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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:DIS3L2-WDR75 (FusionGDB2 ID:HG129563TG84128) |
Fusion Gene Summary for DIS3L2-WDR75 |
Fusion gene summary |
Fusion gene information | Fusion gene name: DIS3L2-WDR75 | Fusion gene ID: hg129563tg84128 | Hgene | Tgene | Gene symbol | DIS3L2 | WDR75 | Gene ID | 129563 | 84128 |
Gene name | DIS3 like 3'-5' exoribonuclease 2 | WD repeat domain 75 | |
Synonyms | FAM6A|PRLMNS|hDIS3L2 | NET16|UTP17 | |
Cytomap | ('DIS3L2')('WDR75') 2q37.1 | 2q32.2 | |
Type of gene | protein-coding | protein-coding | |
Description | DIS3-like exonuclease 2DIS3 mitotic control homolog-like 2family with sequence similarity 6, member A | WD repeat-containing protein 75U3 small nucleolar RNA-associated protein 17 homologUTP17, small subunit (SSU) processome component, homolog | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000273009, ENST00000325385, ENST00000409307, ENST00000360410, ENST00000409401, ENST00000470087, | ||
Fusion gene scores | * DoF score | 27 X 9 X 12=2916 | 4 X 4 X 2=32 |
# samples | 25 | 5 | |
** MAII score | log2(25/2916*10)=-3.54399071966485 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/32*10)=0.643856189774725 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: DIS3L2 [Title/Abstract] AND WDR75 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | DIS3L2(233028342)-WDR75(190313104), # samples:1 DIS3L2(233028342)-WDR75(190313105), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DIS3L2 | GO:0010587 | miRNA catabolic process | 24141620 |
Fusion gene breakpoints across DIS3L2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across WDR75 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-BR-A4J9-01A | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313105 | + |
ChimerDB4 | STAD | TCGA-BR-A4J9 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313104 | + |
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Fusion Gene ORF analysis for DIS3L2-WDR75 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000273009 | ENST00000314761 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313105 | + |
In-frame | ENST00000273009 | ENST00000314761 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313104 | + |
In-frame | ENST00000325385 | ENST00000314761 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313105 | + |
In-frame | ENST00000325385 | ENST00000314761 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313104 | + |
In-frame | ENST00000409307 | ENST00000314761 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313105 | + |
In-frame | ENST00000409307 | ENST00000314761 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313104 | + |
intron-3CDS | ENST00000360410 | ENST00000314761 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313105 | + |
intron-3CDS | ENST00000360410 | ENST00000314761 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313104 | + |
intron-3CDS | ENST00000409401 | ENST00000314761 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313105 | + |
intron-3CDS | ENST00000409401 | ENST00000314761 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313104 | + |
intron-3CDS | ENST00000470087 | ENST00000314761 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313105 | + |
intron-3CDS | ENST00000470087 | ENST00000314761 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313104 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000273009 | DIS3L2 | chr2 | 233028342 | + | ENST00000314761 | WDR75 | chr2 | 190313104 | + | 4293 | 1738 | 578 | 4144 | 1188 |
ENST00000325385 | DIS3L2 | chr2 | 233028342 | + | ENST00000314761 | WDR75 | chr2 | 190313104 | + | 3955 | 1400 | 240 | 3806 | 1188 |
ENST00000409307 | DIS3L2 | chr2 | 233028342 | + | ENST00000314761 | WDR75 | chr2 | 190313104 | + | 3679 | 1124 | 0 | 3530 | 1176 |
ENST00000273009 | DIS3L2 | chr2 | 233028342 | + | ENST00000314761 | WDR75 | chr2 | 190313105 | + | 4293 | 1738 | 578 | 4144 | 1188 |
ENST00000325385 | DIS3L2 | chr2 | 233028342 | + | ENST00000314761 | WDR75 | chr2 | 190313105 | + | 3955 | 1400 | 240 | 3806 | 1188 |
ENST00000409307 | DIS3L2 | chr2 | 233028342 | + | ENST00000314761 | WDR75 | chr2 | 190313105 | + | 3679 | 1124 | 0 | 3530 | 1176 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000273009 | ENST00000314761 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313104 | + | 0.000603145 | 0.9993968 |
ENST00000325385 | ENST00000314761 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313104 | + | 0.00035601 | 0.99964404 |
ENST00000409307 | ENST00000314761 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313104 | + | 0.000225574 | 0.9997744 |
ENST00000273009 | ENST00000314761 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313105 | + | 0.000603145 | 0.9993968 |
ENST00000325385 | ENST00000314761 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313105 | + | 0.00035601 | 0.99964404 |
ENST00000409307 | ENST00000314761 | DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313105 | + | 0.000225574 | 0.9997744 |
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Fusion Genomic Features for DIS3L2-WDR75 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313104 | + | 2.27E-06 | 0.99999774 |
DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313104 | + | 2.27E-06 | 0.99999774 |
DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313104 | + | 2.27E-06 | 0.99999774 |
DIS3L2 | chr2 | 233028342 | + | WDR75 | chr2 | 190313104 | + | 2.27E-06 | 0.99999774 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for DIS3L2-WDR75 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:233028342/chr2:190313104) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | WDR75 | chr2:233028342 | chr2:190313104 | ENST00000314761 | 0 | 21 | 145_184 | 28 | 831.0 | Repeat | Note=WD 4 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313104 | ENST00000314761 | 0 | 21 | 193_231 | 28 | 831.0 | Repeat | Note=WD 5 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313104 | ENST00000314761 | 0 | 21 | 237_276 | 28 | 831.0 | Repeat | Note=WD 6 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313104 | ENST00000314761 | 0 | 21 | 279_318 | 28 | 831.0 | Repeat | Note=WD 7 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313104 | ENST00000314761 | 0 | 21 | 324_362 | 28 | 831.0 | Repeat | Note=WD 8 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313104 | ENST00000314761 | 0 | 21 | 376_423 | 28 | 831.0 | Repeat | Note=WD 9 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313104 | ENST00000314761 | 0 | 21 | 430_474 | 28 | 831.0 | Repeat | Note=WD 10 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313104 | ENST00000314761 | 0 | 21 | 47_86 | 28 | 831.0 | Repeat | Note=WD 2 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313104 | ENST00000314761 | 0 | 21 | 487_525 | 28 | 831.0 | Repeat | Note=WD 11 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313104 | ENST00000314761 | 0 | 21 | 529_569 | 28 | 831.0 | Repeat | Note=WD 12 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313104 | ENST00000314761 | 0 | 21 | 574_611 | 28 | 831.0 | Repeat | Note=WD 13 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313104 | ENST00000314761 | 0 | 21 | 90_131 | 28 | 831.0 | Repeat | Note=WD 3 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313105 | ENST00000314761 | 0 | 21 | 145_184 | 28 | 831.0 | Repeat | Note=WD 4 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313105 | ENST00000314761 | 0 | 21 | 193_231 | 28 | 831.0 | Repeat | Note=WD 5 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313105 | ENST00000314761 | 0 | 21 | 237_276 | 28 | 831.0 | Repeat | Note=WD 6 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313105 | ENST00000314761 | 0 | 21 | 279_318 | 28 | 831.0 | Repeat | Note=WD 7 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313105 | ENST00000314761 | 0 | 21 | 324_362 | 28 | 831.0 | Repeat | Note=WD 8 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313105 | ENST00000314761 | 0 | 21 | 376_423 | 28 | 831.0 | Repeat | Note=WD 9 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313105 | ENST00000314761 | 0 | 21 | 430_474 | 28 | 831.0 | Repeat | Note=WD 10 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313105 | ENST00000314761 | 0 | 21 | 47_86 | 28 | 831.0 | Repeat | Note=WD 2 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313105 | ENST00000314761 | 0 | 21 | 487_525 | 28 | 831.0 | Repeat | Note=WD 11 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313105 | ENST00000314761 | 0 | 21 | 529_569 | 28 | 831.0 | Repeat | Note=WD 12 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313105 | ENST00000314761 | 0 | 21 | 574_611 | 28 | 831.0 | Repeat | Note=WD 13 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313105 | ENST00000314761 | 0 | 21 | 90_131 | 28 | 831.0 | Repeat | Note=WD 3 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | WDR75 | chr2:233028342 | chr2:190313104 | ENST00000314761 | 0 | 21 | 4_43 | 28 | 831.0 | Repeat | Note=WD 1 | |
Tgene | WDR75 | chr2:233028342 | chr2:190313105 | ENST00000314761 | 0 | 21 | 4_43 | 28 | 831.0 | Repeat | Note=WD 1 |
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Fusion Gene Sequence for DIS3L2-WDR75 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>22925_22925_1_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000273009_WDR75_chr2_190313104_ENST00000314761_length(transcript)=4293nt_BP=1738nt ATGCGGGGGTTGTCCATCTCTGTATCCCCAGTGCCAGCACTGCACCTCGCCCCAAGCAGTTGTCCAATAAATGAGCAGTGAGTAAATGAA AGAATGAGCAAAGCCTTGTAACAGGAAAGGGGCCGGCGGCGTCTGCCGTGCAAGACCTGGCCCAGTGGAGCAGAGCCTGGAGGTTCAGGA GCCGGGTCTGGAAGGCTCCTTCCGGTGGAAGAGGGGCCCGGAGCCAGCCGGCGCCTGGCACAAGGCGTCTCAGAGGCCGCCCACTGGGAG CCAACCGTTGCAGCCAGTTGTCCCCGCGAGCGAGGCCGGAGAAGGCGCGGCGGCCCCTGGCCTGGCCATTTCGCCCTTGTCGCAGCTGAA CCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCACCGTCGCTCTCTAGAACGCCGCG CCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAAACGCGAATGACAACAGAGCTGC TCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAGCCAATAATGAGCCATCCTGACT ACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCTTCGCCAGGTGACAAAA AGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCAGAAGGCTTGAAGAGAG GAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGTGATCGAGACATTTTTA TTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCATTGGAAGGTAGTTAAAC CAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTCCCGCAACAGTCCCTGA AAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGCATCACACAAAATGTGC TGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACAAAAGATGAGACCACCT GCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAGAAAAAACATTCTCGAG CAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCCTCAGACCACCGAGTGC CTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTGTTCATCTGCCGCATTG TGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAGCCTGAAACAGAAGGAA TACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCATGGACAATTCCACCAG AGGAGTTCAGCAAGAGAAGGGATTTAAGGTATATCTTCTGTGTCTCTGGAGACTTTGTTAAAGTTTACAGCACAGTTACAGAAGAGTGTG TACACATACTGCATGGACACAGAAATCTGGTGACTGGAATCCAGCTTAACCCCAACAACCATCTACAGCTGTATTCTTGTTCCCTTGATG GCACAATTAAACTGTGGGACTATATAGATGGCATCTTAATAAAGACTTTCATAGTTGGATGTAAACTTCATGCCCTCTTTACTCTTGCCC AAGCTGAGGATTCTGTCTTTGTTATAGTGAATAAAGAAAAACCAGATATATTTCAGCTGGTTTCAGTGAAACTGCCAAAATCCTCAAGCC AGGAAGTAGAAGCCAAGGAGCTGTCCTTTGTTTTGGATTACATAAACCAGTCACCCAAGTGCATTGCCTTTGGAAACGAGGGAGTATATG TTGCTGCAGTACGGGAATTTTACTTGTCTGTTTATTTTTTCAAAAAGAAAACAACATCAAGGTTTACTTTATCATCATCAAGAAATAAGA AGCATGCTAAAAACAATTTTACATGTGTAGCATGTCACCCAACGGAAGACTGCATCGCATCTGGTCACATGGATGGCAAAATTCGTCTTT GGAGGAATTTTTATGATGATAAGAAATATACGTACACATGTTTACATTGGCACCATGATATGGTTATGGATTTGGCTTTTTCAGTGACAG GCACCAGTCTGCTGAGTGGCGGTCGTGAATCTGTACTTGTAGAGTGGCGCGATGCAACAGAGAAGAATAAGGAGTTTCTCCCGCGTTTAG GAGCTACTATTGAACATATCTCAGTCTCGCCTGCAGGAGATTTATTCTGCACTTCTCACTCTGATAATAAGATAATAATTATTCACCGAA ACCTTGAAGCATCCGCAGTAATTCAAGGCCTAGTGAAAGATAGGAGTATCTTCACTGGTTTGATGATTGATCCAAGAACTAAAGCTTTGG TTTTGAATGGAAAACCTGGCCACCTGCAGTTTTATTCTCTCCAGAGTGATAAACAGTTATACAATTTAGATATTATACAGCAAGAATATA TTAATGATTATGGTCTGATCCAAATTGAACTAACAAAGGCTGCATTTGGCTGCTTTGGTAACTGGCTTGCAACAGTGGAACAGCGGCAAG AAAAGGAAACTGAGCTTGAATTGCAAATGAAACTGTGGATGTATAATAAGAAAACACAAGGGTTTATTCTTAACACTAAAATTAACATGC CACACGAAGACTGCATTACAGCTCTCTGTTTCTGTAATGCAGAAAAATCTGAACAGCCCACCTTGGTTACAGCTAGCAAAGATGGTTACT TCAAAGTATGGATATTAACAGATGACTCTGACATATACAAAAAAGCTGTTGGCTGGACCTGTGACTTTGTTGGTAGTTATCACAAGTATC AAGCAACTAACTGTTGTTTCTCCGAAGATGGTTCTTTACTAGCAGTTAGTTTTGAGGAAATAGTCACAATATGGGATTCTGTAACATGGG AACTTAAATGTACATTTTGCCAACGAGCTGGGAAAATAAGGCACCTTTGCTTTGGGAGATTGACGTGTTCAAAGTATCTACTTGGTGCTA CTGAAAATGGCATTCTTTGCTGTTGGAATCTGCTGAGCTGTGCATTGGAGTGGAATGCAAAATTAAATGTTAGAGTTATGGAACCCGATC CTAATTCAGAGAATATTGCTGCAATCTCTCAGTCTTCAGTGGGTTCAGACTTGTTTGTATTTAAACCTAGTGAGCCAAGGCCATTGTATA TTCAAAAGGGTATCTCCAGAGAGAAAGTCCAGTGGGGAGTGTTTGTTCCACGAGATGTCCCTGAATCCTTCACCTCAGAAGCTTACCAGT GGCTAAATAGATCCCAGTTTTACTTCCTAACAAAATCACAGAGTTTATTGACATTCAGTACAAAGTCTCCAGAAGAAAAACTCACACCAA CAAGCAAACAGCTGCTAGCAGAAGAAAGTCTTCCCACAACCCCATTTTATTTCATATTGGGAAAACACAGGCAACAGCAGGATGAAAAAC TAAACGAAACTTTAGAGAATGAGCTGGTACAACTACCCTTAACAGAAAACATACCCGCAATTAGTGAGCTTCTTCACACTCCAGCCCATG TCCTGCCATCTGCTGCTTTCCTGTGCTCCATGTTTGTAAATTCATTGCTGCTGTCTAAAGAGACTAAGAGTGCTAAGGAAATTCCTGAAG ATGTAGATATGGAAGAAGAAAAAGAAAGTGAAGATTCAGATGAAGAAAATGATTTTACCGAAAAAGTCCAGGATACAAGTAACACAGGTT TAGGAGAAGACATTATACATCAGTTGTCAAAATCTGAAGAAAAAGAACTGAGAAAATTTAGGAAAATAGACTACAGCTGGATAGCTGCCC TTTAAGCCTTGGAGATGGGGAGGATCCTTGGACTTTGTGTTTTTGATTGTATGTTGATATTCTAAAAACATCTATTTTAATGTTATTTCT >22925_22925_1_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000273009_WDR75_chr2_190313104_ENST00000314761_length(amino acids)=1188AA_BP=386 MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS SEVLECLPQGLPWTIPPEEFSKRRDLRYIFCVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGIL IKTFIVGCKLHALFTLAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSVYF FKKKTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVL VEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYS LQSDKQLYNLDIIQQEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMKLWMYNKKTQGFILNTKINMPHEDCITALCFCN AEKSEQPTLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAGKI RHLCFGRLTCSKYLLGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQSSVGSDLFVFKPSEPRPLYIQKGISREKVQWG VFVPRDVPESFTSEAYQWLNRSQFYFLTKSQSLLTFSTKSPEEKLTPTSKQLLAEESLPTTPFYFILGKHRQQQDEKLNETLENELVQLP LTENIPAISELLHTPAHVLPSAAFLCSMFVNSLLLSKETKSAKEIPEDVDMEEEKESEDSDEENDFTEKVQDTSNTGLGEDIIHQLSKSE -------------------------------------------------------------- >22925_22925_2_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000273009_WDR75_chr2_190313105_ENST00000314761_length(transcript)=4293nt_BP=1738nt ATGCGGGGGTTGTCCATCTCTGTATCCCCAGTGCCAGCACTGCACCTCGCCCCAAGCAGTTGTCCAATAAATGAGCAGTGAGTAAATGAA AGAATGAGCAAAGCCTTGTAACAGGAAAGGGGCCGGCGGCGTCTGCCGTGCAAGACCTGGCCCAGTGGAGCAGAGCCTGGAGGTTCAGGA GCCGGGTCTGGAAGGCTCCTTCCGGTGGAAGAGGGGCCCGGAGCCAGCCGGCGCCTGGCACAAGGCGTCTCAGAGGCCGCCCACTGGGAG CCAACCGTTGCAGCCAGTTGTCCCCGCGAGCGAGGCCGGAGAAGGCGCGGCGGCCCCTGGCCTGGCCATTTCGCCCTTGTCGCAGCTGAA CCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCACCGTCGCTCTCTAGAACGCCGCG CCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAAACGCGAATGACAACAGAGCTGC TCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAGCCAATAATGAGCCATCCTGACT ACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCTTCGCCAGGTGACAAAA AGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCAGAAGGCTTGAAGAGAG GAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGTGATCGAGACATTTTTA TTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCATTGGAAGGTAGTTAAAC CAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTCCCGCAACAGTCCCTGA AAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGCATCACACAAAATGTGC TGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACAAAAGATGAGACCACCT GCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAGAAAAAACATTCTCGAG CAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCCTCAGACCACCGAGTGC CTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTGTTCATCTGCCGCATTG TGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAGCCTGAAACAGAAGGAA TACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCATGGACAATTCCACCAG AGGAGTTCAGCAAGAGAAGGGATTTAAGGTATATCTTCTGTGTCTCTGGAGACTTTGTTAAAGTTTACAGCACAGTTACAGAAGAGTGTG TACACATACTGCATGGACACAGAAATCTGGTGACTGGAATCCAGCTTAACCCCAACAACCATCTACAGCTGTATTCTTGTTCCCTTGATG GCACAATTAAACTGTGGGACTATATAGATGGCATCTTAATAAAGACTTTCATAGTTGGATGTAAACTTCATGCCCTCTTTACTCTTGCCC AAGCTGAGGATTCTGTCTTTGTTATAGTGAATAAAGAAAAACCAGATATATTTCAGCTGGTTTCAGTGAAACTGCCAAAATCCTCAAGCC AGGAAGTAGAAGCCAAGGAGCTGTCCTTTGTTTTGGATTACATAAACCAGTCACCCAAGTGCATTGCCTTTGGAAACGAGGGAGTATATG TTGCTGCAGTACGGGAATTTTACTTGTCTGTTTATTTTTTCAAAAAGAAAACAACATCAAGGTTTACTTTATCATCATCAAGAAATAAGA AGCATGCTAAAAACAATTTTACATGTGTAGCATGTCACCCAACGGAAGACTGCATCGCATCTGGTCACATGGATGGCAAAATTCGTCTTT GGAGGAATTTTTATGATGATAAGAAATATACGTACACATGTTTACATTGGCACCATGATATGGTTATGGATTTGGCTTTTTCAGTGACAG GCACCAGTCTGCTGAGTGGCGGTCGTGAATCTGTACTTGTAGAGTGGCGCGATGCAACAGAGAAGAATAAGGAGTTTCTCCCGCGTTTAG GAGCTACTATTGAACATATCTCAGTCTCGCCTGCAGGAGATTTATTCTGCACTTCTCACTCTGATAATAAGATAATAATTATTCACCGAA ACCTTGAAGCATCCGCAGTAATTCAAGGCCTAGTGAAAGATAGGAGTATCTTCACTGGTTTGATGATTGATCCAAGAACTAAAGCTTTGG TTTTGAATGGAAAACCTGGCCACCTGCAGTTTTATTCTCTCCAGAGTGATAAACAGTTATACAATTTAGATATTATACAGCAAGAATATA TTAATGATTATGGTCTGATCCAAATTGAACTAACAAAGGCTGCATTTGGCTGCTTTGGTAACTGGCTTGCAACAGTGGAACAGCGGCAAG AAAAGGAAACTGAGCTTGAATTGCAAATGAAACTGTGGATGTATAATAAGAAAACACAAGGGTTTATTCTTAACACTAAAATTAACATGC CACACGAAGACTGCATTACAGCTCTCTGTTTCTGTAATGCAGAAAAATCTGAACAGCCCACCTTGGTTACAGCTAGCAAAGATGGTTACT TCAAAGTATGGATATTAACAGATGACTCTGACATATACAAAAAAGCTGTTGGCTGGACCTGTGACTTTGTTGGTAGTTATCACAAGTATC AAGCAACTAACTGTTGTTTCTCCGAAGATGGTTCTTTACTAGCAGTTAGTTTTGAGGAAATAGTCACAATATGGGATTCTGTAACATGGG AACTTAAATGTACATTTTGCCAACGAGCTGGGAAAATAAGGCACCTTTGCTTTGGGAGATTGACGTGTTCAAAGTATCTACTTGGTGCTA CTGAAAATGGCATTCTTTGCTGTTGGAATCTGCTGAGCTGTGCATTGGAGTGGAATGCAAAATTAAATGTTAGAGTTATGGAACCCGATC CTAATTCAGAGAATATTGCTGCAATCTCTCAGTCTTCAGTGGGTTCAGACTTGTTTGTATTTAAACCTAGTGAGCCAAGGCCATTGTATA TTCAAAAGGGTATCTCCAGAGAGAAAGTCCAGTGGGGAGTGTTTGTTCCACGAGATGTCCCTGAATCCTTCACCTCAGAAGCTTACCAGT GGCTAAATAGATCCCAGTTTTACTTCCTAACAAAATCACAGAGTTTATTGACATTCAGTACAAAGTCTCCAGAAGAAAAACTCACACCAA CAAGCAAACAGCTGCTAGCAGAAGAAAGTCTTCCCACAACCCCATTTTATTTCATATTGGGAAAACACAGGCAACAGCAGGATGAAAAAC TAAACGAAACTTTAGAGAATGAGCTGGTACAACTACCCTTAACAGAAAACATACCCGCAATTAGTGAGCTTCTTCACACTCCAGCCCATG TCCTGCCATCTGCTGCTTTCCTGTGCTCCATGTTTGTAAATTCATTGCTGCTGTCTAAAGAGACTAAGAGTGCTAAGGAAATTCCTGAAG ATGTAGATATGGAAGAAGAAAAAGAAAGTGAAGATTCAGATGAAGAAAATGATTTTACCGAAAAAGTCCAGGATACAAGTAACACAGGTT TAGGAGAAGACATTATACATCAGTTGTCAAAATCTGAAGAAAAAGAACTGAGAAAATTTAGGAAAATAGACTACAGCTGGATAGCTGCCC TTTAAGCCTTGGAGATGGGGAGGATCCTTGGACTTTGTGTTTTTGATTGTATGTTGATATTCTAAAAACATCTATTTTAATGTTATTTCT >22925_22925_2_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000273009_WDR75_chr2_190313105_ENST00000314761_length(amino acids)=1188AA_BP=386 MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS SEVLECLPQGLPWTIPPEEFSKRRDLRYIFCVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGIL IKTFIVGCKLHALFTLAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSVYF FKKKTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVL VEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYS LQSDKQLYNLDIIQQEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMKLWMYNKKTQGFILNTKINMPHEDCITALCFCN AEKSEQPTLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAGKI RHLCFGRLTCSKYLLGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQSSVGSDLFVFKPSEPRPLYIQKGISREKVQWG VFVPRDVPESFTSEAYQWLNRSQFYFLTKSQSLLTFSTKSPEEKLTPTSKQLLAEESLPTTPFYFILGKHRQQQDEKLNETLENELVQLP LTENIPAISELLHTPAHVLPSAAFLCSMFVNSLLLSKETKSAKEIPEDVDMEEEKESEDSDEENDFTEKVQDTSNTGLGEDIIHQLSKSE -------------------------------------------------------------- >22925_22925_3_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000325385_WDR75_chr2_190313104_ENST00000314761_length(transcript)=3955nt_BP=1400nt TTTCGCCCTTGTCGCAGCTGAACCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCAC CGTCGCTCTCTAGAACGCCGCGCCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAA ACGCGAATGACAACAGAGCTGCTCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAG CCAATAATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATT GGTGCTTCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGAT GTTTCAGAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCG GATGGTGATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAG GAGCATTGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACAC CATCTCCCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGA CATGGCATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCG GTTACAAAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATC TTGGAGAAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTT TCTCCCTCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAAC ACACTGTTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAA ATTGAGCCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGC CTGCCATGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGGTATATCTTCTGTGTCTCTGGAGACTTTGTTAAAGTTTAC AGCACAGTTACAGAAGAGTGTGTACACATACTGCATGGACACAGAAATCTGGTGACTGGAATCCAGCTTAACCCCAACAACCATCTACAG CTGTATTCTTGTTCCCTTGATGGCACAATTAAACTGTGGGACTATATAGATGGCATCTTAATAAAGACTTTCATAGTTGGATGTAAACTT CATGCCCTCTTTACTCTTGCCCAAGCTGAGGATTCTGTCTTTGTTATAGTGAATAAAGAAAAACCAGATATATTTCAGCTGGTTTCAGTG AAACTGCCAAAATCCTCAAGCCAGGAAGTAGAAGCCAAGGAGCTGTCCTTTGTTTTGGATTACATAAACCAGTCACCCAAGTGCATTGCC TTTGGAAACGAGGGAGTATATGTTGCTGCAGTACGGGAATTTTACTTGTCTGTTTATTTTTTCAAAAAGAAAACAACATCAAGGTTTACT TTATCATCATCAAGAAATAAGAAGCATGCTAAAAACAATTTTACATGTGTAGCATGTCACCCAACGGAAGACTGCATCGCATCTGGTCAC ATGGATGGCAAAATTCGTCTTTGGAGGAATTTTTATGATGATAAGAAATATACGTACACATGTTTACATTGGCACCATGATATGGTTATG GATTTGGCTTTTTCAGTGACAGGCACCAGTCTGCTGAGTGGCGGTCGTGAATCTGTACTTGTAGAGTGGCGCGATGCAACAGAGAAGAAT AAGGAGTTTCTCCCGCGTTTAGGAGCTACTATTGAACATATCTCAGTCTCGCCTGCAGGAGATTTATTCTGCACTTCTCACTCTGATAAT AAGATAATAATTATTCACCGAAACCTTGAAGCATCCGCAGTAATTCAAGGCCTAGTGAAAGATAGGAGTATCTTCACTGGTTTGATGATT GATCCAAGAACTAAAGCTTTGGTTTTGAATGGAAAACCTGGCCACCTGCAGTTTTATTCTCTCCAGAGTGATAAACAGTTATACAATTTA GATATTATACAGCAAGAATATATTAATGATTATGGTCTGATCCAAATTGAACTAACAAAGGCTGCATTTGGCTGCTTTGGTAACTGGCTT GCAACAGTGGAACAGCGGCAAGAAAAGGAAACTGAGCTTGAATTGCAAATGAAACTGTGGATGTATAATAAGAAAACACAAGGGTTTATT CTTAACACTAAAATTAACATGCCACACGAAGACTGCATTACAGCTCTCTGTTTCTGTAATGCAGAAAAATCTGAACAGCCCACCTTGGTT ACAGCTAGCAAAGATGGTTACTTCAAAGTATGGATATTAACAGATGACTCTGACATATACAAAAAAGCTGTTGGCTGGACCTGTGACTTT GTTGGTAGTTATCACAAGTATCAAGCAACTAACTGTTGTTTCTCCGAAGATGGTTCTTTACTAGCAGTTAGTTTTGAGGAAATAGTCACA ATATGGGATTCTGTAACATGGGAACTTAAATGTACATTTTGCCAACGAGCTGGGAAAATAAGGCACCTTTGCTTTGGGAGATTGACGTGT TCAAAGTATCTACTTGGTGCTACTGAAAATGGCATTCTTTGCTGTTGGAATCTGCTGAGCTGTGCATTGGAGTGGAATGCAAAATTAAAT GTTAGAGTTATGGAACCCGATCCTAATTCAGAGAATATTGCTGCAATCTCTCAGTCTTCAGTGGGTTCAGACTTGTTTGTATTTAAACCT AGTGAGCCAAGGCCATTGTATATTCAAAAGGGTATCTCCAGAGAGAAAGTCCAGTGGGGAGTGTTTGTTCCACGAGATGTCCCTGAATCC TTCACCTCAGAAGCTTACCAGTGGCTAAATAGATCCCAGTTTTACTTCCTAACAAAATCACAGAGTTTATTGACATTCAGTACAAAGTCT CCAGAAGAAAAACTCACACCAACAAGCAAACAGCTGCTAGCAGAAGAAAGTCTTCCCACAACCCCATTTTATTTCATATTGGGAAAACAC AGGCAACAGCAGGATGAAAAACTAAACGAAACTTTAGAGAATGAGCTGGTACAACTACCCTTAACAGAAAACATACCCGCAATTAGTGAG CTTCTTCACACTCCAGCCCATGTCCTGCCATCTGCTGCTTTCCTGTGCTCCATGTTTGTAAATTCATTGCTGCTGTCTAAAGAGACTAAG AGTGCTAAGGAAATTCCTGAAGATGTAGATATGGAAGAAGAAAAAGAAAGTGAAGATTCAGATGAAGAAAATGATTTTACCGAAAAAGTC CAGGATACAAGTAACACAGGTTTAGGAGAAGACATTATACATCAGTTGTCAAAATCTGAAGAAAAAGAACTGAGAAAATTTAGGAAAATA GACTACAGCTGGATAGCTGCCCTTTAAGCCTTGGAGATGGGGAGGATCCTTGGACTTTGTGTTTTTGATTGTATGTTGATATTCTAAAAA >22925_22925_3_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000325385_WDR75_chr2_190313104_ENST00000314761_length(amino acids)=1188AA_BP=386 MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS SEVLECLPQGLPWTIPPEEFSKRRDLRYIFCVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGIL IKTFIVGCKLHALFTLAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSVYF FKKKTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVL VEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYS LQSDKQLYNLDIIQQEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMKLWMYNKKTQGFILNTKINMPHEDCITALCFCN AEKSEQPTLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAGKI RHLCFGRLTCSKYLLGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQSSVGSDLFVFKPSEPRPLYIQKGISREKVQWG VFVPRDVPESFTSEAYQWLNRSQFYFLTKSQSLLTFSTKSPEEKLTPTSKQLLAEESLPTTPFYFILGKHRQQQDEKLNETLENELVQLP LTENIPAISELLHTPAHVLPSAAFLCSMFVNSLLLSKETKSAKEIPEDVDMEEEKESEDSDEENDFTEKVQDTSNTGLGEDIIHQLSKSE -------------------------------------------------------------- >22925_22925_4_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000325385_WDR75_chr2_190313105_ENST00000314761_length(transcript)=3955nt_BP=1400nt TTTCGCCCTTGTCGCAGCTGAACCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCAC CGTCGCTCTCTAGAACGCCGCGCCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAA ACGCGAATGACAACAGAGCTGCTCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAG CCAATAATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATT GGTGCTTCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGAT GTTTCAGAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCG GATGGTGATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAG GAGCATTGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACAC CATCTCCCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGA CATGGCATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCG GTTACAAAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATC TTGGAGAAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTT TCTCCCTCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAAC ACACTGTTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAA ATTGAGCCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGC CTGCCATGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGGTATATCTTCTGTGTCTCTGGAGACTTTGTTAAAGTTTAC AGCACAGTTACAGAAGAGTGTGTACACATACTGCATGGACACAGAAATCTGGTGACTGGAATCCAGCTTAACCCCAACAACCATCTACAG CTGTATTCTTGTTCCCTTGATGGCACAATTAAACTGTGGGACTATATAGATGGCATCTTAATAAAGACTTTCATAGTTGGATGTAAACTT CATGCCCTCTTTACTCTTGCCCAAGCTGAGGATTCTGTCTTTGTTATAGTGAATAAAGAAAAACCAGATATATTTCAGCTGGTTTCAGTG AAACTGCCAAAATCCTCAAGCCAGGAAGTAGAAGCCAAGGAGCTGTCCTTTGTTTTGGATTACATAAACCAGTCACCCAAGTGCATTGCC TTTGGAAACGAGGGAGTATATGTTGCTGCAGTACGGGAATTTTACTTGTCTGTTTATTTTTTCAAAAAGAAAACAACATCAAGGTTTACT TTATCATCATCAAGAAATAAGAAGCATGCTAAAAACAATTTTACATGTGTAGCATGTCACCCAACGGAAGACTGCATCGCATCTGGTCAC ATGGATGGCAAAATTCGTCTTTGGAGGAATTTTTATGATGATAAGAAATATACGTACACATGTTTACATTGGCACCATGATATGGTTATG GATTTGGCTTTTTCAGTGACAGGCACCAGTCTGCTGAGTGGCGGTCGTGAATCTGTACTTGTAGAGTGGCGCGATGCAACAGAGAAGAAT AAGGAGTTTCTCCCGCGTTTAGGAGCTACTATTGAACATATCTCAGTCTCGCCTGCAGGAGATTTATTCTGCACTTCTCACTCTGATAAT AAGATAATAATTATTCACCGAAACCTTGAAGCATCCGCAGTAATTCAAGGCCTAGTGAAAGATAGGAGTATCTTCACTGGTTTGATGATT GATCCAAGAACTAAAGCTTTGGTTTTGAATGGAAAACCTGGCCACCTGCAGTTTTATTCTCTCCAGAGTGATAAACAGTTATACAATTTA GATATTATACAGCAAGAATATATTAATGATTATGGTCTGATCCAAATTGAACTAACAAAGGCTGCATTTGGCTGCTTTGGTAACTGGCTT GCAACAGTGGAACAGCGGCAAGAAAAGGAAACTGAGCTTGAATTGCAAATGAAACTGTGGATGTATAATAAGAAAACACAAGGGTTTATT CTTAACACTAAAATTAACATGCCACACGAAGACTGCATTACAGCTCTCTGTTTCTGTAATGCAGAAAAATCTGAACAGCCCACCTTGGTT ACAGCTAGCAAAGATGGTTACTTCAAAGTATGGATATTAACAGATGACTCTGACATATACAAAAAAGCTGTTGGCTGGACCTGTGACTTT GTTGGTAGTTATCACAAGTATCAAGCAACTAACTGTTGTTTCTCCGAAGATGGTTCTTTACTAGCAGTTAGTTTTGAGGAAATAGTCACA ATATGGGATTCTGTAACATGGGAACTTAAATGTACATTTTGCCAACGAGCTGGGAAAATAAGGCACCTTTGCTTTGGGAGATTGACGTGT TCAAAGTATCTACTTGGTGCTACTGAAAATGGCATTCTTTGCTGTTGGAATCTGCTGAGCTGTGCATTGGAGTGGAATGCAAAATTAAAT GTTAGAGTTATGGAACCCGATCCTAATTCAGAGAATATTGCTGCAATCTCTCAGTCTTCAGTGGGTTCAGACTTGTTTGTATTTAAACCT AGTGAGCCAAGGCCATTGTATATTCAAAAGGGTATCTCCAGAGAGAAAGTCCAGTGGGGAGTGTTTGTTCCACGAGATGTCCCTGAATCC TTCACCTCAGAAGCTTACCAGTGGCTAAATAGATCCCAGTTTTACTTCCTAACAAAATCACAGAGTTTATTGACATTCAGTACAAAGTCT CCAGAAGAAAAACTCACACCAACAAGCAAACAGCTGCTAGCAGAAGAAAGTCTTCCCACAACCCCATTTTATTTCATATTGGGAAAACAC AGGCAACAGCAGGATGAAAAACTAAACGAAACTTTAGAGAATGAGCTGGTACAACTACCCTTAACAGAAAACATACCCGCAATTAGTGAG CTTCTTCACACTCCAGCCCATGTCCTGCCATCTGCTGCTTTCCTGTGCTCCATGTTTGTAAATTCATTGCTGCTGTCTAAAGAGACTAAG AGTGCTAAGGAAATTCCTGAAGATGTAGATATGGAAGAAGAAAAAGAAAGTGAAGATTCAGATGAAGAAAATGATTTTACCGAAAAAGTC CAGGATACAAGTAACACAGGTTTAGGAGAAGACATTATACATCAGTTGTCAAAATCTGAAGAAAAAGAACTGAGAAAATTTAGGAAAATA GACTACAGCTGGATAGCTGCCCTTTAAGCCTTGGAGATGGGGAGGATCCTTGGACTTTGTGTTTTTGATTGTATGTTGATATTCTAAAAA >22925_22925_4_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000325385_WDR75_chr2_190313105_ENST00000314761_length(amino acids)=1188AA_BP=386 MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS SEVLECLPQGLPWTIPPEEFSKRRDLRYIFCVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGIL IKTFIVGCKLHALFTLAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSVYF FKKKTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVL VEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYS LQSDKQLYNLDIIQQEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMKLWMYNKKTQGFILNTKINMPHEDCITALCFCN AEKSEQPTLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAGKI RHLCFGRLTCSKYLLGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQSSVGSDLFVFKPSEPRPLYIQKGISREKVQWG VFVPRDVPESFTSEAYQWLNRSQFYFLTKSQSLLTFSTKSPEEKLTPTSKQLLAEESLPTTPFYFILGKHRQQQDEKLNETLENELVQLP LTENIPAISELLHTPAHVLPSAAFLCSMFVNSLLLSKETKSAKEIPEDVDMEEEKESEDSDEENDFTEKVQDTSNTGLGEDIIHQLSKSE -------------------------------------------------------------- >22925_22925_5_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000409307_WDR75_chr2_190313104_ENST00000314761_length(transcript)=3679nt_BP=1124nt ATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCT TCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCA GAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGT GATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCAT TGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTC CCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGC ATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACA AAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAG AAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCC TCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTG TTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAG CCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCA TGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGGTATATCTTCTGTGTCTCTGGAGACTTTGTTAAAGTTTACAGCACA GTTACAGAAGAGTGTGTACACATACTGCATGGACACAGAAATCTGGTGACTGGAATCCAGCTTAACCCCAACAACCATCTACAGCTGTAT TCTTGTTCCCTTGATGGCACAATTAAACTGTGGGACTATATAGATGGCATCTTAATAAAGACTTTCATAGTTGGATGTAAACTTCATGCC CTCTTTACTCTTGCCCAAGCTGAGGATTCTGTCTTTGTTATAGTGAATAAAGAAAAACCAGATATATTTCAGCTGGTTTCAGTGAAACTG CCAAAATCCTCAAGCCAGGAAGTAGAAGCCAAGGAGCTGTCCTTTGTTTTGGATTACATAAACCAGTCACCCAAGTGCATTGCCTTTGGA AACGAGGGAGTATATGTTGCTGCAGTACGGGAATTTTACTTGTCTGTTTATTTTTTCAAAAAGAAAACAACATCAAGGTTTACTTTATCA TCATCAAGAAATAAGAAGCATGCTAAAAACAATTTTACATGTGTAGCATGTCACCCAACGGAAGACTGCATCGCATCTGGTCACATGGAT GGCAAAATTCGTCTTTGGAGGAATTTTTATGATGATAAGAAATATACGTACACATGTTTACATTGGCACCATGATATGGTTATGGATTTG GCTTTTTCAGTGACAGGCACCAGTCTGCTGAGTGGCGGTCGTGAATCTGTACTTGTAGAGTGGCGCGATGCAACAGAGAAGAATAAGGAG TTTCTCCCGCGTTTAGGAGCTACTATTGAACATATCTCAGTCTCGCCTGCAGGAGATTTATTCTGCACTTCTCACTCTGATAATAAGATA ATAATTATTCACCGAAACCTTGAAGCATCCGCAGTAATTCAAGGCCTAGTGAAAGATAGGAGTATCTTCACTGGTTTGATGATTGATCCA AGAACTAAAGCTTTGGTTTTGAATGGAAAACCTGGCCACCTGCAGTTTTATTCTCTCCAGAGTGATAAACAGTTATACAATTTAGATATT ATACAGCAAGAATATATTAATGATTATGGTCTGATCCAAATTGAACTAACAAAGGCTGCATTTGGCTGCTTTGGTAACTGGCTTGCAACA GTGGAACAGCGGCAAGAAAAGGAAACTGAGCTTGAATTGCAAATGAAACTGTGGATGTATAATAAGAAAACACAAGGGTTTATTCTTAAC ACTAAAATTAACATGCCACACGAAGACTGCATTACAGCTCTCTGTTTCTGTAATGCAGAAAAATCTGAACAGCCCACCTTGGTTACAGCT AGCAAAGATGGTTACTTCAAAGTATGGATATTAACAGATGACTCTGACATATACAAAAAAGCTGTTGGCTGGACCTGTGACTTTGTTGGT AGTTATCACAAGTATCAAGCAACTAACTGTTGTTTCTCCGAAGATGGTTCTTTACTAGCAGTTAGTTTTGAGGAAATAGTCACAATATGG GATTCTGTAACATGGGAACTTAAATGTACATTTTGCCAACGAGCTGGGAAAATAAGGCACCTTTGCTTTGGGAGATTGACGTGTTCAAAG TATCTACTTGGTGCTACTGAAAATGGCATTCTTTGCTGTTGGAATCTGCTGAGCTGTGCATTGGAGTGGAATGCAAAATTAAATGTTAGA GTTATGGAACCCGATCCTAATTCAGAGAATATTGCTGCAATCTCTCAGTCTTCAGTGGGTTCAGACTTGTTTGTATTTAAACCTAGTGAG CCAAGGCCATTGTATATTCAAAAGGGTATCTCCAGAGAGAAAGTCCAGTGGGGAGTGTTTGTTCCACGAGATGTCCCTGAATCCTTCACC TCAGAAGCTTACCAGTGGCTAAATAGATCCCAGTTTTACTTCCTAACAAAATCACAGAGTTTATTGACATTCAGTACAAAGTCTCCAGAA GAAAAACTCACACCAACAAGCAAACAGCTGCTAGCAGAAGAAAGTCTTCCCACAACCCCATTTTATTTCATATTGGGAAAACACAGGCAA CAGCAGGATGAAAAACTAAACGAAACTTTAGAGAATGAGCTGGTACAACTACCCTTAACAGAAAACATACCCGCAATTAGTGAGCTTCTT CACACTCCAGCCCATGTCCTGCCATCTGCTGCTTTCCTGTGCTCCATGTTTGTAAATTCATTGCTGCTGTCTAAAGAGACTAAGAGTGCT AAGGAAATTCCTGAAGATGTAGATATGGAAGAAGAAAAAGAAAGTGAAGATTCAGATGAAGAAAATGATTTTACCGAAAAAGTCCAGGAT ACAAGTAACACAGGTTTAGGAGAAGACATTATACATCAGTTGTCAAAATCTGAAGAAAAAGAACTGAGAAAATTTAGGAAAATAGACTAC AGCTGGATAGCTGCCCTTTAAGCCTTGGAGATGGGGAGGATCCTTGGACTTTGTGTTTTTGATTGTATGTTGATATTCTAAAAACATCTA >22925_22925_5_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000409307_WDR75_chr2_190313104_ENST00000314761_length(amino acids)=1176AA_BP=374 MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP WTIPPEEFSKRRDLRYIFCVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFIVGCKLHA LFTLAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSVYFFKKKTTSRFTLS SSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKE FLPRLGATIEHISVSPAGDLFCTSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQSDKQLYNLDI IQQEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMKLWMYNKKTQGFILNTKINMPHEDCITALCFCNAEKSEQPTLVTA SKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAGKIRHLCFGRLTCSK YLLGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQSSVGSDLFVFKPSEPRPLYIQKGISREKVQWGVFVPRDVPESFT SEAYQWLNRSQFYFLTKSQSLLTFSTKSPEEKLTPTSKQLLAEESLPTTPFYFILGKHRQQQDEKLNETLENELVQLPLTENIPAISELL HTPAHVLPSAAFLCSMFVNSLLLSKETKSAKEIPEDVDMEEEKESEDSDEENDFTEKVQDTSNTGLGEDIIHQLSKSEEKELRKFRKIDY -------------------------------------------------------------- >22925_22925_6_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000409307_WDR75_chr2_190313105_ENST00000314761_length(transcript)=3679nt_BP=1124nt ATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCT TCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCA GAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGT GATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCAT TGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTC CCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGC ATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACA AAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAG AAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCC TCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTG TTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAG CCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCA TGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGGTATATCTTCTGTGTCTCTGGAGACTTTGTTAAAGTTTACAGCACA GTTACAGAAGAGTGTGTACACATACTGCATGGACACAGAAATCTGGTGACTGGAATCCAGCTTAACCCCAACAACCATCTACAGCTGTAT TCTTGTTCCCTTGATGGCACAATTAAACTGTGGGACTATATAGATGGCATCTTAATAAAGACTTTCATAGTTGGATGTAAACTTCATGCC CTCTTTACTCTTGCCCAAGCTGAGGATTCTGTCTTTGTTATAGTGAATAAAGAAAAACCAGATATATTTCAGCTGGTTTCAGTGAAACTG CCAAAATCCTCAAGCCAGGAAGTAGAAGCCAAGGAGCTGTCCTTTGTTTTGGATTACATAAACCAGTCACCCAAGTGCATTGCCTTTGGA AACGAGGGAGTATATGTTGCTGCAGTACGGGAATTTTACTTGTCTGTTTATTTTTTCAAAAAGAAAACAACATCAAGGTTTACTTTATCA TCATCAAGAAATAAGAAGCATGCTAAAAACAATTTTACATGTGTAGCATGTCACCCAACGGAAGACTGCATCGCATCTGGTCACATGGAT GGCAAAATTCGTCTTTGGAGGAATTTTTATGATGATAAGAAATATACGTACACATGTTTACATTGGCACCATGATATGGTTATGGATTTG GCTTTTTCAGTGACAGGCACCAGTCTGCTGAGTGGCGGTCGTGAATCTGTACTTGTAGAGTGGCGCGATGCAACAGAGAAGAATAAGGAG TTTCTCCCGCGTTTAGGAGCTACTATTGAACATATCTCAGTCTCGCCTGCAGGAGATTTATTCTGCACTTCTCACTCTGATAATAAGATA ATAATTATTCACCGAAACCTTGAAGCATCCGCAGTAATTCAAGGCCTAGTGAAAGATAGGAGTATCTTCACTGGTTTGATGATTGATCCA AGAACTAAAGCTTTGGTTTTGAATGGAAAACCTGGCCACCTGCAGTTTTATTCTCTCCAGAGTGATAAACAGTTATACAATTTAGATATT ATACAGCAAGAATATATTAATGATTATGGTCTGATCCAAATTGAACTAACAAAGGCTGCATTTGGCTGCTTTGGTAACTGGCTTGCAACA GTGGAACAGCGGCAAGAAAAGGAAACTGAGCTTGAATTGCAAATGAAACTGTGGATGTATAATAAGAAAACACAAGGGTTTATTCTTAAC ACTAAAATTAACATGCCACACGAAGACTGCATTACAGCTCTCTGTTTCTGTAATGCAGAAAAATCTGAACAGCCCACCTTGGTTACAGCT AGCAAAGATGGTTACTTCAAAGTATGGATATTAACAGATGACTCTGACATATACAAAAAAGCTGTTGGCTGGACCTGTGACTTTGTTGGT AGTTATCACAAGTATCAAGCAACTAACTGTTGTTTCTCCGAAGATGGTTCTTTACTAGCAGTTAGTTTTGAGGAAATAGTCACAATATGG GATTCTGTAACATGGGAACTTAAATGTACATTTTGCCAACGAGCTGGGAAAATAAGGCACCTTTGCTTTGGGAGATTGACGTGTTCAAAG TATCTACTTGGTGCTACTGAAAATGGCATTCTTTGCTGTTGGAATCTGCTGAGCTGTGCATTGGAGTGGAATGCAAAATTAAATGTTAGA GTTATGGAACCCGATCCTAATTCAGAGAATATTGCTGCAATCTCTCAGTCTTCAGTGGGTTCAGACTTGTTTGTATTTAAACCTAGTGAG CCAAGGCCATTGTATATTCAAAAGGGTATCTCCAGAGAGAAAGTCCAGTGGGGAGTGTTTGTTCCACGAGATGTCCCTGAATCCTTCACC TCAGAAGCTTACCAGTGGCTAAATAGATCCCAGTTTTACTTCCTAACAAAATCACAGAGTTTATTGACATTCAGTACAAAGTCTCCAGAA GAAAAACTCACACCAACAAGCAAACAGCTGCTAGCAGAAGAAAGTCTTCCCACAACCCCATTTTATTTCATATTGGGAAAACACAGGCAA CAGCAGGATGAAAAACTAAACGAAACTTTAGAGAATGAGCTGGTACAACTACCCTTAACAGAAAACATACCCGCAATTAGTGAGCTTCTT CACACTCCAGCCCATGTCCTGCCATCTGCTGCTTTCCTGTGCTCCATGTTTGTAAATTCATTGCTGCTGTCTAAAGAGACTAAGAGTGCT AAGGAAATTCCTGAAGATGTAGATATGGAAGAAGAAAAAGAAAGTGAAGATTCAGATGAAGAAAATGATTTTACCGAAAAAGTCCAGGAT ACAAGTAACACAGGTTTAGGAGAAGACATTATACATCAGTTGTCAAAATCTGAAGAAAAAGAACTGAGAAAATTTAGGAAAATAGACTAC AGCTGGATAGCTGCCCTTTAAGCCTTGGAGATGGGGAGGATCCTTGGACTTTGTGTTTTTGATTGTATGTTGATATTCTAAAAACATCTA >22925_22925_6_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000409307_WDR75_chr2_190313105_ENST00000314761_length(amino acids)=1176AA_BP=374 MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP WTIPPEEFSKRRDLRYIFCVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFIVGCKLHA LFTLAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSVYFFKKKTTSRFTLS SSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKE FLPRLGATIEHISVSPAGDLFCTSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQSDKQLYNLDI IQQEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMKLWMYNKKTQGFILNTKINMPHEDCITALCFCNAEKSEQPTLVTA SKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAGKIRHLCFGRLTCSK YLLGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQSSVGSDLFVFKPSEPRPLYIQKGISREKVQWGVFVPRDVPESFT SEAYQWLNRSQFYFLTKSQSLLTFSTKSPEEKLTPTSKQLLAEESLPTTPFYFILGKHRQQQDEKLNETLENELVQLPLTENIPAISELL HTPAHVLPSAAFLCSMFVNSLLLSKETKSAKEIPEDVDMEEEKESEDSDEENDFTEKVQDTSNTGLGEDIIHQLSKSEEKELRKFRKIDY -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for DIS3L2-WDR75 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DIS3L2-WDR75 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DIS3L2-WDR75 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DIS3L2 | C0796113 | Nephroblastomatosis, fetal ascites, macrosomia and Wilms tumor | 6 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |