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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DHX9-XPR1 (FusionGDB2 ID:HG1660TG9213)

Fusion Gene Summary for DHX9-XPR1

check button Fusion gene summary
Fusion gene informationFusion gene name: DHX9-XPR1
Fusion gene ID: hg1660tg9213
HgeneTgene
Gene symbol

DHX9

XPR1

Gene ID

1660

9213

Gene nameDExH-box helicase 9xenotropic and polytropic retrovirus receptor 1
SynonymsDDX9|LKP|NDH2|NDHII|RHAIBGC6|SLC53A1|SYG1|X3
Cytomap('DHX9')('XPR1')

1q25.3

1q25.3

Type of geneprotein-codingprotein-coding
DescriptionATP-dependent RNA helicase ADEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9DEAH (Asp-Glu-Ala-His) box helicase 9DEAH (Asp-Glu-Ala-His) box polypeptide 9DEAH box protein 9DEAH-box helicase 9RNA helicase Aleukophysinnuclear DNA helicase IIxenotropic and polytropic retrovirus receptor 1X-receptorprotein SYG1 homologsolute carrier family 53 (phosphate exporter), member 1xenotropic and polytropic murine leukemia virus receptor X3
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000367549, ENST00000485081, 
Fusion gene scores* DoF score14 X 10 X 7=9808 X 9 X 5=360
# samples 159
** MAII scorelog2(15/980*10)=-2.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DHX9 [Title/Abstract] AND XPR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDHX9(182829319)-XPR1(180651495), # samples:2
Anticipated loss of major functional domain due to fusion event.DHX9-XPR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DHX9-XPR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DHX9-XPR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DHX9-XPR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDHX9

GO:0010501

RNA secondary structure unwinding

1537828|9111062

HgeneDHX9

GO:0032508

DNA duplex unwinding

9111062|21561811

HgeneDHX9

GO:0034622

cellular protein-containing complex assembly

23361462

HgeneDHX9

GO:0039695

DNA-templated viral transcription

11096080

HgeneDHX9

GO:0044806

G-quadruplex DNA unwinding

21561811

HgeneDHX9

GO:0046833

positive regulation of RNA export from nucleus

11402034

HgeneDHX9

GO:0050434

positive regulation of viral transcription

11096080

HgeneDHX9

GO:0050684

regulation of mRNA processing

28355180

HgeneDHX9

GO:2000765

regulation of cytoplasmic translation

28355180


check buttonFusion gene breakpoints across DHX9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across XPR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-VR-A8EWDHX9chr1

182829319

+XPR1chr1

180651495

+


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Fusion Gene ORF analysis for DHX9-XPR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000367549ENST00000467345DHX9chr1

182829319

+XPR1chr1

180651495

+
In-frameENST00000367549ENST00000367589DHX9chr1

182829319

+XPR1chr1

180651495

+
In-frameENST00000367549ENST00000367590DHX9chr1

182829319

+XPR1chr1

180651495

+
intron-3CDSENST00000485081ENST00000367589DHX9chr1

182829319

+XPR1chr1

180651495

+
intron-3CDSENST00000485081ENST00000367590DHX9chr1

182829319

+XPR1chr1

180651495

+
intron-intronENST00000485081ENST00000467345DHX9chr1

182829319

+XPR1chr1

180651495

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367549DHX9chr1182829319+ENST00000367590XPR1chr1180651495+9649144211034631117
ENST00000367549DHX9chr1182829319+ENST00000367589XPR1chr1180651495+5329144211032681052

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367549ENST00000367590DHX9chr1182829319+XPR1chr1180651495+9.56E-050.9999044
ENST00000367549ENST00000367589DHX9chr1182829319+XPR1chr1180651495+0.0002366560.9997633

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Fusion Genomic Features for DHX9-XPR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DHX9chr1182829319+XPR1chr1180651495+7.09E-101
DHX9chr1182829319+XPR1chr1180651495+7.09E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DHX9-XPR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:182829319/chr1:180651495)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+1228180_2524441271.0DomainDRBM 2
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+12283_714441271.0DomainDRBM 1
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+1228411_4194441271.0Nucleotide bindingATP
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+1228182_1864441271.0RegionsiRNA-binding
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+1228234_2364441271.0RegionsiRNA-binding
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+1228331_3804441271.0RegionMTAD
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+122853_554441271.0RegionsiRNA-binding
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+12285_94441271.0RegionsiRNA-binding
TgeneXPR1chr1:182829319chr1:180651495ENST00000367589014439_64323632.0DomainEXS
TgeneXPR1chr1:182829319chr1:180651495ENST00000367590015439_64323697.0DomainEXS
TgeneXPR1chr1:182829319chr1:180651495ENST00000367589014158_16523632.0RegionImportant for inositol polyphosphate binding
TgeneXPR1chr1:182829319chr1:180651495ENST00000367590015158_16523697.0RegionImportant for inositol polyphosphate binding
TgeneXPR1chr1:182829319chr1:180651495ENST00000367589014258_26423632.0Topological domainExtracellular
TgeneXPR1chr1:182829319chr1:180651495ENST00000367589014286_31823632.0Topological domainCytoplasmic
TgeneXPR1chr1:182829319chr1:180651495ENST00000367589014340_34523632.0Topological domainExtracellular
TgeneXPR1chr1:182829319chr1:180651495ENST00000367589014369_37623632.0Topological domainCytoplasmic
TgeneXPR1chr1:182829319chr1:180651495ENST00000367589014398_40223632.0Topological domainExtracellular
TgeneXPR1chr1:182829319chr1:180651495ENST00000367589014424_47323632.0Topological domainCytoplasmic
TgeneXPR1chr1:182829319chr1:180651495ENST00000367589014497_50723632.0Topological domainExtracellular
TgeneXPR1chr1:182829319chr1:180651495ENST00000367589014529_69623632.0Topological domainCytoplasmic
TgeneXPR1chr1:182829319chr1:180651495ENST00000367590015258_26423697.0Topological domainExtracellular
TgeneXPR1chr1:182829319chr1:180651495ENST00000367590015286_31823697.0Topological domainCytoplasmic
TgeneXPR1chr1:182829319chr1:180651495ENST00000367590015340_34523697.0Topological domainExtracellular
TgeneXPR1chr1:182829319chr1:180651495ENST00000367590015369_37623697.0Topological domainCytoplasmic
TgeneXPR1chr1:182829319chr1:180651495ENST00000367590015398_40223697.0Topological domainExtracellular
TgeneXPR1chr1:182829319chr1:180651495ENST00000367590015424_47323697.0Topological domainCytoplasmic
TgeneXPR1chr1:182829319chr1:180651495ENST00000367590015497_50723697.0Topological domainExtracellular
TgeneXPR1chr1:182829319chr1:180651495ENST00000367590015529_69623697.0Topological domainCytoplasmic
TgeneXPR1chr1:182829319chr1:180651495ENST00000367589014237_25723632.0TransmembraneHelical
TgeneXPR1chr1:182829319chr1:180651495ENST00000367589014265_28523632.0TransmembraneHelical
TgeneXPR1chr1:182829319chr1:180651495ENST00000367589014319_33923632.0TransmembraneHelical
TgeneXPR1chr1:182829319chr1:180651495ENST00000367589014346_36823632.0TransmembraneHelical
TgeneXPR1chr1:182829319chr1:180651495ENST00000367589014377_39723632.0TransmembraneHelical
TgeneXPR1chr1:182829319chr1:180651495ENST00000367589014403_42323632.0TransmembraneHelical
TgeneXPR1chr1:182829319chr1:180651495ENST00000367589014474_49623632.0TransmembraneHelical
TgeneXPR1chr1:182829319chr1:180651495ENST00000367589014508_52823632.0TransmembraneHelical
TgeneXPR1chr1:182829319chr1:180651495ENST00000367590015237_25723697.0TransmembraneHelical
TgeneXPR1chr1:182829319chr1:180651495ENST00000367590015265_28523697.0TransmembraneHelical
TgeneXPR1chr1:182829319chr1:180651495ENST00000367590015319_33923697.0TransmembraneHelical
TgeneXPR1chr1:182829319chr1:180651495ENST00000367590015346_36823697.0TransmembraneHelical
TgeneXPR1chr1:182829319chr1:180651495ENST00000367590015377_39723697.0TransmembraneHelical
TgeneXPR1chr1:182829319chr1:180651495ENST00000367590015403_42323697.0TransmembraneHelical
TgeneXPR1chr1:182829319chr1:180651495ENST00000367590015474_49623697.0TransmembraneHelical
TgeneXPR1chr1:182829319chr1:180651495ENST00000367590015508_52823697.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+1228398_5644441271.0DomainHelicase ATP-binding
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+1228636_8094441271.0DomainHelicase C-terminal
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+12281155_11734441271.0MotifNuclear localization signal (NLS2)
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+1228511_5144441271.0MotifNote=DEIH box
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+1228586_5954441271.0MotifNuclear localization signal (NLS1)
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+12281150_12704441271.0RegionRGG
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+1228398_8094441271.0RegionCore helicase
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+1228831_9194441271.0RegionHA2
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+1228958_10744441271.0RegionOB-fold
TgeneXPR1chr1:182829319chr1:180651495ENST000003675890141_17723632.0DomainSPX
TgeneXPR1chr1:182829319chr1:180651495ENST000003675900151_17723697.0DomainSPX
TgeneXPR1chr1:182829319chr1:180651495ENST000003675890141_23623632.0Topological domainCytoplasmic
TgeneXPR1chr1:182829319chr1:180651495ENST000003675900151_23623697.0Topological domainCytoplasmic


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Fusion Gene Sequence for DHX9-XPR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22735_22735_1_DHX9-XPR1_DHX9_chr1_182829319_ENST00000367549_XPR1_chr1_180651495_ENST00000367589_length(transcript)=5329nt_BP=1442nt
GCGAGTTGCTGTGCGTTTCTCTGTTGTCTCGGTAGAAGGCCAGAGTCACACACGGTCCTAAGAGCTGGGCACCAGGAAGCGAAGGCTGAT
CTGAAGAAGACACTTGAATCATGGGTGACGTTAAAAATTTTCTGTATGCCTGGTGTGGCAAAAGGAAGATGACCCCATCCTATGAAATTA
GAGCAGTGGGGAACAAAAACAGGCAGAAATTCATGTGTGAGGTTCAGGTGGAAGGTTATAATTACACTGGCATGGGAAATTCCACCAATA
AAAAAGATGCACAAAGCAATGCTGCCAGAGACTTTGTTAACTATTTGGTTCGAATAAATGAAATAAAGAGTGAAGAAGTTCCAGCTTTTG
GGGTAGCATCTCCGCCCCCACTTACTGATACTCCTGACACTACAGCAAATGCTGAAGGAGATTTACCAACAACCATGGGAGGACCTCTTC
CTCCACATCTGGCTCTCAAAGCAGAAAATAATTCTGAGGTAGGGGCCTCTGGCTATGGTGTTCCTGGGCCCACCTGGGACCGAGGAGCCA
ACTTGAAGGATTACTACTCAAGAAAGGAAGAACAAGAAGTGCAAGCGACTCTAGAATCAGAAGAAGTGGATTTAAATGCTGGGCTTCATG
GAAACTGGACCTTGGAAAATGCTAAAGCTCGTCTAAACCAATATTTTCAGAAAGAAAAGATCCAAGGAGAATATAAGTACACCCAAGTGG
GTCCTGATCACAACAGGAGCTTTATTGCAGAAATGACCATTTATATCAAGCAGCTGGGCAGAAGGATTTTTGCACGAGAACATGGATCAA
ATAAGAAATTGGCAGCACAGTCCTGTGCCCTGTCACTTGTCAGACAACTGTACCATCTTGGAGTGGTTGAAGCTTACTCCGGACTTACAA
AGAAGAAGGAAGGAGAGACAGTGGAGCCTTACAAAGTAAACCTCTCTCAAGATTTAGAGCATCAGCTGCAAAACATCATTCAAGAGCTAA
ATCTTGAGATTTTGCCCCCGCCTGAAGATCCTTCTGTGCCAGTTGCACTCAACATTGGCAAATTGGCTCAGTTCGAACCATCTCAGCGAC
AAAACCAAGTGGGTGTGGTTCCTTGGTCACCTCCACAATCCAACTGGAATCCTTGGACTAGTAGCAACATTGATGAGGGGCCTCTGGCTT
TTGCTACTCCAGAGCAAATAAGCATGGACCTCAAGAATGAATTGATGTACCAGTTGGAACAGGATCATGATTTGCAAGCAATCTTGCAGG
AGAGAGAGTTACTGCCTGTGAAGAAATTTGAAAGTGAGATTCTGGAAGCAATCAGCCAAAATTCAGTTGTCATTATTAGAGGGGCTACTG
GATGTGGGAAAACCACACAGGTTCCCCAGTTCATTCTAGATGACTTTATCCAGAATGACCGAGCAGCAGAGTGTAACATCGTAGTAACTC
AGGCTTTCAAGGATATGCTGTATTCAGCTCAGGACCAGGCACCTTCTGTGGAAGTTACAGATGAGGACACAGTAAAGAGGTATTTTGCCA
AGTTTGAAGAGAAGTTTTTCCAAACCTGTGAAAAAGAACTTGCCAAAATCAACACATTTTATTCAGAGAAGCTCGCAGAGGCTCAGCGCA
GGTTTGCTACACTTCAGAATGAGCTTCAGTCATCACTGGATGCACAGAAAGAAAGCACTGGTGTTACTACGCTGCGACAACGCAGAAAGC
CAGTCTTCCACTTGTCCCATGAGGAACGTGTCCAACATAGAAATATTAAAGACCTTAAACTGGCCTTCAGTGAGTTCTACCTCAGTCTAA
TCCTGCTGCAGAACTATCAGAATCTGAATTTTACAGGGTTTCGAAAAATCCTGAAAAAGCATGACAAGATCCTGGAAACATCTCGTGGAG
CAGATTGGCGAGTGGCTCACGTAGAGGTGGCCCCATTTTATACATGCAAGAAAATCAACCAGCTTATCTCTGAAACTGAGGCTGTAGTGA
CCAATGAACTTGAAGATGGTGACAGACAAAAGGCTATGAAGCGTTTACGTGTCCCCCCTTTGGGAGCTGCTCAGCCTGCACCAGCATGGA
CTACTTTTAGAGTTGGCCTATTTTGTGGAATATTCATTGTACTGAATATTACCCTTGTGCTTGCCGCTGTATTTAAACTTGAAACAGATA
GAAGTATATGGCCCTTGATAAGAATCTATCGGGGTGGCTTTCTTCTGATTGAATTCCTTTTTCTACTGGGCATCAACACGTATGGTTGGA
GACAGGCTGGAGTAAACCATGTACTCATCTTTGAACTTAATCCGAGAAGCAATTTGTCTCATCAACATCTCTTTGAGATTGCTGGATTCC
TCGGGATATTGTGGTGCCTGAGCCTTCTGGCATGCTTCTTTGCTCCAATTAGTGTCATCCCCACATATGTGTATCCACTTGCCCTTTATG
GATTTATGGTTTTCTTCCTTATCAACCCCACCAAAACTTTCTACTATAAATCCCGGTTTTGGCTGCTTAAACTGCTGTTTCGAGTATTTA
CAGCCCCCTTCCATAAGGTAGGCTTTGCTGATTTCTGGCTGGCGGATCAGCTGAACAGCCTGTCAGTGATACTGATGGACCTGGAATATA
TGATCTGCTTCTACAGTTTGGAGCTCAAATGGGATGAAAGTAAGGGCCTGTTGCCAAATAATTCAGAAGAACGAGGTCACTCGGACACTA
TGGTGTTCTTTTACCTGTGGATTGTCTTTTATATCATCAGTTCCTGCTATACCCTCATCTGGGATCTCAAGATGGACTGGGGTCTCTTCG
ATAAGAATGCTGGAGAGAACACTTTCCTCCGGGAAGAGATTGTATACCCCCAAAAAGCCTACTACTACTGTGCCATAATAGAGGATGTGA
TTCTGCGCTTTGCTTGGACTATCCAAATCTCGATTACCTCTACAACTTTGTTGCCTCATTCTGGGGACATCATTGCTACTGTCTTTGCCC
CACTTGAGGTTTTCCGGCGATTTGTGTGGAACTTCTTCCGCCTGGAGAATGAACATCTGAATAACTGTGGTGAATTCCGTGCTGTGCGGG
ACATCTCTGTGGCCCCCCTGAACGCAGATGATCAGACTCTCCTAGAACAGATGATGGACCAGGATGATGGGGTACGAAACCGCCAGAAGA
ATCGGTCATGGAAGTACAACCAGAGCATATCCCTGCGCCGGCCTCGCCTCGCTTCTCAATCCAAGGCTCGTGACACTAAGGTATTGATAG
AAGACACAGATGATGAAGCTAACACTTGAATTTTCTGAAGTCTAGCTTAACATCTTTGGTTTTCCTACTCTACAATCCTTTCCTCGACCA
ACGCAACCTCTAGTACCTTTCCAGCCGAAAACAGGAGAAAACACATAACACATTTTCCGAGCTCTTCCGGATCGGATCCTATGGACTCCA
AACAAGCTCACTGTGTTTCTTTTCTTTTCTTCTGGTTTAATTTTAATTTTCTATTTTCAAAACAAATATTTACTTCATTTGCCAATCAGA
GGATGTTTTAAGAAACAAAACATAGTATCTTATGGATTGTTTACAATCACAAGGACATAGATACCTATCAGGATGAAGAACAGGCATTGC
AAGGACCCTCTGATGGGACGGTACTGAGATATCTCGGCTTCCGCTCAGCCCGGTTTTGACTGGTTGAAACCGGACATTGGTTTTTAAATT
TTTTGTCAGTTTATGTGGAGAATTTTTTTCTTTCCTTCATACCCAGCGCAAAGGCACTGGCCGCACTTGCAGGAAAAGTGCAACTTAAAG
CAGTACCTTCATTCATGAAGCTACTTTTTAATTTGATGTAACTTTTCTTATTTTGGGAAGGGTTGCTGGGTGGGTGGGAAATATGATGTA
TTTGTTACACATAGTTTTCTCATTATTTATGAAACTTAACCATACAGAATGATATAACTCCTGTGCAATGAAGGTGATAACAGTAAAAGA
AGGCAGGGGAAACTTACGTTGGATGACATTTATGAGGGTCAGTCCCACATACCTCTTTCAGGAGACAACTTGCACCAGTTTGACCTTTTC
TTTTCTTTGTTTTTATTTTAAGCCAAAGTTTCATTGCTAACTTCTTAAGTTGCTGCTGCTTTAGAGTCCTGAGCATATCTCTCATAACAA
GGAATCCCACACTTCACACCACCGGCTGAATTTCATGGAAGAGGTTCTGATAATTTTTTTAACTTTTTAAGGAACAGATGTGGAATACAC
TGGCCCATATTTCAACCTTAACAGCTGAAGCTATGCCTTATTATGCATCCACATGTATGGTCCCTGTAGCGTGACCTTTACTAGCTCTGA
ATCAGAAGACAGAGCTATTTCAGAGGCTCTGTGTGCCCTCACTAGATAGTTTTTCTTCTGGGTTCAACCACTTTAGCCAGAATTTGATCA
AATTAAAAGTCTGTCATGGGGAAACTATATTTTTGAGCACATGGAACAAATTATACTTCCTCATTCATATTATGTTGATACAAAAGACCT
TGGCAGCCATTTCTCCCAGCAGTTTTAAAGGATGAACATTGGATTTCATGCCATCCCATAGAAAACCTGTTTTAAAATTTTAGGGATCTT
TACTTGGTCATACATGAAAAGTACACTGCTTAGAAATTATAGACTATTATGATCTGTCCACAGTGCCCATTGTCACTTCTTTGTCTCATT
TCTTCCCTTTGTTCCTTAGTCATCCAAATAAGCCTGAAAACCATAAGAGATATTACTTTATTGAATATGGTTGGCATTAAATTTAGCATT
TCATTATCTAACAAAATTAATATAAATTCCAGGACATGGTAAAATGTGTTTTAATAACCCCCAGACCCAAATGAAAATTTCAAAGTCAAT
ACCAGCAGATTCATGAAAGTAAATTTAGTCCTATAATTTTCAGCTTAATTATAAACAAAGGAACAAATAAGTGGAAGGGCAGCTATTACC
ATTCGCTTAGTCAAAACATTCGGTTACTGCCCTTTAATACACTCCTATCATCAGCACTTCCACCATGTATTACAAGTCTTGACCCATCCC
TGTCGTAACTCCAGTAAAAGTTACTGTTACTAGAAAATTTTTATCAATTAACTGACAAATAGTTTCTTTTTAAAGTAGTTTCTTCCATCT
TTATTCTGACTAGCTTCCAAAATGTGTTCCCTTTTTGAATCGAGGTTTTTTTGTTTTGTTTTGTTTTCTGAAAAAATCATACAACTTTGT
GCTTCTATTGCTTTTTTGTGTTTTGTTAAGCATGTCCCTTGGCCCAAATGGAAGAGGAAATGTTTAATTAATGCTTTTTAGTTTAAATAA
ATTGAATCATTTATAATAA

>22735_22735_1_DHX9-XPR1_DHX9_chr1_182829319_ENST00000367549_XPR1_chr1_180651495_ENST00000367589_length(amino acids)=1052AA_BP=444
MGDVKNFLYAWCGKRKMTPSYEIRAVGNKNRQKFMCEVQVEGYNYTGMGNSTNKKDAQSNAARDFVNYLVRINEIKSEEVPAFGVASPPP
LTDTPDTTANAEGDLPTTMGGPLPPHLALKAENNSEVGASGYGVPGPTWDRGANLKDYYSRKEEQEVQATLESEEVDLNAGLHGNWTLEN
AKARLNQYFQKEKIQGEYKYTQVGPDHNRSFIAEMTIYIKQLGRRIFAREHGSNKKLAAQSCALSLVRQLYHLGVVEAYSGLTKKKEGET
VEPYKVNLSQDLEHQLQNIIQELNLEILPPPEDPSVPVALNIGKLAQFEPSQRQNQVGVVPWSPPQSNWNPWTSSNIDEGPLAFATPEQI
SMDLKNELMYQLEQDHDLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQFILDDFIQNDRAAECNIVVTQAFKDML
YSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNELQSSLDAQKESTGVTTLRQRRKPVFHLSH
EERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVAHVEVAPFYTCKKINQLISETEAVVTNELEDG
DRQKAMKRLRVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVLAAVFKLETDRSIWPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNH
VLIFELNPRSNLSHQHLFEIAGFLGILWCLSLLACFFAPISVIPTYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKLLFRVFTAPFHKV
GFADFWLADQLNSLSVILMDLEYMICFYSLELKWDESKGLLPNNSEERGHSDTMVFFYLWIVFYIISSCYTLIWDLKMDWGLFDKNAGEN
TFLREEIVYPQKAYYYCAIIEDVILRFAWTIQISITSTTLLPHSGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPL
NADDQTLLEQMMDQDDGVRNRQKNRSWKYNQSISLRRPRLASQSKARDTKVLIEDTDDEANT

--------------------------------------------------------------
>22735_22735_2_DHX9-XPR1_DHX9_chr1_182829319_ENST00000367549_XPR1_chr1_180651495_ENST00000367590_length(transcript)=9649nt_BP=1442nt
GCGAGTTGCTGTGCGTTTCTCTGTTGTCTCGGTAGAAGGCCAGAGTCACACACGGTCCTAAGAGCTGGGCACCAGGAAGCGAAGGCTGAT
CTGAAGAAGACACTTGAATCATGGGTGACGTTAAAAATTTTCTGTATGCCTGGTGTGGCAAAAGGAAGATGACCCCATCCTATGAAATTA
GAGCAGTGGGGAACAAAAACAGGCAGAAATTCATGTGTGAGGTTCAGGTGGAAGGTTATAATTACACTGGCATGGGAAATTCCACCAATA
AAAAAGATGCACAAAGCAATGCTGCCAGAGACTTTGTTAACTATTTGGTTCGAATAAATGAAATAAAGAGTGAAGAAGTTCCAGCTTTTG
GGGTAGCATCTCCGCCCCCACTTACTGATACTCCTGACACTACAGCAAATGCTGAAGGAGATTTACCAACAACCATGGGAGGACCTCTTC
CTCCACATCTGGCTCTCAAAGCAGAAAATAATTCTGAGGTAGGGGCCTCTGGCTATGGTGTTCCTGGGCCCACCTGGGACCGAGGAGCCA
ACTTGAAGGATTACTACTCAAGAAAGGAAGAACAAGAAGTGCAAGCGACTCTAGAATCAGAAGAAGTGGATTTAAATGCTGGGCTTCATG
GAAACTGGACCTTGGAAAATGCTAAAGCTCGTCTAAACCAATATTTTCAGAAAGAAAAGATCCAAGGAGAATATAAGTACACCCAAGTGG
GTCCTGATCACAACAGGAGCTTTATTGCAGAAATGACCATTTATATCAAGCAGCTGGGCAGAAGGATTTTTGCACGAGAACATGGATCAA
ATAAGAAATTGGCAGCACAGTCCTGTGCCCTGTCACTTGTCAGACAACTGTACCATCTTGGAGTGGTTGAAGCTTACTCCGGACTTACAA
AGAAGAAGGAAGGAGAGACAGTGGAGCCTTACAAAGTAAACCTCTCTCAAGATTTAGAGCATCAGCTGCAAAACATCATTCAAGAGCTAA
ATCTTGAGATTTTGCCCCCGCCTGAAGATCCTTCTGTGCCAGTTGCACTCAACATTGGCAAATTGGCTCAGTTCGAACCATCTCAGCGAC
AAAACCAAGTGGGTGTGGTTCCTTGGTCACCTCCACAATCCAACTGGAATCCTTGGACTAGTAGCAACATTGATGAGGGGCCTCTGGCTT
TTGCTACTCCAGAGCAAATAAGCATGGACCTCAAGAATGAATTGATGTACCAGTTGGAACAGGATCATGATTTGCAAGCAATCTTGCAGG
AGAGAGAGTTACTGCCTGTGAAGAAATTTGAAAGTGAGATTCTGGAAGCAATCAGCCAAAATTCAGTTGTCATTATTAGAGGGGCTACTG
GATGTGGGAAAACCACACAGGTTCCCCAGTTCATTCTAGATGACTTTATCCAGAATGACCGAGCAGCAGAGTGTAACATCGTAGTAACTC
AGGCTTTCAAGGATATGCTGTATTCAGCTCAGGACCAGGCACCTTCTGTGGAAGTTACAGATGAGGACACAGTAAAGAGGTATTTTGCCA
AGTTTGAAGAGAAGTTTTTCCAAACCTGTGAAAAAGAACTTGCCAAAATCAACACATTTTATTCAGAGAAGCTCGCAGAGGCTCAGCGCA
GGTTTGCTACACTTCAGAATGAGCTTCAGTCATCACTGGATGCACAGAAAGAAAGCACTGGTGTTACTACGCTGCGACAACGCAGAAAGC
CAGTCTTCCACTTGTCCCATGAGGAACGTGTCCAACATAGAAATATTAAAGACCTTAAACTGGCCTTCAGTGAGTTCTACCTCAGTCTAA
TCCTGCTGCAGAACTATCAGAATCTGAATTTTACAGGGTTTCGAAAAATCCTGAAAAAGCATGACAAGATCCTGGAAACATCTCGTGGAG
CAGATTGGCGAGTGGCTCACGTAGAGGTGGCCCCATTTTATACATGCAAGAAAATCAACCAGCTTATCTCTGAAACTGAGGCTGTAGTGA
CCAATGAACTTGAAGATGGTGACAGACAAAAGGCTATGAAGCGTTTACGTGTCCCCCCTTTGGGAGCTGCTCAGCCTGCACCAGCATGGA
CTACTTTTAGAGTTGGCCTATTTTGTGGAATATTCATTGTACTGAATATTACCCTTGTGCTTGCCGCTGTATTTAAACTTGAAACAGATA
GAAGTATATGGCCCTTGATAAGAATCTATCGGGGTGGCTTTCTTCTGATTGAATTCCTTTTTCTACTGGGCATCAACACGTATGGTTGGA
GACAGGCTGGAGTAAACCATGTACTCATCTTTGAACTTAATCCGAGAAGCAATTTGTCTCATCAACATCTCTTTGAGATTGCTGGATTCC
TCGGGATATTGTGGTGCCTGAGCCTTCTGGCATGCTTCTTTGCTCCAATTAGTGTCATCCCCACATATGTGTATCCACTTGCCCTTTATG
GATTTATGGTTTTCTTCCTTATCAACCCCACCAAAACTTTCTACTATAAATCCCGGTTTTGGCTGCTTAAACTGCTGTTTCGAGTATTTA
CAGCCCCCTTCCATAAGGTAGGCTTTGCTGATTTCTGGCTGGCGGATCAGCTGAACAGCCTGTCAGTGATACTGATGGACCTGGAATATA
TGATCTGCTTCTACAGTTTGGAGCTCAAATGGGATGAAAGTAAGGGCCTGTTGCCAAATAATTCAGAAGAATCAGGAATTTGCCACAAAT
ATACATATGGTGTGCGGGCCATTGTTCAGTGCATTCCTGCTTGGCTTCGCTTCATCCAGTGCCTGCGCCGATATCGAGACACAAAAAGGG
CCTTTCCTCATTTAGTTAATGCTGGCAAATACTCCACAACTTTCTTCATGGTGACGTTTGCAGCCCTTTACAGCACTCACAAAGAACGAG
GTCACTCGGACACTATGGTGTTCTTTTACCTGTGGATTGTCTTTTATATCATCAGTTCCTGCTATACCCTCATCTGGGATCTCAAGATGG
ACTGGGGTCTCTTCGATAAGAATGCTGGAGAGAACACTTTCCTCCGGGAAGAGATTGTATACCCCCAAAAAGCCTACTACTACTGTGCCA
TAATAGAGGATGTGATTCTGCGCTTTGCTTGGACTATCCAAATCTCGATTACCTCTACAACTTTGTTGCCTCATTCTGGGGACATCATTG
CTACTGTCTTTGCCCCACTTGAGGTTTTCCGGCGATTTGTGTGGAACTTCTTCCGCCTGGAGAATGAACATCTGAATAACTGTGGTGAAT
TCCGTGCTGTGCGGGACATCTCTGTGGCCCCCCTGAACGCAGATGATCAGACTCTCCTAGAACAGATGATGGACCAGGATGATGGGGTAC
GAAACCGCCAGAAGAATCGGTCATGGAAGTACAACCAGAGCATATCCCTGCGCCGGCCTCGCCTCGCTTCTCAATCCAAGGCTCGTGACA
CTAAGGTATTGATAGAAGACACAGATGATGAAGCTAACACTTGAATTTTCTGAAGTCTAGCTTAACATCTTTGGTTTTCCTACTCTACAA
TCCTTTCCTCGACCAACGCAACCTCTAGTACCTTTCCAGCCGAAAACAGGAGAAAACACATAACACATTTTCCGAGCTCTTCCGGATCGG
ATCCTATGGACTCCAAACAAGCTCACTGTGTTTCTTTTCTTTTCTTCTGGTTTAATTTTAATTTTCTATTTTCAAAACAAATATTTACTT
CATTTGCCAATCAGAGGATGTTTTAAGAAACAAAACATAGTATCTTATGGATTGTTTACAATCACAAGGACATAGATACCTATCAGGATG
AAGAACAGGCATTGCAAGGACCCTCTGATGGGACGGTACTGAGATATCTCGGCTTCCGCTCAGCCCGGTTTTGACTGGTTGAAACCGGAC
ATTGGTTTTTAAATTTTTTGTCAGTTTATGTGGAGAATTTTTTTCTTTCCTTCATACCCAGCGCAAAGGCACTGGCCGCACTTGCAGGAA
AAGTGCAACTTAAAGCAGTACCTTCATTCATGAAGCTACTTTTTAATTTGATGTAACTTTTCTTATTTTGGGAAGGGTTGCTGGGTGGGT
GGGAAATATGATGTATTTGTTACACATAGTTTTCTCATTATTTATGAAACTTAACCATACAGAATGATATAACTCCTGTGCAATGAAGGT
GATAACAGTAAAAGAAGGCAGGGGAAACTTACGTTGGATGACATTTATGAGGGTCAGTCCCACATACCTCTTTCAGGAGACAACTTGCAC
CAGTTTGACCTTTTCTTTTCTTTGTTTTTATTTTAAGCCAAAGTTTCATTGCTAACTTCTTAAGTTGCTGCTGCTTTAGAGTCCTGAGCA
TATCTCTCATAACAAGGAATCCCACACTTCACACCACCGGCTGAATTTCATGGAAGAGGTTCTGATAATTTTTTTAACTTTTTAAGGAAC
AGATGTGGAATACACTGGCCCATATTTCAACCTTAACAGCTGAAGCTATGCCTTATTATGCATCCACATGTATGGTCCCTGTAGCGTGAC
CTTTACTAGCTCTGAATCAGAAGACAGAGCTATTTCAGAGGCTCTGTGTGCCCTCACTAGATAGTTTTTCTTCTGGGTTCAACCACTTTA
GCCAGAATTTGATCAAATTAAAAGTCTGTCATGGGGAAACTATATTTTTGAGCACATGGAACAAATTATACTTCCTCATTCATATTATGT
TGATACAAAAGACCTTGGCAGCCATTTCTCCCAGCAGTTTTAAAGGATGAACATTGGATTTCATGCCATCCCATAGAAAACCTGTTTTAA
AATTTTAGGGATCTTTACTTGGTCATACATGAAAAGTACACTGCTTAGAAATTATAGACTATTATGATCTGTCCACAGTGCCCATTGTCA
CTTCTTTGTCTCATTTCTTCCCTTTGTTCCTTAGTCATCCAAATAAGCCTGAAAACCATAAGAGATATTACTTTATTGAATATGGTTGGC
ATTAAATTTAGCATTTCATTATCTAACAAAATTAATATAAATTCCAGGACATGGTAAAATGTGTTTTAATAACCCCCAGACCCAAATGAA
AATTTCAAAGTCAATACCAGCAGATTCATGAAAGTAAATTTAGTCCTATAATTTTCAGCTTAATTATAAACAAAGGAACAAATAAGTGGA
AGGGCAGCTATTACCATTCGCTTAGTCAAAACATTCGGTTACTGCCCTTTAATACACTCCTATCATCAGCACTTCCACCATGTATTACAA
GTCTTGACCCATCCCTGTCGTAACTCCAGTAAAAGTTACTGTTACTAGAAAATTTTTATCAATTAACTGACAAATAGTTTCTTTTTAAAG
TAGTTTCTTCCATCTTTATTCTGACTAGCTTCCAAAATGTGTTCCCTTTTTGAATCGAGGTTTTTTTGTTTTGTTTTGTTTTCTGAAAAA
ATCATACAACTTTGTGCTTCTATTGCTTTTTTGTGTTTTGTTAAGCATGTCCCTTGGCCCAAATGGAAGAGGAAATGTTTAATTAATGCT
TTTTAGTTTAAATAAATTGAATCATTTATAATAATCAGTGTTAACAATTTAGTGACCCTTGGTAGGTTAAAGGTTGCATTATTTATACTT
GAGATTTTTTTCCCCTAACTATTCTGTTTTTTGTACTTTAAAACTATGGGGGAAATATCACTGGTCTGTCAAGAAACAGCAGTAATTATT
ACTGAGTTAAATTGAAAAGTCCAGTGGACCAGGCATTTCTTATATAAATAAAATTGGTGGTACTAATGTGTATCCAGAGACATTTGAATT
ATTAACTTTATTCTTTATTAGTGAATCTCTATGATGGCACACATAAAATCTTACAGTTGACTTCTGCTGTTTGAATTCCCCAGTGTTTTT
ACATTAATGTATCCTATGGCCAGTTTAGTCTTTCTTCAACTGTTACAGTTCTAGGCCCTAATCGGTCTTATTCTTTCACATATGATGCAA
TGATAGATGTAATCCTTTTCTGAAGTGTTTGTCGGATTGGCATAGTCTATTCAAAAATAAGGCTTATGTAACTTTCAGCTTGCTATGTGA
CAGAAGTTTAAATGTGTATTTAAGTACACAGCTTTATGTTCCTCTTAAAGCTGTAAAGAGAAAAGAGGACTTTTCCTCATCAAGAGAGCT
TGGGAGACAAAGCATACATTTAATTTTTTTCTTTCAAAAAAGGCAATGTGCACTTTCCTCTCCTAAATTTTATATGCCCTAGCAGTTGCG
AATGTTGTGTCCACCTTACAATTTGATTGGAGGCTCCCATACACTGAAACTCTCAATAGAATTCTTAAAAATGAACATCAGCTGGGCGCA
GTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACGAGCTCAGGAGTTCGAGACCAGCCTGACCAACATGGT
GAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGACTGAGGCAGGAG
AATTGCTTAAACCTGGGAAGCAGAGGTTGCAGTGAGACTAGATCATGCCACTGCACTCCACTGCCACTGCCTGGGCAACAGAGCAAGACT
CCATCTCAAAAACAAACAAAAAAAATCACAGACTCATTTTAAAGGAGCAGCAACCTAACCAAATACAAACTTCATTTGATTTTAGGTTTA
GAAATTCTAGTTTTATTTTGGAGAATCACTCAGTTTTTAATATCAATTAAAATAGTCCTCAAAGGAATGAAGAGGAAGTCTAAATAAATG
AATAAAACTCATTTTTCATTTTATGGTAGTATAGAAAGCATTGATGTGTGTAGAGAAATTAAAAGACAAGAGTGGTTTACTGTCTATGCA
CAAATGAGTGCCTATATTTAAGGCTGCCTATACCATTACAGTGGCGTAATTGGTGATTTCATAGCATACAGAGAAACAATGAAATCAAAG
ATTAAATCATTAGGTTATGATGGTCATTTGTAAGATTGGAAAGTAGTCAAAAACCCATGTGCAACTTTTTTTCAGCACTCTACCATTAGG
CTCCTTAGGCAAGCTGCTTAACTTCCGTCAGAAGCAAAGGTGTGGGAGAACACCATTCACCTCAGTAGTAACTTATAAAAACCGTTTAAA
GAAGGAAAATGGGCCCCAGCCCCTAGGATCCCTGACTTCCTGATATTCTAAACATGAGAGTTCTGTGACTTTAACTGAGCTCTTTACCAG
AAGTAACGTGTTGATGTATATTATCTTTCCACCATGCTTTGACCAAAGTACATTCACAGTAACTAGAGAAAGCAGATCATCCATTTCTGG
ATAGGTGAACTACGGCAAGGTAAGAACAGAAAAAAGTAAAGTAGTATTGAGTCATGCAGGTATCAGATTAACAGACATTCATTGAAGATA
AGTGAAATAACTTTGGAGATAGCAGAGAAGAGCAAGAAGATGTTGGACGTTGGCAGTAAGCCGCAGCAAGGCAGTTAGGAAAGTACGTGA
GCCTGATGACGCGAAGGTGATGCCTCCATCTGTCCGCTTAGTGGTTATTAAATTGCTGGGAAAGACCTGCCTTTATTTTCCTATCATCTT
TTCCCCATTACTTTGCATTATTCAGGAAATAATTATTTATTCCCAAATGCAGTTTTCTAAGCAGTGACCACAAAAATTTCTTATTCTAAG
GAAAATAATTAAGAAAATAACCCTATCTGTGGCATTGTTTTAAAATGTGGGATACAAATCTGGTAAGCAGATTTCAGGTCATTATTGTTT
TCTTTTAATGGTTTACATGAAATTTTCCTCTCAAAAAACAAGTACCTCTTACTGTATAACATTTGAGTTTTTAAAATTGAGATAGCTTCT
GAGAGAAAAAAAGAAAGTTGAATTTGTAGCTCTCTCAACTACAAAATCACCACACTTTTCTCAAATCTAATAGGAATTCAGTGTCATTAC
AGATACGGTCTCTAGTGACCAGGTGAAGACAATTGAAGCTTTGGTAGAACTTCTGCAAAAGTTAGGTAAAGAAGAATAAATCCAATTTAT
CAGCTTTGTTCATATTCTTTTTCTGAGTGATCTAAATTTTTCTTGCTTGTGATCATTAGCTAAGACAAGGAGTGTTAAAGGTTTTCTAAA
TGCAAACACATACGTTTCTGCATTTCAGAAGTCAGTCTTGATAGTAAATCCTACAAACTCTCAACTTTCTGCATTGTATTTTAAGTCTAT
ACAATGTTAGAGCACATGGTAATGTGGGACAGAGTTGATTATATGATAGCATGAGAAATTTGCACTGGTTGGTGTTACAAACCAATGATC
TAACCAGCATACTCTCCAAATATGAAAAAGTAAAAACATCTCATTAGGTTTGGAAGAGCCTAAGGTAGTCCATACAGGAAGTTTGCCTGA
GAACAGAGAGGAGCCTGTTGATTGGCATGGCTCATGATGCCTTTCTTGTATGAATTATCAAAACTGATACTGAGTTGCCCCTAGAAAACA
GCCTTCCAGAATATGTTTGCTTATTTATGGTGGAAGAGGAAGTGAGAACAAGATGAGAGTTTCCCTTAAAGTGAGGAGAATCATTATACA
ACTTTGCAACTGAAGTATGTTTCCTTGTAGCAAACCTTTGGTTTATTTTATCGTCAAATCAAAGCCACCCTCAGTTTTTTGTATGGTGCC
ATCAACCTAAGGAGGACAATCAAATAACCTATTGTTTGCCTTGGATTCAGTATATCTACTAAGTACACAGTCTCGTATACCTTCAAACCA
GTTACTTGACTAAACTTCCACCATATTACCTTAGTTCTTCCTATGCCCTTTCCTCTGTGCCACCACAAATCAGAGGGAAAGACTGCAGTA
CTTCTAGAAAGTTGTGGACTTCTAAGAAAGAGCCAGGCTTCCATCTCACTATCCCTTGATCATTATCTCTGAAGTCCCTACCTGCACTTC
CCTGATTGCCCTGTAGCAACACCAGCATGGTGGGAATTGGAGGGAAAGATTGTGGAAAATCCCTAAAGGGTCATTGTTCATGACGTTATT
TTGAATTGTAAAATTGTGAGCCACTCACATTTCAATTACAAAAAGAACAGAACTCTTAATCACGTTGTGAAGATTAATTTCTTGCCATTT
TCTGGATTAGCACAGAAGCTTGTATCAATGAAGAGTATTTAGGAGGGGAATAGGGGGAAAATTGTATTTTTCTGTTCAAACTCTCTCCTT
CTATTTGTGTTTCCTTCACCCCTCTCCCTCCACCACACTGTGTTGGTCAAATGATACTATTCTATGAAACCCTGAGCTATAGTTGTCAAA
AGTAACTATGGATTGTGATTAGTCCTCTGTGGGTGCTTCCTTCCCTCTTTTTTCTCCCTCACTCTCTTTCTCAGTCTCCACTCTGGTAAA
TGGAAAAGGTGATGTCGAAGAATTGATGCTTGCTTGGACTCATGTTGTATCTGTGACTATGCTATTAGCTGTCTCCTTTTTCCTTCCTAT
ATGGGTAGAATTCTTATGACTTATGAAGTTCCCTTCTTGATAAGTAGGTTAAATGCACAATGTGGTACTGTTTTATAGTTTCTAGATGGT
TGTATAAAGCAAAAAGTTAATGTGGTTATGTGTTTTTAAAGAAAATAAGTGATTGGTCACTAAACTCTGTCCTTTTTTCATTATTACAAT
TTCTCTCTGTTTTCCAACA

>22735_22735_2_DHX9-XPR1_DHX9_chr1_182829319_ENST00000367549_XPR1_chr1_180651495_ENST00000367590_length(amino acids)=1117AA_BP=444
MGDVKNFLYAWCGKRKMTPSYEIRAVGNKNRQKFMCEVQVEGYNYTGMGNSTNKKDAQSNAARDFVNYLVRINEIKSEEVPAFGVASPPP
LTDTPDTTANAEGDLPTTMGGPLPPHLALKAENNSEVGASGYGVPGPTWDRGANLKDYYSRKEEQEVQATLESEEVDLNAGLHGNWTLEN
AKARLNQYFQKEKIQGEYKYTQVGPDHNRSFIAEMTIYIKQLGRRIFAREHGSNKKLAAQSCALSLVRQLYHLGVVEAYSGLTKKKEGET
VEPYKVNLSQDLEHQLQNIIQELNLEILPPPEDPSVPVALNIGKLAQFEPSQRQNQVGVVPWSPPQSNWNPWTSSNIDEGPLAFATPEQI
SMDLKNELMYQLEQDHDLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQFILDDFIQNDRAAECNIVVTQAFKDML
YSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNELQSSLDAQKESTGVTTLRQRRKPVFHLSH
EERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVAHVEVAPFYTCKKINQLISETEAVVTNELEDG
DRQKAMKRLRVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVLAAVFKLETDRSIWPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNH
VLIFELNPRSNLSHQHLFEIAGFLGILWCLSLLACFFAPISVIPTYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKLLFRVFTAPFHKV
GFADFWLADQLNSLSVILMDLEYMICFYSLELKWDESKGLLPNNSEESGICHKYTYGVRAIVQCIPAWLRFIQCLRRYRDTKRAFPHLVN
AGKYSTTFFMVTFAALYSTHKERGHSDTMVFFYLWIVFYIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYYCAIIEDVIL
RFAWTIQISITSTTLLPHSGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQTLLEQMMDQDDGVRNRQKNR
SWKYNQSISLRRPRLASQSKARDTKVLIEDTDDEANT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DHX9-XPR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+1228230_325444.01271.0BRCA1
HgeneDHX9chr1:182829319chr1:180651495ENST00000367549+12281_250444.01271.0CREBBP


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DHX9-XPR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DHX9-XPR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4225335BASAL GANGLIA CALCIFICATION, IDIOPATHIC, 62CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0004782Basal Ganglia Diseases1CTD_human
TgeneC0006663Calcinosis1CTD_human
TgeneC0015371Extrapyramidal Disorders1CTD_human
TgeneC0015624Fanconi Syndrome1GENOMICS_ENGLAND
TgeneC0263628Tumoral calcinosis1CTD_human
TgeneC0393590Fahr's syndrome (disorder)1ORPHANET
TgeneC0521174Microcalcification1CTD_human
TgeneC0750951Lenticulostriate Disorders1CTD_human