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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CTNND2-POLR1A (FusionGDB2 ID:HG1501TG25885)

Fusion Gene Summary for CTNND2-POLR1A

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNND2-POLR1A
Fusion gene ID: hg1501tg25885
HgeneTgene
Gene symbol

CTNND2

POLR1A

Gene ID

1501

25885

Gene namecatenin delta 2RNA polymerase I subunit A
SynonymsGT24|NPRAPA190|AFDCIN|RPA1|RPA194|RPO1-4|RPO14
Cytomap('CTNND2')('POLR1A')

5p15.2

2p11.2

Type of geneprotein-codingprotein-coding
Descriptioncatenin delta-2T-cell delta-catenincatenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)neurojunginDNA-directed RNA polymerase I subunit RPA1DNA-directed RNA polymerase I largest subunitDNA-directed RNA polymerase I subunit ADNA-directed RNA polymerase I subunit A1RNA polymerase I 194 kDa subunitpolymerase (RNA) I polypeptide A, 194kDapolymerase
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000304623, ENST00000359640, 
ENST00000458100, ENST00000495388, 
ENST00000503622, ENST00000511377, 
Fusion gene scores* DoF score14 X 13 X 7=12744 X 5 X 4=80
# samples 155
** MAII scorelog2(15/1274*10)=-3.08633087176042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTNND2 [Title/Abstract] AND POLR1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTNND2(11732248)-POLR1A(86257519), # samples:1
Anticipated loss of major functional domain due to fusion event.CTNND2-POLR1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CTNND2-POLR1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CTNND2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across POLR1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D3-A2JC-06ACTNND2chr5

11732248

-POLR1Achr2

86257519

-


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Fusion Gene ORF analysis for CTNND2-POLR1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000304623ENST00000483538CTNND2chr5

11732248

-POLR1Achr2

86257519

-
5CDS-intronENST00000359640ENST00000483538CTNND2chr5

11732248

-POLR1Achr2

86257519

-
5UTR-3CDSENST00000458100ENST00000263857CTNND2chr5

11732248

-POLR1Achr2

86257519

-
5UTR-3CDSENST00000458100ENST00000409681CTNND2chr5

11732248

-POLR1Achr2

86257519

-
5UTR-intronENST00000458100ENST00000483538CTNND2chr5

11732248

-POLR1Achr2

86257519

-
In-frameENST00000304623ENST00000263857CTNND2chr5

11732248

-POLR1Achr2

86257519

-
In-frameENST00000304623ENST00000409681CTNND2chr5

11732248

-POLR1Achr2

86257519

-
In-frameENST00000359640ENST00000263857CTNND2chr5

11732248

-POLR1Achr2

86257519

-
In-frameENST00000359640ENST00000409681CTNND2chr5

11732248

-POLR1Achr2

86257519

-
intron-3CDSENST00000495388ENST00000263857CTNND2chr5

11732248

-POLR1Achr2

86257519

-
intron-3CDSENST00000495388ENST00000409681CTNND2chr5

11732248

-POLR1Achr2

86257519

-
intron-3CDSENST00000503622ENST00000263857CTNND2chr5

11732248

-POLR1Achr2

86257519

-
intron-3CDSENST00000503622ENST00000409681CTNND2chr5

11732248

-POLR1Achr2

86257519

-
intron-3CDSENST00000511377ENST00000263857CTNND2chr5

11732248

-POLR1Achr2

86257519

-
intron-3CDSENST00000511377ENST00000409681CTNND2chr5

11732248

-POLR1Achr2

86257519

-
intron-intronENST00000495388ENST00000483538CTNND2chr5

11732248

-POLR1Achr2

86257519

-
intron-intronENST00000503622ENST00000483538CTNND2chr5

11732248

-POLR1Achr2

86257519

-
intron-intronENST00000511377ENST00000483538CTNND2chr5

11732248

-POLR1Achr2

86257519

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000304623CTNND2chr511732248-ENST00000263857POLR1Achr286257519-8156364190948252
ENST00000304623CTNND2chr511732248-ENST00000409681POLR1Achr286257519-2044364190948252
ENST00000359640CTNND2chr511732248-ENST00000263857POLR1Achr286257519-8111319145903252
ENST00000359640CTNND2chr511732248-ENST00000409681POLR1Achr286257519-1999319145903252

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000304623ENST00000263857CTNND2chr511732248-POLR1Achr286257519-0.0037339510.99626607
ENST00000304623ENST00000409681CTNND2chr511732248-POLR1Achr286257519-0.0058409990.994159
ENST00000359640ENST00000263857CTNND2chr511732248-POLR1Achr286257519-0.0036726150.99632734
ENST00000359640ENST00000409681CTNND2chr511732248-POLR1Achr286257519-0.0060983910.9939016

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Fusion Genomic Features for CTNND2-POLR1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CTNND2-POLR1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:11732248/chr2:86257519)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCTNND2chr5:11732248chr2:86257519ENST00000304623-22249_84581226.0Coiled coilOntology_term=ECO:0000255
HgeneCTNND2chr5:11732248chr2:86257519ENST00000359640-22149_84581168.0Coiled coilOntology_term=ECO:0000255
HgeneCTNND2chr5:11732248chr2:86257519ENST00000304623-222216_226581226.0Compositional biasNote=Poly-Pro
HgeneCTNND2chr5:11732248chr2:86257519ENST00000304623-222811_817581226.0Compositional biasNote=Poly-Lys
HgeneCTNND2chr5:11732248chr2:86257519ENST00000359640-221216_226581168.0Compositional biasNote=Poly-Pro
HgeneCTNND2chr5:11732248chr2:86257519ENST00000359640-221811_817581168.0Compositional biasNote=Poly-Lys
HgeneCTNND2chr5:11732248chr2:86257519ENST00000304623-222394_438581226.0RepeatNote=ARM 1
HgeneCTNND2chr5:11732248chr2:86257519ENST00000304623-222540_579581226.0RepeatNote=ARM 2
HgeneCTNND2chr5:11732248chr2:86257519ENST00000304623-222582_621581226.0RepeatNote=ARM 3
HgeneCTNND2chr5:11732248chr2:86257519ENST00000304623-222626_666581226.0RepeatNote=ARM 4
HgeneCTNND2chr5:11732248chr2:86257519ENST00000304623-222682_724581226.0RepeatNote=ARM 5
HgeneCTNND2chr5:11732248chr2:86257519ENST00000304623-222728_773581226.0RepeatNote=ARM 6
HgeneCTNND2chr5:11732248chr2:86257519ENST00000304623-222835_875581226.0RepeatNote=ARM 7
HgeneCTNND2chr5:11732248chr2:86257519ENST00000304623-222882_921581226.0RepeatNote=ARM 8
HgeneCTNND2chr5:11732248chr2:86257519ENST00000304623-222975_1018581226.0RepeatNote=ARM 9
HgeneCTNND2chr5:11732248chr2:86257519ENST00000359640-221394_438581168.0RepeatNote=ARM 1
HgeneCTNND2chr5:11732248chr2:86257519ENST00000359640-221540_579581168.0RepeatNote=ARM 2
HgeneCTNND2chr5:11732248chr2:86257519ENST00000359640-221582_621581168.0RepeatNote=ARM 3
HgeneCTNND2chr5:11732248chr2:86257519ENST00000359640-221626_666581168.0RepeatNote=ARM 4
HgeneCTNND2chr5:11732248chr2:86257519ENST00000359640-221682_724581168.0RepeatNote=ARM 5
HgeneCTNND2chr5:11732248chr2:86257519ENST00000359640-221728_773581168.0RepeatNote=ARM 6
HgeneCTNND2chr5:11732248chr2:86257519ENST00000359640-221835_875581168.0RepeatNote=ARM 7
HgeneCTNND2chr5:11732248chr2:86257519ENST00000359640-221882_921581168.0RepeatNote=ARM 8
HgeneCTNND2chr5:11732248chr2:86257519ENST00000359640-221975_1018581168.0RepeatNote=ARM 9
TgenePOLR1Achr5:11732248chr2:86257519ENST000002638572934961_97315261721.0RegionBridging helix


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Fusion Gene Sequence for CTNND2-POLR1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>20398_20398_1_CTNND2-POLR1A_CTNND2_chr5_11732248_ENST00000304623_POLR1A_chr2_86257519_ENST00000263857_length(transcript)=8156nt_BP=364nt
GCGTCGGGAGCCGCCTCTCGCCCGCGGCGCTCGCCCCTGCCGCCCGCCAGCATCCCTTGTCCCGCGGCCGCGCTCAGACAACAAAAGCGG
AAGATGCTGCAGTTGGGCAAGGTCAGGACCTTGCCCTGAAGCCGGGCGGCGCCGCGCACGCCTCTTCCCGGACTGAGGAGCTGTCGCCGG
CGGAGGGTGCATGTTTGCGAGGAAGCCGCCGGGCGCCGCGCCTTTGGGAGCTATGCCTGTTCCAGACCAGCCTTCATCAGCCTCAGAGAA
GACGAGTTCCCTGAGCCCCGGCTTAAACACCTCCAACGGGGATGGCTCTGAAACAGAAACCACCTCTGCCATCCTCGCCTCAGTCAAAGA
ACAGGTGACAGTGAAGCTCCCTCTGATGAAGATCAACTTTGACATGAGCTCCCTGGTAGTATCTTTGGCCCATGGTGCCGTCATCTATGC
GACCAAGGGCATCACTCGGTGCCTCCTGAATGAAACAACCAACAATAAGAACGAGAAGGAGCTTGTGCTAAACACAGAAGGAATCAACCT
CCCAGAGCTATTCAAGTATGCAGAGGTCCTGGATCTGCGCCGCCTCTACTCCAACGACATCCACGCCATAGCCAACACGTATGGCATTGA
GGCCGCGCTGCGGGTGATCGAGAAGGAGATCAAGGATGTGTTTGCCGTGTATGGCATCGCGGTCGACCCTCGCCATCTCTCCCTGGTTGC
TGATTATATGTGCTTCGAGGGTGTTTACAAGCCACTGAATCGCTTTGGGATCCGGTCAAACTCTTCCCCGCTACAGCAGATGACATTTGA
AACCAGCTTCCAGTTTCTGAAGCAAGCCACCATGCTGGGATCCCACGATGAGCTGAGGTCTCCTTCTGCCTGCCTTGTGGTCGGGAAGGT
CGTCAGGGGCGGGACAGGCCTGTTCGAGCTCAAGCAGCCTCTGAGATAGCAGCTACCCCGGCACCATCTGCCCAGCTCCAAGGACCCTTG
GTGAGGGCGTGGCCCAGCCTGCCTTCTGCATGAGAGGACCAGGAGACTGGAATCCAGGGCAGTTCCAAGTGACAGTACAGAGCACAGCAG
CGACCTTGGGCCTGAAAGCAGTGGGCCTCTGAGCTGGGCCAGCTTCACCTGGAAAGTGACAGAGTTGCTCATCCTTGCCCCTCCCTGTCT
CTGGATTTTTATCAAGGTTTACCAAGTCTTCTGAGTCCCCCTGAGATGGCTGGGGCCTCACCTGTGCTGCAGGAGGCCTCTGTGGCATAA
CCCCTAAGGAGAAGTCCTGATTCACGATTCACTGAGAAGACCAAGGGGAAGCCATGCTTTGCTGCTGGGGACCCCAGGCACCTCCAGAGT
AGGGAAGCGGGGTTCTTTTGCTGTGAGTGGCCAGGGACAACAGACAAGATTCCTGGGGGCTCCCGATGAGCAGGAACGTGGAGCCTGCTG
CCCAAGGCCTGCTCCTTCCGGCTGCTCCAGCCCCTGGGGGCAGAGTCCACAAAGAGTCCCCATCAAGACTTCTTCCCTGAGTCAAGTACA
GCGTAGCATAGTCCTCCACCCACCCAACCTCTCTGCCTGGCCAGGGTCCTGGCCCTGCCACTGTGTGGCGAGGTGTCCTTCTAGACCACA
TCAGCCCCAAGGCTGGGAGCAGTCGCTCCAGGGCCGCAGCAGTTCACTCCCACACATAGAACCCAGGTCACTGCTGGGGCGATTGAACAG
GTTGCCTGGCTTTTCTCTGCTGTCAGTTTGGTGTGGAGGCCTATGTTCTGCCCCATACACCCCACAGGCCCTGCTTATGGGAAGGAACAC
AGGCCTCCAGCCCAGAGGACTGTGCCGCCCTGTTCTTGGCCGTCCACGTTTCCTCTCCCTCTAGCACCAGCAATACATTTCCCTGGCATG
GACAGAAAAGACAGAGAGGACTTATACAAAGGCTTTGTAAAACCAGAGGCTAGCTTCTATCTTTGTCTACTGTTATTTCAGCTCAGGGCG
GGTAATTAACATCATTGGAACTAGCTATTAGGAAAGAAAAAAAACTTGGTTTTTTTTACAACAATTTTTTCCCTTGGTTTGCAGTTTCTG
CATTTGGATTTGAGAACCCAGGGCGGGGATTTTCTTGGCACAGTCAGGTCTTGGGTCCCTCTTCCTGTGCTTTCTTGTCTGAGGCCTTAG
GGGGAAGAGCTCAGCCTCTGCAGCCTCCTCCACCTCTGCCCCTGGCCTGCCTCTGCTGTGACCTCCTTCCAGAGCTAGCTGCTGGCCCTG
TGGCCAGGAGAAGCAGAGGGGAGAAGCCTTTATGCAGAAGCTGTGCTAGCCTTGGTCTGGGGTGGGGAGGCTGCTGCTGTGACCTTAGGG
GTAGGGTTGGGGATCAAGGGAGGCTTTGTCAAGGGAGAGTGACCATGTTGCTCCCTACATCCATGCAATAGGACCCAGCCTGCACCTCCT
AGGCCTACACTGGGGAAAGCCTGACAGAAATCAGTACCTCCTAACGGGGTCTGCCAGGTTCACCAAGGCATGGGCACAGAGGAATATGAC
AGTTTTGAGGCAGGCAGGAAGGGCCCAGCCTGCAGGGTAAGACATTCATTCTTTGAGTTAAAGGCCATATTCACTTGATGATTTCTACAC
ACACTAGAATTGTGAGAGTGTCCTTGAAGGAGATCACAAAGTAACCTGGTGACTGTGGCACAGGGTCCGTGGATTCCATCTCTCCCAGGC
ACTGAGGGCGCAGAGGCGAAGGAGCAAGCCCTGCATATTGGCAGGGCTGTGACCATCGCACTTAGATCAGACCCCCGACCTGTGTTGGGA
TGTGAGGGATGCCCTCCTGCCCCACCCATCCACATGGTTCCTGGGCAGCTCTGTTTTATTCCTGTGTCTTTCCTGATGGATGAGTATTAA
GACAGCATGTCTGGTTTTTAAACAGACATTTGGGAGCTTGCACATCCTGATGAGCAGGGACTCACTGTGGTGGCCTTAGGGAATTACACG
CTCACTTTGGTGGTTCTCTATGCTCGGAAGCCTCTGAGAGTGGCCTTGGCAGCTTAAGATGGCAGAGGCTTTGGAGTCTTCTTAGGACTG
TAAGTGCCCATTGAGGATGCATTTGAGTTTTGGAAAGTAGGCCCAAGTCAAATCTGATGGATGGATTCAAGAACATGGACTAATCTGCGT
TGTCATTTTTAATCAAAATGTAATGGAGATTGATCATCTGGTGGGGTTCACAAACTTTTCATGAGAGCTGTGAGTTCTTTTTTTGAGATG
CACTTTTGCACTTGTTACCCAGGCTGAGTGCAATGGCGCAATCTCGGCTCCACTGCAACCTCCATCTCCCGAGTTCAAGCGATTCTCCTG
CCTCAGCCTCCCGAGTAGCTGAGATTACAGGCATGCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATG
TTGGCCAGGCTAGTCTCGAACTCCTAATCTCAGGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGTTTACAGGCGTGAGCTACTGTG
CCGGCCAGAGCTATGAGTTCTTTCAGAATCCTCAGATGCCATTAGCTAGCCACTGTTTGGACATCCTTCTCACCTTGCCCTTTGGGGTGA
TATCCATACCTACTTGCTTGCTTCTAACAGTTTTTTTATTTGTTTTGTAGAGACGGGTTTTGGTTTATTGCTCAGGCTGGTTTCAAACTC
CTAGGCTCAAGCGGTCCTCCCACTGTGGCCTCCCAAAGTGCTGGGTGGTGTGAGCCACCGTGCCTGGCCAGTTAATTTTTTTTAGTGTCT
CTTTTTTGGGTTCTCACCAGAAACACTATCAGCATTCCCACAGATATTCCTGTGAGTCTTTGAAACATTTTCTATCCTGCATTGAGTAAG
AATAAAACCGAGGAAGGGGTGAAGCACCTTGTCTCATCCCCAGTCTGGAACTTGAACCTTCTTTTCTCTTCACTTTGCCCTACCCCCAAA
TAATATGTACAAATGTCTGTATCCATTGAGCACTAACTCCCTATTCCTTCCACCTCCCCAGCCCCTGGCAACCACTGTTCTACGTTCTGT
CTCTACGAATTTGACTTCTCTAGGTCCCTCATACAAGTGGAAAAGTACAGCATGTCTTTTTGTGACCGGCTTATTTCACTTAGCATAATG
TCCTCAAGGTTCATCCATGCTGTAGCATGTGTCAGAATTGCCTTCTTGCTTGAGGCTGCTGATACCTCCTCATGTGTATATACCGTATTT
TGTTTAATCACTCATCTGTTGGTGGACACTTGGGTTGCCTCCACCTCTTGGCTGTTGCAAATAACGCTGTGAACATGGATATACAGATAT
CTGAGGCCAGGCCAGGCGTTCACACCTGTAATCCCAATACGTTGGGAGGCCGAGGCGGGCAGATCATCTGAGGTCAGGATTCGAGACCAC
CCTGGCCAACATGGCAAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCGCGCCTATAATCCCAGCTACTCGGG
AGGCTGAGGCAGGAGAATCTTGAACTCAGGAGGTGGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGTGACAGAGTG
AGATTCCGTCTCAAAAAAAAAAAAAAACAAAAACTCAGACCCTGCTTTCCTTTGAATATATACTAGAAGTGGAATTGCTGGATCATATGG
TAATTCTTTAATTTTTCTGGGGGAACTGCTGTCCCATTTTCCACAGCAGCTACACCATTTTATGTTCCCACCAACGGTGTACAACAATTT
CAATTTCTCCACATCCTTGTTCTTGTTAATAGTAGCCACCCTAATGTGTATGAGGTGCCATCTCGTGGTTTGGTGTGGGCTGTGTTTCAA
TCAGATGTTGGGACCCTTAAGTGTTCTGCACCTGGGGAGAGTTAGGAACCACTTAAGGAGTGTCTGTTGCTTGCCAATCTTAAAATTTTT
AGTTTGCACCTGAATCAGGGGCTGTCAGAGTCCAGACTGCTCTTGAAATAGAAAAGACTGGTCGTTAAAGGCTGGTTCGTTGAGTCTTTC
ATCGTTGAGTGATACCACCTCTGCAGATGGCTCAGTGGGGCAGCCCCGTACCACAGCCTGCCCTTGAGGTTGTGTAGTTTAGATAGGTCA
CAGAGTTGCTGGGCCTACCGCAGGTCTCCTGACCCTGGTGCAGTTTTACTTCAATTACAACCACCAAAATAGCTACAGTCAAAAATTCCA
AAGTTCCTACACCATCAACCTCCACCCCACTTCCGTCCAAAGTCCACTTAGAGGCTCTCAGTTTTGGACCTTAGAAACACTTAGGGAGCT
TTTTAAAAAGATCGATTCTGTATTTTTAGTAGAGATGGGGTTTCACCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCGGG
GAGTTGGAGGTTGCAGTGAGCCGAGATTATGTCACTCCAGCCTGGGCAACAGAGTGAGACTCCGTCTTAGGAAAAAAAAAAAGATTGATT
CTGGCCGGGCACAGTGGCTCACGCTTACAGTCCCAGCACTTTAAGAGACTCAGGCAGGAGGATCACTTGAGCTTAGGAGTTTGAGACTAG
CCTGGGCAACCCAGTGAGACCCCGTATCTACAAAAATTAGCCAGGTGTTGTGACATGTGCCTGTGGTCCCAGCTACTCAAGAGGCTGAGG
TGAGAGGAGCAAGTGAGCCCAGGAGTTCAAGGCTGCAATGAGCTGTGATCGCACCACTGCACTCCAGCTCGGGTGACAAGAGTGAGACCC
CGTCTGAAAAAAAGATTGATCCCAAGGCCTTGCCCAGATTCTGATTTTATTGGCCTGGAGTGTGGCCTAGGCATTAGAAAATCTTCAAGA
GAGTCTAAGGTGCAGCGGAATTGAGAGCCACGGACAGAAAAAGCCCTAAATTGTGGAAATGCACAGCCACCGTCACCACCTATCGGTACG
ATGACATCTCAAGGAGTCACTGGCCCTAGGTTTCTGCAGTAGGATCTTAAGATCTGATCTCTGCCCTCAAGTGAGTGCACGTGCAGTAAA
GCTGTCATCGTGCCATGACAGATGTCTGCAAGGACTTTACAGTGGGGTCCAAAGGATGCCACCATCAGCTCCACCTGGGGCTCAACAAAG
CCTGAAAGAAGAAAGGGATGATGCTTCCAGCAGAAACCTGGAGGCCTGCAGCTCTGCCAGCCCAGCACAGCAAGCGAGGCCATTTGTCCA
GCAGGGGCAGAAGGAGGGAACTCAGCCAGCCAGCGTTTCCTACAAGCAGCTCCATGAGAGGTTTCCACTTAAAATGCTAAATCATAATTA
TTTAATCAGATTCGTTCCTTAAGTTCTTTAAGCAGCATCGCTGTCCTACCACGAGTGGTCATCAAGGAGCAGGGTTTAACTCAACTCTGA
GTTACCCGGCAGGGTACCTGGGTAACTGCCTGGGTTGAGGTACCCAGCAGGCTTCATGTGCATGTGCACACTGCCCCCTGATAGGACCTG
GTTTATTCACAGGCTCAGGTGTCACTGCAGCTCCCCAGTGACTATCTTCGCGCAAGTTGGACTCAATGGCCTGGGAGGTTTGTCCCAGCC
GACAGATACCTGACCATGCCCATCCTCACCATTCCCTCCCCCATGCTGCATCCATCCAACCTTGATCTCCACTGTGTCCCAGGCACCCTA
AGATGCACAAGCTATGTGGGCCCTGCCCTCACAGAACTTGTAGTCTTCTGCCCCAAACAAGCCAGTTCACCGTCTTCATGATCAGGCCAA
AGGTTGAGGTACCCAGCAGGCTTCATATGCACATGCACACTGTCCCCTATAGGACCATGCCTTGCCCAGCTGGCTGCACTCTAGAGGGTG
CTTTGTAGGAAGGACAGAGTGGAGAGGACAGTGGGGAGGTACTTGGGTGTTCAACAGCCAGAAGGGAGGGAAACTGAAAAAGAATCAGGA
GTCCAGCCATCCCCTCCCCACCTCCTGCCCCCACTTCCACCCTGGCTGCTGGCCCTTTGCCCTTGAATATGGGTGATATAGGTGTGGCTA
TTCAGTTCCAGTCACAGTGCTGCCTCTATGTCTTTTGCAAGCTGGGGTCTTCCTTACTCAGAAGGCCTGGAGGCCCTGCCAGATGCTGCC
TTCCGGACTGGCTGCCCGCTGCAGTGTTTTCACGGGAGCCAAGCCAGCCCCGGGCCTGTAGCCTCCCATGTGACAAAGTTTCAGACACCA
CAGTCCTCAGCTGGACCACAGTAAACACTTGCCTTCCCCAACCCATGATTCTTGCTTGGAAACATGAACCTGATGTTCCACGTGCGTTCA
GCCAATCAAACCTCAAGAATGTGATTGAGCAGTGAGGCTGCGTTTTGGGCAAGACACTGAGCTCTGAAATAAGACTTTTCTTGGAATCTC
AAGCCCTCAACTTACAGTGGGACCCTAAGAAATGCACTTCAGTTTCCTTTTATGTAAAATGGTGGTAAAATTAATTGTGTTCATTAAATT
GCACACAACTATACATGTTTACCTATACACTAAGTGGTTCTCAACTTGGGGCAATTTGCCCCCCAGGGGACATTCAGCAGTGTCTGCGGA
CATTTTTTGTTGCTACTGGAGGGAGGTGCTACTGGCATCTAGGGAGTGGAGGCTAGAGATGCTGCTAAACTACAGTCCACAGGACAGTCT
CCACAGCAAAGAATTGTCCAGCCCCAAATATCAATAATGCCGAGGTTGAGGAAACCCTGCCACATACACATAGATGCGGGTTAACATTGT
TTATTTTACAAAGTGGAATCATTTACATTTTAGCCATTCTGATAGATGAAGCAGTGGCATCTTTTTTTTTTTTTTTTTTTTTTTGAGACG
GGGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGGGTTGCAATCACGGCTCACAGCAGCCTCGAAGTCCCAGGACCAAGCAACCCTCCCAC
CGCAGCCTTCCAAGTAACTGGGACTACAGGCACACAACACCATGCCCAGCTAATTTTTTAATTTTTTTGTAGAGACGGGGTTTCACCATG
TTGCCCAGGCTCAAACTCCTGAGCTCACACGATCTGCTGCCTTCACCTTCCAAAGTGCTGGGATTACAGGTGTAAGCCACTATGCCCAGC

>20398_20398_1_CTNND2-POLR1A_CTNND2_chr5_11732248_ENST00000304623_POLR1A_chr2_86257519_ENST00000263857_length(amino acids)=252AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKG
ITRCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRVIEKEIKDVFAVYGIAVDPRHLSLVADYM

--------------------------------------------------------------
>20398_20398_2_CTNND2-POLR1A_CTNND2_chr5_11732248_ENST00000304623_POLR1A_chr2_86257519_ENST00000409681_length(transcript)=2044nt_BP=364nt
GCGTCGGGAGCCGCCTCTCGCCCGCGGCGCTCGCCCCTGCCGCCCGCCAGCATCCCTTGTCCCGCGGCCGCGCTCAGACAACAAAAGCGG
AAGATGCTGCAGTTGGGCAAGGTCAGGACCTTGCCCTGAAGCCGGGCGGCGCCGCGCACGCCTCTTCCCGGACTGAGGAGCTGTCGCCGG
CGGAGGGTGCATGTTTGCGAGGAAGCCGCCGGGCGCCGCGCCTTTGGGAGCTATGCCTGTTCCAGACCAGCCTTCATCAGCCTCAGAGAA
GACGAGTTCCCTGAGCCCCGGCTTAAACACCTCCAACGGGGATGGCTCTGAAACAGAAACCACCTCTGCCATCCTCGCCTCAGTCAAAGA
ACAGGTGACAGTGAAGCTCCCTCTGATGAAGATCAACTTTGACATGAGCTCCCTGGTAGTATCTTTGGCCCATGGTGCCGTCATCTATGC
GACCAAGGGCATCACTCGGTGCCTCCTGAATGAAACAACCAACAATAAGAACGAGAAGGAGCTTGTGCTAAACACAGAAGGAATCAACCT
CCCAGAGCTATTCAAGTATGCAGAGGTCCTGGATCTGCGCCGCCTCTACTCCAACGACATCCACGCCATAGCCAACACGTATGGCATTGA
GGCCGCGCTGCGGGTGATCGAGAAGGAGATCAAGGATGTGTTTGCCGTGTATGGCATCGCGGTCGACCCTCGCCATCTCTCCCTGGTTGC
TGATTATATGTGCTTCGAGGGTGTTTACAAGCCACTGAATCGCTTTGGGATCCGGTCAAACTCTTCCCCGCTACAGCAGATGACATTTGA
AACCAGCTTCCAGTTTCTGAAGCAAGCCACCATGCTGGGATCCCACGATGAGCTGAGGTCTCCTTCTGCCTGCCTTGTGGTCGGGAAGGT
CGTCAGGGGCGGGACAGGCCTGTTCGAGCTCAAGCAGCCTCTGAGATAGCAGCTACCCCGGCACCATCTGCCCAGCTCCAAGGACCCTTG
GTGAGGGCGTGGCCCAGCCTGCCTTCTGCATGAGAGGACCAGGAGACTGGAATCCAGGGCAGTTCCAAGTGACAGTACAGAGCACAGCAG
CGACCTTGGGCCTGAAAGCAGTGGGCCTCTGAGCTGGGCCAGCTTCACCTGGAAAGTGACAGAGTTGCTCATCCTTGCCCCTCCCTGTCT
CTGGATTTTTATCAAGGTTTACCAAGTCTTCTGAGTCCCCCTGAGATGGCTGGGGCCTCACCTGTGCTGCAGGAGGCCTCTGTGGCATAA
CCCCTAAGGAGAAGTCCTGATTCACGATTCACTGAGAAGACCAAGGGGAAGCCATGCTTTGCTGCTGGGGACCCCAGGCACCTCCAGAGT
AGGGAAGCGGGGTTCTTTTGCTGTGAGTGGCCAGGGACAACAGACAAGATTCCTGGGGGCTCCCGATGAGCAGGAACGTGGAGCCTGCTG
CCCAAGGCCTGCTCCTTCCGGCTGCTCCAGCCCCTGGGGGCAGAGTCCACAAAGAGTCCCCATCAAGACTTCTTCCCTGAGTCAAGTACA
GCGTAGCATAGTCCTCCACCCACCCAACCTCTCTGCCTGGCCAGGGTCCTGGCCCTGCCACTGTGTGGCGAGGTGTCCTTCTAGACCACA
TCAGCCCCAAGGCTGGGAGCAGTCGCTCCAGGGCCGCAGCAGTTCACTCCCACACATAGAACCCAGGTCACTGCTGGGGCGATTGAACAG
GTTGCCTGGCTTTTCTCTGCTGTCAGTTTGGTGTGGAGGCCTATGTTCTGCCCCATACACCCCACAGGCCCTGCTTATGGGAAGGAACAC
AGGCCTCCAGCCCAGAGGACTGTGCCGCCCTGTTCTTGGCCGTCCACGTTTCCTCTCCCTCTAGCACCAGCAATACATTTCCCTGGCATG
GACAGAAAAGACAGAGAGGACTTATACAAAGGCTTTGTAAAACCAGAGGCTAGCTTCTATCTTTGTCTACTGTTATTTCAGCTCAGGGCG

>20398_20398_2_CTNND2-POLR1A_CTNND2_chr5_11732248_ENST00000304623_POLR1A_chr2_86257519_ENST00000409681_length(amino acids)=252AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKG
ITRCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRVIEKEIKDVFAVYGIAVDPRHLSLVADYM

--------------------------------------------------------------
>20398_20398_3_CTNND2-POLR1A_CTNND2_chr5_11732248_ENST00000359640_POLR1A_chr2_86257519_ENST00000263857_length(transcript)=8111nt_BP=319nt
GCCAGCATCCCTTGTCCCGCGGCCGCGCTCAGACAACAAAAGCGGAAGATGCTGCAGTTGGGCAAGGTCAGGACCTTGCCCTGAAGCCGG
GCGGCGCCGCGCACGCCTCTTCCCGGACTGAGGAGCTGTCGCCGGCGGAGGGTGCATGTTTGCGAGGAAGCCGCCGGGCGCCGCGCCTTT
GGGAGCTATGCCTGTTCCAGACCAGCCTTCATCAGCCTCAGAGAAGACGAGTTCCCTGAGCCCCGGCTTAAACACCTCCAACGGGGATGG
CTCTGAAACAGAAACCACCTCTGCCATCCTCGCCTCAGTCAAAGAACAGGTGACAGTGAAGCTCCCTCTGATGAAGATCAACTTTGACAT
GAGCTCCCTGGTAGTATCTTTGGCCCATGGTGCCGTCATCTATGCGACCAAGGGCATCACTCGGTGCCTCCTGAATGAAACAACCAACAA
TAAGAACGAGAAGGAGCTTGTGCTAAACACAGAAGGAATCAACCTCCCAGAGCTATTCAAGTATGCAGAGGTCCTGGATCTGCGCCGCCT
CTACTCCAACGACATCCACGCCATAGCCAACACGTATGGCATTGAGGCCGCGCTGCGGGTGATCGAGAAGGAGATCAAGGATGTGTTTGC
CGTGTATGGCATCGCGGTCGACCCTCGCCATCTCTCCCTGGTTGCTGATTATATGTGCTTCGAGGGTGTTTACAAGCCACTGAATCGCTT
TGGGATCCGGTCAAACTCTTCCCCGCTACAGCAGATGACATTTGAAACCAGCTTCCAGTTTCTGAAGCAAGCCACCATGCTGGGATCCCA
CGATGAGCTGAGGTCTCCTTCTGCCTGCCTTGTGGTCGGGAAGGTCGTCAGGGGCGGGACAGGCCTGTTCGAGCTCAAGCAGCCTCTGAG
ATAGCAGCTACCCCGGCACCATCTGCCCAGCTCCAAGGACCCTTGGTGAGGGCGTGGCCCAGCCTGCCTTCTGCATGAGAGGACCAGGAG
ACTGGAATCCAGGGCAGTTCCAAGTGACAGTACAGAGCACAGCAGCGACCTTGGGCCTGAAAGCAGTGGGCCTCTGAGCTGGGCCAGCTT
CACCTGGAAAGTGACAGAGTTGCTCATCCTTGCCCCTCCCTGTCTCTGGATTTTTATCAAGGTTTACCAAGTCTTCTGAGTCCCCCTGAG
ATGGCTGGGGCCTCACCTGTGCTGCAGGAGGCCTCTGTGGCATAACCCCTAAGGAGAAGTCCTGATTCACGATTCACTGAGAAGACCAAG
GGGAAGCCATGCTTTGCTGCTGGGGACCCCAGGCACCTCCAGAGTAGGGAAGCGGGGTTCTTTTGCTGTGAGTGGCCAGGGACAACAGAC
AAGATTCCTGGGGGCTCCCGATGAGCAGGAACGTGGAGCCTGCTGCCCAAGGCCTGCTCCTTCCGGCTGCTCCAGCCCCTGGGGGCAGAG
TCCACAAAGAGTCCCCATCAAGACTTCTTCCCTGAGTCAAGTACAGCGTAGCATAGTCCTCCACCCACCCAACCTCTCTGCCTGGCCAGG
GTCCTGGCCCTGCCACTGTGTGGCGAGGTGTCCTTCTAGACCACATCAGCCCCAAGGCTGGGAGCAGTCGCTCCAGGGCCGCAGCAGTTC
ACTCCCACACATAGAACCCAGGTCACTGCTGGGGCGATTGAACAGGTTGCCTGGCTTTTCTCTGCTGTCAGTTTGGTGTGGAGGCCTATG
TTCTGCCCCATACACCCCACAGGCCCTGCTTATGGGAAGGAACACAGGCCTCCAGCCCAGAGGACTGTGCCGCCCTGTTCTTGGCCGTCC
ACGTTTCCTCTCCCTCTAGCACCAGCAATACATTTCCCTGGCATGGACAGAAAAGACAGAGAGGACTTATACAAAGGCTTTGTAAAACCA
GAGGCTAGCTTCTATCTTTGTCTACTGTTATTTCAGCTCAGGGCGGGTAATTAACATCATTGGAACTAGCTATTAGGAAAGAAAAAAAAC
TTGGTTTTTTTTACAACAATTTTTTCCCTTGGTTTGCAGTTTCTGCATTTGGATTTGAGAACCCAGGGCGGGGATTTTCTTGGCACAGTC
AGGTCTTGGGTCCCTCTTCCTGTGCTTTCTTGTCTGAGGCCTTAGGGGGAAGAGCTCAGCCTCTGCAGCCTCCTCCACCTCTGCCCCTGG
CCTGCCTCTGCTGTGACCTCCTTCCAGAGCTAGCTGCTGGCCCTGTGGCCAGGAGAAGCAGAGGGGAGAAGCCTTTATGCAGAAGCTGTG
CTAGCCTTGGTCTGGGGTGGGGAGGCTGCTGCTGTGACCTTAGGGGTAGGGTTGGGGATCAAGGGAGGCTTTGTCAAGGGAGAGTGACCA
TGTTGCTCCCTACATCCATGCAATAGGACCCAGCCTGCACCTCCTAGGCCTACACTGGGGAAAGCCTGACAGAAATCAGTACCTCCTAAC
GGGGTCTGCCAGGTTCACCAAGGCATGGGCACAGAGGAATATGACAGTTTTGAGGCAGGCAGGAAGGGCCCAGCCTGCAGGGTAAGACAT
TCATTCTTTGAGTTAAAGGCCATATTCACTTGATGATTTCTACACACACTAGAATTGTGAGAGTGTCCTTGAAGGAGATCACAAAGTAAC
CTGGTGACTGTGGCACAGGGTCCGTGGATTCCATCTCTCCCAGGCACTGAGGGCGCAGAGGCGAAGGAGCAAGCCCTGCATATTGGCAGG
GCTGTGACCATCGCACTTAGATCAGACCCCCGACCTGTGTTGGGATGTGAGGGATGCCCTCCTGCCCCACCCATCCACATGGTTCCTGGG
CAGCTCTGTTTTATTCCTGTGTCTTTCCTGATGGATGAGTATTAAGACAGCATGTCTGGTTTTTAAACAGACATTTGGGAGCTTGCACAT
CCTGATGAGCAGGGACTCACTGTGGTGGCCTTAGGGAATTACACGCTCACTTTGGTGGTTCTCTATGCTCGGAAGCCTCTGAGAGTGGCC
TTGGCAGCTTAAGATGGCAGAGGCTTTGGAGTCTTCTTAGGACTGTAAGTGCCCATTGAGGATGCATTTGAGTTTTGGAAAGTAGGCCCA
AGTCAAATCTGATGGATGGATTCAAGAACATGGACTAATCTGCGTTGTCATTTTTAATCAAAATGTAATGGAGATTGATCATCTGGTGGG
GTTCACAAACTTTTCATGAGAGCTGTGAGTTCTTTTTTTGAGATGCACTTTTGCACTTGTTACCCAGGCTGAGTGCAATGGCGCAATCTC
GGCTCCACTGCAACCTCCATCTCCCGAGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGAGATTACAGGCATGCGCCACCACG
CCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTAGTCTCGAACTCCTAATCTCAGGTGATCCGCCTG
CCTCAGCCTCCCAAAGTGCTGGGTTTACAGGCGTGAGCTACTGTGCCGGCCAGAGCTATGAGTTCTTTCAGAATCCTCAGATGCCATTAG
CTAGCCACTGTTTGGACATCCTTCTCACCTTGCCCTTTGGGGTGATATCCATACCTACTTGCTTGCTTCTAACAGTTTTTTTATTTGTTT
TGTAGAGACGGGTTTTGGTTTATTGCTCAGGCTGGTTTCAAACTCCTAGGCTCAAGCGGTCCTCCCACTGTGGCCTCCCAAAGTGCTGGG
TGGTGTGAGCCACCGTGCCTGGCCAGTTAATTTTTTTTAGTGTCTCTTTTTTGGGTTCTCACCAGAAACACTATCAGCATTCCCACAGAT
ATTCCTGTGAGTCTTTGAAACATTTTCTATCCTGCATTGAGTAAGAATAAAACCGAGGAAGGGGTGAAGCACCTTGTCTCATCCCCAGTC
TGGAACTTGAACCTTCTTTTCTCTTCACTTTGCCCTACCCCCAAATAATATGTACAAATGTCTGTATCCATTGAGCACTAACTCCCTATT
CCTTCCACCTCCCCAGCCCCTGGCAACCACTGTTCTACGTTCTGTCTCTACGAATTTGACTTCTCTAGGTCCCTCATACAAGTGGAAAAG
TACAGCATGTCTTTTTGTGACCGGCTTATTTCACTTAGCATAATGTCCTCAAGGTTCATCCATGCTGTAGCATGTGTCAGAATTGCCTTC
TTGCTTGAGGCTGCTGATACCTCCTCATGTGTATATACCGTATTTTGTTTAATCACTCATCTGTTGGTGGACACTTGGGTTGCCTCCACC
TCTTGGCTGTTGCAAATAACGCTGTGAACATGGATATACAGATATCTGAGGCCAGGCCAGGCGTTCACACCTGTAATCCCAATACGTTGG
GAGGCCGAGGCGGGCAGATCATCTGAGGTCAGGATTCGAGACCACCCTGGCCAACATGGCAAAACCCCATCTCTACTAAAAATACAAAAA
TTAGCTGGGTGTGGTGGTGCGCGCCTATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCTTGAACTCAGGAGGTGGAGGTTGCAG
TGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGATTCCGTCTCAAAAAAAAAAAAAAACAAAAACTCAGACCCTGC
TTTCCTTTGAATATATACTAGAAGTGGAATTGCTGGATCATATGGTAATTCTTTAATTTTTCTGGGGGAACTGCTGTCCCATTTTCCACA
GCAGCTACACCATTTTATGTTCCCACCAACGGTGTACAACAATTTCAATTTCTCCACATCCTTGTTCTTGTTAATAGTAGCCACCCTAAT
GTGTATGAGGTGCCATCTCGTGGTTTGGTGTGGGCTGTGTTTCAATCAGATGTTGGGACCCTTAAGTGTTCTGCACCTGGGGAGAGTTAG
GAACCACTTAAGGAGTGTCTGTTGCTTGCCAATCTTAAAATTTTTAGTTTGCACCTGAATCAGGGGCTGTCAGAGTCCAGACTGCTCTTG
AAATAGAAAAGACTGGTCGTTAAAGGCTGGTTCGTTGAGTCTTTCATCGTTGAGTGATACCACCTCTGCAGATGGCTCAGTGGGGCAGCC
CCGTACCACAGCCTGCCCTTGAGGTTGTGTAGTTTAGATAGGTCACAGAGTTGCTGGGCCTACCGCAGGTCTCCTGACCCTGGTGCAGTT
TTACTTCAATTACAACCACCAAAATAGCTACAGTCAAAAATTCCAAAGTTCCTACACCATCAACCTCCACCCCACTTCCGTCCAAAGTCC
ACTTAGAGGCTCTCAGTTTTGGACCTTAGAAACACTTAGGGAGCTTTTTAAAAAGATCGATTCTGTATTTTTAGTAGAGATGGGGTTTCA
CCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCGGGGAGTTGGAGGTTGCAGTGAGCCGAGATTATGTCACTCCAGCCTGG
GCAACAGAGTGAGACTCCGTCTTAGGAAAAAAAAAAAGATTGATTCTGGCCGGGCACAGTGGCTCACGCTTACAGTCCCAGCACTTTAAG
AGACTCAGGCAGGAGGATCACTTGAGCTTAGGAGTTTGAGACTAGCCTGGGCAACCCAGTGAGACCCCGTATCTACAAAAATTAGCCAGG
TGTTGTGACATGTGCCTGTGGTCCCAGCTACTCAAGAGGCTGAGGTGAGAGGAGCAAGTGAGCCCAGGAGTTCAAGGCTGCAATGAGCTG
TGATCGCACCACTGCACTCCAGCTCGGGTGACAAGAGTGAGACCCCGTCTGAAAAAAAGATTGATCCCAAGGCCTTGCCCAGATTCTGAT
TTTATTGGCCTGGAGTGTGGCCTAGGCATTAGAAAATCTTCAAGAGAGTCTAAGGTGCAGCGGAATTGAGAGCCACGGACAGAAAAAGCC
CTAAATTGTGGAAATGCACAGCCACCGTCACCACCTATCGGTACGATGACATCTCAAGGAGTCACTGGCCCTAGGTTTCTGCAGTAGGAT
CTTAAGATCTGATCTCTGCCCTCAAGTGAGTGCACGTGCAGTAAAGCTGTCATCGTGCCATGACAGATGTCTGCAAGGACTTTACAGTGG
GGTCCAAAGGATGCCACCATCAGCTCCACCTGGGGCTCAACAAAGCCTGAAAGAAGAAAGGGATGATGCTTCCAGCAGAAACCTGGAGGC
CTGCAGCTCTGCCAGCCCAGCACAGCAAGCGAGGCCATTTGTCCAGCAGGGGCAGAAGGAGGGAACTCAGCCAGCCAGCGTTTCCTACAA
GCAGCTCCATGAGAGGTTTCCACTTAAAATGCTAAATCATAATTATTTAATCAGATTCGTTCCTTAAGTTCTTTAAGCAGCATCGCTGTC
CTACCACGAGTGGTCATCAAGGAGCAGGGTTTAACTCAACTCTGAGTTACCCGGCAGGGTACCTGGGTAACTGCCTGGGTTGAGGTACCC
AGCAGGCTTCATGTGCATGTGCACACTGCCCCCTGATAGGACCTGGTTTATTCACAGGCTCAGGTGTCACTGCAGCTCCCCAGTGACTAT
CTTCGCGCAAGTTGGACTCAATGGCCTGGGAGGTTTGTCCCAGCCGACAGATACCTGACCATGCCCATCCTCACCATTCCCTCCCCCATG
CTGCATCCATCCAACCTTGATCTCCACTGTGTCCCAGGCACCCTAAGATGCACAAGCTATGTGGGCCCTGCCCTCACAGAACTTGTAGTC
TTCTGCCCCAAACAAGCCAGTTCACCGTCTTCATGATCAGGCCAAAGGTTGAGGTACCCAGCAGGCTTCATATGCACATGCACACTGTCC
CCTATAGGACCATGCCTTGCCCAGCTGGCTGCACTCTAGAGGGTGCTTTGTAGGAAGGACAGAGTGGAGAGGACAGTGGGGAGGTACTTG
GGTGTTCAACAGCCAGAAGGGAGGGAAACTGAAAAAGAATCAGGAGTCCAGCCATCCCCTCCCCACCTCCTGCCCCCACTTCCACCCTGG
CTGCTGGCCCTTTGCCCTTGAATATGGGTGATATAGGTGTGGCTATTCAGTTCCAGTCACAGTGCTGCCTCTATGTCTTTTGCAAGCTGG
GGTCTTCCTTACTCAGAAGGCCTGGAGGCCCTGCCAGATGCTGCCTTCCGGACTGGCTGCCCGCTGCAGTGTTTTCACGGGAGCCAAGCC
AGCCCCGGGCCTGTAGCCTCCCATGTGACAAAGTTTCAGACACCACAGTCCTCAGCTGGACCACAGTAAACACTTGCCTTCCCCAACCCA
TGATTCTTGCTTGGAAACATGAACCTGATGTTCCACGTGCGTTCAGCCAATCAAACCTCAAGAATGTGATTGAGCAGTGAGGCTGCGTTT
TGGGCAAGACACTGAGCTCTGAAATAAGACTTTTCTTGGAATCTCAAGCCCTCAACTTACAGTGGGACCCTAAGAAATGCACTTCAGTTT
CCTTTTATGTAAAATGGTGGTAAAATTAATTGTGTTCATTAAATTGCACACAACTATACATGTTTACCTATACACTAAGTGGTTCTCAAC
TTGGGGCAATTTGCCCCCCAGGGGACATTCAGCAGTGTCTGCGGACATTTTTTGTTGCTACTGGAGGGAGGTGCTACTGGCATCTAGGGA
GTGGAGGCTAGAGATGCTGCTAAACTACAGTCCACAGGACAGTCTCCACAGCAAAGAATTGTCCAGCCCCAAATATCAATAATGCCGAGG
TTGAGGAAACCCTGCCACATACACATAGATGCGGGTTAACATTGTTTATTTTACAAAGTGGAATCATTTACATTTTAGCCATTCTGATAG
ATGAAGCAGTGGCATCTTTTTTTTTTTTTTTTTTTTTTTGAGACGGGGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGGGTTGCAATCAC
GGCTCACAGCAGCCTCGAAGTCCCAGGACCAAGCAACCCTCCCACCGCAGCCTTCCAAGTAACTGGGACTACAGGCACACAACACCATGC
CCAGCTAATTTTTTAATTTTTTTGTAGAGACGGGGTTTCACCATGTTGCCCAGGCTCAAACTCCTGAGCTCACACGATCTGCTGCCTTCA
CCTTCCAAAGTGCTGGGATTACAGGTGTAAGCCACTATGCCCAGCCTCATTTGTACTTCAGTTTGCAATTCTCTATTAATAAATCTAAGC

>20398_20398_3_CTNND2-POLR1A_CTNND2_chr5_11732248_ENST00000359640_POLR1A_chr2_86257519_ENST00000263857_length(amino acids)=252AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKG
ITRCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRVIEKEIKDVFAVYGIAVDPRHLSLVADYM

--------------------------------------------------------------
>20398_20398_4_CTNND2-POLR1A_CTNND2_chr5_11732248_ENST00000359640_POLR1A_chr2_86257519_ENST00000409681_length(transcript)=1999nt_BP=319nt
GCCAGCATCCCTTGTCCCGCGGCCGCGCTCAGACAACAAAAGCGGAAGATGCTGCAGTTGGGCAAGGTCAGGACCTTGCCCTGAAGCCGG
GCGGCGCCGCGCACGCCTCTTCCCGGACTGAGGAGCTGTCGCCGGCGGAGGGTGCATGTTTGCGAGGAAGCCGCCGGGCGCCGCGCCTTT
GGGAGCTATGCCTGTTCCAGACCAGCCTTCATCAGCCTCAGAGAAGACGAGTTCCCTGAGCCCCGGCTTAAACACCTCCAACGGGGATGG
CTCTGAAACAGAAACCACCTCTGCCATCCTCGCCTCAGTCAAAGAACAGGTGACAGTGAAGCTCCCTCTGATGAAGATCAACTTTGACAT
GAGCTCCCTGGTAGTATCTTTGGCCCATGGTGCCGTCATCTATGCGACCAAGGGCATCACTCGGTGCCTCCTGAATGAAACAACCAACAA
TAAGAACGAGAAGGAGCTTGTGCTAAACACAGAAGGAATCAACCTCCCAGAGCTATTCAAGTATGCAGAGGTCCTGGATCTGCGCCGCCT
CTACTCCAACGACATCCACGCCATAGCCAACACGTATGGCATTGAGGCCGCGCTGCGGGTGATCGAGAAGGAGATCAAGGATGTGTTTGC
CGTGTATGGCATCGCGGTCGACCCTCGCCATCTCTCCCTGGTTGCTGATTATATGTGCTTCGAGGGTGTTTACAAGCCACTGAATCGCTT
TGGGATCCGGTCAAACTCTTCCCCGCTACAGCAGATGACATTTGAAACCAGCTTCCAGTTTCTGAAGCAAGCCACCATGCTGGGATCCCA
CGATGAGCTGAGGTCTCCTTCTGCCTGCCTTGTGGTCGGGAAGGTCGTCAGGGGCGGGACAGGCCTGTTCGAGCTCAAGCAGCCTCTGAG
ATAGCAGCTACCCCGGCACCATCTGCCCAGCTCCAAGGACCCTTGGTGAGGGCGTGGCCCAGCCTGCCTTCTGCATGAGAGGACCAGGAG
ACTGGAATCCAGGGCAGTTCCAAGTGACAGTACAGAGCACAGCAGCGACCTTGGGCCTGAAAGCAGTGGGCCTCTGAGCTGGGCCAGCTT
CACCTGGAAAGTGACAGAGTTGCTCATCCTTGCCCCTCCCTGTCTCTGGATTTTTATCAAGGTTTACCAAGTCTTCTGAGTCCCCCTGAG
ATGGCTGGGGCCTCACCTGTGCTGCAGGAGGCCTCTGTGGCATAACCCCTAAGGAGAAGTCCTGATTCACGATTCACTGAGAAGACCAAG
GGGAAGCCATGCTTTGCTGCTGGGGACCCCAGGCACCTCCAGAGTAGGGAAGCGGGGTTCTTTTGCTGTGAGTGGCCAGGGACAACAGAC
AAGATTCCTGGGGGCTCCCGATGAGCAGGAACGTGGAGCCTGCTGCCCAAGGCCTGCTCCTTCCGGCTGCTCCAGCCCCTGGGGGCAGAG
TCCACAAAGAGTCCCCATCAAGACTTCTTCCCTGAGTCAAGTACAGCGTAGCATAGTCCTCCACCCACCCAACCTCTCTGCCTGGCCAGG
GTCCTGGCCCTGCCACTGTGTGGCGAGGTGTCCTTCTAGACCACATCAGCCCCAAGGCTGGGAGCAGTCGCTCCAGGGCCGCAGCAGTTC
ACTCCCACACATAGAACCCAGGTCACTGCTGGGGCGATTGAACAGGTTGCCTGGCTTTTCTCTGCTGTCAGTTTGGTGTGGAGGCCTATG
TTCTGCCCCATACACCCCACAGGCCCTGCTTATGGGAAGGAACACAGGCCTCCAGCCCAGAGGACTGTGCCGCCCTGTTCTTGGCCGTCC
ACGTTTCCTCTCCCTCTAGCACCAGCAATACATTTCCCTGGCATGGACAGAAAAGACAGAGAGGACTTATACAAAGGCTTTGTAAAACCA
GAGGCTAGCTTCTATCTTTGTCTACTGTTATTTCAGCTCAGGGCGGGTAATTAACATCATTGGAACTAGCTATTAGGAAAGAAAAAAAAC

>20398_20398_4_CTNND2-POLR1A_CTNND2_chr5_11732248_ENST00000359640_POLR1A_chr2_86257519_ENST00000409681_length(amino acids)=252AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKG
ITRCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRVIEKEIKDVFAVYGIAVDPRHLSLVADYM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CTNND2-POLR1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CTNND2-POLR1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CTNND2-POLR1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCTNND2C0007621Neoplastic Cell Transformation1CTD_human
HgeneCTNND2C0017636Glioblastoma1CTD_human
HgeneCTNND2C0036341Schizophrenia1PSYGENET
HgeneCTNND2C0041696Unipolar Depression1PSYGENET
HgeneCTNND2C0334588Giant Cell Glioblastoma1CTD_human
HgeneCTNND2C1269683Major Depressive Disorder1PSYGENET
HgeneCTNND2C1621958Glioblastoma Multiforme1CTD_human
HgeneCTNND2C1832841EPILEPSY, FAMILIAL ADULT MYOCLONIC, 11ORPHANET
HgeneCTNND2C3495676Anorectal Malformations1GENOMICS_ENGLAND
TgeneC4225317ACROFACIAL DYSOSTOSIS, CINCINNATI TYPE2CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0025990Micrognathism1GENOMICS_ENGLAND
TgeneC1332140Acrofacial Dysostosis1GENOMICS_ENGLAND
TgeneC1837822Burn-Mckeown syndrome1ORPHANET