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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TGOLN2-IMMT (FusionGDB2 ID:HG10618TG10989)

Fusion Gene Summary for TGOLN2-IMMT

check button Fusion gene summary
Fusion gene informationFusion gene name: TGOLN2-IMMT
Fusion gene ID: hg10618tg10989
HgeneTgene
Gene symbol

TGOLN2

IMMT

Gene ID

10618

10989

Gene nametrans-golgi network protein 2inner membrane mitochondrial protein
SynonymsTGN38|TGN46|TGN48|TGN51|TTGN2|hTGN46|hTGN48|hTGN51HMP|MICOS60|MINOS2|Mic60|P87|P87/89|P89|PIG4|PIG52
Cytomap('TGOLN2')('IMMT')

2p11.2

2p11.2|2

Type of geneprotein-codingprotein-coding
Descriptiontrans-Golgi network integral membrane protein 2TGN38 homologtrans-Golgi network glycoprotein 46trans-Golgi network glycoprotein 48trans-Golgi network glycoprotein 51trans-Golgi network protein (46, 48, 51kD isoforms)trans-Golgi network protein TGN51MICOS complex subunit MIC60cell proliferation-inducing gene 4/52 proteincell proliferation-inducing protein 52heart muscle proteinmitochondrial contact site and cristae organizing system subunit 60mitochondrial inner membrane organizing system 2mito
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000282120, ENST00000377386, 
ENST00000398263, ENST00000409015, 
ENST00000409232, ENST00000444342, 
Fusion gene scores* DoF score10 X 11 X 5=55014 X 12 X 7=1176
# samples 1216
** MAII scorelog2(12/550*10)=-2.1963972128035
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1176*10)=-2.877744249949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TGOLN2 [Title/Abstract] AND IMMT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTGOLN2(85552038)-IMMT(86372004), # samples:3
Anticipated loss of major functional domain due to fusion event.TGOLN2-IMMT seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TGOLN2-IMMT seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-PG-A7D5-01ATGOLN2chr2

85552038

-IMMTchr2

86372004

-
ChimerDB4UCECTCGA-PG-A7D5TGOLN2chr2

85552037

-IMMTchr2

86372004

-


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Fusion Gene ORF analysis for TGOLN2-IMMT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000282120ENST00000490238TGOLN2chr2

85552038

-IMMTchr2

86372004

-
5CDS-intronENST00000282120ENST00000490238TGOLN2chr2

85552037

-IMMTchr2

86372004

-
5CDS-intronENST00000377386ENST00000490238TGOLN2chr2

85552038

-IMMTchr2

86372004

-
5CDS-intronENST00000377386ENST00000490238TGOLN2chr2

85552037

-IMMTchr2

86372004

-
5CDS-intronENST00000398263ENST00000490238TGOLN2chr2

85552038

-IMMTchr2

86372004

-
5CDS-intronENST00000398263ENST00000490238TGOLN2chr2

85552037

-IMMTchr2

86372004

-
5CDS-intronENST00000409015ENST00000490238TGOLN2chr2

85552038

-IMMTchr2

86372004

-
5CDS-intronENST00000409015ENST00000490238TGOLN2chr2

85552037

-IMMTchr2

86372004

-
5CDS-intronENST00000409232ENST00000490238TGOLN2chr2

85552038

-IMMTchr2

86372004

-
5CDS-intronENST00000409232ENST00000490238TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000282120ENST00000254636TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000282120ENST00000254636TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000282120ENST00000409051TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000282120ENST00000409051TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000282120ENST00000410111TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000282120ENST00000410111TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000282120ENST00000442664TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000282120ENST00000442664TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000282120ENST00000449247TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000282120ENST00000449247TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000377386ENST00000254636TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000377386ENST00000254636TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000377386ENST00000409051TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000377386ENST00000409051TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000377386ENST00000410111TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000377386ENST00000410111TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000377386ENST00000442664TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000377386ENST00000442664TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000377386ENST00000449247TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000377386ENST00000449247TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000398263ENST00000254636TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000398263ENST00000254636TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000398263ENST00000409051TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000398263ENST00000409051TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000398263ENST00000410111TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000398263ENST00000410111TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000398263ENST00000442664TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000398263ENST00000442664TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000398263ENST00000449247TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000398263ENST00000449247TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000409015ENST00000254636TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000409015ENST00000254636TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000409015ENST00000409051TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000409015ENST00000409051TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000409015ENST00000410111TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000409015ENST00000410111TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000409015ENST00000442664TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000409015ENST00000442664TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000409015ENST00000449247TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000409015ENST00000449247TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000409232ENST00000254636TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000409232ENST00000254636TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000409232ENST00000409051TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000409232ENST00000409051TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000409232ENST00000410111TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000409232ENST00000410111TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000409232ENST00000442664TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000409232ENST00000442664TGOLN2chr2

85552037

-IMMTchr2

86372004

-
Frame-shiftENST00000409232ENST00000449247TGOLN2chr2

85552038

-IMMTchr2

86372004

-
Frame-shiftENST00000409232ENST00000449247TGOLN2chr2

85552037

-IMMTchr2

86372004

-
intron-3CDSENST00000444342ENST00000254636TGOLN2chr2

85552038

-IMMTchr2

86372004

-
intron-3CDSENST00000444342ENST00000254636TGOLN2chr2

85552037

-IMMTchr2

86372004

-
intron-3CDSENST00000444342ENST00000409051TGOLN2chr2

85552038

-IMMTchr2

86372004

-
intron-3CDSENST00000444342ENST00000409051TGOLN2chr2

85552037

-IMMTchr2

86372004

-
intron-3CDSENST00000444342ENST00000410111TGOLN2chr2

85552038

-IMMTchr2

86372004

-
intron-3CDSENST00000444342ENST00000410111TGOLN2chr2

85552037

-IMMTchr2

86372004

-
intron-3CDSENST00000444342ENST00000442664TGOLN2chr2

85552038

-IMMTchr2

86372004

-
intron-3CDSENST00000444342ENST00000442664TGOLN2chr2

85552037

-IMMTchr2

86372004

-
intron-3CDSENST00000444342ENST00000449247TGOLN2chr2

85552038

-IMMTchr2

86372004

-
intron-3CDSENST00000444342ENST00000449247TGOLN2chr2

85552037

-IMMTchr2

86372004

-
intron-intronENST00000444342ENST00000490238TGOLN2chr2

85552038

-IMMTchr2

86372004

-
intron-intronENST00000444342ENST00000490238TGOLN2chr2

85552037

-IMMTchr2

86372004

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TGOLN2-IMMT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for TGOLN2-IMMT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:85552038/:86372004)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TGOLN2-IMMT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TGOLN2-IMMT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TGOLN2-IMMT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TGOLN2-IMMT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTGOLN2C0040128Thyroid Diseases1CTD_human
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0029408Degenerative polyarthritis1CTD_human
TgeneC0086743Osteoarthrosis Deformans1CTD_human
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human