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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DMD-FN1 (FusionGDB2 ID:HG1756TG2335)

Fusion Gene Summary for DMD-FN1

Fusion gene summary

Fusion gene information	Fusion gene name: DMD-FN1
	Fusion gene ID: hg1756tg2335
		Hgene	Tgene
	Gene symbol	DMD	FN1
	Gene ID	1756	2335
	Gene name	dystrophin	fibronectin 1
	Synonyms	BMD\|CMD3B\|DXS142\|DXS164\|DXS206\|DXS230\|DXS239\|DXS268\|DXS269\|DXS270\|DXS272\|MRX85	CIG\|ED-B\|FINC\|FN\|FNZ\|GFND\|GFND2\|LETS\|MSF\|SMDCF
	Cytomap	('DMD')('FN1') Xp21.2-p21.1	2q35
	Type of gene	protein-coding	protein-coding
	Description	dystrophin	fibronectincold-insoluble globulinepididymis secretory sperm binding proteinmigration-stimulating factor
	Modification date	20200329	20200329
	UniProtAcc	P11532	P02751
	Ensembl transtripts involved in fusion gene	ENST00000445312, ENST00000288447, ENST00000343523, ENST00000357033, ENST00000359836, ENST00000361471, ENST00000378677, ENST00000378680, ENST00000378702, ENST00000378707, ENST00000378723, ENST00000474231, ENST00000541735,
Fusion gene scores	* DoF score	32 X 35 X 5=5600	35 X 39 X 9=12285
	# samples	36	42
	** MAII score	log2(36/5600*10)=-3.95935801550265 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(42/12285*10)=-4.8703647195834 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DMD [Title/Abstract] AND FN1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DMD(31526329)-FN1(216230250), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DMD	GO:0043043	peptide biosynthetic process	16000376
Tgene	FN1	GO:0001932	regulation of protein phosphorylation	11792823
Tgene	FN1	GO:0008284	positive regulation of cell proliferation	25834989
Tgene	FN1	GO:0010628	positive regulation of gene expression	25834989
Tgene	FN1	GO:0018149	peptide cross-linking	3997886
Tgene	FN1	GO:0034446	substrate adhesion-dependent cell spreading	16236823
Tgene	FN1	GO:0035987	endodermal cell differentiation	23154389
Tgene	FN1	GO:0048146	positive regulation of fibroblast proliferation	25834989
Tgene	FN1	GO:0051702	interaction with symbiont	12167537\|12421310\|19429745
Tgene	FN1	GO:0070372	regulation of ERK1 and ERK2 cascade	11792823
Tgene	FN1	GO:1901166	neural crest cell migration involved in autonomic nervous system development	26571399
Tgene	FN1	GO:1904237	positive regulation of substrate-dependent cell migration, cell attachment to substrate	25834989
Tgene	FN1	GO:2001202	negative regulation of transforming growth factor-beta secretion	25834989

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-KD-A5QU-01A	DMD	chrX	31526329	-	FN1	chr2	216230250	-

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Fusion Gene ORF analysis for DMD-FN1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000445312	ENST00000323926	DMD	chrX	31526329	-	FN1	chr2	216230250	-
5UTR-3CDS	ENST00000445312	ENST00000336916	DMD	chrX	31526329	-	FN1	chr2	216230250	-
5UTR-3CDS	ENST00000445312	ENST00000354785	DMD	chrX	31526329	-	FN1	chr2	216230250	-
5UTR-3CDS	ENST00000445312	ENST00000357867	DMD	chrX	31526329	-	FN1	chr2	216230250	-
5UTR-3CDS	ENST00000445312	ENST00000421182	DMD	chrX	31526329	-	FN1	chr2	216230250	-
5UTR-3UTR	ENST00000445312	ENST00000345488	DMD	chrX	31526329	-	FN1	chr2	216230250	-
5UTR-3UTR	ENST00000445312	ENST00000346544	DMD	chrX	31526329	-	FN1	chr2	216230250	-
5UTR-3UTR	ENST00000445312	ENST00000356005	DMD	chrX	31526329	-	FN1	chr2	216230250	-
5UTR-3UTR	ENST00000445312	ENST00000357009	DMD	chrX	31526329	-	FN1	chr2	216230250	-
5UTR-3UTR	ENST00000445312	ENST00000359671	DMD	chrX	31526329	-	FN1	chr2	216230250	-
5UTR-3UTR	ENST00000445312	ENST00000432072	DMD	chrX	31526329	-	FN1	chr2	216230250	-
5UTR-3UTR	ENST00000445312	ENST00000443816	DMD	chrX	31526329	-	FN1	chr2	216230250	-
5UTR-3UTR	ENST00000445312	ENST00000446046	DMD	chrX	31526329	-	FN1	chr2	216230250	-
5UTR-intron	ENST00000445312	ENST00000426059	DMD	chrX	31526329	-	FN1	chr2	216230250	-
5UTR-intron	ENST00000445312	ENST00000490833	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000288447	ENST00000323926	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000288447	ENST00000336916	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000288447	ENST00000354785	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000288447	ENST00000357867	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000288447	ENST00000421182	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000343523	ENST00000323926	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000343523	ENST00000336916	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000343523	ENST00000354785	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000343523	ENST00000357867	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000343523	ENST00000421182	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000357033	ENST00000323926	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000357033	ENST00000336916	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000357033	ENST00000354785	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000357033	ENST00000357867	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000357033	ENST00000421182	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000359836	ENST00000323926	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000359836	ENST00000336916	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000359836	ENST00000354785	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000359836	ENST00000357867	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000359836	ENST00000421182	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000361471	ENST00000323926	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000361471	ENST00000336916	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000361471	ENST00000354785	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000361471	ENST00000357867	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000361471	ENST00000421182	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378677	ENST00000323926	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378677	ENST00000336916	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378677	ENST00000354785	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378677	ENST00000357867	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378677	ENST00000421182	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378680	ENST00000323926	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378680	ENST00000336916	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378680	ENST00000354785	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378680	ENST00000357867	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378680	ENST00000421182	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378702	ENST00000323926	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378702	ENST00000336916	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378702	ENST00000354785	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378702	ENST00000357867	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378702	ENST00000421182	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378707	ENST00000323926	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378707	ENST00000336916	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378707	ENST00000354785	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378707	ENST00000357867	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378707	ENST00000421182	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378723	ENST00000323926	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378723	ENST00000336916	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378723	ENST00000354785	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378723	ENST00000357867	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000378723	ENST00000421182	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000474231	ENST00000323926	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000474231	ENST00000336916	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000474231	ENST00000354785	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000474231	ENST00000357867	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000474231	ENST00000421182	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000541735	ENST00000323926	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000541735	ENST00000336916	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000541735	ENST00000354785	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000541735	ENST00000357867	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3CDS	ENST00000541735	ENST00000421182	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000288447	ENST00000345488	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000288447	ENST00000346544	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000288447	ENST00000356005	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000288447	ENST00000357009	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000288447	ENST00000359671	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000288447	ENST00000432072	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000288447	ENST00000443816	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000288447	ENST00000446046	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000343523	ENST00000345488	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000343523	ENST00000346544	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000343523	ENST00000356005	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000343523	ENST00000357009	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000343523	ENST00000359671	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000343523	ENST00000432072	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000343523	ENST00000443816	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000343523	ENST00000446046	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000357033	ENST00000345488	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000357033	ENST00000346544	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000357033	ENST00000356005	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000357033	ENST00000357009	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000357033	ENST00000359671	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000357033	ENST00000432072	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000357033	ENST00000443816	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000357033	ENST00000446046	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000359836	ENST00000345488	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000359836	ENST00000346544	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000359836	ENST00000356005	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000359836	ENST00000357009	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000359836	ENST00000359671	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000359836	ENST00000432072	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000359836	ENST00000443816	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000359836	ENST00000446046	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000361471	ENST00000345488	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000361471	ENST00000346544	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000361471	ENST00000356005	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000361471	ENST00000357009	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000361471	ENST00000359671	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000361471	ENST00000432072	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000361471	ENST00000443816	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000361471	ENST00000446046	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378677	ENST00000345488	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378677	ENST00000346544	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378677	ENST00000356005	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378677	ENST00000357009	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378677	ENST00000359671	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378677	ENST00000432072	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378677	ENST00000443816	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378677	ENST00000446046	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378680	ENST00000345488	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378680	ENST00000346544	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378680	ENST00000356005	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378680	ENST00000357009	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378680	ENST00000359671	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378680	ENST00000432072	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378680	ENST00000443816	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378680	ENST00000446046	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378702	ENST00000345488	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378702	ENST00000346544	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378702	ENST00000356005	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378702	ENST00000357009	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378702	ENST00000359671	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378702	ENST00000432072	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378702	ENST00000443816	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378702	ENST00000446046	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378707	ENST00000345488	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378707	ENST00000346544	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378707	ENST00000356005	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378707	ENST00000357009	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378707	ENST00000359671	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378707	ENST00000432072	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378707	ENST00000443816	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378707	ENST00000446046	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378723	ENST00000345488	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378723	ENST00000346544	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378723	ENST00000356005	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378723	ENST00000357009	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378723	ENST00000359671	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378723	ENST00000432072	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378723	ENST00000443816	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000378723	ENST00000446046	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000474231	ENST00000345488	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000474231	ENST00000346544	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000474231	ENST00000356005	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000474231	ENST00000357009	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000474231	ENST00000359671	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000474231	ENST00000432072	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000474231	ENST00000443816	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000474231	ENST00000446046	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000541735	ENST00000345488	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000541735	ENST00000346544	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000541735	ENST00000356005	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000541735	ENST00000357009	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000541735	ENST00000359671	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000541735	ENST00000432072	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000541735	ENST00000443816	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-3UTR	ENST00000541735	ENST00000446046	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000288447	ENST00000426059	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000288447	ENST00000490833	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000343523	ENST00000426059	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000343523	ENST00000490833	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000357033	ENST00000426059	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000357033	ENST00000490833	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000359836	ENST00000426059	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000359836	ENST00000490833	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000361471	ENST00000426059	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000361471	ENST00000490833	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000378677	ENST00000426059	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000378677	ENST00000490833	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000378680	ENST00000426059	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000378680	ENST00000490833	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000378702	ENST00000426059	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000378702	ENST00000490833	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000378707	ENST00000426059	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000378707	ENST00000490833	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000378723	ENST00000426059	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000378723	ENST00000490833	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000474231	ENST00000426059	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000474231	ENST00000490833	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000541735	ENST00000426059	DMD	chrX	31526329	-	FN1	chr2	216230250	-
intron-intron	ENST00000541735	ENST00000490833	DMD	chrX	31526329	-	FN1	chr2	216230250	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for DMD-FN1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

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Fusion Protein Features for DMD-FN1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:31526329/:216230250)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DMD P11532	FN1 P02751
FUNCTION: Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250\|UniProtKB:P11531, ECO:0000269\|PubMed:16710609}.	FUNCTION: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation (PubMed:34089617). {ECO:0000250\|UniProtKB:P11276, ECO:0000269\|PubMed:3024962, ECO:0000269\|PubMed:34089617, ECO:0000269\|PubMed:3593230, ECO:0000269\|PubMed:3900070, ECO:0000269\|PubMed:7989369}.; FUNCTION: [Anastellin]: Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. {ECO:0000269\|PubMed:11209058, ECO:0000269\|PubMed:15665290, ECO:0000269\|PubMed:19379667, ECO:0000269\|PubMed:8114919}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for DMD-FN1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DMD-FN1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for DMD-FN1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	DMD	P11532	DB15593	Golodirsen	Inducer	Biotech	Approved
Tgene	FN1	P02751	DB08888	Ocriplasmin	Cleavage	Biotech	Approved
Tgene	FN1	P02751	DB08888	Ocriplasmin	Cleavage	Biotech	Approved
Tgene	FN1	P02751	DB14548	Zinc sulfate, unspecified form	Ligand\|Modulator	Small molecule	Approved\|Experimental
Tgene	FN1	P02751	DB14548	Zinc sulfate, unspecified form	Ligand\|Modulator	Small molecule	Approved\|Experimental
Tgene	FN1	P02751	DB01593	Zinc		Small molecule	Approved\|Investigational
Tgene	FN1	P02751	DB01593	Zinc		Small molecule	Approved\|Investigational
Tgene	FN1	P02751	DB14487	Zinc acetate		Small molecule	Approved\|Investigational
Tgene	FN1	P02751	DB14487	Zinc acetate		Small molecule	Approved\|Investigational
Tgene	FN1	P02751	DB14533	Zinc chloride	Ligand\|Modulator	Small molecule	Approved\|Investigational
Tgene	FN1	P02751	DB14533	Zinc chloride	Ligand\|Modulator	Small molecule	Approved\|Investigational

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Related Diseases for DMD-FN1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	DMD	C0013264	Muscular Dystrophy, Duchenne	18	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	DMD	C0917713	Becker Muscular Dystrophy	13	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	DMD	C3542021	Duchenne and Becker Muscular Dystrophy	11	CTD_human
Hgene	DMD	C0026850	Muscular Dystrophy	4	CTD_human
Hgene	DMD	C3668940	Dmd-Associated Dilated Cardiomyopathy	4	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	DMD	C0033141	Cardiomyopathies, Primary	3	CTD_human
Hgene	DMD	C0036529	Myocardial Diseases, Secondary	3	CTD_human
Hgene	DMD	C0878544	Cardiomyopathies	3	CTD_human;GENOMICS_ENGLAND
Hgene	DMD	C0006663	Calcinosis	1	CTD_human
Hgene	DMD	C0007193	Cardiomyopathy, Dilated	1	CTD_human
Hgene	DMD	C0018800	Cardiomegaly	1	CTD_human
Hgene	DMD	C0023269	leiomyosarcoma	1	CTD_human
Hgene	DMD	C0026851	Muscular Dystrophy, Animal	1	CTD_human
Hgene	DMD	C0027540	Necrosis	1	CTD_human
Hgene	DMD	C0027626	Neoplasm Invasiveness	1	CTD_human
Hgene	DMD	C0027627	Neoplasm Metastasis	1	CTD_human
Hgene	DMD	C0032460	Polycystic Ovary Syndrome	1	CTD_human
Hgene	DMD	C0038220	Status Epilepticus	1	CTD_human
Hgene	DMD	C0151786	Muscle Weakness	1	CTD_human
Hgene	DMD	C0205815	Leiomyosarcoma, Epithelioid	1	CTD_human
Hgene	DMD	C0205816	Leiomyosarcoma, Myxoid	1	CTD_human
Hgene	DMD	C0206656	Embryonal Rhabdomyosarcoma	1	CTD_human
Hgene	DMD	C0238198	Gastrointestinal Stromal Tumors	1	CTD_human
Hgene	DMD	C0242973	Ventricular Dysfunction	1	CTD_human
Hgene	DMD	C0263628	Tumoral calcinosis	1	CTD_human
Hgene	DMD	C0270823	Petit mal status	1	CTD_human
Hgene	DMD	C0311335	Grand Mal Status Epilepticus	1	CTD_human
Hgene	DMD	C0340427	Familial dilated cardiomyopathy	1	ORPHANET
Hgene	DMD	C0393734	Complex Partial Status Epilepticus	1	CTD_human
Hgene	DMD	C0521174	Microcalcification	1	CTD_human
Hgene	DMD	C0751522	Status Epilepticus, Subclinical	1	CTD_human
Hgene	DMD	C0751523	Non-Convulsive Status Epilepticus	1	CTD_human
Hgene	DMD	C0751524	Simple Partial Status Epilepticus	1	CTD_human
Hgene	DMD	C1136382	Sclerocystic Ovaries	1	CTD_human
Hgene	DMD	C1383860	Cardiac Hypertrophy	1	CTD_human
Hgene	DMD	C1449563	Cardiomyopathy, Familial Idiopathic	1	CTD_human
Hgene	DMD	C2931498	Mental Retardation, X-Linked 1	1	ORPHANET
Hgene	DMD	C3179349	Gastrointestinal Stromal Sarcoma	1	CTD_human
Tgene		C0020538	Hypertensive disease	2	CTD_human
Tgene		C0432221	Spondylometaphyseal dysplasia, 'corner fracture' type	2	GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0000786	Spontaneous abortion	1	CTD_human
Tgene		C0000822	Abortion, Tubal	1	CTD_human
Tgene		C0003504	Aortic Valve Insufficiency	1	CTD_human
Tgene		C0006142	Malignant neoplasm of breast	1	CTD_human;UNIPROT
Tgene		C0007097	Carcinoma	1	CTD_human
Tgene		C0007621	Neoplastic Cell Transformation	1	CTD_human
Tgene		C0010346	Crohn Disease	1	CTD_human
Tgene		C0011849	Diabetes Mellitus	1	CTD_human
Tgene		C0011881	Diabetic Nephropathy	1	CTD_human
Tgene		C0017636	Glioblastoma	1	CTD_human
Tgene		C0017667	Nodular glomerulosclerosis	1	CTD_human
Tgene		C0017668	Focal glomerulosclerosis	1	CTD_human
Tgene		C0024667	Animal Mammary Neoplasms	1	CTD_human
Tgene		C0024668	Mammary Neoplasms, Experimental	1	CTD_human
Tgene		C0027626	Neoplasm Invasiveness	1	CTD_human
Tgene		C0034069	Pulmonary Fibrosis	1	CTD_human
Tgene		C0041956	Ureteral obstruction	1	CTD_human
Tgene		C0085762	Alcohol abuse	1	PSYGENET
Tgene		C0086432	Hyalinosis, Segmental Glomerular	1	CTD_human
Tgene		C0149721	Left Ventricular Hypertrophy	1	CTD_human
Tgene		C0156147	Crohn's disease of large bowel	1	CTD_human
Tgene		C0205696	Anaplastic carcinoma	1	CTD_human
Tgene		C0205697	Carcinoma, Spindle-Cell	1	CTD_human
Tgene		C0205698	Undifferentiated carcinoma	1	CTD_human
Tgene		C0205699	Carcinomatosis	1	CTD_human
Tgene		C0267380	Crohn's disease of the ileum	1	CTD_human
Tgene		C0334588	Giant Cell Glioblastoma	1	CTD_human
Tgene		C0345967	Malignant mesothelioma	1	CTD_human
Tgene		C0678202	Regional enteritis	1	CTD_human
Tgene		C0678222	Breast Carcinoma	1	CTD_human
Tgene		C0949272	IIeocolitis	1	CTD_human
Tgene		C1257925	Mammary Carcinoma, Animal	1	CTD_human
Tgene		C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene		C1458155	Mammary Neoplasms	1	CTD_human
Tgene		C1621958	Glioblastoma Multiforme	1	CTD_human
Tgene		C1866075	GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder)	1	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C3830362	Early Pregnancy Loss	1	CTD_human
Tgene		C3888104	Glomerulopathy with fibronectin deposits	1	CTD_human;ORPHANET
Tgene		C4552766	Miscarriage	1	CTD_human
Tgene		C4704874	Mammary Carcinoma, Human	1	CTD_human
Tgene		C4721507	Alveolitis, Fibrosing	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:DMD-FN1 (FusionGDB2 ID:HG1756TG2335)

Fusion Gene Summary for DMD-FN1

Fusion Gene ORF analysis for DMD-FN1

Fusion Genomic Features for DMD-FN1

Fusion Protein Features for DMD-FN1

Fusion Gene Sequence for DMD-FN1

Fusion Gene PPI Analysis for DMD-FN1

Related Drugs for DMD-FN1

Related Diseases for DMD-FN1

Fusion Gene Studies
in Kim Lab