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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLEKHM2-CENPI (FusionGDB2 ID:HG23207TG2491)

Fusion Gene Summary for PLEKHM2-CENPI

check button Fusion gene summary
Fusion gene informationFusion gene name: PLEKHM2-CENPI
Fusion gene ID: hg23207tg2491
HgeneTgene
Gene symbol

PLEKHM2

CENPI

Gene ID

23207

2491

Gene namepleckstrin homology and RUN domain containing M2centromere protein I
SynonymsSKIPCENP-I|FSHPRH1|LRPR1
Cytomap('PLEKHM2')('CENPI')

1p36.21

Xq22.1

Type of geneprotein-codingprotein-coding
Descriptionpleckstrin homology domain-containing family M member 2PH domain-containing family M member 2SifA (Salmonella-induced filaments A) and kinesin-interacting proteinnovel RUN and PH domain-containing proteinpleckstrin homology domain containing, family Mcentromere protein IFSH primary response 1follicle-stimulating hormone primary response proteininterphase centromere complex protein 19leucine-rich primary response protein 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000375793, ENST00000375799, 
ENST00000477849, 
Fusion gene scores* DoF score9 X 7 X 6=3781 X 1 X 1=1
# samples 91
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: PLEKHM2 [Title/Abstract] AND CENPI [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLEKHM2(16011113)-CENPI(100395655), # samples:1
Anticipated loss of major functional domain due to fusion event.PLEKHM2-CENPI seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PLEKHM2-CENPI seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PLEKHM2-CENPI seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PLEKHM2-CENPI seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLEKHM2

GO:1903527

positive regulation of membrane tubulation

18996344


check buttonFusion gene breakpoints across PLEKHM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CENPI (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0RT-01APLEKHM2chr1

16011113

+CENPIchrX

100395655

+


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Fusion Gene ORF analysis for PLEKHM2-CENPI

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000375793ENST00000372926PLEKHM2chr1

16011113

+CENPIchrX

100395655

+
Frame-shiftENST00000375799ENST00000372926PLEKHM2chr1

16011113

+CENPIchrX

100395655

+
In-frameENST00000375793ENST00000218507PLEKHM2chr1

16011113

+CENPIchrX

100395655

+
In-frameENST00000375793ENST00000372927PLEKHM2chr1

16011113

+CENPIchrX

100395655

+
In-frameENST00000375793ENST00000423383PLEKHM2chr1

16011113

+CENPIchrX

100395655

+
In-frameENST00000375799ENST00000218507PLEKHM2chr1

16011113

+CENPIchrX

100395655

+
In-frameENST00000375799ENST00000372927PLEKHM2chr1

16011113

+CENPIchrX

100395655

+
In-frameENST00000375799ENST00000423383PLEKHM2chr1

16011113

+CENPIchrX

100395655

+
intron-3CDSENST00000477849ENST00000218507PLEKHM2chr1

16011113

+CENPIchrX

100395655

+
intron-3CDSENST00000477849ENST00000372926PLEKHM2chr1

16011113

+CENPIchrX

100395655

+
intron-3CDSENST00000477849ENST00000372927PLEKHM2chr1

16011113

+CENPIchrX

100395655

+
intron-3CDSENST00000477849ENST00000423383PLEKHM2chr1

16011113

+CENPIchrX

100395655

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375799PLEKHM2chr116011113+ENST00000218507CENPIchrX100395655+15152871371045302
ENST00000375799PLEKHM2chr116011113+ENST00000423383CENPIchrX100395655+15572871371087316
ENST00000375799PLEKHM2chr116011113+ENST00000372927CENPIchrX100395655+18022871371087316
ENST00000375793PLEKHM2chr116011113+ENST00000218507CENPIchrX100395655+145722979987302
ENST00000375793PLEKHM2chr116011113+ENST00000423383CENPIchrX100395655+1499229791029316
ENST00000375793PLEKHM2chr116011113+ENST00000372927CENPIchrX100395655+1744229791029316

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375799ENST00000218507PLEKHM2chr116011113+CENPIchrX100395655+0.010519980.98948
ENST00000375799ENST00000423383PLEKHM2chr116011113+CENPIchrX100395655+0.0056684880.9943315
ENST00000375799ENST00000372927PLEKHM2chr116011113+CENPIchrX100395655+0.0038382210.9961618
ENST00000375793ENST00000218507PLEKHM2chr116011113+CENPIchrX100395655+0.0107517190.98924834
ENST00000375793ENST00000423383PLEKHM2chr116011113+CENPIchrX100395655+0.0060342890.9939657
ENST00000375793ENST00000372927PLEKHM2chr116011113+CENPIchrX100395655+0.0040223750.9959777

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Fusion Genomic Features for PLEKHM2-CENPI


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PLEKHM2chr116011113+CENPIchrX100395654+4.29E-091
PLEKHM2chr116011113+CENPIchrX100395654+4.29E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PLEKHM2-CENPI


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:16011113/chrX:100395655)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHM2chr1:16011113chrX:100395655ENST00000375799+120317_320201020.0Compositional biasNote=Poly-Lys
HgenePLEKHM2chr1:16011113chrX:100395655ENST00000375799+120323_326201020.0Compositional biasNote=Poly-Lys
HgenePLEKHM2chr1:16011113chrX:100395655ENST00000375799+120506_511201020.0Compositional biasNote=Poly-Gly
HgenePLEKHM2chr1:16011113chrX:100395655ENST00000375799+120593_596201020.0Compositional biasNote=Poly-Leu
HgenePLEKHM2chr1:16011113chrX:100395655ENST00000375799+12036_158201020.0DomainRUN
HgenePLEKHM2chr1:16011113chrX:100395655ENST00000375799+120771_873201020.0DomainPH


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Fusion Gene Sequence for PLEKHM2-CENPI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66316_66316_1_PLEKHM2-CENPI_PLEKHM2_chr1_16011113_ENST00000375793_CENPI_chrX_100395655_ENST00000218507_length(transcript)=1457nt_BP=229nt
AGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGGGCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGC
CCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGGGCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGG
GGAGGTGAAGGACCGGATCCTGGAGAACATCTCGCTGTCGGTGAAGAAGTGTAGTGTGCTTCAGAGTCTGAAAGAGCTATTGCAGAATTG
GCTGTTGTGGCTTTCTATGGACATTCACATGAAACCTGTTACAAACAGTCCTCTAGAGACAACTTTGGGTGGATCCATGAACTCTGTGTC
TAAACTGATCCACTATGTAGGGTGGCTATCCACTACTGCAATGCGCTTGGAGAGCAACAATACTTTCTTGCTGCACTTTATTTTGGATTT
CTATGAGAAGGTGTGTGACATATATATAAATTATAACCTTCCATTAGTGGTATTGTTTCCTCCTGGGATCTTCTATTCTGCACTCCTCAG
CCTGGATACCAGCATCCTGAACCAGCTGTGTTTTATTATGCACAGATATCGTAAAAATTTGACTGCCGCAAAGAAAAATGAGTTGGTACA
AAAGACAAAATCAGAGTTCAATTTCAGCAGCAAGACTTATCAAGAATTTAATCACTATTTGACATCAATGGTTGGTTGCCTGTGGACGTC
CAAACCCTTTGGGAAAGGAATATATATTGACCCTGAAATCCTAGAAAAAACTGGAGTGGCTGAATATAAAAACAGTTTAAATGTAGTCCA
TCATCCTTCTTTCTTGAGTTACGCTGTTTCCTTTTTGCTACAGGGAAAGAAATGGAGCTGGTATTTGGACTATTTATTTTCACAGGGGTT
ACAAGGCTTGAAACTTTTTATAAGAAGTAGTGTTCATCATTCTTCCATTCCCAGAGCAGAGGGCATAAACTGCAACAATCAATATTAAAT
GAATGTTGACATAAACTGAACACACTGGACTAAACTCACTCCTCATTGCTAGAGCAAAGTGGCTCATCTTGAGTTCCCATTTTCATTTCA
CTGACAGACTGCCATCCTCAAGGAGTACTCAGACTGGCCTTCTGTTCATGGCTTAGGAGAGCCTTGGTGTGCCTAACTGATTTTTCAAAA
TTTAGATTTTTTTAGCCTACCAGTGAAAAATGACCCCTTCATCATCAGGCTCTGCGTTCTACCAAATTGTATGTAAAAAGACACATCTGT
TTTGTGGTAGGATTTTTTCACATTTTTGGGTACTATGAGCTGCATTGATGGAAGACAGCAGGCAATATGTGGTGACAGTTAACTCACAGA
CATAAACATGCAAAATACTTTGCTGTCTCTGGGGATATTGCCATTTTTCTTACTGTGAGCAACAGCACCAACACCAAGTTAACAGGATGC

>66316_66316_1_PLEKHM2-CENPI_PLEKHM2_chr1_16011113_ENST00000375793_CENPI_chrX_100395655_ENST00000218507_length(amino acids)=302AA_BP=43
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKCSVLQSLKELLQNWLLWLSMDIHMKPVTNSPLETTLGGSM
NSVSKLIHYVGWLSTTAMRLESNNTFLLHFILDFYEKVCDIYINYNLPLVVLFPPGIFYSALLSLDTSILNQLCFIMHRYRKNLTAAKKN
ELVQKTKSEFNFSSKTYQEFNHYLTSMVGCLWTSKPFGKGIYIDPEILEKTGVAEYKNSLNVVHHPSFLSYAVSFLLQGKKWSWYLDYLF

--------------------------------------------------------------
>66316_66316_2_PLEKHM2-CENPI_PLEKHM2_chr1_16011113_ENST00000375793_CENPI_chrX_100395655_ENST00000372927_length(transcript)=1744nt_BP=229nt
AGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGGGCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGC
CCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGGGCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGG
GGAGGTGAAGGACCGGATCCTGGAGAACATCTCGCTGTCGGTGAAGAAGTGTAGTGTGCTTCAGAGTCTGAAAGAGCTATTGCAGAATTG
GCTGTTGTGGCTTTCTATGGACATTCACATGAAACCTGTTACAAACAGTCCTCTAGAGACAACTTTGGGTGGATCCATGAACTCTGTGTC
TAAACTGATCCACTATGTAGGGTGGCTATCCACTACTGCAATGCGCTTGGAGAGCAACAATACTTTCTTGCTGCACTTTATTTTGGATTT
CTATGAGAAGGTGTGTGACATATATATAAATTATAACCTTCCATTAGTGGTATTGTTTCCTCCTGGGATCTTCTATTCTGCACTCCTCAG
CCTGGATACCAGCATCCTGAACCAGCTGTGTTTTATTATGCACAGATATCGTAAAAATTTGACTGCCGCAAAGAAAAATGAGTTGGTACA
AAAGACAAAATCAGAGTTCAATTTCAGCAGCAAGACTTATCAAGAATTTAATCACTATTTGACATCAATGGTTGGTTGCCTGTGGACGTC
CAAACCCTTTGGGAAAGGAATATATATTGACCCTGAAATCCTAGAAAAAACTGGAGTGGCTGAATATAAAAACAGTTTAAATGTAGTCCA
TCATCCTTCTTTCTTGAGTTACGCTGTTTCCTTTTTGCTACAGGAAAGCCCAGAAGAAAGGACAGTAAATGTGAGCTCTATTCGGGGAAA
GAAATGGAGCTGGTATTTGGACTATTTATTTTCACAGGGGTTACAAGGCTTGAAACTTTTTATAAGAAGTAGTGTTCATCATTCTTCCAT
TCCCAGAGCAGAGGGCATAAACTGCAACAATCAATATTAAATGAATGTTGACATAAACTGAACACACTGGACTAAACTCACTCCTCATTG
CTAGAGCAAAGTGGCTCATCTTGAGTTCCCATTTTCATTTCACTGACAGACTGCCATCCTCAAGGAGTACTCAGACTGGCCTTCTGTTCA
TGGCTTAGGAGAGCCTTGGTGTGCCTAACTGATTTTTCAAAATTTAGATTTTTTTAGCCTACCAGTGAAAAATGACCCCTTCATCATCAG
GCTCTGCGTTCTACCAAATTGTATGTAAAAAGACACATCTGTTTTGTGGTAGGATTTTTTCACATTTTTGGGTACTATGAGCTGCATTGA
TGGAAGACAGCAGGCAATATGTGGTGACAGTTAACTCACAGACATAAACATGCAAAATACTTTGCTGTCTCTGGGGATATTGCCATTTTT
CTTACTGTGAGCAACAGCACCAACACCAAGTTAACAGGATGCAACATGTGTATGACTCTAAAAGCCCTAAGTAGTTGGTAACTTCCTGGG
CCTTCAATCATAGCAATTTGATGAGGGAAGGAAGGGGAGAGGATTTGTTGGGTAATCAAGACATTCCCGTATATGTCTGATTTCATGGAA
CTGCTCTATTTTGTTTGTGTGTATTGTATATGTATATGTGTATGTGTGCGTGTATGTGTGTGTCTGTAGCTTCAGTTTTTAAGTGTAAGG

>66316_66316_2_PLEKHM2-CENPI_PLEKHM2_chr1_16011113_ENST00000375793_CENPI_chrX_100395655_ENST00000372927_length(amino acids)=316AA_BP=43
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKCSVLQSLKELLQNWLLWLSMDIHMKPVTNSPLETTLGGSM
NSVSKLIHYVGWLSTTAMRLESNNTFLLHFILDFYEKVCDIYINYNLPLVVLFPPGIFYSALLSLDTSILNQLCFIMHRYRKNLTAAKKN
ELVQKTKSEFNFSSKTYQEFNHYLTSMVGCLWTSKPFGKGIYIDPEILEKTGVAEYKNSLNVVHHPSFLSYAVSFLLQESPEERTVNVSS

--------------------------------------------------------------
>66316_66316_3_PLEKHM2-CENPI_PLEKHM2_chr1_16011113_ENST00000375793_CENPI_chrX_100395655_ENST00000423383_length(transcript)=1499nt_BP=229nt
AGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGGGCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGC
CCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGGGCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGG
GGAGGTGAAGGACCGGATCCTGGAGAACATCTCGCTGTCGGTGAAGAAGTGTAGTGTGCTTCAGAGTCTGAAAGAGCTATTGCAGAATTG
GCTGTTGTGGCTTTCTATGGACATTCACATGAAACCTGTTACAAACAGTCCTCTAGAGACAACTTTGGGTGGATCCATGAACTCTGTGTC
TAAACTGATCCACTATGTAGGGTGGCTATCCACTACTGCAATGCGCTTGGAGAGCAACAATACTTTCTTGCTGCACTTTATTTTGGATTT
CTATGAGAAGGTGTGTGACATATATATAAATTATAACCTTCCATTAGTGGTATTGTTTCCTCCTGGGATCTTCTATTCTGCACTCCTCAG
CCTGGATACCAGCATCCTGAACCAGCTGTGTTTTATTATGCACAGATATCGTAAAAATTTGACTGCCGCAAAGAAAAATGAGTTGGTACA
AAAGACAAAATCAGAGTTCAATTTCAGCAGCAAGACTTATCAAGAATTTAATCACTATTTGACATCAATGGTTGGTTGCCTGTGGACGTC
CAAACCCTTTGGGAAAGGAATATATATTGACCCTGAAATCCTAGAAAAAACTGGAGTGGCTGAATATAAAAACAGTTTAAATGTAGTCCA
TCATCCTTCTTTCTTGAGTTACGCTGTTTCCTTTTTGCTACAGGAAAGCCCAGAAGAAAGGACAGTAAATGTGAGCTCTATTCGGGGAAA
GAAATGGAGCTGGTATTTGGACTATTTATTTTCACAGGGGTTACAAGGCTTGAAACTTTTTATAAGAAGTAGTGTTCATCATTCTTCCAT
TCCCAGAGCAGAGGGCATAAACTGCAACAATCAATATTAAATGAATGTTGACATAAACTGAACACACTGGACTAAACTCACTCCTCATTG
CTAGAGCAAAGTGGCTCATCTTGAGTTCCCATTTTCATTTCACTGACAGACTGCCATCCTCAAGGAGTACTCAGACTGGCCTTCTGTTCA
TGGCTTAGGAGAGCCTTGGTGTGCCTAACTGATTTTTCAAAATTTAGATTTTTTTAGCCTACCAGTGAAAAATGACCCCTTCATCATCAG
GCTCTGCGTTCTACCAAATTGTATGTAAAAAGACACATCTGTTTTGTGGTAGGATTTTTTCACATTTTTGGGTACTATGAGCTGCATTGA
TGGAAGACAGCAGGCAATATGTGGTGACAGTTAACTCACAGACATAAACATGCAAAATACTTTGCTGTCTCTGGGGATATTGCCATTTTT

>66316_66316_3_PLEKHM2-CENPI_PLEKHM2_chr1_16011113_ENST00000375793_CENPI_chrX_100395655_ENST00000423383_length(amino acids)=316AA_BP=43
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKCSVLQSLKELLQNWLLWLSMDIHMKPVTNSPLETTLGGSM
NSVSKLIHYVGWLSTTAMRLESNNTFLLHFILDFYEKVCDIYINYNLPLVVLFPPGIFYSALLSLDTSILNQLCFIMHRYRKNLTAAKKN
ELVQKTKSEFNFSSKTYQEFNHYLTSMVGCLWTSKPFGKGIYIDPEILEKTGVAEYKNSLNVVHHPSFLSYAVSFLLQESPEERTVNVSS

--------------------------------------------------------------
>66316_66316_4_PLEKHM2-CENPI_PLEKHM2_chr1_16011113_ENST00000375799_CENPI_chrX_100395655_ENST00000218507_length(transcript)=1515nt_BP=287nt
GCCTCCTTCCCCGCCGGCCGCGCTCCGGAGCCTCCGGGCCGCGGTGGAGCGAGGGCCCAGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGG
GCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGCCCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGG
GCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGGGGAGGTGAAGGACCGGATCCTGGAGAACATCT
CGCTGTCGGTGAAGAAGTGTAGTGTGCTTCAGAGTCTGAAAGAGCTATTGCAGAATTGGCTGTTGTGGCTTTCTATGGACATTCACATGA
AACCTGTTACAAACAGTCCTCTAGAGACAACTTTGGGTGGATCCATGAACTCTGTGTCTAAACTGATCCACTATGTAGGGTGGCTATCCA
CTACTGCAATGCGCTTGGAGAGCAACAATACTTTCTTGCTGCACTTTATTTTGGATTTCTATGAGAAGGTGTGTGACATATATATAAATT
ATAACCTTCCATTAGTGGTATTGTTTCCTCCTGGGATCTTCTATTCTGCACTCCTCAGCCTGGATACCAGCATCCTGAACCAGCTGTGTT
TTATTATGCACAGATATCGTAAAAATTTGACTGCCGCAAAGAAAAATGAGTTGGTACAAAAGACAAAATCAGAGTTCAATTTCAGCAGCA
AGACTTATCAAGAATTTAATCACTATTTGACATCAATGGTTGGTTGCCTGTGGACGTCCAAACCCTTTGGGAAAGGAATATATATTGACC
CTGAAATCCTAGAAAAAACTGGAGTGGCTGAATATAAAAACAGTTTAAATGTAGTCCATCATCCTTCTTTCTTGAGTTACGCTGTTTCCT
TTTTGCTACAGGGAAAGAAATGGAGCTGGTATTTGGACTATTTATTTTCACAGGGGTTACAAGGCTTGAAACTTTTTATAAGAAGTAGTG
TTCATCATTCTTCCATTCCCAGAGCAGAGGGCATAAACTGCAACAATCAATATTAAATGAATGTTGACATAAACTGAACACACTGGACTA
AACTCACTCCTCATTGCTAGAGCAAAGTGGCTCATCTTGAGTTCCCATTTTCATTTCACTGACAGACTGCCATCCTCAAGGAGTACTCAG
ACTGGCCTTCTGTTCATGGCTTAGGAGAGCCTTGGTGTGCCTAACTGATTTTTCAAAATTTAGATTTTTTTAGCCTACCAGTGAAAAATG
ACCCCTTCATCATCAGGCTCTGCGTTCTACCAAATTGTATGTAAAAAGACACATCTGTTTTGTGGTAGGATTTTTTCACATTTTTGGGTA
CTATGAGCTGCATTGATGGAAGACAGCAGGCAATATGTGGTGACAGTTAACTCACAGACATAAACATGCAAAATACTTTGCTGTCTCTGG

>66316_66316_4_PLEKHM2-CENPI_PLEKHM2_chr1_16011113_ENST00000375799_CENPI_chrX_100395655_ENST00000218507_length(amino acids)=302AA_BP=43
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKCSVLQSLKELLQNWLLWLSMDIHMKPVTNSPLETTLGGSM
NSVSKLIHYVGWLSTTAMRLESNNTFLLHFILDFYEKVCDIYINYNLPLVVLFPPGIFYSALLSLDTSILNQLCFIMHRYRKNLTAAKKN
ELVQKTKSEFNFSSKTYQEFNHYLTSMVGCLWTSKPFGKGIYIDPEILEKTGVAEYKNSLNVVHHPSFLSYAVSFLLQGKKWSWYLDYLF

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>66316_66316_5_PLEKHM2-CENPI_PLEKHM2_chr1_16011113_ENST00000375799_CENPI_chrX_100395655_ENST00000372927_length(transcript)=1802nt_BP=287nt
GCCTCCTTCCCCGCCGGCCGCGCTCCGGAGCCTCCGGGCCGCGGTGGAGCGAGGGCCCAGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGG
GCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGCCCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGG
GCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGGGGAGGTGAAGGACCGGATCCTGGAGAACATCT
CGCTGTCGGTGAAGAAGTGTAGTGTGCTTCAGAGTCTGAAAGAGCTATTGCAGAATTGGCTGTTGTGGCTTTCTATGGACATTCACATGA
AACCTGTTACAAACAGTCCTCTAGAGACAACTTTGGGTGGATCCATGAACTCTGTGTCTAAACTGATCCACTATGTAGGGTGGCTATCCA
CTACTGCAATGCGCTTGGAGAGCAACAATACTTTCTTGCTGCACTTTATTTTGGATTTCTATGAGAAGGTGTGTGACATATATATAAATT
ATAACCTTCCATTAGTGGTATTGTTTCCTCCTGGGATCTTCTATTCTGCACTCCTCAGCCTGGATACCAGCATCCTGAACCAGCTGTGTT
TTATTATGCACAGATATCGTAAAAATTTGACTGCCGCAAAGAAAAATGAGTTGGTACAAAAGACAAAATCAGAGTTCAATTTCAGCAGCA
AGACTTATCAAGAATTTAATCACTATTTGACATCAATGGTTGGTTGCCTGTGGACGTCCAAACCCTTTGGGAAAGGAATATATATTGACC
CTGAAATCCTAGAAAAAACTGGAGTGGCTGAATATAAAAACAGTTTAAATGTAGTCCATCATCCTTCTTTCTTGAGTTACGCTGTTTCCT
TTTTGCTACAGGAAAGCCCAGAAGAAAGGACAGTAAATGTGAGCTCTATTCGGGGAAAGAAATGGAGCTGGTATTTGGACTATTTATTTT
CACAGGGGTTACAAGGCTTGAAACTTTTTATAAGAAGTAGTGTTCATCATTCTTCCATTCCCAGAGCAGAGGGCATAAACTGCAACAATC
AATATTAAATGAATGTTGACATAAACTGAACACACTGGACTAAACTCACTCCTCATTGCTAGAGCAAAGTGGCTCATCTTGAGTTCCCAT
TTTCATTTCACTGACAGACTGCCATCCTCAAGGAGTACTCAGACTGGCCTTCTGTTCATGGCTTAGGAGAGCCTTGGTGTGCCTAACTGA
TTTTTCAAAATTTAGATTTTTTTAGCCTACCAGTGAAAAATGACCCCTTCATCATCAGGCTCTGCGTTCTACCAAATTGTATGTAAAAAG
ACACATCTGTTTTGTGGTAGGATTTTTTCACATTTTTGGGTACTATGAGCTGCATTGATGGAAGACAGCAGGCAATATGTGGTGACAGTT
AACTCACAGACATAAACATGCAAAATACTTTGCTGTCTCTGGGGATATTGCCATTTTTCTTACTGTGAGCAACAGCACCAACACCAAGTT
AACAGGATGCAACATGTGTATGACTCTAAAAGCCCTAAGTAGTTGGTAACTTCCTGGGCCTTCAATCATAGCAATTTGATGAGGGAAGGA
AGGGGAGAGGATTTGTTGGGTAATCAAGACATTCCCGTATATGTCTGATTTCATGGAACTGCTCTATTTTGTTTGTGTGTATTGTATATG
TATATGTGTATGTGTGCGTGTATGTGTGTGTCTGTAGCTTCAGTTTTTAAGTGTAAGGACTAAATAAACTAACTGAAATTTTACTTTCAG

>66316_66316_5_PLEKHM2-CENPI_PLEKHM2_chr1_16011113_ENST00000375799_CENPI_chrX_100395655_ENST00000372927_length(amino acids)=316AA_BP=43
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKCSVLQSLKELLQNWLLWLSMDIHMKPVTNSPLETTLGGSM
NSVSKLIHYVGWLSTTAMRLESNNTFLLHFILDFYEKVCDIYINYNLPLVVLFPPGIFYSALLSLDTSILNQLCFIMHRYRKNLTAAKKN
ELVQKTKSEFNFSSKTYQEFNHYLTSMVGCLWTSKPFGKGIYIDPEILEKTGVAEYKNSLNVVHHPSFLSYAVSFLLQESPEERTVNVSS

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>66316_66316_6_PLEKHM2-CENPI_PLEKHM2_chr1_16011113_ENST00000375799_CENPI_chrX_100395655_ENST00000423383_length(transcript)=1557nt_BP=287nt
GCCTCCTTCCCCGCCGGCCGCGCTCCGGAGCCTCCGGGCCGCGGTGGAGCGAGGGCCCAGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGG
GCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGCCCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGG
GCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGGGGAGGTGAAGGACCGGATCCTGGAGAACATCT
CGCTGTCGGTGAAGAAGTGTAGTGTGCTTCAGAGTCTGAAAGAGCTATTGCAGAATTGGCTGTTGTGGCTTTCTATGGACATTCACATGA
AACCTGTTACAAACAGTCCTCTAGAGACAACTTTGGGTGGATCCATGAACTCTGTGTCTAAACTGATCCACTATGTAGGGTGGCTATCCA
CTACTGCAATGCGCTTGGAGAGCAACAATACTTTCTTGCTGCACTTTATTTTGGATTTCTATGAGAAGGTGTGTGACATATATATAAATT
ATAACCTTCCATTAGTGGTATTGTTTCCTCCTGGGATCTTCTATTCTGCACTCCTCAGCCTGGATACCAGCATCCTGAACCAGCTGTGTT
TTATTATGCACAGATATCGTAAAAATTTGACTGCCGCAAAGAAAAATGAGTTGGTACAAAAGACAAAATCAGAGTTCAATTTCAGCAGCA
AGACTTATCAAGAATTTAATCACTATTTGACATCAATGGTTGGTTGCCTGTGGACGTCCAAACCCTTTGGGAAAGGAATATATATTGACC
CTGAAATCCTAGAAAAAACTGGAGTGGCTGAATATAAAAACAGTTTAAATGTAGTCCATCATCCTTCTTTCTTGAGTTACGCTGTTTCCT
TTTTGCTACAGGAAAGCCCAGAAGAAAGGACAGTAAATGTGAGCTCTATTCGGGGAAAGAAATGGAGCTGGTATTTGGACTATTTATTTT
CACAGGGGTTACAAGGCTTGAAACTTTTTATAAGAAGTAGTGTTCATCATTCTTCCATTCCCAGAGCAGAGGGCATAAACTGCAACAATC
AATATTAAATGAATGTTGACATAAACTGAACACACTGGACTAAACTCACTCCTCATTGCTAGAGCAAAGTGGCTCATCTTGAGTTCCCAT
TTTCATTTCACTGACAGACTGCCATCCTCAAGGAGTACTCAGACTGGCCTTCTGTTCATGGCTTAGGAGAGCCTTGGTGTGCCTAACTGA
TTTTTCAAAATTTAGATTTTTTTAGCCTACCAGTGAAAAATGACCCCTTCATCATCAGGCTCTGCGTTCTACCAAATTGTATGTAAAAAG
ACACATCTGTTTTGTGGTAGGATTTTTTCACATTTTTGGGTACTATGAGCTGCATTGATGGAAGACAGCAGGCAATATGTGGTGACAGTT
AACTCACAGACATAAACATGCAAAATACTTTGCTGTCTCTGGGGATATTGCCATTTTTCTTACTGTGAGCAACAGCACCAACACCAAGTT

>66316_66316_6_PLEKHM2-CENPI_PLEKHM2_chr1_16011113_ENST00000375799_CENPI_chrX_100395655_ENST00000423383_length(amino acids)=316AA_BP=43
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKCSVLQSLKELLQNWLLWLSMDIHMKPVTNSPLETTLGGSM
NSVSKLIHYVGWLSTTAMRLESNNTFLLHFILDFYEKVCDIYINYNLPLVVLFPPGIFYSALLSLDTSILNQLCFIMHRYRKNLTAAKKN
ELVQKTKSEFNFSSKTYQEFNHYLTSMVGCLWTSKPFGKGIYIDPEILEKTGVAEYKNSLNVVHHPSFLSYAVSFLLQESPEERTVNVSS

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Fusion Gene PPI Analysis for PLEKHM2-CENPI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePLEKHM2chr1:16011113chrX:100395655ENST00000375799+1201_31020.01020.0KIF5B
HgenePLEKHM2chr1:16011113chrX:100395655ENST00000375799+120762_88520.01020.0sifA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLEKHM2-CENPI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLEKHM2-CENPI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLEKHM2C1960469Left ventricular noncompaction1ORPHANET