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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:RAB3GAP1-STK35 (FusionGDB2 ID:HG22930TG140901) |
Fusion Gene Summary for RAB3GAP1-STK35 |
Fusion gene summary |
Fusion gene information | Fusion gene name: RAB3GAP1-STK35 | Fusion gene ID: hg22930tg140901 | Hgene | Tgene | Gene symbol | RAB3GAP1 | STK35 | Gene ID | 22930 | 140901 |
Gene name | RAB3 GTPase activating protein catalytic subunit 1 | serine/threonine kinase 35 | |
Synonyms | P130|RAB3GAP|RAB3GAP130|WARBM1 | CLIK1|STK35L1 | |
Cytomap | ('RAB3GAP1')('STK35') 2q21.3 | 20p13 | |
Type of gene | protein-coding | protein-coding | |
Description | rab3 GTPase-activating protein catalytic subunitRAB3 GTPase activating protein subunit 1 (catalytic)RAB3 GTPase-activating protein 130 kDa subunitrab3-GAP p130 | serine/threonine-protein kinase 35CLIK-1CLP-36 interacting kinaseCLP-36-interacting kinase 1PDLIM1-interacting kinase 1serine threonine kinase 35 long formserine/threonine-protein kinase 35 L1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000264158, ENST00000425393, ENST00000442034, ENST00000539493, ENST00000487003, | ||
Fusion gene scores | * DoF score | 13 X 11 X 9=1287 | 2 X 2 X 2=8 |
# samples | 17 | 2 | |
** MAII score | log2(17/1287*10)=-2.920405402083 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: RAB3GAP1 [Title/Abstract] AND STK35 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | RAB3GAP1(135815656)-STK35(2083414), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | RAB3GAP1-STK35 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RAB3GAP1-STK35 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RAB3GAP1-STK35 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RAB3GAP1-STK35 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RAB3GAP1-STK35 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. RAB3GAP1-STK35 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. RAB3GAP1-STK35 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. RAB3GAP1-STK35 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RAB3GAP1 | GO:0043087 | regulation of GTPase activity | 10859313 |
Fusion gene breakpoints across RAB3GAP1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across STK35 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-CD-8527-01A | RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083414 | + |
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Fusion Gene ORF analysis for RAB3GAP1-STK35 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000264158 | ENST00000246032 | RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083414 | + |
5CDS-5UTR | ENST00000425393 | ENST00000246032 | RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083414 | + |
5CDS-5UTR | ENST00000442034 | ENST00000246032 | RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083414 | + |
5CDS-intron | ENST00000264158 | ENST00000400064 | RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083414 | + |
5CDS-intron | ENST00000425393 | ENST00000400064 | RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083414 | + |
5CDS-intron | ENST00000442034 | ENST00000400064 | RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083414 | + |
5UTR-3CDS | ENST00000539493 | ENST00000381482 | RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083414 | + |
5UTR-5UTR | ENST00000539493 | ENST00000246032 | RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083414 | + |
5UTR-intron | ENST00000539493 | ENST00000400064 | RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083414 | + |
Frame-shift | ENST00000425393 | ENST00000381482 | RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083414 | + |
In-frame | ENST00000264158 | ENST00000381482 | RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083414 | + |
In-frame | ENST00000442034 | ENST00000381482 | RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083414 | + |
intron-3CDS | ENST00000487003 | ENST00000381482 | RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083414 | + |
intron-5UTR | ENST00000487003 | ENST00000246032 | RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083414 | + |
intron-intron | ENST00000487003 | ENST00000400064 | RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083414 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000264158 | RAB3GAP1 | chr2 | 135815656 | + | ENST00000381482 | STK35 | chr20 | 2083414 | + | 6313 | 193 | 43 | 1503 | 486 |
ENST00000442034 | RAB3GAP1 | chr2 | 135815656 | + | ENST00000381482 | STK35 | chr20 | 2083414 | + | 6280 | 160 | 10 | 1470 | 486 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000264158 | ENST00000381482 | RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083414 | + | 0.001235419 | 0.99876463 |
ENST00000442034 | ENST00000381482 | RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083414 | + | 0.001239745 | 0.9987602 |
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Fusion Genomic Features for RAB3GAP1-STK35 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083413 | + | 0.5811445 | 0.4188555 |
RAB3GAP1 | chr2 | 135815656 | + | STK35 | chr20 | 2083413 | + | 0.5811445 | 0.4188555 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RAB3GAP1-STK35 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:135815656/chr20:2083414) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | STK35 | chr2:135815656 | chr20:2083414 | ENST00000246032 | 0 | 4 | 40_187 | 0 | 1893.0 | Compositional bias | Note=Ala-rich | |
Tgene | STK35 | chr2:135815656 | chr20:2083414 | ENST00000246032 | 0 | 4 | 202_530 | 0 | 1893.0 | Domain | Protein kinase | |
Tgene | STK35 | chr2:135815656 | chr20:2083414 | ENST00000381482 | 0 | 4 | 202_530 | 98 | 1937.3333333333333 | Domain | Protein kinase | |
Tgene | STK35 | chr2:135815656 | chr20:2083414 | ENST00000246032 | 0 | 4 | 208_216 | 0 | 1893.0 | Nucleotide binding | ATP | |
Tgene | STK35 | chr2:135815656 | chr20:2083414 | ENST00000381482 | 0 | 4 | 208_216 | 98 | 1937.3333333333333 | Nucleotide binding | ATP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | STK35 | chr2:135815656 | chr20:2083414 | ENST00000381482 | 0 | 4 | 40_187 | 98 | 1937.3333333333333 | Compositional bias | Note=Ala-rich |
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Fusion Gene Sequence for RAB3GAP1-STK35 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>71363_71363_1_RAB3GAP1-STK35_RAB3GAP1_chr2_135815656_ENST00000264158_STK35_chr20_2083414_ENST00000381482_length(transcript)=6313nt_BP=193nt CTTCTTCCCGGCAGCCTTAGCGCCAGGCCCGGCGCTCCTCAAGATGGCTGCCGACAGTGAGCCCGAATCCGAGGTATTTGAGATCACGGA CTTCACCACTGCCTCGGAATGGGAAAGGTTTATTTCCAAAGTTGAAGAAGTCTTGAATGACTGGAAACTGATTGGAAACTCTTTGGGAAA GCCACTCGAAAAGGTCACAATCCAAGGTCCGGCTCCTCCGCGTCCCAGGGCCGGACGGAGGGATGAGGCAGGGGGGGCCCGGGCAGCGCC GTTGCTGCTCCCCCCGCCGCCCGCAGCCATGGAAACGGGGAAGGACGGCGCCCGCAGAGGTACACAAAGCCCGGAGCGGAAAAGGCGAAG CCCAGTGCCGCGGGCGCCCAGCACGAAGCTGAGGCCGGCGGCGGCGGCCCGGGCCATGGATCCGGTGGCGGCCGAGGCCCCGGGCGAGGC CTTCCTGGCGCGGCGACGGCCTGAGGGCGGTGGCGGGTCCGCGCGGCCGCGTTACAGCCTGTTGGCGGAGATCGGGCGCGGCAGCTACGG CGTGGTTTATGAGGCAGTGGCCGGGCGCAGCGGGGCCCGGGTGGCGGTCAAGAAGATCCGCTGCGACGCCCCCGAGAACGTGGAGCTGGC GCTGGCTGAATTCTGGGCCCTCACCAGCCTCAAGCGGCGCCACCAGAACGTCGTGCAGTTTGAGGAGTGCGTCCTGCAGCGCAATGGGTT AGCCCAGCGCATGAGTCACGGCAACAAGAGCTCGCAGCTTTACCTGCGCCTGGTGGAGACCTCGCTGAAAGGAGAAAGGATCCTGGGTTA TGCTGAGGAGCCCTGCTATCTCTGGTTTGTCATGGAGTTCTGTGAAGGTGGAGACCTGAATCAGTATGTCCTGTCCCGGAGGCCAGACCC AGCCACCAACAAAAGTTTCATGCTACAGCTGACGAGCGCCATTGCCTTCCTGCACAAAAACCATATTGTGCACAGGGACCTGAAGCCAGA CAACATCCTCATCACAGAGCGGTCTGGCACCCCCATCCTCAAAGTGGCCGACTTTGGACTAAGCAAGGTCTGTGCTGGGCTGGCACCCCG AGGCAAAGAGGGCAATCAAGACAACAAAAATGTGAATGTGAATAAGTACTGGCTGTCCTCAGCCTGCGGTTCGGACTTCTACATGGCTCC TGAAGTCTGGGAGGGACACTACACAGCCAAGGCGGACATCTTTGCCCTGGGCATTATCATCTGGGCAATGATAGAAAGAATCACTTTTAT TGACTCTGAGACCAAGAAGGAGCTCCTGGGGACCTACATTAAACAGGGGACTGAGATCGTCCCTGTTGGTGAGGCGCTGCTAGAAAACCC AAAGATGGAGTTGCACATCCCCCAAAAACGCAGGACTTCCATGTCTGAGGGGATCAAGCAGCTCTTGAAAGATATGTTAGCTGCTAACCC ACAGGACCGGCCTGATGCCTTTGAACTTGAAACCAGAATGGACCAGGTCACATGTGCTGCTTAAAATTCAGGGCTAAGCATTTTGGGTGA TTTTAAACTAGGTCGATTCCTCGGGACCCACAGTCTCACCACGTCTCCTCCAGAGGACGGCAGAGGGTACAGGTGGTGGCCTGGCCGGTT GGCGATCTCCCGACAGCTGGATCCGGCAATGTGAAGCTTTTGTTTGGGTTTCCCCGCTTCTTTTTAGTTTTGCTTTATTTTTTTCCTTTT CTTTTCTTTTTTTTTTTTCCTCTTTCCTTTTTTTAAATTTAAACCATTGAGACTTCAGAAGAGCAGGACACAATGCTGTGGACAGGCACC AATTTCTTTAAAGAAATTCAATGTGGGCAAGGCATATGTGTAAATTTCACTTTTACTTTTTATAAGGGGTTAGGGAGCTATTTTTGGTTT TGTCCTTCACTTTCCCTCTGTCTTCCTTCTTTATACTTTTCTCAGTTCTACTTATGACACCTCACTTCCCTAGAGAAGGCCTGCCTCCCC ATAGGGAATCTGGGGGTTTCTTCTGGAACGGGGCGTGAGGACACAAGGAGGCCTCTGGGCCACGCCTCCCTACCAGATGCAGGAACTCCT GGACTCCTTGGTGGGCTGGCCCTGGCTAGCCCTTGGGCCTCGGAGATGATCAGAGGTGAAGAACCGCCTGGAAGAGGAAGGCCAGGGTTT GGCCAGGAGAACTAAGAAGGTCTCAACTCCAGGCTTTGTTGTGTTTAAGCTATTGAGAGCCCCAGGCCACACCAGGACTTGCAGTGGTGG GAATCCATTCCTCTTCTGCCCTGTGTTGCAGGGAACTAGGAGGTAAGGGTGGAGGGCGACCATCTCGCTCTTGCTGGCGGTGGAGCAGCC ATCCCTGCCTTTCTGTTGGGAAAAACTGTTGTGCCAAACTCTTGTGTGGAACACAGCTGGGTCTTCAGCAGGCATCTGTCACTGCCGTGA GGTCAGCGCTTCTCACCTAACTGCCTCCTGGATTGTCATCTTCCCAGATGTGTCCCATAGTGTCCAGGTGTCACAGAGACGGCCTGAGGC CCTAAGATCTGGTTGTGACTTTGCCATGATAACAGGGTGTCCTGAACTGGCTGCCGTTGTCGTGTTCTCACAGTGAAGGGCGTGCCCTGT GTGCCGGGGTCCATGGTGTCATATGCAGTGACACACACTGTCAAGCGCCATTTCCCTCACCCCTGGAGACTTACTGTTAGGTGCCTGCCC TCAGTATAGACGTATCCAATGGGAAAACAGCGGACCTGCCCAGAGCAGGGAGGTGTCGTGGAACTGGGTAGACCCCCTGCAGCGTTAGGG GCCCATTTGTGGGCTCGCCACCTTCAGGCTTCCCCAGCCATGACACTTCAGCCCCGCCACCCATGCCTGTCTGCTGCAGCCATCCTTGCA CTCTCCAGCGACACTCTCGCACCTCCCTAGGGGAAGCTTCCCTCCCCCTGGGCTGCTGCTCTGAGCCCATCTGTTCTCCCCCTGCAAGAA GGGGCAATGCTCTTGTGTTGTCCCTCTGTCTGGACGCGCCTGGCCACTCCGAAGGCTTTTCACCCCATTATGGCCAAATAGTATAGGGCC ACTGGGGAGGGGGAAGGGAATCATTTTGTGTTCATTTTTGTTTTCTGTTTCACCTAAACCAGCATAGGATTGATAGGGGAGACGGTTGGC GGGCATTTCCGTTTCTATGTGACCAAGGCAGCAGGGGCTTTTACCTGCTAAGCGGCAATCCTTTGGCCCTGAGAATTTGGGAGAGAACAG TGCATCAGGCCAGGCTCAGCAATATGTTTGCTCACATTCTTTCAGCCTTCTGTCACCCCCCTCAACACCAAACTTTCTTCCTTGTGAGCA GAAGGTTGGCTGCTGTTAGCAGGATCCCACAGTGATAACCAGGCCCTTCCCTTCCTAAGCCAAAACCCATTGTGACTGCCTGTCTCTCCT GTCTCTGACTTCTCAGGCAGCCTCCTGAGTGCACTGAGTTGTATCCGAGAGGGTGGGAACAGCAGCATCCCCTAATTGCAGTACACGGTT CCTTTTCCGCCCGCCACCCTGCCTTTCCTTGGGGGCAGCTGTCTCTCTGTACATGAGCAAATGGGCAAAAACAGTCCCCAAACCCAGCAC CCCCCTCTCCCTGGCTGCAGCCCACACTGTAACATCCCTAGTGAGGCTCCAGCCTAATGAGCCCCTTATTTTCTTTTTTTTCCCTCCCCA GGTCTAGTAGCTCTAACTAAAAAGTTCTTGGAGCCATCGTGCTCCCCCTTTGTTATTTTTCTTGCTATCAGAGTAGCAAGAAACAGCACC CCTGTAGGTGACAGGTGGGCAGCCTGGTAGGGGTCGCCAGCCTCCATGCCCCCTCATCTTCCAGTTCTTGCTTAGTGGCACGACCTCTTT CCATAGCATAAATGCAGGCCAGCGTTTTAGCCCCAAGTGCCTGCCCTTGCTTCTTACCCCTCCCCTGCTTTCTCAAACACTTGCCCACCT CAGGCACTCAGCGGGCTCCGCCGTGGTGAGAGAACTGGCCGTGGCTCAGCCCCGGGTAGCACCTGTAGTTTCAGTGCCACTCTCCACTGT CCCCTTGTGGACCAGCTTCCACTCACTGTCACGTCCCCCCTCCTGCGTCTTCACTGGGTCTCAGGCTGCCAGCAGCTCTCTGGTGCATCG TCTCAACACCACCAAGTTTGTAGGACCTGCCCAAGTTCTAGTAGTATTCAAAACTTCAAACGGCAGTCATTTGTTCTCCTCGGCTCTGTG GCAAGGATAGCCCTTTGGAGGGGGACTCTTGACCTCGGCTGTTAGGGATCTGAACTTGGTTTTCCCGTCAGAAGAATCAGCAGGACAGAT CGTAGTGCCTTATTCCATTGTCCTCCCCTGGCCAGGCCTCCTGGCTCAGCTGGAAGTGCATGGCTTCTTTCTCCCTATCTGTGTCCTCTG TCACTTGCTCTTTCACTCTCTCTCTCATTCCCAGAGAGCCACGGGGGAGGGATCACCCTCACCCCCAACACCCTCTTCCTGAGGGCTGTA GCCAGGTCCGCATCTCCCCACCACCACCAGGGCACTCACTCGCAGCTATAGCCCAGGACAGAAAAACTGTGCTTTGGACAGGTGCACACT CTCTGCCTCTTACCTCTAGCCAGGAGGATGCCTCAGTCTGTTCATTCGAGACTGGCCCCGTCTGAACCTTCTCTGGGCACTGGGGACTAA GGTTGCAGGCCTTAGCCTCGTCTCGTCCCAGAGGCATTGGATCAGGAGAATGGGAATTTTTTTCCTCCCACCTGGACATAGTTTGCCCCT GTGGCTGCCTTTCTGAGGGAGTATACTAAATGTTTACTTAAGAAACACCCTGTTTACAGCCAGAGGAGAAACACCCAACACTGAGTGGAG ATTTGACTCTGGACAGGGCCTGGCCTCCTTAGTGGCACTGCCGGGGGGCCCCAGAGCGAATGAGGGCAGAGATGCCCGGGGCAGGGGCAA ACGCCCTCCGCTCCCTCTGCTCCCAACCCTGTGGTGCTAGGACCACTCCCCGCCTTCCCTACGGCCTCCTCGCCCTGCACATTCCCCACC TCCACATTCCCCTCCTCCAAGATCTCAGCTCCTTAACATATCAGTTGTCTCCTAGCCTAGAAAACCAGTGTTTGGAGCAATAAGATGATT ATTTTTGCTTGAATCTTTTTCTAAGAGAAGGAAAAGAGCTGGCATTGTGGGAATTTTCTTTTTATGCTGTTAGCTGTTTACCTTCTTAGA AGACATCCTAATAGGATGGATGTCTGGGTTTTAGCCTTGGGGTATCTTTTGGAAACTTAGAAAAGCAGGAGTCAGGCTGCCACCCCCTAA GGAGGGACCCTAACGTTCTGCCCTTGCCTGGTTCCATATGGCTCCTTCCAGCCCTGCCCACCAAGTGCAGCTCCCACTTTCCATCCTGCC CATACGCCCCTCTTCCCCCGACATCTGGGGGCGCTGGTGGCACTTACTCTAGGTTGGTCTCAGACTATCCCTCCCCTTGGCTGGTTTTCC CTCCTAGGCCTGTCTGGCAGCCCCCAGACAGACGTAGCTCCTGGGAGTCTCGGCCCTGGCAACCTTGGAAGAGCCAAGCTGACATTGTTT AGCTCTTCAGGCCACTGGGTTTTGGAGGCAGAAGTCCAGAGATACTGGCTCTGCCAAGCTGTCGTACTGGGCTGTGGCACAGCCTTCGAG ACAACACGGGTGTATCTCTGATCCTGCCCTACCTAGGCTTCAAGGGGCTTCTGTCTGGAGAAATGCCCTCAAAGGGTAACCAGTAGGTGT GGCATTGAATTGGCCAGTGTTAGCATCTACAGCCATCACCGAGATGAGTCCACTGCCGTTGCCTGCCCGAGGGCCCCCTAAGGTTATAGA CGGTATCAGCAGGGAGGCCGTCCCGCTGGTTTTCTAGGAGAGCCCACAGGAGGAAGGGAGCCTCTTCAGGGGCACTGGAATCTTTTGTGC CAGGGGCTTCTTTTCATCAGAGCCGGGGAGTACATTGCAGTGACTTCTTAAACATTTGTGTGGGACAGACGAGCGTGAGGGAGGTTTTAA GCCAGGCACAAAGTTAGTTTCCAATACTAGTTAATAAATCTATTTTTCTTCATTTCCTTTTTTTGCACAGAAGCTGGTAATCTAGGACCT ACGTGTGAACAACTTTATATGAATATTTTTTGTACTTGGTTTACTTGGGTTGGTATGATACATTATATTTAAGTTCCTTGAACACTGTGG ATCCCCTAATGTGTATGAATGACTGAGGCTTTGTAAATTAAGGGACGTTTGTGTGAATAAAGTTATTTGATGGGGTCAAAGAAGCCATAT >71363_71363_1_RAB3GAP1-STK35_RAB3GAP1_chr2_135815656_ENST00000264158_STK35_chr20_2083414_ENST00000381482_length(amino acids)=486AA_BP=40 MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSLGKPLEKVTIQGPAPPRPRAGRRDEAGGARAAPLLLPPPPAAMETGK DGARRGTQSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARV AVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFC EGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVN KYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSM -------------------------------------------------------------- >71363_71363_2_RAB3GAP1-STK35_RAB3GAP1_chr2_135815656_ENST00000442034_STK35_chr20_2083414_ENST00000381482_length(transcript)=6280nt_BP=160nt GCTCCTCAAGATGGCTGCCGACAGTGAGCCCGAATCCGAGGTATTTGAGATCACGGACTTCACCACTGCCTCGGAATGGGAAAGGTTTAT TTCCAAAGTTGAAGAAGTCTTGAATGACTGGAAACTGATTGGAAACTCTTTGGGAAAGCCACTCGAAAAGGTCACAATCCAAGGTCCGGC TCCTCCGCGTCCCAGGGCCGGACGGAGGGATGAGGCAGGGGGGGCCCGGGCAGCGCCGTTGCTGCTCCCCCCGCCGCCCGCAGCCATGGA AACGGGGAAGGACGGCGCCCGCAGAGGTACACAAAGCCCGGAGCGGAAAAGGCGAAGCCCAGTGCCGCGGGCGCCCAGCACGAAGCTGAG GCCGGCGGCGGCGGCCCGGGCCATGGATCCGGTGGCGGCCGAGGCCCCGGGCGAGGCCTTCCTGGCGCGGCGACGGCCTGAGGGCGGTGG CGGGTCCGCGCGGCCGCGTTACAGCCTGTTGGCGGAGATCGGGCGCGGCAGCTACGGCGTGGTTTATGAGGCAGTGGCCGGGCGCAGCGG GGCCCGGGTGGCGGTCAAGAAGATCCGCTGCGACGCCCCCGAGAACGTGGAGCTGGCGCTGGCTGAATTCTGGGCCCTCACCAGCCTCAA GCGGCGCCACCAGAACGTCGTGCAGTTTGAGGAGTGCGTCCTGCAGCGCAATGGGTTAGCCCAGCGCATGAGTCACGGCAACAAGAGCTC GCAGCTTTACCTGCGCCTGGTGGAGACCTCGCTGAAAGGAGAAAGGATCCTGGGTTATGCTGAGGAGCCCTGCTATCTCTGGTTTGTCAT GGAGTTCTGTGAAGGTGGAGACCTGAATCAGTATGTCCTGTCCCGGAGGCCAGACCCAGCCACCAACAAAAGTTTCATGCTACAGCTGAC GAGCGCCATTGCCTTCCTGCACAAAAACCATATTGTGCACAGGGACCTGAAGCCAGACAACATCCTCATCACAGAGCGGTCTGGCACCCC CATCCTCAAAGTGGCCGACTTTGGACTAAGCAAGGTCTGTGCTGGGCTGGCACCCCGAGGCAAAGAGGGCAATCAAGACAACAAAAATGT GAATGTGAATAAGTACTGGCTGTCCTCAGCCTGCGGTTCGGACTTCTACATGGCTCCTGAAGTCTGGGAGGGACACTACACAGCCAAGGC GGACATCTTTGCCCTGGGCATTATCATCTGGGCAATGATAGAAAGAATCACTTTTATTGACTCTGAGACCAAGAAGGAGCTCCTGGGGAC CTACATTAAACAGGGGACTGAGATCGTCCCTGTTGGTGAGGCGCTGCTAGAAAACCCAAAGATGGAGTTGCACATCCCCCAAAAACGCAG GACTTCCATGTCTGAGGGGATCAAGCAGCTCTTGAAAGATATGTTAGCTGCTAACCCACAGGACCGGCCTGATGCCTTTGAACTTGAAAC CAGAATGGACCAGGTCACATGTGCTGCTTAAAATTCAGGGCTAAGCATTTTGGGTGATTTTAAACTAGGTCGATTCCTCGGGACCCACAG TCTCACCACGTCTCCTCCAGAGGACGGCAGAGGGTACAGGTGGTGGCCTGGCCGGTTGGCGATCTCCCGACAGCTGGATCCGGCAATGTG AAGCTTTTGTTTGGGTTTCCCCGCTTCTTTTTAGTTTTGCTTTATTTTTTTCCTTTTCTTTTCTTTTTTTTTTTTCCTCTTTCCTTTTTT TAAATTTAAACCATTGAGACTTCAGAAGAGCAGGACACAATGCTGTGGACAGGCACCAATTTCTTTAAAGAAATTCAATGTGGGCAAGGC ATATGTGTAAATTTCACTTTTACTTTTTATAAGGGGTTAGGGAGCTATTTTTGGTTTTGTCCTTCACTTTCCCTCTGTCTTCCTTCTTTA TACTTTTCTCAGTTCTACTTATGACACCTCACTTCCCTAGAGAAGGCCTGCCTCCCCATAGGGAATCTGGGGGTTTCTTCTGGAACGGGG CGTGAGGACACAAGGAGGCCTCTGGGCCACGCCTCCCTACCAGATGCAGGAACTCCTGGACTCCTTGGTGGGCTGGCCCTGGCTAGCCCT TGGGCCTCGGAGATGATCAGAGGTGAAGAACCGCCTGGAAGAGGAAGGCCAGGGTTTGGCCAGGAGAACTAAGAAGGTCTCAACTCCAGG CTTTGTTGTGTTTAAGCTATTGAGAGCCCCAGGCCACACCAGGACTTGCAGTGGTGGGAATCCATTCCTCTTCTGCCCTGTGTTGCAGGG AACTAGGAGGTAAGGGTGGAGGGCGACCATCTCGCTCTTGCTGGCGGTGGAGCAGCCATCCCTGCCTTTCTGTTGGGAAAAACTGTTGTG CCAAACTCTTGTGTGGAACACAGCTGGGTCTTCAGCAGGCATCTGTCACTGCCGTGAGGTCAGCGCTTCTCACCTAACTGCCTCCTGGAT TGTCATCTTCCCAGATGTGTCCCATAGTGTCCAGGTGTCACAGAGACGGCCTGAGGCCCTAAGATCTGGTTGTGACTTTGCCATGATAAC AGGGTGTCCTGAACTGGCTGCCGTTGTCGTGTTCTCACAGTGAAGGGCGTGCCCTGTGTGCCGGGGTCCATGGTGTCATATGCAGTGACA CACACTGTCAAGCGCCATTTCCCTCACCCCTGGAGACTTACTGTTAGGTGCCTGCCCTCAGTATAGACGTATCCAATGGGAAAACAGCGG ACCTGCCCAGAGCAGGGAGGTGTCGTGGAACTGGGTAGACCCCCTGCAGCGTTAGGGGCCCATTTGTGGGCTCGCCACCTTCAGGCTTCC CCAGCCATGACACTTCAGCCCCGCCACCCATGCCTGTCTGCTGCAGCCATCCTTGCACTCTCCAGCGACACTCTCGCACCTCCCTAGGGG AAGCTTCCCTCCCCCTGGGCTGCTGCTCTGAGCCCATCTGTTCTCCCCCTGCAAGAAGGGGCAATGCTCTTGTGTTGTCCCTCTGTCTGG ACGCGCCTGGCCACTCCGAAGGCTTTTCACCCCATTATGGCCAAATAGTATAGGGCCACTGGGGAGGGGGAAGGGAATCATTTTGTGTTC ATTTTTGTTTTCTGTTTCACCTAAACCAGCATAGGATTGATAGGGGAGACGGTTGGCGGGCATTTCCGTTTCTATGTGACCAAGGCAGCA GGGGCTTTTACCTGCTAAGCGGCAATCCTTTGGCCCTGAGAATTTGGGAGAGAACAGTGCATCAGGCCAGGCTCAGCAATATGTTTGCTC ACATTCTTTCAGCCTTCTGTCACCCCCCTCAACACCAAACTTTCTTCCTTGTGAGCAGAAGGTTGGCTGCTGTTAGCAGGATCCCACAGT GATAACCAGGCCCTTCCCTTCCTAAGCCAAAACCCATTGTGACTGCCTGTCTCTCCTGTCTCTGACTTCTCAGGCAGCCTCCTGAGTGCA CTGAGTTGTATCCGAGAGGGTGGGAACAGCAGCATCCCCTAATTGCAGTACACGGTTCCTTTTCCGCCCGCCACCCTGCCTTTCCTTGGG GGCAGCTGTCTCTCTGTACATGAGCAAATGGGCAAAAACAGTCCCCAAACCCAGCACCCCCCTCTCCCTGGCTGCAGCCCACACTGTAAC ATCCCTAGTGAGGCTCCAGCCTAATGAGCCCCTTATTTTCTTTTTTTTCCCTCCCCAGGTCTAGTAGCTCTAACTAAAAAGTTCTTGGAG CCATCGTGCTCCCCCTTTGTTATTTTTCTTGCTATCAGAGTAGCAAGAAACAGCACCCCTGTAGGTGACAGGTGGGCAGCCTGGTAGGGG TCGCCAGCCTCCATGCCCCCTCATCTTCCAGTTCTTGCTTAGTGGCACGACCTCTTTCCATAGCATAAATGCAGGCCAGCGTTTTAGCCC CAAGTGCCTGCCCTTGCTTCTTACCCCTCCCCTGCTTTCTCAAACACTTGCCCACCTCAGGCACTCAGCGGGCTCCGCCGTGGTGAGAGA ACTGGCCGTGGCTCAGCCCCGGGTAGCACCTGTAGTTTCAGTGCCACTCTCCACTGTCCCCTTGTGGACCAGCTTCCACTCACTGTCACG TCCCCCCTCCTGCGTCTTCACTGGGTCTCAGGCTGCCAGCAGCTCTCTGGTGCATCGTCTCAACACCACCAAGTTTGTAGGACCTGCCCA AGTTCTAGTAGTATTCAAAACTTCAAACGGCAGTCATTTGTTCTCCTCGGCTCTGTGGCAAGGATAGCCCTTTGGAGGGGGACTCTTGAC CTCGGCTGTTAGGGATCTGAACTTGGTTTTCCCGTCAGAAGAATCAGCAGGACAGATCGTAGTGCCTTATTCCATTGTCCTCCCCTGGCC AGGCCTCCTGGCTCAGCTGGAAGTGCATGGCTTCTTTCTCCCTATCTGTGTCCTCTGTCACTTGCTCTTTCACTCTCTCTCTCATTCCCA GAGAGCCACGGGGGAGGGATCACCCTCACCCCCAACACCCTCTTCCTGAGGGCTGTAGCCAGGTCCGCATCTCCCCACCACCACCAGGGC ACTCACTCGCAGCTATAGCCCAGGACAGAAAAACTGTGCTTTGGACAGGTGCACACTCTCTGCCTCTTACCTCTAGCCAGGAGGATGCCT CAGTCTGTTCATTCGAGACTGGCCCCGTCTGAACCTTCTCTGGGCACTGGGGACTAAGGTTGCAGGCCTTAGCCTCGTCTCGTCCCAGAG GCATTGGATCAGGAGAATGGGAATTTTTTTCCTCCCACCTGGACATAGTTTGCCCCTGTGGCTGCCTTTCTGAGGGAGTATACTAAATGT TTACTTAAGAAACACCCTGTTTACAGCCAGAGGAGAAACACCCAACACTGAGTGGAGATTTGACTCTGGACAGGGCCTGGCCTCCTTAGT GGCACTGCCGGGGGGCCCCAGAGCGAATGAGGGCAGAGATGCCCGGGGCAGGGGCAAACGCCCTCCGCTCCCTCTGCTCCCAACCCTGTG GTGCTAGGACCACTCCCCGCCTTCCCTACGGCCTCCTCGCCCTGCACATTCCCCACCTCCACATTCCCCTCCTCCAAGATCTCAGCTCCT TAACATATCAGTTGTCTCCTAGCCTAGAAAACCAGTGTTTGGAGCAATAAGATGATTATTTTTGCTTGAATCTTTTTCTAAGAGAAGGAA AAGAGCTGGCATTGTGGGAATTTTCTTTTTATGCTGTTAGCTGTTTACCTTCTTAGAAGACATCCTAATAGGATGGATGTCTGGGTTTTA GCCTTGGGGTATCTTTTGGAAACTTAGAAAAGCAGGAGTCAGGCTGCCACCCCCTAAGGAGGGACCCTAACGTTCTGCCCTTGCCTGGTT CCATATGGCTCCTTCCAGCCCTGCCCACCAAGTGCAGCTCCCACTTTCCATCCTGCCCATACGCCCCTCTTCCCCCGACATCTGGGGGCG CTGGTGGCACTTACTCTAGGTTGGTCTCAGACTATCCCTCCCCTTGGCTGGTTTTCCCTCCTAGGCCTGTCTGGCAGCCCCCAGACAGAC GTAGCTCCTGGGAGTCTCGGCCCTGGCAACCTTGGAAGAGCCAAGCTGACATTGTTTAGCTCTTCAGGCCACTGGGTTTTGGAGGCAGAA GTCCAGAGATACTGGCTCTGCCAAGCTGTCGTACTGGGCTGTGGCACAGCCTTCGAGACAACACGGGTGTATCTCTGATCCTGCCCTACC TAGGCTTCAAGGGGCTTCTGTCTGGAGAAATGCCCTCAAAGGGTAACCAGTAGGTGTGGCATTGAATTGGCCAGTGTTAGCATCTACAGC CATCACCGAGATGAGTCCACTGCCGTTGCCTGCCCGAGGGCCCCCTAAGGTTATAGACGGTATCAGCAGGGAGGCCGTCCCGCTGGTTTT CTAGGAGAGCCCACAGGAGGAAGGGAGCCTCTTCAGGGGCACTGGAATCTTTTGTGCCAGGGGCTTCTTTTCATCAGAGCCGGGGAGTAC ATTGCAGTGACTTCTTAAACATTTGTGTGGGACAGACGAGCGTGAGGGAGGTTTTAAGCCAGGCACAAAGTTAGTTTCCAATACTAGTTA ATAAATCTATTTTTCTTCATTTCCTTTTTTTGCACAGAAGCTGGTAATCTAGGACCTACGTGTGAACAACTTTATATGAATATTTTTTGT ACTTGGTTTACTTGGGTTGGTATGATACATTATATTTAAGTTCCTTGAACACTGTGGATCCCCTAATGTGTATGAATGACTGAGGCTTTG >71363_71363_2_RAB3GAP1-STK35_RAB3GAP1_chr2_135815656_ENST00000442034_STK35_chr20_2083414_ENST00000381482_length(amino acids)=486AA_BP=40 MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSLGKPLEKVTIQGPAPPRPRAGRRDEAGGARAAPLLLPPPPAAMETGK DGARRGTQSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARV AVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFC EGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVN KYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSM -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RAB3GAP1-STK35 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RAB3GAP1-STK35 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RAB3GAP1-STK35 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RAB3GAP1 | C1838625 | Warburg Sjo Fledelius syndrome | 5 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
Hgene | RAB3GAP1 | C0796037 | Martsolf syndrome | 1 | ORPHANET |