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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:MACROD2-DCLK2 (FusionGDB2 ID:HG140733TG166614)

Fusion Gene Summary for MACROD2-DCLK2

Fusion gene summary

Fusion gene information	Fusion gene name: MACROD2-DCLK2
	Fusion gene ID: hg140733tg166614
		Hgene	Tgene
	Gene symbol	MACROD2	DCLK2
	Gene ID	140733	166614
	Gene name	mono-ADP ribosylhydrolase 2	doublecortin like kinase 2
	Synonyms	C20orf133\|C2orf133	CL2\|CLICK-II\|CLICK2\|CLIK2\|DCAMKL2\|DCDC3\|DCDC3B\|DCK2
	Cytomap	('MACROD2')('DCLK2') 20p12.1	4q31.23-q31.3
	Type of gene	protein-coding	protein-coding
	Description	ADP-ribose glycohydrolase MACROD2MACRO domain containing 2MACRO domain-containing protein 2O-acetyl-ADP-ribose deacetylase MACROD2[Protein ADP-ribosylaspartate] hydrolase MACROD2[Protein ADP-ribosylglutamate] hydrolase[Protein ADP-ribosylglutamate]	serine/threonine-protein kinase DCLK2CaMK-like CREB regulatory kinase 2doublecortin and CaM kinase-like 2doublecortin domain-containing protein 3Bdoublecortin-like and CAM kinase-like 2
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000217246, ENST00000310348, ENST00000378058, ENST00000402914, ENST00000407045, ENST00000464883,
Fusion gene scores	* DoF score	22 X 20 X 10=4400	2 X 1 X 2=4
	# samples	25	2
	** MAII score	log2(25/4400*10)=-4.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/4*10)=2.32192809488736
Context	PubMed: MACROD2 [Title/Abstract] AND DCLK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MACROD2(13983050)-DCLK2(151023630), # samples:2
Anticipated loss of major functional domain due to fusion event.	MACROD2-DCLK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MACROD2-DCLK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MACROD2-DCLK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MACROD2-DCLK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MACROD2	GO:0042278	purine nucleoside metabolic process	21257746
Hgene	MACROD2	GO:0051725	protein de-ADP-ribosylation	23474712

Fusion gene breakpoints across MACROD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DCLK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-C8-A1HN-01A	MACROD2	chr20	13983050	-	DCLK2	chr4	151023630	+
ChimerDB4	BRCA	TCGA-C8-A1HN-01A	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+

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Fusion Gene ORF analysis for MACROD2-DCLK2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000217246	ENST00000507694	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
5CDS-intron	ENST00000310348	ENST00000507694	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
In-frame	ENST00000217246	ENST00000296550	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
In-frame	ENST00000217246	ENST00000302176	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
In-frame	ENST00000217246	ENST00000506325	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
In-frame	ENST00000310348	ENST00000296550	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
In-frame	ENST00000310348	ENST00000302176	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
In-frame	ENST00000310348	ENST00000506325	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
intron-3CDS	ENST00000378058	ENST00000296550	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
intron-3CDS	ENST00000378058	ENST00000302176	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
intron-3CDS	ENST00000378058	ENST00000506325	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
intron-3CDS	ENST00000402914	ENST00000296550	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
intron-3CDS	ENST00000402914	ENST00000302176	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
intron-3CDS	ENST00000402914	ENST00000506325	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
intron-3CDS	ENST00000407045	ENST00000296550	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
intron-3CDS	ENST00000407045	ENST00000302176	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
intron-3CDS	ENST00000407045	ENST00000506325	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
intron-3CDS	ENST00000464883	ENST00000296550	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
intron-3CDS	ENST00000464883	ENST00000302176	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
intron-3CDS	ENST00000464883	ENST00000506325	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
intron-intron	ENST00000378058	ENST00000507694	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
intron-intron	ENST00000402914	ENST00000507694	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
intron-intron	ENST00000407045	ENST00000507694	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+
intron-intron	ENST00000464883	ENST00000507694	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000217246	MACROD2	chr20	13983050	+	ENST00000296550	DCLK2	chr4	151023630	+	3648	558	341	2437	698
ENST00000217246	MACROD2	chr20	13983050	+	ENST00000506325	DCLK2	chr4	151023630	+	2435	558	341	2434	698
ENST00000217246	MACROD2	chr20	13983050	+	ENST00000302176	DCLK2	chr4	151023630	+	3680	558	341	2488	715
ENST00000310348	MACROD2	chr20	13983050	+	ENST00000296550	DCLK2	chr4	151023630	+	3253	163	0	2042	680
ENST00000310348	MACROD2	chr20	13983050	+	ENST00000506325	DCLK2	chr4	151023630	+	2040	163	0	2039	679
ENST00000310348	MACROD2	chr20	13983050	+	ENST00000302176	DCLK2	chr4	151023630	+	3285	163	0	2093	697

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000217246	ENST00000296550	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+	0.001801767	0.9981982
ENST00000217246	ENST00000506325	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+	0.001240203	0.99875987
ENST00000217246	ENST00000302176	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+	0.00200263	0.99799734
ENST00000310348	ENST00000296550	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+	0.001444894	0.9985551
ENST00000310348	ENST00000506325	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+	0.000770032	0.99923
ENST00000310348	ENST00000302176	MACROD2	chr20	13983050	+	DCLK2	chr4	151023630	+	0.001686718	0.9983133

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Fusion Genomic Features for MACROD2-DCLK2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MACROD2-DCLK2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:13983050/chr4:151023630)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000217246

6_9

426.0

Compositional bias

Note=Poly-Lys

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000310348

6_9

449.0

Compositional bias

Note=Poly-Lys

Tgene

DCLK2

chr20:13983050

chr4:151023630

ENST00000296550

293_362

140

767.0

Compositional bias

Note=Ser-rich

Tgene

DCLK2

chr20:13983050

chr4:151023630

ENST00000296550

713_753

140

767.0

Compositional bias

Note=Pro-rich

Tgene

DCLK2

chr20:13983050

chr4:151023630

ENST00000302176

293_362

140

784.0

Compositional bias

Note=Ser-rich

Tgene

DCLK2

chr20:13983050

chr4:151023630

ENST00000302176

713_753

140

784.0

Compositional bias

Note=Pro-rich

Tgene

DCLK2

chr20:13983050

chr4:151023630

ENST00000506325

293_362

140

766.0

Compositional bias

Note=Ser-rich

Tgene

DCLK2

chr20:13983050

chr4:151023630

ENST00000506325

713_753

140

766.0

Compositional bias

Note=Pro-rich

Tgene

DCLK2

chr20:13983050

chr4:151023630

ENST00000296550

197_280

140

767.0

Domain

Doublecortin 2

Tgene

DCLK2

chr20:13983050

chr4:151023630

ENST00000296550

394_651

140

767.0

Domain

Protein kinase

Tgene

DCLK2

chr20:13983050

chr4:151023630

ENST00000302176

197_280

140

784.0

Domain

Doublecortin 2

Tgene

DCLK2

chr20:13983050

chr4:151023630

ENST00000302176

394_651

140

784.0

Domain

Protein kinase

Tgene

DCLK2

chr20:13983050

chr4:151023630

ENST00000506325

197_280

140

766.0

Domain

Doublecortin 2

Tgene

DCLK2

chr20:13983050

chr4:151023630

ENST00000506325

394_651

140

766.0

Domain

Protein kinase

Tgene

DCLK2

chr20:13983050

chr4:151023630

ENST00000296550

400_408

140

767.0

Nucleotide binding

ATP

Tgene

DCLK2

chr20:13983050

chr4:151023630

ENST00000302176

400_408

140

784.0

Nucleotide binding

ATP

Tgene

DCLK2

chr20:13983050

chr4:151023630

ENST00000506325

400_408

140

766.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000217246

247_388

426.0

Compositional bias

Note=Glu-rich

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000310348

247_388

449.0

Compositional bias

Note=Glu-rich

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000378058

247_388

214.0

Compositional bias

Note=Glu-rich

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000378058

6_9

214.0

Compositional bias

Note=Poly-Lys

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000402914

247_388

214.0

Compositional bias

Note=Glu-rich

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000402914

6_9

214.0

Compositional bias

Note=Poly-Lys

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000407045

247_388

99.0

Compositional bias

Note=Glu-rich

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000407045

6_9

99.0

Compositional bias

Note=Poly-Lys

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000217246

59_240

426.0

Domain

Macro

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000310348

59_240

449.0

Domain

Macro

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000378058

59_240

214.0

Domain

Macro

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000402914

59_240

214.0

Domain

Macro

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000407045

59_240

99.0

Domain

Macro

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000217246

185_191

426.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000217246

77_79

426.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000217246

90_92

426.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000217246

97_102

426.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000310348

185_191

449.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000310348

77_79

449.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000310348

90_92

449.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000310348

97_102

449.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000378058

185_191

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000378058

77_79

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000378058

90_92

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000378058

97_102

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000402914

185_191

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000402914

77_79

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000402914

90_92

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000402914

97_102

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000407045

185_191

99.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000407045

77_79

99.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000407045

90_92

99.0

Region

Substrate binding

Hgene

MACROD2

chr20:13983050

chr4:151023630

ENST00000407045

97_102

99.0

Region

Substrate binding

Tgene

DCLK2

chr20:13983050

chr4:151023630

ENST00000296550

72_158

140

767.0

Domain

Doublecortin 1

Tgene

DCLK2

chr20:13983050

chr4:151023630

ENST00000302176

72_158

140

784.0

Domain

Doublecortin 1

Tgene

DCLK2

chr20:13983050

chr4:151023630

ENST00000506325

72_158

140

766.0

Domain

Doublecortin 1

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Fusion Gene Sequence for MACROD2-DCLK2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>50654_50654_1_MACROD2-DCLK2_MACROD2_chr20_13983050_ENST00000217246_DCLK2_chr4_151023630_ENST00000296550_length(transcript)=3648nt_BP=558nt
GCGTGCGCCCTGGGGCCCAAGTTGGGGCGCGCCGTGGCTAGAACACGGAGAGCGGCGGGCAGTGCAGCCAATGGGAGGCGGCGCTGCCTA
GCGGCTGGTAGGCGGTGCCTGCGCGGGTGTTAGGTTAGCGCGAGGCGTGACCTAGTTGACAGGCTCTGAGGTGCTGCTGTGGCGGCGTCC
GCGGGGCTGAGGCGGGTGGGAGCCGGAGCCGAGCGCGGGCTGAGGGAGGAGGGCGGCGACTGGAGAGCGGCGAGCGGCGAGCAGCGCAGG
ACGCAGAGCCTCTTTCACTTTTTCCCTGCTGAGTGCCCCCTCCCACCCCTCCCACTCCACACACACCCTGTTTGCCCGTGAGCCTGGGGA
ACTTGCAGCTTAAAGCCAGCCACCCCCACGGCAACATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTAT
TGAAGATGACCTTAGAAGAGAGACGCAAAGAATACCTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGG
GCAAGGGCCAAAATGATGGTGAGAGTTACGTGTGTGCATCCAATGAACCATTTCGTAAAGTCGATTACACCAAAAATATTAATCCAAACT
GGTCTGTGAACATCAAGGGTGGGACATCCCGAGCGCTGGCTGCTGCCTCCTCTGTGAAAAGTGAAGTAAAAGAAAGTAAAGATTTCATCA
AACCCAAGTTAGTGACTGTGATTCGAAGTGGAGTGAAGCCTAGAAAAGCCGTGCGGATCCTTCTGAATAAAAAGACTGCTCATTCCTTTG
AACAAGTCTTAACAGATATCACCGAAGCCATTAAACTAGACTCAGGAGTCGTCAAGAGGCTCTGCACCCTGGATGGAAAGCAGGTTACTT
GTCTGCAAGACTTTTTTGGTGATGACGATGTTTTTATTGCATGTGGACCAGAAAAATTTCGTTATGCCCAAGATGACTTTGTCCTGGATC
ATAGTGAATGTCGTGTCCTGAAGTCATCTTATTCTCGATCCTCAGCTGTTAAGTATTCTGGATCCAAAAGCCCTGGGCCCTCTCGACGCA
GCAAATCACCAGCTTCAGTTAATGGAACTCCCAGCAGCCAACTTTCTACTCCTAAATCTACGAAATCCTCCAGTTCCTCTCCAACTAGTC
CAGGAAGTTTCAGAGGATTAAAGCAGATTTCTGCTCATGGCAGATCTTCTTCCAATGTAAACGGTGGACCTGAGCTTGACCGTTGCATAA
GTCCTGAAGGTGTGAATGGAAACAGATGCTCTGAATCATCAACTCTTCTTGAGAAATACAAAATTGGAAAGGTCATTGGTGATGGCAATT
TTGCAGTAGTCAAAGAGTGTATAGACAGGTCCACTGGAAAGGAGTTTGCCCTAAAGATTATAGACAAAGCCAAATGTTGTGGAAAGGAAC
ACCTGATTGAGAATGAAGTGTCAATACTGCGCCGAGTGAAACATCCCAATATCATTATGCTGGTCGAGGAGATGGAAACAGCAACTGAGC
TCTTTCTGGTGATGGAATTGGTCAAAGGTGGAGATCTCTTTGATGCAATTACTTCGTCGACCAAGTACACTGAGAGAGATGGCAGTGCCA
TGGTGTACAACTTAGCCAATGCCCTCAGGTATCTCCATGGCCTCAGCATCGTGCACAGAGACATCAAACCAGAGAATCTCTTGGTGTGTG
AATATCCTGATGGAACCAAGTCTTTGAAACTGGGAGACTTTGGGCTTGCGACTGTGGTAGAAGGCCCTTTATACACAGTCTGTGGCACAC
CCACTTATGTGGCTCCAGAAATCATTGCTGAAACTGGCTATGGCCTGAAGGTGGACATTTGGGCAGCTGGTGTGATCACATACATACTTC
TCTGTGGATTCCCACCATTCCGAAGTGAGAACAATCTCCAGGAAGATCTCTTCGACCAGATCTTGGCTGGGAAGCTGGAGTTTCCGGCCC
CCTACTGGGATAACATCACGGACTCTGCCAAGGAATTAATCAGTCAAATGCTTCAGGTAAATGTTGAAGCTCGGTGTACCGCGGGACAAA
TCCTGAGTCACCCCTGGGTGTCAGATGATGCCTCCCAGGAGAATAACATGCAAGCTGAGGTGACAGGTAAACTAAAACAGCACTTTAATA
ATGCGCTCCCCAAACAGAACAGCACTACCACCGGGGTCTCCGTCATCATGAACACGGCTCTAGATAAGGAGGGGCAGATTTTCTGCAGCA
AGCACTGTCAAGACAGCGGCAGGCCTGGGATGGAGCCCATCTCTCCAGTTCCTCCCTCAGTGGAGGAGATCCCTGTGCCTGGGGAAGCAG
TCCCGGCCCCCACCCCTCCGGAATCTCCCACCCCCCACCCTCCTCCCGCTGCCCCGGGTGGTGAGCGGGCAGGAACCTGGCGCCGCCACC
GAGACTGAGCCTCCTGCAGACGGGCGAAGCCGCCTGCTGCAGCCCAGGAAGCCAGCCCTCTGCTCGGCCTCGCCGGCCTCCCTGCTGCAG
GCCTCCCTCTCTTCACCGCCTGCGCCTGAGTTCGCGGGTCCTCCGCAGGCCGCCTGGGAACCGGAGCCTGGCGTGCCGGAGCCTGGCCTG
GTGCTCTGGGCTCTGCCTTCTGGTTCCTGGAGGCATCAAAGGCTGCATCCGTTCTGCCAACAGCTGTTCGGAGAGACTCGTTCCAGATCA
TCCCGTCATTTTCAGTTTGTTGGACATTTTACAGCTTCACCAGGAGAATGTGCAACTTTATTCCAGCATTCGATGCATTTTTATAGAAAC
ACTTTGGAAACACTTTGGATGAACCAAGGCCTTTTCCTTATTTAAGTAGACTCAGAACACTCCCTTTCTTTTCTTTTCTCTCTCTCTCTC
TCTTTTTTTTTTACGAAAGACTTAGAATTGCATTTGTCCTTTTGTGGGTGTCCTGTGAGAGGTGATATGGGGGCTAAGAGGACTGGCTTT
CTAATAGAAGAAGTGAGCGCCTGAGAGGACAATTTGGTCATTGGACACGGATTGCAGGCTTTGAGAAGCGCTCAGAGGCCCAGGGCGGCG
GGCTCAGCCATTCGGCTTGGGGCACCAGGCTCCCCAGAGACAATGCTCAGTATTCATTCATACACAGACGATGGAAGAAGCCACTTCTTC
CCTGGGCGGTGTGGGTTTCCCCCAGCTCTTCCCACACGTGTGTTAGGAAATGCCCGTGAACTTGCCCTCTGGGCTTTTTAATGAGAGGCT
TGGCGCATGCGGCACCCAGCGGCTGCTTCCCTGCAAGCCAGCGACTTGCCGAGCAGAATGAGCTCTGCTCCTGAGCCCCGGTAGCTGCTT
CCTCATCTGCATTTCATCTGGAGCAGGGCAGGTAACCACAGGAGGAGGCATGCCCGAGGCAGCCAGGACTGGGCGGGAAGGTGCTCCCTG
GATATACTCTGTGAACCTTCTGGAAGGCTGCTGGCAGTTTTTCCTTTTTGTCCACCACCCTGCTCTTTTTAATAATTGTACATAATCCGT
GTATTTGTTTTACCTGCTCATCTTCTAAACTGGCGAGCCCTATAGTTCGTTCTCATTGTTAGATTTTGCCTTTTACAAGTGTCCCCAACC

>50654_50654_1_MACROD2-DCLK2_MACROD2_chr20_13983050_ENST00000217246_DCLK2_chr4_151023630_ENST00000296550_length(amino acids)=698AA_BP=72
MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDGESYVCASNEPFRKVDYT
KNINPNWSVNIKGGTSRALAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTL
DGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSS
SSSPTSPGSFRGLKQISAHGRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKA
KCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKP
ENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAG
KLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKE

--------------------------------------------------------------
>50654_50654_2_MACROD2-DCLK2_MACROD2_chr20_13983050_ENST00000217246_DCLK2_chr4_151023630_ENST00000302176_length(transcript)=3680nt_BP=558nt
GCGTGCGCCCTGGGGCCCAAGTTGGGGCGCGCCGTGGCTAGAACACGGAGAGCGGCGGGCAGTGCAGCCAATGGGAGGCGGCGCTGCCTA
GCGGCTGGTAGGCGGTGCCTGCGCGGGTGTTAGGTTAGCGCGAGGCGTGACCTAGTTGACAGGCTCTGAGGTGCTGCTGTGGCGGCGTCC
GCGGGGCTGAGGCGGGTGGGAGCCGGAGCCGAGCGCGGGCTGAGGGAGGAGGGCGGCGACTGGAGAGCGGCGAGCGGCGAGCAGCGCAGG
ACGCAGAGCCTCTTTCACTTTTTCCCTGCTGAGTGCCCCCTCCCACCCCTCCCACTCCACACACACCCTGTTTGCCCGTGAGCCTGGGGA
ACTTGCAGCTTAAAGCCAGCCACCCCCACGGCAACATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTAT
TGAAGATGACCTTAGAAGAGAGACGCAAAGAATACCTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGG
GCAAGGGCCAAAATGATGGTGAGAGTTACGTGTGTGCATCCAATGAACCATTTCGTAAAGTCGATTACACCAAAAATATTAATCCAAACT
GGTCTGTGAACATCAAGGGTGGGACATCCCGAGCGCTGGCTGCTGCCTCCTCTGTGAAAAGTGAAGTAAAAGAAAGTAAAGATTTCATCA
AACCCAAGTTAGTGACTGTGATTCGAAGTGGAGTGAAGCCTAGAAAAGCCGTGCGGATCCTTCTGAATAAAAAGACTGCTCATTCCTTTG
AACAAGTCTTAACAGATATCACCGAAGCCATTAAACTAGACTCAGGAGTCGTCAAGAGGCTCTGCACCCTGGATGGAAAGCAGGTTACTT
GTCTGCAAGACTTTTTTGGTGATGACGATGTTTTTATTGCATGTGGACCAGAAAAATTTCGTTATGCCCAAGATGACTTTGTCCTGGATC
ATAGTGAATGTCGTGTCCTGAAGTCATCTTATTCTCGATCCTCAGCTGTTAAGTATTCTGGATCCAAAAGCCCTGGGCCCTCTCGACGCA
GCAAATCACCAGCTTCAGTAAAGCGGGGTGGCCACTACTCCAGTGCCTATTCTACAGCCAAATCCCCAGTTAATGGAACTCCCAGCAGCC
AACTTTCTACTCCTAAATCTACGAAATCCTCCAGTTCCTCTCCAACTAGTCCAGGAAGTTTCAGAGGATTAAAGCAGATTTCTGCTCATG
GCAGATCTTCTTCCAATGTAAACGGTGGACCTGAGCTTGACCGTTGCATAAGTCCTGAAGGTGTGAATGGAAACAGATGCTCTGAATCAT
CAACTCTTCTTGAGAAATACAAAATTGGAAAGGTCATTGGTGATGGCAATTTTGCAGTAGTCAAAGAGTGTATAGACAGGTCCACTGGAA
AGGAGTTTGCCCTAAAGATTATAGACAAAGCCAAATGTTGTGGAAAGGAACACCTGATTGAGAATGAAGTGTCAATACTGCGCCGAGTGA
AACATCCCAATATCATTATGCTGGTCGAGGAGATGGAAACAGCAACTGAGCTCTTTCTGGTGATGGAATTGGTCAAAGGTGGAGATCTCT
TTGATGCAATTACTTCGTCGACCAAGTACACTGAGAGAGATGGCAGTGCCATGGTGTACAACTTAGCCAATGCCCTCAGGTATCTCCATG
GCCTCAGCATCGTGCACAGAGACATCAAACCAGAGAATCTCTTGGTGTGTGAATATCCTGATGGAACCAAGTCTTTGAAACTGGGAGACT
TTGGGCTTGCGACTGTGGTAGAAGGCCCTTTATACACAGTCTGTGGCACACCCACTTATGTGGCTCCAGAAATCATTGCTGAAACTGGCT
ATGGCCTGAAGGTGGACATTTGGGCAGCTGGTGTGATCACATACATACTTCTCTGTGGATTCCCACCATTCCGAAGTGAGAACAATCTCC
AGGAAGATCTCTTCGACCAGATCTTGGCTGGGAAGCTGGAGTTTCCGGCCCCCTACTGGGATAACATCACGGACTCTGCCAAGGAATTAA
TCAGTCAAATGCTTCAGGTAAATGTTGAAGCTCGGTGTACCGCGGGACAAATCCTGAGTCACCCCTGGGTGTCAGATGATGCCTCCCAGG
AGAATAACATGCAAGCTGAGGTGACAGGTAAACTAAAACAGCACTTTAATAATGCGCTCCCCAAACAGAACAGCACTACCACCGGGGTCT
CCGTCATCATGAACACGGCTCTAGATAAGGAGGGGCAGATTTTCTGCAGCAAGCACTGTCAAGACAGCGGCAGGCCTGGGATGGAGCCCA
TCTCTCCAGTTCCTCCCTCAGTGGAGGAGATCCCTGTGCCTGGGGAAGCAGTCCCGGCCCCCACCCCTCCGGAATCTCCCACCCCCCACC
CTCCTCCCGCTGCCCCGGGTGGTGAGCGGGCAGGAACCTGGCGCCGCCACCGAGACTGAGCCTCCTGCAGACGGGCGAAGCCGCCTGCTG
CAGCCCAGGAAGCCAGCCCTCTGCTCGGCCTCGCCGGCCTCCCTGCTGCAGGCCTCCCTCTCTTCACCGCCTGCGCCTGAGTTCGCGGGT
CCTCCGCAGGCCGCCTGGGAACCGGAGCCTGGCGTGCCGGAGCCTGGCCTGGTGCTCTGGGCTCTGCCTTCTGGTTCCTGGAGGCATCAA
AGGCTGCATCCGTTCTGCCAACAGCTGTTCGGAGAGACTCGTTCCAGATCATCCCGTCATTTTCAGTTTGTTGGACATTTTACAGCTTCA
CCAGGAGAATGTGCAACTTTATTCCAGCATTCGATGCATTTTTATAGAAACACTTTGGAAACACTTTGGATGAACCAAGGCCTTTTCCTT
ATTTAAGTAGACTCAGAACACTCCCTTTCTTTTCTTTTCTCTCTCTCTCTCTCTTTTTTTTTTACGAAAGACTTAGAATTGCATTTGTCC
TTTTGTGGGTGTCCTGTGAGAGGTGATATGGGGGCTAAGAGGACTGGCTTTCTAATAGAAGAAGTGAGCGCCTGAGAGGACAATTTGGTC
ATTGGACACGGATTGCAGGCTTTGAGAAGCGCTCAGAGGCCCAGGGCGGCGGGCTCAGCCATTCGGCTTGGGGCACCAGGCTCCCCAGAG
ACAATGCTCAGTATTCATTCATACACAGACGATGGAAGAAGCCACTTCTTCCCTGGGCGGTGTGGGTTTCCCCCAGCTCTTCCCACACGT
GTGTTAGGAAATGCCCGTGAACTTGCCCTCTGGGCTTTTTAATGAGAGGCTTGGCGCATGCGGCACCCAGCGGCTGCTTCCCTGCAAGCC
AGCGACTTGCCGAGCAGAATGAGCTCTGCTCCTGAGCCCCGGTAGCTGCTTCCTCATCTGCATTTCATCTGGAGCAGGGCAGGTAACCAC
AGGAGGAGGCATGCCCGAGGCAGCCAGGACTGGGCGGGAAGGTGCTCCCTGGATATACTCTGTGAACCTTCTGGAAGGCTGCTGGCAGTT
TTTCCTTTTTGTCCACCACCCTGCTCTTTTTAATAATTGTACATAATCCGTGTATTTGTTTTACCTGCTCATCTTCTAAACTGGCGAGCC

>50654_50654_2_MACROD2-DCLK2_MACROD2_chr20_13983050_ENST00000217246_DCLK2_chr4_151023630_ENST00000302176_length(amino acids)=715AA_BP=72
MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDGESYVCASNEPFRKVDYT
KNINPNWSVNIKGGTSRALAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTL
DGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVKRGGHYSSAYSTAKSPV
NGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAHGRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKEC
IDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLAN
ALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPF
RSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQN

--------------------------------------------------------------
>50654_50654_3_MACROD2-DCLK2_MACROD2_chr20_13983050_ENST00000217246_DCLK2_chr4_151023630_ENST00000506325_length(transcript)=2435nt_BP=558nt
GCGTGCGCCCTGGGGCCCAAGTTGGGGCGCGCCGTGGCTAGAACACGGAGAGCGGCGGGCAGTGCAGCCAATGGGAGGCGGCGCTGCCTA
GCGGCTGGTAGGCGGTGCCTGCGCGGGTGTTAGGTTAGCGCGAGGCGTGACCTAGTTGACAGGCTCTGAGGTGCTGCTGTGGCGGCGTCC
GCGGGGCTGAGGCGGGTGGGAGCCGGAGCCGAGCGCGGGCTGAGGGAGGAGGGCGGCGACTGGAGAGCGGCGAGCGGCGAGCAGCGCAGG
ACGCAGAGCCTCTTTCACTTTTTCCCTGCTGAGTGCCCCCTCCCACCCCTCCCACTCCACACACACCCTGTTTGCCCGTGAGCCTGGGGA
ACTTGCAGCTTAAAGCCAGCCACCCCCACGGCAACATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTAT
TGAAGATGACCTTAGAAGAGAGACGCAAAGAATACCTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGG
GCAAGGGCCAAAATGATGGTGAGAGTTACGTGTGTGCATCCAATGAACCATTTCGTAAAGTCGATTACACCAAAAATATTAATCCAAACT
GGTCTGTGAACATCAAGGGTGGGACATCCCGAGCGCTGGCTGCTGCCTCCTCTGTGAAAAGTGAAGTAAAAGAAAGTAAAGATTTCATCA
AACCCAAGTTAGTGACTGTGATTCGAAGTGGAGTGAAGCCTAGAAAAGCCGTGCGGATCCTTCTGAATAAAAAGACTGCTCATTCCTTTG
AACAAGTCTTAACAGATATCACCGAAGCCATTAAACTAGACTCAGGAGTCGTCAAGAGGCTCTGCACCCTGGATGGAAAGCAGGTTACTT
GTCTGCAAGACTTTTTTGGTGATGACGATGTTTTTATTGCATGTGGACCAGAAAAATTTCGTTATGCCCAAGATGACTTTGTCCTGGATC
ATAGTGAATGTCGTGTCCTGAAGTCATCTTATTCTCGATCCTCAGCTGTTAAGTATTCTGGATCCAAAAGCCCTGGGCCCTCTCGACGCA
GCAAATCACCAGCTTCAGTTAATGGAACTCCCAGCAGCCAACTTTCTACTCCTAAATCTACGAAATCCTCCAGTTCCTCTCCAACTAGTC
CAGGAAGTTTCAGAGGATTAAAGATTTCTGCTCATGGCAGATCTTCTTCCAATGTAAACGGTGGACCTGAGCTTGACCGTTGCATAAGTC
CTGAAGGTGTGAATGGAAACAGATGCTCTGAATCATCAACTCTTCTTGAGAAATACAAAATTGGAAAGGTCATTGGTGATGGCAATTTTG
CAGTAGTCAAAGAGTGTATAGACAGGTCCACTGGAAAGGAGTTTGCCCTAAAGATTATAGACAAAGCCAAATGTTGTGGAAAGGAACACC
TGATTGAGAATGAAGTGTCAATACTGCGCCGAGTGAAACATCCCAATATCATTATGCTGGTCGAGGAGATGGAAACAGCAACTGAGCTCT
TTCTGGTGATGGAATTGGTCAAAGGTGGAGATCTCTTTGATGCAATTACTTCGTCGACCAAGTACACTGAGAGAGATGGCAGTGCCATGG
TGTACAACTTAGCCAATGCCCTCAGGTATCTCCATGGCCTCAGCATCGTGCACAGAGACATCAAACCAGAGAATCTCTTGGTGTGTGAAT
ATCCTGATGGAACCAAGTCTTTGAAACTGGGAGACTTTGGGCTTGCGACTGTGGTAGAAGGCCCTTTATACACAGTCTGTGGCACACCCA
CTTATGTGGCTCCAGAAATCATTGCTGAAACTGGCTATGGCCTGAAGGTGGACATTTGGGCAGCTGGTGTGATCACATACATACTTCTCT
GTGGATTCCCACCATTCCGAAGTGAGAACAATCTCCAGGAAGATCTCTTCGACCAGATCTTGGCTGGGAAGCTGGAGTTTCCGGCCCCCT
ACTGGGATAACATCACGGACTCTGCCAAGGAATTAATCAGTCAAATGCTTCAGGTAAATGTTGAAGCTCGGTGTACCGCGGGACAAATCC
TGAGTCACCCCTGGGTGTCAGATGATGCCTCCCAGGAGAATAACATGCAAGCTGAGGTGACAGGTAAACTAAAACAGCACTTTAATAATG
CGCTCCCCAAACAGAACAGCACTACCACCGGGGTCTCCGTCATCATGAACACGGCTCTAGATAAGGAGGGGCAGATTTTCTGCAGCAAGC
ACTGTCAAGACAGCGGCAGGCCTGGGATGGAGCCCATCTCTCCAGTTCCTCCCTCAGTGGAGGAGATCCCTGTGCCTGGGGAAGCAGTCC
CGGCCCCCACCCCTCCGGAATCTCCCACCCCCCACCCTCCTCCCGCTGCCCCGGGTGGTGAGCGGGCAGGAACCTGGCGCCGCCACCGAG

>50654_50654_3_MACROD2-DCLK2_MACROD2_chr20_13983050_ENST00000217246_DCLK2_chr4_151023630_ENST00000506325_length(amino acids)=698AA_BP=72
MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDGESYVCASNEPFRKVDYT
KNINPNWSVNIKGGTSRALAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTL
DGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSS
SSSPTSPGSFRGLKISAHGRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAK
CCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPE
NLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGK
LEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEG

--------------------------------------------------------------
>50654_50654_4_MACROD2-DCLK2_MACROD2_chr20_13983050_ENST00000310348_DCLK2_chr4_151023630_ENST00000296550_length(transcript)=3253nt_BP=163nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGGTGAGAGTTACGTGTGT
GCATCCAATGAACCATTTCGTAAAGTCGATTACACCAAAAATATTAATCCAAACTGGTCTGTGAACATCAAGGGTGGGACATCCCGAGCG
CTGGCTGCTGCCTCCTCTGTGAAAAGTGAAGTAAAAGAAAGTAAAGATTTCATCAAACCCAAGTTAGTGACTGTGATTCGAAGTGGAGTG
AAGCCTAGAAAAGCCGTGCGGATCCTTCTGAATAAAAAGACTGCTCATTCCTTTGAACAAGTCTTAACAGATATCACCGAAGCCATTAAA
CTAGACTCAGGAGTCGTCAAGAGGCTCTGCACCCTGGATGGAAAGCAGGTTACTTGTCTGCAAGACTTTTTTGGTGATGACGATGTTTTT
ATTGCATGTGGACCAGAAAAATTTCGTTATGCCCAAGATGACTTTGTCCTGGATCATAGTGAATGTCGTGTCCTGAAGTCATCTTATTCT
CGATCCTCAGCTGTTAAGTATTCTGGATCCAAAAGCCCTGGGCCCTCTCGACGCAGCAAATCACCAGCTTCAGTTAATGGAACTCCCAGC
AGCCAACTTTCTACTCCTAAATCTACGAAATCCTCCAGTTCCTCTCCAACTAGTCCAGGAAGTTTCAGAGGATTAAAGCAGATTTCTGCT
CATGGCAGATCTTCTTCCAATGTAAACGGTGGACCTGAGCTTGACCGTTGCATAAGTCCTGAAGGTGTGAATGGAAACAGATGCTCTGAA
TCATCAACTCTTCTTGAGAAATACAAAATTGGAAAGGTCATTGGTGATGGCAATTTTGCAGTAGTCAAAGAGTGTATAGACAGGTCCACT
GGAAAGGAGTTTGCCCTAAAGATTATAGACAAAGCCAAATGTTGTGGAAAGGAACACCTGATTGAGAATGAAGTGTCAATACTGCGCCGA
GTGAAACATCCCAATATCATTATGCTGGTCGAGGAGATGGAAACAGCAACTGAGCTCTTTCTGGTGATGGAATTGGTCAAAGGTGGAGAT
CTCTTTGATGCAATTACTTCGTCGACCAAGTACACTGAGAGAGATGGCAGTGCCATGGTGTACAACTTAGCCAATGCCCTCAGGTATCTC
CATGGCCTCAGCATCGTGCACAGAGACATCAAACCAGAGAATCTCTTGGTGTGTGAATATCCTGATGGAACCAAGTCTTTGAAACTGGGA
GACTTTGGGCTTGCGACTGTGGTAGAAGGCCCTTTATACACAGTCTGTGGCACACCCACTTATGTGGCTCCAGAAATCATTGCTGAAACT
GGCTATGGCCTGAAGGTGGACATTTGGGCAGCTGGTGTGATCACATACATACTTCTCTGTGGATTCCCACCATTCCGAAGTGAGAACAAT
CTCCAGGAAGATCTCTTCGACCAGATCTTGGCTGGGAAGCTGGAGTTTCCGGCCCCCTACTGGGATAACATCACGGACTCTGCCAAGGAA
TTAATCAGTCAAATGCTTCAGGTAAATGTTGAAGCTCGGTGTACCGCGGGACAAATCCTGAGTCACCCCTGGGTGTCAGATGATGCCTCC
CAGGAGAATAACATGCAAGCTGAGGTGACAGGTAAACTAAAACAGCACTTTAATAATGCGCTCCCCAAACAGAACAGCACTACCACCGGG
GTCTCCGTCATCATGAACACGGCTCTAGATAAGGAGGGGCAGATTTTCTGCAGCAAGCACTGTCAAGACAGCGGCAGGCCTGGGATGGAG
CCCATCTCTCCAGTTCCTCCCTCAGTGGAGGAGATCCCTGTGCCTGGGGAAGCAGTCCCGGCCCCCACCCCTCCGGAATCTCCCACCCCC
CACCCTCCTCCCGCTGCCCCGGGTGGTGAGCGGGCAGGAACCTGGCGCCGCCACCGAGACTGAGCCTCCTGCAGACGGGCGAAGCCGCCT
GCTGCAGCCCAGGAAGCCAGCCCTCTGCTCGGCCTCGCCGGCCTCCCTGCTGCAGGCCTCCCTCTCTTCACCGCCTGCGCCTGAGTTCGC
GGGTCCTCCGCAGGCCGCCTGGGAACCGGAGCCTGGCGTGCCGGAGCCTGGCCTGGTGCTCTGGGCTCTGCCTTCTGGTTCCTGGAGGCA
TCAAAGGCTGCATCCGTTCTGCCAACAGCTGTTCGGAGAGACTCGTTCCAGATCATCCCGTCATTTTCAGTTTGTTGGACATTTTACAGC
TTCACCAGGAGAATGTGCAACTTTATTCCAGCATTCGATGCATTTTTATAGAAACACTTTGGAAACACTTTGGATGAACCAAGGCCTTTT
CCTTATTTAAGTAGACTCAGAACACTCCCTTTCTTTTCTTTTCTCTCTCTCTCTCTCTTTTTTTTTTACGAAAGACTTAGAATTGCATTT
GTCCTTTTGTGGGTGTCCTGTGAGAGGTGATATGGGGGCTAAGAGGACTGGCTTTCTAATAGAAGAAGTGAGCGCCTGAGAGGACAATTT
GGTCATTGGACACGGATTGCAGGCTTTGAGAAGCGCTCAGAGGCCCAGGGCGGCGGGCTCAGCCATTCGGCTTGGGGCACCAGGCTCCCC
AGAGACAATGCTCAGTATTCATTCATACACAGACGATGGAAGAAGCCACTTCTTCCCTGGGCGGTGTGGGTTTCCCCCAGCTCTTCCCAC
ACGTGTGTTAGGAAATGCCCGTGAACTTGCCCTCTGGGCTTTTTAATGAGAGGCTTGGCGCATGCGGCACCCAGCGGCTGCTTCCCTGCA
AGCCAGCGACTTGCCGAGCAGAATGAGCTCTGCTCCTGAGCCCCGGTAGCTGCTTCCTCATCTGCATTTCATCTGGAGCAGGGCAGGTAA
CCACAGGAGGAGGCATGCCCGAGGCAGCCAGGACTGGGCGGGAAGGTGCTCCCTGGATATACTCTGTGAACCTTCTGGAAGGCTGCTGGC
AGTTTTTCCTTTTTGTCCACCACCCTGCTCTTTTTAATAATTGTACATAATCCGTGTATTTGTTTTACCTGCTCATCTTCTAAACTGGCG
AGCCCTATAGTTCGTTCTCATTGTTAGATTTTGCCTTTTACAAGTGTCCCCAACCTGCAATAAACTTTTCCCTCTTGAAAAAAAGTAATC

>50654_50654_4_MACROD2-DCLK2_MACROD2_chr20_13983050_ENST00000310348_DCLK2_chr4_151023630_ENST00000296550_length(amino acids)=680AA_BP=54
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRA
LAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDFFGDDDVF
IACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISA
HGRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRR
VKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLG
DFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKE
LISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPGME

--------------------------------------------------------------
>50654_50654_5_MACROD2-DCLK2_MACROD2_chr20_13983050_ENST00000310348_DCLK2_chr4_151023630_ENST00000302176_length(transcript)=3285nt_BP=163nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGGTGAGAGTTACGTGTGT
GCATCCAATGAACCATTTCGTAAAGTCGATTACACCAAAAATATTAATCCAAACTGGTCTGTGAACATCAAGGGTGGGACATCCCGAGCG
CTGGCTGCTGCCTCCTCTGTGAAAAGTGAAGTAAAAGAAAGTAAAGATTTCATCAAACCCAAGTTAGTGACTGTGATTCGAAGTGGAGTG
AAGCCTAGAAAAGCCGTGCGGATCCTTCTGAATAAAAAGACTGCTCATTCCTTTGAACAAGTCTTAACAGATATCACCGAAGCCATTAAA
CTAGACTCAGGAGTCGTCAAGAGGCTCTGCACCCTGGATGGAAAGCAGGTTACTTGTCTGCAAGACTTTTTTGGTGATGACGATGTTTTT
ATTGCATGTGGACCAGAAAAATTTCGTTATGCCCAAGATGACTTTGTCCTGGATCATAGTGAATGTCGTGTCCTGAAGTCATCTTATTCT
CGATCCTCAGCTGTTAAGTATTCTGGATCCAAAAGCCCTGGGCCCTCTCGACGCAGCAAATCACCAGCTTCAGTAAAGCGGGGTGGCCAC
TACTCCAGTGCCTATTCTACAGCCAAATCCCCAGTTAATGGAACTCCCAGCAGCCAACTTTCTACTCCTAAATCTACGAAATCCTCCAGT
TCCTCTCCAACTAGTCCAGGAAGTTTCAGAGGATTAAAGCAGATTTCTGCTCATGGCAGATCTTCTTCCAATGTAAACGGTGGACCTGAG
CTTGACCGTTGCATAAGTCCTGAAGGTGTGAATGGAAACAGATGCTCTGAATCATCAACTCTTCTTGAGAAATACAAAATTGGAAAGGTC
ATTGGTGATGGCAATTTTGCAGTAGTCAAAGAGTGTATAGACAGGTCCACTGGAAAGGAGTTTGCCCTAAAGATTATAGACAAAGCCAAA
TGTTGTGGAAAGGAACACCTGATTGAGAATGAAGTGTCAATACTGCGCCGAGTGAAACATCCCAATATCATTATGCTGGTCGAGGAGATG
GAAACAGCAACTGAGCTCTTTCTGGTGATGGAATTGGTCAAAGGTGGAGATCTCTTTGATGCAATTACTTCGTCGACCAAGTACACTGAG
AGAGATGGCAGTGCCATGGTGTACAACTTAGCCAATGCCCTCAGGTATCTCCATGGCCTCAGCATCGTGCACAGAGACATCAAACCAGAG
AATCTCTTGGTGTGTGAATATCCTGATGGAACCAAGTCTTTGAAACTGGGAGACTTTGGGCTTGCGACTGTGGTAGAAGGCCCTTTATAC
ACAGTCTGTGGCACACCCACTTATGTGGCTCCAGAAATCATTGCTGAAACTGGCTATGGCCTGAAGGTGGACATTTGGGCAGCTGGTGTG
ATCACATACATACTTCTCTGTGGATTCCCACCATTCCGAAGTGAGAACAATCTCCAGGAAGATCTCTTCGACCAGATCTTGGCTGGGAAG
CTGGAGTTTCCGGCCCCCTACTGGGATAACATCACGGACTCTGCCAAGGAATTAATCAGTCAAATGCTTCAGGTAAATGTTGAAGCTCGG
TGTACCGCGGGACAAATCCTGAGTCACCCCTGGGTGTCAGATGATGCCTCCCAGGAGAATAACATGCAAGCTGAGGTGACAGGTAAACTA
AAACAGCACTTTAATAATGCGCTCCCCAAACAGAACAGCACTACCACCGGGGTCTCCGTCATCATGAACACGGCTCTAGATAAGGAGGGG
CAGATTTTCTGCAGCAAGCACTGTCAAGACAGCGGCAGGCCTGGGATGGAGCCCATCTCTCCAGTTCCTCCCTCAGTGGAGGAGATCCCT
GTGCCTGGGGAAGCAGTCCCGGCCCCCACCCCTCCGGAATCTCCCACCCCCCACCCTCCTCCCGCTGCCCCGGGTGGTGAGCGGGCAGGA
ACCTGGCGCCGCCACCGAGACTGAGCCTCCTGCAGACGGGCGAAGCCGCCTGCTGCAGCCCAGGAAGCCAGCCCTCTGCTCGGCCTCGCC
GGCCTCCCTGCTGCAGGCCTCCCTCTCTTCACCGCCTGCGCCTGAGTTCGCGGGTCCTCCGCAGGCCGCCTGGGAACCGGAGCCTGGCGT
GCCGGAGCCTGGCCTGGTGCTCTGGGCTCTGCCTTCTGGTTCCTGGAGGCATCAAAGGCTGCATCCGTTCTGCCAACAGCTGTTCGGAGA
GACTCGTTCCAGATCATCCCGTCATTTTCAGTTTGTTGGACATTTTACAGCTTCACCAGGAGAATGTGCAACTTTATTCCAGCATTCGAT
GCATTTTTATAGAAACACTTTGGAAACACTTTGGATGAACCAAGGCCTTTTCCTTATTTAAGTAGACTCAGAACACTCCCTTTCTTTTCT
TTTCTCTCTCTCTCTCTCTTTTTTTTTTACGAAAGACTTAGAATTGCATTTGTCCTTTTGTGGGTGTCCTGTGAGAGGTGATATGGGGGC
TAAGAGGACTGGCTTTCTAATAGAAGAAGTGAGCGCCTGAGAGGACAATTTGGTCATTGGACACGGATTGCAGGCTTTGAGAAGCGCTCA
GAGGCCCAGGGCGGCGGGCTCAGCCATTCGGCTTGGGGCACCAGGCTCCCCAGAGACAATGCTCAGTATTCATTCATACACAGACGATGG
AAGAAGCCACTTCTTCCCTGGGCGGTGTGGGTTTCCCCCAGCTCTTCCCACACGTGTGTTAGGAAATGCCCGTGAACTTGCCCTCTGGGC
TTTTTAATGAGAGGCTTGGCGCATGCGGCACCCAGCGGCTGCTTCCCTGCAAGCCAGCGACTTGCCGAGCAGAATGAGCTCTGCTCCTGA
GCCCCGGTAGCTGCTTCCTCATCTGCATTTCATCTGGAGCAGGGCAGGTAACCACAGGAGGAGGCATGCCCGAGGCAGCCAGGACTGGGC
GGGAAGGTGCTCCCTGGATATACTCTGTGAACCTTCTGGAAGGCTGCTGGCAGTTTTTCCTTTTTGTCCACCACCCTGCTCTTTTTAATA
ATTGTACATAATCCGTGTATTTGTTTTACCTGCTCATCTTCTAAACTGGCGAGCCCTATAGTTCGTTCTCATTGTTAGATTTTGCCTTTT

>50654_50654_5_MACROD2-DCLK2_MACROD2_chr20_13983050_ENST00000310348_DCLK2_chr4_151023630_ENST00000302176_length(amino acids)=697AA_BP=54
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRA
LAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDFFGDDDVF
IACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVKRGGHYSSAYSTAKSPVNGTPSSQLSTPKSTKSSS
SSPTSPGSFRGLKQISAHGRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAK
CCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPE
NLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGK
LEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEG

--------------------------------------------------------------
>50654_50654_6_MACROD2-DCLK2_MACROD2_chr20_13983050_ENST00000310348_DCLK2_chr4_151023630_ENST00000506325_length(transcript)=2040nt_BP=163nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGGTGAGAGTTACGTGTGT
GCATCCAATGAACCATTTCGTAAAGTCGATTACACCAAAAATATTAATCCAAACTGGTCTGTGAACATCAAGGGTGGGACATCCCGAGCG
CTGGCTGCTGCCTCCTCTGTGAAAAGTGAAGTAAAAGAAAGTAAAGATTTCATCAAACCCAAGTTAGTGACTGTGATTCGAAGTGGAGTG
AAGCCTAGAAAAGCCGTGCGGATCCTTCTGAATAAAAAGACTGCTCATTCCTTTGAACAAGTCTTAACAGATATCACCGAAGCCATTAAA
CTAGACTCAGGAGTCGTCAAGAGGCTCTGCACCCTGGATGGAAAGCAGGTTACTTGTCTGCAAGACTTTTTTGGTGATGACGATGTTTTT
ATTGCATGTGGACCAGAAAAATTTCGTTATGCCCAAGATGACTTTGTCCTGGATCATAGTGAATGTCGTGTCCTGAAGTCATCTTATTCT
CGATCCTCAGCTGTTAAGTATTCTGGATCCAAAAGCCCTGGGCCCTCTCGACGCAGCAAATCACCAGCTTCAGTTAATGGAACTCCCAGC
AGCCAACTTTCTACTCCTAAATCTACGAAATCCTCCAGTTCCTCTCCAACTAGTCCAGGAAGTTTCAGAGGATTAAAGATTTCTGCTCAT
GGCAGATCTTCTTCCAATGTAAACGGTGGACCTGAGCTTGACCGTTGCATAAGTCCTGAAGGTGTGAATGGAAACAGATGCTCTGAATCA
TCAACTCTTCTTGAGAAATACAAAATTGGAAAGGTCATTGGTGATGGCAATTTTGCAGTAGTCAAAGAGTGTATAGACAGGTCCACTGGA
AAGGAGTTTGCCCTAAAGATTATAGACAAAGCCAAATGTTGTGGAAAGGAACACCTGATTGAGAATGAAGTGTCAATACTGCGCCGAGTG
AAACATCCCAATATCATTATGCTGGTCGAGGAGATGGAAACAGCAACTGAGCTCTTTCTGGTGATGGAATTGGTCAAAGGTGGAGATCTC
TTTGATGCAATTACTTCGTCGACCAAGTACACTGAGAGAGATGGCAGTGCCATGGTGTACAACTTAGCCAATGCCCTCAGGTATCTCCAT
GGCCTCAGCATCGTGCACAGAGACATCAAACCAGAGAATCTCTTGGTGTGTGAATATCCTGATGGAACCAAGTCTTTGAAACTGGGAGAC
TTTGGGCTTGCGACTGTGGTAGAAGGCCCTTTATACACAGTCTGTGGCACACCCACTTATGTGGCTCCAGAAATCATTGCTGAAACTGGC
TATGGCCTGAAGGTGGACATTTGGGCAGCTGGTGTGATCACATACATACTTCTCTGTGGATTCCCACCATTCCGAAGTGAGAACAATCTC
CAGGAAGATCTCTTCGACCAGATCTTGGCTGGGAAGCTGGAGTTTCCGGCCCCCTACTGGGATAACATCACGGACTCTGCCAAGGAATTA
ATCAGTCAAATGCTTCAGGTAAATGTTGAAGCTCGGTGTACCGCGGGACAAATCCTGAGTCACCCCTGGGTGTCAGATGATGCCTCCCAG
GAGAATAACATGCAAGCTGAGGTGACAGGTAAACTAAAACAGCACTTTAATAATGCGCTCCCCAAACAGAACAGCACTACCACCGGGGTC
TCCGTCATCATGAACACGGCTCTAGATAAGGAGGGGCAGATTTTCTGCAGCAAGCACTGTCAAGACAGCGGCAGGCCTGGGATGGAGCCC
ATCTCTCCAGTTCCTCCCTCAGTGGAGGAGATCCCTGTGCCTGGGGAAGCAGTCCCGGCCCCCACCCCTCCGGAATCTCCCACCCCCCAC

>50654_50654_6_MACROD2-DCLK2_MACROD2_chr20_13983050_ENST00000310348_DCLK2_chr4_151023630_ENST00000506325_length(amino acids)=679AA_BP=54
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRA
LAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDFFGDDDVF
IACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKISAH
GRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRV
KHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGD
FGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL
ISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPGMEP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MACROD2-DCLK2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MACROD2-DCLK2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MACROD2-DCLK2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	MACROD2	C0004352	Autistic Disorder	1	CTD_human
Hgene	MACROD2	C0013146	Drug abuse	1	CTD_human
Hgene	MACROD2	C0013170	Drug habituation	1	CTD_human
Hgene	MACROD2	C0013222	Drug Use Disorders	1	CTD_human
Hgene	MACROD2	C0023903	Liver neoplasms	1	CTD_human
Hgene	MACROD2	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Hgene	MACROD2	C0038580	Substance Dependence	1	CTD_human
Hgene	MACROD2	C0038586	Substance Use Disorders	1	CTD_human
Hgene	MACROD2	C0236969	Substance-Related Disorders	1	CTD_human
Hgene	MACROD2	C0345904	Malignant neoplasm of liver	1	CTD_human
Hgene	MACROD2	C0740858	Substance abuse problem	1	CTD_human
Hgene	MACROD2	C1510472	Drug Dependence	1	CTD_human
Hgene	MACROD2	C4316881	Prescription Drug Abuse	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:MACROD2-DCLK2 (FusionGDB2 ID:HG140733TG166614)

Fusion Gene Summary for MACROD2-DCLK2

Fusion Gene ORF analysis for MACROD2-DCLK2

Fusion Genomic Features for MACROD2-DCLK2

Fusion Protein Features for MACROD2-DCLK2

Fusion Gene Sequence for MACROD2-DCLK2

Fusion Gene PPI Analysis for MACROD2-DCLK2

Related Drugs for MACROD2-DCLK2

Related Diseases for MACROD2-DCLK2

Fusion Gene Studies
in Kim Lab