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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DDX1-C3orf67 (FusionGDB2 ID:HG1653TG200844)

Fusion Gene Summary for DDX1-C3orf67

check button Fusion gene summary
Fusion gene informationFusion gene name: DDX1-C3orf67
Fusion gene ID: hg1653tg200844
HgeneTgene
Gene symbol

DDX1

C3orf67

Gene ID

1653

200844

Gene nameDEAD-box helicase 1CFAP20 domain containing
SynonymsDBP-RB|UKVH5dC3orf67
Cytomap('DDX1')('C3orf67')

2p24.3

3p14.2

Type of geneprotein-codingprotein-coding
DescriptionATP-dependent RNA helicase DDX1DEAD (Asp-Glu-Ala-Asp) box helicase 1DEAD (Asp-Glu-Ala-Asp) box polypeptide 1DEAD box polypeptide 1DEAD box protein 1DEAD box protein retinoblastomaDEAD box-1DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1DEAD/H-box huncharacterized protein C3orf67
Modification date2020031320200313
UniProtAcc

Q92499

.
Ensembl transtripts involved in fusion geneENST00000233084, ENST00000381341, 
Fusion gene scores* DoF score3 X 3 X 2=186 X 4 X 6=144
# samples 37
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DDX1 [Title/Abstract] AND C3orf67 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDDX1(15736887)-C3orf67(58792182), # samples:1
Anticipated loss of major functional domain due to fusion event.DDX1-C3orf67 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX1-C3orf67 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDDX1

GO:0006302

double-strand break repair

18710941

HgeneDDX1

GO:0032508

DNA duplex unwinding

18710941

HgeneDDX1

GO:0090305

nucleic acid phosphodiester bond hydrolysis

18710941


check buttonFusion gene breakpoints across DDX1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across C3orf67 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-5441-01ADDX1chr2

15736887

+C3orf67chr3

58792182

-


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Fusion Gene ORF analysis for DDX1-C3orf67

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000233084ENST00000472469DDX1chr2

15736887

+C3orf67chr3

58792182

-
5CDS-intronENST00000233084ENST00000478363DDX1chr2

15736887

+C3orf67chr3

58792182

-
5CDS-intronENST00000233084ENST00000491845DDX1chr2

15736887

+C3orf67chr3

58792182

-
5CDS-intronENST00000381341ENST00000472469DDX1chr2

15736887

+C3orf67chr3

58792182

-
5CDS-intronENST00000381341ENST00000478363DDX1chr2

15736887

+C3orf67chr3

58792182

-
5CDS-intronENST00000381341ENST00000491845DDX1chr2

15736887

+C3orf67chr3

58792182

-
In-frameENST00000233084ENST00000295966DDX1chr2

15736887

+C3orf67chr3

58792182

-
In-frameENST00000233084ENST00000482387DDX1chr2

15736887

+C3orf67chr3

58792182

-
In-frameENST00000381341ENST00000295966DDX1chr2

15736887

+C3orf67chr3

58792182

-
In-frameENST00000381341ENST00000482387DDX1chr2

15736887

+C3orf67chr3

58792182

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000381341DDX1chr215736887+ENST00000295966C3orf67chr358792182-1275551389820143
ENST00000381341DDX1chr215736887+ENST00000482387C3orf67chr358792182-1271551389820143
ENST00000233084DDX1chr215736887+ENST00000295966C3orf67chr358792182-1174450288719143
ENST00000233084DDX1chr215736887+ENST00000482387C3orf67chr358792182-1170450288719143

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000381341ENST00000295966DDX1chr215736887+C3orf67chr358792182-0.0042605140.99573946
ENST00000381341ENST00000482387DDX1chr215736887+C3orf67chr358792182-0.0040568070.9959431
ENST00000233084ENST00000295966DDX1chr215736887+C3orf67chr358792182-0.0024927490.9975073
ENST00000233084ENST00000482387DDX1chr215736887+C3orf67chr358792182-0.0024786620.99752134

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Fusion Genomic Features for DDX1-C3orf67


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DDX1-C3orf67


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:15736887/chr3:58792182)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDX1

Q92499

.
FUNCTION: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}.; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX1chr2:15736887chr3:58792182ENST00000233084+42646_5354741.0Nucleotide bindingATP
HgeneDDX1chr2:15736887chr3:58792182ENST00000381341+52746_5354741.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX1chr2:15736887chr3:58792182ENST00000233084+4262_42854741.0DomainHelicase ATP-binding
HgeneDDX1chr2:15736887chr3:58792182ENST00000233084+426493_68154741.0DomainHelicase C-terminal
HgeneDDX1chr2:15736887chr3:58792182ENST00000233084+42670_24754741.0DomainB30.2/SPRY
HgeneDDX1chr2:15736887chr3:58792182ENST00000381341+5272_42854741.0DomainHelicase ATP-binding
HgeneDDX1chr2:15736887chr3:58792182ENST00000381341+527493_68154741.0DomainHelicase C-terminal
HgeneDDX1chr2:15736887chr3:58792182ENST00000381341+52770_24754741.0DomainB30.2/SPRY
HgeneDDX1chr2:15736887chr3:58792182ENST00000233084+426370_37354741.0MotifDEAD box
HgeneDDX1chr2:15736887chr3:58792182ENST00000381341+527370_37354741.0MotifDEAD box


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Fusion Gene Sequence for DDX1-C3orf67


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21923_21923_1_DDX1-C3orf67_DDX1_chr2_15736887_ENST00000233084_C3orf67_chr3_58792182_ENST00000295966_length(transcript)=1174nt_BP=450nt
CTCTGTAGCTGTGACCCTGATACCGCGTGGTGTGCTCCGAACACATGGTGCCCAGAACGAAGGCGGCGTCCAGAAGCCCTAGGTCCCAGA
GGTCCGCTCAGCGGCAGGCGCATAAGGCGGGGCCGGCGCGGGCCTTTCCTTCCATCGGAACCGTTCTCCCGGGGCTGAGTCCCTGCCCGG
ACTCCGAACGCCGAAGACCAGGGGCCGGAAGCGCGCGCCGCCACTGCCACGCCGTGTCAGTCGGGAGGGAGGGAGCGAGCAGGCGAAGCC
GCGGAGGACGGGGTGAAGATGGCGGCCTTCTCCGAGATGGGTGTAATGCCTGAGATTGCACAAGCTGTGGAAGAGATGGATTGGCTCCTC
CCAACTGATATCCAGGCTGAATCTATCCCATTGATCTTAGGAGGAGGTGATGTACTTATGGCTGCAGAAACAGGAAGTGGCAAAACTGGT
CCTGTCAACCAGGGTCGCCACTATCAGAAAGAAATGAACCCACCTTCTCCTTCTAATCCCCGGGACTGGTTAAATATGTTGAGCCCACCA
ATCGTTCCTCCCAGTCAACAGCCGGCTGAGCAGCGTCCAGATTCCTGTGAAAGTTTGAGTGTTCAAGGTGAAGAAGACCTCAGTGTGGAA
GAGGACGAGGAAGTACTGACTTTGTTGTATGACCCTTGTCTGAACTGTTACTTTGACCCCCAAACAGGGAAATACTATGAGTTGGTATAA
TGCCTCCTTCCGGGGCAGAGAGCAGGCACTCCCAGCTGGAGCAGAATAGCAGTTCAGGGTCGCTTAAGGAGTCACCACAACTTATGTGTT
GGGTGACCACAAAATCAACAGTAACTGAGAGAAACGAATTCATTTTGTAAATAATGTTCAACGTTAAGAATACCTATATTCCTTTTGTAG
ATGAGTATGATTTTGAAACTGAAGAAATTAATACAGAGGCAAGATTTTAGGAGTTTGAATTGGTTCTTGTTTGTTCTCATTCTACATATA
ATTTTGTTTATTTCAGATAATTTTATGTAAACAAATTAAGAGTTATTCATTCAAATTTTTTGCAGTGTTAATCTGTAAATGATGGCTTGA
TGTACAGAAAATGTATTTTTGCTTAAAAGATGCCTGGGTACCTTTTATTTTATGGCATTTGTATTAAAAATAAAGTATGATGGTAAGAAG

>21923_21923_1_DDX1-C3orf67_DDX1_chr2_15736887_ENST00000233084_C3orf67_chr3_58792182_ENST00000295966_length(amino acids)=143AA_BP=54
MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGPVNQGRHYQKEMNPPSPSNPRDWLNMLSPPIVPPSQ

--------------------------------------------------------------
>21923_21923_2_DDX1-C3orf67_DDX1_chr2_15736887_ENST00000233084_C3orf67_chr3_58792182_ENST00000482387_length(transcript)=1170nt_BP=450nt
CTCTGTAGCTGTGACCCTGATACCGCGTGGTGTGCTCCGAACACATGGTGCCCAGAACGAAGGCGGCGTCCAGAAGCCCTAGGTCCCAGA
GGTCCGCTCAGCGGCAGGCGCATAAGGCGGGGCCGGCGCGGGCCTTTCCTTCCATCGGAACCGTTCTCCCGGGGCTGAGTCCCTGCCCGG
ACTCCGAACGCCGAAGACCAGGGGCCGGAAGCGCGCGCCGCCACTGCCACGCCGTGTCAGTCGGGAGGGAGGGAGCGAGCAGGCGAAGCC
GCGGAGGACGGGGTGAAGATGGCGGCCTTCTCCGAGATGGGTGTAATGCCTGAGATTGCACAAGCTGTGGAAGAGATGGATTGGCTCCTC
CCAACTGATATCCAGGCTGAATCTATCCCATTGATCTTAGGAGGAGGTGATGTACTTATGGCTGCAGAAACAGGAAGTGGCAAAACTGGT
CCTGTCAACCAGGGTCGCCACTATCAGAAAGAAATGAACCCACCTTCTCCTTCTAATCCCCGGGACTGGTTAAATATGTTGAGCCCACCA
ATCGTTCCTCCCAGTCAACAGCCGGCTGAGCAGCGTCCAGATTCCTGTGAAAGTTTGAGTGTTCAAGGTGAAGAAGACCTCAGTGTGGAA
GAGGACGAGGAAGTACTGACTTTGTTGTATGACCCTTGTCTGAACTGTTACTTTGACCCCCAAACAGGGAAATACTATGAGTTGGTATAA
TGCCTCCTTCCGGGGCAGAGAGCAGGCACTCCCAGCTGGAGCAGAATAGCAGTTCAGGGTCGCTTAAGGAGTCACCACAACTTATGTGTT
GGGTGACCACAAAATCAACAGTAACTGAGAGAAACGAATTCATTTTGTAAATAATGTTCAACGTTAAGAATACCTATATTCCTTTTGTAG
ATGAGTATGATTTTGAAACTGAAGAAATTAATACAGAGGCAAGATTTTAGGAGTTTGAATTGGTTCTTGTTTGTTCTCATTCTACATATA
ATTTTGTTTATTTCAGATAATTTTATGTAAACAAATTAAGAGTTATTCATTCAAATTTTTTGCAGTGTTAATCTGTAAATGATGGCTTGA
TGTACAGAAAATGTATTTTTGCTTAAAAGATGCCTGGGTACCTTTTATTTTATGGCATTTGTATTAAAAATAAAGTATGATGGTAAGAAG

>21923_21923_2_DDX1-C3orf67_DDX1_chr2_15736887_ENST00000233084_C3orf67_chr3_58792182_ENST00000482387_length(amino acids)=143AA_BP=54
MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGPVNQGRHYQKEMNPPSPSNPRDWLNMLSPPIVPPSQ

--------------------------------------------------------------
>21923_21923_3_DDX1-C3orf67_DDX1_chr2_15736887_ENST00000381341_C3orf67_chr3_58792182_ENST00000295966_length(transcript)=1275nt_BP=551nt
GGCTCAGATCCCACGCTGCCATTCGGTAGATATGTGTCTTTAGATAAGTGACTTAACTTTCCCGAATTTTAGAGTCCTCATCTAAAGATT
CTAATACCTTCCTGACAGACTGTGACCCTGATACCGCGTGGTGTGCTCCGAACACATGGTGCCCAGAACGAAGGCGGCGTCCAGAAGCCC
TAGGTCCCAGAGGTCCGCTCAGCGGCAGGCGCATAAGGCGGGGCCGGCGCGGGCCTTTCCTTCCATCGGAACCGTTCTCCCGGGGCTGAG
TCCCTGCCCGGACTCCGAACGCCGAAGACCAGGGGCCGGAAGCGCGCGCCGCCACTGCCACGCCGTGTCAGTCGGGAGGGAGGGAGCGAG
CAGGCGAAGCCGCGGAGGACGGGGTGAAGATGGCGGCCTTCTCCGAGATGGGTGTAATGCCTGAGATTGCACAAGCTGTGGAAGAGATGG
ATTGGCTCCTCCCAACTGATATCCAGGCTGAATCTATCCCATTGATCTTAGGAGGAGGTGATGTACTTATGGCTGCAGAAACAGGAAGTG
GCAAAACTGGTCCTGTCAACCAGGGTCGCCACTATCAGAAAGAAATGAACCCACCTTCTCCTTCTAATCCCCGGGACTGGTTAAATATGT
TGAGCCCACCAATCGTTCCTCCCAGTCAACAGCCGGCTGAGCAGCGTCCAGATTCCTGTGAAAGTTTGAGTGTTCAAGGTGAAGAAGACC
TCAGTGTGGAAGAGGACGAGGAAGTACTGACTTTGTTGTATGACCCTTGTCTGAACTGTTACTTTGACCCCCAAACAGGGAAATACTATG
AGTTGGTATAATGCCTCCTTCCGGGGCAGAGAGCAGGCACTCCCAGCTGGAGCAGAATAGCAGTTCAGGGTCGCTTAAGGAGTCACCACA
ACTTATGTGTTGGGTGACCACAAAATCAACAGTAACTGAGAGAAACGAATTCATTTTGTAAATAATGTTCAACGTTAAGAATACCTATAT
TCCTTTTGTAGATGAGTATGATTTTGAAACTGAAGAAATTAATACAGAGGCAAGATTTTAGGAGTTTGAATTGGTTCTTGTTTGTTCTCA
TTCTACATATAATTTTGTTTATTTCAGATAATTTTATGTAAACAAATTAAGAGTTATTCATTCAAATTTTTTGCAGTGTTAATCTGTAAA
TGATGGCTTGATGTACAGAAAATGTATTTTTGCTTAAAAGATGCCTGGGTACCTTTTATTTTATGGCATTTGTATTAAAAATAAAGTATG

>21923_21923_3_DDX1-C3orf67_DDX1_chr2_15736887_ENST00000381341_C3orf67_chr3_58792182_ENST00000295966_length(amino acids)=143AA_BP=54
MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGPVNQGRHYQKEMNPPSPSNPRDWLNMLSPPIVPPSQ

--------------------------------------------------------------
>21923_21923_4_DDX1-C3orf67_DDX1_chr2_15736887_ENST00000381341_C3orf67_chr3_58792182_ENST00000482387_length(transcript)=1271nt_BP=551nt
GGCTCAGATCCCACGCTGCCATTCGGTAGATATGTGTCTTTAGATAAGTGACTTAACTTTCCCGAATTTTAGAGTCCTCATCTAAAGATT
CTAATACCTTCCTGACAGACTGTGACCCTGATACCGCGTGGTGTGCTCCGAACACATGGTGCCCAGAACGAAGGCGGCGTCCAGAAGCCC
TAGGTCCCAGAGGTCCGCTCAGCGGCAGGCGCATAAGGCGGGGCCGGCGCGGGCCTTTCCTTCCATCGGAACCGTTCTCCCGGGGCTGAG
TCCCTGCCCGGACTCCGAACGCCGAAGACCAGGGGCCGGAAGCGCGCGCCGCCACTGCCACGCCGTGTCAGTCGGGAGGGAGGGAGCGAG
CAGGCGAAGCCGCGGAGGACGGGGTGAAGATGGCGGCCTTCTCCGAGATGGGTGTAATGCCTGAGATTGCACAAGCTGTGGAAGAGATGG
ATTGGCTCCTCCCAACTGATATCCAGGCTGAATCTATCCCATTGATCTTAGGAGGAGGTGATGTACTTATGGCTGCAGAAACAGGAAGTG
GCAAAACTGGTCCTGTCAACCAGGGTCGCCACTATCAGAAAGAAATGAACCCACCTTCTCCTTCTAATCCCCGGGACTGGTTAAATATGT
TGAGCCCACCAATCGTTCCTCCCAGTCAACAGCCGGCTGAGCAGCGTCCAGATTCCTGTGAAAGTTTGAGTGTTCAAGGTGAAGAAGACC
TCAGTGTGGAAGAGGACGAGGAAGTACTGACTTTGTTGTATGACCCTTGTCTGAACTGTTACTTTGACCCCCAAACAGGGAAATACTATG
AGTTGGTATAATGCCTCCTTCCGGGGCAGAGAGCAGGCACTCCCAGCTGGAGCAGAATAGCAGTTCAGGGTCGCTTAAGGAGTCACCACA
ACTTATGTGTTGGGTGACCACAAAATCAACAGTAACTGAGAGAAACGAATTCATTTTGTAAATAATGTTCAACGTTAAGAATACCTATAT
TCCTTTTGTAGATGAGTATGATTTTGAAACTGAAGAAATTAATACAGAGGCAAGATTTTAGGAGTTTGAATTGGTTCTTGTTTGTTCTCA
TTCTACATATAATTTTGTTTATTTCAGATAATTTTATGTAAACAAATTAAGAGTTATTCATTCAAATTTTTTGCAGTGTTAATCTGTAAA
TGATGGCTTGATGTACAGAAAATGTATTTTTGCTTAAAAGATGCCTGGGTACCTTTTATTTTATGGCATTTGTATTAAAAATAAAGTATG

>21923_21923_4_DDX1-C3orf67_DDX1_chr2_15736887_ENST00000381341_C3orf67_chr3_58792182_ENST00000482387_length(amino acids)=143AA_BP=54
MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGPVNQGRHYQKEMNPPSPSNPRDWLNMLSPPIVPPSQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DDX1-C3orf67


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDDX1chr2:15736887chr3:58792182ENST00000233084+4261_44854.0741.0dsRNA
HgeneDDX1chr2:15736887chr3:58792182ENST00000381341+5271_44854.0741.0dsRNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DDX1-C3orf67


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DDX1-C3orf67


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDDX1C0013146Drug abuse1CTD_human
HgeneDDX1C0013170Drug habituation1CTD_human
HgeneDDX1C0013222Drug Use Disorders1CTD_human
HgeneDDX1C0014173Endometrial Hyperplasia1CTD_human
HgeneDDX1C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneDDX1C0038580Substance Dependence1CTD_human
HgeneDDX1C0038586Substance Use Disorders1CTD_human
HgeneDDX1C0236969Substance-Related Disorders1CTD_human
HgeneDDX1C0349578Complex Endometrial Hyperplasia1CTD_human
HgeneDDX1C0349579Atypical Endometrial Hyperplasia1CTD_human
HgeneDDX1C0456483Simple Endometrial Hyperplasia1CTD_human
HgeneDDX1C0740858Substance abuse problem1CTD_human
HgeneDDX1C1510472Drug Dependence1CTD_human
HgeneDDX1C4316881Prescription Drug Abuse1CTD_human