Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DNMT3A-KIF3C (FusionGDB2 ID:HG1788TG3797)

Fusion Gene Summary for DNMT3A-KIF3C

check button Fusion gene summary
Fusion gene informationFusion gene name: DNMT3A-KIF3C
Fusion gene ID: hg1788tg3797
HgeneTgene
Gene symbol

DNMT3A

KIF3C

Gene ID

1788

3797

Gene nameDNA methyltransferase 3 alphakinesin family member 3C
SynonymsDNMT3A2|HESJAS|M.HsaIIIA|TBRS-
Cytomap('DNMT3A')('KIF3C')

2p23.3

2p23.3

Type of geneprotein-codingprotein-coding
DescriptionDNA (cytosine-5)-methyltransferase 3ADNA (cytosine-5-)-methyltransferase 3 alphaDNA MTase HsaIIIADNA cytosine methyltransferase 3A2kinesin-like protein KIF3CKIF3C variant protein
Modification date2020032220200313
UniProtAcc

Q9Y6K1

O14782

Ensembl transtripts involved in fusion geneENST00000264709, ENST00000321117, 
ENST00000406659, ENST00000380746, 
ENST00000402667, ENST00000474887, 
Fusion gene scores* DoF score8 X 10 X 7=5605 X 5 X 3=75
# samples 95
** MAII scorelog2(9/560*10)=-2.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNMT3A [Title/Abstract] AND KIF3C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNMT3A(25536781)-KIF3C(26152932), # samples:1
Anticipated loss of major functional domain due to fusion event.DNMT3A-KIF3C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNMT3A-KIF3C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNMT3A-KIF3C seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
DNMT3A-KIF3C seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
DNMT3A-KIF3C seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
DNMT3A-KIF3C seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
DNMT3A-KIF3C seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DNMT3A-KIF3C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNMT3A

GO:0006306

DNA methylation

12138111|19786833|23042785


check buttonFusion gene breakpoints across DNMT3A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across KIF3C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A925DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-


Top

Fusion Gene ORF analysis for DNMT3A-KIF3C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000264709ENST00000496378DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-
5CDS-5UTRENST00000321117ENST00000496378DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-
5CDS-5UTRENST00000406659ENST00000496378DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-
Frame-shiftENST00000264709ENST00000264712DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-
Frame-shiftENST00000264709ENST00000405914DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-
Frame-shiftENST00000406659ENST00000264712DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-
Frame-shiftENST00000406659ENST00000405914DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-
In-frameENST00000321117ENST00000264712DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-
In-frameENST00000321117ENST00000405914DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-
intron-3CDSENST00000380746ENST00000264712DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-
intron-3CDSENST00000380746ENST00000405914DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-
intron-3CDSENST00000402667ENST00000264712DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-
intron-3CDSENST00000402667ENST00000405914DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-
intron-3CDSENST00000474887ENST00000264712DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-
intron-3CDSENST00000474887ENST00000405914DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-
intron-5UTRENST00000380746ENST00000496378DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-
intron-5UTRENST00000402667ENST00000496378DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-
intron-5UTRENST00000474887ENST00000496378DNMT3Achr2

25536781

-KIF3Cchr2

26152932

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000321117DNMT3Achr225536781-ENST00000264712KIF3Cchr226152932-3061309280684134
ENST00000321117DNMT3Achr225536781-ENST00000405914KIF3Cchr226152932-910309280684134

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000321117ENST00000264712DNMT3Achr225536781-KIF3Cchr226152932-0.695334550.30466548
ENST00000321117ENST00000405914DNMT3Achr225536781-KIF3Cchr226152932-0.223291250.7767087

Top

Fusion Genomic Features for DNMT3A-KIF3C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for DNMT3A-KIF3C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:25536781/chr2:26152932)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNMT3A

Q9Y6K1

KIF3C

O14782

FUNCTION: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:30478443}.FUNCTION: Microtubule-based anterograde translocator for membranous organelles. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000264709-223292_35024913.0DomainPWWP
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000264709-223482_61424913.0DomainADD
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000264709-223634_91224913.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000321117-223292_35024913.0DomainPWWP
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000321117-223482_61424913.0DomainADD
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000321117-223634_91224913.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000380746-119292_3500724.0DomainPWWP
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000380746-119482_6140724.0DomainADD
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000380746-119634_9120724.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000402667-118292_3500690.0DomainPWWP
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000402667-118482_6140690.0DomainADD
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000402667-118634_9120690.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000406659-24292_35024167.0DomainPWWP
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000406659-24482_61424167.0DomainADD
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000406659-24634_91224167.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000264709-223641_64524913.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000264709-223686_68824913.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000264709-223891_89324913.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000321117-223641_64524913.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000321117-223686_68824913.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000321117-223891_89324913.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000380746-119641_6450724.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000380746-119686_6880724.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000380746-119891_8930724.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000402667-118641_6450690.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000402667-118686_6880690.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000402667-118891_8930690.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000406659-24641_64524167.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000406659-24686_68824167.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000406659-24891_89324167.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000264709-223493_52324913.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000264709-223534_59024913.0Zinc fingerPHD-type%3B atypical
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000321117-223493_52324913.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000321117-223534_59024913.0Zinc fingerPHD-type%3B atypical
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000380746-119493_5230724.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000380746-119534_5900724.0Zinc fingerPHD-type%3B atypical
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000402667-118493_5230690.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000402667-118534_5900690.0Zinc fingerPHD-type%3B atypical
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000406659-24493_52324167.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000406659-24534_59024167.0Zinc fingerPHD-type%3B atypical
TgeneKIF3Cchr2:25536781chr2:26152932ENST0000026471248376_629668794.0Coiled coilOntology_term=ECO:0000255
TgeneKIF3Cchr2:25536781chr2:26152932ENST0000040591459376_629668794.0Coiled coilOntology_term=ECO:0000255
TgeneKIF3Cchr2:25536781chr2:26152932ENST0000026471248270_284668794.0Compositional biasNote=Poly-Gly
TgeneKIF3Cchr2:25536781chr2:26152932ENST0000026471248438_441668794.0Compositional biasNote=Poly-Asn
TgeneKIF3Cchr2:25536781chr2:26152932ENST0000040591459270_284668794.0Compositional biasNote=Poly-Gly
TgeneKIF3Cchr2:25536781chr2:26152932ENST0000040591459438_441668794.0Compositional biasNote=Poly-Asn
TgeneKIF3Cchr2:25536781chr2:26152932ENST000002647124810_365668794.0DomainKinesin motor
TgeneKIF3Cchr2:25536781chr2:26152932ENST000004059145910_365668794.0DomainKinesin motor
TgeneKIF3Cchr2:25536781chr2:26152932ENST000002647124897_104668794.0Nucleotide bindingNote=ATP
TgeneKIF3Cchr2:25536781chr2:26152932ENST000004059145997_104668794.0Nucleotide bindingNote=ATP
TgeneKIF3Cchr2:25536781chr2:26152932ENST0000026471248630_793668794.0RegionGlobular
TgeneKIF3Cchr2:25536781chr2:26152932ENST0000040591459630_793668794.0RegionGlobular


Top

Fusion Gene Sequence for DNMT3A-KIF3C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23711_23711_1_DNMT3A-KIF3C_DNMT3A_chr2_25536781_ENST00000321117_KIF3C_chr2_26152932_ENST00000264712_length(transcript)=3061nt_BP=309nt
GACGCGGCGCCGCGGCACCAGGGCGCGCAGCCGGGCCGGCCCGACCCCACCGGCCATACGGTGGAGCCATCGAAGCCCCCACCCACAGGC
TGACAGAGGCACCGTTCACCAGAGGGCTCAACACCGGGATCTATGTTTAAGTTTTAACTCTCGCCTCCAAAGACCACGATAATTCCTTCC
CCAAAGCCCAGCAGCCCCCCAGCCCCGCGCAGCCCCAGCCTGCCTCCCGGCGCCCAGATGCCCGCCATGCCCTCCAGCGGCCCCGGGGAC
ACCAGCAGCTCTGCTGCGGAGCGGGAGGAGGACCGAAAGCAGTAGCAGCCAGATGAAGAAGCGGCCAACATCTGCAGTGGGCTACAAGAG
GCCTATCAGCCAGTATGCTCGGGTTGCCATGGCAATGGGGTCCCACCCCAGGTACAGGGCTGAAAACATAATGTTTCTGGAGTTGGATGT
GTCCCCTCCAGCTGTCTTTGAGATGGAATTCTCTCACGACCAAGAACAAGACCCTCGTGCGCTACACATGGAGAGGCTCATGCGATTGGA
CAGCTTTCTGGAAAGACCTTCCACGTCTAAAGTCCGAAAGTCCAGATCCTGGTGCCAGAGTCCTCAGCGGCCTCCACCTTCCACCACACA
TGCCTCCCTGGCCTCTGCTTCTCTGCGCCCTGCAACAGTGGCGGACCATGAGTGACAACCATCACGTCAGGCTGCCCATCCAATAGACTC
CTGGGATGGGGCAGCCAACCCTGGCTCATCTCATCTGCCGCTTGGTGCGTGTGCGTGTGCGTGCATGTGCGTGTGCGTGTGTGCAGGGGT
GAGAATCTGGCAGATGGTGCCTCTGCCTGCTCTTCTTCGCCTCCTTTATTTAATTCATGTTATTTATTCGCGGAGCTCTGTTCGTGTTGG
GGAGATGCCCTCGCCTGAGCCGTCTGGGCCTACCGTGGTCACTGCGTAGCCTCTTTTTCTTCTGACTTGAGAGCTCCCCCAGTCAGATCT
CAGGCTTGTCCCCCTGTCAGCTGCCTCCAGAAGGGAAGGTAGCCAGTGCCTGAGAAGACAGTCCCTTTTCTACCCACCGCACTCCATAAC
CTCCATCTTCTCCCACACTGATGGCGAGCAGCCCCTGAGCACTTTCTGGGACTGGGAGACTGCTTGGTGTTCCCTGAGGACAAGAGACAT
CCTGACAGTGTTGGGCATCTGCTCCCCGTGGACACAGCCCCACTCTCCACTTTCTGAGCCTCAGACAACCTCATTCAGCCTCTTGGGCTC
CTTTTCAAGGACATTAATAACCTCACCAACATAGCTCATGCCCTTCAGCTTTGACAAGAACTCACAGCTTCCCAAACTCTGCTTTCTGCC
CACCTTGGATGGGAACTGTGGACCAAGCAATTACCATCGCCTTGGAACCTGCAGGAAATGGAACAGCAATTGAGACAACTTGAACAGTCA
TCAACGGAAGTCCCTCCACTGGATTCCTTTGTTTCTGTCCCCTCCGAGGAGTCATTTTGGTCGACAGGCTCTCAAGGCAACTCCCCATTT
TCAAGAGGCTGCTCCTGCCTGCTTCGATCATTTCTCCCTGCAGCTGCCTAGACCCCGTTCACAGTGGGAGGAGTCAATGTCATTCTACCC
CTCGCTAAACGAAGATATTAACATCTATTGCTTTTTCCCTTCATCTGTCACAGGAAACAGAAGCCCAGGCACAATCTTTTCCAGCTTTGC
CTGTTACCCCTGTTTCTGAATTGCATCTTTAAGGTATTATTTTGTTGAAAATAGATCCTTTATTCACTAGTTACGCAAATTGGTTCCTAG
GGGGATACTCCTTACCTTCCTTTGTGATGGCCCAAAATGTCTCTAGGTATCTCAAGTGATAAGTAAATTTCTACAAAAAAAAATGGTTAA
TGTTCATTGACTGGCTTTTTAAGTGTATATTTTGGAGGACGGGTGAAGAGGTCATAACGAAAGCAAGCGAGTGAATTAGGATTTCAAAGT
GCCCTAATAGTGTGAGTCTCCAGTTCCTAGAATATGAAGAGTGCTGTCGTTGGGGTGAAACCATGAGACTGACAGATCTGCCTGAAATGG
GGGGTGTGGGAGGTGGTGGCGGGGGTTATTCTCTTTCCTTCAGGAAATGAACCCTTCTTACATCATTCAAGTTCTGCTCTGAGGATCAAG
CTTGGGTCTGATTTAACTCAGCGACACTGTCATTTCTGCTTCATTACTGGACTAGAGGGTTGAGCCACCCACTTGCCATTTGCTCCTGTC
CTTCCAGGAAATCACAATTTTCATCAGAGCCCAAGAGATTATTTGAGACTCAGGATTCAGATCAGAGGTTCGACTGTGGCTGGGACAGGA
GTTGTGTGTAGAAATTCACCAGGTGGCCTGAGCGCAGGGGGACCTCCAGGGCTGCGTTGAGCAGCCTCTCCCACTGACCTCTTTCTCGTT
TGTGGACAAAGCAGCACGTATCACCTCATTCATCACTTGGACACATCGCCTTTGCATTGTCTTGTCACACCTCCCTCACAGTCTTATAGC
ACAATATACCCAAATCAGCCCCCCCAGTCCGAGGGCTGGGCCCGAGGTATGGTCGGAGGAGGAGCTCCTGCCTGCGGTTTTGTGTATGTG
TGTATGTGTGTGCGTGTTTGTGTGCGTGTTTACCTCCACAGGGGACACTCTACACTCAGTGTAAGATCTGCTGGGAACAGGGCCACCAGG
AGTGGCTGGATCTCAGTCTCTCTGTCTCTCTTTCTCTCCTTTTCCTTTTGGTGTATCAAATATTTGATTGACAAAGTAAGGGCCTTGATT
AGGACCAAATTCTCGTGTGTTGCTATGGTCTTTATTTAGGACAACAATTAACAATGCAGTGGCCCATTCTTGTCACTCTACACATATGAC
TATACGGGACATATGTAATATATAAATATATATATAAAACATTCCCCTCTGTCCCCTTGGCTTCGGATGGAGGCCTTTCTGTTGAGCTGA
AATGCACCTGCAGCTGGGTGCTGCCAGCAGCTTGCAGGCCCCAGCCCTGTTCCAATCAATGCAGTTGACAATAAAGGAATGAGTATCGTC

>23711_23711_1_DNMT3A-KIF3C_DNMT3A_chr2_25536781_ENST00000321117_KIF3C_chr2_26152932_ENST00000264712_length(amino acids)=134AA_BP=9
MLRSGRRTESSSSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRYRAENIMFLELDVSPPAVFEMEFSHDQEQDPRALHMERLMRLDSFL

--------------------------------------------------------------
>23711_23711_2_DNMT3A-KIF3C_DNMT3A_chr2_25536781_ENST00000321117_KIF3C_chr2_26152932_ENST00000405914_length(transcript)=910nt_BP=309nt
GACGCGGCGCCGCGGCACCAGGGCGCGCAGCCGGGCCGGCCCGACCCCACCGGCCATACGGTGGAGCCATCGAAGCCCCCACCCACAGGC
TGACAGAGGCACCGTTCACCAGAGGGCTCAACACCGGGATCTATGTTTAAGTTTTAACTCTCGCCTCCAAAGACCACGATAATTCCTTCC
CCAAAGCCCAGCAGCCCCCCAGCCCCGCGCAGCCCCAGCCTGCCTCCCGGCGCCCAGATGCCCGCCATGCCCTCCAGCGGCCCCGGGGAC
ACCAGCAGCTCTGCTGCGGAGCGGGAGGAGGACCGAAAGCAGTAGCAGCCAGATGAAGAAGCGGCCAACATCTGCAGTGGGCTACAAGAG
GCCTATCAGCCAGTATGCTCGGGTTGCCATGGCAATGGGGTCCCACCCCAGGTACAGGGCTGAAAACATAATGTTTCTGGAGTTGGATGT
GTCCCCTCCAGCTGTCTTTGAGATGGAATTCTCTCACGACCAAGAACAAGACCCTCGTGCGCTACACATGGAGAGGCTCATGCGATTGGA
CAGCTTTCTGGAAAGACCTTCCACGTCTAAAGTCCGAAAGTCCAGATCCTGGTGCCAGAGTCCTCAGCGGCCTCCACCTTCCACCACACA
TGCCTCCCTGGCCTCTGCTTCTCTGCGCCCTGCAACAGTGGCGGACCATGAGTGACAACCATCACGTCAGGCTGCCCATCCAATAGACTC
CTGGGATGGGGCAGCCAACCCTGGCTCATCTCATCTGCCGCTTGGTGCGTGTGCGTGTGCGTGCATGTGCGTGTGCGTGTGTGCAGGGGT
GAGAATCTGGCAGATGGTGCCTCTGCCTGCTCTTCTTCGCCTCCTTTATTTAATTCATGTTATTTATTCGCGGAGCTCTGTTCGTGTTGG

>23711_23711_2_DNMT3A-KIF3C_DNMT3A_chr2_25536781_ENST00000321117_KIF3C_chr2_26152932_ENST00000405914_length(amino acids)=134AA_BP=9
MLRSGRRTESSSSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRYRAENIMFLELDVSPPAVFEMEFSHDQEQDPRALHMERLMRLDSFL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DNMT3A-KIF3C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000264709-223199_40324.0913.0DNMT1 and DNMT3B
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000321117-223199_40324.0913.0DNMT1 and DNMT3B
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000380746-119199_4030724.0DNMT1 and DNMT3B
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000402667-118199_4030690.0DNMT1 and DNMT3B
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000406659-24199_40324.0167.0DNMT1 and DNMT3B
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000264709-223494_58624.0913.0the PRC2/EED-EZH2 complex
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000321117-223494_58624.0913.0the PRC2/EED-EZH2 complex
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000380746-119494_5860724.0the PRC2/EED-EZH2 complex
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000402667-118494_5860690.0the PRC2/EED-EZH2 complex
HgeneDNMT3Achr2:25536781chr2:26152932ENST00000406659-24494_58624.0167.0the PRC2/EED-EZH2 complex


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DNMT3A-KIF3C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneDNMT3AQ9Y6K1DB01262DecitabineInhibitorSmall moleculeApproved|Investigational
HgeneDNMT3AQ9Y6K1DB00721ProcaineInhibitorSmall moleculeApproved|Investigational|Vet_approved

Top

Related Diseases for DNMT3A-KIF3C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNMT3AC4014545Tatton Brown Rahman syndrome4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneDNMT3AC0018273Growth Disorders2CTD_human
HgeneDNMT3AC0079774Peripheral T-Cell Lymphoma2CTD_human
HgeneDNMT3AC0006142Malignant neoplasm of breast1CTD_human
HgeneDNMT3AC0010346Crohn Disease1CTD_human
HgeneDNMT3AC0013336Dwarfism1CTD_human
HgeneDNMT3AC0020796Profound Mental Retardation1CTD_human
HgeneDNMT3AC0020981Angioimmunoblastic Lymphadenopathy1CTD_human
HgeneDNMT3AC0023465Acute monocytic leukemia1CTD_human
HgeneDNMT3AC0023487Acute Promyelocytic Leukemia1CTD_human
HgeneDNMT3AC0024121Lung Neoplasms1CTD_human
HgeneDNMT3AC0025363Mental Retardation, Psychosocial1CTD_human
HgeneDNMT3AC0025958Microcephaly1CTD_human
HgeneDNMT3AC0027643Neoplasm Recurrence, Local1CTD_human
HgeneDNMT3AC0036920Sezary Syndrome1CTD_human
HgeneDNMT3AC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
HgeneDNMT3AC0156147Crohn's disease of large bowel1CTD_human
HgeneDNMT3AC0242379Malignant neoplasm of lung1CTD_human
HgeneDNMT3AC0265202Seckel syndrome1GENOMICS_ENGLAND
HgeneDNMT3AC0267380Crohn's disease of the ileum1CTD_human
HgeneDNMT3AC0282631Facies1CTD_human
HgeneDNMT3AC0349639Juvenile Myelomonocytic Leukemia1CTD_human
HgeneDNMT3AC0376407Granulomatous Slack Skin1CTD_human
HgeneDNMT3AC0376634Craniofacial Abnormalities1CTD_human
HgeneDNMT3AC0678202Regional enteritis1CTD_human
HgeneDNMT3AC0678222Breast Carcinoma1CTD_human
HgeneDNMT3AC0917816Mental deficiency1CTD_human
HgeneDNMT3AC0949272IIeocolitis1CTD_human
HgeneDNMT3AC1257931Mammary Neoplasms, Human1CTD_human
HgeneDNMT3AC1458155Mammary Neoplasms1CTD_human
HgeneDNMT3AC1510586Autism Spectrum Disorders1CTD_human
HgeneDNMT3AC1956147Microlissencephaly1CTD_human
HgeneDNMT3AC2931852Clear-cell metastatic renal cell carcinoma1CTD_human
HgeneDNMT3AC3496069cocaine use1PSYGENET
HgeneDNMT3AC3714756Intellectual Disability1CTD_human
HgeneDNMT3AC3853041Severe Congenital Microcephaly1CTD_human
HgeneDNMT3AC4704874Mammary Carcinoma, Human1CTD_human
TgeneC0004238Atrial Fibrillation2CTD_human
TgeneC0235480Paroxysmal atrial fibrillation2CTD_human
TgeneC2585653Persistent atrial fibrillation2CTD_human
TgeneC3468561familial atrial fibrillation2CTD_human
TgeneC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human