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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ALDH2-RPL31 (FusionGDB2 ID:HG217TG6160)

Fusion Gene Summary for ALDH2-RPL31

check button Fusion gene summary
Fusion gene informationFusion gene name: ALDH2-RPL31
Fusion gene ID: hg217tg6160
HgeneTgene
Gene symbol

ALDH2

RPL31

Gene ID

217

6160

Gene namealdehyde dehydrogenase 2 family memberribosomal protein L31
SynonymsALDH-E2|ALDHI|ALDML31
Cytomap('ALDH2')('RPL31')

12q24.12

2q11.2

Type of geneprotein-codingprotein-coding
Descriptionaldehyde dehydrogenase, mitochondrialALDH class 2acetaldehyde dehydrogenase 2aldehyde dehydrogenase 2 family (mitochondrial)epididymis secretory sperm binding proteinliver mitochondrial ALDHnucleus-encoded mitochondrial aldehyde dehydrogenase 260S ribosomal protein L31large ribosomal subunit protein eL31
Modification date2020031320200313
UniProtAcc

P05091

.
Ensembl transtripts involved in fusion geneENST00000261733, ENST00000416293, 
Fusion gene scores* DoF score26 X 20 X 11=572016 X 11 X 5=880
# samples 2117
** MAII scorelog2(21/5720*10)=-4.76755391399963
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(17/880*10)=-2.37196877738696
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALDH2 [Title/Abstract] AND RPL31 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALDH2(112221074)-RPL31(101619194), # samples:1
Anticipated loss of major functional domain due to fusion event.ALDH2-RPL31 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ALDH2-RPL31 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ALDH2-RPL31 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ALDH2-RPL31 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRPL31

GO:0002181

cytoplasmic translation

25957688


check buttonFusion gene breakpoints across ALDH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RPL31 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-3930-01AALDH2chr12

112221074

+RPL31chr2

101619194

+


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Fusion Gene ORF analysis for ALDH2-RPL31

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000261733ENST00000409711ALDH2chr12

112221074

+RPL31chr2

101619194

+
Frame-shiftENST00000261733ENST00000409733ALDH2chr12

112221074

+RPL31chr2

101619194

+
In-frameENST00000261733ENST00000264258ALDH2chr12

112221074

+RPL31chr2

101619194

+
In-frameENST00000261733ENST00000409000ALDH2chr12

112221074

+RPL31chr2

101619194

+
In-frameENST00000261733ENST00000409028ALDH2chr12

112221074

+RPL31chr2

101619194

+
In-frameENST00000261733ENST00000409038ALDH2chr12

112221074

+RPL31chr2

101619194

+
In-frameENST00000261733ENST00000409320ALDH2chr12

112221074

+RPL31chr2

101619194

+
In-frameENST00000261733ENST00000409650ALDH2chr12

112221074

+RPL31chr2

101619194

+
intron-3CDSENST00000416293ENST00000264258ALDH2chr12

112221074

+RPL31chr2

101619194

+
intron-3CDSENST00000416293ENST00000409000ALDH2chr12

112221074

+RPL31chr2

101619194

+
intron-3CDSENST00000416293ENST00000409028ALDH2chr12

112221074

+RPL31chr2

101619194

+
intron-3CDSENST00000416293ENST00000409038ALDH2chr12

112221074

+RPL31chr2

101619194

+
intron-3CDSENST00000416293ENST00000409320ALDH2chr12

112221074

+RPL31chr2

101619194

+
intron-3CDSENST00000416293ENST00000409650ALDH2chr12

112221074

+RPL31chr2

101619194

+
intron-3CDSENST00000416293ENST00000409711ALDH2chr12

112221074

+RPL31chr2

101619194

+
intron-3CDSENST00000416293ENST00000409733ALDH2chr12

112221074

+RPL31chr2

101619194

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000261733ALDH2chr12112221074+ENST00000264258RPL31chr2101619194+154130861654197
ENST00000261733ALDH2chr12112221074+ENST00000409000RPL31chr2101619194+83130861516151
ENST00000261733ALDH2chr12112221074+ENST00000409028RPL31chr2101619194+135430861663200
ENST00000261733ALDH2chr12112221074+ENST00000409320RPL31chr2101619194+97030861642193
ENST00000261733ALDH2chr12112221074+ENST00000409650RPL31chr2101619194+102430861639192
ENST00000261733ALDH2chr12112221074+ENST00000409038RPL31chr2101619194+107130861669202

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261733ENST00000264258ALDH2chr12112221074+RPL31chr2101619194+0.0011143520.9988857
ENST00000261733ENST00000409000ALDH2chr12112221074+RPL31chr2101619194+0.0220884330.9779116
ENST00000261733ENST00000409028ALDH2chr12112221074+RPL31chr2101619194+0.0021482060.99785185
ENST00000261733ENST00000409320ALDH2chr12112221074+RPL31chr2101619194+0.0030220470.9969779
ENST00000261733ENST00000409650ALDH2chr12112221074+RPL31chr2101619194+0.0027515770.99724835
ENST00000261733ENST00000409038ALDH2chr12112221074+RPL31chr2101619194+0.0025787580.99742126

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Fusion Genomic Features for ALDH2-RPL31


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ALDH2-RPL31


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:112221074/chr2:101619194)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALDH2

P05091

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALDH2chr12:112221074chr2:101619194ENST00000261733+113262_2670518.0Nucleotide bindingNAD
HgeneALDH2chr12:112221074chr2:101619194ENST00000416293+112262_2670471.0Nucleotide bindingNAD


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Fusion Gene Sequence for ALDH2-RPL31


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3884_3884_1_ALDH2-RPL31_ALDH2_chr12_112221074_ENST00000261733_RPL31_chr2_101619194_ENST00000264258_length(transcript)=1541nt_BP=308nt
TCAGTGGCCCTGAGACCCTAGCTCTGCTCTCGGTCCGCTCGCTGTCCGCTAGCCCGCTGCGATGTTGCGCGCTGCCGCCCGCTTCGGGCC
CCGCCTGGGCCGCCGCCTCTTGTCAGCCGCCGCCACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTT
CATAAACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACTGGAGAGGTCATCTGTCAGGTAGCTGA
AGGGGACAAGGATCGAGCGGGACCGGACCTACCTGGCGAAAAGGGCCGTTCTGCCATCAACGAAGTGGTAACCCGAGAATACACCATCAA
CATTCACAAGCGCATCCATGGAGTGGGCTTCAAGAAGCGTGCACCTCGGGCACTCAAAGAGATTCGGAAATTTGCCATGAAGGAGATGGG
AACTCCAGATGTGCGCATTGACACCAGGCTCAACAAAGCTGTCTGGGCCAAAGGAATAAGGAATGTGCCATACCGAATCCGTGTGCGGCT
GTCCAGAAAACGTAATGAGGATGAAGATTCACCAAATAAGCTATATACTTTGGTTACCTATGTACCTGTTACCACTTTCAAAAATCTACA
GACAGTCAATGTGGATGAGAACTAATCGCTGATCGTCAGATCAAATAAAGTTATAAAATTGCCTTCATGTTTTTGTTCTTTTTAGTTGCA
ACATAATGTACTTGTATACCCTATCCTAATTATGGGATCATTTGAAGAGCTTTTCCCAAATTGATGGCCTGTGCTGCCTTCTCCCCATCC
CCTGGGGTTTTAAAGTGATTTCAAACTGCAACCTAGTTTTAGAACCACTGTTCTGGGTAGTTGGGATACTGAAGGCATATTGTTAATTAT
TCTACTTGTATGTTTTGCTAATTCTAAGATAAGCATTTTTCCAGAAACCAGGATGTAGAATCCAGTTGCCATTGACATCTTAACATTTTA
GGAAACAACTTTAAAATGATATACTATCTATCTATCTATCTGTAGCATCTTAAAGGTAATGAAATTAATGTGGCAGTAGGTCTTTTAAGC
TTCTGCCTACATCCATATTGAGTATAGTTGTTGTCTTCTAAAATAATTAATTGATTTTTGGTGAGATAACCAGATTCATATTTTAAGCCT
TTTGTAATGGCCCCGTGGTACCTGGAGTCAAGGTTCAGAAGTAAAAAGTTCCTTAAGGTATCAATAACAAAAATTTGTATTAATAGTTCA
GTCCTAAAGCAGTGTTGCTGAGATTATGTTTCACCAGCATTTACAAGCTGTATGTTAAATGCTGCCATAAAGAGGTCTCTGAAGCCGTAG
GGCACACCCAAGGCAGGGCTGAGAAGTACCTAGTAGTGTTGCACCACCCAAAAACCATGGATGGGCAGCAGCAACATCTCCAGCTTACCC
ATTCACTGCCACAGTCTACAGCTTAAGACACTTAACTACAAGGTAAAAGAAAAGGACCAAGTAAATACAAAAAGTTTCTTATTAAAAAAC

>3884_3884_1_ALDH2-RPL31_ALDH2_chr12_112221074_ENST00000261733_RPL31_chr2_101619194_ENST00000264258_length(amino acids)=197AA_BP=83
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKDRAGPDLPGEKGRSAIN
EVVTREYTINIHKRIHGVGFKKRAPRALKEIRKFAMKEMGTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDEDSPNKLYTLVTY

--------------------------------------------------------------
>3884_3884_2_ALDH2-RPL31_ALDH2_chr12_112221074_ENST00000261733_RPL31_chr2_101619194_ENST00000409000_length(transcript)=831nt_BP=308nt
TCAGTGGCCCTGAGACCCTAGCTCTGCTCTCGGTCCGCTCGCTGTCCGCTAGCCCGCTGCGATGTTGCGCGCTGCCGCCCGCTTCGGGCC
CCGCCTGGGCCGCCGCCTCTTGTCAGCCGCCGCCACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTT
CATAAACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACTGGAGAGGTCATCTGTCAGGTAGCTGA
AGGGGACAAGGATCGAGCGGGACCGGACCTACCTGGCGAAAAGGGCCGTTCTGCCATCAACGAAGTGGTAACCCGAGAATACACCATCAA
CATTCACAAGCGCATCCATGGAGTGGGCTTCAAGAAGCGTGCACCTCGGGCACTCAAAGAGATTCGGAAATTTGCCATGAAGGAGATGGG
AACTCCAGATGTGCGCATTGACACCAGGCTCAACAAAGCTGTCTGGGCCAAAGGAATAAGGTGCTAAAGTTATCTGTATTCGAAGGTGAA
CTTTTGCAATGACACCAGCTTCACTTAACCCTGCAAGAGCCCATATCAGTTCAGTAATTTGGTTAATGCATGTGGAAGTATAAAAAAAAA
AAATACTGTGACCGTGACTTAGGGTGTGTAGTATCTGCAGGGAAGCCCCTTAATTTAGTGGCTTATGAACTGAGACCCAAGGGAAGGAGC
CAGCAGTGTAGGGTGGGAAAGAGCATTGCAGAGAGAGGAAGCTTGGCAGGATCTGGGAGCGGGGTGGTGAACGCAGGTAAAGTGGAATAA

>3884_3884_2_ALDH2-RPL31_ALDH2_chr12_112221074_ENST00000261733_RPL31_chr2_101619194_ENST00000409000_length(amino acids)=151AA_BP=83
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKDRAGPDLPGEKGRSAIN

--------------------------------------------------------------
>3884_3884_3_ALDH2-RPL31_ALDH2_chr12_112221074_ENST00000261733_RPL31_chr2_101619194_ENST00000409028_length(transcript)=1354nt_BP=308nt
TCAGTGGCCCTGAGACCCTAGCTCTGCTCTCGGTCCGCTCGCTGTCCGCTAGCCCGCTGCGATGTTGCGCGCTGCCGCCCGCTTCGGGCC
CCGCCTGGGCCGCCGCCTCTTGTCAGCCGCCGCCACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTT
CATAAACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACTGGAGAGGTCATCTGTCAGGTAGCTGA
AGGGGACAAGGATCGAGCGGGACCGGACCTACCTGGCGAAAAGGGCCGTTCTGCCATCAACGAAGTGGTAACCCGAGAATACACCATCAA
CATTCACAAGCGCATCCATGGAGTGGGCTTCAAGAAGCGTGCACCTCGGGCACTCAAAGAGATTCGGAAATTTGCCATGAAGGAGATGGG
AACTCCAGATGTGCGCATTGACACCAGGCTCAACAAAGCTGTCTGGGCCAAAGGAATAAGGAATGTGCCATACCGAATCCGTGTGCGGCT
GTCCAGAAAACGTAATGAGGATGAAGATTCACCAAATAAGCTATATACTTTGGTTACCTATGTACCTGTTACCACTTTCAAAATTTCTGT
GCTAAACAGTGTTACAGTCGCCAAGAGCCCATAAAGGGAGCCCTCCTGGAAGTGGATGAGGCCTTGGGTCTCGGCTCTTCATTGCTTCCT
GAGCTGCAGCAGATGCCTTTACAACCAAGCTCACCGAGGACGTCTGTCTCCCATATTACCCTGGCAGAGGGCCAGGCCTGTTCTACACGG
CCGGGGTTTCAACAAGGTACTGATGTCTTCTGCCCTTGCCTCTTCGACAGGCAAGTAATAAGACTTAAGTGAAGAGAATTCTTTAGGCAC
ACAAATTCACATTTGATGTAATCTCATTATACTTCCTGATCTGTGATTGAAAACTTTCATTTCGTAACTAGTATGTCTGTCCCACCTTTA
AAAAGTTTTTCATTATGAAAGTAAGTATTTGTTAGAATTAAGTCTATTTAAATGAAAAAAACTTAGATATGAGTCTGCATGGCCTCAGGA
AAATGATGTTTTAAAATAGAGATTTTAGGTTGTCTGCACTCTAGCTTTTTTGTCGTTTTCTTAAGGCTTTTTTAACTGCATCAAAAATTC
AGATACGAAACATACACTAAAAAATAATACATCATATCTTAATTTCCACTGAACTTGATTTAAATTCAGAGTTACACAGTATGAATATCA
CAATCAGATATGTTCAAAAAGGTCTGAACAATTGATTTTCTGAAACCATGAAGGACTACAAATGCTTCTAATAAATCAATGTAATTAAAA

>3884_3884_3_ALDH2-RPL31_ALDH2_chr12_112221074_ENST00000261733_RPL31_chr2_101619194_ENST00000409028_length(amino acids)=200AA_BP=83
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKDRAGPDLPGEKGRSAIN
EVVTREYTINIHKRIHGVGFKKRAPRALKEIRKFAMKEMGTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDEDSPNKLYTLVTY

--------------------------------------------------------------
>3884_3884_4_ALDH2-RPL31_ALDH2_chr12_112221074_ENST00000261733_RPL31_chr2_101619194_ENST00000409038_length(transcript)=1071nt_BP=308nt
TCAGTGGCCCTGAGACCCTAGCTCTGCTCTCGGTCCGCTCGCTGTCCGCTAGCCCGCTGCGATGTTGCGCGCTGCCGCCCGCTTCGGGCC
CCGCCTGGGCCGCCGCCTCTTGTCAGCCGCCGCCACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTT
CATAAACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACTGGAGAGGTCATCTGTCAGGTAGCTGA
AGGGGACAAGGATCGAGCGGGACCGGACCTACCTGGCGAAAAGGGCCGTTCTGCCATCAACGAAGTGGTAACCCGAGAATACACCATCAA
CATTCACAAGCGCATCCATGGAGTGGGCTTCAAGAAGCGTGCACCTCGGGCACTCAAAGAGATTCGGAAATTTGCCATGAAGGAGATGGG
AACTCCAGATGTGCGCATTGACACCAGGCTCAACAAAGCTGTCTGGGCCAAAGGAATAAGGAATGTGCCATACCGAATCCGTGTGCGGCT
GTCCAGAAAACGTAATGAGGATGAAGATTCACCAAATAAGCTATATACTTTGGTTACCTATGTACCTGTTACCACTTTCAAAAGTCTTCA
AAACGATGATCTCTTCAAAACAGATTGTCACCATCAGTGAGAAACCGAACAAGAAGAGGAAAGCAAATGGCATTTTCTTCTCTACTTGGT
GAAAAGTCATTATAGAGGATTCGAACGGTTCCAATGCTCGCAATTCTACTTCAAGCATGTGCTCATTCTACATATCAACCCCTTTTTCAC
TGACAAATGTAATGTTGACAATCTAGGCTAATGGGACTAGATTTTGAATCCAATCAACACTTTTTCATATAAAGTTTTCAGAATAACAAA
GCTTTCCCTCATTCATACAGATATTGCTGTACTAATCTATAATTATGTTTTAGAATTCAAATTATAACACTGACTAAACATCACTAATGA

>3884_3884_4_ALDH2-RPL31_ALDH2_chr12_112221074_ENST00000261733_RPL31_chr2_101619194_ENST00000409038_length(amino acids)=202AA_BP=83
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKDRAGPDLPGEKGRSAIN
EVVTREYTINIHKRIHGVGFKKRAPRALKEIRKFAMKEMGTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDEDSPNKLYTLVTY

--------------------------------------------------------------
>3884_3884_5_ALDH2-RPL31_ALDH2_chr12_112221074_ENST00000261733_RPL31_chr2_101619194_ENST00000409320_length(transcript)=970nt_BP=308nt
TCAGTGGCCCTGAGACCCTAGCTCTGCTCTCGGTCCGCTCGCTGTCCGCTAGCCCGCTGCGATGTTGCGCGCTGCCGCCCGCTTCGGGCC
CCGCCTGGGCCGCCGCCTCTTGTCAGCCGCCGCCACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTT
CATAAACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACTGGAGAGGTCATCTGTCAGGTAGCTGA
AGGGGACAAGGATCGAGCGGGACCGGACCTACCTGGCGAAAAGGGCCGTTCTGCCATCAACGAAGTGGTAACCCGAGAATACACCATCAA
CATTCACAAGCGCATCCATGGAGTGGGCTTCAAGAAGCGTGCACCTCGGGCACTCAAAGAGATTCGGAAATTTGCCATGAAGGAGATGGG
AACTCCAGATGTGCGCATTGACACCAGGCTCAACAAAGCTGTCTGGGCCAAAGGAATAAGGAATGTGCCATACCGAATCCGTGTGCGGCT
GTCCAGAAAACGTAATGAGGATGAAGATTCACCAAATAAGCTATATACTTTGGTTACCTATGTACCTGTTACCACTTTCAAAAGTAAGTT
CTCCATCCCATAAAGCCATTTAAATTCATTAGAAAAATGTCCTTACCTCTTAAAATGTGAATTCATCTGTTAAGCTAGGGGTGACACACG
TCATTGTACCCTTTTTAAATTGTTGGTGTGGGAAGATGCTAAAGAATGCAAAACTGATCCATATCTGGGATGTAAAAAGGTTGTGGAAAA
TAGAATGCCCAGACCCGTCTACAAAAGGTTTTTAGAGTTGAAATATGAAATGTGATGTGGGTATGGAAATTGACTGTTACTTCCTTTACA

>3884_3884_5_ALDH2-RPL31_ALDH2_chr12_112221074_ENST00000261733_RPL31_chr2_101619194_ENST00000409320_length(amino acids)=193AA_BP=83
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKDRAGPDLPGEKGRSAIN
EVVTREYTINIHKRIHGVGFKKRAPRALKEIRKFAMKEMGTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDEDSPNKLYTLVTY

--------------------------------------------------------------
>3884_3884_6_ALDH2-RPL31_ALDH2_chr12_112221074_ENST00000261733_RPL31_chr2_101619194_ENST00000409650_length(transcript)=1024nt_BP=308nt
TCAGTGGCCCTGAGACCCTAGCTCTGCTCTCGGTCCGCTCGCTGTCCGCTAGCCCGCTGCGATGTTGCGCGCTGCCGCCCGCTTCGGGCC
CCGCCTGGGCCGCCGCCTCTTGTCAGCCGCCGCCACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTT
CATAAACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACTGGAGAGGTCATCTGTCAGGTAGCTGA
AGGGGACAAGGATCGAGCGGGACCGGACCTACCTGGCGAAAAGGGCCGTTCTGCCATCAACGAAGTGGTAACCCGAGAATACACCATCAA
CATTCACAAGCGCATCCATGGAGTGGGCTTCAAGAAGCGTGCACCTCGGGCACTCAAAGAGATTCGGAAATTTGCCATGAAGGAGATGGG
AACTCCAGATGTGCGCATTGACACCAGGCTCAACAAAGCTGTCTGGGCCAAAGGAATAAGGAATGTGCCATACCGAATCCGTGTGCGGCT
GTCCAGAAAACGTAATGAGGATGAAGATTCACCAAATAAGCTATATACTTTGGTTACCTATGTACCTGTTACCACTTTCAAAAATTGTCA
CCATCAGTGAGAAACCGAACAAGAAGAGGAAAGCAAATGGCATTTTCTTCTCTACTTGGTGAAAAGTCATTATAGAGGATTCGAACGGTT
CCAATGCTCGCAATTCTACTTCAAGCATGTGCTCATTCTACATATCAACCCCTTTTTCACTGACAAATGTAATGTTGACAATCTAGGCTA
ATGGGACTAGATTTTGAATCCAATCAACACTTTTTCATATAAAGTTTTCAGAATAACAAAGCTTTCCCTCATTCATACAGATATTGCTGT
ACTAATCTATAATTATGTTTTAGAATTCAAATTATAACACTGACTAAACATCACTAATGAAACATTTGTGACCTCCTTTTTTCCGAAGTT

>3884_3884_6_ALDH2-RPL31_ALDH2_chr12_112221074_ENST00000261733_RPL31_chr2_101619194_ENST00000409650_length(amino acids)=192AA_BP=83
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKDRAGPDLPGEKGRSAIN
EVVTREYTINIHKRIHGVGFKKRAPRALKEIRKFAMKEMGTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDEDSPNKLYTLVTY

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Fusion Gene PPI Analysis for ALDH2-RPL31


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ALDH2-RPL31


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneALDH2P05091DB00536GuanidineInhibitorSmall moleculeApproved
HgeneALDH2P05091DB00536GuanidineInhibitorSmall moleculeApproved
HgeneALDH2P05091DB00822DisulfiramInhibitorSmall moleculeApproved
HgeneALDH2P05091DB00822DisulfiramInhibitorSmall moleculeApproved
HgeneALDH2P05091DB00157NADHSmall moleculeApproved|Nutraceutical
HgeneALDH2P05091DB00157NADHSmall moleculeApproved|Nutraceutical

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Related Diseases for ALDH2-RPL31


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALDH2C0001973Alcoholic Intoxication, Chronic7CTD_human;PSYGENET
HgeneALDH2C0085762Alcohol abuse7CTD_human;PSYGENET
HgeneALDH2C0001969Alcoholic Intoxication5PSYGENET
HgeneALDH2C0393756Hangover from alcohol4PSYGENET
HgeneALDH2C0236664Alcohol-Related Disorders3PSYGENET
HgeneALDH2C0001956Alcohol Use Disorder2CTD_human
HgeneALDH2C0004096Asthma2CTD_human
HgeneALDH2C0005586Bipolar Disorder2PSYGENET
HgeneALDH2C0279626Squamous cell carcinoma of esophagus2CTD_human
HgeneALDH2C0009402Colorectal Carcinoma1CTD_human
HgeneALDH2C0009404Colorectal Neoplasms1CTD_human
HgeneALDH2C0014859Esophageal Neoplasms1CTD_human
HgeneALDH2C0016382Flushing1CTD_human
HgeneALDH2C0016689Freckles1CTD_human
HgeneALDH2C0021364Male infertility1CTD_human
HgeneALDH2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneALDH2C0025209Melanosis1CTD_human
HgeneALDH2C0025218Chloasma1CTD_human
HgeneALDH2C0028796Dermatitis, Occupational1CTD_human
HgeneALDH2C0032927Precancerous Conditions1CTD_human
HgeneALDH2C0042373Vascular Diseases1CTD_human
HgeneALDH2C0086457Industrial Dermatosis1CTD_human
HgeneALDH2C0236970Alcohol-Induced Disorders1CTD_human
HgeneALDH2C0242973Ventricular Dysfunction1CTD_human
HgeneALDH2C0282313Condition, Preneoplastic1CTD_human
HgeneALDH2C0342257Complications of Diabetes Mellitus1CTD_human
HgeneALDH2C0349464Wernicke-Korsakoff Syndrome1PSYGENET
HgeneALDH2C0400966Non-alcoholic Fatty Liver Disease1CTD_human
HgeneALDH2C0520459Necrotizing Enterocolitis1CTD_human
HgeneALDH2C0546837Malignant neoplasm of esophagus1CTD_human
HgeneALDH2C0848676Subfertility, Male1CTD_human
HgeneALDH2C0917731Male sterility1CTD_human
HgeneALDH2C2674838ALCOHOL SENSITIVITY, ACUTE1CTD_human
HgeneALDH2C3241937Nonalcoholic Steatohepatitis1CTD_human
TgeneC1260899Anemia, Diamond-Blackfan2GENOMICS_ENGLAND
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human