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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:DNMT3B-DUSP15 (FusionGDB2 ID:HG1789TG128853)

Fusion Gene Summary for DNMT3B-DUSP15

check button Fusion gene summary
Fusion gene informationFusion gene name: DNMT3B-DUSP15
Fusion gene ID: hg1789tg128853
HgeneTgene
Gene symbol

DNMT3B

DUSP15

Gene ID

1789

128853

Gene nameDNA methyltransferase 3 betadual specificity phosphatase 15
SynonymsICF|ICF1|M.HsaIIIBC20orf57|VHY
Cytomap('DNMT3B')('DUSP15')

20q11.21

20q11.21

Type of geneprotein-codingprotein-coding
DescriptionDNA (cytosine-5)-methyltransferase 3BDNA (cytosine-5-)-methyltransferase 3 betaDNA MTase HsaIIIBDNA cytosine-5--methyltransferase 3 betaDNA methyltransferase HsaIIIBdual specificity protein phosphatase 15VH1-related member Ydual specificity phosphatase-like 15vaccinia virus VH1-related dual-specific protein phosphatase Y
Modification date2020031320200313
UniProtAcc

Q9UBC3

.
Ensembl transtripts involved in fusion geneENST00000201963, ENST00000328111, 
ENST00000344505, ENST00000348286, 
ENST00000353855, ENST00000375623, 
ENST00000443239, ENST00000456297, 
Fusion gene scores* DoF score7 X 7 X 5=2455 X 3 X 4=60
# samples 85
** MAII scorelog2(8/245*10)=-1.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNMT3B [Title/Abstract] AND DUSP15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNMT3B(31376818)-DUSP15(30457400), # samples:3
Anticipated loss of major functional domain due to fusion event.DNMT3B-DUSP15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNMT3B-DUSP15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNMT3B-DUSP15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNMT3B-DUSP15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNMT3B

GO:0000122

negative regulation of transcription by RNA polymerase II

17303076

TgeneDUSP15

GO:0016311

dephosphorylation

24531476


check buttonFusion gene breakpoints across DNMT3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DUSP15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-K4-A3WS-01ADNMT3Bchr20

31376818

-DUSP15chr20

30457400

-
ChimerDB4BLCATCGA-K4-A3WS-01ADNMT3Bchr20

31376818

+DUSP15chr20

30457400

-


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Fusion Gene ORF analysis for DNMT3B-DUSP15

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000201963ENST00000339738DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000201963ENST00000375966DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000201963ENST00000398083DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000201963ENST00000398084DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000201963ENST00000486996DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000201963ENST00000493115DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000328111ENST00000339738DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000328111ENST00000375966DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000328111ENST00000398083DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000328111ENST00000398084DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000328111ENST00000486996DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000328111ENST00000493115DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000344505ENST00000339738DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000344505ENST00000375966DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000344505ENST00000398083DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000344505ENST00000398084DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000344505ENST00000486996DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000344505ENST00000493115DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000348286ENST00000339738DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000348286ENST00000375966DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000348286ENST00000398083DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000348286ENST00000398084DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000348286ENST00000486996DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000348286ENST00000493115DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000353855ENST00000339738DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000353855ENST00000375966DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000353855ENST00000398083DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000353855ENST00000398084DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000353855ENST00000486996DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000353855ENST00000493115DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000375623ENST00000339738DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000375623ENST00000375966DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000375623ENST00000398083DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000375623ENST00000398084DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000375623ENST00000486996DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000375623ENST00000493115DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000443239ENST00000339738DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000443239ENST00000375966DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000443239ENST00000398083DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000443239ENST00000398084DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000443239ENST00000486996DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000443239ENST00000493115DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000456297ENST00000339738DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000456297ENST00000375966DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000456297ENST00000398083DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000456297ENST00000398084DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000456297ENST00000486996DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
5CDS-5UTRENST00000456297ENST00000493115DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
In-frameENST00000201963ENST00000278979DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
In-frameENST00000328111ENST00000278979DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
In-frameENST00000344505ENST00000278979DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
In-frameENST00000348286ENST00000278979DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
In-frameENST00000353855ENST00000278979DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
In-frameENST00000375623ENST00000278979DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
In-frameENST00000443239ENST00000278979DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-
In-frameENST00000456297ENST00000278979DNMT3Bchr20

31376818

+DUSP15chr20

30457400

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000328111DNMT3Bchr2031376818+ENST00000278979DUSP15chr2030457400-277711341172009630
ENST00000348286DNMT3Bchr2031376818+ENST00000278979DUSP15chr2030457400-27381095781970630
ENST00000353855DNMT3Bchr2031376818+ENST00000278979DUSP15chr2030457400-27381095781970630
ENST00000443239DNMT3Bchr2031376818+ENST00000278979DUSP15chr2030457400-2440797951672525
ENST00000344505DNMT3Bchr2031376818+ENST00000278979DUSP15chr2030457400-2553910821785567
ENST00000375623DNMT3Bchr2031376818+ENST00000278979DUSP15chr2030457400-2418775731650525
ENST00000456297DNMT3Bchr2031376818+ENST00000278979DUSP15chr2030457400-2292649491524491
ENST00000201963DNMT3Bchr2031376818+ENST00000278979DUSP15chr2030457400-275611132191988589

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000328111ENST00000278979DNMT3Bchr2031376818+DUSP15chr2030457400-0.0881693140.91183066
ENST00000348286ENST00000278979DNMT3Bchr2031376818+DUSP15chr2030457400-0.089927930.91007215
ENST00000353855ENST00000278979DNMT3Bchr2031376818+DUSP15chr2030457400-0.089927930.91007215
ENST00000443239ENST00000278979DNMT3Bchr2031376818+DUSP15chr2030457400-0.08919410.9108059
ENST00000344505ENST00000278979DNMT3Bchr2031376818+DUSP15chr2030457400-0.0837438550.9162561
ENST00000375623ENST00000278979DNMT3Bchr2031376818+DUSP15chr2030457400-0.087504520.91249543
ENST00000456297ENST00000278979DNMT3Bchr2031376818+DUSP15chr2030457400-0.147181170.8528188
ENST00000201963ENST00000278979DNMT3Bchr2031376818+DUSP15chr2030457400-0.0678449350.9321551

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Fusion Genomic Features for DNMT3B-DUSP15


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DNMT3B-DUSP15


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:31376818/chr20:30457400)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNMT3B

Q9UBC3

.
FUNCTION: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398). {ECO:0000250, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:17303076, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18567530, ECO:0000269|PubMed:27153398}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+722225_283283846.0DomainPWWP
TgeneDUSP15chr20:31376818chr20:30457400ENST000002789790101_1414296.0DomainTyrosine-protein phosphatase
TgeneDUSP15chr20:31376818chr20:30457400ENST00000375966071_1414233.0DomainTyrosine-protein phosphatase
TgeneDUSP15chr20:31376818chr20:30457400ENST00000398083071_1410133.0DomainTyrosine-protein phosphatase
TgeneDUSP15chr20:31376818chr20:30457400ENST00000398084071_1410133.0DomainTyrosine-protein phosphatase
TgeneDUSP15chr20:31376818chr20:30457400ENST00000486996061_1410133.0DomainTyrosine-protein phosphatase

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+722423_555283846.0DomainADD
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+722575_853283846.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+723225_283271854.0DomainPWWP
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+723423_555271854.0DomainADD
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+723575_853271854.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+721225_283271793.0DomainPWWP
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+721423_555271793.0DomainADD
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+721575_853271793.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+720225_283271771.0DomainPWWP
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+720423_555271771.0DomainADD
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+720575_853271771.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+722225_283271834.0DomainPWWP
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+722423_555271834.0DomainADD
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+722575_853271834.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+619225_283229729.0DomainPWWP
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+619423_555229729.0DomainADD
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+619575_853229729.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+518225_283195695.0DomainPWWP
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+518423_555195695.0DomainADD
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+518575_853195695.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+722582_586283846.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+722627_629283846.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+722832_834283846.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+723582_586271854.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+723627_629271854.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+723832_834271854.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+721582_586271793.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+721627_629271793.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+721832_834271793.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+720582_586271771.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+720627_629271771.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+720832_834271771.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+722582_586271834.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+722627_629271834.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+722832_834271834.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+619582_586229729.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+619627_629229729.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+619832_834229729.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+518582_586195695.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+518627_629195695.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+518832_834195695.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+722434_464283846.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+722475_531283846.0Zinc fingerPHD-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+723434_464271854.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+723475_531271854.0Zinc fingerPHD-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+721434_464271793.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+721475_531271793.0Zinc fingerPHD-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+720434_464271771.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+720475_531271771.0Zinc fingerPHD-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+722434_464271834.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+722475_531271834.0Zinc fingerPHD-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+619434_464229729.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+619475_531229729.0Zinc fingerPHD-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+518434_464195695.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+518475_531195695.0Zinc fingerPHD-type%3B atypical
TgeneDUSP15chr20:31376818chr20:30457400ENST00000339738071_1417236.0DomainTyrosine-protein phosphatase


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Fusion Gene Sequence for DNMT3B-DUSP15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23716_23716_1_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000201963_DUSP15_chr20_30457400_ENST00000278979_length(transcript)=2756nt_BP=1113nt
GAAGGGAGAGAGCAAACAAAGGGGTCAGGAGGGAAAATAATGCACTGGCTTCCTGAGCCCCTGCAGAGGCTGAGCAGGGAGAGGGGGCCA
GGGCCAGAGGGGACAGAGGCTGGCGGCAGACGGGCCGGGACAGGCAGGTCCTAAATGGCATTGTTTGAAGGGGCCGGCTAATTGCACAGA
GCAGTCTGAGCCTGAGACCCCAGCCCTGGCCTCCCCACTCTGTCCTGGGTGCTGGCGTCTGAGCCTTCGGGACAGCCTGTCCACATGGAA
CCAAGTCCTGAGCCTCCAAGCTTGGAAAGCATGAAGGGAGACACCAGGCATCTCAATGGAGAGGAGGACGCCGGCGGGAGGGAAGACTCG
ATCCTCGTCAACGGGGCCTGCAGCGACCAGTCCTCCGACTCGCCCCCAATCCTGGAGGCTATCCGCACCCCGGAGATCAGAGGCCGAAGA
TCAAGCTCGCGACTCTCCAAGAGGGAGGTGTCCAGTCTGCTAAGCTACACACAGGACTTGACAGGCGATGGCGACGGGGAAGATGGGGAT
GGCTCTGACACCCCAGTCATGCCAAAGCTCTTCCGGGAAACCAGGACTCGTTCAGAAAGCCCAGCTGTCCGAACTCGAAATAACAACAGT
GTCTCCAGCCGGGAGAGGCACAGGCCTTCCCCACGTTCCACCCGAGGCCGGCAGGGCCGCAACCATGTGGACGAGTCCCCCGTGGAGTTC
CCGGCTACCAGGTCCCTGAGACGGCGGGCAACAGCATCGGCAGGAACGCCATGGCCGTCCCCTCCCAGCTCTTACCTTACCATCGACCTC
ACAGACGACACAGAGGACACACATGGGACGCCCCAGAGCAGCAGTACCCCCTACGCCCGCCTAGCCCAGGACAGCCAGCAGGGGGGCATG
GAGTCCCCGCAGGTGGAGGCAGACAGTGGAGATGGAGACAGTTCAGAGTATCAGGATGGGAAGGAGTTTGGAATAGGGGACCTCGTGTGG
GGAAAGATCAAGGGCTTCTCCTGGTGGCCCGCCATGGTGGTGTCTTGGAAGGCCACCTCCAAGCGACAGGCTATGTCTGGCATGCGGTGG
GTCCAGTGGTTTGGCGATGGCAAGTTCTCCGAGGTACTTCCTGGACTCTACCTCGGAAACTTCATTGATGCCAAAGACCTGGATCAGCTG
GGCCGAAATAAGATCACACACATCATCTCTATCCATGAGTCACCCCAGCCTCTGCTGCAGGATATCACCTACCTTCGCATCCCGGTCGCT
GATACCCCTGAGGTACCCATCAAAAAGCACTTCAAAGAATGTATCAACTTCATCCACTGCTGCCGCCTTAATGGGGGGAACTGCCTTGTG
CACTGCTTTGCAGGCATCTCTCGCAGCACCACGATTGTGACAGCGTATGTGATGACTGTGACGGGGCTAGGCTGGCGGGACGTGCTTGAA
GCCATCAAGGCCACCAGGCCCATCGCCAACCCCAACCCAGGCTTTAGGCAGCAGCTTGAAGAGTTTGGCTGGGCCAGTTCCCAGAAGGGT
GCCAGACATAGGACCTCAAAAACCTCTGGTGCCCAATGCCCTCCGATGACTTCAGCAACCTGCCTGCTGGCTGCACGTGTGGCTCTTCTC
TCCGCAGCGCTGGTGCGCGAAGCCACCGGGCGCACAGCCCAGCGCTGTCGTCTGAGTCCGCGGGCGGCCGCCGAGCGCCTGCTGGGGCCG
CCACCTCACGTTGCAGCAGGATGGTCACCGGACCCAAAGTACCAGATCTGTCTGTGCTTCGGTGAGGAGGACCCGGGCCCCACACAGCAC
CCCAAGGAGCAGCTCATCATGGCGGACGTGCAGGTGCAGCTTCGGCCTGGGAGCTCGTCCTGCACTCTAAGTGCCTCAACCGAGCGCCCA
GATGGGTCCTCAACCCCTGGCAACCCCGATGGCATCACTCACCTTCAATGCAGCTGCCTCCATCCTAAGCGAGCCGCTTCCTCTTCTTGT
ACCCGCTGAAGGCAGCCCCCAACAGGGGGGCTCCCTACTCCCACCCAACCCTGCCCACACTAAGCCCATAGACTTGGGGCCTCCCCCGGC
ACATCACCCAGGTCTGCCGGACGGCAGAGGTGGATCGCGGCCTTCCACTCCTCTGTCACGGGGCCCCGGAACTCGAGAGTAGGCCACACC
GCCCCCCAGCTGGGCATGGGGCTTCGGCAGGAAACTGAACTTGATCTTGAGGCCCCAGAAAGGCAGCAACTGGAGCAGAAGCAAGACTTC
ATCTCTTGCTGACAGCCCAATTTGTCAATAGCGCTTTCCTCAGAGCCAGCCTTAACCTGCTGTTGAGTCCATTAAAACGTTTGCTTAAAG
TTTTTACCAATAATTAGATCATCAGGGTTGTTTAGTGTGGGATCAAGCCATAACAAAACTGCCTAGCCTCTCAGGGGCCTAGAATTTACA
GAACCTTCCTCCTCCCTGCAGCTAGTCTCTCTTCTTTATTCTGGGGGCTGGGAAGGATCCCAAAACAGGGAACTTGGCCGAACCCTGGGC
TTTGGATGCTAACCACTGAAGTACCAGCACCTGTAGGATGCTGTCTTTGAAGAAACTGAGGCGGACCTCCAAATGCAGCCCTAAGGCAGA
GGTCAACGTGGAAGACCAGCCCTTCTCCAAGCCCCACTGGTCTTTGCAAGCTGTACGTTGTAGGCAATCTGAGAACTGGAAAGGGGGACT

>23716_23716_1_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000201963_DUSP15_chr20_30457400_ENST00000278979_length(amino acids)=589AA_BP=298
MSWVLASEPSGQPVHMEPSPEPPSLESMKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSL
LSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATAS
AGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMV
VSWKATSKRQAMSGMRWVQWFGDGKFSEVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKE
CINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQC
PPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQ

--------------------------------------------------------------
>23716_23716_2_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000328111_DUSP15_chr20_30457400_ENST00000278979_length(transcript)=2777nt_BP=1134nt
ACCCACTCCCGCTGCCCCGTCCGGCCCGCGCCGCTTCCTCGCAGCAGCTGCTCCCGGCTCCGCGGCCGCAGCCCGCGTGGACGCTCCGAG
CGCCCCCCGACGGACGGGACCGGCTCCCTGGCGGTCGGGCGAGCGGGCGGCAACGCTGCCCGGCCGGCAGCGCTGGGGTTAAGTGGCCCA
AGTAAACCTAGCTCGGCGATCGGCGCCGGAGATTCGCGAGCCCAGCGCCCTGCACGGCCGCCAGCCGGCCTCCCGCCAGCCAGCCCCGAC
CCGCGGCTCCGCCGCCCAGCCGCGCCCCAGCCAGCCCTGCGGCAGGAAAGCATGAAGGGAGACACCAGGCATCTCAATGGAGAGGAGGAC
GCCGGCGGGAGGGAAGACTCGATCCTCGTCAACGGGGCCTGCAGCGACCAGTCCTCCGACTCGCCCCCAATCCTGGAGGCTATCCGCACC
CCGGAGATCAGAGGCCGAAGATCAAGCTCGCGACTCTCCAAGAGGGAGGTGTCCAGTCTGCTAAGCTACACACAGGACTTGACAGGCGAT
GGCGACGGGGAAGATGGGGATGGCTCTGACACCCCAGTCATGCCAAAGCTCTTCCGGGAAACCAGGACTCGTTCAGAAAGCCCAGCTGTC
CGAACTCGAAATAACAACAGTGTCTCCAGCCGGGAGAGGCACAGGCCTTCCCCACGTTCCACCCGAGGCCGGCAGGGCCGCAACCATGTG
GACGAGTCCCCCGTGGAGTTCCCGGCTACCAGGTCCCTGAGACGGCGGGCAACAGCATCGGCAGGAACGCCATGGCCGTCCCCTCCCAGC
TCTTACCTTACCATCGACCTCACAGACGACACAGAGGACACACATGGGACGCCCCAGAGCAGCAGTACCCCCTACGCCCGCCTAGCCCAG
GACAGCCAGCAGGGGGGCATGGAGTCCCCGCAGGTGGAGGCAGACAGTGGAGATGGAGACAGTTCAGAGTATCAGGATGGGAAGGAGTTT
GGAATAGGGGACCTCGTGTGGGGAAAGATCAAGGGCTTCTCCTGGTGGCCCGCCATGGTGGTGTCTTGGAAGGCCACCTCCAAGCGACAG
GCTATGTCTGGCATGCGGTGGGTCCAGTGGTTTGGCGATGGCAAGTTCTCCGAGGTACTTCCTGGACTCTACCTCGGAAACTTCATTGAT
GCCAAAGACCTGGATCAGCTGGGCCGAAATAAGATCACACACATCATCTCTATCCATGAGTCACCCCAGCCTCTGCTGCAGGATATCACC
TACCTTCGCATCCCGGTCGCTGATACCCCTGAGGTACCCATCAAAAAGCACTTCAAAGAATGTATCAACTTCATCCACTGCTGCCGCCTT
AATGGGGGGAACTGCCTTGTGCACTGCTTTGCAGGCATCTCTCGCAGCACCACGATTGTGACAGCGTATGTGATGACTGTGACGGGGCTA
GGCTGGCGGGACGTGCTTGAAGCCATCAAGGCCACCAGGCCCATCGCCAACCCCAACCCAGGCTTTAGGCAGCAGCTTGAAGAGTTTGGC
TGGGCCAGTTCCCAGAAGGGTGCCAGACATAGGACCTCAAAAACCTCTGGTGCCCAATGCCCTCCGATGACTTCAGCAACCTGCCTGCTG
GCTGCACGTGTGGCTCTTCTCTCCGCAGCGCTGGTGCGCGAAGCCACCGGGCGCACAGCCCAGCGCTGTCGTCTGAGTCCGCGGGCGGCC
GCCGAGCGCCTGCTGGGGCCGCCACCTCACGTTGCAGCAGGATGGTCACCGGACCCAAAGTACCAGATCTGTCTGTGCTTCGGTGAGGAG
GACCCGGGCCCCACACAGCACCCCAAGGAGCAGCTCATCATGGCGGACGTGCAGGTGCAGCTTCGGCCTGGGAGCTCGTCCTGCACTCTA
AGTGCCTCAACCGAGCGCCCAGATGGGTCCTCAACCCCTGGCAACCCCGATGGCATCACTCACCTTCAATGCAGCTGCCTCCATCCTAAG
CGAGCCGCTTCCTCTTCTTGTACCCGCTGAAGGCAGCCCCCAACAGGGGGGCTCCCTACTCCCACCCAACCCTGCCCACACTAAGCCCAT
AGACTTGGGGCCTCCCCCGGCACATCACCCAGGTCTGCCGGACGGCAGAGGTGGATCGCGGCCTTCCACTCCTCTGTCACGGGGCCCCGG
AACTCGAGAGTAGGCCACACCGCCCCCCAGCTGGGCATGGGGCTTCGGCAGGAAACTGAACTTGATCTTGAGGCCCCAGAAAGGCAGCAA
CTGGAGCAGAAGCAAGACTTCATCTCTTGCTGACAGCCCAATTTGTCAATAGCGCTTTCCTCAGAGCCAGCCTTAACCTGCTGTTGAGTC
CATTAAAACGTTTGCTTAAAGTTTTTACCAATAATTAGATCATCAGGGTTGTTTAGTGTGGGATCAAGCCATAACAAAACTGCCTAGCCT
CTCAGGGGCCTAGAATTTACAGAACCTTCCTCCTCCCTGCAGCTAGTCTCTCTTCTTTATTCTGGGGGCTGGGAAGGATCCCAAAACAGG
GAACTTGGCCGAACCCTGGGCTTTGGATGCTAACCACTGAAGTACCAGCACCTGTAGGATGCTGTCTTTGAAGAAACTGAGGCGGACCTC
CAAATGCAGCCCTAAGGCAGAGGTCAACGTGGAAGACCAGCCCTTCTCCAAGCCCCACTGGTCTTTGCAAGCTGTACGTTGTAGGCAATC

>23716_23716_2_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000328111_DUSP15_chr20_30457400_ENST00000278979_length(amino acids)=630AA_BP=339
MAVGRAGGNAARPAALGLSGPSKPSSAIGAGDSRAQRPARPPAGLPPASPDPRLRRPAAPQPALRQESMKGDTRHLNGEEDAGGREDSIL
VNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVS
SRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMES
PQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVLPGLYLGNFIDAKDLDQLGR
NKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAI
KATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPP
HVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQLRPGSSSCTLSASTERPDGSSTPGNPDGITHLQCSCLHPKRAASSSCTR

--------------------------------------------------------------
>23716_23716_3_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000344505_DUSP15_chr20_30457400_ENST00000278979_length(transcript)=2553nt_BP=910nt
GCGCCCTGCACGGCCGCCAGCCGGCCTCCCGCCAGCCAGCCCCGACCCGCGGCTCCGCCGCCCAGCCGCGCCCCAGCCAGCCCTGCGGCA
GGAAAGCATGAAGGGAGACACCAGGCATCTCAATGGAGAGGAGGACGCCGGCGGGAGGGAAGACTCGATCCTCGTCAACGGGGCCTGCAG
CGACCAGTCCTCCGACTCGCCCCCAATCCTGGAGGCTATCCGCACCCCGGAGATCAGAGGCCGAAGATCAAGCTCGCGACTCTCCAAGAG
GGAGGTGTCCAGTCTGCTAAGCTACACACAGGACTTGACAGGCGATGGCGACGGGGAAGATGGGGATGGCTCTGACACCCCAGTCATGCC
AAAGCTCTTCCGGGAAACCAGGACTCGTTCAGAAAGCCCAGCTGTCCGAACTCGAAATAACAACAGTGTCTCCAGCCGGGAGAGGCACAG
GCCTTCCCCACGTTCCACCCGAGGCCGGCAGGGCCGCAACCATGTGGACGAGTCCCCCGTGGAGTTCCCGGCTACCAGGTCCCTGAGACG
GCGGGCAACAGCATCGGCAGGAACGCCATGGCCGTCCCCTCCCAGCTCTTACCTTACCATCGACCTCACAGACGACACAGAGGACACACA
TGGGACGCCCCAGAGCAGCAGTACCCCCTACGCCCGCCTAGCCCAGGACAGCCAGCAGGGGGGCATGGAGTCCCCGCAGGTGGAGGCAGA
CAGTGGAGATGGAGACAGTTCAGAGTATCAGGATGGGAAGGAGTTTGGAATAGGGGACCTCGTGTGGGGAAAGATCAAGGGCTTCTCCTG
GTGGCCCGCCATGGTGGTGTCTTGGAAGGCCACCTCCAAGCGACAGGCTATGTCTGGCATGCGGTGGGTCCAGTGGTTTGGCGATGGCAA
GTTCTCCGAGGTACTTCCTGGACTCTACCTCGGAAACTTCATTGATGCCAAAGACCTGGATCAGCTGGGCCGAAATAAGATCACACACAT
CATCTCTATCCATGAGTCACCCCAGCCTCTGCTGCAGGATATCACCTACCTTCGCATCCCGGTCGCTGATACCCCTGAGGTACCCATCAA
AAAGCACTTCAAAGAATGTATCAACTTCATCCACTGCTGCCGCCTTAATGGGGGGAACTGCCTTGTGCACTGCTTTGCAGGCATCTCTCG
CAGCACCACGATTGTGACAGCGTATGTGATGACTGTGACGGGGCTAGGCTGGCGGGACGTGCTTGAAGCCATCAAGGCCACCAGGCCCAT
CGCCAACCCCAACCCAGGCTTTAGGCAGCAGCTTGAAGAGTTTGGCTGGGCCAGTTCCCAGAAGGGTGCCAGACATAGGACCTCAAAAAC
CTCTGGTGCCCAATGCCCTCCGATGACTTCAGCAACCTGCCTGCTGGCTGCACGTGTGGCTCTTCTCTCCGCAGCGCTGGTGCGCGAAGC
CACCGGGCGCACAGCCCAGCGCTGTCGTCTGAGTCCGCGGGCGGCCGCCGAGCGCCTGCTGGGGCCGCCACCTCACGTTGCAGCAGGATG
GTCACCGGACCCAAAGTACCAGATCTGTCTGTGCTTCGGTGAGGAGGACCCGGGCCCCACACAGCACCCCAAGGAGCAGCTCATCATGGC
GGACGTGCAGGTGCAGCTTCGGCCTGGGAGCTCGTCCTGCACTCTAAGTGCCTCAACCGAGCGCCCAGATGGGTCCTCAACCCCTGGCAA
CCCCGATGGCATCACTCACCTTCAATGCAGCTGCCTCCATCCTAAGCGAGCCGCTTCCTCTTCTTGTACCCGCTGAAGGCAGCCCCCAAC
AGGGGGGCTCCCTACTCCCACCCAACCCTGCCCACACTAAGCCCATAGACTTGGGGCCTCCCCCGGCACATCACCCAGGTCTGCCGGACG
GCAGAGGTGGATCGCGGCCTTCCACTCCTCTGTCACGGGGCCCCGGAACTCGAGAGTAGGCCACACCGCCCCCCAGCTGGGCATGGGGCT
TCGGCAGGAAACTGAACTTGATCTTGAGGCCCCAGAAAGGCAGCAACTGGAGCAGAAGCAAGACTTCATCTCTTGCTGACAGCCCAATTT
GTCAATAGCGCTTTCCTCAGAGCCAGCCTTAACCTGCTGTTGAGTCCATTAAAACGTTTGCTTAAAGTTTTTACCAATAATTAGATCATC
AGGGTTGTTTAGTGTGGGATCAAGCCATAACAAAACTGCCTAGCCTCTCAGGGGCCTAGAATTTACAGAACCTTCCTCCTCCCTGCAGCT
AGTCTCTCTTCTTTATTCTGGGGGCTGGGAAGGATCCCAAAACAGGGAACTTGGCCGAACCCTGGGCTTTGGATGCTAACCACTGAAGTA
CCAGCACCTGTAGGATGCTGTCTTTGAAGAAACTGAGGCGGACCTCCAAATGCAGCCCTAAGGCAGAGGTCAACGTGGAAGACCAGCCCT
TCTCCAAGCCCCACTGGTCTTTGCAAGCTGTACGTTGTAGGCAATCTGAGAACTGGAAAGGGGGACTACAACCAGAAAGTTGGTTACCCT

>23716_23716_3_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000344505_DUSP15_chr20_30457400_ENST00000278979_length(amino acids)=567AA_BP=276
MRQESMKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTP
VMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTE
DTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFG
DGKFSEVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAG
ISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALV
REATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQLRPGSSSCTLSASTERPDGSST

--------------------------------------------------------------
>23716_23716_4_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000348286_DUSP15_chr20_30457400_ENST00000278979_length(transcript)=2738nt_BP=1095nt
CGCAGCAGCTGCTCCCGGCTCCGCGGCCGCAGCCCGCGTGGACGCTCCGAGCGCCCCCCGACGGACGGGACCGGCTCCCTGGCGGTCGGG
CGAGCGGGCGGCAACGCTGCCCGGCCGGCAGCGCTGGGGTTAAGTGGCCCAAGTAAACCTAGCTCGGCGATCGGCGCCGGAGATTCGCGA
GCCCAGCGCCCTGCACGGCCGCCAGCCGGCCTCCCGCCAGCCAGCCCCGACCCGCGGCTCCGCCGCCCAGCCGCGCCCCAGCCAGCCCTG
CGGCAGGAAAGCATGAAGGGAGACACCAGGCATCTCAATGGAGAGGAGGACGCCGGCGGGAGGGAAGACTCGATCCTCGTCAACGGGGCC
TGCAGCGACCAGTCCTCCGACTCGCCCCCAATCCTGGAGGCTATCCGCACCCCGGAGATCAGAGGCCGAAGATCAAGCTCGCGACTCTCC
AAGAGGGAGGTGTCCAGTCTGCTAAGCTACACACAGGACTTGACAGGCGATGGCGACGGGGAAGATGGGGATGGCTCTGACACCCCAGTC
ATGCCAAAGCTCTTCCGGGAAACCAGGACTCGTTCAGAAAGCCCAGCTGTCCGAACTCGAAATAACAACAGTGTCTCCAGCCGGGAGAGG
CACAGGCCTTCCCCACGTTCCACCCGAGGCCGGCAGGGCCGCAACCATGTGGACGAGTCCCCCGTGGAGTTCCCGGCTACCAGGTCCCTG
AGACGGCGGGCAACAGCATCGGCAGGAACGCCATGGCCGTCCCCTCCCAGCTCTTACCTTACCATCGACCTCACAGACGACACAGAGGAC
ACACATGGGACGCCCCAGAGCAGCAGTACCCCCTACGCCCGCCTAGCCCAGGACAGCCAGCAGGGGGGCATGGAGTCCCCGCAGGTGGAG
GCAGACAGTGGAGATGGAGACAGTTCAGAGTATCAGGATGGGAAGGAGTTTGGAATAGGGGACCTCGTGTGGGGAAAGATCAAGGGCTTC
TCCTGGTGGCCCGCCATGGTGGTGTCTTGGAAGGCCACCTCCAAGCGACAGGCTATGTCTGGCATGCGGTGGGTCCAGTGGTTTGGCGAT
GGCAAGTTCTCCGAGGTACTTCCTGGACTCTACCTCGGAAACTTCATTGATGCCAAAGACCTGGATCAGCTGGGCCGAAATAAGATCACA
CACATCATCTCTATCCATGAGTCACCCCAGCCTCTGCTGCAGGATATCACCTACCTTCGCATCCCGGTCGCTGATACCCCTGAGGTACCC
ATCAAAAAGCACTTCAAAGAATGTATCAACTTCATCCACTGCTGCCGCCTTAATGGGGGGAACTGCCTTGTGCACTGCTTTGCAGGCATC
TCTCGCAGCACCACGATTGTGACAGCGTATGTGATGACTGTGACGGGGCTAGGCTGGCGGGACGTGCTTGAAGCCATCAAGGCCACCAGG
CCCATCGCCAACCCCAACCCAGGCTTTAGGCAGCAGCTTGAAGAGTTTGGCTGGGCCAGTTCCCAGAAGGGTGCCAGACATAGGACCTCA
AAAACCTCTGGTGCCCAATGCCCTCCGATGACTTCAGCAACCTGCCTGCTGGCTGCACGTGTGGCTCTTCTCTCCGCAGCGCTGGTGCGC
GAAGCCACCGGGCGCACAGCCCAGCGCTGTCGTCTGAGTCCGCGGGCGGCCGCCGAGCGCCTGCTGGGGCCGCCACCTCACGTTGCAGCA
GGATGGTCACCGGACCCAAAGTACCAGATCTGTCTGTGCTTCGGTGAGGAGGACCCGGGCCCCACACAGCACCCCAAGGAGCAGCTCATC
ATGGCGGACGTGCAGGTGCAGCTTCGGCCTGGGAGCTCGTCCTGCACTCTAAGTGCCTCAACCGAGCGCCCAGATGGGTCCTCAACCCCT
GGCAACCCCGATGGCATCACTCACCTTCAATGCAGCTGCCTCCATCCTAAGCGAGCCGCTTCCTCTTCTTGTACCCGCTGAAGGCAGCCC
CCAACAGGGGGGCTCCCTACTCCCACCCAACCCTGCCCACACTAAGCCCATAGACTTGGGGCCTCCCCCGGCACATCACCCAGGTCTGCC
GGACGGCAGAGGTGGATCGCGGCCTTCCACTCCTCTGTCACGGGGCCCCGGAACTCGAGAGTAGGCCACACCGCCCCCCAGCTGGGCATG
GGGCTTCGGCAGGAAACTGAACTTGATCTTGAGGCCCCAGAAAGGCAGCAACTGGAGCAGAAGCAAGACTTCATCTCTTGCTGACAGCCC
AATTTGTCAATAGCGCTTTCCTCAGAGCCAGCCTTAACCTGCTGTTGAGTCCATTAAAACGTTTGCTTAAAGTTTTTACCAATAATTAGA
TCATCAGGGTTGTTTAGTGTGGGATCAAGCCATAACAAAACTGCCTAGCCTCTCAGGGGCCTAGAATTTACAGAACCTTCCTCCTCCCTG
CAGCTAGTCTCTCTTCTTTATTCTGGGGGCTGGGAAGGATCCCAAAACAGGGAACTTGGCCGAACCCTGGGCTTTGGATGCTAACCACTG
AAGTACCAGCACCTGTAGGATGCTGTCTTTGAAGAAACTGAGGCGGACCTCCAAATGCAGCCCTAAGGCAGAGGTCAACGTGGAAGACCA
GCCCTTCTCCAAGCCCCACTGGTCTTTGCAAGCTGTACGTTGTAGGCAATCTGAGAACTGGAAAGGGGGACTACAACCAGAAAGTTGGTT

>23716_23716_4_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000348286_DUSP15_chr20_30457400_ENST00000278979_length(amino acids)=630AA_BP=339
MAVGRAGGNAARPAALGLSGPSKPSSAIGAGDSRAQRPARPPAGLPPASPDPRLRRPAAPQPALRQESMKGDTRHLNGEEDAGGREDSIL
VNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVS
SRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMES
PQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVLPGLYLGNFIDAKDLDQLGR
NKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAI
KATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPP
HVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQLRPGSSSCTLSASTERPDGSSTPGNPDGITHLQCSCLHPKRAASSSCTR

--------------------------------------------------------------
>23716_23716_5_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000353855_DUSP15_chr20_30457400_ENST00000278979_length(transcript)=2738nt_BP=1095nt
CGCAGCAGCTGCTCCCGGCTCCGCGGCCGCAGCCCGCGTGGACGCTCCGAGCGCCCCCCGACGGACGGGACCGGCTCCCTGGCGGTCGGG
CGAGCGGGCGGCAACGCTGCCCGGCCGGCAGCGCTGGGGTTAAGTGGCCCAAGTAAACCTAGCTCGGCGATCGGCGCCGGAGATTCGCGA
GCCCAGCGCCCTGCACGGCCGCCAGCCGGCCTCCCGCCAGCCAGCCCCGACCCGCGGCTCCGCCGCCCAGCCGCGCCCCAGCCAGCCCTG
CGGCAGGAAAGCATGAAGGGAGACACCAGGCATCTCAATGGAGAGGAGGACGCCGGCGGGAGGGAAGACTCGATCCTCGTCAACGGGGCC
TGCAGCGACCAGTCCTCCGACTCGCCCCCAATCCTGGAGGCTATCCGCACCCCGGAGATCAGAGGCCGAAGATCAAGCTCGCGACTCTCC
AAGAGGGAGGTGTCCAGTCTGCTAAGCTACACACAGGACTTGACAGGCGATGGCGACGGGGAAGATGGGGATGGCTCTGACACCCCAGTC
ATGCCAAAGCTCTTCCGGGAAACCAGGACTCGTTCAGAAAGCCCAGCTGTCCGAACTCGAAATAACAACAGTGTCTCCAGCCGGGAGAGG
CACAGGCCTTCCCCACGTTCCACCCGAGGCCGGCAGGGCCGCAACCATGTGGACGAGTCCCCCGTGGAGTTCCCGGCTACCAGGTCCCTG
AGACGGCGGGCAACAGCATCGGCAGGAACGCCATGGCCGTCCCCTCCCAGCTCTTACCTTACCATCGACCTCACAGACGACACAGAGGAC
ACACATGGGACGCCCCAGAGCAGCAGTACCCCCTACGCCCGCCTAGCCCAGGACAGCCAGCAGGGGGGCATGGAGTCCCCGCAGGTGGAG
GCAGACAGTGGAGATGGAGACAGTTCAGAGTATCAGGATGGGAAGGAGTTTGGAATAGGGGACCTCGTGTGGGGAAAGATCAAGGGCTTC
TCCTGGTGGCCCGCCATGGTGGTGTCTTGGAAGGCCACCTCCAAGCGACAGGCTATGTCTGGCATGCGGTGGGTCCAGTGGTTTGGCGAT
GGCAAGTTCTCCGAGGTACTTCCTGGACTCTACCTCGGAAACTTCATTGATGCCAAAGACCTGGATCAGCTGGGCCGAAATAAGATCACA
CACATCATCTCTATCCATGAGTCACCCCAGCCTCTGCTGCAGGATATCACCTACCTTCGCATCCCGGTCGCTGATACCCCTGAGGTACCC
ATCAAAAAGCACTTCAAAGAATGTATCAACTTCATCCACTGCTGCCGCCTTAATGGGGGGAACTGCCTTGTGCACTGCTTTGCAGGCATC
TCTCGCAGCACCACGATTGTGACAGCGTATGTGATGACTGTGACGGGGCTAGGCTGGCGGGACGTGCTTGAAGCCATCAAGGCCACCAGG
CCCATCGCCAACCCCAACCCAGGCTTTAGGCAGCAGCTTGAAGAGTTTGGCTGGGCCAGTTCCCAGAAGGGTGCCAGACATAGGACCTCA
AAAACCTCTGGTGCCCAATGCCCTCCGATGACTTCAGCAACCTGCCTGCTGGCTGCACGTGTGGCTCTTCTCTCCGCAGCGCTGGTGCGC
GAAGCCACCGGGCGCACAGCCCAGCGCTGTCGTCTGAGTCCGCGGGCGGCCGCCGAGCGCCTGCTGGGGCCGCCACCTCACGTTGCAGCA
GGATGGTCACCGGACCCAAAGTACCAGATCTGTCTGTGCTTCGGTGAGGAGGACCCGGGCCCCACACAGCACCCCAAGGAGCAGCTCATC
ATGGCGGACGTGCAGGTGCAGCTTCGGCCTGGGAGCTCGTCCTGCACTCTAAGTGCCTCAACCGAGCGCCCAGATGGGTCCTCAACCCCT
GGCAACCCCGATGGCATCACTCACCTTCAATGCAGCTGCCTCCATCCTAAGCGAGCCGCTTCCTCTTCTTGTACCCGCTGAAGGCAGCCC
CCAACAGGGGGGCTCCCTACTCCCACCCAACCCTGCCCACACTAAGCCCATAGACTTGGGGCCTCCCCCGGCACATCACCCAGGTCTGCC
GGACGGCAGAGGTGGATCGCGGCCTTCCACTCCTCTGTCACGGGGCCCCGGAACTCGAGAGTAGGCCACACCGCCCCCCAGCTGGGCATG
GGGCTTCGGCAGGAAACTGAACTTGATCTTGAGGCCCCAGAAAGGCAGCAACTGGAGCAGAAGCAAGACTTCATCTCTTGCTGACAGCCC
AATTTGTCAATAGCGCTTTCCTCAGAGCCAGCCTTAACCTGCTGTTGAGTCCATTAAAACGTTTGCTTAAAGTTTTTACCAATAATTAGA
TCATCAGGGTTGTTTAGTGTGGGATCAAGCCATAACAAAACTGCCTAGCCTCTCAGGGGCCTAGAATTTACAGAACCTTCCTCCTCCCTG
CAGCTAGTCTCTCTTCTTTATTCTGGGGGCTGGGAAGGATCCCAAAACAGGGAACTTGGCCGAACCCTGGGCTTTGGATGCTAACCACTG
AAGTACCAGCACCTGTAGGATGCTGTCTTTGAAGAAACTGAGGCGGACCTCCAAATGCAGCCCTAAGGCAGAGGTCAACGTGGAAGACCA
GCCCTTCTCCAAGCCCCACTGGTCTTTGCAAGCTGTACGTTGTAGGCAATCTGAGAACTGGAAAGGGGGACTACAACCAGAAAGTTGGTT

>23716_23716_5_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000353855_DUSP15_chr20_30457400_ENST00000278979_length(amino acids)=630AA_BP=339
MAVGRAGGNAARPAALGLSGPSKPSSAIGAGDSRAQRPARPPAGLPPASPDPRLRRPAAPQPALRQESMKGDTRHLNGEEDAGGREDSIL
VNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVS
SRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMES
PQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVLPGLYLGNFIDAKDLDQLGR
NKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAI
KATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPP
HVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQLRPGSSSCTLSASTERPDGSSTPGNPDGITHLQCSCLHPKRAASSSCTR

--------------------------------------------------------------
>23716_23716_6_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000375623_DUSP15_chr20_30457400_ENST00000278979_length(transcript)=2418nt_BP=775nt
ACGGCCGCCAGCCGGCCTCCCGCCAGCCAGCCCCGACCCGCGGCTCCGCCGCCCAGCCGCGCCCCAGCCAGCCCTGCGGCAGGAAAGCAT
GAAGGGAGACACCAGGCATCTCAATGGAGAGGAGGACGCCGGCGGGAGGGAAGACTCGATCCTCGTCAACGGGGCCTGCAGCGACCAGTC
CTCCGACTCGCCCCCAATCCTGGAGGCTATCCGCACCCCGGAGATCAGAGGCCGAAGATCAAGCTCGCGACTCTCCAAGAGGGAGGTGTC
CAGTCTGCTAAGCTACACACAGGACTTGACAGGCGATGGCGACGGGGAAGATGGGGATGGCTCTGACACCCCAGTCATGCCAAAGCTCTT
CCGGGAAACCAGGACTCGTTCAGAAAGCCCAGCTTCCCTGAGACGGCGGGCAACAGCATCGGCAGGAACGCCATGGCCGTCCCCTCCCAG
CTCTTACCTTACCATCGACCTCACAGACGACACAGAGGACACACATGGGACGCCCCAGAGCAGCAGTACCCCCTACGCCCGCCTAGCCCA
GGACAGCCAGCAGGGGGGCATGGAGTCCCCGCAGGTGGAGGCAGACAGTGGAGATGGAGACAGTTCAGAGTATCAGGATGGGAAGGAGTT
TGGAATAGGGGACCTCGTGTGGGGAAAGATCAAGGGCTTCTCCTGGTGGCCCGCCATGGTGGTGTCTTGGAAGGCCACCTCCAAGCGACA
GGCTATGTCTGGCATGCGGTGGGTCCAGTGGTTTGGCGATGGCAAGTTCTCCGAGGTACTTCCTGGACTCTACCTCGGAAACTTCATTGA
TGCCAAAGACCTGGATCAGCTGGGCCGAAATAAGATCACACACATCATCTCTATCCATGAGTCACCCCAGCCTCTGCTGCAGGATATCAC
CTACCTTCGCATCCCGGTCGCTGATACCCCTGAGGTACCCATCAAAAAGCACTTCAAAGAATGTATCAACTTCATCCACTGCTGCCGCCT
TAATGGGGGGAACTGCCTTGTGCACTGCTTTGCAGGCATCTCTCGCAGCACCACGATTGTGACAGCGTATGTGATGACTGTGACGGGGCT
AGGCTGGCGGGACGTGCTTGAAGCCATCAAGGCCACCAGGCCCATCGCCAACCCCAACCCAGGCTTTAGGCAGCAGCTTGAAGAGTTTGG
CTGGGCCAGTTCCCAGAAGGGTGCCAGACATAGGACCTCAAAAACCTCTGGTGCCCAATGCCCTCCGATGACTTCAGCAACCTGCCTGCT
GGCTGCACGTGTGGCTCTTCTCTCCGCAGCGCTGGTGCGCGAAGCCACCGGGCGCACAGCCCAGCGCTGTCGTCTGAGTCCGCGGGCGGC
CGCCGAGCGCCTGCTGGGGCCGCCACCTCACGTTGCAGCAGGATGGTCACCGGACCCAAAGTACCAGATCTGTCTGTGCTTCGGTGAGGA
GGACCCGGGCCCCACACAGCACCCCAAGGAGCAGCTCATCATGGCGGACGTGCAGGTGCAGCTTCGGCCTGGGAGCTCGTCCTGCACTCT
AAGTGCCTCAACCGAGCGCCCAGATGGGTCCTCAACCCCTGGCAACCCCGATGGCATCACTCACCTTCAATGCAGCTGCCTCCATCCTAA
GCGAGCCGCTTCCTCTTCTTGTACCCGCTGAAGGCAGCCCCCAACAGGGGGGCTCCCTACTCCCACCCAACCCTGCCCACACTAAGCCCA
TAGACTTGGGGCCTCCCCCGGCACATCACCCAGGTCTGCCGGACGGCAGAGGTGGATCGCGGCCTTCCACTCCTCTGTCACGGGGCCCCG
GAACTCGAGAGTAGGCCACACCGCCCCCCAGCTGGGCATGGGGCTTCGGCAGGAAACTGAACTTGATCTTGAGGCCCCAGAAAGGCAGCA
ACTGGAGCAGAAGCAAGACTTCATCTCTTGCTGACAGCCCAATTTGTCAATAGCGCTTTCCTCAGAGCCAGCCTTAACCTGCTGTTGAGT
CCATTAAAACGTTTGCTTAAAGTTTTTACCAATAATTAGATCATCAGGGTTGTTTAGTGTGGGATCAAGCCATAACAAAACTGCCTAGCC
TCTCAGGGGCCTAGAATTTACAGAACCTTCCTCCTCCCTGCAGCTAGTCTCTCTTCTTTATTCTGGGGGCTGGGAAGGATCCCAAAACAG
GGAACTTGGCCGAACCCTGGGCTTTGGATGCTAACCACTGAAGTACCAGCACCTGTAGGATGCTGTCTTTGAAGAAACTGAGGCGGACCT
CCAAATGCAGCCCTAAGGCAGAGGTCAACGTGGAAGACCAGCCCTTCTCCAAGCCCCACTGGTCTTTGCAAGCTGTACGTTGTAGGCAAT

>23716_23716_6_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000375623_DUSP15_chr20_30457400_ENST00000278979_length(amino acids)=525AA_BP=234
MRQESMKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTP
VMPKLFRETRTRSESPASLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEY
QDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQP
LLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQ
QLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQIC

--------------------------------------------------------------
>23716_23716_7_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000443239_DUSP15_chr20_30457400_ENST00000278979_length(transcript)=2440nt_BP=797nt
ATTCGCGAGCCCAGCGCCCTGCACGGCCGCCAGCCGGCCTCCCGCCAGCCAGCCCCGACCCGCGGCTCCGCCGCCCAGCCGCGCCCCAGC
CAGCCCTGCGGCAGGAAAGCATGAAGGGAGACACCAGGCATCTCAATGGAGAGGAGGACGCCGGCGGGAGGGAAGACTCGATCCTCGTCA
ACGGGGCCTGCAGCGACCAGTCCTCCGACTCGCCCCCAATCCTGGAGGCTATCCGCACCCCGGAGATCAGAGGCCGAAGATCAAGCTCGC
GACTCTCCAAGAGGGAGGTGTCCAGTCTGCTAAGCTACACACAGGACTTGACAGGCGATGGCGACGGGGAAGATGGGGATGGCTCTGACA
CCCCAGTCATGCCAAAGCTCTTCCGGGAAACCAGGACTCGTTCAGAAAGCCCAGCTTCCCTGAGACGGCGGGCAACAGCATCGGCAGGAA
CGCCATGGCCGTCCCCTCCCAGCTCTTACCTTACCATCGACCTCACAGACGACACAGAGGACACACATGGGACGCCCCAGAGCAGCAGTA
CCCCCTACGCCCGCCTAGCCCAGGACAGCCAGCAGGGGGGCATGGAGTCCCCGCAGGTGGAGGCAGACAGTGGAGATGGAGACAGTTCAG
AGTATCAGGATGGGAAGGAGTTTGGAATAGGGGACCTCGTGTGGGGAAAGATCAAGGGCTTCTCCTGGTGGCCCGCCATGGTGGTGTCTT
GGAAGGCCACCTCCAAGCGACAGGCTATGTCTGGCATGCGGTGGGTCCAGTGGTTTGGCGATGGCAAGTTCTCCGAGGTACTTCCTGGAC
TCTACCTCGGAAACTTCATTGATGCCAAAGACCTGGATCAGCTGGGCCGAAATAAGATCACACACATCATCTCTATCCATGAGTCACCCC
AGCCTCTGCTGCAGGATATCACCTACCTTCGCATCCCGGTCGCTGATACCCCTGAGGTACCCATCAAAAAGCACTTCAAAGAATGTATCA
ACTTCATCCACTGCTGCCGCCTTAATGGGGGGAACTGCCTTGTGCACTGCTTTGCAGGCATCTCTCGCAGCACCACGATTGTGACAGCGT
ATGTGATGACTGTGACGGGGCTAGGCTGGCGGGACGTGCTTGAAGCCATCAAGGCCACCAGGCCCATCGCCAACCCCAACCCAGGCTTTA
GGCAGCAGCTTGAAGAGTTTGGCTGGGCCAGTTCCCAGAAGGGTGCCAGACATAGGACCTCAAAAACCTCTGGTGCCCAATGCCCTCCGA
TGACTTCAGCAACCTGCCTGCTGGCTGCACGTGTGGCTCTTCTCTCCGCAGCGCTGGTGCGCGAAGCCACCGGGCGCACAGCCCAGCGCT
GTCGTCTGAGTCCGCGGGCGGCCGCCGAGCGCCTGCTGGGGCCGCCACCTCACGTTGCAGCAGGATGGTCACCGGACCCAAAGTACCAGA
TCTGTCTGTGCTTCGGTGAGGAGGACCCGGGCCCCACACAGCACCCCAAGGAGCAGCTCATCATGGCGGACGTGCAGGTGCAGCTTCGGC
CTGGGAGCTCGTCCTGCACTCTAAGTGCCTCAACCGAGCGCCCAGATGGGTCCTCAACCCCTGGCAACCCCGATGGCATCACTCACCTTC
AATGCAGCTGCCTCCATCCTAAGCGAGCCGCTTCCTCTTCTTGTACCCGCTGAAGGCAGCCCCCAACAGGGGGGCTCCCTACTCCCACCC
AACCCTGCCCACACTAAGCCCATAGACTTGGGGCCTCCCCCGGCACATCACCCAGGTCTGCCGGACGGCAGAGGTGGATCGCGGCCTTCC
ACTCCTCTGTCACGGGGCCCCGGAACTCGAGAGTAGGCCACACCGCCCCCCAGCTGGGCATGGGGCTTCGGCAGGAAACTGAACTTGATC
TTGAGGCCCCAGAAAGGCAGCAACTGGAGCAGAAGCAAGACTTCATCTCTTGCTGACAGCCCAATTTGTCAATAGCGCTTTCCTCAGAGC
CAGCCTTAACCTGCTGTTGAGTCCATTAAAACGTTTGCTTAAAGTTTTTACCAATAATTAGATCATCAGGGTTGTTTAGTGTGGGATCAA
GCCATAACAAAACTGCCTAGCCTCTCAGGGGCCTAGAATTTACAGAACCTTCCTCCTCCCTGCAGCTAGTCTCTCTTCTTTATTCTGGGG
GCTGGGAAGGATCCCAAAACAGGGAACTTGGCCGAACCCTGGGCTTTGGATGCTAACCACTGAAGTACCAGCACCTGTAGGATGCTGTCT
TTGAAGAAACTGAGGCGGACCTCCAAATGCAGCCCTAAGGCAGAGGTCAACGTGGAAGACCAGCCCTTCTCCAAGCCCCACTGGTCTTTG
CAAGCTGTACGTTGTAGGCAATCTGAGAACTGGAAAGGGGGACTACAACCAGAAAGTTGGTTACCCTGCCATGGGAATAAAGTAGCTGTT

>23716_23716_7_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000443239_DUSP15_chr20_30457400_ENST00000278979_length(amino acids)=525AA_BP=234
MRQESMKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTP
VMPKLFRETRTRSESPASLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEY
QDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQP
LLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQ
QLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQIC

--------------------------------------------------------------
>23716_23716_8_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000456297_DUSP15_chr20_30457400_ENST00000278979_length(transcript)=2292nt_BP=649nt
AGCCAGCCCCGACCCGCGGCTCCGCCGCCCAGCCGCGCCCCAGCCAGCCCTGCGGCAGGAAAGCATGAAGGGAGACACCAGGCATCTCAA
TGGAGAGGAGGACGCCGGCGGGAGGGAAGACTCGATCCTCGTCAACGGGGCCTGCAGCGACCAGTCCTCCGACTCGCCCCCAATCCTGGA
GGCTATCCGCACCCCGGAGATCAGAGGCCGAAGATCAAGCTCGCGACTCTCCAAGAGGGAGGTGTCCAGTCTGCTAAGCTACACACAGTC
CCTGAGACGGCGGGCAACAGCATCGGCAGGAACGCCATGGCCGTCCCCTCCCAGCTCTTACCTTACCATCGACCTCACAGACGACACAGA
GGACACACATGGGACGCCCCAGAGCAGCAGTACCCCCTACGCCCGCCTAGCCCAGGACAGCCAGCAGGGGGGCATGGAGTCCCCGCAGGT
GGAGGCAGACAGTGGAGATGGAGACAGTTCAGAGTATCAGGATGGGAAGGAGTTTGGAATAGGGGACCTCGTGTGGGGAAAGATCAAGGG
CTTCTCCTGGTGGCCCGCCATGGTGGTGTCTTGGAAGGCCACCTCCAAGCGACAGGCTATGTCTGGCATGCGGTGGGTCCAGTGGTTTGG
CGATGGCAAGTTCTCCGAGGTACTTCCTGGACTCTACCTCGGAAACTTCATTGATGCCAAAGACCTGGATCAGCTGGGCCGAAATAAGAT
CACACACATCATCTCTATCCATGAGTCACCCCAGCCTCTGCTGCAGGATATCACCTACCTTCGCATCCCGGTCGCTGATACCCCTGAGGT
ACCCATCAAAAAGCACTTCAAAGAATGTATCAACTTCATCCACTGCTGCCGCCTTAATGGGGGGAACTGCCTTGTGCACTGCTTTGCAGG
CATCTCTCGCAGCACCACGATTGTGACAGCGTATGTGATGACTGTGACGGGGCTAGGCTGGCGGGACGTGCTTGAAGCCATCAAGGCCAC
CAGGCCCATCGCCAACCCCAACCCAGGCTTTAGGCAGCAGCTTGAAGAGTTTGGCTGGGCCAGTTCCCAGAAGGGTGCCAGACATAGGAC
CTCAAAAACCTCTGGTGCCCAATGCCCTCCGATGACTTCAGCAACCTGCCTGCTGGCTGCACGTGTGGCTCTTCTCTCCGCAGCGCTGGT
GCGCGAAGCCACCGGGCGCACAGCCCAGCGCTGTCGTCTGAGTCCGCGGGCGGCCGCCGAGCGCCTGCTGGGGCCGCCACCTCACGTTGC
AGCAGGATGGTCACCGGACCCAAAGTACCAGATCTGTCTGTGCTTCGGTGAGGAGGACCCGGGCCCCACACAGCACCCCAAGGAGCAGCT
CATCATGGCGGACGTGCAGGTGCAGCTTCGGCCTGGGAGCTCGTCCTGCACTCTAAGTGCCTCAACCGAGCGCCCAGATGGGTCCTCAAC
CCCTGGCAACCCCGATGGCATCACTCACCTTCAATGCAGCTGCCTCCATCCTAAGCGAGCCGCTTCCTCTTCTTGTACCCGCTGAAGGCA
GCCCCCAACAGGGGGGCTCCCTACTCCCACCCAACCCTGCCCACACTAAGCCCATAGACTTGGGGCCTCCCCCGGCACATCACCCAGGTC
TGCCGGACGGCAGAGGTGGATCGCGGCCTTCCACTCCTCTGTCACGGGGCCCCGGAACTCGAGAGTAGGCCACACCGCCCCCCAGCTGGG
CATGGGGCTTCGGCAGGAAACTGAACTTGATCTTGAGGCCCCAGAAAGGCAGCAACTGGAGCAGAAGCAAGACTTCATCTCTTGCTGACA
GCCCAATTTGTCAATAGCGCTTTCCTCAGAGCCAGCCTTAACCTGCTGTTGAGTCCATTAAAACGTTTGCTTAAAGTTTTTACCAATAAT
TAGATCATCAGGGTTGTTTAGTGTGGGATCAAGCCATAACAAAACTGCCTAGCCTCTCAGGGGCCTAGAATTTACAGAACCTTCCTCCTC
CCTGCAGCTAGTCTCTCTTCTTTATTCTGGGGGCTGGGAAGGATCCCAAAACAGGGAACTTGGCCGAACCCTGGGCTTTGGATGCTAACC
ACTGAAGTACCAGCACCTGTAGGATGCTGTCTTTGAAGAAACTGAGGCGGACCTCCAAATGCAGCCCTAAGGCAGAGGTCAACGTGGAAG
ACCAGCCCTTCTCCAAGCCCCACTGGTCTTTGCAAGCTGTACGTTGTAGGCAATCTGAGAACTGGAAAGGGGGACTACAACCAGAAAGTT

>23716_23716_8_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000456297_DUSP15_chr20_30457400_ENST00000278979_length(amino acids)=491AA_BP=200
MRQESMKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQSLRRRATASAGTPWPSP
PSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSK
RQAMSGMRWVQWFGDGKFSEVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCC
RLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQCPPMTSATC
LLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQLRPGSSSC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DNMT3B-DUSP15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+7221_298283.0846.0DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+7231_298271.0854.0DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+7211_298271.0793.0DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+7201_298271.0771.0DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+7221_298271.0834.0DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+6191_298229.0729.0DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+5181_298195.0695.0DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+722435_527283.0846.0the PRC2/EED-EZH2 complex
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+723435_527271.0854.0the PRC2/EED-EZH2 complex
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+721435_527271.0793.0the PRC2/EED-EZH2 complex
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+720435_527271.0771.0the PRC2/EED-EZH2 complex
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+722435_527271.0834.0the PRC2/EED-EZH2 complex
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+619435_527229.0729.0the PRC2/EED-EZH2 complex
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+518435_527195.0695.0the PRC2/EED-EZH2 complex


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNMT3B-DUSP15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneDNMT3BQ9UBC3DB01262DecitabineInhibitorSmall moleculeApproved|Investigational

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Related Diseases for DNMT3B-DUSP15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNMT3BC4551557IMMUNODEFICIENCY-CENTROMERIC INSTABILITY-FACIAL ANOMALIES SYNDROME 111CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneDNMT3BC0006142Malignant neoplasm of breast2CTD_human
HgeneDNMT3BC0678222Breast Carcinoma2CTD_human
HgeneDNMT3BC1257931Mammary Neoplasms, Human2CTD_human
HgeneDNMT3BC1458155Mammary Neoplasms2CTD_human
HgeneDNMT3BC4704874Mammary Carcinoma, Human2CTD_human
HgeneDNMT3BC0003257Antibody Deficiency Syndrome1CTD_human
HgeneDNMT3BC0007097Carcinoma1CTD_human
HgeneDNMT3BC0021051Immunologic Deficiency Syndromes1CTD_human
HgeneDNMT3BC0024623Malignant neoplasm of stomach1CTD_human
HgeneDNMT3BC0033578Prostatic Neoplasms1CTD_human
HgeneDNMT3BC0036341Schizophrenia1PSYGENET
HgeneDNMT3BC0038356Stomach Neoplasms1CTD_human
HgeneDNMT3BC0205696Anaplastic carcinoma1CTD_human
HgeneDNMT3BC0205697Carcinoma, Spindle-Cell1CTD_human
HgeneDNMT3BC0205698Undifferentiated carcinoma1CTD_human
HgeneDNMT3BC0205699Carcinomatosis1CTD_human
HgeneDNMT3BC0376358Malignant neoplasm of prostate1CTD_human
HgeneDNMT3BC0376634Craniofacial Abnormalities1CTD_human
HgeneDNMT3BC0525045Mood Disorders1PSYGENET
HgeneDNMT3BC0796113Nephroblastomatosis, fetal ascites, macrosomia and Wilms tumor1GENOMICS_ENGLAND
HgeneDNMT3BC1510586Autism Spectrum Disorders1CTD_human
HgeneDNMT3BC1656427Early onset schizophrenia1PSYGENET
HgeneDNMT3BC1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneDNMT3BC1834671FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY 1B1UNIPROT
HgeneDNMT3BC2931456Prostate cancer, familial1CTD_human
HgeneDNMT3BC4722327PROSTATE CANCER, HEREDITARY, 11CTD_human