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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADCY3-UBR4 (FusionGDB2 ID:HG109TG23352)

Fusion Gene Summary for ADCY3-UBR4

check button Fusion gene summary
Fusion gene informationFusion gene name: ADCY3-UBR4
Fusion gene ID: hg109tg23352
HgeneTgene
Gene symbol

ADCY3

UBR4

Gene ID

109

23352

Gene nameadenylate cyclase 3ubiquitin protein ligase E3 component n-recognin 4
SynonymsAC-III|AC3|BMIQ19RBAF600|ZUBR1|p600
Cytomap('ADCY3')('UBR4')

2p23.3

1p36.13

Type of geneprotein-codingprotein-coding
Descriptionadenylate cyclase type 3ATP pyrophosphate-lyase 3adenylate cyclase type IIIadenylate cyclase, olfactive typeadenylyl cyclase 3adenylyl cyclase, type IIIE3 ubiquitin-protein ligase UBR4N-recognin-4RING-type E3 ubiquitin transferase UBR4retinoblastoma-associated factor 600-like proteinretinoblastoma-associated factor of 600 kDazinc finger UBR1-type protein 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000260600, ENST00000405392, 
ENST00000450524, 
Fusion gene scores* DoF score7 X 6 X 5=21014 X 16 X 7=1568
# samples 716
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1568*10)=-3.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADCY3 [Title/Abstract] AND UBR4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADCY3(25043593)-UBR4(19436958), # samples:1
Anticipated loss of major functional domain due to fusion event.ADCY3-UBR4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCY3-UBR4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCY3-UBR4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCY3-UBR4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCY3-UBR4 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ADCY3-UBR4 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ADCY3-UBR4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUBR4

GO:0006511

ubiquitin-dependent protein catabolic process

23932781


check buttonFusion gene breakpoints across ADCY3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across UBR4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR188387ADCY3chr2

25043593

-UBR4chr1

19436958

-


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Fusion Gene ORF analysis for ADCY3-UBR4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000260600ENST00000375218ADCY3chr2

25043593

-UBR4chr1

19436958

-
5CDS-intronENST00000260600ENST00000375224ADCY3chr2

25043593

-UBR4chr1

19436958

-
5CDS-intronENST00000260600ENST00000375225ADCY3chr2

25043593

-UBR4chr1

19436958

-
5CDS-intronENST00000260600ENST00000429347ADCY3chr2

25043593

-UBR4chr1

19436958

-
5CDS-intronENST00000260600ENST00000467272ADCY3chr2

25043593

-UBR4chr1

19436958

-
5CDS-intronENST00000260600ENST00000543981ADCY3chr2

25043593

-UBR4chr1

19436958

-
5CDS-intronENST00000405392ENST00000375218ADCY3chr2

25043593

-UBR4chr1

19436958

-
5CDS-intronENST00000405392ENST00000375224ADCY3chr2

25043593

-UBR4chr1

19436958

-
5CDS-intronENST00000405392ENST00000375225ADCY3chr2

25043593

-UBR4chr1

19436958

-
5CDS-intronENST00000405392ENST00000429347ADCY3chr2

25043593

-UBR4chr1

19436958

-
5CDS-intronENST00000405392ENST00000467272ADCY3chr2

25043593

-UBR4chr1

19436958

-
5CDS-intronENST00000405392ENST00000543981ADCY3chr2

25043593

-UBR4chr1

19436958

-
Frame-shiftENST00000405392ENST00000375217ADCY3chr2

25043593

-UBR4chr1

19436958

-
Frame-shiftENST00000405392ENST00000375226ADCY3chr2

25043593

-UBR4chr1

19436958

-
Frame-shiftENST00000405392ENST00000375254ADCY3chr2

25043593

-UBR4chr1

19436958

-
Frame-shiftENST00000405392ENST00000375267ADCY3chr2

25043593

-UBR4chr1

19436958

-
In-frameENST00000260600ENST00000375217ADCY3chr2

25043593

-UBR4chr1

19436958

-
In-frameENST00000260600ENST00000375226ADCY3chr2

25043593

-UBR4chr1

19436958

-
In-frameENST00000260600ENST00000375254ADCY3chr2

25043593

-UBR4chr1

19436958

-
In-frameENST00000260600ENST00000375267ADCY3chr2

25043593

-UBR4chr1

19436958

-
intron-3CDSENST00000450524ENST00000375217ADCY3chr2

25043593

-UBR4chr1

19436958

-
intron-3CDSENST00000450524ENST00000375226ADCY3chr2

25043593

-UBR4chr1

19436958

-
intron-3CDSENST00000450524ENST00000375254ADCY3chr2

25043593

-UBR4chr1

19436958

-
intron-3CDSENST00000450524ENST00000375267ADCY3chr2

25043593

-UBR4chr1

19436958

-
intron-intronENST00000450524ENST00000375218ADCY3chr2

25043593

-UBR4chr1

19436958

-
intron-intronENST00000450524ENST00000375224ADCY3chr2

25043593

-UBR4chr1

19436958

-
intron-intronENST00000450524ENST00000375225ADCY3chr2

25043593

-UBR4chr1

19436958

-
intron-intronENST00000450524ENST00000429347ADCY3chr2

25043593

-UBR4chr1

19436958

-
intron-intronENST00000450524ENST00000467272ADCY3chr2

25043593

-UBR4chr1

19436958

-
intron-intronENST00000450524ENST00000543981ADCY3chr2

25043593

-UBR4chr1

19436958

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000260600ADCY3chr225043593-ENST00000375217UBR4chr119436958-8090410485277632303
ENST00000260600ADCY3chr225043593-ENST00000375226UBR4chr119436958-8090410485277632303
ENST00000260600ADCY3chr225043593-ENST00000375267UBR4chr119436958-8153410485278262324
ENST00000260600ADCY3chr225043593-ENST00000375254UBR4chr119436958-8090410485277632303

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000260600ENST00000375217ADCY3chr225043593-UBR4chr119436958-0.0060887310.99391127
ENST00000260600ENST00000375226ADCY3chr225043593-UBR4chr119436958-0.0060887310.99391127
ENST00000260600ENST00000375267ADCY3chr225043593-UBR4chr119436958-0.0050649150.9949351
ENST00000260600ENST00000375254ADCY3chr225043593-UBR4chr119436958-0.0060887310.99391127

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Fusion Genomic Features for ADCY3-UBR4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ADCY3-UBR4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:25043593/chr1:19436958)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-20211062_106410841145.0Nucleotide bindingATP
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-20211069_107310841145.0Nucleotide bindingATP
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-2021324_32910841145.0Nucleotide bindingATP
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-2021366_36810841145.0Nucleotide bindingATP
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-20211_7910841145.0Topological domainCytoplasmic
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-2021402_63210841145.0Topological domainCytoplasmic
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-2021105_12510841145.0TransmembraneHelical
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-2021139_15910841145.0TransmembraneHelical
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-2021173_19310841145.0TransmembraneHelical
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-2021226_24610841145.0TransmembraneHelical
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-2021381_40110841145.0TransmembraneHelical
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-2021633_65310841145.0TransmembraneHelical
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-2021664_68410841145.0TransmembraneHelical
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-2021708_72810841145.0TransmembraneHelical
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-2021754_77410841145.0TransmembraneHelical
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-2021775_79510841145.0TransmembraneHelical
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-202180_10010841145.0TransmembraneHelical
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-2021833_85310841145.0TransmembraneHelical
TgeneUBR4chr2:25043593chr1:19436958ENST00000375218052728_27380213.0Compositional biasNote=Poly-Asp
TgeneUBR4chr2:25043593chr1:19436958ENST00000375218053339_33700213.0Compositional biasNote=Ser-rich
TgeneUBR4chr2:25043593chr1:19436958ENST0000037521805608_6310213.0Compositional biasNote=Pro-rich
TgeneUBR4chr2:25043593chr1:19436958ENST00000375218059_150213.0Compositional biasNote=Poly-Ala
TgeneUBR4chr2:25043593chr1:19436958ENST0000037521805850_8700213.0TransmembraneHelical
TgeneUBR4chr2:25043593chr1:19436958ENST0000037521805993_10130213.0TransmembraneHelical
TgeneUBR4chr2:25043593chr1:19436958ENST00000375218051656_17290213.0Zinc fingerUBR-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCY3chr2:25043593chr1:19436958ENST00000260600-2021854_114410841145.0Topological domainCytoplasmic
TgeneUBR4chr2:25043593chr1:19436958ENST00000375217781062728_273839575177.0Compositional biasNote=Poly-Asp
TgeneUBR4chr2:25043593chr1:19436958ENST00000375217781063339_337039575177.0Compositional biasNote=Ser-rich
TgeneUBR4chr2:25043593chr1:19436958ENST0000037521778106608_63139575177.0Compositional biasNote=Pro-rich
TgeneUBR4chr2:25043593chr1:19436958ENST00000375217781069_1539575177.0Compositional biasNote=Poly-Ala
TgeneUBR4chr2:25043593chr1:19436958ENST00000375226781062728_273839405160.0Compositional biasNote=Poly-Asp
TgeneUBR4chr2:25043593chr1:19436958ENST00000375226781063339_337039405160.0Compositional biasNote=Ser-rich
TgeneUBR4chr2:25043593chr1:19436958ENST0000037522678106608_63139405160.0Compositional biasNote=Pro-rich
TgeneUBR4chr2:25043593chr1:19436958ENST00000375226781069_1539405160.0Compositional biasNote=Poly-Ala
TgeneUBR4chr2:25043593chr1:19436958ENST00000375254781062728_273839645184.0Compositional biasNote=Poly-Asp
TgeneUBR4chr2:25043593chr1:19436958ENST00000375254781063339_337039645184.0Compositional biasNote=Ser-rich
TgeneUBR4chr2:25043593chr1:19436958ENST0000037525478106608_63139645184.0Compositional biasNote=Pro-rich
TgeneUBR4chr2:25043593chr1:19436958ENST00000375254781069_1539645184.0Compositional biasNote=Poly-Ala
TgeneUBR4chr2:25043593chr1:19436958ENST00000375267781072728_273839645205.0Compositional biasNote=Poly-Asp
TgeneUBR4chr2:25043593chr1:19436958ENST00000375267781073339_337039645205.0Compositional biasNote=Ser-rich
TgeneUBR4chr2:25043593chr1:19436958ENST0000037526778107608_63139645205.0Compositional biasNote=Pro-rich
TgeneUBR4chr2:25043593chr1:19436958ENST00000375267781079_1539645205.0Compositional biasNote=Poly-Ala
TgeneUBR4chr2:25043593chr1:19436958ENST0000037521778106850_87039575177.0TransmembraneHelical
TgeneUBR4chr2:25043593chr1:19436958ENST0000037521778106993_101339575177.0TransmembraneHelical
TgeneUBR4chr2:25043593chr1:19436958ENST0000037522678106850_87039405160.0TransmembraneHelical
TgeneUBR4chr2:25043593chr1:19436958ENST0000037522678106993_101339405160.0TransmembraneHelical
TgeneUBR4chr2:25043593chr1:19436958ENST0000037525478106850_87039645184.0TransmembraneHelical
TgeneUBR4chr2:25043593chr1:19436958ENST0000037525478106993_101339645184.0TransmembraneHelical
TgeneUBR4chr2:25043593chr1:19436958ENST0000037526778107850_87039645205.0TransmembraneHelical
TgeneUBR4chr2:25043593chr1:19436958ENST0000037526778107993_101339645205.0TransmembraneHelical
TgeneUBR4chr2:25043593chr1:19436958ENST00000375217781061656_172939575177.0Zinc fingerUBR-type
TgeneUBR4chr2:25043593chr1:19436958ENST00000375226781061656_172939405160.0Zinc fingerUBR-type
TgeneUBR4chr2:25043593chr1:19436958ENST00000375254781061656_172939645184.0Zinc fingerUBR-type
TgeneUBR4chr2:25043593chr1:19436958ENST00000375267781071656_172939645205.0Zinc fingerUBR-type


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Fusion Gene Sequence for ADCY3-UBR4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2235_2235_1_ADCY3-UBR4_ADCY3_chr2_25043593_ENST00000260600_UBR4_chr1_19436958_ENST00000375217_length(transcript)=8090nt_BP=4104nt
CGGGCCTGACGGCGGGAGATCGCGCTCCGGCCGGGCCCCGAGGCGCTGCCGGGGCGGCGCGGCTCTGCGGGGAGCAGCCCTCGGGCGCGC
CGAGCTCTCCCGCCCCAGCCCGCGCGGGGACCGTCCCGGAGCACGCGGTGGCCGAGTTCCCGCACAGGTAAACGCAGGGGCAGGGCCAGG
CTTCCGGGGGGGAAGACAGCGCCCCGAGCGTGGGAAGGGGGCCGGATCGGAGCCCGAGCCTCCAAGGGTTTGGTGGAAAAAGGAAGTAAA
CAGAAGGAAGGCTCAGGAATCCCCCACGATGGTCCTGATTTCTTTCCGGCACATTTTATTTACAGCTTCTAAGGACTGGGCCTGGAGGGA
ATTTAGGTGAGGAAGTCGGGGACTGAGAAAGAAGAGATGACAGAGAGAAACCGGTTACCAGGGATGGAAAGGCGGCTAGGCCCTTCCACA
AGCCAGGGACAGGAAATTGAGTGTCTGGCGTGGACAGGACTAAGTGTGCCTGCGGTGGGCGGTGGTGTGAGCCGGGGGTGGCAGGGAAGG
CCCTGGGTTGGGAGGCTCTTGCAGCAGAGATCCTTTTATGAGGGTTAGGGCGGGTCATGGGGAAACCGCAAGGTAGGAGGGAAGAGGTGC
TTCTACTCAGCAATGCCCTTTTCAGTTCTAGCTGATCAGTGCTACCTGTGCTCTGGAAACCCGCTCTGCGTTCCTGCTGGAGGTGGCCTC
CCCTCCGCCCCAGACAAGAAGAGGCCCTCAGCCCTCCCCCGGTCTCAGAGAGCCCTGAGAGGAGGCCCAGTCCAGAGCTCTTCCTCCGTT
CCCAGTCCACTTCTCTAGGGCCAGTAGCAGACACCAGCCAGTATGCCGAGGAACCAGGGCTTCTCCGAGCCCGAATACTCGGCCGAGTAC
TCAGCCGAGTACTCCGTCAGCCTGCCCTCCGACCCTGACCGCGGGGTGGGCCGGACCCATGAAATCTCGGTCCGGAACTCGGGCTCCTGC
CTGTGCCTGCCTCGCTTCATGCGGCTGACTTTCGTGCCGGAGTCCTTGGAGAACCTCTACCAGACCTACTTCAAAAGGCAGCGCCACGAG
ACCCTGCTGGTGCTGGTGGTCTTTGCAGCCCTCTTTGACTGCTACGTGGTGGTCATGTGTGCTGTGGTCTTCTCCAGCGACAAGCTGGCT
TCCCTCGCCGTGGCTGGAATTGGACTGGTGTTGGACATCATCCTCTTCGTGCTCTGCAAAAAGGGGCTGCTCCCGGACCGGGTCACCCGC
AGAGTGCTGCCCTACGTGCTGTGGCTGCTCATAACCGCCCAGATCTTCTCCTACCTGGGCCTGAACTTCGCGCGTGCCCACGCGGCTAGT
GACACGGTGGGCTGGCAGGTCTTCTTTGTCTTCTCCTTCTTCATCACGCTGCCCCTCAGCCTCAGCCCCATCGTGATCATCTCCGTGGTC
TCCTGTGTGGTGCACACGTTGGTCCTGGGGGTCACCGTGGCCCAGCAGCAGCAGGAGGAGCTCAAGGGGATGCAGCTGCTGCGGGAGATC
CTGGCCAACGTCTTCCTCTACCTGTGCGCCATCGCTGTGGGCATCATGTCCTACTACATGGCTGACCGCAAGCACCGCAAGGCCTTCCTG
GAGGCCCGCCAGTCGCTGGAGGTGAAGATGAACCTGGAAGAGCAGAGCCAGCAGCAGGAGAACCTCATGCTTTCCATCCTGCCCAAGCAC
GTGGCTGACGAGATGCTGAAAGACATGAAGAAAGACGAGAGCCAGAAGGACCAGCAGCAGTTCAACACCATGTACATGTACCGTCACGAG
AACGTCAGCATCCTCTTTGCCGACATCGTGGGCTTTACCCAGCTGTCTTCTGCCTGCAGTGCCCAGGAGCTTGTGAAGCTGCTCAACGAG
CTCTTTGCCCGCTTTGACAAGCTGGCAGCTAAATACCACCAGCTGCGGATTAAGATCCTGGGCGACTGCTACTACTGCATCTGCGGCTTG
CCCGACTACCGGGAGGACCACGCCGTCTGCTCCATCCTCATGGGGCTGGCCATGGTGGAGGCCATCTCGTATGTGCGGGAGAAGACCAAG
ACTGGGGTGGACATGCGTGTGGGGGTGCACACGGGCACCGTGCTGGGGGGCGTCCTGGGCCAGAAGCGCTGGCAGTACGACGTGTGGTCG
ACTGATGTCACTGTAGCCAACAAGATGGAGGCCGGCGGCATCCCTGGGCGCGTGCACATCTCCCAGAGCACCATGGACTGCCTGAAAGGG
GAGTTTGATGTGGAGCCAGGCGATGGGGGCAGCCGCTGTGATTACCTAGAAGAGAAGGGTATTGAAACCTACCTCATCATTGCCTCCAAG
CCAGAGGTGAAGAAAACAGCCACCCAGAATGGCCTCAATGGCTCGGCCCTGCCCAATGGAGCACCAGCTTCCTCAAAGTCCAGCTCCCCT
GCCCTCATTGAGACCAAGGAGCCCAACGGGAGTGCCCACAGCAGTGGGTCCACGTCGGAGAAGCCCGAGGAGCAGGATGCCCAGGCCGAC
AACCCCTCATTCCCCAACCCACGCCGGAGGCTGCGCCTGCAGGACCTGGCTGACCGAGTGGTGGATGCCTCTGAAGATGAGCACGAGCTC
AACCAGCTGCTCAACGAGGCCCTGCTTGAGCGAGAGTCCGCCCAAGTAGTAAAGAAGAGAAACACCTTCCTCTTGTCCATGCGGTTCATG
GACCCCGAGATGGAAACCCGCTACTCGGTGGAGAAGGAGAAGCAGAGTGGGGCTGCCTTCAGCTGCTCCTGCGTCGTCCTGCTCTGCACG
GCCCTGGTCGAGATACTCATCGACCCCTGGCTAATGACAAACTATGTGACCTTCATGGTGGGGGAGATTCTGCTCCTCATCCTGACCATC
TGCTCCCTGGCTGCCATCTTTCCCCGGGCCTTTCCTAAGAAGCTTGTGGCCTTCTCAACTTGGATTGACCGGACCCGCTGGGCCAGGAAC
ACCTGGGCCATGCTCGCCATCTTCATCCTGGTGATGGCAAATGTCGTGGACATGCTCAGCTGTCTCCAGTACTACACGGGACCCAGCAAT
GCAACGGCAGGGATGGAAACGGAGGGCAGCTGCCTGGAGAACCCCAAGTATTACAACTATGTGGCCGTGCTGTCCCTCATCGCCACCATC
ATGCTGGTGCAGGTCAGCCACATGGTGAAGCTCACGCTCATGCTGCTCGTCGCAGGCGCCGTGGCCACCATCAACCTCTATGCCTGGCGT
CCCGTCTTTGATGAATACGACCACAAGCGTTTTCGGGAGCACGACTTACCTATGGTGGCCTTAGAGCAGATGCAAGGATTCAACCCTGGG
CTCAATGGCACTGACAGGCTGCCCCTGGTGCCTTCCAAGTACTCTATGACGGTGATGGTGTTCCTCATGATGCTCAGCTTCTACTACTTC
TCCCGCCACGTAGAAAAACTGGCACGGACACTTTTCTTGTGGAAGATTGAGGTCCACGACCAGAAGGAACGTGTCTATGAGATGCGACGC
TGGAACGAGGCCTTGGTCACCAACATGTTGCCTGAGCACGTGGCACGCCATTTCCTGGGGTCCAAGAAGAGAGATGAGGAGCTGTATAGC
CAGACGTATGATGAGATTGGAGTCATGTTTGCCTCCCTGCCCAACTTTGCTGACTTCTACACAGAGGAGAGCATCAACAATGGTGGTATT
GAGTGTCTGCGTTTCCTCAATGAAATCATCTCAGATTTTGACTCTCTCCTGGACAATCCCAAGTTCCGGGTGATCACCAAGATCAAAACC
ATTGGCAGCACGTATATGGCGGCTTCAGGAGTCACCCCCGATGTCAACACCAATGGCTTTGCCAGCTCCAACAAGGAAGACAAGTCCGAG
AGAGAGCGCTGGCAGCACCTGGCTGACCTGGCCGACTTCGCGCTGGCCATGAAGGATACGCTCACCAACATCAACAACCAGTCCTTCAAT
AACTTCATGCTGCGCATAGGCATGAACAAAGGCGGGGTTCTGGCTGGGGTCATCGGAGCCCGGAAACCACACTACGACATCTGGGGCAAT
ACAGTCAATGTAGCCAGCAGGATGGAGTCCACGGGGGTCATGGGCAACATTCAGGCAAGTAGCCTGCAGTATGAAATGCTGCTGCTGACG
GATTCTATCTCCAAGGAGGACAGCTGCTGGGAGCTCCGGTTACGCTGTGCTCTCAGCCTTTTCCTCATGGCTGTGAACATTAAGACTCCT
GTGGTGGTTGAAAACATTACCCTCATGTGCCTGAGGATCTTGCAGAAGCTGATAAAACCACCTGCTCCCACTAGCAAGAAGAACAAGGAT
GTCCCCGTTGAGGCCCTCACCACGGTGAAGCCATACTGCAATGAGATCCATGCCCAGGCTCAACTGTGGCTCAAGAGAGACCCCAAGGCA
TCCTATGATGCCTGGAAGAAGTGTCTTCCTATCAGAGGGATAGATGGCAATGGGAAAGCCCCCAGCAAATCAGAGCTCCGCCATCTCTAT
TTGACTGAGAAGTATGTGTGGAGGTGGAAACAGTTCCTGAGTCGTCGGGGGAAGAGGACCTCCCCCTTGGATCTCAAACTGGGGCATAAC
AACTGGCTGCGACAAGTGCTTTTCACTCCAGCAACGCAGGCCGCACGGCAGGCAGCCTGTACCATTGTGGAAGCTCTAGCCACCATTCCC
AGCCGCAAGCAGCAGGTCCTGGACCTGCTTACCAGTTACCTGGATGAGCTGAGCATAGCTGGGGAGTGTGCAGCTGAGTACCTGGCTCTC
TACCAGAAGCTCATCACTTCTGCGCACTGGAAAGTCTACTTGGCAGCTCGGGGAGTCCTACCCTATGTGGGCAACCTCATCACCAAGGAA
ATAGCTCGTCTGCTGGCCCTGGAGGAGGCTACCCTGAGTACCGATCTGCAGCAGGGTTATGCCCTTAAAAGTCTCACAGGCCTTCTCTCC
TCCTTTGTTGAGGTGGAATCCATCAAAAGACATTTTAAAAGTCGCTTGGTGGGTACTGTGCTGAATGGATACCTGTGCTTGCGGAAGCTG
GTGGTGCAGAGGACCAAGCTGATCGATGAGACGCAGGACATGCTGCTGGAGATGCTGGAGGACATGACCACAGGTACAGAATCAGAAACC
AAGGCCTTCATGGCTGTGTGCATTGAGACAGCCAAGCGCTACAATCTGGATGACTACCGGACCCCGGTGTTCATCTTCGAGAGGCTCTGC
AGCATCATTTATCCTGAGGAGAATGAAGTCACTGAGTTCTTTGTGACCCTGGAGAAGGATCCCCAACAAGAAGACTTCTTACAGGGCAGG
ATGCCTGGGAACCCGTATAGCAGCAATGAGCCAGGCATCGGGCCGCTGATGAGGGATATAAAGAACAAGATTTGCCAGGACTGTGACTTA
GTGGCCCTCCTGGAAGATGACAGTGGCATGGAGCTTCTAGTGAACAATAAAATCATTAGTTTGGACCTTCCTGTGGCTGAAGTTTACAAG
AAAGTCTGGTGTACCACGAATGAGGGAGAGCCCATGAGGATTGTTTATCGTATGCGGGGGCTGCTGGGCGATGCCACAGAGGAGTTCATT
GAGTCCCTGGACTCTACTACAGATGAAGAAGAAGATGAAGAAGAAGTGTATAAAATGGCTGGTGTGATGGCCCAGTGTGGGGGCCTGGAA
TGCATGCTTAACAGACTCGCAGGGATCAGAGATTTCAAGCAGGGACGCCACCTTCTAACAGTGCTACTGAAATTGTTCAGTTACTGCGTG
AAGGTGAAAGTCAACCGGCAGCAACTGGTCAAACTGGAAATGAACACCTTGAACGTCATGCTGGGGACCCTAAACCTGGCCCTTGTAGCT
GAACAAGAAAGCAAGGACAGTGGGGGTGCAGCTGTGGCTGAGCAGGTGCTTAGCATCATGGAGATCATTCTAGATGAGTCCAATGCTGAG
CCCCTGAGTGAGGACAAGGGCAACCTCCTCCTGACAGGTGACAAGGATCAACTGGTGATGCTCTTGGACCAGATCAACAGCACCTTTGTT
CGCTCCAACCCCAGTGTGCTCCAGGGCCTGCTTCGCATCATCCCGTACCTTTCCTTTGGAGAGGTGGAGAAAATGCAGATCTTGGTGGAG
CGATTCAAACCATACTGCAACTTTGATAAATATGATGAAGATCACAGTGGTGATGATAAAGTCTTCCTGGACTGCTTCTGTAAAATAGCT
GCTGGCATCAAGAACAACAGCAATGGGCACCAGCTGAAGGATCTGATTCTCCAGAAGGGGATCACCCAGAATGCACTTGACTACATGAAA
AAGCACATCCCTAGCGCCAAGAATTTGGATGCCGACATCTGGAAAAAGTTTTTGTCTCGCCCAGCCTTGCCATTTATCCTAAGGCTGCTT
CGGGGCCTGGCCATCCAGCACCCTGGCACCCAGGTTCTGATTGGAACTGATTCCATCCCGAACCTGCATAAGCTGGAGCAGGTGTCCAGT
GATGAGGGCATTGGGACCTTGGCAGAGAACCTGCTGGAAGCCCTGCGGGAACACCCTGACGTAAACAAGAAGATTGACGCAGCCCGCAGG
GAGACCCGGGCAGAGAAGAAGCGCATGGCCATGGCAATGAGGCAGAAGGCCCTGGGCACCCTGGGCATGACGACAAATGAAAAGGGCCAG
GTCGTGACCAAGACAGCACTCCTGAAGCAGATGGAAGAGCTGATCGAGGAGCCTGGCCTCACGTGCTGCATCTGCAGGGAGGGATACAAG
TTCCAGCCCACAAAGGTCCTGGGCATTTATACCTTCACGAAGCGGGTAGCCTTGGAGGAGATGGAGAATAAGCCCCGGAAACAGCAGGGC
TACAGCACCGTGTCCCACTTCAACATTGTGCACTACGACTGCCATCTGGCTGCCGTCAGGTTGGCTCGAGGCCGGGAAGAGTGGGAGAGT
GCCGCCCTGCAGAATGCCAACACCAAGTGCAACGGGCTCCTTCCGGTCTGGGGACCTCATGTCCCTGAATCAGCTTTTGCCACTTGCTTG
GCAAGACACAACACTTACCTCCAGGAATGTACAGGCCAGCGGGAGCCCACGTATCAGCTCAACATCCATGACATCAAACTGCTCTTCCTG
CGCTTCGCCATGGAGCAGTCGTTCAGCGCAGACACTGGCGGGGGCGGCCGGGAGAGCAACATCCACCTGATCCCGTACATCATTCACACT
GTGCTTTACGTCCTGAACACAACCCGAGCAACTTCCCGAGAAGAGAAGAACCTCCAAGGCTTTCTGGAACAGCCCAAGGAGAAGTGGGTG
GAGAGTGCCTTTGAAGTGGACGGGCCCTACTATTTCACAGTCTTGGCCCTTCACATCCTGCCCCCTGAGCAGTGGAGAGCCACACGTGTG
GAAATCTTGCGGAGGCTGTTGGTGACCTCGCAGGCTCGGGCAGTGGCTCCAGGTGGAGCCACCAGGCTGACAGATAAGGCAGTGAAGGAC
TATTCCGCTTACCGTTCTTCCCTTCTCTTTTGGGCCCTCGTCGATCTCATTTACAACATGTTTAAGAAGGTGCCTACCAGTAACACAGAG
GGAGGCTGGTCCTGCTCTCTCGCTGAGTACATCCGCCACAACGACATGCCCATCTACGAAGCTGCCGACAAAGCCCTGAAAACCTTCCAG
GAGGAGTTCATGCCAGTGGAGACCTTCTCAGAGTTCCTCGATGTGGCCGGTCTTTTATCAGAAATCACCGATCCAGAGAGCTTCCTGAAG
GACCTGTTGAACTCAGTCCCCTGACCACCACACAGCAGCTGCGGCGGCGAAGACGAAGCTGGCTTGCCTTCCACCCTCTGTTCTCCCTCC
TTGTGCATTAAGTTCCCTCCGCGGGATGCTGCATTGTTACCCCGCCCTCCCCTCTCTCATTTTTCTTGGTGTGGCTTGGGGTTTTTAGGC
TTCCTGTTTTATCTCGTGTGTGTGGTGCACCAGCTATGAGGTTGTCTGTAACCCAAGCCATCAAAGGGCCTGTACATACCTAGGAGCCAT

>2235_2235_1_ADCY3-UBR4_ADCY3_chr2_25043593_ENST00000260600_UBR4_chr1_19436958_ENST00000375217_length(amino acids)=2303AA_BP=1084
MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDC
YVVVMCAVVFSSDKLASLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFF
ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEE
QSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQ
LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGI
PGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHS
SGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEK
QSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMAN
VVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREH
DLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHV
ARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPD
VNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVM
GNIQASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCN
EIHAQAQLWLKRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHLYLTEKYVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQA
ARQAACTIVEALATIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYLAARGVLPYVGNLITKEIARLLALEEATLST
DLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRY
NLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLV
NNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQ
GRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGD
KDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKD
LILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQVSSDEGIGTLAENLLEA
LREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTK
RVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQR
EPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTV
LALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHN

--------------------------------------------------------------
>2235_2235_2_ADCY3-UBR4_ADCY3_chr2_25043593_ENST00000260600_UBR4_chr1_19436958_ENST00000375226_length(transcript)=8090nt_BP=4104nt
CGGGCCTGACGGCGGGAGATCGCGCTCCGGCCGGGCCCCGAGGCGCTGCCGGGGCGGCGCGGCTCTGCGGGGAGCAGCCCTCGGGCGCGC
CGAGCTCTCCCGCCCCAGCCCGCGCGGGGACCGTCCCGGAGCACGCGGTGGCCGAGTTCCCGCACAGGTAAACGCAGGGGCAGGGCCAGG
CTTCCGGGGGGGAAGACAGCGCCCCGAGCGTGGGAAGGGGGCCGGATCGGAGCCCGAGCCTCCAAGGGTTTGGTGGAAAAAGGAAGTAAA
CAGAAGGAAGGCTCAGGAATCCCCCACGATGGTCCTGATTTCTTTCCGGCACATTTTATTTACAGCTTCTAAGGACTGGGCCTGGAGGGA
ATTTAGGTGAGGAAGTCGGGGACTGAGAAAGAAGAGATGACAGAGAGAAACCGGTTACCAGGGATGGAAAGGCGGCTAGGCCCTTCCACA
AGCCAGGGACAGGAAATTGAGTGTCTGGCGTGGACAGGACTAAGTGTGCCTGCGGTGGGCGGTGGTGTGAGCCGGGGGTGGCAGGGAAGG
CCCTGGGTTGGGAGGCTCTTGCAGCAGAGATCCTTTTATGAGGGTTAGGGCGGGTCATGGGGAAACCGCAAGGTAGGAGGGAAGAGGTGC
TTCTACTCAGCAATGCCCTTTTCAGTTCTAGCTGATCAGTGCTACCTGTGCTCTGGAAACCCGCTCTGCGTTCCTGCTGGAGGTGGCCTC
CCCTCCGCCCCAGACAAGAAGAGGCCCTCAGCCCTCCCCCGGTCTCAGAGAGCCCTGAGAGGAGGCCCAGTCCAGAGCTCTTCCTCCGTT
CCCAGTCCACTTCTCTAGGGCCAGTAGCAGACACCAGCCAGTATGCCGAGGAACCAGGGCTTCTCCGAGCCCGAATACTCGGCCGAGTAC
TCAGCCGAGTACTCCGTCAGCCTGCCCTCCGACCCTGACCGCGGGGTGGGCCGGACCCATGAAATCTCGGTCCGGAACTCGGGCTCCTGC
CTGTGCCTGCCTCGCTTCATGCGGCTGACTTTCGTGCCGGAGTCCTTGGAGAACCTCTACCAGACCTACTTCAAAAGGCAGCGCCACGAG
ACCCTGCTGGTGCTGGTGGTCTTTGCAGCCCTCTTTGACTGCTACGTGGTGGTCATGTGTGCTGTGGTCTTCTCCAGCGACAAGCTGGCT
TCCCTCGCCGTGGCTGGAATTGGACTGGTGTTGGACATCATCCTCTTCGTGCTCTGCAAAAAGGGGCTGCTCCCGGACCGGGTCACCCGC
AGAGTGCTGCCCTACGTGCTGTGGCTGCTCATAACCGCCCAGATCTTCTCCTACCTGGGCCTGAACTTCGCGCGTGCCCACGCGGCTAGT
GACACGGTGGGCTGGCAGGTCTTCTTTGTCTTCTCCTTCTTCATCACGCTGCCCCTCAGCCTCAGCCCCATCGTGATCATCTCCGTGGTC
TCCTGTGTGGTGCACACGTTGGTCCTGGGGGTCACCGTGGCCCAGCAGCAGCAGGAGGAGCTCAAGGGGATGCAGCTGCTGCGGGAGATC
CTGGCCAACGTCTTCCTCTACCTGTGCGCCATCGCTGTGGGCATCATGTCCTACTACATGGCTGACCGCAAGCACCGCAAGGCCTTCCTG
GAGGCCCGCCAGTCGCTGGAGGTGAAGATGAACCTGGAAGAGCAGAGCCAGCAGCAGGAGAACCTCATGCTTTCCATCCTGCCCAAGCAC
GTGGCTGACGAGATGCTGAAAGACATGAAGAAAGACGAGAGCCAGAAGGACCAGCAGCAGTTCAACACCATGTACATGTACCGTCACGAG
AACGTCAGCATCCTCTTTGCCGACATCGTGGGCTTTACCCAGCTGTCTTCTGCCTGCAGTGCCCAGGAGCTTGTGAAGCTGCTCAACGAG
CTCTTTGCCCGCTTTGACAAGCTGGCAGCTAAATACCACCAGCTGCGGATTAAGATCCTGGGCGACTGCTACTACTGCATCTGCGGCTTG
CCCGACTACCGGGAGGACCACGCCGTCTGCTCCATCCTCATGGGGCTGGCCATGGTGGAGGCCATCTCGTATGTGCGGGAGAAGACCAAG
ACTGGGGTGGACATGCGTGTGGGGGTGCACACGGGCACCGTGCTGGGGGGCGTCCTGGGCCAGAAGCGCTGGCAGTACGACGTGTGGTCG
ACTGATGTCACTGTAGCCAACAAGATGGAGGCCGGCGGCATCCCTGGGCGCGTGCACATCTCCCAGAGCACCATGGACTGCCTGAAAGGG
GAGTTTGATGTGGAGCCAGGCGATGGGGGCAGCCGCTGTGATTACCTAGAAGAGAAGGGTATTGAAACCTACCTCATCATTGCCTCCAAG
CCAGAGGTGAAGAAAACAGCCACCCAGAATGGCCTCAATGGCTCGGCCCTGCCCAATGGAGCACCAGCTTCCTCAAAGTCCAGCTCCCCT
GCCCTCATTGAGACCAAGGAGCCCAACGGGAGTGCCCACAGCAGTGGGTCCACGTCGGAGAAGCCCGAGGAGCAGGATGCCCAGGCCGAC
AACCCCTCATTCCCCAACCCACGCCGGAGGCTGCGCCTGCAGGACCTGGCTGACCGAGTGGTGGATGCCTCTGAAGATGAGCACGAGCTC
AACCAGCTGCTCAACGAGGCCCTGCTTGAGCGAGAGTCCGCCCAAGTAGTAAAGAAGAGAAACACCTTCCTCTTGTCCATGCGGTTCATG
GACCCCGAGATGGAAACCCGCTACTCGGTGGAGAAGGAGAAGCAGAGTGGGGCTGCCTTCAGCTGCTCCTGCGTCGTCCTGCTCTGCACG
GCCCTGGTCGAGATACTCATCGACCCCTGGCTAATGACAAACTATGTGACCTTCATGGTGGGGGAGATTCTGCTCCTCATCCTGACCATC
TGCTCCCTGGCTGCCATCTTTCCCCGGGCCTTTCCTAAGAAGCTTGTGGCCTTCTCAACTTGGATTGACCGGACCCGCTGGGCCAGGAAC
ACCTGGGCCATGCTCGCCATCTTCATCCTGGTGATGGCAAATGTCGTGGACATGCTCAGCTGTCTCCAGTACTACACGGGACCCAGCAAT
GCAACGGCAGGGATGGAAACGGAGGGCAGCTGCCTGGAGAACCCCAAGTATTACAACTATGTGGCCGTGCTGTCCCTCATCGCCACCATC
ATGCTGGTGCAGGTCAGCCACATGGTGAAGCTCACGCTCATGCTGCTCGTCGCAGGCGCCGTGGCCACCATCAACCTCTATGCCTGGCGT
CCCGTCTTTGATGAATACGACCACAAGCGTTTTCGGGAGCACGACTTACCTATGGTGGCCTTAGAGCAGATGCAAGGATTCAACCCTGGG
CTCAATGGCACTGACAGGCTGCCCCTGGTGCCTTCCAAGTACTCTATGACGGTGATGGTGTTCCTCATGATGCTCAGCTTCTACTACTTC
TCCCGCCACGTAGAAAAACTGGCACGGACACTTTTCTTGTGGAAGATTGAGGTCCACGACCAGAAGGAACGTGTCTATGAGATGCGACGC
TGGAACGAGGCCTTGGTCACCAACATGTTGCCTGAGCACGTGGCACGCCATTTCCTGGGGTCCAAGAAGAGAGATGAGGAGCTGTATAGC
CAGACGTATGATGAGATTGGAGTCATGTTTGCCTCCCTGCCCAACTTTGCTGACTTCTACACAGAGGAGAGCATCAACAATGGTGGTATT
GAGTGTCTGCGTTTCCTCAATGAAATCATCTCAGATTTTGACTCTCTCCTGGACAATCCCAAGTTCCGGGTGATCACCAAGATCAAAACC
ATTGGCAGCACGTATATGGCGGCTTCAGGAGTCACCCCCGATGTCAACACCAATGGCTTTGCCAGCTCCAACAAGGAAGACAAGTCCGAG
AGAGAGCGCTGGCAGCACCTGGCTGACCTGGCCGACTTCGCGCTGGCCATGAAGGATACGCTCACCAACATCAACAACCAGTCCTTCAAT
AACTTCATGCTGCGCATAGGCATGAACAAAGGCGGGGTTCTGGCTGGGGTCATCGGAGCCCGGAAACCACACTACGACATCTGGGGCAAT
ACAGTCAATGTAGCCAGCAGGATGGAGTCCACGGGGGTCATGGGCAACATTCAGGCAAGTAGCCTGCAGTATGAAATGCTGCTGCTGACG
GATTCTATCTCCAAGGAGGACAGCTGCTGGGAGCTCCGGTTACGCTGTGCTCTCAGCCTTTTCCTCATGGCTGTGAACATTAAGACTCCT
GTGGTGGTTGAAAACATTACCCTCATGTGCCTGAGGATCTTGCAGAAGCTGATAAAACCACCTGCTCCCACTAGCAAGAAGAACAAGGAT
GTCCCCGTTGAGGCCCTCACCACGGTGAAGCCATACTGCAATGAGATCCATGCCCAGGCTCAACTGTGGCTCAAGAGAGACCCCAAGGCA
TCCTATGATGCCTGGAAGAAGTGTCTTCCTATCAGAGGGATAGATGGCAATGGGAAAGCCCCCAGCAAATCAGAGCTCCGCCATCTCTAT
TTGACTGAGAAGTATGTGTGGAGGTGGAAACAGTTCCTGAGTCGTCGGGGGAAGAGGACCTCCCCCTTGGATCTCAAACTGGGGCATAAC
AACTGGCTGCGACAAGTGCTTTTCACTCCAGCAACGCAGGCCGCACGGCAGGCAGCCTGTACCATTGTGGAAGCTCTAGCCACCATTCCC
AGCCGCAAGCAGCAGGTCCTGGACCTGCTTACCAGTTACCTGGATGAGCTGAGCATAGCTGGGGAGTGTGCAGCTGAGTACCTGGCTCTC
TACCAGAAGCTCATCACTTCTGCGCACTGGAAAGTCTACTTGGCAGCTCGGGGAGTCCTACCCTATGTGGGCAACCTCATCACCAAGGAA
ATAGCTCGTCTGCTGGCCCTGGAGGAGGCTACCCTGAGTACCGATCTGCAGCAGGGTTATGCCCTTAAAAGTCTCACAGGCCTTCTCTCC
TCCTTTGTTGAGGTGGAATCCATCAAAAGACATTTTAAAAGTCGCTTGGTGGGTACTGTGCTGAATGGATACCTGTGCTTGCGGAAGCTG
GTGGTGCAGAGGACCAAGCTGATCGATGAGACGCAGGACATGCTGCTGGAGATGCTGGAGGACATGACCACAGGTACAGAATCAGAAACC
AAGGCCTTCATGGCTGTGTGCATTGAGACAGCCAAGCGCTACAATCTGGATGACTACCGGACCCCGGTGTTCATCTTCGAGAGGCTCTGC
AGCATCATTTATCCTGAGGAGAATGAAGTCACTGAGTTCTTTGTGACCCTGGAGAAGGATCCCCAACAAGAAGACTTCTTACAGGGCAGG
ATGCCTGGGAACCCGTATAGCAGCAATGAGCCAGGCATCGGGCCGCTGATGAGGGATATAAAGAACAAGATTTGCCAGGACTGTGACTTA
GTGGCCCTCCTGGAAGATGACAGTGGCATGGAGCTTCTAGTGAACAATAAAATCATTAGTTTGGACCTTCCTGTGGCTGAAGTTTACAAG
AAAGTCTGGTGTACCACGAATGAGGGAGAGCCCATGAGGATTGTTTATCGTATGCGGGGGCTGCTGGGCGATGCCACAGAGGAGTTCATT
GAGTCCCTGGACTCTACTACAGATGAAGAAGAAGATGAAGAAGAAGTGTATAAAATGGCTGGTGTGATGGCCCAGTGTGGGGGCCTGGAA
TGCATGCTTAACAGACTCGCAGGGATCAGAGATTTCAAGCAGGGACGCCACCTTCTAACAGTGCTACTGAAATTGTTCAGTTACTGCGTG
AAGGTGAAAGTCAACCGGCAGCAACTGGTCAAACTGGAAATGAACACCTTGAACGTCATGCTGGGGACCCTAAACCTGGCCCTTGTAGCT
GAACAAGAAAGCAAGGACAGTGGGGGTGCAGCTGTGGCTGAGCAGGTGCTTAGCATCATGGAGATCATTCTAGATGAGTCCAATGCTGAG
CCCCTGAGTGAGGACAAGGGCAACCTCCTCCTGACAGGTGACAAGGATCAACTGGTGATGCTCTTGGACCAGATCAACAGCACCTTTGTT
CGCTCCAACCCCAGTGTGCTCCAGGGCCTGCTTCGCATCATCCCGTACCTTTCCTTTGGAGAGGTGGAGAAAATGCAGATCTTGGTGGAG
CGATTCAAACCATACTGCAACTTTGATAAATATGATGAAGATCACAGTGGTGATGATAAAGTCTTCCTGGACTGCTTCTGTAAAATAGCT
GCTGGCATCAAGAACAACAGCAATGGGCACCAGCTGAAGGATCTGATTCTCCAGAAGGGGATCACCCAGAATGCACTTGACTACATGAAA
AAGCACATCCCTAGCGCCAAGAATTTGGATGCCGACATCTGGAAAAAGTTTTTGTCTCGCCCAGCCTTGCCATTTATCCTAAGGCTGCTT
CGGGGCCTGGCCATCCAGCACCCTGGCACCCAGGTTCTGATTGGAACTGATTCCATCCCGAACCTGCATAAGCTGGAGCAGGTGTCCAGT
GATGAGGGCATTGGGACCTTGGCAGAGAACCTGCTGGAAGCCCTGCGGGAACACCCTGACGTAAACAAGAAGATTGACGCAGCCCGCAGG
GAGACCCGGGCAGAGAAGAAGCGCATGGCCATGGCAATGAGGCAGAAGGCCCTGGGCACCCTGGGCATGACGACAAATGAAAAGGGCCAG
GTCGTGACCAAGACAGCACTCCTGAAGCAGATGGAAGAGCTGATCGAGGAGCCTGGCCTCACGTGCTGCATCTGCAGGGAGGGATACAAG
TTCCAGCCCACAAAGGTCCTGGGCATTTATACCTTCACGAAGCGGGTAGCCTTGGAGGAGATGGAGAATAAGCCCCGGAAACAGCAGGGC
TACAGCACCGTGTCCCACTTCAACATTGTGCACTACGACTGCCATCTGGCTGCCGTCAGGTTGGCTCGAGGCCGGGAAGAGTGGGAGAGT
GCCGCCCTGCAGAATGCCAACACCAAGTGCAACGGGCTCCTTCCGGTCTGGGGACCTCATGTCCCTGAATCAGCTTTTGCCACTTGCTTG
GCAAGACACAACACTTACCTCCAGGAATGTACAGGCCAGCGGGAGCCCACGTATCAGCTCAACATCCATGACATCAAACTGCTCTTCCTG
CGCTTCGCCATGGAGCAGTCGTTCAGCGCAGACACTGGCGGGGGCGGCCGGGAGAGCAACATCCACCTGATCCCGTACATCATTCACACT
GTGCTTTACGTCCTGAACACAACCCGAGCAACTTCCCGAGAAGAGAAGAACCTCCAAGGCTTTCTGGAACAGCCCAAGGAGAAGTGGGTG
GAGAGTGCCTTTGAAGTGGACGGGCCCTACTATTTCACAGTCTTGGCCCTTCACATCCTGCCCCCTGAGCAGTGGAGAGCCACACGTGTG
GAAATCTTGCGGAGGCTGTTGGTGACCTCGCAGGCTCGGGCAGTGGCTCCAGGTGGAGCCACCAGGCTGACAGATAAGGCAGTGAAGGAC
TATTCCGCTTACCGTTCTTCCCTTCTCTTTTGGGCCCTCGTCGATCTCATTTACAACATGTTTAAGAAGGTGCCTACCAGTAACACAGAG
GGAGGCTGGTCCTGCTCTCTCGCTGAGTACATCCGCCACAACGACATGCCCATCTACGAAGCTGCCGACAAAGCCCTGAAAACCTTCCAG
GAGGAGTTCATGCCAGTGGAGACCTTCTCAGAGTTCCTCGATGTGGCCGGTCTTTTATCAGAAATCACCGATCCAGAGAGCTTCCTGAAG
GACCTGTTGAACTCAGTCCCCTGACCACCACACAGCAGCTGCGGCGGCGAAGACGAAGCTGGCTTGCCTTCCACCCTCTGTTCTCCCTCC
TTGTGCATTAAGTTCCCTCCGCGGGATGCTGCATTGTTACCCCGCCCTCCCCTCTCTCATTTTTCTTGGTGTGGCTTGGGGTTTTTAGGC
TTCCTGTTTTATCTCGTGTGTGTGGTGCACCAGCTATGAGGTTGTCTGTAACCCAAGCCATCAAAGGGCCTGTACATACCTAGGAGCCAT

>2235_2235_2_ADCY3-UBR4_ADCY3_chr2_25043593_ENST00000260600_UBR4_chr1_19436958_ENST00000375226_length(amino acids)=2303AA_BP=1084
MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDC
YVVVMCAVVFSSDKLASLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFF
ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEE
QSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQ
LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGI
PGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHS
SGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEK
QSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMAN
VVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREH
DLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHV
ARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPD
VNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVM
GNIQASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCN
EIHAQAQLWLKRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHLYLTEKYVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQA
ARQAACTIVEALATIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYLAARGVLPYVGNLITKEIARLLALEEATLST
DLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRY
NLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLV
NNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQ
GRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGD
KDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKD
LILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQVSSDEGIGTLAENLLEA
LREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTK
RVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQR
EPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTV
LALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHN

--------------------------------------------------------------
>2235_2235_3_ADCY3-UBR4_ADCY3_chr2_25043593_ENST00000260600_UBR4_chr1_19436958_ENST00000375254_length(transcript)=8090nt_BP=4104nt
CGGGCCTGACGGCGGGAGATCGCGCTCCGGCCGGGCCCCGAGGCGCTGCCGGGGCGGCGCGGCTCTGCGGGGAGCAGCCCTCGGGCGCGC
CGAGCTCTCCCGCCCCAGCCCGCGCGGGGACCGTCCCGGAGCACGCGGTGGCCGAGTTCCCGCACAGGTAAACGCAGGGGCAGGGCCAGG
CTTCCGGGGGGGAAGACAGCGCCCCGAGCGTGGGAAGGGGGCCGGATCGGAGCCCGAGCCTCCAAGGGTTTGGTGGAAAAAGGAAGTAAA
CAGAAGGAAGGCTCAGGAATCCCCCACGATGGTCCTGATTTCTTTCCGGCACATTTTATTTACAGCTTCTAAGGACTGGGCCTGGAGGGA
ATTTAGGTGAGGAAGTCGGGGACTGAGAAAGAAGAGATGACAGAGAGAAACCGGTTACCAGGGATGGAAAGGCGGCTAGGCCCTTCCACA
AGCCAGGGACAGGAAATTGAGTGTCTGGCGTGGACAGGACTAAGTGTGCCTGCGGTGGGCGGTGGTGTGAGCCGGGGGTGGCAGGGAAGG
CCCTGGGTTGGGAGGCTCTTGCAGCAGAGATCCTTTTATGAGGGTTAGGGCGGGTCATGGGGAAACCGCAAGGTAGGAGGGAAGAGGTGC
TTCTACTCAGCAATGCCCTTTTCAGTTCTAGCTGATCAGTGCTACCTGTGCTCTGGAAACCCGCTCTGCGTTCCTGCTGGAGGTGGCCTC
CCCTCCGCCCCAGACAAGAAGAGGCCCTCAGCCCTCCCCCGGTCTCAGAGAGCCCTGAGAGGAGGCCCAGTCCAGAGCTCTTCCTCCGTT
CCCAGTCCACTTCTCTAGGGCCAGTAGCAGACACCAGCCAGTATGCCGAGGAACCAGGGCTTCTCCGAGCCCGAATACTCGGCCGAGTAC
TCAGCCGAGTACTCCGTCAGCCTGCCCTCCGACCCTGACCGCGGGGTGGGCCGGACCCATGAAATCTCGGTCCGGAACTCGGGCTCCTGC
CTGTGCCTGCCTCGCTTCATGCGGCTGACTTTCGTGCCGGAGTCCTTGGAGAACCTCTACCAGACCTACTTCAAAAGGCAGCGCCACGAG
ACCCTGCTGGTGCTGGTGGTCTTTGCAGCCCTCTTTGACTGCTACGTGGTGGTCATGTGTGCTGTGGTCTTCTCCAGCGACAAGCTGGCT
TCCCTCGCCGTGGCTGGAATTGGACTGGTGTTGGACATCATCCTCTTCGTGCTCTGCAAAAAGGGGCTGCTCCCGGACCGGGTCACCCGC
AGAGTGCTGCCCTACGTGCTGTGGCTGCTCATAACCGCCCAGATCTTCTCCTACCTGGGCCTGAACTTCGCGCGTGCCCACGCGGCTAGT
GACACGGTGGGCTGGCAGGTCTTCTTTGTCTTCTCCTTCTTCATCACGCTGCCCCTCAGCCTCAGCCCCATCGTGATCATCTCCGTGGTC
TCCTGTGTGGTGCACACGTTGGTCCTGGGGGTCACCGTGGCCCAGCAGCAGCAGGAGGAGCTCAAGGGGATGCAGCTGCTGCGGGAGATC
CTGGCCAACGTCTTCCTCTACCTGTGCGCCATCGCTGTGGGCATCATGTCCTACTACATGGCTGACCGCAAGCACCGCAAGGCCTTCCTG
GAGGCCCGCCAGTCGCTGGAGGTGAAGATGAACCTGGAAGAGCAGAGCCAGCAGCAGGAGAACCTCATGCTTTCCATCCTGCCCAAGCAC
GTGGCTGACGAGATGCTGAAAGACATGAAGAAAGACGAGAGCCAGAAGGACCAGCAGCAGTTCAACACCATGTACATGTACCGTCACGAG
AACGTCAGCATCCTCTTTGCCGACATCGTGGGCTTTACCCAGCTGTCTTCTGCCTGCAGTGCCCAGGAGCTTGTGAAGCTGCTCAACGAG
CTCTTTGCCCGCTTTGACAAGCTGGCAGCTAAATACCACCAGCTGCGGATTAAGATCCTGGGCGACTGCTACTACTGCATCTGCGGCTTG
CCCGACTACCGGGAGGACCACGCCGTCTGCTCCATCCTCATGGGGCTGGCCATGGTGGAGGCCATCTCGTATGTGCGGGAGAAGACCAAG
ACTGGGGTGGACATGCGTGTGGGGGTGCACACGGGCACCGTGCTGGGGGGCGTCCTGGGCCAGAAGCGCTGGCAGTACGACGTGTGGTCG
ACTGATGTCACTGTAGCCAACAAGATGGAGGCCGGCGGCATCCCTGGGCGCGTGCACATCTCCCAGAGCACCATGGACTGCCTGAAAGGG
GAGTTTGATGTGGAGCCAGGCGATGGGGGCAGCCGCTGTGATTACCTAGAAGAGAAGGGTATTGAAACCTACCTCATCATTGCCTCCAAG
CCAGAGGTGAAGAAAACAGCCACCCAGAATGGCCTCAATGGCTCGGCCCTGCCCAATGGAGCACCAGCTTCCTCAAAGTCCAGCTCCCCT
GCCCTCATTGAGACCAAGGAGCCCAACGGGAGTGCCCACAGCAGTGGGTCCACGTCGGAGAAGCCCGAGGAGCAGGATGCCCAGGCCGAC
AACCCCTCATTCCCCAACCCACGCCGGAGGCTGCGCCTGCAGGACCTGGCTGACCGAGTGGTGGATGCCTCTGAAGATGAGCACGAGCTC
AACCAGCTGCTCAACGAGGCCCTGCTTGAGCGAGAGTCCGCCCAAGTAGTAAAGAAGAGAAACACCTTCCTCTTGTCCATGCGGTTCATG
GACCCCGAGATGGAAACCCGCTACTCGGTGGAGAAGGAGAAGCAGAGTGGGGCTGCCTTCAGCTGCTCCTGCGTCGTCCTGCTCTGCACG
GCCCTGGTCGAGATACTCATCGACCCCTGGCTAATGACAAACTATGTGACCTTCATGGTGGGGGAGATTCTGCTCCTCATCCTGACCATC
TGCTCCCTGGCTGCCATCTTTCCCCGGGCCTTTCCTAAGAAGCTTGTGGCCTTCTCAACTTGGATTGACCGGACCCGCTGGGCCAGGAAC
ACCTGGGCCATGCTCGCCATCTTCATCCTGGTGATGGCAAATGTCGTGGACATGCTCAGCTGTCTCCAGTACTACACGGGACCCAGCAAT
GCAACGGCAGGGATGGAAACGGAGGGCAGCTGCCTGGAGAACCCCAAGTATTACAACTATGTGGCCGTGCTGTCCCTCATCGCCACCATC
ATGCTGGTGCAGGTCAGCCACATGGTGAAGCTCACGCTCATGCTGCTCGTCGCAGGCGCCGTGGCCACCATCAACCTCTATGCCTGGCGT
CCCGTCTTTGATGAATACGACCACAAGCGTTTTCGGGAGCACGACTTACCTATGGTGGCCTTAGAGCAGATGCAAGGATTCAACCCTGGG
CTCAATGGCACTGACAGGCTGCCCCTGGTGCCTTCCAAGTACTCTATGACGGTGATGGTGTTCCTCATGATGCTCAGCTTCTACTACTTC
TCCCGCCACGTAGAAAAACTGGCACGGACACTTTTCTTGTGGAAGATTGAGGTCCACGACCAGAAGGAACGTGTCTATGAGATGCGACGC
TGGAACGAGGCCTTGGTCACCAACATGTTGCCTGAGCACGTGGCACGCCATTTCCTGGGGTCCAAGAAGAGAGATGAGGAGCTGTATAGC
CAGACGTATGATGAGATTGGAGTCATGTTTGCCTCCCTGCCCAACTTTGCTGACTTCTACACAGAGGAGAGCATCAACAATGGTGGTATT
GAGTGTCTGCGTTTCCTCAATGAAATCATCTCAGATTTTGACTCTCTCCTGGACAATCCCAAGTTCCGGGTGATCACCAAGATCAAAACC
ATTGGCAGCACGTATATGGCGGCTTCAGGAGTCACCCCCGATGTCAACACCAATGGCTTTGCCAGCTCCAACAAGGAAGACAAGTCCGAG
AGAGAGCGCTGGCAGCACCTGGCTGACCTGGCCGACTTCGCGCTGGCCATGAAGGATACGCTCACCAACATCAACAACCAGTCCTTCAAT
AACTTCATGCTGCGCATAGGCATGAACAAAGGCGGGGTTCTGGCTGGGGTCATCGGAGCCCGGAAACCACACTACGACATCTGGGGCAAT
ACAGTCAATGTAGCCAGCAGGATGGAGTCCACGGGGGTCATGGGCAACATTCAGGCAAGTAGCCTGCAGTATGAAATGCTGCTGCTGACG
GATTCTATCTCCAAGGAGGACAGCTGCTGGGAGCTCCGGTTACGCTGTGCTCTCAGCCTTTTCCTCATGGCTGTGAACATTAAGACTCCT
GTGGTGGTTGAAAACATTACCCTCATGTGCCTGAGGATCTTGCAGAAGCTGATAAAACCACCTGCTCCCACTAGCAAGAAGAACAAGGAT
GTCCCCGTTGAGGCCCTCACCACGGTGAAGCCATACTGCAATGAGATCCATGCCCAGGCTCAACTGTGGCTCAAGAGAGACCCCAAGGCA
TCCTATGATGCCTGGAAGAAGTGTCTTCCTATCAGAGGGATAGATGGCAATGGGAAAGCCCCCAGCAAATCAGAGCTCCGCCATCTCTAT
TTGACTGAGAAGTATGTGTGGAGGTGGAAACAGTTCCTGAGTCGTCGGGGGAAGAGGACCTCCCCCTTGGATCTCAAACTGGGGCATAAC
AACTGGCTGCGACAAGTGCTTTTCACTCCAGCAACGCAGGCCGCACGGCAGGCAGCCTGTACCATTGTGGAAGCTCTAGCCACCATTCCC
AGCCGCAAGCAGCAGGTCCTGGACCTGCTTACCAGTTACCTGGATGAGCTGAGCATAGCTGGGGAGTGTGCAGCTGAGTACCTGGCTCTC
TACCAGAAGCTCATCACTTCTGCGCACTGGAAAGTCTACTTGGCAGCTCGGGGAGTCCTACCCTATGTGGGCAACCTCATCACCAAGGAA
ATAGCTCGTCTGCTGGCCCTGGAGGAGGCTACCCTGAGTACCGATCTGCAGCAGGGTTATGCCCTTAAAAGTCTCACAGGCCTTCTCTCC
TCCTTTGTTGAGGTGGAATCCATCAAAAGACATTTTAAAAGTCGCTTGGTGGGTACTGTGCTGAATGGATACCTGTGCTTGCGGAAGCTG
GTGGTGCAGAGGACCAAGCTGATCGATGAGACGCAGGACATGCTGCTGGAGATGCTGGAGGACATGACCACAGGTACAGAATCAGAAACC
AAGGCCTTCATGGCTGTGTGCATTGAGACAGCCAAGCGCTACAATCTGGATGACTACCGGACCCCGGTGTTCATCTTCGAGAGGCTCTGC
AGCATCATTTATCCTGAGGAGAATGAAGTCACTGAGTTCTTTGTGACCCTGGAGAAGGATCCCCAACAAGAAGACTTCTTACAGGGCAGG
ATGCCTGGGAACCCGTATAGCAGCAATGAGCCAGGCATCGGGCCGCTGATGAGGGATATAAAGAACAAGATTTGCCAGGACTGTGACTTA
GTGGCCCTCCTGGAAGATGACAGTGGCATGGAGCTTCTAGTGAACAATAAAATCATTAGTTTGGACCTTCCTGTGGCTGAAGTTTACAAG
AAAGTCTGGTGTACCACGAATGAGGGAGAGCCCATGAGGATTGTTTATCGTATGCGGGGGCTGCTGGGCGATGCCACAGAGGAGTTCATT
GAGTCCCTGGACTCTACTACAGATGAAGAAGAAGATGAAGAAGAAGTGTATAAAATGGCTGGTGTGATGGCCCAGTGTGGGGGCCTGGAA
TGCATGCTTAACAGACTCGCAGGGATCAGAGATTTCAAGCAGGGACGCCACCTTCTAACAGTGCTACTGAAATTGTTCAGTTACTGCGTG
AAGGTGAAAGTCAACCGGCAGCAACTGGTCAAACTGGAAATGAACACCTTGAACGTCATGCTGGGGACCCTAAACCTGGCCCTTGTAGCT
GAACAAGAAAGCAAGGACAGTGGGGGTGCAGCTGTGGCTGAGCAGGTGCTTAGCATCATGGAGATCATTCTAGATGAGTCCAATGCTGAG
CCCCTGAGTGAGGACAAGGGCAACCTCCTCCTGACAGGTGACAAGGATCAACTGGTGATGCTCTTGGACCAGATCAACAGCACCTTTGTT
CGCTCCAACCCCAGTGTGCTCCAGGGCCTGCTTCGCATCATCCCGTACCTTTCCTTTGGAGAGGTGGAGAAAATGCAGATCTTGGTGGAG
CGATTCAAACCATACTGCAACTTTGATAAATATGATGAAGATCACAGTGGTGATGATAAAGTCTTCCTGGACTGCTTCTGTAAAATAGCT
GCTGGCATCAAGAACAACAGCAATGGGCACCAGCTGAAGGATCTGATTCTCCAGAAGGGGATCACCCAGAATGCACTTGACTACATGAAA
AAGCACATCCCTAGCGCCAAGAATTTGGATGCCGACATCTGGAAAAAGTTTTTGTCTCGCCCAGCCTTGCCATTTATCCTAAGGCTGCTT
CGGGGCCTGGCCATCCAGCACCCTGGCACCCAGGTTCTGATTGGAACTGATTCCATCCCGAACCTGCATAAGCTGGAGCAGGTGTCCAGT
GATGAGGGCATTGGGACCTTGGCAGAGAACCTGCTGGAAGCCCTGCGGGAACACCCTGACGTAAACAAGAAGATTGACGCAGCCCGCAGG
GAGACCCGGGCAGAGAAGAAGCGCATGGCCATGGCAATGAGGCAGAAGGCCCTGGGCACCCTGGGCATGACGACAAATGAAAAGGGCCAG
GTCGTGACCAAGACAGCACTCCTGAAGCAGATGGAAGAGCTGATCGAGGAGCCTGGCCTCACGTGCTGCATCTGCAGGGAGGGATACAAG
TTCCAGCCCACAAAGGTCCTGGGCATTTATACCTTCACGAAGCGGGTAGCCTTGGAGGAGATGGAGAATAAGCCCCGGAAACAGCAGGGC
TACAGCACCGTGTCCCACTTCAACATTGTGCACTACGACTGCCATCTGGCTGCCGTCAGGTTGGCTCGAGGCCGGGAAGAGTGGGAGAGT
GCCGCCCTGCAGAATGCCAACACCAAGTGCAACGGGCTCCTTCCGGTCTGGGGACCTCATGTCCCTGAATCAGCTTTTGCCACTTGCTTG
GCAAGACACAACACTTACCTCCAGGAATGTACAGGCCAGCGGGAGCCCACGTATCAGCTCAACATCCATGACATCAAACTGCTCTTCCTG
CGCTTCGCCATGGAGCAGTCGTTCAGCGCAGACACTGGCGGGGGCGGCCGGGAGAGCAACATCCACCTGATCCCGTACATCATTCACACT
GTGCTTTACGTCCTGAACACAACCCGAGCAACTTCCCGAGAAGAGAAGAACCTCCAAGGCTTTCTGGAACAGCCCAAGGAGAAGTGGGTG
GAGAGTGCCTTTGAAGTGGACGGGCCCTACTATTTCACAGTCTTGGCCCTTCACATCCTGCCCCCTGAGCAGTGGAGAGCCACACGTGTG
GAAATCTTGCGGAGGCTGTTGGTGACCTCGCAGGCTCGGGCAGTGGCTCCAGGTGGAGCCACCAGGCTGACAGATAAGGCAGTGAAGGAC
TATTCCGCTTACCGTTCTTCCCTTCTCTTTTGGGCCCTCGTCGATCTCATTTACAACATGTTTAAGAAGGTGCCTACCAGTAACACAGAG
GGAGGCTGGTCCTGCTCTCTCGCTGAGTACATCCGCCACAACGACATGCCCATCTACGAAGCTGCCGACAAAGCCCTGAAAACCTTCCAG
GAGGAGTTCATGCCAGTGGAGACCTTCTCAGAGTTCCTCGATGTGGCCGGTCTTTTATCAGAAATCACCGATCCAGAGAGCTTCCTGAAG
GACCTGTTGAACTCAGTCCCCTGACCACCACACAGCAGCTGCGGCGGCGAAGACGAAGCTGGCTTGCCTTCCACCCTCTGTTCTCCCTCC
TTGTGCATTAAGTTCCCTCCGCGGGATGCTGCATTGTTACCCCGCCCTCCCCTCTCTCATTTTTCTTGGTGTGGCTTGGGGTTTTTAGGC
TTCCTGTTTTATCTCGTGTGTGTGGTGCACCAGCTATGAGGTTGTCTGTAACCCAAGCCATCAAAGGGCCTGTACATACCTAGGAGCCAT

>2235_2235_3_ADCY3-UBR4_ADCY3_chr2_25043593_ENST00000260600_UBR4_chr1_19436958_ENST00000375254_length(amino acids)=2303AA_BP=1084
MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDC
YVVVMCAVVFSSDKLASLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFF
ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEE
QSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQ
LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGI
PGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHS
SGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEK
QSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMAN
VVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREH
DLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHV
ARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPD
VNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVM
GNIQASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCN
EIHAQAQLWLKRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHLYLTEKYVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQA
ARQAACTIVEALATIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYLAARGVLPYVGNLITKEIARLLALEEATLST
DLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRY
NLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLV
NNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQ
GRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGD
KDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKD
LILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQVSSDEGIGTLAENLLEA
LREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTK
RVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQR
EPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTV
LALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHN

--------------------------------------------------------------
>2235_2235_4_ADCY3-UBR4_ADCY3_chr2_25043593_ENST00000260600_UBR4_chr1_19436958_ENST00000375267_length(transcript)=8153nt_BP=4104nt
CGGGCCTGACGGCGGGAGATCGCGCTCCGGCCGGGCCCCGAGGCGCTGCCGGGGCGGCGCGGCTCTGCGGGGAGCAGCCCTCGGGCGCGC
CGAGCTCTCCCGCCCCAGCCCGCGCGGGGACCGTCCCGGAGCACGCGGTGGCCGAGTTCCCGCACAGGTAAACGCAGGGGCAGGGCCAGG
CTTCCGGGGGGGAAGACAGCGCCCCGAGCGTGGGAAGGGGGCCGGATCGGAGCCCGAGCCTCCAAGGGTTTGGTGGAAAAAGGAAGTAAA
CAGAAGGAAGGCTCAGGAATCCCCCACGATGGTCCTGATTTCTTTCCGGCACATTTTATTTACAGCTTCTAAGGACTGGGCCTGGAGGGA
ATTTAGGTGAGGAAGTCGGGGACTGAGAAAGAAGAGATGACAGAGAGAAACCGGTTACCAGGGATGGAAAGGCGGCTAGGCCCTTCCACA
AGCCAGGGACAGGAAATTGAGTGTCTGGCGTGGACAGGACTAAGTGTGCCTGCGGTGGGCGGTGGTGTGAGCCGGGGGTGGCAGGGAAGG
CCCTGGGTTGGGAGGCTCTTGCAGCAGAGATCCTTTTATGAGGGTTAGGGCGGGTCATGGGGAAACCGCAAGGTAGGAGGGAAGAGGTGC
TTCTACTCAGCAATGCCCTTTTCAGTTCTAGCTGATCAGTGCTACCTGTGCTCTGGAAACCCGCTCTGCGTTCCTGCTGGAGGTGGCCTC
CCCTCCGCCCCAGACAAGAAGAGGCCCTCAGCCCTCCCCCGGTCTCAGAGAGCCCTGAGAGGAGGCCCAGTCCAGAGCTCTTCCTCCGTT
CCCAGTCCACTTCTCTAGGGCCAGTAGCAGACACCAGCCAGTATGCCGAGGAACCAGGGCTTCTCCGAGCCCGAATACTCGGCCGAGTAC
TCAGCCGAGTACTCCGTCAGCCTGCCCTCCGACCCTGACCGCGGGGTGGGCCGGACCCATGAAATCTCGGTCCGGAACTCGGGCTCCTGC
CTGTGCCTGCCTCGCTTCATGCGGCTGACTTTCGTGCCGGAGTCCTTGGAGAACCTCTACCAGACCTACTTCAAAAGGCAGCGCCACGAG
ACCCTGCTGGTGCTGGTGGTCTTTGCAGCCCTCTTTGACTGCTACGTGGTGGTCATGTGTGCTGTGGTCTTCTCCAGCGACAAGCTGGCT
TCCCTCGCCGTGGCTGGAATTGGACTGGTGTTGGACATCATCCTCTTCGTGCTCTGCAAAAAGGGGCTGCTCCCGGACCGGGTCACCCGC
AGAGTGCTGCCCTACGTGCTGTGGCTGCTCATAACCGCCCAGATCTTCTCCTACCTGGGCCTGAACTTCGCGCGTGCCCACGCGGCTAGT
GACACGGTGGGCTGGCAGGTCTTCTTTGTCTTCTCCTTCTTCATCACGCTGCCCCTCAGCCTCAGCCCCATCGTGATCATCTCCGTGGTC
TCCTGTGTGGTGCACACGTTGGTCCTGGGGGTCACCGTGGCCCAGCAGCAGCAGGAGGAGCTCAAGGGGATGCAGCTGCTGCGGGAGATC
CTGGCCAACGTCTTCCTCTACCTGTGCGCCATCGCTGTGGGCATCATGTCCTACTACATGGCTGACCGCAAGCACCGCAAGGCCTTCCTG
GAGGCCCGCCAGTCGCTGGAGGTGAAGATGAACCTGGAAGAGCAGAGCCAGCAGCAGGAGAACCTCATGCTTTCCATCCTGCCCAAGCAC
GTGGCTGACGAGATGCTGAAAGACATGAAGAAAGACGAGAGCCAGAAGGACCAGCAGCAGTTCAACACCATGTACATGTACCGTCACGAG
AACGTCAGCATCCTCTTTGCCGACATCGTGGGCTTTACCCAGCTGTCTTCTGCCTGCAGTGCCCAGGAGCTTGTGAAGCTGCTCAACGAG
CTCTTTGCCCGCTTTGACAAGCTGGCAGCTAAATACCACCAGCTGCGGATTAAGATCCTGGGCGACTGCTACTACTGCATCTGCGGCTTG
CCCGACTACCGGGAGGACCACGCCGTCTGCTCCATCCTCATGGGGCTGGCCATGGTGGAGGCCATCTCGTATGTGCGGGAGAAGACCAAG
ACTGGGGTGGACATGCGTGTGGGGGTGCACACGGGCACCGTGCTGGGGGGCGTCCTGGGCCAGAAGCGCTGGCAGTACGACGTGTGGTCG
ACTGATGTCACTGTAGCCAACAAGATGGAGGCCGGCGGCATCCCTGGGCGCGTGCACATCTCCCAGAGCACCATGGACTGCCTGAAAGGG
GAGTTTGATGTGGAGCCAGGCGATGGGGGCAGCCGCTGTGATTACCTAGAAGAGAAGGGTATTGAAACCTACCTCATCATTGCCTCCAAG
CCAGAGGTGAAGAAAACAGCCACCCAGAATGGCCTCAATGGCTCGGCCCTGCCCAATGGAGCACCAGCTTCCTCAAAGTCCAGCTCCCCT
GCCCTCATTGAGACCAAGGAGCCCAACGGGAGTGCCCACAGCAGTGGGTCCACGTCGGAGAAGCCCGAGGAGCAGGATGCCCAGGCCGAC
AACCCCTCATTCCCCAACCCACGCCGGAGGCTGCGCCTGCAGGACCTGGCTGACCGAGTGGTGGATGCCTCTGAAGATGAGCACGAGCTC
AACCAGCTGCTCAACGAGGCCCTGCTTGAGCGAGAGTCCGCCCAAGTAGTAAAGAAGAGAAACACCTTCCTCTTGTCCATGCGGTTCATG
GACCCCGAGATGGAAACCCGCTACTCGGTGGAGAAGGAGAAGCAGAGTGGGGCTGCCTTCAGCTGCTCCTGCGTCGTCCTGCTCTGCACG
GCCCTGGTCGAGATACTCATCGACCCCTGGCTAATGACAAACTATGTGACCTTCATGGTGGGGGAGATTCTGCTCCTCATCCTGACCATC
TGCTCCCTGGCTGCCATCTTTCCCCGGGCCTTTCCTAAGAAGCTTGTGGCCTTCTCAACTTGGATTGACCGGACCCGCTGGGCCAGGAAC
ACCTGGGCCATGCTCGCCATCTTCATCCTGGTGATGGCAAATGTCGTGGACATGCTCAGCTGTCTCCAGTACTACACGGGACCCAGCAAT
GCAACGGCAGGGATGGAAACGGAGGGCAGCTGCCTGGAGAACCCCAAGTATTACAACTATGTGGCCGTGCTGTCCCTCATCGCCACCATC
ATGCTGGTGCAGGTCAGCCACATGGTGAAGCTCACGCTCATGCTGCTCGTCGCAGGCGCCGTGGCCACCATCAACCTCTATGCCTGGCGT
CCCGTCTTTGATGAATACGACCACAAGCGTTTTCGGGAGCACGACTTACCTATGGTGGCCTTAGAGCAGATGCAAGGATTCAACCCTGGG
CTCAATGGCACTGACAGGCTGCCCCTGGTGCCTTCCAAGTACTCTATGACGGTGATGGTGTTCCTCATGATGCTCAGCTTCTACTACTTC
TCCCGCCACGTAGAAAAACTGGCACGGACACTTTTCTTGTGGAAGATTGAGGTCCACGACCAGAAGGAACGTGTCTATGAGATGCGACGC
TGGAACGAGGCCTTGGTCACCAACATGTTGCCTGAGCACGTGGCACGCCATTTCCTGGGGTCCAAGAAGAGAGATGAGGAGCTGTATAGC
CAGACGTATGATGAGATTGGAGTCATGTTTGCCTCCCTGCCCAACTTTGCTGACTTCTACACAGAGGAGAGCATCAACAATGGTGGTATT
GAGTGTCTGCGTTTCCTCAATGAAATCATCTCAGATTTTGACTCTCTCCTGGACAATCCCAAGTTCCGGGTGATCACCAAGATCAAAACC
ATTGGCAGCACGTATATGGCGGCTTCAGGAGTCACCCCCGATGTCAACACCAATGGCTTTGCCAGCTCCAACAAGGAAGACAAGTCCGAG
AGAGAGCGCTGGCAGCACCTGGCTGACCTGGCCGACTTCGCGCTGGCCATGAAGGATACGCTCACCAACATCAACAACCAGTCCTTCAAT
AACTTCATGCTGCGCATAGGCATGAACAAAGGCGGGGTTCTGGCTGGGGTCATCGGAGCCCGGAAACCACACTACGACATCTGGGGCAAT
ACAGTCAATGTAGCCAGCAGGATGGAGTCCACGGGGGTCATGGGCAACATTCAGGCAAGTAGCCTGCAGTATGAAATGCTGCTGCTGACG
GATTCTATCTCCAAGGAGGACAGCTGCTGGGAGCTCCGGTTACGCTGTGCTCTCAGCCTTTTCCTCATGGCTGTGAACATTAAGACTCCT
GTGGTGGTTGAAAACATTACCCTCATGTGCCTGAGGATCTTGCAGAAGCTGATAAAACCACCTGCTCCCACTAGCAAGAAGAACAAGGAT
GTCCCCGTTGAGGCCCTCACCACGGTGAAGCCATACTGCAATGAGATCCATGCCCAGGCTCAACTGTGGCTCAAGAGAGACCCCAAGGCA
TCCTATGATGCCTGGAAGAAGTGTCTTCCTATCAGAGGGATAGATGGCAATGGGAAAGCCCCCAGCAAATCAGAGCTCCGCCATCTCTAT
TTGACTGAGAAGTATGTGTGGAGGTGGAAACAGTTCCTGAGTCGTCGGGGGAAGAGGACCTCCCCCTTGGATCTCAAACTGGGGCATAAC
AACTGGCTGCGACAAGTGCTTTTCACTCCAGCAACGCAGGCCGCACGGCAGGCAGCCTGTACCATTGTGGAAGCTCTAGCCACCATTCCC
AGCCGCAAGCAGCAGGTCCTGGACCTGCTTACCAGTTACCTGGATGAGCTGAGCATAGCTGGGGAGTGTGCAGCTGAGTACCTGGCTCTC
TACCAGAAGCTCATCACTTCTGCGCACTGGAAAGTCTACTTGGCAGCTCGGGGAGTCCTACCCTATGTGGGCAACCTCATCACCAAGGAA
ATAGCTCGTCTGCTGGCCCTGGAGGAGGCTACCCTGAGTACCGATCTGCAGCAGGGTTATGCCCTTAAAAGTCTCACAGGCCTTCTCTCC
TCCTTTGTTGAGGTGGAATCCATCAAAAGACATTTTAAAAGTCGCTTGGTGGGTACTGTGCTGAATGGATACCTGTGCTTGCGGAAGCTG
GTGGTGCAGAGGACCAAGCTGATCGATGAGACGCAGGACATGCTGCTGGAGATGCTGGAGGACATGACCACAGGTACAGAATCAGAAACC
AAGGCCTTCATGGCTGTGTGCATTGAGACAGCCAAGCGCTACAATCTGGATGACTACCGGACCCCGGTGTTCATCTTCGAGAGGCTCTGC
AGCATCATTTATCCTGAGGAGAATGAAGTCACTGAGTTCTTTGTGACCCTGGAGAAGGATCCCCAACAAGAAGACTTCTTACAGGGCAGG
ATGCCTGGGAACCCGTATAGCAGCAATGAGCCAGGCATCGGGCCGCTGATGAGGGATATAAAGAACAAGATTTGCCAGGACTGTGACTTA
GTGGCCCTCCTGGAAGATGACAGTGGCATGGAGCTTCTAGTGAACAATAAAATCATTAGTTTGGACCTTCCTGTGGCTGAAGTTTACAAG
AAAGTCTGGTGTACCACGAATGAGGGAGAGCCCATGAGGATTGTTTATCGTATGCGGGGGCTGCTGGGCGATGCCACAGAGGAGTTCATT
GAGTCCCTGGACTCTACTACAGATGAAGAAGAAGATGAAGAAGAAGTGTATAAAATGGCTGGTGTGATGGCCCAGTGTGGGGGCCTGGAA
TGCATGCTTAACAGACTCGCAGGGATCAGAGATTTCAAGCAGGGACGCCACCTTCTAACAGTGCTACTGAAATTGTTCAGTTACTGCGTG
AAGGTGAAAGTCAACCGGCAGCAACTGGTCAAACTGGAAATGAACACCTTGAACGTCATGCTGGGGACCCTAAACCTGGCCCTTGTAGCT
GAACAAGAAAGCAAGGACAGTGGGGGTGCAGCTGTGGCTGAGCAGGTGCTTAGCATCATGGAGATCATTCTAGATGAGTCCAATGCTGAG
CCCCTGAGTGAGGACAAGGGCAACCTCCTCCTGACAGGTGACAAGGATCAACTGGTGATGCTCTTGGACCAGATCAACAGCACCTTTGTT
CGCTCCAACCCCAGTGTGCTCCAGGGCCTGCTTCGCATCATCCCGTACCTTTCCTTTGGAGAGGTGGAGAAAATGCAGATCTTGGTGGAG
CGATTCAAACCATACTGCAACTTTGATAAATATGATGAAGATCACAGTGGTGATGATAAAGTCTTCCTGGACTGCTTCTGTAAAATAGCT
GCTGGCATCAAGAACAACAGCAATGGGCACCAGCTGAAGGATCTGATTCTCCAGAAGGGGATCACCCAGAATGCACTTGACTACATGAAA
AAGCACATCCCTAGCGCCAAGAATTTGGATGCCGACATCTGGAAAAAGTTTTTGTCTCGCCCAGCCTTGCCATTTATCCTAAGGCTGCTT
CGGGGCCTGGCCATCCAGCACCCTGGCACCCAGGTTCTGATTGGAACTGATTCCATCCCGAACCTGCATAAGCTGGAGCAGGTGTCCAGT
GATGAGGGCATTGGGACCTTGGCAGAGAACCTGCTGGAAGCCCTGCGGGAACACCCTGACGTAAACAAGAAGATTGACGCAGCCCGCAGG
GAGACCCGGGCAGAGAAGAAGCGCATGGCCATGGCAATGAGGCAGAAGGCCCTGGGCACCCTGGGCATGACGACAAATGAAAAGGGCCAG
GTCGTGACCAAGACAGCACTCCTGAAGCAGATGGAAGAGCTGATCGAGGAGCCTGGCCTCACGTGCTGCATCTGCAGGGAGGGATACAAG
TTCCAGCCCACAAAGGTCCTGGGCATTTATACCTTCACGAAGCGGGTAGCCTTGGAGGAGATGGAGAATAAGCCCCGGAAACAGCAGGGC
TACAGCACCGTGTCCCACTTCAACATTGTGCACTACGACTGCCATCTGGCTGCCGTCAGGTTGGCTCGAGGCCGGGAAGAGTGGGAGAGT
GCCGCCCTGCAGAATGCCAACACCAAGTGCAACGGGCTCCTTCCGGTCTGGGGACCTCATGTCCCTGAATCAGCTTTTGCCACTTGCTTG
GCAAGACACAACACTTACCTCCAGGAATGTACAGGCCAGCGGGAGCCCACGTATCAGCTCAACATCCATGACATCAAACTGCTCTTCCTG
CGCTTCGCCATGGAGCAGTCGTTCAGCGCAGACACTGGCGGGGGCGGCCGGGAGAGCAACATCCACCTGATCCCGTACATCATTCACACT
GTGCTTTACGTCCTGAACACAACCCGAGCAACTTCCCGAGAAGAGAAGAACCTCCAAGGCTTTCTGGAACAGCCCAAGGAGAAGTGGGTG
GAGAGTGCCTTTGAAGTGGACGGGCCCTACTATTTCACAGTCTTGGCCCTTCACATCCTGCCCCCTGAGCAGTGGAGAGCCACACGTGTG
GAAATCTTGCGGAGGCTGTTGGTGACCTCGCAGGCTCGGGCAGTGGCTCCAGGTGGAGCCACCAGGCTGACAGATAAGGCAGTGAAGGAC
TATTCCGCTTACCGTTCTTCCCTTCTCTTTTGGGCCCTCGTCGATCTCATTTACAACATGTTTAAGAAACAAACAACCCCAACTGTGGGA
GGGATTGACACTGGCAGCCTGGAGCCTTGTGTCTGTGAGAAGGTGCCTACCAGTAACACAGAGGGAGGCTGGTCCTGCTCTCTCGCTGAG
TACATCCGCCACAACGACATGCCCATCTACGAAGCTGCCGACAAAGCCCTGAAAACCTTCCAGGAGGAGTTCATGCCAGTGGAGACCTTC
TCAGAGTTCCTCGATGTGGCCGGTCTTTTATCAGAAATCACCGATCCAGAGAGCTTCCTGAAGGACCTGTTGAACTCAGTCCCCTGACCA
CCACACAGCAGCTGCGGCGGCGAAGACGAAGCTGGCTTGCCTTCCACCCTCTGTTCTCCCTCCTTGTGCATTAAGTTCCCTCCGCGGGAT
GCTGCATTGTTACCCCGCCCTCCCCTCTCTCATTTTTCTTGGTGTGGCTTGGGGTTTTTAGGCTTCCTGTTTTATCTCGTGTGTGTGGTG
CACCAGCTATGAGGTTGTCTGTAACCCAAGCCATCAAAGGGCCTGTACATACCTAGGAGCCATGAGTTGTCCCGGCCAGCTTCATACTTG

>2235_2235_4_ADCY3-UBR4_ADCY3_chr2_25043593_ENST00000260600_UBR4_chr1_19436958_ENST00000375267_length(amino acids)=2324AA_BP=1084
MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDC
YVVVMCAVVFSSDKLASLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFF
ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEE
QSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQ
LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGI
PGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHS
SGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEK
QSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMAN
VVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREH
DLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHV
ARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPD
VNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVM
GNIQASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCN
EIHAQAQLWLKRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHLYLTEKYVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQA
ARQAACTIVEALATIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYLAARGVLPYVGNLITKEIARLLALEEATLST
DLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRY
NLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLV
NNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQ
GRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGD
KDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKD
LILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQVSSDEGIGTLAENLLEA
LREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTK
RVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQR
EPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTV
LALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKQTTPTVGGIDTGSLEPCVCEK

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Fusion Gene PPI Analysis for ADCY3-UBR4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADCY3-UBR4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADCY3-UBR4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADCY3C0005586Bipolar Disorder1PSYGENET
HgeneADCY3C0011875Diabetic Angiopathies1CTD_human
HgeneADCY3C0025945Microangiopathy, Diabetic1CTD_human
HgeneADCY3C0028754Obesity1CTD_human
HgeneADCY3C0028756Obesity, Morbid1CTD_human
HgeneADCY3C0525045Mood Disorders1PSYGENET
TgeneC1720189Episodic Ataxia1GENOMICS_ENGLAND
TgeneC4015108Episodic ataxia with slurred speech1GENOMICS_ENGLAND