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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CREB1-EMC2 (FusionGDB2 ID:HG1385TG9694)

Fusion Gene Summary for CREB1-EMC2

Fusion gene summary

Fusion gene information	Fusion gene name: CREB1-EMC2
	Fusion gene ID: hg1385tg9694
		Hgene	Tgene
	Gene symbol	CREB1	EMC2
	Gene ID	1385	9694
	Gene name	cAMP responsive element binding protein 1	ER membrane protein complex subunit 2
	Synonyms	CREB\|CREB-1	KIAA0103\|TTC35
	Cytomap	('CREB1')('EMC2') 2q33.3	8q23.1
	Type of gene	protein-coding	protein-coding
	Description	cyclic AMP-responsive element-binding protein 1active transcription factor CREBcAMP-response element-binding protein-1cyclic adenosine 3',5'-monophosphate response element binding proteincyclic adenosine 3',5'-monophosphate response element-binding pr	ER membrane protein complex subunit 2TPR repeat protein 35tetratricopeptide repeat domain 35tetratricopeptide repeat protein 35
	Modification date	20200315	20200313
	UniProtAcc	P16220	.
	Ensembl transtripts involved in fusion gene	ENST00000353267, ENST00000430624, ENST00000432329, ENST00000536726, ENST00000539789, ENST00000374397, ENST00000451164,
Fusion gene scores	* DoF score	8 X 5 X 6=240	2 X 2 X 2=8
	# samples	8	2
	** MAII score	log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: CREB1 [Title/Abstract] AND EMC2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CREB1(208435045)-EMC2(109462052), # samples:1
Anticipated loss of major functional domain due to fusion event.	CREB1-EMC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CREB1-EMC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CREB1-EMC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CREB1-EMC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CREB1	GO:0006468	protein phosphorylation	8798441
Hgene	CREB1	GO:0010033	response to organic substance	8798441
Hgene	CREB1	GO:0010944	negative regulation of transcription by competitive promoter binding	19861239
Hgene	CREB1	GO:0045944	positive regulation of transcription by RNA polymerase II	1655749\|8798441\|19861239

Fusion gene breakpoints across CREB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EMC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-A4PE-01A	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+

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Fusion Gene ORF analysis for CREB1-EMC2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000353267	ENST00000520294	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+
5CDS-intron	ENST00000430624	ENST00000520294	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+
5CDS-intron	ENST00000432329	ENST00000520294	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+
5CDS-intron	ENST00000536726	ENST00000520294	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+
5CDS-intron	ENST00000539789	ENST00000520294	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+
In-frame	ENST00000353267	ENST00000220853	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+
In-frame	ENST00000430624	ENST00000220853	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+
In-frame	ENST00000432329	ENST00000220853	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+
In-frame	ENST00000536726	ENST00000220853	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+
In-frame	ENST00000539789	ENST00000220853	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+
intron-3CDS	ENST00000374397	ENST00000220853	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+
intron-3CDS	ENST00000451164	ENST00000220853	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+
intron-intron	ENST00000374397	ENST00000520294	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+
intron-intron	ENST00000451164	ENST00000520294	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000430624

CREB1

chr2

208435045

ENST00000220853

EMC2

chr8

109462052

1963

795

290

1648

452

ENST00000432329

CREB1

chr2

208435045

ENST00000220853

EMC2

chr8

109462052

1966

798

251

1651

466

ENST00000353267

CREB1

chr2

208435045

ENST00000220853

EMC2

chr8

109462052

1904

736

231

1589

452

ENST00000536726

CREB1

chr2

208435045

ENST00000220853

EMC2

chr8

109462052

1746

578

1431

452

ENST00000539789

CREB1

chr2

208435045

ENST00000220853

EMC2

chr8

109462052

1735

567

140

1420

426

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000430624	ENST00000220853	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+	0.001591218	0.99840885
ENST00000432329	ENST00000220853	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+	0.001325167	0.99867487
ENST00000353267	ENST00000220853	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+	0.001438264	0.9985618
ENST00000536726	ENST00000220853	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+	0.001737504	0.99826247
ENST00000539789	ENST00000220853	CREB1	chr2	208435045	+	EMC2	chr8	109462052	+	0.001874406	0.9981256

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Fusion Genomic Features for CREB1-EMC2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CREB1	chr2	208435045	+	EMC2	chr8	109462051	+	0.000633279	0.9993667
CREB1	chr2	208435045	+	EMC2	chr8	109462051	+	0.000633279	0.9993667

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CREB1-EMC2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:208435045/chr8:109462052)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CREB1 P16220	.
FUNCTION: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CREB1

chr2:208435045

chr8:109462052

ENST00000353267

87_146

168

328.0

Domain

KID

Hgene

CREB1

chr2:208435045

chr8:109462052

ENST00000430624

87_146

168

328.0

Domain

KID

Hgene

CREB1

chr2:208435045

chr8:109462052

ENST00000432329

87_146

182

342.0

Domain

KID

Tgene

EMC2

chr2:208435045

chr8:109462052

ENST00000220853

155_188

298.0

Repeat

TPR 2

Tgene

EMC2

chr2:208435045

chr8:109462052

ENST00000220853

192_225

298.0

Repeat

TPR 3

Tgene

EMC2

chr2:208435045

chr8:109462052

ENST00000220853

87_120

298.0

Repeat

TPR 1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CREB1

chr2:208435045

chr8:109462052

ENST00000353267

269_327

168

328.0

Domain

bZIP

Hgene

CREB1

chr2:208435045

chr8:109462052

ENST00000374397

269_327

231.0

Domain

bZIP

Hgene

CREB1

chr2:208435045

chr8:109462052

ENST00000374397

87_146

231.0

Domain

KID

Hgene

CREB1

chr2:208435045

chr8:109462052

ENST00000430624

269_327

168

328.0

Domain

bZIP

Hgene

CREB1

chr2:208435045

chr8:109462052

ENST00000432329

269_327

182

342.0

Domain

bZIP

Hgene

CREB1

chr2:208435045

chr8:109462052

ENST00000353267

270_295

168

328.0

Region

Basic motif

Hgene

CREB1

chr2:208435045

chr8:109462052

ENST00000353267

297_318

168

328.0

Region

Leucine-zipper

Hgene

CREB1

chr2:208435045

chr8:109462052

ENST00000374397

270_295

231.0

Region

Basic motif

Hgene

CREB1

chr2:208435045

chr8:109462052

ENST00000374397

297_318

231.0

Region

Leucine-zipper

Hgene

CREB1

chr2:208435045

chr8:109462052

ENST00000430624

270_295

168

328.0

Region

Basic motif

Hgene

CREB1

chr2:208435045

chr8:109462052

ENST00000430624

297_318

168

328.0

Region

Leucine-zipper

Hgene

CREB1

chr2:208435045

chr8:109462052

ENST00000432329

270_295

182

342.0

Region

Basic motif

Hgene

CREB1

chr2:208435045

chr8:109462052

ENST00000432329

297_318

182

342.0

Region

Leucine-zipper

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Fusion Gene Sequence for CREB1-EMC2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>19302_19302_1_CREB1-EMC2_CREB1_chr2_208435045_ENST00000353267_EMC2_chr8_109462052_ENST00000220853_length(transcript)=1904nt_BP=736nt
GCGCACTCGGCACTGGGCGGCGCTGGCTGGCTCCCTGGCTGCGGCTCCTCAGTCGGCGGCGGCTGCTGCTGCCTGTGGCCCGGGCGGCTG
GGAGAAGCGGAGTGTTGGTGAGTGACGCGGCGGAGGTGTAGTTTGACGCGGTGTGTTACGTGGGGGAGAGAATAAAACTCCAGCGAGATC
CGGGCCGTGAACGAAAGCAGTGACGGAGGAGCTTGTACCACCGGTAACTAAATGACCATGGAATCTGGAGCCGAGAACCAGCAGAGTGGA
GATGCAGCTGTAACAGAAGCTGAAAACCAACAAATGACAGTTCAAGCCCAGCCACAGATTGCCACATTAGCCCAGGTATCTATGCCAGCA
GCTCATGCAACATCATCTGCTCCCACCGTAACTCTAGTACAGCTGCCCAATGGGCAGACAGTTCAAGTCCATGGAGTCATTCAGGCGGCC
CAGCCATCAGTTATTCAGTCTCCACAAGTCCAAACAGTTCAGATTTCAACTATTGCAGAAAGTGAAGATTCACAGGAGTCAGTGGATAGT
GTAACTGATTCCCAAAAGCGAAGGGAAATTCTTTCAAGGAGGCCTTCCTACAGGAAAATTTTGAATGACTTATCTTCTGATGCACCAGGA
GTGCCAAGGATTGAAGAAGAGAAGTCTGAAGAGGAGACTTCAGCACCTGCCATCACCACTGTAACGGTGCCAACTCCAATTTACCAAACT
AGCAGTGGACAGTATAAAATGAGAGATAAAATGAGAAAATGGAGAGAAGAAAACTCAAGAAATAGTGAGCAAATTGTGGAAGTTGGAGAA
GAATTAATTAATGAATATGCTTCTAAGCTGGGAGATGATATTTGGATCATATATGAACAGGTGATGATTGCAGCACTAGACTATGGTCGG
GATGACTTGGCATTGTTTTGTCTTCAAGAGCTGAGAAGACAGTTCCCTGGCAGTCACAGAGTCAAGCGATTAACAGGCATGAGATTTGAA
GCCATGGAAAGATATGATGATGCTATACAGCTATATGATAGGATTTTACAAGAAGATCCAACTAACACTGCTGCAAGAAAGCGTAAGATT
GCCATTCGAAAAGCCCAGGGGAAAAATGTGGAGGCCATTCGGGAGCTGAATGAGTATCTGGAACAATTTGTTGGAGACCAAGAAGCCTGG
CATGAACTTGCAGAACTTTACATCAATGAACATGACTATGCAAAAGCAGCCTTTTGTTTAGAGGAACTAATGATGACTAATCCACACAAC
CACTTATACTGTCAGCAGTATGCTGAAGTTAAGTATACCCAAGGTGGACTTGAAAACCTCGAACTTTCAAGAAAGTATTTTGCACAGGCA
TTGAAACTGAACAACAGAAATATGAGAGCTTTGTTTGGACTTTATATGTCGGCAAGTCATATTGCTTCTAATCCAAAAGCAAGTGCAAAA
ACGAAAAAGGACAACATGAAATATGCTAGTTGGGCAGCTAGTCAAATAAACAGAGCTTATCAGTTTGCAGGTCGAAGTAAGAAGGAAACC
AAATATTCTCTTAAGGCTGTCGAAGACATGTTGGAAACATTGCAGATCACCCAGTCTTAAGGTTTCAAAAACTCTTTGACATTAGATTTC
ACAACTGCACAATTGAACTTATTGGCCTGTAACTTATTTACTAAATGCTCAGTGCTATTTATATACTACAGTAATTTTCTGTTAAGAAGG
CAGTTGTAAAGAATGTGTTTATATAAACCTAAAAATGCCTTTTACTGCTAAGTGGGGAGATGGGGGAAATCCATGGAAGAGAGATTTAAG
ACTTATTGATTGTACATCAGTCTCTTCATATCACATATACATGTATATATATAAAACTCTAATGTAGTATAACCTTGTTAAATAAACCAT

>19302_19302_1_CREB1-EMC2_CREB1_chr2_208435045_ENST00000353267_EMC2_chr8_109462052_ENST00000220853_length(amino acids)=452AA_BP=169
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQIST
IAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYKMRDKMRKWREE
NSRNSEQIVEVGEELINEYASKLGDDIWIIYEQVMIAALDYGRDDLALFCLQELRRQFPGSHRVKRLTGMRFEAMERYDDAIQLYDRILQ
EDPTNTAARKRKIAIRKAQGKNVEAIRELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMTNPHNHLYCQQYAEVKYTQGGL
ENLELSRKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKTKKDNMKYASWAASQINRAYQFAGRSKKETKYSLKAVEDMLETLQIT

--------------------------------------------------------------
>19302_19302_2_CREB1-EMC2_CREB1_chr2_208435045_ENST00000430624_EMC2_chr8_109462052_ENST00000220853_length(transcript)=1963nt_BP=795nt
AGACCACTCCTCCCGGCGCCGGGCTCAGCCCGCCTTCGCCTTCCCTCTCCCCGCGGAACCCCTTCTCGTCGCCCGAAGAAACCCGAAGGT
CTTCGGCAAGTTCCGTCCCCAGCGCGGGGGCGGGGCCGCTCGAGCTGCTCCGGGCCTAGCTCGGCTGTTTCCGTGCGCGGCCGCTGCGCA
CTCGGCACTGGGCGGCGCTGGCTGGCTCCCTGGCTGCGGCTCCTCAGTCGGCGGCGGCTGCTGCTGCCTGTGGCCCGGGCGGCTGGGAGA
AGCGGAGTGTTGGTAACTAAATGACCATGGAATCTGGAGCCGAGAACCAGCAGAGTGGAGATGCAGCTGTAACAGAAGCTGAAAACCAAC
AAATGACAGTTCAAGCCCAGCCACAGATTGCCACATTAGCCCAGGTATCTATGCCAGCAGCTCATGCAACATCATCTGCTCCCACCGTAA
CTCTAGTACAGCTGCCCAATGGGCAGACAGTTCAAGTCCATGGAGTCATTCAGGCGGCCCAGCCATCAGTTATTCAGTCTCCACAAGTCC
AAACAGTTCAGATTTCAACTATTGCAGAAAGTGAAGATTCACAGGAGTCAGTGGATAGTGTAACTGATTCCCAAAAGCGAAGGGAAATTC
TTTCAAGGAGGCCTTCCTACAGGAAAATTTTGAATGACTTATCTTCTGATGCACCAGGAGTGCCAAGGATTGAAGAAGAGAAGTCTGAAG
AGGAGACTTCAGCACCTGCCATCACCACTGTAACGGTGCCAACTCCAATTTACCAAACTAGCAGTGGACAGTATAAAATGAGAGATAAAA
TGAGAAAATGGAGAGAAGAAAACTCAAGAAATAGTGAGCAAATTGTGGAAGTTGGAGAAGAATTAATTAATGAATATGCTTCTAAGCTGG
GAGATGATATTTGGATCATATATGAACAGGTGATGATTGCAGCACTAGACTATGGTCGGGATGACTTGGCATTGTTTTGTCTTCAAGAGC
TGAGAAGACAGTTCCCTGGCAGTCACAGAGTCAAGCGATTAACAGGCATGAGATTTGAAGCCATGGAAAGATATGATGATGCTATACAGC
TATATGATAGGATTTTACAAGAAGATCCAACTAACACTGCTGCAAGAAAGCGTAAGATTGCCATTCGAAAAGCCCAGGGGAAAAATGTGG
AGGCCATTCGGGAGCTGAATGAGTATCTGGAACAATTTGTTGGAGACCAAGAAGCCTGGCATGAACTTGCAGAACTTTACATCAATGAAC
ATGACTATGCAAAAGCAGCCTTTTGTTTAGAGGAACTAATGATGACTAATCCACACAACCACTTATACTGTCAGCAGTATGCTGAAGTTA
AGTATACCCAAGGTGGACTTGAAAACCTCGAACTTTCAAGAAAGTATTTTGCACAGGCATTGAAACTGAACAACAGAAATATGAGAGCTT
TGTTTGGACTTTATATGTCGGCAAGTCATATTGCTTCTAATCCAAAAGCAAGTGCAAAAACGAAAAAGGACAACATGAAATATGCTAGTT
GGGCAGCTAGTCAAATAAACAGAGCTTATCAGTTTGCAGGTCGAAGTAAGAAGGAAACCAAATATTCTCTTAAGGCTGTCGAAGACATGT
TGGAAACATTGCAGATCACCCAGTCTTAAGGTTTCAAAAACTCTTTGACATTAGATTTCACAACTGCACAATTGAACTTATTGGCCTGTA
ACTTATTTACTAAATGCTCAGTGCTATTTATATACTACAGTAATTTTCTGTTAAGAAGGCAGTTGTAAAGAATGTGTTTATATAAACCTA
AAAATGCCTTTTACTGCTAAGTGGGGAGATGGGGGAAATCCATGGAAGAGAGATTTAAGACTTATTGATTGTACATCAGTCTCTTCATAT

>19302_19302_2_CREB1-EMC2_CREB1_chr2_208435045_ENST00000430624_EMC2_chr8_109462052_ENST00000220853_length(amino acids)=452AA_BP=169
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQIST
IAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYKMRDKMRKWREE
NSRNSEQIVEVGEELINEYASKLGDDIWIIYEQVMIAALDYGRDDLALFCLQELRRQFPGSHRVKRLTGMRFEAMERYDDAIQLYDRILQ
EDPTNTAARKRKIAIRKAQGKNVEAIRELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMTNPHNHLYCQQYAEVKYTQGGL
ENLELSRKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKTKKDNMKYASWAASQINRAYQFAGRSKKETKYSLKAVEDMLETLQIT

--------------------------------------------------------------
>19302_19302_3_CREB1-EMC2_CREB1_chr2_208435045_ENST00000432329_EMC2_chr8_109462052_ENST00000220853_length(transcript)=1966nt_BP=798nt
TGTTTCCGTGCGCGGCCGCTGCGCACTCGGCACTGGGCGGCGCTGGCTGGCTCCCTGGCTGCGGCTCCTCAGTCGGCGGCGGCTGCTGCT
GCCTGTGGCCCGGGCGGCTGGGAGAAGCGGAGTGTTGGTGAGTGACGCGGCGGAGGTGTAGTTTGACGCGGTGTGTTACGTGGGGGAGAG
AATAAAACTCCAGCGAGATCCGGGCCGTGAACGAAAGCAGTGACGGAGGAGCTTGTACCACCGGTAACTAAATGACCATGGAATCTGGAG
CCGAGAACCAGCAGAGTGGAGATGCAGCTGTAACAGAAGCTGAAAACCAACAAATGACAGTTCAAGCCCAGCCACAGATTGCCACATTAG
CCCAGGTATCTATGCCAGCAGCTCATGCAACATCATCTGCTCCCACCGTAACTCTAGTACAGCTGCCCAATGGGCAGACAGTTCAAGTCC
ATGGAGTCATTCAGGCGGCCCAGCCATCAGTTATTCAGTCTCCACAAGTCCAAACAGTTCAGTCTTCCTGTAAGGACTTAAAAAGACTTT
TCTCCGGAACACAGATTTCAACTATTGCAGAAAGTGAAGATTCACAGGAGTCAGTGGATAGTGTAACTGATTCCCAAAAGCGAAGGGAAA
TTCTTTCAAGGAGGCCTTCCTACAGGAAAATTTTGAATGACTTATCTTCTGATGCACCAGGAGTGCCAAGGATTGAAGAAGAGAAGTCTG
AAGAGGAGACTTCAGCACCTGCCATCACCACTGTAACGGTGCCAACTCCAATTTACCAAACTAGCAGTGGACAGTATAAAATGAGAGATA
AAATGAGAAAATGGAGAGAAGAAAACTCAAGAAATAGTGAGCAAATTGTGGAAGTTGGAGAAGAATTAATTAATGAATATGCTTCTAAGC
TGGGAGATGATATTTGGATCATATATGAACAGGTGATGATTGCAGCACTAGACTATGGTCGGGATGACTTGGCATTGTTTTGTCTTCAAG
AGCTGAGAAGACAGTTCCCTGGCAGTCACAGAGTCAAGCGATTAACAGGCATGAGATTTGAAGCCATGGAAAGATATGATGATGCTATAC
AGCTATATGATAGGATTTTACAAGAAGATCCAACTAACACTGCTGCAAGAAAGCGTAAGATTGCCATTCGAAAAGCCCAGGGGAAAAATG
TGGAGGCCATTCGGGAGCTGAATGAGTATCTGGAACAATTTGTTGGAGACCAAGAAGCCTGGCATGAACTTGCAGAACTTTACATCAATG
AACATGACTATGCAAAAGCAGCCTTTTGTTTAGAGGAACTAATGATGACTAATCCACACAACCACTTATACTGTCAGCAGTATGCTGAAG
TTAAGTATACCCAAGGTGGACTTGAAAACCTCGAACTTTCAAGAAAGTATTTTGCACAGGCATTGAAACTGAACAACAGAAATATGAGAG
CTTTGTTTGGACTTTATATGTCGGCAAGTCATATTGCTTCTAATCCAAAAGCAAGTGCAAAAACGAAAAAGGACAACATGAAATATGCTA
GTTGGGCAGCTAGTCAAATAAACAGAGCTTATCAGTTTGCAGGTCGAAGTAAGAAGGAAACCAAATATTCTCTTAAGGCTGTCGAAGACA
TGTTGGAAACATTGCAGATCACCCAGTCTTAAGGTTTCAAAAACTCTTTGACATTAGATTTCACAACTGCACAATTGAACTTATTGGCCT
GTAACTTATTTACTAAATGCTCAGTGCTATTTATATACTACAGTAATTTTCTGTTAAGAAGGCAGTTGTAAAGAATGTGTTTATATAAAC
CTAAAAATGCCTTTTACTGCTAAGTGGGGAGATGGGGGAAATCCATGGAAGAGAGATTTAAGACTTATTGATTGTACATCAGTCTCTTCA

>19302_19302_3_CREB1-EMC2_CREB1_chr2_208435045_ENST00000432329_EMC2_chr8_109462052_ENST00000220853_length(amino acids)=466AA_BP=183
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQSSC
KDLKRLFSGTQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSG
QYKMRDKMRKWREENSRNSEQIVEVGEELINEYASKLGDDIWIIYEQVMIAALDYGRDDLALFCLQELRRQFPGSHRVKRLTGMRFEAME
RYDDAIQLYDRILQEDPTNTAARKRKIAIRKAQGKNVEAIRELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMTNPHNHLY
CQQYAEVKYTQGGLENLELSRKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKTKKDNMKYASWAASQINRAYQFAGRSKKETKYS

--------------------------------------------------------------
>19302_19302_4_CREB1-EMC2_CREB1_chr2_208435045_ENST00000536726_EMC2_chr8_109462052_ENST00000220853_length(transcript)=1746nt_BP=578nt
AGAATAAAACTCCAGCGAGATCCGGGCCGTGAACGAAAGCAGTGACGGAGGAGCTTGTACCACCGGTAACTAAATGACCATGGAATCTGG
AGCCGAGAACCAGCAGAGTGGAGATGCAGCTGTAACAGAAGCTGAAAACCAACAAATGACAGTTCAAGCCCAGCCACAGATTGCCACATT
AGCCCAGGTATCTATGCCAGCAGCTCATGCAACATCATCTGCTCCCACCGTAACTCTAGTACAGCTGCCCAATGGGCAGACAGTTCAAGT
CCATGGAGTCATTCAGGCGGCCCAGCCATCAGTTATTCAGTCTCCACAAGTCCAAACAGTTCAGATTTCAACTATTGCAGAAAGTGAAGA
TTCACAGGAGTCAGTGGATAGTGTAACTGATTCCCAAAAGCGAAGGGAAATTCTTTCAAGGAGGCCTTCCTACAGGAAAATTTTGAATGA
CTTATCTTCTGATGCACCAGGAGTGCCAAGGATTGAAGAAGAGAAGTCTGAAGAGGAGACTTCAGCACCTGCCATCACCACTGTAACGGT
GCCAACTCCAATTTACCAAACTAGCAGTGGACAGTATAAAATGAGAGATAAAATGAGAAAATGGAGAGAAGAAAACTCAAGAAATAGTGA
GCAAATTGTGGAAGTTGGAGAAGAATTAATTAATGAATATGCTTCTAAGCTGGGAGATGATATTTGGATCATATATGAACAGGTGATGAT
TGCAGCACTAGACTATGGTCGGGATGACTTGGCATTGTTTTGTCTTCAAGAGCTGAGAAGACAGTTCCCTGGCAGTCACAGAGTCAAGCG
ATTAACAGGCATGAGATTTGAAGCCATGGAAAGATATGATGATGCTATACAGCTATATGATAGGATTTTACAAGAAGATCCAACTAACAC
TGCTGCAAGAAAGCGTAAGATTGCCATTCGAAAAGCCCAGGGGAAAAATGTGGAGGCCATTCGGGAGCTGAATGAGTATCTGGAACAATT
TGTTGGAGACCAAGAAGCCTGGCATGAACTTGCAGAACTTTACATCAATGAACATGACTATGCAAAAGCAGCCTTTTGTTTAGAGGAACT
AATGATGACTAATCCACACAACCACTTATACTGTCAGCAGTATGCTGAAGTTAAGTATACCCAAGGTGGACTTGAAAACCTCGAACTTTC
AAGAAAGTATTTTGCACAGGCATTGAAACTGAACAACAGAAATATGAGAGCTTTGTTTGGACTTTATATGTCGGCAAGTCATATTGCTTC
TAATCCAAAAGCAAGTGCAAAAACGAAAAAGGACAACATGAAATATGCTAGTTGGGCAGCTAGTCAAATAAACAGAGCTTATCAGTTTGC
AGGTCGAAGTAAGAAGGAAACCAAATATTCTCTTAAGGCTGTCGAAGACATGTTGGAAACATTGCAGATCACCCAGTCTTAAGGTTTCAA
AAACTCTTTGACATTAGATTTCACAACTGCACAATTGAACTTATTGGCCTGTAACTTATTTACTAAATGCTCAGTGCTATTTATATACTA
CAGTAATTTTCTGTTAAGAAGGCAGTTGTAAAGAATGTGTTTATATAAACCTAAAAATGCCTTTTACTGCTAAGTGGGGAGATGGGGGAA
ATCCATGGAAGAGAGATTTAAGACTTATTGATTGTACATCAGTCTCTTCATATCACATATACATGTATATATATAAAACTCTAATGTAGT

>19302_19302_4_CREB1-EMC2_CREB1_chr2_208435045_ENST00000536726_EMC2_chr8_109462052_ENST00000220853_length(amino acids)=452AA_BP=169
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQIST
IAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYKMRDKMRKWREE
NSRNSEQIVEVGEELINEYASKLGDDIWIIYEQVMIAALDYGRDDLALFCLQELRRQFPGSHRVKRLTGMRFEAMERYDDAIQLYDRILQ
EDPTNTAARKRKIAIRKAQGKNVEAIRELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMTNPHNHLYCQQYAEVKYTQGGL
ENLELSRKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKTKKDNMKYASWAASQINRAYQFAGRSKKETKYSLKAVEDMLETLQIT

--------------------------------------------------------------
>19302_19302_5_CREB1-EMC2_CREB1_chr2_208435045_ENST00000539789_EMC2_chr8_109462052_ENST00000220853_length(transcript)=1735nt_BP=567nt
ATACATCATACAGTAACACACTTATGTGCACCATTGGTGCTGAGCTGCTGGTTATCCCACTCTGCCATGTGTGCTGTTTCTCTTTGCTTT
TGCCACTACTCCACTCTGTGCTTGAAATTCTGTGACTCTTCCCTGTATCTATGCCAGCAGCTCATGCAACATCATCTGCTCCCACCGTAA
CTCTAGTACAGCTGCCCAATGGGCAGACAGTTCAAGTCCATGGAGTCATTCAGGCGGCCCAGCCATCAGTTATTCAGTCTCCACAAGTCC
AAACAGTTCAGTCTTCCTGTAAGGACTTAAAAAGACTTTTCTCCGGAACACAGATTTCAACTATTGCAGAAAGTGAAGATTCACAGGAGT
CAGTGGATAGTGTAACTGATTCCCAAAAGCGAAGGGAAATTCTTTCAAGGAGGCCTTCCTACAGGAAAATTTTGAATGACTTATCTTCTG
ATGCACCAGGAGTGCCAAGGATTGAAGAAGAGAAGTCTGAAGAGGAGACTTCAGCACCTGCCATCACCACTGTAACGGTGCCAACTCCAA
TTTACCAAACTAGCAGTGGACAGTATAAAATGAGAGATAAAATGAGAAAATGGAGAGAAGAAAACTCAAGAAATAGTGAGCAAATTGTGG
AAGTTGGAGAAGAATTAATTAATGAATATGCTTCTAAGCTGGGAGATGATATTTGGATCATATATGAACAGGTGATGATTGCAGCACTAG
ACTATGGTCGGGATGACTTGGCATTGTTTTGTCTTCAAGAGCTGAGAAGACAGTTCCCTGGCAGTCACAGAGTCAAGCGATTAACAGGCA
TGAGATTTGAAGCCATGGAAAGATATGATGATGCTATACAGCTATATGATAGGATTTTACAAGAAGATCCAACTAACACTGCTGCAAGAA
AGCGTAAGATTGCCATTCGAAAAGCCCAGGGGAAAAATGTGGAGGCCATTCGGGAGCTGAATGAGTATCTGGAACAATTTGTTGGAGACC
AAGAAGCCTGGCATGAACTTGCAGAACTTTACATCAATGAACATGACTATGCAAAAGCAGCCTTTTGTTTAGAGGAACTAATGATGACTA
ATCCACACAACCACTTATACTGTCAGCAGTATGCTGAAGTTAAGTATACCCAAGGTGGACTTGAAAACCTCGAACTTTCAAGAAAGTATT
TTGCACAGGCATTGAAACTGAACAACAGAAATATGAGAGCTTTGTTTGGACTTTATATGTCGGCAAGTCATATTGCTTCTAATCCAAAAG
CAAGTGCAAAAACGAAAAAGGACAACATGAAATATGCTAGTTGGGCAGCTAGTCAAATAAACAGAGCTTATCAGTTTGCAGGTCGAAGTA
AGAAGGAAACCAAATATTCTCTTAAGGCTGTCGAAGACATGTTGGAAACATTGCAGATCACCCAGTCTTAAGGTTTCAAAAACTCTTTGA
CATTAGATTTCACAACTGCACAATTGAACTTATTGGCCTGTAACTTATTTACTAAATGCTCAGTGCTATTTATATACTACAGTAATTTTC
TGTTAAGAAGGCAGTTGTAAAGAATGTGTTTATATAAACCTAAAAATGCCTTTTACTGCTAAGTGGGGAGATGGGGGAAATCCATGGAAG
AGAGATTTAAGACTTATTGATTGTACATCAGTCTCTTCATATCACATATACATGTATATATATAAAACTCTAATGTAGTATAACCTTGTT

>19302_19302_5_CREB1-EMC2_CREB1_chr2_208435045_ENST00000539789_EMC2_chr8_109462052_ENST00000220853_length(amino acids)=426AA_BP=143
MPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQSSCKDLKRLFSGTQISTIAESEDSQESVDSVTDSQKRREILSR
RPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYKMRDKMRKWREENSRNSEQIVEVGEELINEYASKLGDD
IWIIYEQVMIAALDYGRDDLALFCLQELRRQFPGSHRVKRLTGMRFEAMERYDDAIQLYDRILQEDPTNTAARKRKIAIRKAQGKNVEAI
RELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMTNPHNHLYCQQYAEVKYTQGGLENLELSRKYFAQALKLNNRNMRALFG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CREB1-EMC2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CREB1-EMC2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	CREB1	P16220	DB00131	Adenosine phosphate	Activator	Small molecule	Approved\|Investigational\|Nutraceutical
Hgene	CREB1	P16220	DB01183	Naloxone	Other/unknown	Small molecule	Approved\|Vet_approved

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Related Diseases for CREB1-EMC2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CREB1	C0011570	Mental Depression	5	PSYGENET
Hgene	CREB1	C0011581	Depressive disorder	5	PSYGENET
Hgene	CREB1	C0041696	Unipolar Depression	5	PSYGENET
Hgene	CREB1	C0525045	Mood Disorders	5	PSYGENET
Hgene	CREB1	C1269683	Major Depressive Disorder	5	PSYGENET
Hgene	CREB1	C0600427	Cocaine Dependence	4	CTD_human;PSYGENET
Hgene	CREB1	C0001973	Alcoholic Intoxication, Chronic	3	PSYGENET
Hgene	CREB1	C0005586	Bipolar Disorder	3	PSYGENET
Hgene	CREB1	C0009171	Cocaine Abuse	3	CTD_human
Hgene	CREB1	C0036341	Schizophrenia	3	PSYGENET
Hgene	CREB1	C0236736	Cocaine-Related Disorders	3	CTD_human
Hgene	CREB1	C0026552	Morphine Dependence	1	CTD_human
Hgene	CREB1	C0027051	Myocardial Infarction	1	CTD_human
Hgene	CREB1	C0027627	Neoplasm Metastasis	1	CTD_human
Hgene	CREB1	C0038587	Substance Withdrawal Syndrome	1	CTD_human
Hgene	CREB1	C0086189	Drug Withdrawal Symptoms	1	CTD_human
Hgene	CREB1	C0087169	Withdrawal Symptoms	1	CTD_human
Hgene	CREB1	C0151779	Cutaneous Melanoma	1	CTD_human
Hgene	CREB1	C0206651	Clear Cell Sarcoma of Soft Tissue	1	ORPHANET
Hgene	CREB1	C0600272	Morphine Abuse	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:CREB1-EMC2 (FusionGDB2 ID:HG1385TG9694)

Fusion Gene Summary for CREB1-EMC2

Fusion Gene ORF analysis for CREB1-EMC2

Fusion Genomic Features for CREB1-EMC2

Fusion Protein Features for CREB1-EMC2

Fusion Gene Sequence for CREB1-EMC2

Fusion Gene PPI Analysis for CREB1-EMC2

Related Drugs for CREB1-EMC2

Related Diseases for CREB1-EMC2

Fusion Gene Studies
in Kim Lab