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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:MAPRE1-USP28 (FusionGDB2 ID:HG22919TG57646) |
Fusion Gene Summary for MAPRE1-USP28 |
Fusion gene summary |
Fusion gene information | Fusion gene name: MAPRE1-USP28 | Fusion gene ID: hg22919tg57646 | Hgene | Tgene | Gene symbol | MAPRE1 | USP28 | Gene ID | 22919 | 57646 |
Gene name | microtubule associated protein RP/EB family member 1 | ubiquitin specific peptidase 28 | |
Synonyms | EB1 | - | |
Cytomap | ('MAPRE1')('USP28') 20q11.21 | 11q23.2 | |
Type of gene | protein-coding | protein-coding | |
Description | microtubule-associated protein RP/EB family member 1APC-binding protein EB1adenomatous polyposis coli-binding protein EB1end-binding protein 1 | ubiquitin carboxyl-terminal hydrolase 28deubiquitinating enzyme 28ubiquitin carboxyl-terminal hydrolase 28 variant 1ubiquitin thioesterase 28ubiquitin thiolesterase 28ubiquitin-specific-processing protease 28 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q15691 | . | |
Ensembl transtripts involved in fusion gene | ENST00000375571, | ||
Fusion gene scores | * DoF score | 10 X 7 X 7=490 | 8 X 8 X 6=384 |
# samples | 12 | 9 | |
** MAII score | log2(12/490*10)=-2.02974734339405 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/384*10)=-2.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MAPRE1 [Title/Abstract] AND USP28 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | MAPRE1(31427662)-USP28(113705057), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | MAPRE1-USP28 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAPRE1-USP28 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAPRE1-USP28 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MAPRE1-USP28 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MAPRE1 | GO:0031115 | negative regulation of microtubule polymerization | 11943150 |
Hgene | MAPRE1 | GO:0035372 | protein localization to microtubule | 19632184|21820309 |
Tgene | USP28 | GO:0006974 | cellular response to DNA damage stimulus | 17873522 |
Tgene | USP28 | GO:0010212 | response to ionizing radiation | 16901786 |
Tgene | USP28 | GO:0016579 | protein deubiquitination | 16901786|17558397|18662541 |
Tgene | USP28 | GO:0034644 | cellular response to UV | 17873522 |
Tgene | USP28 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 16901786 |
Fusion gene breakpoints across MAPRE1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across USP28 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | PRAD | TCGA-EJ-7785-01A | MAPRE1 | chr20 | 31427662 | - | USP28 | chr11 | 113705057 | - |
ChimerDB4 | PRAD | TCGA-EJ-7785-01A | MAPRE1 | chr20 | 31427662 | + | USP28 | chr11 | 113705057 | - |
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Fusion Gene ORF analysis for MAPRE1-USP28 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000375571 | ENST00000542033 | MAPRE1 | chr20 | 31427662 | + | USP28 | chr11 | 113705057 | - |
5CDS-intron | ENST00000375571 | ENST00000537706 | MAPRE1 | chr20 | 31427662 | + | USP28 | chr11 | 113705057 | - |
5CDS-intron | ENST00000375571 | ENST00000544967 | MAPRE1 | chr20 | 31427662 | + | USP28 | chr11 | 113705057 | - |
5CDS-intron | ENST00000375571 | ENST00000545540 | MAPRE1 | chr20 | 31427662 | + | USP28 | chr11 | 113705057 | - |
In-frame | ENST00000375571 | ENST00000003302 | MAPRE1 | chr20 | 31427662 | + | USP28 | chr11 | 113705057 | - |
In-frame | ENST00000375571 | ENST00000260188 | MAPRE1 | chr20 | 31427662 | + | USP28 | chr11 | 113705057 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000375571 | MAPRE1 | chr20 | 31427662 | + | ENST00000003302 | USP28 | chr11 | 113705057 | - | 4802 | 736 | 139 | 3435 | 1098 |
ENST00000375571 | MAPRE1 | chr20 | 31427662 | + | ENST00000260188 | USP28 | chr11 | 113705057 | - | 4704 | 736 | 139 | 3339 | 1066 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000375571 | ENST00000003302 | MAPRE1 | chr20 | 31427662 | + | USP28 | chr11 | 113705057 | - | 0.000653763 | 0.9993462 |
ENST00000375571 | ENST00000260188 | MAPRE1 | chr20 | 31427662 | + | USP28 | chr11 | 113705057 | - | 0.000528986 | 0.999471 |
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Fusion Genomic Features for MAPRE1-USP28 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for MAPRE1-USP28 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:31427662/chr11:113705057) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MAPRE1 | . |
FUNCTION: Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed:28814570, PubMed:34608293). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation (PubMed:12388762, PubMed:34608293). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). May play a role in cell migration (By similarity). {ECO:0000250|UniProtKB:Q61166, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23001180, ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:34608293}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | MAPRE1 | chr20:31427662 | chr11:113705057 | ENST00000375571 | + | 5 | 7 | 14_116 | 199 | 269.0 | Domain | Calponin-homology (CH) |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | MAPRE1 | chr20:31427662 | chr11:113705057 | ENST00000375571 | + | 5 | 7 | 185_255 | 199 | 269.0 | Domain | EB1 C-terminal |
Hgene | MAPRE1 | chr20:31427662 | chr11:113705057 | ENST00000375571 | + | 5 | 7 | 208_268 | 199 | 269.0 | Region | Note=DCTN1-binding |
Hgene | MAPRE1 | chr20:31427662 | chr11:113705057 | ENST00000375571 | + | 5 | 7 | 220_242 | 199 | 269.0 | Region | Note=APC-binding |
Tgene | USP28 | chr20:31427662 | chr11:113705057 | ENST00000003302 | 4 | 25 | 162_650 | 178 | 1078.0 | Domain | Note=USP | |
Tgene | USP28 | chr20:31427662 | chr11:113705057 | ENST00000003302 | 4 | 25 | 97_116 | 178 | 1078.0 | Domain | UIM | |
Tgene | USP28 | chr20:31427662 | chr11:113705057 | ENST00000260188 | 4 | 24 | 162_650 | 178 | 1046.0 | Domain | Note=USP | |
Tgene | USP28 | chr20:31427662 | chr11:113705057 | ENST00000260188 | 4 | 24 | 97_116 | 178 | 1046.0 | Domain | UIM |
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Fusion Gene Sequence for MAPRE1-USP28 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>51655_51655_1_MAPRE1-USP28_MAPRE1_chr20_31427662_ENST00000375571_USP28_chr11_113705057_ENST00000003302_length(transcript)=4802nt_BP=736nt CTTTACGTCGGCGCGTAACGAGGGGGTGCGTGTGAGGTCATCGCGCGGGCGGGCGGGCGGGGTCTGGCGGTTTGAACGAGACGAAGACGG AACCGGAGCCGGTTGCGGGCAGTGGACGCGGTTCTGCCGAGAGCCGAAGATGGCAGTGAACGTATACTCAACGTCAGTGACCAGTGATAA CCTAAGTCGACATGACATGCTGGCCTGGATCAATGAGTCTCTGCAGTTGAATCTGACAAAGATCGAACAGTTGTGCTCAGGGGCTGCGTA TTGTCAGTTTATGGACATGCTGTTCCCTGGCTCCATTGCCTTGAAGAAAGTGAAATTCCAAGCTAAGCTAGAACACGAGTACATCCAGAA CTTCAAAATACTACAAGCAGGTTTTAAGAGAATGGGTGTTGACAAAATAATTCCTGTGGACAAATTAGTAAAAGGAAAGTTTCAGGACAA TTTTGAATTCGTTCAGTGGTTCAAGAAGTTTTTCGATGCAAACTATGATGGAAAAGACTATGACCCTGTGGCTGCCAGACAAGGTCAAGA AACTGCAGTGGCTCCTTCCCTTGTTGCTCCAGCTCTGAATAAACCGAAGAAACCTCTCACTTCTAGCAGTGCAGCTCCCCAGAGGCCCAT CTCAACACAGAGAACCGCTGCGGCTCCTAAGGCTGGCCCTGGTGTGGTGCGAAAGAACCCTGGTGTGGGCAACGGAGACGACGAGGCAGC TGAGTTGATGCAGCAGTCTCTCTTTCAATTGCCTGAATTTCGAAGACTTGTTCTCAGTTATAGTCTGCCACAAAATGTACTTGAAAATTG TCGAAGTCATACAGAAAAGAGAAATATCATGTTTATGCAAGAGCTTCAGTATTTGTTTGCTCTAATGATGGGATCAAATAGAAAATTTGT AGACCCGTCTGCAGCCCTGGATCTATTAAAGGGAGCATTCCGATCATCTGAGGAACAGCAGCAAGATGTGAGTGAATTCACACACAAGCT CCTGGATTGGCTAGAGGACGCATTCCAGCTAGCTGTTAATGTTAACAGTCCCAGGAACAAATCTGAAAATCCAATGGTGCAGCTGTTCTA TGGTACTTTCCTGACTGAAGGGGTTCGTGAAGGAAAACCCTTTTGTAACAATGAGACCTTCGGCCAGTATCCTCTTCAGGTAAACGGTTA TCGCAACTTAGACGAGTGTTTGGAAGGGGCCATGGTGGAGGGTGATGTTGAGCTTCTTCCCTCCGATCACTCGGTGAAGTATGGACAAGA GCGTTGGTTTACAAAGCTACCTCCAGTGTTGACCTTTGAACTCTCAAGATTTGAGTTTAATCAGTCCCTTGGGCAGCCAGAGAAAATTCA CAATAAGCTGGAATTTCCTCAGATTATTTATATGGACAGGTACATGTACAGGAGCAAGGAGCTTATTCGAAATAAGAGAGAGTGTATTCG AAAGTTGAAGGAGGAAATAAAAATTCTGCAGCAAAAATTGGAAAGGTATGTGAAATATGGCTCAGGCCCAGCTCGGTTCCCGCTCCCGGA CATGCTGAAATATGTTATTGAATTTGCTAGTACAAAACCTGCCTCAGAAAGCTGTCCACCTGAAAGTGACACACATATGACATTACCACT TTCTTCAGTGCACTGCTCGGTTTCTGACCAGACATCCAAGGAAAGTACAAGTACAGAAAGCTCTTCTCAGGATGTTGAAAGTACCTTTTC TTCTCCTGAAGATTCTTTACCCAAGTCTAAACCACTGACATCTTCTCGGTCTTCCATGGAAATGCCTTCACAGCCAGCTCCACGAACAGT CACAGATGAGGAGATAAATTTTGTTAAGACCTGTCTTCAGAGATGGAGGAGTGAGATTGAACAAGATATACAAGATTTAAAGACTTGTAT TGCAAGTACTACTCAGACTATTGAACAGATGTACTGCGATCCTCTCCTTCGTCAGGTGCCTTATCGCTTGCATGCAGTTCTTGTTCATGA AGGACAAGCAAATGCTGGACACTATTGGGCCTATATCTATAATCAACCCCGACAGAGCTGGCTCAAGTACAATGACATCTCTGTTACTGA ATCTTCCTGGGAAGAAGTTGAAAGAGATTCCTATGGAGGCCTGAGAAATGTTAGTGCTTACTGTCTGATGTACATTAATGACAAACTACC CTACTTCAATGCAGAGGCAGCCCCAACTGAATCAGATCAAATGTCAGAAGTGGAAGCCCTATCTGTGGAACTCAAGCATTACATTCAGGA GGATAACTGGCGGTTTGAGCAGGAAGTAGAGGAGTGGGAAGAAGAGCAGTCTTGCAAAATCCCTCAAATGGAGTCCTCCACCAACTCCTC ATCACAGGACTACTCTACATCACAAGAGCCTTCAGTAGCCTCTTCTCATGGGGTTCGCTGCTTGTCGTCTGAGCATGCTGTGATTGTAAA GGAGCAAACTGCCCAGGCTATTGCAAACACAGCCCGTGCCTATGAGAAGAGCGGTGTAGAAGCGGCACTGAGTGAGGTGATGCTGAGCCC TGCCATGCAAGGGGTCATCCTGGCCATAGCTAAAGCCCGTCAGACCTTTGACCGAGATGGGTCTGAAGCAGGGCTGATTAAGGCATTCCA TGAAGAATACTCCAGGCTCTATCAGCTTGCCAAAGAGACCCCCACCTCTCACAGTGATCCTCGACTTCAGCATGTCCTTGTCTACTTTTT CCAAAATGAAGCACCCAAAAGGGTAGTAGAACGAACCCTTCTGGAACAGTTTGCAGATAAAAATCTTAGCTATGATGAAAGATCAATCAG CATTATGAAGGTGGCTCAAGCGAAACTGAAGGAAATTGGTCCAGATGACATGAATATGGAAGAGTACAAGAAGTGGCATGAAGATTATAG TTTGTTCCGAAAAGTGTCTGTGTATCTCCTAACAGGCCTAGAACTCTATCAAAAAGGAAAGTACCAAGAGGCACTTTCCTACCTGGTATA TGCCTACCAGAGCAATGCTGCCCTGCTGATGAAGGGGCCCCGCCGGGGGGTCAAAGAATCCGTGATTGCTTTATACCGAAGAAAATGCCT TCTGGAGCTGAATGCCAAAGCAGCTTCTCTTTTTGAAACAAATGATGATCACTCCGTAACTGAGGGCATTAATGTGATGAATGAACTGAT CATCCCCTGCATTCACCTTATCATTAATAATGACATTTCCAAGGATGATCTGGATGCCATTGAGGTCATGAGAAACCATTGGTGCTCTTA CCTTGGGCAAGATATTGCAGAAAATCTGCAGCTGTGCCTAGGGGAGTTTCTACCCAGACTTCTAGATCCTTCTGCAGAAATCATCGTCTT GAAAGAGCCTCCAACAATTCGACCCAATTCTCCCTATGACCTATGTAGCCGATTTGCAGCTGTCATGGAGTCAATTCAGGGAGTTTCAAC TGTGACAGTGAAATAAGCTCCCACATGTTCAAGGCCCATTCTGGTTCCTGGCTGCCTGCCTCTTGCACAGAAGTTCGTTGTCATAGTGCT CACCTTGGGAAAAGGATTAGGTGGGCACATAAGATTCCGATCAGACCCCAACCATGCTGCATGTGTAAAGAAGGATTGAAAATAAAATTG CACTTTTTAGGTACAAAATCATAAAAGCTGTTTCACTAGAAAAGGCAGAAAGCAGTGTATTAAGGTGTTGAATTACGCCAGAAGACCTGA AATGCCTTGTACCTACAACAATGCTTAGGCTTTTCTAAGCCTCTTGCCACTTTTAAAATTATCCTTCAGGCATAAATATTTTTGACAGCA GAATAGAAGAATGATTCATGAGAACCTGAACCAGATGAACAGCTACTAGTTATTTTATCAAATACAGATGACATTTAAAAATTCTTAACT ACAAGAGATTAGAAATATAAACCTTGCCTGGCTCTTGCCAGGAGATAACAAAATGGGTTGCTGATGAACTGCACCCTTTTACATGTGGGT AGAATATAAGCTCACATGGCAGTGAGATGTTGAAAAGTCAAAAGAGACCTGTCTCTCTCCTTTCTTTTCTATCTTTAAACCAGAAAACCT CATACTCAGTCCTCAGTGAAAGAAAGTAAAGTATTAAGGACTTTAGACAGAAGAGCATTGTGTAACTTGACTGAAGATCATCCATTAATA GTTATTAGGCATTTAGGTAAAATTTTCTAATACCTAAAAATTGTCAAAAACAGTCAATAGGGCTACTGCTGGCCCAAAGACCATTTAGGT CCACCTCCTCTTTTTTGCTCTTTTTTTTTTTCTGTGACAGTTTCACTGTGTCGCCCAGGCTGGCGTTCAGTGGTGCAATCTCAGCTCACT GCAAACTCTGTCTCCTGGGCTCAAGTGATTCTCGTGCCTCAGCCTCCCGAATAGCTGGAATTACGGGCATGCACCACCACACCTGGCTAA TTTTTGTATTTTTAATAGAGATGGGGTTTCACCATATTGGCCAGGCTGATCTCTAACTCCTGGCCTCAAGTGATCTATCTGCCTCCCTCA GCCTCCCAAAGTCTGGGATTGCAGACAAGTCATCGTACCCGGCCTTCTTTTTTGCCCTTAAAAGTAAGGGATGTGGGTTTGTACAAAAAA AAAAAAAAAAAAAAAAAAACCAGCATACATATGCAAAACTATATATATATGTATATGTAGAGAAAAATACTTCCCATTGATCATTTTTAA AAGGCTTCTGATTGGATATTGTGTTTTAACCAAATTTTAAAGATTAATGGAATCATGAAAGGGAAAAAAATTGATACAACTATGCAGATT >51655_51655_1_MAPRE1-USP28_MAPRE1_chr20_31427662_ENST00000375571_USP28_chr11_113705057_ENST00000003302_length(amino acids)=1098AA_BP=198 MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKI IPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAARQGQETAVAPSLVAPALNKPKKPLTSSSAAPQRPISTQRTAAAPKAGPGVV RKNPGVGNGDDEAAELMQQSLFQLPEFRRLVLSYSLPQNVLENCRSHTEKRNIMFMQELQYLFALMMGSNRKFVDPSAALDLLKGAFRSS EEQQQDVSEFTHKLLDWLEDAFQLAVNVNSPRNKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQVNGYRNLDECLEGAMVEGDV ELLPSDHSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIYMDRYMYRSKELIRNKRECIRKLKEEIKILQQKLERY VKYGSGPARFPLPDMLKYVIEFASTKPASESCPPESDTHMTLPLSSVHCSVSDQTSKESTSTESSSQDVESTFSSPEDSLPKSKPLTSSR SSMEMPSQPAPRTVTDEEINFVKTCLQRWRSEIEQDIQDLKTCIASTTQTIEQMYCDPLLRQVPYRLHAVLVHEGQANAGHYWAYIYNQP RQSWLKYNDISVTESSWEEVERDSYGGLRNVSAYCLMYINDKLPYFNAEAAPTESDQMSEVEALSVELKHYIQEDNWRFEQEVEEWEEEQ SCKIPQMESSTNSSSQDYSTSQEPSVASSHGVRCLSSEHAVIVKEQTAQAIANTARAYEKSGVEAALSEVMLSPAMQGVILAIAKARQTF DRDGSEAGLIKAFHEEYSRLYQLAKETPTSHSDPRLQHVLVYFFQNEAPKRVVERTLLEQFADKNLSYDERSISIMKVAQAKLKEIGPDD MNMEEYKKWHEDYSLFRKVSVYLLTGLELYQKGKYQEALSYLVYAYQSNAALLMKGPRRGVKESVIALYRRKCLLELNAKAASLFETNDD HSVTEGINVMNELIIPCIHLIINNDISKDDLDAIEVMRNHWCSYLGQDIAENLQLCLGEFLPRLLDPSAEIIVLKEPPTIRPNSPYDLCS -------------------------------------------------------------- >51655_51655_2_MAPRE1-USP28_MAPRE1_chr20_31427662_ENST00000375571_USP28_chr11_113705057_ENST00000260188_length(transcript)=4704nt_BP=736nt CTTTACGTCGGCGCGTAACGAGGGGGTGCGTGTGAGGTCATCGCGCGGGCGGGCGGGCGGGGTCTGGCGGTTTGAACGAGACGAAGACGG AACCGGAGCCGGTTGCGGGCAGTGGACGCGGTTCTGCCGAGAGCCGAAGATGGCAGTGAACGTATACTCAACGTCAGTGACCAGTGATAA CCTAAGTCGACATGACATGCTGGCCTGGATCAATGAGTCTCTGCAGTTGAATCTGACAAAGATCGAACAGTTGTGCTCAGGGGCTGCGTA TTGTCAGTTTATGGACATGCTGTTCCCTGGCTCCATTGCCTTGAAGAAAGTGAAATTCCAAGCTAAGCTAGAACACGAGTACATCCAGAA CTTCAAAATACTACAAGCAGGTTTTAAGAGAATGGGTGTTGACAAAATAATTCCTGTGGACAAATTAGTAAAAGGAAAGTTTCAGGACAA TTTTGAATTCGTTCAGTGGTTCAAGAAGTTTTTCGATGCAAACTATGATGGAAAAGACTATGACCCTGTGGCTGCCAGACAAGGTCAAGA AACTGCAGTGGCTCCTTCCCTTGTTGCTCCAGCTCTGAATAAACCGAAGAAACCTCTCACTTCTAGCAGTGCAGCTCCCCAGAGGCCCAT CTCAACACAGAGAACCGCTGCGGCTCCTAAGGCTGGCCCTGGTGTGGTGCGAAAGAACCCTGGTGTGGGCAACGGAGACGACGAGGCAGC TGAGTTGATGCAGCAGTCTCTCTTTCAATTGCCTGAATTTCGAAGACTTGTTCTCAGTTATAGTCTGCCACAAAATGTACTTGAAAATTG TCGAAGTCATACAGAAAAGAGAAATATCATGTTTATGCAAGAGCTTCAGTATTTGTTTGCTCTAATGATGGGATCAAATAGAAAATTTGT AGACCCGTCTGCAGCCCTGGATCTATTAAAGGGAGCATTCCGATCATCTGAGGAACAGCAGCAAGATGTGAGTGAATTCACACACAAGCT CCTGGATTGGCTAGAGGACGCATTCCAGCTAGCTGTTAATGTTAACAGTCCCAGGAACAAATCTGAAAATCCAATGGTGCAGCTGTTCTA TGGTACTTTCCTGACTGAAGGGGTTCGTGAAGGAAAACCCTTTTGTAACAATGAGACCTTCGGCCAGTATCCTCTTCAGGTAAACGGTTA TCGCAACTTAGACGAGTGTTTGGAAGGGGCCATGGTGGAGGGTGATGTTGAGCTTCTTCCCTCCGATCACTCGGTGAAGTATGGACAAGA GCGTTGGTTTACAAAGCTACCTCCAGTGTTGACCTTTGAACTCTCAAGATTTGAGTTTAATCAGTCCCTTGGGCAGCCAGAGAAAATTCA CAATAAGCTGGAATTTCCTCAGATTATTTATATGGACAGGTACATGTACAGGAGCAAGGAGCTTATTCGAAATAAGAGAGAGTGTATTCG AAAGTTGAAGGAGGAAATAAAAATTCTGCAGCAAAAATTGGAAAGGTATGTGAAATATGGCTCAGGCCCAGCTCGGTTCCCGCTCCCGGA CATGCTGAAATATGTTATTGAATTTGCTAGTACAAAACCTGCCTCAGAAAGCTGTCCACCTGAAAGTGACACACATATGACATTACCACT TTCTTCAGTGCACTGCTCGGTTTCTGACCAGACATCCAAGGAAAGTACAAGTACAGAAAGCTCTTCTCAGGATGTTGAAAGTACCTTTTC TTCTCCTGAAGATTCTTTACCCAAGTCTAAACCACTGACATCTTCTCGGTCTTCCATGGAAATGCCTTCACAGCCAGCTCCACGAACAGT CACAGATGAGGAGATAAATTTTGTTAAGACCTGTCTTCAGAGATGGAGGAGTGAGATTGAACAAGATATACAAGATTTAAAGACTTGTAT TGCAAGTACTACTCAGACTATTGAACAGATGTACTGCGATCCTCTCCTTCGTCAGGTGCCTTATCGCTTGCATGCAGTTCTTGTTCATGA AGGACAAGCAAATGCTGGACACTATTGGGCCTATATCTATAATCAACCCCGACAGAGCTGGCTCAAGTACAATGACATCTCTGTTACTGA ATCTTCCTGGGAAGAAGTTGAAAGAGATTCCTATGGAGGCCTGAGAAATGTTAGTGCTTACTGTCTGATGTACATTAATGACAAACTACC CTACTTCAATGCAGAGGCAGCCCCAACTGAATCAGATCAAATGTCAGAAGTGGAAGCCCTATCTGTGGAACTCAAGCATTACATTCAGGA GGATAACTGGCGGTTTGAGCAGGAAGTAGAGGAGTGGGAAGAAGAGCAGTCTTGCAAAATCCCTCAAATGGAGTCCTCCACCAACTCCTC ATCACAGGACTACTCTACATCACAAGAGCCTTCAGTAGCCTCTTCTCATGGGGTTCGCTGCTTGTCGTCTGAGCATGCTGTGATTGTAAA GGAGCAAACTGCCCAGGCTATTGCAAACACAGCCCGTGCCTATGAGAAGAGCGGTGTAGAAGCGGCACTGAGTGAGGCATTCCATGAAGA ATACTCCAGGCTCTATCAGCTTGCCAAAGAGACCCCCACCTCTCACAGTGATCCTCGACTTCAGCATGTCCTTGTCTACTTTTTCCAAAA TGAAGCACCCAAAAGGGTAGTAGAACGAACCCTTCTGGAACAGTTTGCAGATAAAAATCTTAGCTATGATGAAAGATCAATCAGCATTAT GAAGGTGGCTCAAGCGAAACTGAAGGAAATTGGTCCAGATGACATGAATATGGAAGAGTACAAGAAGTGGCATGAAGATTATAGTTTGTT CCGAAAAGTGTCTGTGTATCTCCTAACAGGCCTAGAACTCTATCAAAAAGGAAAGTACCAAGAGGCACTTTCCTACCTGGTATATGCCTA CCAGAGCAATGCTGCCCTGCTGATGAAGGGGCCCCGCCGGGGGGTCAAAGAATCCGTGATTGCTTTATACCGAAGAAAATGCCTTCTGGA GCTGAATGCCAAAGCAGCTTCTCTTTTTGAAACAAATGATGATCACTCCGTAACTGAGGGCATTAATGTGATGAATGAACTGATCATCCC CTGCATTCACCTTATCATTAATAATGACATTTCCAAGGATGATCTGGATGCCATTGAGGTCATGAGAAACCATTGGTGCTCTTACCTTGG GCAAGATATTGCAGAAAATCTGCAGCTGTGCCTAGGGGAGTTTCTACCCAGACTTCTAGATCCTTCTGCAGAAATCATCGTCTTGAAAGA GCCTCCAACAATTCGACCCAATTCTCCCTATGACCTATGTAGCCGATTTGCAGCTGTCATGGAGTCAATTCAGGGAGTTTCAACTGTGAC AGTGAAATAAGCTCCCACATGTTCAAGGCCCATTCTGGTTCCTGGCTGCCTGCCTCTTGCACAGAAGTTCGTTGTCATAGTGCTCACCTT GGGAAAAGGATTAGGTGGGCACATAAGATTCCGATCAGACCCCAACCATGCTGCATGTGTAAAGAAGGATTGAAAATAAAATTGCACTTT TTAGGTACAAAATCATAAAAGCTGTTTCACTAGAAAAGGCAGAAAGCAGTGTATTAAGGTGTTGAATTACGCCAGAAGACCTGAAATGCC TTGTACCTACAACAATGCTTAGGCTTTTCTAAGCCTCTTGCCACTTTTAAAATTATCCTTCAGGCATAAATATTTTTGACAGCAGAATAG AAGAATGATTCATGAGAACCTGAACCAGATGAACAGCTACTAGTTATTTTATCAAATACAGATGACATTTAAAAATTCTTAACTACAAGA GATTAGAAATATAAACCTTGCCTGGCTCTTGCCAGGAGATAACAAAATGGGTTGCTGATGAACTGCACCCTTTTACATGTGGGTAGAATA TAAGCTCACATGGCAGTGAGATGTTGAAAAGTCAAAAGAGACCTGTCTCTCTCCTTTCTTTTCTATCTTTAAACCAGAAAACCTCATACT CAGTCCTCAGTGAAAGAAAGTAAAGTATTAAGGACTTTAGACAGAAGAGCATTGTGTAACTTGACTGAAGATCATCCATTAATAGTTATT AGGCATTTAGGTAAAATTTTCTAATACCTAAAAATTGTCAAAAACAGTCAATAGGGCTACTGCTGGCCCAAAGACCATTTAGGTCCACCT CCTCTTTTTTGCTCTTTTTTTTTTTCTGTGACAGTTTCACTGTGTCGCCCAGGCTGGCGTTCAGTGGTGCAATCTCAGCTCACTGCAAAC TCTGTCTCCTGGGCTCAAGTGATTCTCGTGCCTCAGCCTCCCGAATAGCTGGAATTACGGGCATGCACCACCACACCTGGCTAATTTTTG TATTTTTAATAGAGATGGGGTTTCACCATATTGGCCAGGCTGATCTCTAACTCCTGGCCTCAAGTGATCTATCTGCCTCCCTCAGCCTCC CAAAGTCTGGGATTGCAGACAAGTCATCGTACCCGGCCTTCTTTTTTGCCCTTAAAAGTAAGGGATGTGGGTTTGTACAAAAAAAAAAAA AAAAAAAAAAAAACCAGCATACATATGCAAAACTATATATATATGTATATGTAGAGAAAAATACTTCCCATTGATCATTTTTAAAAGGCT TCTGATTGGATATTGTGTTTTAACCAAATTTTAAAGATTAATGGAATCATGAAAGGGAAAAAAATTGATACAACTATGCAGATTTTATAA >51655_51655_2_MAPRE1-USP28_MAPRE1_chr20_31427662_ENST00000375571_USP28_chr11_113705057_ENST00000260188_length(amino acids)=1066AA_BP=198 MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKI IPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAARQGQETAVAPSLVAPALNKPKKPLTSSSAAPQRPISTQRTAAAPKAGPGVV RKNPGVGNGDDEAAELMQQSLFQLPEFRRLVLSYSLPQNVLENCRSHTEKRNIMFMQELQYLFALMMGSNRKFVDPSAALDLLKGAFRSS EEQQQDVSEFTHKLLDWLEDAFQLAVNVNSPRNKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQVNGYRNLDECLEGAMVEGDV ELLPSDHSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIYMDRYMYRSKELIRNKRECIRKLKEEIKILQQKLERY VKYGSGPARFPLPDMLKYVIEFASTKPASESCPPESDTHMTLPLSSVHCSVSDQTSKESTSTESSSQDVESTFSSPEDSLPKSKPLTSSR SSMEMPSQPAPRTVTDEEINFVKTCLQRWRSEIEQDIQDLKTCIASTTQTIEQMYCDPLLRQVPYRLHAVLVHEGQANAGHYWAYIYNQP RQSWLKYNDISVTESSWEEVERDSYGGLRNVSAYCLMYINDKLPYFNAEAAPTESDQMSEVEALSVELKHYIQEDNWRFEQEVEEWEEEQ SCKIPQMESSTNSSSQDYSTSQEPSVASSHGVRCLSSEHAVIVKEQTAQAIANTARAYEKSGVEAALSEAFHEEYSRLYQLAKETPTSHS DPRLQHVLVYFFQNEAPKRVVERTLLEQFADKNLSYDERSISIMKVAQAKLKEIGPDDMNMEEYKKWHEDYSLFRKVSVYLLTGLELYQK GKYQEALSYLVYAYQSNAALLMKGPRRGVKESVIALYRRKCLLELNAKAASLFETNDDHSVTEGINVMNELIIPCIHLIINNDISKDDLD -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MAPRE1-USP28 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | MAPRE1 | chr20:31427662 | chr11:113705057 | ENST00000375571 | + | 5 | 7 | 185_268 | 199.0 | 269.0 | CDK5RAP2 |
Hgene | MAPRE1 | chr20:31427662 | chr11:113705057 | ENST00000375571 | + | 5 | 7 | 124_268 | 199.0 | 269.0 | MTUS2/TIP150 |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MAPRE1-USP28 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MAPRE1-USP28 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MAPRE1 | C0043094 | Weight Gain | 1 | CTD_human |
Hgene | MAPRE1 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | C0033578 | Prostatic Neoplasms | 2 | CTD_human | |
Tgene | C0376358 | Malignant neoplasm of prostate | 2 | CTD_human |