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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TTLL9-CTNNB1 (FusionGDB2 ID:HG164395TG1499)

Fusion Gene Summary for TTLL9-CTNNB1

check button Fusion gene summary
Fusion gene informationFusion gene name: TTLL9-CTNNB1
Fusion gene ID: hg164395tg1499
HgeneTgene
Gene symbol

TTLL9

CTNNB1

Gene ID

164395

1499

Gene nametubulin tyrosine ligase like 9catenin beta 1
SynonymsC20orf125CTNNB|EVR7|MRD19|NEDSDV|armadillo
Cytomap('TTLL9')('CTNNB1')

20q11.21

3p22.1

Type of geneprotein-codingprotein-coding
Descriptionprobable tubulin polyglutamylase TTLL9tubulin tyrosine ligase-like family, member 9tubulin--tyrosine ligase-like protein 9catenin beta-1catenin (cadherin-associated protein), beta 1, 88kDa
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000310998, ENST00000375921, 
ENST00000375922, ENST00000375934, 
ENST00000375938, ENST00000535842, 
Fusion gene scores* DoF score4 X 4 X 2=3214 X 11 X 7=1078
# samples 416
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(16/1078*10)=-2.75221336786514
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TTLL9 [Title/Abstract] AND CTNNB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTTLL9(30469688)-CTNNB1(41281414), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCTNNB1

GO:0000209

protein polyubiquitination

29374064

TgeneCTNNB1

GO:0008285

negative regulation of cell proliferation

12970740

TgeneCTNNB1

GO:0030997

regulation of centriole-centriole cohesion

18086858

TgeneCTNNB1

GO:0032355

response to estradiol

15304487

TgeneCTNNB1

GO:0033234

negative regulation of protein sumoylation

22155184

TgeneCTNNB1

GO:0043065

positive regulation of apoptotic process

12651860|12970740

TgeneCTNNB1

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

29374064

TgeneCTNNB1

GO:0043525

positive regulation of neuron apoptotic process

19591802

TgeneCTNNB1

GO:0045893

positive regulation of transcription, DNA-templated

12970740|18787224

TgeneCTNNB1

GO:0045944

positive regulation of transcription by RNA polymerase II

9065402|11751639|12651860|14660579|18193033

TgeneCTNNB1

GO:0060070

canonical Wnt signaling pathway

10644691|12937339|19187541

TgeneCTNNB1

GO:0071681

cellular response to indole-3-methanol

10868478

TgeneCTNNB1

GO:0090279

regulation of calcium ion import

19996314

TgeneCTNNB1

GO:1904798

positive regulation of core promoter binding

22723415

TgeneCTNNB1

GO:2000008

regulation of protein localization to cell surface

19996314



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADB360697TTLL9chr20

30469688

+CTNNB1chr3

41281414

-


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Fusion Gene ORF analysis for TTLL9-CTNNB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000310998ENST00000349496TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-3UTRENST00000310998ENST00000396183TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-3UTRENST00000310998ENST00000396185TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-3UTRENST00000375921ENST00000349496TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-3UTRENST00000375921ENST00000396183TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-3UTRENST00000375921ENST00000396185TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-3UTRENST00000375922ENST00000349496TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-3UTRENST00000375922ENST00000396183TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-3UTRENST00000375922ENST00000396185TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-3UTRENST00000375934ENST00000349496TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-3UTRENST00000375934ENST00000396183TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-3UTRENST00000375934ENST00000396185TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-3UTRENST00000375938ENST00000349496TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-3UTRENST00000375938ENST00000396183TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-3UTRENST00000375938ENST00000396185TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-3UTRENST00000535842ENST00000349496TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-3UTRENST00000535842ENST00000396183TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-3UTRENST00000535842ENST00000396185TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-intronENST00000310998ENST00000405570TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-intronENST00000310998ENST00000453024TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-intronENST00000310998ENST00000471014TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-intronENST00000375921ENST00000405570TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-intronENST00000375921ENST00000453024TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-intronENST00000375921ENST00000471014TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-intronENST00000375922ENST00000405570TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-intronENST00000375922ENST00000453024TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-intronENST00000375922ENST00000471014TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-intronENST00000375934ENST00000405570TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-intronENST00000375934ENST00000453024TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-intronENST00000375934ENST00000471014TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-intronENST00000375938ENST00000405570TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-intronENST00000375938ENST00000453024TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-intronENST00000375938ENST00000471014TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-intronENST00000535842ENST00000405570TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-intronENST00000535842ENST00000453024TTLL9chr20

30469688

+CTNNB1chr3

41281414

-
intron-intronENST00000535842ENST00000471014TTLL9chr20

30469688

+CTNNB1chr3

41281414

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TTLL9-CTNNB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for TTLL9-CTNNB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:30469688/:41281414)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TTLL9-CTNNB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TTLL9-CTNNB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TTLL9-CTNNB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TTLL9-CTNNB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTTLL9C0023903Liver neoplasms1CTD_human
HgeneTTLL9C0032460Polycystic Ovary Syndrome1CTD_human
HgeneTTLL9C0032927Precancerous Conditions1CTD_human
HgeneTTLL9C0282313Condition, Preneoplastic1CTD_human
HgeneTTLL9C0345904Malignant neoplasm of liver1CTD_human
HgeneTTLL9C1136382Sclerocystic Ovaries1CTD_human
HgeneTTLL9C3495676Anorectal Malformations1GENOMICS_ENGLAND
TgeneC0007102Malignant tumor of colon9CTD_human
TgeneC0009375Colonic Neoplasms9CTD_human
TgeneC3554449MENTAL RETARDATION, AUTOSOMAL DOMINANT 196CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0009402Colorectal Carcinoma5CTD_human;UNIPROT
TgeneC2239176Liver carcinoma5CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0009404Colorectal Neoplasms4CTD_human
TgeneC0001418Adenocarcinoma3CTD_human
TgeneC0019207Hepatoma, Morris3CTD_human
TgeneC0019208Hepatoma, Novikoff3CTD_human
TgeneC0023904Liver Neoplasms, Experimental3CTD_human
TgeneC0086404Experimental Hepatoma3CTD_human
TgeneC0205641Adenocarcinoma, Basal Cell3CTD_human
TgeneC0205642Adenocarcinoma, Oxyphilic3CTD_human
TgeneC0205643Carcinoma, Cribriform3CTD_human
TgeneC0205644Carcinoma, Granular Cell3CTD_human
TgeneC0205645Adenocarcinoma, Tubular3CTD_human
TgeneC0206711Pilomatrixoma3CTD_human;ORPHANET;UNIPROT
TgeneC1879526Aberrant Crypt Foci3CTD_human
TgeneC0001430Adenoma2CTD_human
TgeneC0006142Malignant neoplasm of breast2CTD_human
TgeneC0023903Liver neoplasms2CTD_human
TgeneC0025149Medulloblastoma2CGI;CTD_human;UNIPROT
TgeneC0027626Neoplasm Invasiveness2CTD_human
TgeneC0027708Nephroblastoma2CTD_human
TgeneC0033578Prostatic Neoplasms2CTD_human
TgeneC0036341Schizophrenia2PSYGENET
TgeneC0205646Adenoma, Basal Cell2CTD_human
TgeneC0205647Follicular adenoma2CTD_human
TgeneC0205648Adenoma, Microcystic2CTD_human
TgeneC0205649Adenoma, Monomorphic2CTD_human
TgeneC0205650Papillary adenoma2CTD_human
TgeneC0205651Adenoma, Trabecular2CTD_human
TgeneC0235874Disease Exacerbation2CTD_human
TgeneC0345904Malignant neoplasm of liver2CTD_human
TgeneC0376358Malignant neoplasm of prostate2CTD_human
TgeneC0678222Breast Carcinoma2CTD_human
TgeneC1140680Malignant neoplasm of ovary2CGI;CTD_human;UNIPROT
TgeneC1257931Mammary Neoplasms, Human2CTD_human
TgeneC1458155Mammary Neoplasms2CTD_human
TgeneC2930471Bilateral Wilms Tumor2CTD_human
TgeneC4539767EXUDATIVE VITREORETINOPATHY 72GENOMICS_ENGLAND;UNIPROT
TgeneC4704874Mammary Carcinoma, Human2CTD_human
TgeneC0000772Multiple congenital anomalies1CTD_human
TgeneC0001624Adrenal Gland Neoplasms1CTD_human
TgeneC0007193Cardiomyopathy, Dilated1CTD_human
TgeneC0007528Cecal Neoplasms1CTD_human
TgeneC0007621Neoplastic Cell Transformation1CTD_human
TgeneC0007873Uterine Cervical Neoplasm1CTD_human
TgeneC0010276Craniopharyngioma1CTD_human;ORPHANET
TgeneC0014518Toxic Epidermal Necrolysis1CTD_human
TgeneC0016059Fibrosis1CTD_human
TgeneC0018923Hemangiosarcoma1CTD_human
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0021841Intestinal Neoplasms1CTD_human
TgeneC0023890Liver Cirrhosis1CTD_human
TgeneC0024121Lung Neoplasms1CTD_human
TgeneC0026846Muscular Atrophy1CTD_human
TgeneC0027627Neoplasm Metastasis1CTD_human
TgeneC0027746Nerve Degeneration1CTD_human
TgeneC0030297Pancreatic Neoplasm1CTD_human
TgeneC0031149Peritoneal Neoplasms1CTD_human
TgeneC0038325Stevens-Johnson Syndrome1CTD_human
TgeneC0149721Left Ventricular Hypertrophy1CTD_human
TgeneC0151744Myocardial Ischemia1CTD_human
TgeneC0153437Malignant neoplasm of cecum1CTD_human
TgeneC0206624Hepatoblastoma1CGI;CTD_human
TgeneC0206669Hepatocellular Adenoma1CTD_human
TgeneC0206686Adrenocortical carcinoma1CTD_human
TgeneC0232347No-Reflow Phenomenon1CTD_human
TgeneC0239946Fibrosis, Liver1CTD_human
TgeneC0242379Malignant neoplasm of lung1CTD_human
TgeneC0242698Ventricular Dysfunction, Left1CTD_human
TgeneC0270948Neurogenic Muscular Atrophy1CTD_human
TgeneC0278875Adult Craniopharyngioma1CTD_human
TgeneC0279606Childhood Hepatocellular Carcinoma1ORPHANET
TgeneC0279607Adult Hepatocellular Carcinoma1ORPHANET
TgeneC0334634Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse1CTD_human
TgeneC0339539Familial Exudative Vitreoretinopathy1ORPHANET
TgeneC0342649Vascular calcification1CTD_human
TgeneC0345967Malignant mesothelioma1CTD_human
TgeneC0346627Intestinal Cancer1CTD_human
TgeneC0346647Malignant neoplasm of pancreas1CTD_human
TgeneC0346990Carcinomatosis of peritoneal cavity1CTD_human
TgeneC0376634Craniofacial Abnormalities1CTD_human
TgeneC0431128Papillary craniopharyngioma1CTD_human
TgeneC0431129Adamantinous Craniopharyngioma1CTD_human
TgeneC0431350Primary microcephaly1GENOMICS_ENGLAND
TgeneC0600519Ventricular Remodeling1CTD_human
TgeneC0600520Left Ventricle Remodeling1CTD_human
TgeneC0750887Adrenal Cancer1CTD_human
TgeneC0751061Craniopharyngioma, Child1CTD_human
TgeneC0751958Lymphoma, Lymphocytic, Intermediate1CTD_human
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC0919267ovarian neoplasm1CGI;CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC1274933Drug-Induced Stevens Johnson Syndrome1CTD_human
TgeneC1449563Cardiomyopathy, Familial Idiopathic1CTD_human
TgeneC1535926Neurodevelopmental Disorders1CTD_human
TgeneC1623038Cirrhosis1CTD_human
TgeneC1851402Exudative vitreoretinopathy 11ORPHANET
TgeneC2713615Slow-Flow Phenomenon1CTD_human
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC3658301Mycoplasma-Induced Stevens-Johnson Syndrome1CTD_human
TgeneC3658302Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum1CTD_human
TgeneC4048328cervical cancer1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human