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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CRHR1-GNAS (FusionGDB2 ID:HG1394TG2778)

Fusion Gene Summary for CRHR1-GNAS

Fusion gene summary

Fusion gene information	Fusion gene name: CRHR1-GNAS
	Fusion gene ID: hg1394tg2778
		Hgene	Tgene
	Gene symbol	CRHR1	GNAS
	Gene ID	1394	2778
	Gene name	corticotropin releasing hormone receptor 1	GNAS complex locus
	Synonyms	CRF-R\|CRF-R-1\|CRF-R1\|CRF1\|CRFR-1\|CRFR1\|CRH-R-1\|CRH-R1\|CRHR\|CRHR1L	AHO\|C20orf45\|GNAS1\|GPSA\|GSA\|GSP\|NESP\|PITA3\|POH\|SCG6\|SgVI
	Cytomap	('CRHR1')('GNAS') 17q21.31	20q13.32
	Type of gene	protein-coding	protein-coding
	Description	corticotropin-releasing factor receptor 1CRH receptor 1corticotropin-releasing factor type 1 receptorseven transmembrane helix receptor	protein ALEXprotein GNASprotein SCG6 (secretogranin VI)G protein subunit alpha Sadenylate cyclase-stimulating G alpha proteinalternative gene product encoded by XL-exonextra large alphas proteinguanine nucleotide binding protein (G protein), alpha
	Modification date	20200313	20200329
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000293493, ENST00000339069, ENST00000314537, ENST00000352855, ENST00000398285, ENST00000547258, ENST00000548791, ENST00000550606, ENST00000551221, ENST00000551817, ENST00000552724, ENST00000577353,
Fusion gene scores	* DoF score	13 X 3 X 7=273	111 X 41 X 18=81918
	# samples	16	111
	** MAII score	log2(16/273*10)=-0.77082904603249 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(111/81918*10)=-6.20554891117303 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CRHR1 [Title/Abstract] AND GNAS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CRHR1(43699407)-GNAS(57470666), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CRHR1	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	18292205
Hgene	CRHR1	GO:0071376	cellular response to corticotropin-releasing hormone stimulus	18292205
Hgene	CRHR1	GO:1901386	negative regulation of voltage-gated calcium channel activity	18292205

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4HD	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+

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Fusion Gene ORF analysis for CRHR1-GNAS

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3UTR	ENST00000293493	ENST00000313949	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-3UTR	ENST00000293493	ENST00000371075	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-3UTR	ENST00000293493	ENST00000371098	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-3UTR	ENST00000293493	ENST00000371100	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-3UTR	ENST00000293493	ENST00000464624	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-3UTR	ENST00000339069	ENST00000313949	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-3UTR	ENST00000339069	ENST00000371075	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-3UTR	ENST00000339069	ENST00000371098	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-3UTR	ENST00000339069	ENST00000371100	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-3UTR	ENST00000339069	ENST00000464624	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-intron	ENST00000293493	ENST00000265620	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-intron	ENST00000293493	ENST00000306090	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-intron	ENST00000293493	ENST00000306120	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-intron	ENST00000293493	ENST00000354359	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-intron	ENST00000293493	ENST00000371081	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-intron	ENST00000293493	ENST00000371085	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-intron	ENST00000293493	ENST00000371095	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-intron	ENST00000293493	ENST00000371099	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-intron	ENST00000293493	ENST00000371102	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-intron	ENST00000339069	ENST00000265620	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-intron	ENST00000339069	ENST00000306090	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-intron	ENST00000339069	ENST00000306120	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-intron	ENST00000339069	ENST00000354359	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-intron	ENST00000339069	ENST00000371081	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-intron	ENST00000339069	ENST00000371085	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-intron	ENST00000339069	ENST00000371095	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-intron	ENST00000339069	ENST00000371099	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
5UTR-intron	ENST00000339069	ENST00000371102	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000314537	ENST00000313949	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000314537	ENST00000371075	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000314537	ENST00000371098	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000314537	ENST00000371100	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000314537	ENST00000464624	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000352855	ENST00000313949	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000352855	ENST00000371075	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000352855	ENST00000371098	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000352855	ENST00000371100	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000352855	ENST00000464624	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000398285	ENST00000313949	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000398285	ENST00000371075	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000398285	ENST00000371098	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000398285	ENST00000371100	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000398285	ENST00000464624	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000547258	ENST00000313949	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000547258	ENST00000371075	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000547258	ENST00000371098	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000547258	ENST00000371100	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000547258	ENST00000464624	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000548791	ENST00000313949	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000548791	ENST00000371075	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000548791	ENST00000371098	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000548791	ENST00000371100	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000548791	ENST00000464624	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000550606	ENST00000313949	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000550606	ENST00000371075	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000550606	ENST00000371098	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000550606	ENST00000371100	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000550606	ENST00000464624	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000551221	ENST00000313949	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000551221	ENST00000371075	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000551221	ENST00000371098	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000551221	ENST00000371100	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000551221	ENST00000464624	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000551817	ENST00000313949	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000551817	ENST00000371075	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000551817	ENST00000371098	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000551817	ENST00000371100	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000551817	ENST00000464624	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000552724	ENST00000313949	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000552724	ENST00000371075	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000552724	ENST00000371098	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000552724	ENST00000371100	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000552724	ENST00000464624	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000577353	ENST00000313949	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000577353	ENST00000371075	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000577353	ENST00000371098	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000577353	ENST00000371100	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-3UTR	ENST00000577353	ENST00000464624	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000314537	ENST00000265620	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000314537	ENST00000306090	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000314537	ENST00000306120	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000314537	ENST00000354359	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000314537	ENST00000371081	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000314537	ENST00000371085	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000314537	ENST00000371095	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000314537	ENST00000371099	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000314537	ENST00000371102	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000352855	ENST00000265620	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000352855	ENST00000306090	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000352855	ENST00000306120	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000352855	ENST00000354359	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000352855	ENST00000371081	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000352855	ENST00000371085	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000352855	ENST00000371095	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000352855	ENST00000371099	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000352855	ENST00000371102	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000398285	ENST00000265620	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000398285	ENST00000306090	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000398285	ENST00000306120	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000398285	ENST00000354359	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000398285	ENST00000371081	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000398285	ENST00000371085	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000398285	ENST00000371095	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000398285	ENST00000371099	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000398285	ENST00000371102	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000547258	ENST00000265620	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000547258	ENST00000306090	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000547258	ENST00000306120	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000547258	ENST00000354359	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000547258	ENST00000371081	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000547258	ENST00000371085	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000547258	ENST00000371095	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000547258	ENST00000371099	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000547258	ENST00000371102	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000548791	ENST00000265620	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000548791	ENST00000306090	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000548791	ENST00000306120	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000548791	ENST00000354359	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000548791	ENST00000371081	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000548791	ENST00000371085	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000548791	ENST00000371095	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000548791	ENST00000371099	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000548791	ENST00000371102	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000550606	ENST00000265620	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000550606	ENST00000306090	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000550606	ENST00000306120	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000550606	ENST00000354359	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000550606	ENST00000371081	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000550606	ENST00000371085	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000550606	ENST00000371095	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000550606	ENST00000371099	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000550606	ENST00000371102	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000551221	ENST00000265620	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000551221	ENST00000306090	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000551221	ENST00000306120	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000551221	ENST00000354359	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000551221	ENST00000371081	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000551221	ENST00000371085	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000551221	ENST00000371095	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000551221	ENST00000371099	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000551221	ENST00000371102	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000551817	ENST00000265620	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000551817	ENST00000306090	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000551817	ENST00000306120	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000551817	ENST00000354359	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000551817	ENST00000371081	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000551817	ENST00000371085	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000551817	ENST00000371095	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000551817	ENST00000371099	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000551817	ENST00000371102	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000552724	ENST00000265620	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000552724	ENST00000306090	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000552724	ENST00000306120	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000552724	ENST00000354359	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000552724	ENST00000371081	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000552724	ENST00000371085	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000552724	ENST00000371095	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000552724	ENST00000371099	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000552724	ENST00000371102	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000577353	ENST00000265620	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000577353	ENST00000306090	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000577353	ENST00000306120	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000577353	ENST00000354359	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000577353	ENST00000371081	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000577353	ENST00000371085	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000577353	ENST00000371095	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000577353	ENST00000371099	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+
intron-intron	ENST00000577353	ENST00000371102	CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for CRHR1-GNAS

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+	1.14E-06	0.9999988
CRHR1	chr17	43699407	+	GNAS	chr20	57470666	+	1.14E-06	0.9999988

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CRHR1-GNAS

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:43699407/:57470666)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CRHR1-GNAS

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CRHR1-GNAS

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CRHR1-GNAS

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CRHR1-GNAS

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CRHR1	C0001973	Alcoholic Intoxication, Chronic	5	PSYGENET
Hgene	CRHR1	C0011570	Mental Depression	5	PSYGENET
Hgene	CRHR1	C0011581	Depressive disorder	5	PSYGENET
Hgene	CRHR1	C0041696	Unipolar Depression	5	PSYGENET
Hgene	CRHR1	C0525045	Mood Disorders	5	PSYGENET
Hgene	CRHR1	C1269683	Major Depressive Disorder	5	CTD_human;PSYGENET
Hgene	CRHR1	C0005586	Bipolar Disorder	4	PSYGENET
Hgene	CRHR1	C0003469	Anxiety Disorders	2	CTD_human
Hgene	CRHR1	C0376280	Anxiety States, Neurotic	2	CTD_human
Hgene	CRHR1	C1279420	Anxiety neurosis (finding)	2	CTD_human
Hgene	CRHR1	C0003123	Anorexia	1	CTD_human
Hgene	CRHR1	C0006142	Malignant neoplasm of breast	1	CTD_human
Hgene	CRHR1	C0009171	Cocaine Abuse	1	CTD_human
Hgene	CRHR1	C0011574	Involutional Depression	1	CTD_human
Hgene	CRHR1	C0011616	Contact Dermatitis	1	CTD_human
Hgene	CRHR1	C0020429	Hyperalgesia	1	CTD_human
Hgene	CRHR1	C0029410	Osteoarthritis of hip	1	CTD_human
Hgene	CRHR1	C0030201	Pain, Postoperative	1	CTD_human
Hgene	CRHR1	C0033975	Psychotic Disorders	1	PSYGENET
Hgene	CRHR1	C0162351	Contact hypersensitivity	1	CTD_human
Hgene	CRHR1	C0178417	Anhedonia	1	PSYGENET
Hgene	CRHR1	C0236736	Cocaine-Related Disorders	1	CTD_human
Hgene	CRHR1	C0349204	Nonorganic psychosis	1	PSYGENET
Hgene	CRHR1	C0458247	Allodynia	1	CTD_human
Hgene	CRHR1	C0600427	Cocaine Dependence	1	CTD_human
Hgene	CRHR1	C0678222	Breast Carcinoma	1	CTD_human
Hgene	CRHR1	C0751211	Hyperalgesia, Primary	1	CTD_human
Hgene	CRHR1	C0751212	Hyperalgesia, Secondary	1	CTD_human
Hgene	CRHR1	C0751213	Tactile Allodynia	1	CTD_human
Hgene	CRHR1	C0751214	Hyperalgesia, Thermal	1	CTD_human
Hgene	CRHR1	C0751217	Hyperkinesia, Generalized	1	CTD_human
Hgene	CRHR1	C1257931	Mammary Neoplasms, Human	1	CTD_human
Hgene	CRHR1	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	CRHR1	C1571983	Involutional paraphrenia	1	CTD_human
Hgene	CRHR1	C1571984	Psychosis, Involutional	1	CTD_human
Hgene	CRHR1	C2936719	Mechanical Allodynia	1	CTD_human
Hgene	CRHR1	C3887506	Hyperkinesia	1	CTD_human
Hgene	CRHR1	C4704874	Mammary Carcinoma, Human	1	CTD_human
Tgene		C3494506	Pseudohypoparathyroidism, Type Ia	17	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0242292	McCune-Albright Syndrome	7	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0016065	Polyostotic fibrous dysplasia	5	CTD_human;ORPHANET
Tgene		C1864100	PSEUDOHYPOPARATHYROIDISM, TYPE IB	5	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene		C2931404	Albright's hereditary osteodystrophy	4	CTD_human;GENOMICS_ENGLAND
Tgene		C0033806	Pseudohypoparathyroidism	3	CTD_human
Tgene		C0334041	Osteoma cutis	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0014130	Endocrine System Diseases	2	CTD_human
Tgene		C0016064	Fibrous Dysplasia, Monostotic	2	ORPHANET
Tgene		C0034013	Precocious Puberty	2	CTD_human
Tgene		C0221263	Cafe-au-Lait Spots	2	CTD_human
Tgene		C0271527	Cryptogenic sexual precocity	2	CTD_human
Tgene		C0342543	Central Precocious Puberty	2	CTD_human
Tgene		C1504412	Testotoxicosis	2	CTD_human
Tgene		C1857451	Acth-Independent Macronodular Adrenal Hyperplasia	2	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C2932716	Pseudohypoparathyroidism Type 1C	2	GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0001206	Acromegaly	1	CTD_human
Tgene		C0001624	Adrenal Gland Neoplasms	1	CTD_human
Tgene		C0003129	Anoxemia	1	CTD_human
Tgene		C0003130	Anoxia	1	CTD_human
Tgene		C0008370	Cholestasis	1	GENOMICS_ENGLAND
Tgene		C0009438	Common Bile Duct Calculi	1	CTD_human
Tgene		C0011573	Endogenous depression	1	PSYGENET
Tgene		C0019087	Hemorrhagic Disorders	1	CTD_human
Tgene		C0020538	Hypertensive disease	1	CTD_human
Tgene		C0020796	Profound Mental Retardation	1	CTD_human
Tgene		C0021655	Insulin Resistance	1	CTD_human
Tgene		C0023897	Liver Diseases, Parasitic	1	CTD_human
Tgene		C0025363	Mental Retardation, Psychosocial	1	CTD_human
Tgene		C0027819	Neuroblastoma	1	CTD_human
Tgene		C0028754	Obesity	1	CTD_human
Tgene		C0029396	Heterotopic Ossification	1	CTD_human
Tgene		C0032460	Polycystic Ovary Syndrome	1	CTD_human
Tgene		C0033835	Pseudopseudohypoparathyroidism	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene		C0035204	Respiration Disorders	1	CTD_human
Tgene		C0036341	Schizophrenia	1	PSYGENET
Tgene		C0038587	Substance Withdrawal Syndrome	1	CTD_human
Tgene		C0039231	Tachycardia	1	CTD_human
Tgene		C0080203	Tachyarrhythmia	1	CTD_human
Tgene		C0086189	Drug Withdrawal Symptoms	1	CTD_human
Tgene		C0087169	Withdrawal Symptoms	1	CTD_human
Tgene		C0206698	Cholangiocarcinoma	1	CTD_human
Tgene		C0221357	Brachydactyly	1	CTD_human
Tgene		C0242184	Hypoxia	1	CTD_human
Tgene		C0242216	Biliary calculi	1	CTD_human
Tgene		C0345905	Intrahepatic Cholangiocarcinoma	1	CTD_human
Tgene		C0346302	Growth Hormone-Secreting Pituitary Adenoma	1	CTD_human
Tgene		C0700292	Hypoxemia	1	CTD_human
Tgene		C0750887	Adrenal Cancer	1	CTD_human
Tgene		C0917816	Mental deficiency	1	CTD_human
Tgene		C0920563	Insulin Sensitivity	1	CTD_human
Tgene		C1136382	Sclerocystic Ovaries	1	CTD_human
Tgene		C2932715	Pseudohypoparathyroidism Type 1B	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene		C3489630	Somatotrophinoma, Familial	1	CTD_human
Tgene		C3697137	Fibrous dysplasia of bone with intramuscular myxoma	1	ORPHANET
Tgene		C3714756	Intellectual Disability	1	CTD_human
Tgene		C3805278	Extrahepatic Cholangiocarcinoma	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:CRHR1-GNAS (FusionGDB2 ID:HG1394TG2778)

Fusion Gene Summary for CRHR1-GNAS

Fusion Gene ORF analysis for CRHR1-GNAS

Fusion Genomic Features for CRHR1-GNAS

Fusion Protein Features for CRHR1-GNAS

Fusion Gene Sequence for CRHR1-GNAS

Fusion Gene PPI Analysis for CRHR1-GNAS

Related Drugs for CRHR1-GNAS

Related Diseases for CRHR1-GNAS

Fusion Gene Studies
in Kim Lab