATCAAATTTTGTTCTTTATTTTGTGTGT GCCTGTGATGTTTTTCTAGAGTGAATTATAGTATTGACGTGAATCCCACTGTGGTATAGATTCCATAATATGCTTGAATATTATGATATA GCCATTTAATAACATTGATTTCATTCTGTTTAATGAATTTGGAAATATGCACTGAAAGAAATGTAAAACATTTAGAATAGCTCGTGTTAT GGAAAAAAGTGCACTGAATTTATTAGACAAACTTACGAATGCTTAACTTCTTTACACAGCATAGGTGAAAATCATATTTGGGCTATTGTA TACTATGAACAATTTGTAAATGTCTTAATTTGATGTAAATAACTCTGAAACAAGAGAAAAGGTTTTTAACTTAGAGTAGCCCTAAAATAT GGATGTGCTTATATAATCGCTTAGTTTTGGAACTGTATCTGAGTAACAGAGGACAGCTGTTTTTTAACCCTCTTCTGCAAGTTTGTTGAC CTACATGGGCTAATATGGATACTAAAAATACTACATTGATCTAAGAAGAAACTAGCCTTGTGGAGTATATAGATGCTTTTCATTATACAC ACAAAAATCCCTGAGGGACATTTTGAGGCATGAATATAAAACATTTTTATTTCAGTAACTTTTCCCCCTGTGTAAGTTACTATGGTTTGT GGTACAACTTCATTCTATAGAATATTAAGTGGAAGTGGGTGAATTCTACTTTTTATGTTGGAGTGGACCAATGTCTATCAAGAGTGACAA ATAAAGTTAATGATGATTCCAAAAAAAGCACACCCTTTTAAGACTACTTTATGAGGCACTTGTGGATTGTAAGAAGAGTGATGCTGCTTC AAAAGTCATGGTGGAATTGCTCGGAAGTTACACAGAGGACAATGCTTCCCAGGCTCGAGTTGATGCCCACAGGTGTATTGTACGAGCATT GAAAGATCCAAATGCATTTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGCGAGCTTATTCATGATCTTTTAAC CATTTTTGTGAGTGCTAAATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGATTCACTTGGCCTGTTACATGAACA GAATATGGCAAAAATGAGACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTTGACACAATGCAGCAAGAACTTCA GATTGGAGCTGATGATGTTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAAATTGATCAGACCCAGAGAAAAGT AGTTGTCAGTCATAGCACACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTTAATGCCTGGAAACAAAATCTGAA CAAAGTGAAAAACAGCCTTTTGAGTCTTTCTGATACCTGAGTTTTTATGCTTATAATTTTTGTTCTTTGAAAAAAAAGCCCTAAATCATA GTAAAACATTATAAACTAAAAAAATTTGCCTAGTCTGGACAGTTATTGTCTCAAATTTATACTAAAATCACAAACTCCAGAGGATATGAA GTAATAAATTACAAGGGGTCACAATGTCTGTCATACAATACATAAATTCTGTTCTTTAAAAAAGGATATTGAAGAAGCAATGAGCACTTT AAAGAAAGGATAATATACAGAGAGAAGACAGAAGTAGAGTAATACAATTTCTTCACATTAGAAAAACTTGGAAAAGCAAAGACAAACTGT AGAGCTTTAAATACAACAGTCATTTTATTCTAGTAAAAACTATACCAGAATTTCAGTTACATAATTTCACTACTGAAAGCACTTATCTAC >8072_8072_1_ATP6AP2-EIF3M_ATP6AP2_chrX_40465889_ENST00000378438_EIF3M_chr11_32611132_ENST00000524896_length(amino acids)=384AA_BP= MDESERVTSSRCGCRPCPAGPFRVAPQCCGRRGTMAVFVVLLALVAGVLGNEFSILKSPGSVVFRNGNWPIPGERIPDVAALSMGFSVKE DLSWPGLAVGNLFHRPRATVMVMVKGVNKLALPPGSVISYPLENAVPFSLDSVANSIHSLFSEETPVVLQLAPSEERVYMVGKANSVFED LSVTLRQLRNRLFQENSVLSSLPLNSLSRNNEVDLLFLSELQVLHDISSLLSRHKHLAKDHSPDLYSLELAGLDEIGKRYGEDSEQFRDA SKILVDALQKFADDMYSLYGGNAVVELVTVKSFDTSLIRKTRTILEAKQAKNPASPYNLAYKYNFEYSVVFNMVLWIMIALALAVIITSY -------------------------------------------------------------- >8072_8072_2_ATP6AP2-EIF3M_ATP6AP2_chrX_40465889_ENST00000378438_EIF3M_chr11_32611132_ENST00000531120_length(transcript)=6603nt_BP=2093nt GTGGAGAAAGCGGCAGCTGTCCCAGCGGAAGCGACGAAGGGACGGGACCCGGGAGCCTGGACGAGTCCGAGCGCGTCACCTCCTCACGCT GCGGCTGTCGCCCGTGTCCCGCCGGCCCGTTCCGTGTCGCCCCGCAGTGCTGCGGCCGCCGCGGCACCATGGCTGTGTTTGTCGTGCTCC TGGCGTTGGTGGCGGGTGTTTTGGGGAACGAGTTTAGTATATTAAAATCACCAGGGTCTGTTGTTTTCCGAAATGGAAATTGGCCTATAC CAGGAGAGCGGATCCCAGACGTGGCTGCATTGTCCATGGGCTTCTCTGTGAAAGAAGACCTTTCTTGGCCAGGACTCGCAGTGGGTAACC TGTTTCATCGTCCTCGGGCTACCGTCATGGTGATGGTGAAGGGAGTGAACAAACTGGCTCTACCCCCAGGCAGTGTCATTTCGTACCCTT TGGAGAATGCAGTTCCTTTTAGTCTTGACAGTGTTGCAAATTCCATTCACTCCTTATTTTCTGAGGAAACTCCTGTTGTTTTGCAGTTGG CTCCCAGTGAGGAAAGAGTGTATATGGTAGGGAAGGCAAACTCAGTGTTTGAAGACCTTTCAGTCACCTTGCGCCAGCTCCGTAATCGCC TGTTTCAAGAAAACTCTGTTCTCAGTTCACTCCCCCTCAATTCTCTGAGTAGGAACAATGAAGTTGACCTGCTCTTTCTTTCTGAACTGC AAGTGCTACATGATATTTCAAGCTTGCTGTCTCGTCATAAGCATCTAGCCAAGGATCATTCTCCTGATTTATATTCACTGGAGCTGGCAG GTTTGGATGAAATTGGGAAGCGTTATGGGGAAGACTCTGAACAATTCAGAGATGCTTCTAAGATCCTTGTTGACGCTCTGCAAAAGTTTG CAGATGACATGTACAGTCTTTATGGTGGGAATGCAGTGGTAGAGTTAGTCACTGTCAAGTCATTTGACACCTCCCTCATTAGGAAGACAA GGACTATCCTTGAGGCAAAACAAGCGAAGAACCCAGCAAGTCCCTATAACCTTGCATATAAGTATAATTTTGAATATTCCGTGGTTTTCA ACATGGTACTTTGGATAATGATCGCCTTGGCCTTGGCTGTGATTATCACCTCTTACAATATTTGGAACATGGATCCTGGATATGATAGCA TCATTTATAGGATGACAAACCAGAAGATTCGAATGGATTGAATGTTACCTGTGCCAGAATTAGAAAAGGGGGTTGGAAATTGGCTGTTTT GTTAAAATATATCTTTTAGTGTGCTTTAAAGTAGATAGTATACTTTACATTTATAAAAAAAAATCAAATTTTGTTCTTTATTTTGTGTGT GCCTGTGATGTTTTTCTAGAGTGAATTATAGTATTGACGTGAATCCCACTGTGGTATAGATTCCATAATATGCTTGAATATTATGATATA GCCATTTAATAACATTGATTTCATTCTGTTTAATGAATTTGGAAATATGCACTGAAAGAAATGTAAAACATTTAGAATAGCTCGTGTTAT GGAAAAAAGTGCACTGAATTTATTAGACAAACTTACGAATGCTTAACTTCTTTACACAGCATAGGTGAAAATCATATTTGGGCTATTGTA TACTATGAACAATTTGTAAATGTCTTAATTTGATGTAAATAACTCTGAAACAAGAGAAAAGGTTTTTAACTTAGAGTAGCCCTAAAATAT GGATGTGCTTATATAATCGCTTAGTTTTGGAACTGTATCTGAGTAACAGAGGACAGCTGTTTTTTAACCCTCTTCTGCAAGTTTGTTGAC CTACATGGGCTAATATGGATACTAAAAATACTACATTGATCTAAGAAGAAACTAGCCTTGTGGAGTATATAGATGCTTTTCATTATACAC ACAAAAATCCCTGAGGGACATTTTGAGGCATGAATATAAAACATTTTTATTTCAGTAACTTTTCCCCCTGTGTAAGTTACTATGGTTTGT GGTACAACTTCATTCTATAGAATATTAAGTGGAAGTGGGTGAATTCTACTTTTTATGTTGGAGTGGACCAATGTCTATCAAGAGTGACAA ATAAAGTTAATGATGATTCCAAAAAAAGCACACCCTTTTAAGACTACTTTATGAGGCACTTGTGGATTGTAAGAAGAGTGATGCTGCTTC AAAAGTCATGGTGGAATTGCTCGGAAGTTACACAGAGGACAATGCTTCCCAGGCTCGAGTTGATGCCCACAGGTGTATTGTACGAGCATT GAAAGATCCAAATGCATTTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGCGAGCTTATTCATGATCTTTTAAC CATTTTTGTGAGTGCTAAATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGATTCACTTGGCCTGTTACATGAACA GAATATGGCAAAAATGAGACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTTGACACAATGCAGCAAGAACTTCA GATTGGAGCTGATGATGTTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAAATTGATCAGACCCAGAGAAAAGT AGTTGTCAGTCATAGCACACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTTAATGCCTGGAAACAAAATCTGAA CAAAGTGAAAAACAGCCTTTTGAGTCTTTCTGATACCTGAGTTTTTATGCTTATAATTTTTGTTCTTTGAAAAAAAAGCCCTAAATCATA GTAAAACATTATAAACTAAAAAAATTTGCCTAGTCTGGACAGTTATTGTCTCAAATTTATACTAAAATCACAAACTCCAGAGGATATGAA GTAATAAATTACAAGGGGTCACAATGTCTGTCATACAATACATAAATTCTGTTCTTTAAAAAAGGATATTGAAGAAGCAATGAGCACTTT AAAGAAAGGATAATATACAGAGAGAAGACAGAAGTAGAGTAATACAATTTCTTCACATTAGAAAAACTTGGAAAAGCAAAGACAAACTGT AGAGCTTTAAATACAACAGTCATTTTATTCTAGTAAAAACTATACCAGAATTTCAGTTACATAATTTCACTACTGAAAGCACTTATCTAC ATTATTTTAATCTGTTGTTTTTTTCCAACGTCTCTTCTGCTTTTCTTTTCTTTGGCTGGTTGTCATTTTCTAAACTTAGTAAATTTTCAC TTTTATTTAGTTGATTCGTAATGAGGCTCTGCCAGTCATCATCACCAGAAGTATTTTTAGTCGTCTTGATTGCCTGCAAATGGCTTTGTA GTGGAGTTGATATCAGAGGCTTTGTTTTCACCTGGGAAAGATAAACTAATTTTACCTTCGAAATTATTATACAAAAGATTTTAAAGAGTC TGTAAAGCCTCTGCAGTTATGAGTATGTGGTAAAACCACCATCTCTTGGCTGATTTCCACTACCTTAGTAGTTCTGGCACCAGAAAAGTA TACAATGTGAATGTGTAGGCTTATGTAGTAGATCTTCAAAATCTCTAATATATAACTGAAGTAAAGTGTACAAAAACTGCCTTTTACTAC TTCATGTTTCCTCCCATGCTTCAGAACACCATTGTTGAAGAAACAGGAAGGGCAGTGAGATATTTGGAAGTTGGCATGTTTTCAAGACAC TGTATTGGGTAATTTTAAAAATAGTGTGTTAAATAACTTTTTCATTTTAAGGTTCTTTTCTGATGTTAAAATACTTACTGGAAATTTAGA AAATAGAGTAAAGTAGAAAGAAACTAAAAATCATTAGTAATCCCTTATCCAGAGAGGCTTGTTGACATTTTGGTATTATTTGCTGCTAGC GTTTTTTTCTATTTTTAGCCTATTTGATCATTCTATAGAATTTTATGTATTTTCCTCTGTGAGCAGTTTCTTAGGTCATTAAAAACAATT GTCTATGGCTGCAAAATACTCCCTTTTATGGATGTTTGATATATCTCCTACTACTGAATGTTTGTTTCCAGTTTATCCCTACCAAAAATT AATTCGAGTTAATTTCATGCAAAACAATCTTTGATGTTTTTGAGAGATTCCCAGATAAAATTTTCTCTTCAAAAGGAATACTGGGCCAGG CACTGTGACTCATACCTGTAATCCCAGCACTTTGGGAAACTGAGGCGAGTGGATTGCATGAGCTCAGGAGTCGAAAACTAGCCTGAGCAA CATGGCAAAACCCCATCTCTACCAAAAATTAGCTGGGCATGGTGGCATGCAACTGTAGTCCCAGCTCCTCGGAGGGCTGAGGTGCAAGGA TCATTTGAGCCCAGGAGGTGAAGGTTGCAATGAGCCAAGATCATGCCATTGCACTCCAGCCTGGACAACAGAGTGAGACCCTCTCTCAAA AATAAATAATAGATAAAACAAAAGGAATACTGAATTGTTTTCAAAATAACAATTATGGTGGGCTTTCTTTTAAGATAGGGTCTCACCCTG TCACCTAGGCTGGAGTGCAGTGGCACAATCACAGCTCATTGCAGCCTTGACCTCCCTGGATTCAGGTGATCCTCCCACCTTCACCTCCTG AGTACCTTGGACTACAGGCATGTGCCACCACACCCAGGTAATTTTTGTATTTTTTGCCATGTTGCCCAGGCTGGTCTCTCTTAACTCTTG GGCTCAAGTGATCTGACCATCTCGGTCTCCCAAAGTTCTAGGATTACAGGAGTGAGCCATACTGTGTTGTGTTTTAGTTGAAAGGGATAT ACACGTGTATTTTAGAAATATGAAACAGGATAAGAATTACATTAAAATCACCCAAGATCCCAACCACCATTAAAGAGTTTGTGTAAATCT TCTGGTCTCTTTTCTGTATACACTTTTTAAATACTGGGGTCATATTTTTATTGGTTTATATGCTATGTTAAACATTTTTAGCATTTCCTC CTGTTCTTAAGTCTGTTAAGAGGATAGCTCCATCATATTCTGTGTTCTGCAAATTATTTCTGGACATTTAAATTGTAAGAAAATGGTCAC TGTTAACTAGGCTGCAGTGATTATCATTTGTTCATAAATCTTTGTGAAGATCTTTGGGTACTGCCTTACATTAAAATCTTTTTCAATTTG ACCAGTAAAAGTGGCATGTTAGTAACATTGTCATTTTCAGTGTTAGATTATGTAGTACTAAGTTTATTTTATTTTATTTTTGAGACAGAG TCTTGCACTGTCGCCCAGGCTGGAGTGCAGTGGCGCCATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTTCTGCCTC AGCCTCCCGAGTAGCTGGGATTACAGGCACCCACCACGATGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATGTTG TCCAGGCTGGTCTCGAACGCCTGACCTCATGATCCACCTGCCTCGGCCTCCCAAAGTGTTGGGATTACAGGCATGAGCCACCCTGCCCGA CCTAGTAATACTTTTTTTTTTTTTTTTTTTTAATGAACTTAAATGTTTAGAATGGTAAGTTCACGGCTCCCTAAGGAGTGTTCCTTTTGG ATTGCTCTGTTTGGCTCCCTCCCTGAAATCCTATAGTCAGCCACTGGTCCCCTCAGAGAGTTTTACCTCTGATCTTTGGGGTGATTCTTT GTTCATATTTATCTGATTGGCTTTGTTCTTCCAAAAGTGTCTGCACAGGACTGCTAAGAGAACCTAGGCAAGTCATTTAATTTTTCTGGG CTTCAGTTTACTCATTAGCTTCTTTTAGTTCCCAGATGCTATTACTGGAAAGAATAACTAGTAATGGATAAAAACCTACATAAATATTTC CTATTTTGCCATCAAAGTGCTGGGTTCATTTTGGTGTATTTGGCATCCAAGTACAAATTAACAGTTTCCCAAAATCCTGATTCTTTGACT TTTTTATCTTGATGATGGAAAGGAAGGACACGTTTACTTGCTTTAGTTTCTTTCCCCTTAACTACCCACTTGCTGAGAGGGGTAGGAGCA GGGATTGGCTTTAGAGAAACAAGATACAGTGTAGATTAGCTAATGTTTGCGCTTAACAAAACTTGTCCTGTTTAACTTACCTGAGGGTTC TGCAGCCTACCGCAGTAATTTTAGTTCTAGCTGTTTTCAGATATATTGCCTTGTATCTTCGTTCTTTCGTCTCCTATCCTTTTTAGAAAT TTATCACCTGTTTCTCTTTCAGCCTGACTTACAAAATCTAATTTTTGGCCTAAAAATTTCCCCTAGCTTGGTACTAGTCCTTTTATTTCT GCCTGTGATTATATTTTAAAATTAAACTTAAATGAATCTAATTCATTGGATATATAAAAAAAAAAGTAAGTGGCTTGCTTTGCTTACTCT GGTTTTCCATCCTCATTCCTGGATATAATCAAGATTGCAGTAGGCTAACAATCTAATGCTGAAAACAAGAATGAAAAACATACCATCTTT TCAAGTTACTTTGGACCCATAGAGAGAAAGTGGATTGGTACTTAATACCTTCCCTGAATTTAACAGAATTGATGTGGACTGTACATAAAA >8072_8072_2_ATP6AP2-EIF3M_ATP6AP2_chrX_40465889_ENST00000378438_EIF3M_chr11_32611132_ENST00000531120_length(amino acids)=384AA_BP= MDESERVTSSRCGCRPCPAGPFRVAPQCCGRRGTMAVFVVLLALVAGVLGNEFSILKSPGSVVFRNGNWPIPGERIPDVAALSMGFSVKE DLSWPGLAVGNLFHRPRATVMVMVKGVNKLALPPGSVISYPLENAVPFSLDSVANSIHSLFSEETPVVLQLAPSEERVYMVGKANSVFED LSVTLRQLRNRLFQENSVLSSLPLNSLSRNNEVDLLFLSELQVLHDISSLLSRHKHLAKDHSPDLYSLELAGLDEIGKRYGEDSEQFRDA SKILVDALQKFADDMYSLYGGNAVVELVTVKSFDTSLIRKTRTILEAKQAKNPASPYNLAYKYNFEYSVVFNMVLWIMIALALAVIITSY -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ATP6AP2-EIF3M |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | EIF3M | chrX:40465889 | chr11:32611132 | ENST00000531120 | 0 | 11 | 344_374 | 0 | 375.0 | HSV-1 and HSV-2 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ATP6AP2-EIF3M |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ATP6AP2-EIF3M |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ATP6AP2 | C1845543 | Mental Retardation, X-Linked, with Epilepsy | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
| Hgene | ATP6AP2 | C0016059 | Fibrosis | 1 | CTD_human |
| Hgene | ATP6AP2 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| Hgene | ATP6AP2 | C1623038 | Cirrhosis | 1 | CTD_human |
| Hgene | ATP6AP2 | C3806722 | PARKINSONISM WITH SPASTICITY, X-LINKED | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
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