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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:FOXO1-PAX3 (FusionGDB2 ID:HG2308TG5077)

Fusion Gene Summary for FOXO1-PAX3

check button Fusion gene summary
Fusion gene informationFusion gene name: FOXO1-PAX3
Fusion gene ID: hg2308tg5077
HgeneTgene
Gene symbol

FOXO1

PAX3

Gene ID

2308

5077

Gene nameforkhead box O1paired box 3
SynonymsFKH1|FKHR|FOXO1ACDHS|HUP2|WS1|WS3
Cytomap('FOXO1')('PAX3')

13q14.11

2q36.1

Type of geneprotein-codingprotein-coding
Descriptionforkhead box protein O1forkhead box protein O1Aforkhead, Drosophila, homolog of, in rhabdomyosarcomapaired box protein Pax-3paired box homeotic gene 3paired domain gene 3paired domain gene HuP2transcriptional factor PAX3
Modification date2020032220200313
UniProtAcc

Q12778

P23760

Ensembl transtripts involved in fusion geneENST00000379561, ENST00000473775, 
ENST00000473775, ENST00000379561, 
Fusion gene scores* DoF score13 X 12 X 9=14048 X 11 X 3=264
# samples 169
** MAII scorelog2(16/1404*10)=-3.1333991254172
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/264*10)=-1.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FOXO1 [Title/Abstract] AND PAX3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFOXO1(41239718)-PAX3(223066911), # samples:3
Anticipated loss of major functional domain due to fusion event.FOXO1-PAX3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXO1-PAX3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXO1-PAX3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXO1-PAX3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PAX3-FOXO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PAX3-FOXO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFOXO1

GO:0009267

cellular response to starvation

20543840

HgeneFOXO1

GO:0032873

negative regulation of stress-activated MAPK cascade

19696738

HgeneFOXO1

GO:0043066

negative regulation of apoptotic process

10871843

HgeneFOXO1

GO:0045893

positive regulation of transcription, DNA-templated

7862145|10871843|12228231

HgeneFOXO1

GO:0045944

positive regulation of transcription by RNA polymerase II

10871843|12228231

HgeneFOXO1

GO:0071455

cellular response to hyperoxia

20543840

TgenePAX3

GO:0045893

positive regulation of transcription, DNA-templated

11863357

TgenePAX3

GO:0045944

positive regulation of transcription by RNA polymerase II

11863357


check buttonFusion gene breakpoints across FOXO1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PAX3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4rhabdomyosarcomaJX141474FOXO1chr13

41240779

PAX3chr2

223066552
ChimerKB3..FOXO1chr13

41132547

-PAX3chr2

223163383

-
ChimerKB3..FOXO1chr13

41134997

-PAX3chr2

223084858

-
ChimerKB4..FOXO1chr13

41134997

-PAX3chr2

223084858

-
ChiTaRS5.0N/AJX141474FOXO1chr13

41239718

-PAX3chr2

223066911

-
ChiTaRS5.0N/AJX141475FOXO1chr13

41239718

-PAX3chr2

223066911

-
ChiTaRS5.0N/AJX141476FOXO1chr13

41239718

-PAX3chr2

223066911

-


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Fusion Gene ORF analysis for FOXO1-PAX3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000379561ENST00000464706FOXO1chr13

41239718

-PAX3chr2

223066911

-
5CDS-intronENST00000379561ENST00000258387FOXO1chr13

41239718

-PAX3chr2

223066911

-
5CDS-intronENST00000379561ENST00000336840FOXO1chr13

41239718

-PAX3chr2

223066911

-
5CDS-intronENST00000379561ENST00000344493FOXO1chr13

41239718

-PAX3chr2

223066911

-
5CDS-intronENST00000379561ENST00000350526FOXO1chr13

41239718

-PAX3chr2

223066911

-
5CDS-intronENST00000379561ENST00000392070FOXO1chr13

41239718

-PAX3chr2

223066911

-
5CDS-intronENST00000379561ENST00000409551FOXO1chr13

41239718

-PAX3chr2

223066911

-
5CDS-intronENST00000379561ENST00000409828FOXO1chr13

41239718

-PAX3chr2

223066911

-
In-frameENST00000379561ENST00000392069FOXO1chr13

41239718

-PAX3chr2

223066911

-
intron-3CDSENST00000473775ENST00000392069FOXO1chr13

41239718

-PAX3chr2

223066911

-
intron-3UTRENST00000379561ENST00000350526FOXO1chr13

41240779

PAX3chr2

223066552

intron-3UTRENST00000473775ENST00000350526FOXO1chr13

41240779

PAX3chr2

223066552

intron-5UTRENST00000379561ENST00000258387FOXO1chr13

41132547

-PAX3chr2

223163383

-
intron-5UTRENST00000379561ENST00000336840FOXO1chr13

41132547

-PAX3chr2

223163383

-
intron-5UTRENST00000379561ENST00000344493FOXO1chr13

41132547

-PAX3chr2

223163383

-
intron-5UTRENST00000379561ENST00000350526FOXO1chr13

41132547

-PAX3chr2

223163383

-
intron-5UTRENST00000379561ENST00000392069FOXO1chr13

41132547

-PAX3chr2

223163383

-
intron-5UTRENST00000379561ENST00000392070FOXO1chr13

41132547

-PAX3chr2

223163383

-
intron-5UTRENST00000379561ENST00000409551FOXO1chr13

41132547

-PAX3chr2

223163383

-
intron-5UTRENST00000379561ENST00000409828FOXO1chr13

41132547

-PAX3chr2

223163383

-
intron-5UTRENST00000473775ENST00000258387FOXO1chr13

41132547

-PAX3chr2

223163383

-
intron-5UTRENST00000473775ENST00000336840FOXO1chr13

41132547

-PAX3chr2

223163383

-
intron-5UTRENST00000473775ENST00000344493FOXO1chr13

41132547

-PAX3chr2

223163383

-
intron-5UTRENST00000473775ENST00000350526FOXO1chr13

41132547

-PAX3chr2

223163383

-
intron-5UTRENST00000473775ENST00000392069FOXO1chr13

41132547

-PAX3chr2

223163383

-
intron-5UTRENST00000473775ENST00000392070FOXO1chr13

41132547

-PAX3chr2

223163383

-
intron-5UTRENST00000473775ENST00000409551FOXO1chr13

41132547

-PAX3chr2

223163383

-
intron-5UTRENST00000473775ENST00000409828FOXO1chr13

41132547

-PAX3chr2

223163383

-
intron-5UTRENST00000473775ENST00000464706FOXO1chr13

41239718

-PAX3chr2

223066911

-
intron-intronENST00000379561ENST00000258387FOXO1chr13

41240779

PAX3chr2

223066552

intron-intronENST00000379561ENST00000258387FOXO1chr13

41134997

-PAX3chr2

223084858

-
intron-intronENST00000379561ENST00000336840FOXO1chr13

41240779

PAX3chr2

223066552

intron-intronENST00000379561ENST00000336840FOXO1chr13

41134997

-PAX3chr2

223084858

-
intron-intronENST00000379561ENST00000344493FOXO1chr13

41240779

PAX3chr2

223066552

intron-intronENST00000379561ENST00000344493FOXO1chr13

41134997

-PAX3chr2

223084858

-
intron-intronENST00000379561ENST00000350526FOXO1chr13

41134997

-PAX3chr2

223084858

-
intron-intronENST00000379561ENST00000392069FOXO1chr13

41240779

PAX3chr2

223066552

intron-intronENST00000379561ENST00000392069FOXO1chr13

41134997

-PAX3chr2

223084858

-
intron-intronENST00000379561ENST00000392070FOXO1chr13

41240779

PAX3chr2

223066552

intron-intronENST00000379561ENST00000392070FOXO1chr13

41134997

-PAX3chr2

223084858

-
intron-intronENST00000379561ENST00000409551FOXO1chr13

41240779

PAX3chr2

223066552

intron-intronENST00000379561ENST00000409551FOXO1chr13

41134997

-PAX3chr2

223084858

-
intron-intronENST00000379561ENST00000409828FOXO1chr13

41240779

PAX3chr2

223066552

intron-intronENST00000379561ENST00000409828FOXO1chr13

41134997

-PAX3chr2

223084858

-
intron-intronENST00000379561ENST00000464706FOXO1chr13

41240779

PAX3chr2

223066552

intron-intronENST00000379561ENST00000464706FOXO1chr13

41132547

-PAX3chr2

223163383

-
intron-intronENST00000379561ENST00000464706FOXO1chr13

41134997

-PAX3chr2

223084858

-
intron-intronENST00000473775ENST00000258387FOXO1chr13

41240779

PAX3chr2

223066552

intron-intronENST00000473775ENST00000258387FOXO1chr13

41134997

-PAX3chr2

223084858

-
intron-intronENST00000473775ENST00000258387FOXO1chr13

41239718

-PAX3chr2

223066911

-
intron-intronENST00000473775ENST00000336840FOXO1chr13

41240779

PAX3chr2

223066552

intron-intronENST00000473775ENST00000336840FOXO1chr13

41134997

-PAX3chr2

223084858

-
intron-intronENST00000473775ENST00000336840FOXO1chr13

41239718

-PAX3chr2

223066911

-
intron-intronENST00000473775ENST00000344493FOXO1chr13

41240779

PAX3chr2

223066552

intron-intronENST00000473775ENST00000344493FOXO1chr13

41134997

-PAX3chr2

223084858

-
intron-intronENST00000473775ENST00000344493FOXO1chr13

41239718

-PAX3chr2

223066911

-
intron-intronENST00000473775ENST00000350526FOXO1chr13

41134997

-PAX3chr2

223084858

-
intron-intronENST00000473775ENST00000350526FOXO1chr13

41239718

-PAX3chr2

223066911

-
intron-intronENST00000473775ENST00000392069FOXO1chr13

41240779

PAX3chr2

223066552

intron-intronENST00000473775ENST00000392069FOXO1chr13

41134997

-PAX3chr2

223084858

-
intron-intronENST00000473775ENST00000392070FOXO1chr13

41240779

PAX3chr2

223066552

intron-intronENST00000473775ENST00000392070FOXO1chr13

41134997

-PAX3chr2

223084858

-
intron-intronENST00000473775ENST00000392070FOXO1chr13

41239718

-PAX3chr2

223066911

-
intron-intronENST00000473775ENST00000409551FOXO1chr13

41240779

PAX3chr2

223066552

intron-intronENST00000473775ENST00000409551FOXO1chr13

41134997

-PAX3chr2

223084858

-
intron-intronENST00000473775ENST00000409551FOXO1chr13

41239718

-PAX3chr2

223066911

-
intron-intronENST00000473775ENST00000409828FOXO1chr13

41240779

PAX3chr2

223066552

intron-intronENST00000473775ENST00000409828FOXO1chr13

41134997

-PAX3chr2

223084858

-
intron-intronENST00000473775ENST00000409828FOXO1chr13

41239718

-PAX3chr2

223066911

-
intron-intronENST00000473775ENST00000464706FOXO1chr13

41240779

PAX3chr2

223066552

intron-intronENST00000473775ENST00000464706FOXO1chr13

41132547

-PAX3chr2

223163383

-
intron-intronENST00000473775ENST00000464706FOXO1chr13

41134997

-PAX3chr2

223084858

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379561FOXO1chr1341239718-ENST00000392069PAX3chr2223066911-26461015431359438

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379561ENST00000392069FOXO1chr1341239718-PAX3chr2223066911-0.0046214980.9953785

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Fusion Genomic Features for FOXO1-PAX3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FOXO1-PAX3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:41239718/chr2:223066911)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FOXO1

Q12778

PAX3

P23760

FUNCTION: Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}.FUNCTION: Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (PubMed:21965087). {ECO:0000269|PubMed:16951170, ECO:0000269|PubMed:21965087}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOXO1chr13:41239718chr2:223066911ENST00000379561-13120_1302101440.3333333333333Compositional biasNote=Poly-Pro
HgeneFOXO1chr13:41239718chr2:223066911ENST00000379561-13152_1552101440.3333333333333Compositional biasNote=Poly-Ser
HgeneFOXO1chr13:41239718chr2:223066911ENST00000379561-1391_1022101440.3333333333333Compositional biasNote=Poly-Ala
TgenePAX3chr13:41239718chr2:223066911ENST0000025838705219_2780207.0DNA bindingHomeobox
TgenePAX3chr13:41239718chr2:223066911ENST000002583870534_1610207.0DNA bindingPaired
TgenePAX3chr13:41239718chr2:223066911ENST0000033684009219_2780408.0DNA bindingHomeobox
TgenePAX3chr13:41239718chr2:223066911ENST000003368400934_1610408.0DNA bindingPaired
TgenePAX3chr13:41239718chr2:223066911ENST0000034449308219_2780404.0DNA bindingHomeobox
TgenePAX3chr13:41239718chr2:223066911ENST000003444930834_1610404.0DNA bindingPaired
TgenePAX3chr13:41239718chr2:223066911ENST0000040982804219_2780216.0DNA bindingHomeobox
TgenePAX3chr13:41239718chr2:223066911ENST000004098280434_1610216.0DNA bindingPaired
TgenePAX3chr13:41239718chr2:223066911ENST0000025838705113_1610207.0RegionRED subdomain
TgenePAX3chr13:41239718chr2:223066911ENST000002583870537_930207.0RegionPAI subdomain
TgenePAX3chr13:41239718chr2:223066911ENST0000033684009113_1610408.0RegionRED subdomain
TgenePAX3chr13:41239718chr2:223066911ENST000003368400937_930408.0RegionPAI subdomain
TgenePAX3chr13:41239718chr2:223066911ENST0000034449308113_1610404.0RegionRED subdomain
TgenePAX3chr13:41239718chr2:223066911ENST000003444930837_930404.0RegionPAI subdomain
TgenePAX3chr13:41239718chr2:223066911ENST0000040982804113_1610216.0RegionRED subdomain
TgenePAX3chr13:41239718chr2:223066911ENST000004098280437_930216.0RegionPAI subdomain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOXO1chr13:41239718chr2:223066911ENST00000379561-13159_2352101440.3333333333333DNA bindingFork-head
HgeneFOXO1chr13:41239718chr2:223066911ENST00000379561-13211_2182101440.3333333333333RegionNote=DNA-binding
HgeneFOXO1chr13:41239718chr2:223066911ENST00000379561-13234_2372101440.3333333333333RegionNote=DNA-binding
TgenePAX3chr13:41239718chr2:223066911ENST0000035052668219_278391480.0DNA bindingHomeobox
TgenePAX3chr13:41239718chr2:223066911ENST000003505266834_161391480.0DNA bindingPaired
TgenePAX3chr13:41239718chr2:223066911ENST00000392069610219_278391506.0DNA bindingHomeobox
TgenePAX3chr13:41239718chr2:223066911ENST0000039206961034_161391506.0DNA bindingPaired
TgenePAX3chr13:41239718chr2:223066911ENST0000039207069219_278391485.0DNA bindingHomeobox
TgenePAX3chr13:41239718chr2:223066911ENST000003920706934_161391485.0DNA bindingPaired
TgenePAX3chr13:41239718chr2:223066911ENST0000040955169219_278390484.0DNA bindingHomeobox
TgenePAX3chr13:41239718chr2:223066911ENST000004095516934_161390484.0DNA bindingPaired
TgenePAX3chr13:41239718chr2:223066911ENST0000035052668113_161391480.0RegionRED subdomain
TgenePAX3chr13:41239718chr2:223066911ENST000003505266837_93391480.0RegionPAI subdomain
TgenePAX3chr13:41239718chr2:223066911ENST00000392069610113_161391506.0RegionRED subdomain
TgenePAX3chr13:41239718chr2:223066911ENST0000039206961037_93391506.0RegionPAI subdomain
TgenePAX3chr13:41239718chr2:223066911ENST0000039207069113_161391485.0RegionRED subdomain
TgenePAX3chr13:41239718chr2:223066911ENST000003920706937_93391485.0RegionPAI subdomain
TgenePAX3chr13:41239718chr2:223066911ENST0000040955169113_161390484.0RegionRED subdomain
TgenePAX3chr13:41239718chr2:223066911ENST000004095516937_93390484.0RegionPAI subdomain


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Fusion Gene Sequence for FOXO1-PAX3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31165_31165_1_FOXO1-PAX3_FOXO1_chr13_41239718_ENST00000379561_PAX3_chr2_223066911_ENST00000392069_length(transcript)=2646nt_BP=1015nt
GCAGCCGCCACATTCAACAGGCAGCAGCGCAGCGGGCGCGCCGCTGGGGAGAGCAAGCGGCCCGCGGCGTCCGTCCGTCCTTCCGTCCGC
GGCCCTGTCAGCTGGAGCGCGGCGCAGGCTCTGCCCCGGCCCGGCGGCTCTGGCCGGCCGTCCAGTCCGTGCGGCGGACCCCGAGGAGCC
TCGATGTGGATGGCCCCGCGAAGTTAAGTTCTGGGCTCGCGCTTCCACTCCGCCGCGCCTTCCTCCCAGTTTCCGTCCGCTCGCCGCACC
GGCTTCGTTCCCCCAAATCTCGGACCGTCCCTTCGCGCCCCCTCCCCGTCCGCCCCCAGTGCTGCGTTCTCCCCCTCTTGGCTCTCCTGC
GGCTGGGGGAGGGGCGGGGGTCACCATGGCCGAGGCGCCTCAGGTGGTGGAGATCGACCCGGACTTCGAGCCGCTGCCCCGGCCGCGCTC
GTGCACCTGGCCGCTGCCCAGGCCGGAGTTTAGCCAGTCCAACTCGGCCACCTCCAGCCCGGCGCCGTCGGGCAGCGCGGCTGCCAACCC
CGACGCCGCGGCGGGCCTGCCCTCGGCCTCGGCTGCCGCTGTCAGCGCCGACTTCATGAGCAACCTGAGCTTGCTGGAGGAGAGCGAGGA
CTTCCCGCAGGCGCCCGGCTCCGTGGCGGCGGCGGTGGCGGCGGCGGCCGCCGCGGCCGCCACCGGGGGGCTGTGCGGGGACTTCCAGGG
CCCGGAGGCGGGCTGCCTGCACCCAGCGCCACCGCAGCCCCCGCCGCCCGGGCCGCTGTCGCAGCACCCGCCGGTGCCCCCCGCCGCCGC
TGGGCCGCTCGCGGGGCAGCCGCGCAAGAGCAGCTCGTCCCGCCGCAACGCGTGGGGCAACCTGTCCTACGCCGACCTCATCACCAAGGC
CATCGAGAGCTCGGCGGAGAAGCGGCTCACGCTGTCGCAGATCTACGAGTGGATGGTCAAGAGCGTGCCCTACTTCAAGGATAAGGGTGA
CAGCAACAGCTCGGCGGGCTGGAAGGTAATGGGACTCCTGACCAACCACGGTGGGGTACCTCATCAGCCCCAGACTGATTACGCGCTCTC
CCCTCTCACCGGGGGTCTGGAACCTACCACCACGGTGTCGGCCAGCTGCAGTCAGAGACTAGACCATATGAAGAGCTTGGACAGTCTGCC
AACATCTCAGTCCTACTGTCCACCCACCTATAGCACCACAGGCTACAGTATGGACCCTGTCACAGGCTACCAATATGGGCAGTATGGACA
AAGTGCCTTTCATTATCTCAAGCCAGATATCGCTTGGTTTCAAATCCTTTTGAACACGTTCGACAAAAGCAGTGGAGAAGAGGAAGACCT
GGAGCAATAAAAGACAAATGCAACATTTTAAGGCAATGGTTTCACATGGTTACATATCAAAACATCCCAATTCTTTAGTGCTGATCATCG
AGGAGCTAGAACATTCCATTTGCTTGTGTGCGTGCGTGCGTGTGTGTGTGTGTGTGTGTATTGAGATTTACCCAGACTGGTTTGGGCAAG
CAGACTGTTCTAAAATATAATAGAATACCCTAAAGTATAACATGTCGATGTTCGATGCTGATACTTCTACAACTTTAAAACTGCTCATTT
CATGAAGCAAGAATGGAGGAATCCTTGACTCTTACACACTGGAAATTGAAATAAAGATAAATGCAACCATTTTTAGGAAGCTAGACTAGC
TGTAAAGGACCTCCTAAATAAATTATTTGTTACTGTATCCTCATTTGTAATCTAGTTGTCAATAAATGGCCCGGACATGTCTTGCTAACA
GGATATGGGCTACCAGGAAGAAGGACTTGTTTCCCTTTCCTGTGTGGGGAGAGGTGTGTGACGTTTTTCCAGTTCACATTTATTTGGTAG
CCCACCTGGGTTGGAGGAAGGGCACGGTGGAGAGAAAGTGACATGCATTCACATATCTGCTTATCAGTGTGCAATACTGTGTACCTCATG
GATGCTTTGGCAATGCCCAAGGCGATATAAGCAAAATCAGAAGTATATTTTTGCAGGTGCTTTTATTTTCACAGCCCATAATTCATAGTG
ATAGAGTGCAGTGATGTTTGCCATTTGCTGGACAACCAACACCCGGGTTGCTCCTTTGATTAGAGACCAGATCAGATAATTATGCTTTTA
AACTGATTACGTTTACATTCTTCTCTTTTCTATGAAAGGCAGGGCAAGAACAGAAGTGTTCACATGGCTCTCATGTACTTTTAAATTATA
CAATGATATCCAATATTAAAAGATTATAGGAACTGAGGTTTACATACGTTTGTGTGGTGACATTTTAGAATGTCAATAAATTTGCTTTTT
GAGATGTTGAGAGGAACAAGAAGGTGGAAGGCAGTGTTATTTATTTCTTTCTATTCTTGGAACCACGAATGAGGTAGGCACAAATACATT
CCTTTTAGAGTTAAGAACTATGACGTAGCGAGTTAGTGAGACTAGACATAGTACCGAATTTAGTTCATGCATTGGTCTTAGAGGGTGATG
GAACAAGAGAAGTACTATCTTTGTGTTGCAGCCTCAACCAACAACAATGTGTTGTAAAAATGTCTTTCATGTAAAAAGTGCAGTAAATAT

>31165_31165_1_FOXO1-PAX3_FOXO1_chr13_41239718_ENST00000379561_PAX3_chr2_223066911_ENST00000392069_length(amino acids)=438AA_BP=324
MGRASGPRRPSVLPSAALSAGARRRLCPGPAALAGRPVRAADPEEPRCGWPREVKFWARASTPPRLPPSFRPLAAPASFPQISDRPFAPP
PRPPPVLRSPPLGSPAAGGGAGVTMAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEFSQSNSATSSPAPSGSAAANPDAAAGLPSASAAAV
SADFMSNLSLLEESEDFPQAPGSVAAAVAAAAAAAATGGLCGDFQGPEAGCLHPAPPQPPPPGPLSQHPPVPPAAAGPLAGQPRKSSSSR
RNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKVMGLLTNHGGVPHQPQTDYALSPLTGGLEPTTTVSA

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Fusion Gene PPI Analysis for FOXO1-PAX3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FOXO1-PAX3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FOXO1-PAX3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFOXO1C0020542Pulmonary Hypertension1CTD_human
HgeneFOXO1C0022578Keratoconus1CTD_human
HgeneFOXO1C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneFOXO1C0026998Acute Myeloid Leukemia, M11CTD_human
HgeneFOXO1C0033578Prostatic Neoplasms1CTD_human
HgeneFOXO1C0206655Alveolar rhabdomyosarcoma1CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneFOXO1C0376358Malignant neoplasm of prostate1CTD_human
HgeneFOXO1C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneC1847800Waardenburg Syndrome Type 133CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0079661Klein's Syndrome16CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC3266898Waardenburg Syndrome12CLINGEN;CTD_human;GENOMICS_ENGLAND
TgeneC1852510Craniofacial deafness hand syndrome5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0038219Status Dysraphicus4CTD_human
TgeneC0080178Spina Bifida4CTD_human
TgeneC0266508Rachischisis4CTD_human
TgeneC0011999Diastematomyelia3CTD_human
TgeneC0027794Neural Tube Defects3CTD_human
TgeneC0027806Neurenteric Cyst3CTD_human
TgeneC0080218Tethered Cord Syndrome3CTD_human
TgeneC0152234Iniencephaly3CTD_human
TgeneC0152426Craniorachischisis3CTD_human
TgeneC0266453Exencephaly3CTD_human
TgeneC0344479Spinal Cord Myelodysplasia3CTD_human
TgeneC0599973Waardenburg Anophthalmia Syndrome3ORPHANET
TgeneC0702169Acrania3CTD_human
TgeneC0206655Alveolar rhabdomyosarcoma2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0011052Prelingual Deafness1CTD_human
TgeneC0011053Deafness1CTD_human
TgeneC0018566Congenital Hand Deformities1CTD_human
TgeneC0086395Hearing Loss, Extreme1CTD_human
TgeneC0205944Sarcoma, Epithelioid1CTD_human
TgeneC0205945Sarcoma, Spindle Cell1CTD_human
TgeneC0265541Cranioschisis1CTD_human
TgeneC0376634Craniofacial Abnormalities1CTD_human
TgeneC0497552Congenital neurologic anomalies1CTD_human
TgeneC0581883Complete Hearing Loss1CTD_human
TgeneC0751068Deafness, Acquired1CTD_human
TgeneC1261473Sarcoma1CTD_human
TgeneC1710096Sinonasal undifferentiated carcinoma1CTD_human
TgeneC3665473Bilateral Deafness1CTD_human
TgeneC4082305Deaf Mutism1CTD_human