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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLEKHH2-THADA (FusionGDB2 ID:HG130271TG63892)

Fusion Gene Summary for PLEKHH2-THADA

check button Fusion gene summary
Fusion gene informationFusion gene name: PLEKHH2-THADA
Fusion gene ID: hg130271tg63892
HgeneTgene
Gene symbol

PLEKHH2

THADA

Gene ID

130271

63892

Gene namepleckstrin homology, MyTH4 and FERM domain containing H2THADA armadillo repeat containing
SynonymsPLEKHH1LARMC13|GITA
Cytomap('PLEKHH2')('THADA')

2p21

2p21

Type of geneprotein-codingprotein-coding
Descriptionpleckstrin homology domain-containing family H member 2pleckstrin homology domain containing, family H (with MyTH4 domain) member 2thyroid adenoma-associated proteindeath receptor-interacting proteingene inducing thyroid adenomas protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000282406, 
Fusion gene scores* DoF score4 X 3 X 4=4819 X 13 X 11=2717
# samples 520
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(20/2717*10)=-3.76394266044725
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLEKHH2 [Title/Abstract] AND THADA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLEKHH2(43871935)-THADA(43755127), # samples:1
Anticipated loss of major functional domain due to fusion event.PLEKHH2-THADA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PLEKHH2-THADA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PLEKHH2-THADA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PLEKHH2-THADA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PLEKHH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across THADA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-DS-A1O9-01APLEKHH2chr2

43871935

+THADAchr2

43755127

-


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Fusion Gene ORF analysis for PLEKHH2-THADA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000282406ENST00000402360PLEKHH2chr2

43871935

+THADAchr2

43755127

-
5CDS-intronENST00000282406ENST00000403856PLEKHH2chr2

43871935

+THADAchr2

43755127

-
5CDS-intronENST00000282406ENST00000404790PLEKHH2chr2

43871935

+THADAchr2

43755127

-
5CDS-intronENST00000282406ENST00000485353PLEKHH2chr2

43871935

+THADAchr2

43755127

-
In-frameENST00000282406ENST00000330266PLEKHH2chr2

43871935

+THADAchr2

43755127

-
In-frameENST00000282406ENST00000405006PLEKHH2chr2

43871935

+THADAchr2

43755127

-
In-frameENST00000282406ENST00000405975PLEKHH2chr2

43871935

+THADAchr2

43755127

-
In-frameENST00000282406ENST00000415080PLEKHH2chr2

43871935

+THADAchr2

43755127

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000282406PLEKHH2chr243871935+ENST00000330266THADAchr243755127-11332331101132341
ENST00000282406PLEKHH2chr243871935+ENST00000405975THADAchr243755127-29432331102830906
ENST00000282406PLEKHH2chr243871935+ENST00000415080THADAchr243755127-28552331102743877
ENST00000282406PLEKHH2chr243871935+ENST00000405006THADAchr243755127-29272331102830906

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000282406ENST00000330266PLEKHH2chr243871935+THADAchr243755127-0.0029309750.99706906
ENST00000282406ENST00000405975PLEKHH2chr243871935+THADAchr243755127-0.0007932420.99920684
ENST00000282406ENST00000415080PLEKHH2chr243871935+THADAchr243755127-0.0009474280.9990526
ENST00000282406ENST00000405006PLEKHH2chr243871935+THADAchr243755127-0.0007773810.99922264

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Fusion Genomic Features for PLEKHH2-THADA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for PLEKHH2-THADA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:43871935/chr2:43755127)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTHADAchr2:43871935chr2:43755127ENST00000402360017886_9180938.0Coiled coilOntology_term=ECO:0000255
TgeneTHADAchr2:43871935chr2:43755127ENST000004023600171322_13270938.0Compositional biasNote=Poly-Leu
TgeneTHADAchr2:43871935chr2:43755127ENST000004023600171529_15320938.0Compositional biasNote=Poly-Ala
TgeneTHADAchr2:43871935chr2:43755127ENST000004023600174_70938.0Compositional biasNote=Poly-Lys
TgeneTHADAchr2:43871935chr2:43755127ENST0000040500620381322_132710881954.0Compositional biasNote=Poly-Leu
TgeneTHADAchr2:43871935chr2:43755127ENST0000040500620381529_153210881954.0Compositional biasNote=Poly-Ala
TgeneTHADAchr2:43871935chr2:43755127ENST0000040597520381322_132710881954.0Compositional biasNote=Poly-Leu
TgeneTHADAchr2:43871935chr2:43755127ENST0000040597520381529_153210881954.0Compositional biasNote=Poly-Ala

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHH2chr2:43871935chr2:43755127ENST00000282406+23020_175411494.0Coiled coilOntology_term=ECO:0000255
HgenePLEKHH2chr2:43871935chr2:43755127ENST00000282406+230398_402411494.0Compositional biasNote=Poly-Ser
HgenePLEKHH2chr2:43871935chr2:43755127ENST00000282406+230613_666411494.0Compositional biasNote=Ser-rich
HgenePLEKHH2chr2:43871935chr2:43755127ENST00000282406+230693_696411494.0Compositional biasNote=Poly-Ser
HgenePLEKHH2chr2:43871935chr2:43755127ENST00000282406+2301121_1451411494.0DomainFERM
HgenePLEKHH2chr2:43871935chr2:43755127ENST00000282406+230703_797411494.0DomainPH 1
HgenePLEKHH2chr2:43871935chr2:43755127ENST00000282406+230811_919411494.0DomainPH 2
HgenePLEKHH2chr2:43871935chr2:43755127ENST00000282406+230955_1110411494.0DomainMyTH4
TgeneTHADAchr2:43871935chr2:43755127ENST000004050062038886_91810881954.0Coiled coilOntology_term=ECO:0000255
TgeneTHADAchr2:43871935chr2:43755127ENST000004059752038886_91810881954.0Coiled coilOntology_term=ECO:0000255
TgeneTHADAchr2:43871935chr2:43755127ENST0000040500620384_710881954.0Compositional biasNote=Poly-Lys
TgeneTHADAchr2:43871935chr2:43755127ENST0000040597520384_710881954.0Compositional biasNote=Poly-Lys


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Fusion Gene Sequence for PLEKHH2-THADA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66296_66296_1_PLEKHH2-THADA_PLEKHH2_chr2_43871935_ENST00000282406_THADA_chr2_43755127_ENST00000330266_length(transcript)=1133nt_BP=233nt
GAGCTCGGCTTGAGGCGGGCGCGGGCTGAGAGTCCGGGGATCCCGGGGGCCAGTCGCGGCCGGGACATCGGGCGCTGCGGCCGGGGACCC
GCTGCTGAGATAGACAGAATATGGCAGAGCTTTCTGAGCCAGAGGGACCAGTAGATTGGAAGGAACGATGTGTAGCTCTGGAGTCCCAAC
TCATGAAATTTAGAGTTCAAGCAAGCAAGATACGAGAGCTTTTAGCAGAGAAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTTT
TGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGTC
TGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGCA
GTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAGT
TAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGATA
CGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCAGTGCGAA
ATTCATCCACACTTCTCTTTAGTGCCTTGATCACAAGAATTTTTGGAGTTAAAAGGGCAAAGGATGAACATTCCAAAACAAATAGAATGA
CAGGGAGAGAGTTTTTCTCTCGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAGCCAATACAGTAGACAGTGATA
TGGGAGAACCAAATCGTCATCCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCCCGATGGATGGTACTTCTTCTG
CTCTCAGCATGGGACCTTTTGTTCCCTTCATTATGAGAGTCTTGCTCTGTTGTCCAGGCTGGAGTGCAGTGGCACGATCTCAGCTCACTG

>66296_66296_1_PLEKHH2-THADA_PLEKHH2_chr2_43871935_ENST00000282406_THADA_chr2_43755127_ENST00000330266_length(amino acids)=341AA_BP=40
MAELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQ
WLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKELISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENI
IPYVADGAKAAILGFTSPVWAVRNSSTLLFSALITRIFGVKRAKDEHSKTNRMTGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRH

--------------------------------------------------------------
>66296_66296_2_PLEKHH2-THADA_PLEKHH2_chr2_43871935_ENST00000282406_THADA_chr2_43755127_ENST00000405006_length(transcript)=2927nt_BP=233nt
GAGCTCGGCTTGAGGCGGGCGCGGGCTGAGAGTCCGGGGATCCCGGGGGCCAGTCGCGGCCGGGACATCGGGCGCTGCGGCCGGGGACCC
GCTGCTGAGATAGACAGAATATGGCAGAGCTTTCTGAGCCAGAGGGACCAGTAGATTGGAAGGAACGATGTGTAGCTCTGGAGTCCCAAC
TCATGAAATTTAGAGTTCAAGCAAGCAAGATACGAGAGCTTTTAGCAGAGAAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTTT
TGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGTC
TGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGCA
GTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAGT
TAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGATA
CGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCAGTGCGAA
ATTCATCCACACTTCTCTTTAGTGCCTTGATCACAAGAATTTTTGGAGTTAAAAGGGCAAAGGATGAACATTCCAAAACAAATAGAATGA
CAGGGAGAGAGTTTTTCTCTCGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAGCCAATACAGTAGACAGTGATA
TGGGAGAACCAAATCGTCATCCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCCCGATGGATGGTACTTCTTCTG
CTCTCAGCATGGGACCTTTTGTTCCCTTCATTATGAGGTGTGGTCACTCACCTGTCTACCACTCCCGTGAAATGGCAGCTCGTGCCTTGG
TCCCATTTGTTATGATAGATCACATTCCTAATACCATTCGAACTCTGTTGTCCACACTCCCCAGCTGCACTGACCAGTGTTTCCGGCAAA
ACCACATTCATGGGACACTTCTCCAGGTTTTTCATTTGTTGCAAGCCTACTCAGACTCCAAACACGGAACGAATTCAGACTTCCAGCACG
AGCTGACTGACATCACTGTTTGTACCAAAGCCAAACTCTGGCTGGCCAAGAGGCAAAATCCATGTTTGGTGACCAGAGCTGTATATATTG
ATATTCTCTTCCTATTGACTTGCTGCCTCAACAGATCTGCAAAGGACAACCAGCCAGTTCTGGAGAGTCTTGGCTTCTGGGAGGAAGTCA
GAGGGATTATCTCAGGATCAGAGCTGATAACGGGATTCCCTTGGGCCTTCAAGGTGCCAGGCCTGCCCCAGTACCTCCAGAGCCTCACCA
GACTAGCCATTGCTGCAGTGTGGGCCGCGGCAGCCAAGAGTGGAGAGCGGGAGACGAATGTCCCCATCTCTTTCTCTCAGCTGTTAGAAT
CTGCCTTCCCTGAAGTGCGCTCACTAACACTGGAAGCCCTCTTGGAAAAGTTCTTAGCAGCAGCCTCTGGACTTGGAGAGAAGGGCGTGC
CACCCTTGCTGTGCAACATGGGAGAGAAGTTCTTATTGTTGGCCATGAAGGAAAATCACCCAGAATGCTTCTGCAAGATACTGAAAATTC
TCCACTGCATGGACCCTGGTGAGTGGCTTCCCCAGACGGAGCACTGTGTCCATCTGACCCCAAAGGAGTTCTTGATCTGGACGATGGATA
TTGCTTCCAATGAAAGATCTGAAATTCAGAGTGTAGCTCTGAGACTTGCTTCCAAAGTCATTTCCCACCACATGCAGACATGTGTGGAGA
ACAGGGAATTGATAGCTGCTGAGCTGAAGCAGTGGGTTCAGCTGGTCATCTTGTCATGTGAAGACCATCTTCCTACAGAGTCTAGGCTGG
CCGTCGTTGAAGTCCTCACCAGTACTACACCACTTTTCCTCACCAACCCCCATCCTATTCTTGAGTTGCAGGATACACTTGCTCTCTGGA
AGTGTGTCCTTACCCTTCTGCAGAGTGAGGAGCAAGCTGTTAGAGATGCAGCCACGGAAACCGTGACAACTGCCATGTCACAAGAAAATA
CCTGCCAGTCAACAGAGTTTGCCTTCTGCCAGGTGGATGCCTCCATCGCTCTGGCCCTGGCCCTGGCCGTCCTGTGTGATCTGCTCCAGC
AGTGGGACCAGTTGGCCCCTGGACTGCCCATCCTGCTGGGATGGCTGTTGGGAGAGAGTGATGACCTCGTGGCCTGTGTGGAGAGCATGC
ATCAGGTGGAAGAAGACTACCTGTTTGAAAAAGCAGAAGTCAACTTTTGGGCCGAGACCCTGATCTTTGTGAAATACCTCTGCAAGCACC
TCTTCTGTCTCCTCTCAAAGTCCGGCTGGCGTCCCCCAAGCCCTGAGATGCTCTGTCACCTTCAAAGGATGGTGTCAGAGCAGTGCCACC
TCCTGTCTCAGTTCTTCAGAGAGCTTCCACCAGCTGCTGAGTTTGTGAAGACAGTGGAGTTCACAAGACTACGCATTCAAGAGGAAAGGA
CTTTGGCTTGCTTGAGGCTGCTGGCCTTTTTGGAAGGAAAGGAAGGGGAAGACACCCTAGTTCTCAGTGTTTGGGACTCTTATGCAGAAT
CGAGGCAGTTAACTCTTCCAAGAACAGAAGCGGCATGTTGAAGAAAATCTGGGGGATTGGGATGGGGGTATGTGTGGATTTTTCCTCCAC

>66296_66296_2_PLEKHH2-THADA_PLEKHH2_chr2_43871935_ENST00000282406_THADA_chr2_43755127_ENST00000405006_length(amino acids)=906AA_BP=40
MAELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQ
WLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKELISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENI
IPYVADGAKAAILGFTSPVWAVRNSSTLLFSALITRIFGVKRAKDEHSKTNRMTGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRH
PSMFLLLLVLERLYASPMDGTSSALSMGPFVPFIMRCGHSPVYHSREMAARALVPFVMIDHIPNTIRTLLSTLPSCTDQCFRQNHIHGTL
LQVFHLLQAYSDSKHGTNSDFQHELTDITVCTKAKLWLAKRQNPCLVTRAVYIDILFLLTCCLNRSAKDNQPVLESLGFWEEVRGIISGS
ELITGFPWAFKVPGLPQYLQSLTRLAIAAVWAAAAKSGERETNVPISFSQLLESAFPEVRSLTLEALLEKFLAAASGLGEKGVPPLLCNM
GEKFLLLAMKENHPECFCKILKILHCMDPGEWLPQTEHCVHLTPKEFLIWTMDIASNERSEIQSVALRLASKVISHHMQTCVENRELIAA
ELKQWVQLVILSCEDHLPTESRLAVVEVLTSTTPLFLTNPHPILELQDTLALWKCVLTLLQSEEQAVRDAATETVTTAMSQENTCQSTEF
AFCQVDASIALALALAVLCDLLQQWDQLAPGLPILLGWLLGESDDLVACVESMHQVEEDYLFEKAEVNFWAETLIFVKYLCKHLFCLLSK
SGWRPPSPEMLCHLQRMVSEQCHLLSQFFRELPPAAEFVKTVEFTRLRIQEERTLACLRLLAFLEGKEGEDTLVLSVWDSYAESRQLTLP

--------------------------------------------------------------
>66296_66296_3_PLEKHH2-THADA_PLEKHH2_chr2_43871935_ENST00000282406_THADA_chr2_43755127_ENST00000405975_length(transcript)=2943nt_BP=233nt
GAGCTCGGCTTGAGGCGGGCGCGGGCTGAGAGTCCGGGGATCCCGGGGGCCAGTCGCGGCCGGGACATCGGGCGCTGCGGCCGGGGACCC
GCTGCTGAGATAGACAGAATATGGCAGAGCTTTCTGAGCCAGAGGGACCAGTAGATTGGAAGGAACGATGTGTAGCTCTGGAGTCCCAAC
TCATGAAATTTAGAGTTCAAGCAAGCAAGATACGAGAGCTTTTAGCAGAGAAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTTT
TGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGTC
TGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGCA
GTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAGT
TAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGATA
CGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCAGTGCGAA
ATTCATCCACACTTCTCTTTAGTGCCTTGATCACAAGAATTTTTGGAGTTAAAAGGGCAAAGGATGAACATTCCAAAACAAATAGAATGA
CAGGGAGAGAGTTTTTCTCTCGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAGCCAATACAGTAGACAGTGATA
TGGGAGAACCAAATCGTCATCCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCCCGATGGATGGTACTTCTTCTG
CTCTCAGCATGGGACCTTTTGTTCCCTTCATTATGAGGTGTGGTCACTCACCTGTCTACCACTCCCGTGAAATGGCAGCTCGTGCCTTGG
TCCCATTTGTTATGATAGATCACATTCCTAATACCATTCGAACTCTGTTGTCCACACTCCCCAGCTGCACTGACCAGTGTTTCCGGCAAA
ACCACATTCATGGGACACTTCTCCAGGTTTTTCATTTGTTGCAAGCCTACTCAGACTCCAAACACGGAACGAATTCAGACTTCCAGCACG
AGCTGACTGACATCACTGTTTGTACCAAAGCCAAACTCTGGCTGGCCAAGAGGCAAAATCCATGTTTGGTGACCAGAGCTGTATATATTG
ATATTCTCTTCCTATTGACTTGCTGCCTCAACAGATCTGCAAAGGACAACCAGCCAGTTCTGGAGAGTCTTGGCTTCTGGGAGGAAGTCA
GAGGGATTATCTCAGGATCAGAGCTGATAACGGGATTCCCTTGGGCCTTCAAGGTGCCAGGCCTGCCCCAGTACCTCCAGAGCCTCACCA
GACTAGCCATTGCTGCAGTGTGGGCCGCGGCAGCCAAGAGTGGAGAGCGGGAGACGAATGTCCCCATCTCTTTCTCTCAGCTGTTAGAAT
CTGCCTTCCCTGAAGTGCGCTCACTAACACTGGAAGCCCTCTTGGAAAAGTTCTTAGCAGCAGCCTCTGGACTTGGAGAGAAGGGCGTGC
CACCCTTGCTGTGCAACATGGGAGAGAAGTTCTTATTGTTGGCCATGAAGGAAAATCACCCAGAATGCTTCTGCAAGATACTGAAAATTC
TCCACTGCATGGACCCTGGTGAGTGGCTTCCCCAGACGGAGCACTGTGTCCATCTGACCCCAAAGGAGTTCTTGATCTGGACGATGGATA
TTGCTTCCAATGAAAGATCTGAAATTCAGAGTGTAGCTCTGAGACTTGCTTCCAAAGTCATTTCCCACCACATGCAGACATGTGTGGAGA
ACAGGGAATTGATAGCTGCTGAGCTGAAGCAGTGGGTTCAGCTGGTCATCTTGTCATGTGAAGACCATCTTCCTACAGAGTCTAGGCTGG
CCGTCGTTGAAGTCCTCACCAGTACTACACCACTTTTCCTCACCAACCCCCATCCTATTCTTGAGTTGCAGGATACACTTGCTCTCTGGA
AGTGTGTCCTTACCCTTCTGCAGAGTGAGGAGCAAGCTGTTAGAGATGCAGCCACGGAAACCGTGACAACTGCCATGTCACAAGAAAATA
CCTGCCAGTCAACAGAGTTTGCCTTCTGCCAGGTGGATGCCTCCATCGCTCTGGCCCTGGCCCTGGCCGTCCTGTGTGATCTGCTCCAGC
AGTGGGACCAGTTGGCCCCTGGACTGCCCATCCTGCTGGGATGGCTGTTGGGAGAGAGTGATGACCTCGTGGCCTGTGTGGAGAGCATGC
ATCAGGTGGAAGAAGACTACCTGTTTGAAAAAGCAGAAGTCAACTTTTGGGCCGAGACCCTGATCTTTGTGAAATACCTCTGCAAGCACC
TCTTCTGTCTCCTCTCAAAGTCCGGCTGGCGTCCCCCAAGCCCTGAGATGCTCTGTCACCTTCAAAGGATGGTGTCAGAGCAGTGCCACC
TCCTGTCTCAGTTCTTCAGAGAGCTTCCACCAGCTGCTGAGTTTGTGAAGACAGTGGAGTTCACAAGACTACGCATTCAAGAGGAAAGGA
CTTTGGCTTGCTTGAGGCTGCTGGCCTTTTTGGAAGGAAAGGAAGGGGAAGACACCCTAGTTCTCAGTGTTTGGGACTCTTATGCAGAAT
CGAGGCAGTTAACTCTTCCAAGAACAGAAGCGGCATGTTGAAGAAAATCTGGGGGATTGGGATGGGGGTATGTGTGGATTTTTCCTCCAC

>66296_66296_3_PLEKHH2-THADA_PLEKHH2_chr2_43871935_ENST00000282406_THADA_chr2_43755127_ENST00000405975_length(amino acids)=906AA_BP=40
MAELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQ
WLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKELISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENI
IPYVADGAKAAILGFTSPVWAVRNSSTLLFSALITRIFGVKRAKDEHSKTNRMTGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRH
PSMFLLLLVLERLYASPMDGTSSALSMGPFVPFIMRCGHSPVYHSREMAARALVPFVMIDHIPNTIRTLLSTLPSCTDQCFRQNHIHGTL
LQVFHLLQAYSDSKHGTNSDFQHELTDITVCTKAKLWLAKRQNPCLVTRAVYIDILFLLTCCLNRSAKDNQPVLESLGFWEEVRGIISGS
ELITGFPWAFKVPGLPQYLQSLTRLAIAAVWAAAAKSGERETNVPISFSQLLESAFPEVRSLTLEALLEKFLAAASGLGEKGVPPLLCNM
GEKFLLLAMKENHPECFCKILKILHCMDPGEWLPQTEHCVHLTPKEFLIWTMDIASNERSEIQSVALRLASKVISHHMQTCVENRELIAA
ELKQWVQLVILSCEDHLPTESRLAVVEVLTSTTPLFLTNPHPILELQDTLALWKCVLTLLQSEEQAVRDAATETVTTAMSQENTCQSTEF
AFCQVDASIALALALAVLCDLLQQWDQLAPGLPILLGWLLGESDDLVACVESMHQVEEDYLFEKAEVNFWAETLIFVKYLCKHLFCLLSK
SGWRPPSPEMLCHLQRMVSEQCHLLSQFFRELPPAAEFVKTVEFTRLRIQEERTLACLRLLAFLEGKEGEDTLVLSVWDSYAESRQLTLP

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>66296_66296_4_PLEKHH2-THADA_PLEKHH2_chr2_43871935_ENST00000282406_THADA_chr2_43755127_ENST00000415080_length(transcript)=2855nt_BP=233nt
GAGCTCGGCTTGAGGCGGGCGCGGGCTGAGAGTCCGGGGATCCCGGGGGCCAGTCGCGGCCGGGACATCGGGCGCTGCGGCCGGGGACCC
GCTGCTGAGATAGACAGAATATGGCAGAGCTTTCTGAGCCAGAGGGACCAGTAGATTGGAAGGAACGATGTGTAGCTCTGGAGTCCCAAC
TCATGAAATTTAGAGTTCAAGCAAGCAAGATACGAGAGCTTTTAGCAGAGAAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTTT
TGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGTC
TGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGCA
GTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAGT
TAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGATA
CGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCATCTCAAA
TGACAGGGAGAGAGTTTTTCTCTCGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAGCCAATACAGTAGACAGTG
ATATGGGAGAACCAAATCGTCATCCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCCCGATGGATGGTACTTCTT
CTGCTCTCAGCATGGGACCTTTTGTTCCCTTCATTATGAGGTGTGGTCACTCACCTGTCTACCACTCCCGTGAAATGGCAGCTCGTGCCT
TGGTCCCATTTGTTATGATAGATCACATTCCTAATACCATTCGAACTCTGTTGTCCACACTCCCCAGCTGCACTGACCAGTGTTTCCGGC
AAAACCACATTCATGGGACACTTCTCCAGGTTTTTCATTTGTTGCAAGCCTACTCAGACTCCAAACACGGAACGAATTCAGACTTCCAGC
ACGAGCTGACTGACATCACTGTTTGTACCAAAGCCAAACTCTGGCTGGCCAAGAGGCAAAATCCATGTTTGGTGACCAGAGCTGTATATA
TTGATATTCTCTTCCTATTGACTTGCTGCCTCAACAGATCTGCAAAGGACAACCAGCCAGTTCTGGAGAGTCTTGGCTTCTGGGAGGAAG
TCAGAGGGATTATCTCAGGATCAGAGCTGATAACGGGATTCCCTTGGGCCTTCAAGGTGCCAGGCCTGCCCCAGTACCTCCAGAGCCTCA
CCAGACTAGCCATTGCTGCAGTGTGGGCCGCGGCAGCCAAGAGTGGAGAGCGGGAGACGAATGTCCCCATCTCTTTCTCTCAGCTGTTAG
AATCTGCCTTCCCTGAAGTGCGCTCACTAACACTGGAAGCCCTCTTGGAAAAGTTCTTAGCAGCAGCCTCTGGACTTGGAGAGAAGGGCG
TGCCACCCTTGCTGTGCAACATGGGAGAGAAGTTCTTATTGTTGGCCATGAAGGAAAATCACCCAGAATGCTTCTGCAAGATACTGAAAA
TTCTCCACTGCATGGACCCTGGTGAGTGGCTTCCCCAGACGGAGCACTGTGTCCATCTGACCCCAAAGGAGTTCTTGATCTGGACGATGG
ATATTGCTTCCAATGAAAGATCTGAAATTCAGAGTGTAGCTCTGAGACTTGCTTCCAAAGTCATTTCCCACCACATGCAGACATGTGTGG
AGAACAGGGAATTGATAGCTGCTGAGCTGAAGCAGTGGGTTCAGCTGGTCATCTTGTCATGTGAAGACCATCTTCCTACAGAGTCTAGGC
TGGCCGTCGTTGAAGTCCTCACCAGTACTACACCACTTTTCCTCACCAACCCCCATCCTATTCTTGAGTTGCAGGATACACTTGCTCTCT
GGAAGTGTGTCCTTACCCTTCTGCAGAGTGAGGAGCAAGCTGTTAGAGATGCAGCCACGGAAACCGTGACAACTGCCATGTCACAAGAAA
ATACCTGCCAGTCAACAGAGTTTGCCTTCTGCCAGGTGGATGCCTCCATCGCTCTGGCCCTGGCCCTGGCCGTCCTGTGTGATCTGCTCC
AGCAGTGGGACCAGTTGGCCCCTGGACTGCCCATCCTGCTGGGATGGCTGTTGGGAGAGAGTGATGACCTCGTGGCCTGTGTGGAGAGCA
TGCATCAGGTGGAAGAAGACTACCTGTTTGAAAAAGCAGAAGTCAACTTTTGGGCCGAGACCCTGATCTTTGTGAAATACCTCTGCAAGC
ACCTCTTCTGTCTCCTCTCAAAGTCCGGCTGGCGTCCCCCAAGCCCTGAGATGCTCTGTCACCTTCAAAGGATGGTGTCAGAGCAGTGCC
ACCTCCTGTCTCAGTTCTTCAGAGAGCTTCCACCAGCTGCTGAGTTTGTGAAGACAGTGGAGTTCACAAGACTACGCATTCAAGAGGAAA
GGACTTTGGCTTGCTTGAGGCTGCTGGCCTTTTTGGAAGGAAAGGAAGGGGAAGACACCCTAGTTCTCAGTGTTTGGGACTCTTATGCAG
AATCGAGGCAGTTAACTCTTCCAAGAACAGAAGCGGCATGTTGAAGAAAATCTGGGGGATTGGGATGGGGGTATGTGTGGATTTTTCCTC

>66296_66296_4_PLEKHH2-THADA_PLEKHH2_chr2_43871935_ENST00000282406_THADA_chr2_43755127_ENST00000415080_length(amino acids)=877AA_BP=40
MAELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQ
WLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKELISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENI
IPYVADGAKAAILGFTSPVWASQMTGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRHPSMFLLLLVLERLYASPMDGTSSALSMGP
FVPFIMRCGHSPVYHSREMAARALVPFVMIDHIPNTIRTLLSTLPSCTDQCFRQNHIHGTLLQVFHLLQAYSDSKHGTNSDFQHELTDIT
VCTKAKLWLAKRQNPCLVTRAVYIDILFLLTCCLNRSAKDNQPVLESLGFWEEVRGIISGSELITGFPWAFKVPGLPQYLQSLTRLAIAA
VWAAAAKSGERETNVPISFSQLLESAFPEVRSLTLEALLEKFLAAASGLGEKGVPPLLCNMGEKFLLLAMKENHPECFCKILKILHCMDP
GEWLPQTEHCVHLTPKEFLIWTMDIASNERSEIQSVALRLASKVISHHMQTCVENRELIAAELKQWVQLVILSCEDHLPTESRLAVVEVL
TSTTPLFLTNPHPILELQDTLALWKCVLTLLQSEEQAVRDAATETVTTAMSQENTCQSTEFAFCQVDASIALALALAVLCDLLQQWDQLA
PGLPILLGWLLGESDDLVACVESMHQVEEDYLFEKAEVNFWAETLIFVKYLCKHLFCLLSKSGWRPPSPEMLCHLQRMVSEQCHLLSQFF

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Fusion Gene PPI Analysis for PLEKHH2-THADA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLEKHH2-THADA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLEKHH2-THADA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human