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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADD3-VIL1 (FusionGDB2 ID:HG120TG7429)

Fusion Gene Summary for ADD3-VIL1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADD3-VIL1
Fusion gene ID: hg120tg7429
HgeneTgene
Gene symbol

ADD3

VIL1

Gene ID

120

7429

Gene nameadducin 3villin 1
SynonymsADDL|CPSQ3D2S1471|VIL
Cytomap('ADD3')('VIL1')

10q25.1-q25.2

2q35

Type of geneprotein-codingprotein-coding
Descriptiongamma-adducinadducin 3 (gamma)adducin-like protein 70villin-1
Modification date2020031320200313
UniProtAcc

Q9UEY8

.
Ensembl transtripts involved in fusion geneENST00000497125, ENST00000277900, 
ENST00000356080, ENST00000360162, 
Fusion gene scores* DoF score13 X 10 X 5=6503 X 4 X 3=36
# samples 144
** MAII scorelog2(14/650*10)=-2.21501289097085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ADD3 [Title/Abstract] AND VIL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADD3(111877180)-VIL1(219305444), # samples:1
Anticipated loss of major functional domain due to fusion event.ADD3-VIL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADD3-VIL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADD3-VIL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADD3-VIL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneVIL1

GO:0007173

epidermal growth factor receptor signaling pathway

17229814

TgeneVIL1

GO:0008360

regulation of cell shape

16921170

TgeneVIL1

GO:0009617

response to bacterium

17182858

TgeneVIL1

GO:0010634

positive regulation of epithelial cell migration

17229814

TgeneVIL1

GO:0030041

actin filament polymerization

11500485

TgeneVIL1

GO:0030042

actin filament depolymerization

11500485

TgeneVIL1

GO:0030335

positive regulation of cell migration

16921170

TgeneVIL1

GO:0032233

positive regulation of actin filament bundle assembly

19808673

TgeneVIL1

GO:0051014

actin filament severing

16921170|17182858|19808673

TgeneVIL1

GO:0051125

regulation of actin nucleation

16921170|17182858|19808673

TgeneVIL1

GO:0051693

actin filament capping

16921170|17182858|19808673

TgeneVIL1

GO:0060327

cytoplasmic actin-based contraction involved in cell motility

15342783

TgeneVIL1

GO:0071364

cellular response to epidermal growth factor stimulus

17229814


check buttonFusion gene breakpoints across ADD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across VIL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-8604ADD3chr10

111877180

+VIL1chr2

219305444

+


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Fusion Gene ORF analysis for ADD3-VIL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000497125ENST00000248444ADD3chr10

111877180

+VIL1chr2

219305444

+
3UTR-3CDSENST00000497125ENST00000392114ADD3chr10

111877180

+VIL1chr2

219305444

+
3UTR-intronENST00000497125ENST00000440053ADD3chr10

111877180

+VIL1chr2

219305444

+
5CDS-intronENST00000277900ENST00000440053ADD3chr10

111877180

+VIL1chr2

219305444

+
5CDS-intronENST00000356080ENST00000440053ADD3chr10

111877180

+VIL1chr2

219305444

+
5CDS-intronENST00000360162ENST00000440053ADD3chr10

111877180

+VIL1chr2

219305444

+
In-frameENST00000277900ENST00000248444ADD3chr10

111877180

+VIL1chr2

219305444

+
In-frameENST00000277900ENST00000392114ADD3chr10

111877180

+VIL1chr2

219305444

+
In-frameENST00000356080ENST00000248444ADD3chr10

111877180

+VIL1chr2

219305444

+
In-frameENST00000356080ENST00000392114ADD3chr10

111877180

+VIL1chr2

219305444

+
In-frameENST00000360162ENST00000248444ADD3chr10

111877180

+VIL1chr2

219305444

+
In-frameENST00000360162ENST00000392114ADD3chr10

111877180

+VIL1chr2

219305444

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360162ADD3chr10111877180+ENST00000248444VIL1chr2219305444+51589443771198273
ENST00000360162ADD3chr10111877180+ENST00000392114VIL1chr2219305444+13879443771198273
ENST00000356080ADD3chr10111877180+ENST00000248444VIL1chr2219305444+51489343671188273
ENST00000356080ADD3chr10111877180+ENST00000392114VIL1chr2219305444+13779343671188273
ENST00000277900ADD3chr10111877180+ENST00000248444VIL1chr2219305444+51469323651186273
ENST00000277900ADD3chr10111877180+ENST00000392114VIL1chr2219305444+13759323651186273

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360162ENST00000248444ADD3chr10111877180+VIL1chr2219305444+0.0006714210.9993286
ENST00000360162ENST00000392114ADD3chr10111877180+VIL1chr2219305444+0.0022483440.99775165
ENST00000356080ENST00000248444ADD3chr10111877180+VIL1chr2219305444+0.0007357430.9992643
ENST00000356080ENST00000392114ADD3chr10111877180+VIL1chr2219305444+0.0036407550.9963593
ENST00000277900ENST00000248444ADD3chr10111877180+VIL1chr2219305444+0.0007374320.9992625
ENST00000277900ENST00000392114ADD3chr10111877180+VIL1chr2219305444+0.0038647950.99613523

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Fusion Genomic Features for ADD3-VIL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ADD3chr10111877180+VIL1chr2219305444+2.63E-091
ADD3chr10111877180+VIL1chr2219305444+2.63E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ADD3-VIL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:111877180/chr2:219305444)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADD3

Q9UEY8

.
FUNCTION: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin. {ECO:0000269|PubMed:23836506}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneVIL1chr10:111877180chr2:219305444ENST000002484441720761_827743828.0DomainHP
TgeneVIL1chr10:111877180chr2:219305444ENST000002484441720816_824743828.0RegionNote=LPA/PIP2-binding site 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneVIL1chr10:111877180chr2:219305444ENST000002484441720112_119743828.0RegionNote=LPA/PIP2-binding site 1
TgeneVIL1chr10:111877180chr2:219305444ENST000002484441720138_146743828.0RegionNote=LPA/PIP2-binding site 2
TgeneVIL1chr10:111877180chr2:219305444ENST0000024844417202_126743828.0RegionNote=Necessary for homodimerization
TgeneVIL1chr10:111877180chr2:219305444ENST0000024844417202_734743828.0RegionNote=Core
TgeneVIL1chr10:111877180chr2:219305444ENST000002484441720735_827743828.0RegionNote=Headpiece
TgeneVIL1chr10:111877180chr2:219305444ENST000002484441720148_188743828.0RepeatNote=Gelsolin-like 2
TgeneVIL1chr10:111877180chr2:219305444ENST000002484441720265_309743828.0RepeatNote=Gelsolin-like 3
TgeneVIL1chr10:111877180chr2:219305444ENST00000248444172027_76743828.0RepeatNote=Gelsolin-like 1
TgeneVIL1chr10:111877180chr2:219305444ENST000002484441720407_457743828.0RepeatNote=Gelsolin-like 4
TgeneVIL1chr10:111877180chr2:219305444ENST000002484441720528_568743828.0RepeatNote=Gelsolin-like 5
TgeneVIL1chr10:111877180chr2:219305444ENST000002484441720631_672743828.0RepeatNote=Gelsolin-like 6


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Fusion Gene Sequence for ADD3-VIL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2315_2315_1_ADD3-VIL1_ADD3_chr10_111877180_ENST00000277900_VIL1_chr2_219305444_ENST00000248444_length(transcript)=5146nt_BP=932nt
GGCGCTCGGCTAGTCCCGCCAGAGCGCGAGCCGCCAGCCCGTAACGGTCGCCAGTGTGAGGGGCGGGAGGGAAAGAAGAGGGGTTTAAAT
TAGATTTTTTAAAACACAGAGCAAGCGCCAGAGGCGTCGGCATCCCAGGTGTCGCCGCTTCCTGCTGCACAGGGCTCGGCGTACAGGTCC
CTCCCTCCTCAAGCCCCCTCCCCTTCTCCCGCCCTACCCTCTGGGGCTCTGCGGCGCTTAAGAGGCGGCCGCAGCGGCGGATCCGGCGGC
TGCTGCAGCCCGGGCGGCTGCCGAGAAGGAGGGAGGGGAAACACAAAGCCGGCTACGCGCTGCGAGATAACAAGAGTAATCCACAGACTT
AAAACATGAGCTCAGATGCCAGCCAAGGCGTGATTACCACTCCTCCTCCTCCCAGCATGCCTCACAAAGAGAGATATTTTGACCGCATCA
ATGAAAATGACCCAGAATACATTAGGGAGAGGAACATGTCTCCTGATCTACGACAAGACTTCAACATGATGGAGCAGAGGAAACGAGTTA
CTCAGATCCTGCAAAGTCCTGCCTTTCGGGAAGACTTGGAATGCCTTATTCAAGAACAGATGAAGAAAGGCCACAACCCAACTGGATTAC
TAGCATTACAGCAGATTGCAGATTACATCATGGCCAATTCTTTCTCGGGTTTTTCTTCACCTCCTCTCAGTCTTGGCATGGTCACACCTA
TCAATGACCTTCCTGGTGCAGATACATCCTCATATGTGAAGGGAGAAAAACTTACTCGCTGTAAACTTGCCAGCCTGTACAGACTTGTAG
ACTTGTTTGGATGGGCACACCTGGCAAATACCTATATCTCAGTAAGAATAAGTAAGGAGCAAGACCACATTATAATAATTCCCAGAGGCC
TATCTTTTTCTGAAGCTACAGCCTCCAATTTGGAGGTCACAAGCCCCAAAGTGGACGTGTTCAATGCTAACAGCAACCTCAGTTCTGGGC
CTCTGCCCATCTTCCCCCTGGAGCAGCTAGTGAACAAGCCTGTAGAGGAGCTCCCCGAGGGTGTGGACCCCAGCAGGAAGGAGGAACACC
TGTCCATTGAAGATTTCACTCAGGCCTTTGGGATGACTCCAGCTGCCTTCTCTGCTCTGCCTCGATGGAAGCAACAAAACCTCAAGAAAG
AAAAAGGACTATTTTGAGAAGAGTAGCTGTGGTTGTAAAGCAGTACCCTACCCTGATTGTAGGGTCTCATTTTCTCACCGATATTAGTCC
TACACCAATTGAAGTGAAATTTTGCAGATGTGCCTATGAGCACAAACTTCTGTGGCAAATGCCAGTTTTGTTTAATAATGTACCTATTCC
TTCAGAAAGATGATACCCCAAAAGGAGCCTATGGTCCTCATTTCAACTTCTAAGGTCGCTAGATTGTTTCTATCCTGAGGTATTGCATCA
ATTTTAATACTCCTATAGTTTTCTCTTCTTAGAAGAGCACAAACACTCCATGGAACATTAGAGTTCTGAGGCACTACCCTAGCTTGTCCT
CTATCATGACTCATTTTTATCTATGGCAGGTAGGCTGAAGCACTTTGCAGGTTTACATCTTCCCCAGAGTAACAGCTTTTCCTTTTCACA
TATACTTTCCTTACTGCCTTACTCAGTGGGTAAGTTAAAGGGCTGAAGGAGAGTTGAATGGTCCACAAGACTACCCTCTTAAGAGGTTTC
ACAAATTCCAAACAGTACCAGTGAGAGCAGCACTTCCACTGGGGCTAGGCTTGAGACCTAAAGGCAAGTATGAAATGCATATGCTACTTC
ACTCCCTCTCCCAACCCTTAATAATGAGGCAAAGCAAGAGCCTAGTGAAGGCCAATGCTAGGTTTACAAACTTACCCAGAAGCCTCTGCA
AAGCTTCACAGGCTCCTCAGATGAAAATAACAGGAATCAATGGGGACTACGGCCAGACACTGGTTTGCCATTCTGTTCCTTTTAAGAAGT
AACAGTGCTGCAAGGAAGTCCATGTCAGAAAGCCAACAGAAGGTGATTTCCACAACTTTGAACAGGTTGTTACAAGTATCAGCAAGAATG
TGTCCTTTTCAGAAATAACAGTCAAATCAAAGAAGGTTAATAAAGGCTTTAATTTCATACACACAAAAAAACTCTATGCATAATTTAAAA
AGGAAACAAAAACAAAGAAAAACCGTAAAGGATACAGAGGAACAGTTCTGCTAAAACACAGATAAAAGTGCCGCTCCATACAAAACATAA
AGAATCAGAATCAAAAGTCACTCTGAACATAAAGAAAAAAAATCATCTCACAAATAATGTGGCCACAGCTGCCAGAAAACCTGGTAGTGG
CTCAATTAGGCAAAGTGTAGGAATCTCATTTTTGTTTTTCTCTCCTTAAGTTTAAAGAAACAACAATGACAATAGGCCAGAGAAGTTAGG
GAGGGAAAGAAAAGCTCAAAGGGAGGGAAACCTGGGGACAAGAGGTGTGCACACCCACATGTGGTCTCACTCTTCACACAGGCCCACTAT
TTTTGAAGTAGACCAGTTTAGTTGACTGTTCTTCTTTGTTCTGGCATCTGACTGGACCAACCTGGAACCTGGTCCAGACCCTCACCCACT
CTATTCTTATGCCAATGGACATACCTATACTTTGAACCTCTGTACTTTTAAGAAAAGTCCAATGTTACAAAATCAAATGCTTATATTCAG
ACTGGCACACTTTTTAAATAAAAACTCCATACACCTCAGACATATAGCACACATGGAGACAACTTACTAATTGTGTGTAAGTATGATACA
ATGAATGAGACTGCCTGAAGTCTAGTAATCAAAGCATGCCATAAGGTGAATGATTGTGGTTAAACACAGCAAAATAATTGTCACAAAACT
TTCAAGGCCTAACAAATTAGAATTTTCCAATAAAAAATATATATTTTTTCAGATGTTAATAAGACATATCAGTAGAGACAAAATTAGGAT
TTTGAAGTAATGCAATAAAAAGATGTTGGAGGGCAGAAGTCTATTTAGTTTTTGTATACACTTGCAAGAGTGCATTACTCAGTATAAAGC
AAAATGGGGAGGAAAAAGACATCCATCCATTTTATTGGAACACTTTTATGTGACTTGAATCTGGTGTTAGGTTGTTGATTTTTCTAAAAA
TCTCCTATATATACAAAATCCATATGTACTTGGAGATCCAGCTGTTGCCCCCTGTTTAAAACAAAAGACCACCTCGGGGGGTCAATTAAA
TTAAAAAGGCCCTCCAACCACCCTAAATGGGATAACTAAGAGTATCTACTGCAGTCATTTCAGAGGACAGAGAAGGAAAATATTTTAATT
TGCTTTAATATAACCTCTTTTCAGTAGATCACAAATGAGTTTACAAACTACTTTTTTTTCTCTTTAATTTAGGTGTTTGCAGATAATTTT
CATTATATCCGTAGCTGTATGTGTGTATAGTTACATAATGGTAACTACACACGATACAGAAGAATCAGTAAATTCATGGATTATTTTGCT
GAGGTTTTAAATTTTAAAGCCTCTGTTTCAGAATTTTATACTTGATCAAGGAGAAAAATAAATGTGTAGTCTAACATTTGCTTTCTGGAG
TTAATTAACTGATCTGTAAGAACCACTGCATATGTCTTAAAATGTAAACATATTTACATTTGTTGTATTTGTTATTGAGCCTTTAAGGTT
AGGCCCAGAATGAACAGACCATAGCAAGTAAACAAATAATTTTTAGAATCAAAGTATTAATAGAAGACCAGTTCATGGATTTGCTTATTC
TATCCTGCTGAGACAAAACTCATGAGTGTGCACACACATGTGAATATATCCCTACGAAACAGTCTATCTTCTCATAGGCTTAAATTATAG
TCATGGCTATTAAAGAAATTAACAGCATCCAGCCACATGCAACTTTCCAACCTTCAGTACTATTAGGTGATTAAAATCAACAAATATGAA
GTTTAGTTCATTTTTCCCTTAAAATTCCAACAAAGATCAAAAGGTTGTATCTAGAACTAATTGCCATCAAGTTCCAATTCAATGTCATTT
AAAGTAATGTAACCACACATTTGGTATTTTCAATAGGAAGGTTAATTAGGTATTGTGCAAACTGCCTGCAACGGAAGCACTCAGTCCTTA
TCTAACTTGTCCCTTCCTGGCCCCAACATGCTAACTGCCCCATCCCCAATTCTGGGCAAACTGATCACAATGTGCAAAAAATAATATATT
ATCTATTTATAATTTTAAAATATATACAGCCAGCTCAAAAACAACAACAAACCCCATCAACATAGTCCAGCTGAAATCTCCACTGGTAGT
CAAAGAAGTAGATTAAAGGAGTAAAGGAAGGAGAAGGCTGATAGGGCCACAAGAATGGACAGACATCAAGTAAAATTTGAGTCCCAAACA
TGCAAGTACATGAGCAGTGAGATAACTTATATATTCCAATAACCTATTTTCAACAACTCCTGCCCAAGACATGAAGATCAAATCAGGTTT
CTGAGGTAAGTGTACTTCTAAACCATACACACATGAAAGCTATGAAAGCAATTCAAATGAGGCTGCTTCATGAGGCAATCTAGACTTATG
GCATTATTTCTACTTTTCTCCATGTTTTAATTGCAGCCTGCACTTTAAATCTTTCCCAATAATTTTTAACAGTGCCTCTCAAATGCAAAG
ACACGTAAAAGAATTAATAACTAGCCAAAGAATTTTATCACCGCTTCACTCATTTATAAGAAAACCAATTATTTCCAAGCAAAATCAAAC
CAAACCAAAGAGGCTCCTGGTAGAAATGAAACAAAACTTTAAAGCTAGTTTTAAAACAAATATTTTCCTCTGCTCTAAACTACTCTGGCG
TTTTCTACCACTCTACCATTTTGGAACATTCATTACAATAAGGTATATAGGTAGATGGTAGGAGGCAAAGCATTTATCAGTAGTTGAGCA
AAACTGCTGAGGCCATTTATAATTCAAAGAATGAAAACTTAGAATAGTTTACTACATTAGAATACATCCAAGTTCCAAGAGTAGGACTGG
AGCTCTCTTAAGGCAATCTTTCAGAAAAGATGTTGCATCTTCTGTGATGATGGTTTGTGTTTTTTTTGTTTTTGTTTTCGTTTTTTTTAA

>2315_2315_1_ADD3-VIL1_ADD3_chr10_111877180_ENST00000277900_VIL1_chr2_219305444_ENST00000248444_length(amino acids)=273AA_BP=189
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLEVTSPKVDVFNANSNLSSGPLPIFPLEQLVNKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKEK

--------------------------------------------------------------
>2315_2315_2_ADD3-VIL1_ADD3_chr10_111877180_ENST00000277900_VIL1_chr2_219305444_ENST00000392114_length(transcript)=1375nt_BP=932nt
GGCGCTCGGCTAGTCCCGCCAGAGCGCGAGCCGCCAGCCCGTAACGGTCGCCAGTGTGAGGGGCGGGAGGGAAAGAAGAGGGGTTTAAAT
TAGATTTTTTAAAACACAGAGCAAGCGCCAGAGGCGTCGGCATCCCAGGTGTCGCCGCTTCCTGCTGCACAGGGCTCGGCGTACAGGTCC
CTCCCTCCTCAAGCCCCCTCCCCTTCTCCCGCCCTACCCTCTGGGGCTCTGCGGCGCTTAAGAGGCGGCCGCAGCGGCGGATCCGGCGGC
TGCTGCAGCCCGGGCGGCTGCCGAGAAGGAGGGAGGGGAAACACAAAGCCGGCTACGCGCTGCGAGATAACAAGAGTAATCCACAGACTT
AAAACATGAGCTCAGATGCCAGCCAAGGCGTGATTACCACTCCTCCTCCTCCCAGCATGCCTCACAAAGAGAGATATTTTGACCGCATCA
ATGAAAATGACCCAGAATACATTAGGGAGAGGAACATGTCTCCTGATCTACGACAAGACTTCAACATGATGGAGCAGAGGAAACGAGTTA
CTCAGATCCTGCAAAGTCCTGCCTTTCGGGAAGACTTGGAATGCCTTATTCAAGAACAGATGAAGAAAGGCCACAACCCAACTGGATTAC
TAGCATTACAGCAGATTGCAGATTACATCATGGCCAATTCTTTCTCGGGTTTTTCTTCACCTCCTCTCAGTCTTGGCATGGTCACACCTA
TCAATGACCTTCCTGGTGCAGATACATCCTCATATGTGAAGGGAGAAAAACTTACTCGCTGTAAACTTGCCAGCCTGTACAGACTTGTAG
ACTTGTTTGGATGGGCACACCTGGCAAATACCTATATCTCAGTAAGAATAAGTAAGGAGCAAGACCACATTATAATAATTCCCAGAGGCC
TATCTTTTTCTGAAGCTACAGCCTCCAATTTGGAGGTCACAAGCCCCAAAGTGGACGTGTTCAATGCTAACAGCAACCTCAGTTCTGGGC
CTCTGCCCATCTTCCCCCTGGAGCAGCTAGTGAACAAGCCTGTAGAGGAGCTCCCCGAGGGTGTGGACCCCAGCAGGAAGGAGGAACACC
TGTCCATTGAAGATTTCACTCAGGCCTTTGGGATGACTCCAGCTGCCTTCTCTGCTCTGCCTCGATGGAAGCAACAAAACCTCAAGAAAG
AAAAAGGACTATTTTGAGAAGAGTAGCTGTGGTTGTAAAGCAGTACCCTACCCTGATTGTAGGGTCTCATTTTCTCACCGATATTAGTCC
TACACCAATTGAAGTGAAATTTTGCAGATGTGCCTATGAGCACAAACTTCTGTGGCAAATGCCAGTTTTGTTTAATAATGTACCTATTCC

>2315_2315_2_ADD3-VIL1_ADD3_chr10_111877180_ENST00000277900_VIL1_chr2_219305444_ENST00000392114_length(amino acids)=273AA_BP=189
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLEVTSPKVDVFNANSNLSSGPLPIFPLEQLVNKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKEK

--------------------------------------------------------------
>2315_2315_3_ADD3-VIL1_ADD3_chr10_111877180_ENST00000356080_VIL1_chr2_219305444_ENST00000248444_length(transcript)=5148nt_BP=934nt
GGGGCGCTCGGCTAGTCCCGCCAGAGCGCGAGCCGCCAGCCCGTAACGGTCGCCAGTGTGAGGGGCGGGAGGGAAAGAAGAGGGGTTTAA
ATTAGATTTTTTAAAACACAGAGCAAGCGCCAGAGGCGTCGGCATCCCAGGTGTCGCCGCTTCCTGCTGCACAGGGCTCGGCGTACAGGT
CCCTCCCTCCTCAAGCCCCCTCCCCTTCTCCCGCCCTACCCTCTGGGGCTCTGCGGCGCTTAAGAGGCGGCCGCAGCGGCGGATCCGGCG
GCTGCTGCAGCCCGGGCGGCTGCCGAGAAGGAGGGAGGGGAAACACAAAGCCGGCTACGCGCTGCGAGATAACAAGAGTAATCCACAGAC
TTAAAACATGAGCTCAGATGCCAGCCAAGGCGTGATTACCACTCCTCCTCCTCCCAGCATGCCTCACAAAGAGAGATATTTTGACCGCAT
CAATGAAAATGACCCAGAATACATTAGGGAGAGGAACATGTCTCCTGATCTACGACAAGACTTCAACATGATGGAGCAGAGGAAACGAGT
TACTCAGATCCTGCAAAGTCCTGCCTTTCGGGAAGACTTGGAATGCCTTATTCAAGAACAGATGAAGAAAGGCCACAACCCAACTGGATT
ACTAGCATTACAGCAGATTGCAGATTACATCATGGCCAATTCTTTCTCGGGTTTTTCTTCACCTCCTCTCAGTCTTGGCATGGTCACACC
TATCAATGACCTTCCTGGTGCAGATACATCCTCATATGTGAAGGGAGAAAAACTTACTCGCTGTAAACTTGCCAGCCTGTACAGACTTGT
AGACTTGTTTGGATGGGCACACCTGGCAAATACCTATATCTCAGTAAGAATAAGTAAGGAGCAAGACCACATTATAATAATTCCCAGAGG
CCTATCTTTTTCTGAAGCTACAGCCTCCAATTTGGAGGTCACAAGCCCCAAAGTGGACGTGTTCAATGCTAACAGCAACCTCAGTTCTGG
GCCTCTGCCCATCTTCCCCCTGGAGCAGCTAGTGAACAAGCCTGTAGAGGAGCTCCCCGAGGGTGTGGACCCCAGCAGGAAGGAGGAACA
CCTGTCCATTGAAGATTTCACTCAGGCCTTTGGGATGACTCCAGCTGCCTTCTCTGCTCTGCCTCGATGGAAGCAACAAAACCTCAAGAA
AGAAAAAGGACTATTTTGAGAAGAGTAGCTGTGGTTGTAAAGCAGTACCCTACCCTGATTGTAGGGTCTCATTTTCTCACCGATATTAGT
CCTACACCAATTGAAGTGAAATTTTGCAGATGTGCCTATGAGCACAAACTTCTGTGGCAAATGCCAGTTTTGTTTAATAATGTACCTATT
CCTTCAGAAAGATGATACCCCAAAAGGAGCCTATGGTCCTCATTTCAACTTCTAAGGTCGCTAGATTGTTTCTATCCTGAGGTATTGCAT
CAATTTTAATACTCCTATAGTTTTCTCTTCTTAGAAGAGCACAAACACTCCATGGAACATTAGAGTTCTGAGGCACTACCCTAGCTTGTC
CTCTATCATGACTCATTTTTATCTATGGCAGGTAGGCTGAAGCACTTTGCAGGTTTACATCTTCCCCAGAGTAACAGCTTTTCCTTTTCA
CATATACTTTCCTTACTGCCTTACTCAGTGGGTAAGTTAAAGGGCTGAAGGAGAGTTGAATGGTCCACAAGACTACCCTCTTAAGAGGTT
TCACAAATTCCAAACAGTACCAGTGAGAGCAGCACTTCCACTGGGGCTAGGCTTGAGACCTAAAGGCAAGTATGAAATGCATATGCTACT
TCACTCCCTCTCCCAACCCTTAATAATGAGGCAAAGCAAGAGCCTAGTGAAGGCCAATGCTAGGTTTACAAACTTACCCAGAAGCCTCTG
CAAAGCTTCACAGGCTCCTCAGATGAAAATAACAGGAATCAATGGGGACTACGGCCAGACACTGGTTTGCCATTCTGTTCCTTTTAAGAA
GTAACAGTGCTGCAAGGAAGTCCATGTCAGAAAGCCAACAGAAGGTGATTTCCACAACTTTGAACAGGTTGTTACAAGTATCAGCAAGAA
TGTGTCCTTTTCAGAAATAACAGTCAAATCAAAGAAGGTTAATAAAGGCTTTAATTTCATACACACAAAAAAACTCTATGCATAATTTAA
AAAGGAAACAAAAACAAAGAAAAACCGTAAAGGATACAGAGGAACAGTTCTGCTAAAACACAGATAAAAGTGCCGCTCCATACAAAACAT
AAAGAATCAGAATCAAAAGTCACTCTGAACATAAAGAAAAAAAATCATCTCACAAATAATGTGGCCACAGCTGCCAGAAAACCTGGTAGT
GGCTCAATTAGGCAAAGTGTAGGAATCTCATTTTTGTTTTTCTCTCCTTAAGTTTAAAGAAACAACAATGACAATAGGCCAGAGAAGTTA
GGGAGGGAAAGAAAAGCTCAAAGGGAGGGAAACCTGGGGACAAGAGGTGTGCACACCCACATGTGGTCTCACTCTTCACACAGGCCCACT
ATTTTTGAAGTAGACCAGTTTAGTTGACTGTTCTTCTTTGTTCTGGCATCTGACTGGACCAACCTGGAACCTGGTCCAGACCCTCACCCA
CTCTATTCTTATGCCAATGGACATACCTATACTTTGAACCTCTGTACTTTTAAGAAAAGTCCAATGTTACAAAATCAAATGCTTATATTC
AGACTGGCACACTTTTTAAATAAAAACTCCATACACCTCAGACATATAGCACACATGGAGACAACTTACTAATTGTGTGTAAGTATGATA
CAATGAATGAGACTGCCTGAAGTCTAGTAATCAAAGCATGCCATAAGGTGAATGATTGTGGTTAAACACAGCAAAATAATTGTCACAAAA
CTTTCAAGGCCTAACAAATTAGAATTTTCCAATAAAAAATATATATTTTTTCAGATGTTAATAAGACATATCAGTAGAGACAAAATTAGG
ATTTTGAAGTAATGCAATAAAAAGATGTTGGAGGGCAGAAGTCTATTTAGTTTTTGTATACACTTGCAAGAGTGCATTACTCAGTATAAA
GCAAAATGGGGAGGAAAAAGACATCCATCCATTTTATTGGAACACTTTTATGTGACTTGAATCTGGTGTTAGGTTGTTGATTTTTCTAAA
AATCTCCTATATATACAAAATCCATATGTACTTGGAGATCCAGCTGTTGCCCCCTGTTTAAAACAAAAGACCACCTCGGGGGGTCAATTA
AATTAAAAAGGCCCTCCAACCACCCTAAATGGGATAACTAAGAGTATCTACTGCAGTCATTTCAGAGGACAGAGAAGGAAAATATTTTAA
TTTGCTTTAATATAACCTCTTTTCAGTAGATCACAAATGAGTTTACAAACTACTTTTTTTTCTCTTTAATTTAGGTGTTTGCAGATAATT
TTCATTATATCCGTAGCTGTATGTGTGTATAGTTACATAATGGTAACTACACACGATACAGAAGAATCAGTAAATTCATGGATTATTTTG
CTGAGGTTTTAAATTTTAAAGCCTCTGTTTCAGAATTTTATACTTGATCAAGGAGAAAAATAAATGTGTAGTCTAACATTTGCTTTCTGG
AGTTAATTAACTGATCTGTAAGAACCACTGCATATGTCTTAAAATGTAAACATATTTACATTTGTTGTATTTGTTATTGAGCCTTTAAGG
TTAGGCCCAGAATGAACAGACCATAGCAAGTAAACAAATAATTTTTAGAATCAAAGTATTAATAGAAGACCAGTTCATGGATTTGCTTAT
TCTATCCTGCTGAGACAAAACTCATGAGTGTGCACACACATGTGAATATATCCCTACGAAACAGTCTATCTTCTCATAGGCTTAAATTAT
AGTCATGGCTATTAAAGAAATTAACAGCATCCAGCCACATGCAACTTTCCAACCTTCAGTACTATTAGGTGATTAAAATCAACAAATATG
AAGTTTAGTTCATTTTTCCCTTAAAATTCCAACAAAGATCAAAAGGTTGTATCTAGAACTAATTGCCATCAAGTTCCAATTCAATGTCAT
TTAAAGTAATGTAACCACACATTTGGTATTTTCAATAGGAAGGTTAATTAGGTATTGTGCAAACTGCCTGCAACGGAAGCACTCAGTCCT
TATCTAACTTGTCCCTTCCTGGCCCCAACATGCTAACTGCCCCATCCCCAATTCTGGGCAAACTGATCACAATGTGCAAAAAATAATATA
TTATCTATTTATAATTTTAAAATATATACAGCCAGCTCAAAAACAACAACAAACCCCATCAACATAGTCCAGCTGAAATCTCCACTGGTA
GTCAAAGAAGTAGATTAAAGGAGTAAAGGAAGGAGAAGGCTGATAGGGCCACAAGAATGGACAGACATCAAGTAAAATTTGAGTCCCAAA
CATGCAAGTACATGAGCAGTGAGATAACTTATATATTCCAATAACCTATTTTCAACAACTCCTGCCCAAGACATGAAGATCAAATCAGGT
TTCTGAGGTAAGTGTACTTCTAAACCATACACACATGAAAGCTATGAAAGCAATTCAAATGAGGCTGCTTCATGAGGCAATCTAGACTTA
TGGCATTATTTCTACTTTTCTCCATGTTTTAATTGCAGCCTGCACTTTAAATCTTTCCCAATAATTTTTAACAGTGCCTCTCAAATGCAA
AGACACGTAAAAGAATTAATAACTAGCCAAAGAATTTTATCACCGCTTCACTCATTTATAAGAAAACCAATTATTTCCAAGCAAAATCAA
ACCAAACCAAAGAGGCTCCTGGTAGAAATGAAACAAAACTTTAAAGCTAGTTTTAAAACAAATATTTTCCTCTGCTCTAAACTACTCTGG
CGTTTTCTACCACTCTACCATTTTGGAACATTCATTACAATAAGGTATATAGGTAGATGGTAGGAGGCAAAGCATTTATCAGTAGTTGAG
CAAAACTGCTGAGGCCATTTATAATTCAAAGAATGAAAACTTAGAATAGTTTACTACATTAGAATACATCCAAGTTCCAAGAGTAGGACT
GGAGCTCTCTTAAGGCAATCTTTCAGAAAAGATGTTGCATCTTCTGTGATGATGGTTTGTGTTTTTTTTGTTTTTGTTTTCGTTTTTTTT

>2315_2315_3_ADD3-VIL1_ADD3_chr10_111877180_ENST00000356080_VIL1_chr2_219305444_ENST00000248444_length(amino acids)=273AA_BP=189
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLEVTSPKVDVFNANSNLSSGPLPIFPLEQLVNKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKEK

--------------------------------------------------------------
>2315_2315_4_ADD3-VIL1_ADD3_chr10_111877180_ENST00000356080_VIL1_chr2_219305444_ENST00000392114_length(transcript)=1377nt_BP=934nt
GGGGCGCTCGGCTAGTCCCGCCAGAGCGCGAGCCGCCAGCCCGTAACGGTCGCCAGTGTGAGGGGCGGGAGGGAAAGAAGAGGGGTTTAA
ATTAGATTTTTTAAAACACAGAGCAAGCGCCAGAGGCGTCGGCATCCCAGGTGTCGCCGCTTCCTGCTGCACAGGGCTCGGCGTACAGGT
CCCTCCCTCCTCAAGCCCCCTCCCCTTCTCCCGCCCTACCCTCTGGGGCTCTGCGGCGCTTAAGAGGCGGCCGCAGCGGCGGATCCGGCG
GCTGCTGCAGCCCGGGCGGCTGCCGAGAAGGAGGGAGGGGAAACACAAAGCCGGCTACGCGCTGCGAGATAACAAGAGTAATCCACAGAC
TTAAAACATGAGCTCAGATGCCAGCCAAGGCGTGATTACCACTCCTCCTCCTCCCAGCATGCCTCACAAAGAGAGATATTTTGACCGCAT
CAATGAAAATGACCCAGAATACATTAGGGAGAGGAACATGTCTCCTGATCTACGACAAGACTTCAACATGATGGAGCAGAGGAAACGAGT
TACTCAGATCCTGCAAAGTCCTGCCTTTCGGGAAGACTTGGAATGCCTTATTCAAGAACAGATGAAGAAAGGCCACAACCCAACTGGATT
ACTAGCATTACAGCAGATTGCAGATTACATCATGGCCAATTCTTTCTCGGGTTTTTCTTCACCTCCTCTCAGTCTTGGCATGGTCACACC
TATCAATGACCTTCCTGGTGCAGATACATCCTCATATGTGAAGGGAGAAAAACTTACTCGCTGTAAACTTGCCAGCCTGTACAGACTTGT
AGACTTGTTTGGATGGGCACACCTGGCAAATACCTATATCTCAGTAAGAATAAGTAAGGAGCAAGACCACATTATAATAATTCCCAGAGG
CCTATCTTTTTCTGAAGCTACAGCCTCCAATTTGGAGGTCACAAGCCCCAAAGTGGACGTGTTCAATGCTAACAGCAACCTCAGTTCTGG
GCCTCTGCCCATCTTCCCCCTGGAGCAGCTAGTGAACAAGCCTGTAGAGGAGCTCCCCGAGGGTGTGGACCCCAGCAGGAAGGAGGAACA
CCTGTCCATTGAAGATTTCACTCAGGCCTTTGGGATGACTCCAGCTGCCTTCTCTGCTCTGCCTCGATGGAAGCAACAAAACCTCAAGAA
AGAAAAAGGACTATTTTGAGAAGAGTAGCTGTGGTTGTAAAGCAGTACCCTACCCTGATTGTAGGGTCTCATTTTCTCACCGATATTAGT
CCTACACCAATTGAAGTGAAATTTTGCAGATGTGCCTATGAGCACAAACTTCTGTGGCAAATGCCAGTTTTGTTTAATAATGTACCTATT

>2315_2315_4_ADD3-VIL1_ADD3_chr10_111877180_ENST00000356080_VIL1_chr2_219305444_ENST00000392114_length(amino acids)=273AA_BP=189
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLEVTSPKVDVFNANSNLSSGPLPIFPLEQLVNKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKEK

--------------------------------------------------------------
>2315_2315_5_ADD3-VIL1_ADD3_chr10_111877180_ENST00000360162_VIL1_chr2_219305444_ENST00000248444_length(transcript)=5158nt_BP=944nt
AGTCCACAAAACTCCCTGATTCCATCCTCTCTGCCTCTTATGAAGCAATACTAGAGAGGAAAAACAAAACCCATTCCTTTAAGAAAGATT
CCGCCTCCTCTCATAAGCAAGCGCCTAATGGTAATTGTAGAGTTTACTAAGTCAAACACTTACTACTCAGCATTGAGAGAAGCTGCTGCT
GCTAATGCTGCTGCTGCTGCTGCCGCCGCCGCCGCTGCTGCTGCTGCTGTTGGTCTGAGGCTGCAGTAGGTTTCTGTGCAGCATTGCAGA
ATCCACACCTAGAGAACAGAAGACACAGACACGTACGTCTACTACCCTTGTTAGAAGGAAGCTTTGGATCTTCGGTGGATAACAAGAGTA
ATCCACAGACTTAAAACATGAGCTCAGATGCCAGCCAAGGCGTGATTACCACTCCTCCTCCTCCCAGCATGCCTCACAAAGAGAGATATT
TTGACCGCATCAATGAAAATGACCCAGAATACATTAGGGAGAGGAACATGTCTCCTGATCTACGACAAGACTTCAACATGATGGAGCAGA
GGAAACGAGTTACTCAGATCCTGCAAAGTCCTGCCTTTCGGGAAGACTTGGAATGCCTTATTCAAGAACAGATGAAGAAAGGCCACAACC
CAACTGGATTACTAGCATTACAGCAGATTGCAGATTACATCATGGCCAATTCTTTCTCGGGTTTTTCTTCACCTCCTCTCAGTCTTGGCA
TGGTCACACCTATCAATGACCTTCCTGGTGCAGATACATCCTCATATGTGAAGGGAGAAAAACTTACTCGCTGTAAACTTGCCAGCCTGT
ACAGACTTGTAGACTTGTTTGGATGGGCACACCTGGCAAATACCTATATCTCAGTAAGAATAAGTAAGGAGCAAGACCACATTATAATAA
TTCCCAGAGGCCTATCTTTTTCTGAAGCTACAGCCTCCAATTTGGAGGTCACAAGCCCCAAAGTGGACGTGTTCAATGCTAACAGCAACC
TCAGTTCTGGGCCTCTGCCCATCTTCCCCCTGGAGCAGCTAGTGAACAAGCCTGTAGAGGAGCTCCCCGAGGGTGTGGACCCCAGCAGGA
AGGAGGAACACCTGTCCATTGAAGATTTCACTCAGGCCTTTGGGATGACTCCAGCTGCCTTCTCTGCTCTGCCTCGATGGAAGCAACAAA
ACCTCAAGAAAGAAAAAGGACTATTTTGAGAAGAGTAGCTGTGGTTGTAAAGCAGTACCCTACCCTGATTGTAGGGTCTCATTTTCTCAC
CGATATTAGTCCTACACCAATTGAAGTGAAATTTTGCAGATGTGCCTATGAGCACAAACTTCTGTGGCAAATGCCAGTTTTGTTTAATAA
TGTACCTATTCCTTCAGAAAGATGATACCCCAAAAGGAGCCTATGGTCCTCATTTCAACTTCTAAGGTCGCTAGATTGTTTCTATCCTGA
GGTATTGCATCAATTTTAATACTCCTATAGTTTTCTCTTCTTAGAAGAGCACAAACACTCCATGGAACATTAGAGTTCTGAGGCACTACC
CTAGCTTGTCCTCTATCATGACTCATTTTTATCTATGGCAGGTAGGCTGAAGCACTTTGCAGGTTTACATCTTCCCCAGAGTAACAGCTT
TTCCTTTTCACATATACTTTCCTTACTGCCTTACTCAGTGGGTAAGTTAAAGGGCTGAAGGAGAGTTGAATGGTCCACAAGACTACCCTC
TTAAGAGGTTTCACAAATTCCAAACAGTACCAGTGAGAGCAGCACTTCCACTGGGGCTAGGCTTGAGACCTAAAGGCAAGTATGAAATGC
ATATGCTACTTCACTCCCTCTCCCAACCCTTAATAATGAGGCAAAGCAAGAGCCTAGTGAAGGCCAATGCTAGGTTTACAAACTTACCCA
GAAGCCTCTGCAAAGCTTCACAGGCTCCTCAGATGAAAATAACAGGAATCAATGGGGACTACGGCCAGACACTGGTTTGCCATTCTGTTC
CTTTTAAGAAGTAACAGTGCTGCAAGGAAGTCCATGTCAGAAAGCCAACAGAAGGTGATTTCCACAACTTTGAACAGGTTGTTACAAGTA
TCAGCAAGAATGTGTCCTTTTCAGAAATAACAGTCAAATCAAAGAAGGTTAATAAAGGCTTTAATTTCATACACACAAAAAAACTCTATG
CATAATTTAAAAAGGAAACAAAAACAAAGAAAAACCGTAAAGGATACAGAGGAACAGTTCTGCTAAAACACAGATAAAAGTGCCGCTCCA
TACAAAACATAAAGAATCAGAATCAAAAGTCACTCTGAACATAAAGAAAAAAAATCATCTCACAAATAATGTGGCCACAGCTGCCAGAAA
ACCTGGTAGTGGCTCAATTAGGCAAAGTGTAGGAATCTCATTTTTGTTTTTCTCTCCTTAAGTTTAAAGAAACAACAATGACAATAGGCC
AGAGAAGTTAGGGAGGGAAAGAAAAGCTCAAAGGGAGGGAAACCTGGGGACAAGAGGTGTGCACACCCACATGTGGTCTCACTCTTCACA
CAGGCCCACTATTTTTGAAGTAGACCAGTTTAGTTGACTGTTCTTCTTTGTTCTGGCATCTGACTGGACCAACCTGGAACCTGGTCCAGA
CCCTCACCCACTCTATTCTTATGCCAATGGACATACCTATACTTTGAACCTCTGTACTTTTAAGAAAAGTCCAATGTTACAAAATCAAAT
GCTTATATTCAGACTGGCACACTTTTTAAATAAAAACTCCATACACCTCAGACATATAGCACACATGGAGACAACTTACTAATTGTGTGT
AAGTATGATACAATGAATGAGACTGCCTGAAGTCTAGTAATCAAAGCATGCCATAAGGTGAATGATTGTGGTTAAACACAGCAAAATAAT
TGTCACAAAACTTTCAAGGCCTAACAAATTAGAATTTTCCAATAAAAAATATATATTTTTTCAGATGTTAATAAGACATATCAGTAGAGA
CAAAATTAGGATTTTGAAGTAATGCAATAAAAAGATGTTGGAGGGCAGAAGTCTATTTAGTTTTTGTATACACTTGCAAGAGTGCATTAC
TCAGTATAAAGCAAAATGGGGAGGAAAAAGACATCCATCCATTTTATTGGAACACTTTTATGTGACTTGAATCTGGTGTTAGGTTGTTGA
TTTTTCTAAAAATCTCCTATATATACAAAATCCATATGTACTTGGAGATCCAGCTGTTGCCCCCTGTTTAAAACAAAAGACCACCTCGGG
GGGTCAATTAAATTAAAAAGGCCCTCCAACCACCCTAAATGGGATAACTAAGAGTATCTACTGCAGTCATTTCAGAGGACAGAGAAGGAA
AATATTTTAATTTGCTTTAATATAACCTCTTTTCAGTAGATCACAAATGAGTTTACAAACTACTTTTTTTTCTCTTTAATTTAGGTGTTT
GCAGATAATTTTCATTATATCCGTAGCTGTATGTGTGTATAGTTACATAATGGTAACTACACACGATACAGAAGAATCAGTAAATTCATG
GATTATTTTGCTGAGGTTTTAAATTTTAAAGCCTCTGTTTCAGAATTTTATACTTGATCAAGGAGAAAAATAAATGTGTAGTCTAACATT
TGCTTTCTGGAGTTAATTAACTGATCTGTAAGAACCACTGCATATGTCTTAAAATGTAAACATATTTACATTTGTTGTATTTGTTATTGA
GCCTTTAAGGTTAGGCCCAGAATGAACAGACCATAGCAAGTAAACAAATAATTTTTAGAATCAAAGTATTAATAGAAGACCAGTTCATGG
ATTTGCTTATTCTATCCTGCTGAGACAAAACTCATGAGTGTGCACACACATGTGAATATATCCCTACGAAACAGTCTATCTTCTCATAGG
CTTAAATTATAGTCATGGCTATTAAAGAAATTAACAGCATCCAGCCACATGCAACTTTCCAACCTTCAGTACTATTAGGTGATTAAAATC
AACAAATATGAAGTTTAGTTCATTTTTCCCTTAAAATTCCAACAAAGATCAAAAGGTTGTATCTAGAACTAATTGCCATCAAGTTCCAAT
TCAATGTCATTTAAAGTAATGTAACCACACATTTGGTATTTTCAATAGGAAGGTTAATTAGGTATTGTGCAAACTGCCTGCAACGGAAGC
ACTCAGTCCTTATCTAACTTGTCCCTTCCTGGCCCCAACATGCTAACTGCCCCATCCCCAATTCTGGGCAAACTGATCACAATGTGCAAA
AAATAATATATTATCTATTTATAATTTTAAAATATATACAGCCAGCTCAAAAACAACAACAAACCCCATCAACATAGTCCAGCTGAAATC
TCCACTGGTAGTCAAAGAAGTAGATTAAAGGAGTAAAGGAAGGAGAAGGCTGATAGGGCCACAAGAATGGACAGACATCAAGTAAAATTT
GAGTCCCAAACATGCAAGTACATGAGCAGTGAGATAACTTATATATTCCAATAACCTATTTTCAACAACTCCTGCCCAAGACATGAAGAT
CAAATCAGGTTTCTGAGGTAAGTGTACTTCTAAACCATACACACATGAAAGCTATGAAAGCAATTCAAATGAGGCTGCTTCATGAGGCAA
TCTAGACTTATGGCATTATTTCTACTTTTCTCCATGTTTTAATTGCAGCCTGCACTTTAAATCTTTCCCAATAATTTTTAACAGTGCCTC
TCAAATGCAAAGACACGTAAAAGAATTAATAACTAGCCAAAGAATTTTATCACCGCTTCACTCATTTATAAGAAAACCAATTATTTCCAA
GCAAAATCAAACCAAACCAAAGAGGCTCCTGGTAGAAATGAAACAAAACTTTAAAGCTAGTTTTAAAACAAATATTTTCCTCTGCTCTAA
ACTACTCTGGCGTTTTCTACCACTCTACCATTTTGGAACATTCATTACAATAAGGTATATAGGTAGATGGTAGGAGGCAAAGCATTTATC
AGTAGTTGAGCAAAACTGCTGAGGCCATTTATAATTCAAAGAATGAAAACTTAGAATAGTTTACTACATTAGAATACATCCAAGTTCCAA
GAGTAGGACTGGAGCTCTCTTAAGGCAATCTTTCAGAAAAGATGTTGCATCTTCTGTGATGATGGTTTGTGTTTTTTTTGTTTTTGTTTT

>2315_2315_5_ADD3-VIL1_ADD3_chr10_111877180_ENST00000360162_VIL1_chr2_219305444_ENST00000248444_length(amino acids)=273AA_BP=189
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLEVTSPKVDVFNANSNLSSGPLPIFPLEQLVNKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKEK

--------------------------------------------------------------
>2315_2315_6_ADD3-VIL1_ADD3_chr10_111877180_ENST00000360162_VIL1_chr2_219305444_ENST00000392114_length(transcript)=1387nt_BP=944nt
AGTCCACAAAACTCCCTGATTCCATCCTCTCTGCCTCTTATGAAGCAATACTAGAGAGGAAAAACAAAACCCATTCCTTTAAGAAAGATT
CCGCCTCCTCTCATAAGCAAGCGCCTAATGGTAATTGTAGAGTTTACTAAGTCAAACACTTACTACTCAGCATTGAGAGAAGCTGCTGCT
GCTAATGCTGCTGCTGCTGCTGCCGCCGCCGCCGCTGCTGCTGCTGCTGTTGGTCTGAGGCTGCAGTAGGTTTCTGTGCAGCATTGCAGA
ATCCACACCTAGAGAACAGAAGACACAGACACGTACGTCTACTACCCTTGTTAGAAGGAAGCTTTGGATCTTCGGTGGATAACAAGAGTA
ATCCACAGACTTAAAACATGAGCTCAGATGCCAGCCAAGGCGTGATTACCACTCCTCCTCCTCCCAGCATGCCTCACAAAGAGAGATATT
TTGACCGCATCAATGAAAATGACCCAGAATACATTAGGGAGAGGAACATGTCTCCTGATCTACGACAAGACTTCAACATGATGGAGCAGA
GGAAACGAGTTACTCAGATCCTGCAAAGTCCTGCCTTTCGGGAAGACTTGGAATGCCTTATTCAAGAACAGATGAAGAAAGGCCACAACC
CAACTGGATTACTAGCATTACAGCAGATTGCAGATTACATCATGGCCAATTCTTTCTCGGGTTTTTCTTCACCTCCTCTCAGTCTTGGCA
TGGTCACACCTATCAATGACCTTCCTGGTGCAGATACATCCTCATATGTGAAGGGAGAAAAACTTACTCGCTGTAAACTTGCCAGCCTGT
ACAGACTTGTAGACTTGTTTGGATGGGCACACCTGGCAAATACCTATATCTCAGTAAGAATAAGTAAGGAGCAAGACCACATTATAATAA
TTCCCAGAGGCCTATCTTTTTCTGAAGCTACAGCCTCCAATTTGGAGGTCACAAGCCCCAAAGTGGACGTGTTCAATGCTAACAGCAACC
TCAGTTCTGGGCCTCTGCCCATCTTCCCCCTGGAGCAGCTAGTGAACAAGCCTGTAGAGGAGCTCCCCGAGGGTGTGGACCCCAGCAGGA
AGGAGGAACACCTGTCCATTGAAGATTTCACTCAGGCCTTTGGGATGACTCCAGCTGCCTTCTCTGCTCTGCCTCGATGGAAGCAACAAA
ACCTCAAGAAAGAAAAAGGACTATTTTGAGAAGAGTAGCTGTGGTTGTAAAGCAGTACCCTACCCTGATTGTAGGGTCTCATTTTCTCAC
CGATATTAGTCCTACACCAATTGAAGTGAAATTTTGCAGATGTGCCTATGAGCACAAACTTCTGTGGCAAATGCCAGTTTTGTTTAATAA

>2315_2315_6_ADD3-VIL1_ADD3_chr10_111877180_ENST00000360162_VIL1_chr2_219305444_ENST00000392114_length(amino acids)=273AA_BP=189
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLEVTSPKVDVFNANSNLSSGPLPIFPLEQLVNKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKEK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ADD3-VIL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneADD3chr10:111877180chr2:219305444ENST00000277900+514684_701189.0675.0calmodulin
HgeneADD3chr10:111877180chr2:219305444ENST00000356080+515684_701189.0707.0calmodulin
HgeneADD3chr10:111877180chr2:219305444ENST00000360162+514684_701189.0675.0calmodulin


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADD3-VIL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADD3-VIL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADD3C0005586Bipolar Disorder1CTD_human
HgeneADD3C0005587Depression, Bipolar1CTD_human
HgeneADD3C0007786Brain Ischemia1CTD_human
HgeneADD3C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneADD3C0024713Manic Disorder1CTD_human
HgeneADD3C0149504Encephalopathy, Toxic1CTD_human
HgeneADD3C0154659Toxic Encephalitis1CTD_human
HgeneADD3C0235032Neurotoxicity Syndromes1CTD_human
HgeneADD3C0338831Manic1CTD_human
HgeneADD3C0917798Cerebral Ischemia1CTD_human
HgeneADD3C2751938Cerebral Palsy, Spastic Quadriplegic, 11ORPHANET
HgeneADD3C4310767CEREBRAL PALSY, SPASTIC QUADRIPLEGIC, 31CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0008370Cholestasis1CTD_human