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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:PLCB1-RBL1 (FusionGDB2 ID:HG23236TG5933) |
Fusion Gene Summary for PLCB1-RBL1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: PLCB1-RBL1 | Fusion gene ID: hg23236tg5933 | Hgene | Tgene | Gene symbol | PLCB1 | RBL1 | Gene ID | 23236 | 5933 |
Gene name | phospholipase C beta 1 | RB transcriptional corepressor like 1 | |
Synonyms | EIEE12|PI-PLC|PLC-154|PLC-I|PLC-beta-1|PLC154|PLCB1A|PLCB1B | CP107|PRB1|p107 | |
Cytomap | ('PLCB1')('RBL1') 20p12.3 | 20q11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-11-phosphatidyl-D-myo-inositol-4,5-bisphosphateinositoltrisphosphohydrolasemonophosphatidylinositol phosphodiesterasephosphoinositidase Cphosphoinositide phospholipase Cphospholipase C, | retinoblastoma-like protein 1107 kDa retinoblastoma-associated proteinretinoblastoma-like 1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000338037, ENST00000378637, ENST00000378641, ENST00000494924, | ||
Fusion gene scores | * DoF score | 24 X 20 X 10=4800 | 8 X 9 X 5=360 |
# samples | 22 | 9 | |
** MAII score | log2(22/4800*10)=-4.44745897697122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/360*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PLCB1 [Title/Abstract] AND RBL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | PLCB1(8131018)-RBL1(35651229), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | PLCB1-RBL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PLCB1-RBL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PLCB1 | GO:0035722 | interleukin-12-mediated signaling pathway | 11743656 |
Hgene | PLCB1 | GO:0035723 | interleukin-15-mediated signaling pathway | 11743656 |
Hgene | PLCB1 | GO:0046330 | positive regulation of JNK cascade | 9500449 |
Hgene | PLCB1 | GO:0070498 | interleukin-1-mediated signaling pathway | 8872139 |
Tgene | RBL1 | GO:0043550 | regulation of lipid kinase activity | 16286473 |
Fusion gene breakpoints across PLCB1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across RBL1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUSC | TCGA-22-A5C4-01A | PLCB1 | chr20 | 8131018 | - | RBL1 | chr20 | 35651229 | - |
ChimerDB4 | LUSC | TCGA-22-A5C4-01A | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
ChimerDB4 | LUSC | TCGA-22-A5C4 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
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Fusion Gene ORF analysis for PLCB1-RBL1 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000338037 | ENST00000598590 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
5CDS-intron | ENST00000378637 | ENST00000598590 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
5CDS-intron | ENST00000378641 | ENST00000598590 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
In-frame | ENST00000338037 | ENST00000344359 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
In-frame | ENST00000338037 | ENST00000373664 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
In-frame | ENST00000378637 | ENST00000344359 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
In-frame | ENST00000378637 | ENST00000373664 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
In-frame | ENST00000378641 | ENST00000344359 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
In-frame | ENST00000378641 | ENST00000373664 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
intron-3CDS | ENST00000494924 | ENST00000344359 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
intron-3CDS | ENST00000494924 | ENST00000373664 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
intron-intron | ENST00000494924 | ENST00000598590 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000378641 | PLCB1 | chr20 | 8131018 | + | ENST00000373664 | RBL1 | chr20 | 35651229 | - | 3887 | 652 | 475 | 1476 | 333 |
ENST00000378641 | PLCB1 | chr20 | 8131018 | + | ENST00000344359 | RBL1 | chr20 | 35651229 | - | 1434 | 652 | 475 | 1314 | 279 |
ENST00000338037 | PLCB1 | chr20 | 8131018 | + | ENST00000373664 | RBL1 | chr20 | 35651229 | - | 3439 | 204 | 27 | 1028 | 333 |
ENST00000338037 | PLCB1 | chr20 | 8131018 | + | ENST00000344359 | RBL1 | chr20 | 35651229 | - | 986 | 204 | 27 | 866 | 279 |
ENST00000378637 | PLCB1 | chr20 | 8131018 | + | ENST00000373664 | RBL1 | chr20 | 35651229 | - | 3415 | 180 | 3 | 1004 | 333 |
ENST00000378637 | PLCB1 | chr20 | 8131018 | + | ENST00000344359 | RBL1 | chr20 | 35651229 | - | 962 | 180 | 3 | 842 | 279 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000378641 | ENST00000373664 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - | 0.000258124 | 0.99974185 |
ENST00000378641 | ENST00000344359 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - | 0.00155957 | 0.99844044 |
ENST00000338037 | ENST00000373664 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - | 0.000185669 | 0.99981433 |
ENST00000338037 | ENST00000344359 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - | 0.000512599 | 0.9994874 |
ENST00000378637 | ENST00000373664 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - | 0.000184978 | 0.99981505 |
ENST00000378637 | ENST00000344359 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - | 0.000481396 | 0.99951863 |
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Fusion Genomic Features for PLCB1-RBL1 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for PLCB1-RBL1 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:8131018/chr20:35651229) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PLCB1 | chr20:8131018 | chr20:35651229 | ENST00000338037 | + | 2 | 32 | 316_467 | 59 | 1217.0 | Domain | PI-PLC X-box |
Hgene | PLCB1 | chr20:8131018 | chr20:35651229 | ENST00000338037 | + | 2 | 32 | 540_656 | 59 | 1217.0 | Domain | PI-PLC Y-box |
Hgene | PLCB1 | chr20:8131018 | chr20:35651229 | ENST00000338037 | + | 2 | 32 | 656_786 | 59 | 1217.0 | Domain | C2 |
Hgene | PLCB1 | chr20:8131018 | chr20:35651229 | ENST00000378637 | + | 2 | 32 | 316_467 | 59 | 1174.0 | Domain | PI-PLC X-box |
Hgene | PLCB1 | chr20:8131018 | chr20:35651229 | ENST00000378637 | + | 2 | 32 | 540_656 | 59 | 1174.0 | Domain | PI-PLC Y-box |
Hgene | PLCB1 | chr20:8131018 | chr20:35651229 | ENST00000378637 | + | 2 | 32 | 656_786 | 59 | 1174.0 | Domain | C2 |
Hgene | PLCB1 | chr20:8131018 | chr20:35651229 | ENST00000378641 | + | 2 | 33 | 316_467 | 59 | 2075.6666666666665 | Domain | PI-PLC X-box |
Hgene | PLCB1 | chr20:8131018 | chr20:35651229 | ENST00000378641 | + | 2 | 33 | 540_656 | 59 | 2075.6666666666665 | Domain | PI-PLC Y-box |
Hgene | PLCB1 | chr20:8131018 | chr20:35651229 | ENST00000378641 | + | 2 | 33 | 656_786 | 59 | 2075.6666666666665 | Domain | C2 |
Tgene | RBL1 | chr20:8131018 | chr20:35651229 | ENST00000344359 | 15 | 21 | 385_584 | 794 | 1015.0 | Region | Domain A | |
Tgene | RBL1 | chr20:8131018 | chr20:35651229 | ENST00000344359 | 15 | 21 | 385_949 | 794 | 1015.0 | Region | Pocket%3B binds T and E1A | |
Tgene | RBL1 | chr20:8131018 | chr20:35651229 | ENST00000344359 | 15 | 21 | 585_780 | 794 | 1015.0 | Region | Spacer | |
Tgene | RBL1 | chr20:8131018 | chr20:35651229 | ENST00000344359 | 15 | 21 | 781_949 | 794 | 1015.0 | Region | Domain B | |
Tgene | RBL1 | chr20:8131018 | chr20:35651229 | ENST00000373664 | 15 | 22 | 385_584 | 794 | 1069.0 | Region | Domain A | |
Tgene | RBL1 | chr20:8131018 | chr20:35651229 | ENST00000373664 | 15 | 22 | 385_949 | 794 | 1069.0 | Region | Pocket%3B binds T and E1A | |
Tgene | RBL1 | chr20:8131018 | chr20:35651229 | ENST00000373664 | 15 | 22 | 585_780 | 794 | 1069.0 | Region | Spacer | |
Tgene | RBL1 | chr20:8131018 | chr20:35651229 | ENST00000373664 | 15 | 22 | 781_949 | 794 | 1069.0 | Region | Domain B |
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Fusion Gene Sequence for PLCB1-RBL1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>65969_65969_1_PLCB1-RBL1_PLCB1_chr20_8131018_ENST00000338037_RBL1_chr20_35651229_ENST00000344359_length(transcript)=986nt_BP=204nt GGCCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGC CTCAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTC TTTTACTGGACAGATCAAAACAAGGTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTA CGAAGGAAGATATGGACGTGTTTTGAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGT GCCTTTTATATCATGGCAAAGGTAACAAAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGT CACGTATATAGAAGTGTTCTGCTGAAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGAT TGTGACTTAGAAGATGCTACAAAAACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACA ATATATGTAGGAAGAGTGAAGTCATTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTT CCACATATTAAACAACAGCCAGGCTCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTT ACACCAAGAAGCGCTCTGCTGTACAAGTTCAATGGCAGCCCTTCTAAGGTAAGGTGAATAGGCTAAAAGTTGGATTTCAGATTAACAGTC >65969_65969_1_PLCB1-RBL1_PLCB1_chr20_8131018_ENST00000338037_RBL1_chr20_35651229_ENST00000344359_length(amino acids)=279AA_BP=59 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKT PDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYK -------------------------------------------------------------- >65969_65969_2_PLCB1-RBL1_PLCB1_chr20_8131018_ENST00000338037_RBL1_chr20_35651229_ENST00000373664_length(transcript)=3439nt_BP=204nt GGCCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGC CTCAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTC TTTTACTGGACAGATCAAAACAAGGTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTA CGAAGGAAGATATGGACGTGTTTTGAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGT GCCTTTTATATCATGGCAAAGGTAACAAAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGT CACGTATATAGAAGTGTTCTGCTGAAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGAT TGTGACTTAGAAGATGCTACAAAAACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACA ATATATGTAGGAAGAGTGAAGTCATTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTT CCACATATTAAACAACAGCCAGGCTCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTT ACACCAAGAAGCGCTCTGCTGTACAAGTTCAATGGCAGCCCTTCTAAGAGTTTGAAAGATATCAACAACATGATAAGGCAAGGTGAGCAG AGAACCAAGAAGCGAGTAATAGCCATCGATAGTGATGCAGAATCCCCTGCCAAACGCGTCTGTCAAGAAAATGATGACGTTTTACTGAAA CGACTACAGGATGTTGTCAGTGAAAGAGCAAATCATTAATGTTGTTCTTGTTTCTATGATAAAAGCACTTTCAGATTGTTCTGCAGAAAG TTGGAGCTCTGTCCTTCAAACCTTTTAGCCCTATAGATGATAAATATCACTGGGTTATAAGAAAAAATTGCACAAAAATTATGTGCTTTT TAAAATATTTATCCAAAATGTAGTTGACAGAGATGTATTTTGAGTTGGATTGGAAAGGAATATTTTAAGTGCCTTTTAAAAATACTAATA GTCCGGCCAGGCGCTGTGGCTCACGCCTGTAATCCCAGGACTTTGGGAGGCCAAGGCGGGCAGATCACCGGAGGTCAGGAGTTCGAGACC AGCCTGACCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGCCGGGTGTGGTGGCGCATGCCTGTAATCCCAGCTACTTGG GAGGCTGAGGCAGAATTGCTTGAACCCAGGAAGCGGAGGTTGTGGTGAGCCAAGGTTGCGCCACTGCACTCCAGCCTGGGCAACAAGAGT AAAACTCCATCTCAAAAAATATATATATATATATAAATAGGGAATTTTTTTTAATGTTTGCTCCTTGAGTTTTCAAGATGAAATAAGGAG AAACCCCATAACTTTTTAGCTCTCTTTTAAAAATAAATGTCTCCTTCTGTGTTCTGTAATATGAGGATAAATAATCTACTTTTGATAGCA TGCTTTGAGATATTTGTATTCTTAATTTAATATTGAAGGAAGGGGTTGGTTCCCATAGTACCTGGCCAGAGGGTTATATACCATCCTGTC TCTGGCCCACTGTGGTAATTCCACATCCAGGTACCACCGCCATTCAGAGTTGTCTCACCCCTTCTCGTGCCTTTTCTCTCCTTGAGCTTT ATAAACAGATTTGTACCTGAGCCCCAGTGCTACACTCATCCTTGCTTTCCAGCCCTAAGCCATCTCAGCCTGATGTCACAACCCAATAAA TGGGGCACTTTCTTCTTTTGTAAACTATTATCATTTTGGTTTCTGTGACATTAACTTAATTATATATGATCGTATTAACTCATGTAGTTC TCAAAATAGGCAGCTGCTTCTGAAGCCAGTAAAATAAAATTCAGTTAGTTATTAAAAACTAAATTCCTATTAGTAAGGTAACACCATGAT TATGTGTGATATACTGTTTTTGAGATCATAGTTATCAGTCATTCTCAATATCTAATTGAGTCCCTAAGAATATTTTAAACCTTTTAAAAA TCACATAAATATCATCTCATGCCTCATAATTCTAATATATTTAATACATCAGTAAAATAGCTGCTTATTACTTCCCACACTTTGTTCTCA GTATTGTTAGTGCATCATGAGTTTCCTGCTAGTGTTTGACCACTGGGTACTCCTGAAGATGTTTTTTAGTACTAGGGATGCTTTTCAGTA TTAGGGATGCTTTTTTCAGTACTAGGGATGTACTAGGGAGTACTGAGTACTCCTGAAGATGTTTTTCAGTACTAGGGATGCTTTTTTCAG TGTTAGGGATGCTTTTCAGTACTAGGGATGCTTTTTTCAGTGCTAGGGATGCTTTTCAGTACTAGGGATGCTTTCCAAAATATCACCTCT TTAACGTTTACTTTTTCTAGTGTGTGTCTGGAATCCAAAGGACATGAATAAGCCACTCATAATTAATTTTGAGAAGTTTTATCAAATGTT TATGTTTCTAACTGCAAACCTTAATTTTGGAAAGGCACAATGTTTAACTCACCTATGTTTAACCATGGCTAATTTAAAATAGTCTAAGAT TTGGCCGTCACTAATTAGTATTCTCAAGAATTTCATTTTTCAATTTTAAGAAGAAAAGGGATTTTGGTCACATTTTGCTTGTAAATGAAA ATTACATCCTCATTCTTTGTGTAGTATCTACACATTGTTATAAGCCAAAAAACAAAGTCTGTCTGGAATCTTTGTACATATTTGTATGTT GCTATAATTGTTATTTTTATCTTCATTATTGTGCAAAATATAAATGAGCATTTGTACATTGACTGTATAAGAAACCATGGGCCAGGTCCT GTGGCTCATGCCTATAATCCCAACACTTTGGGAGGCTGAGGCAGGAGGATTGCTTCAGTCCAGGAGTTCAAGACTAACCTGGGCAACATA GCCCTCATCTCTACAAAAAATAAAAAAATTAGTTGGGTGTGATGGCATGTGCCTGTAGTCCCAGCTACTCAGGAGACTGACATGAGAGGA TCACTTGAGACTGGGAGATTCTGAGGCTGCAGTGAGCTGTGATTGCACCACTACACTCCATCCTAGGTGAGAGGGCAAGACCCTTTCTCA GAAAAGGAAAAAAAGAAATTCTGGACATGTTTTTATCAGTTTTCAGGACTTGGTATCAATGTACATAGAATGGCTAATAAAAATTGGAAT >65969_65969_2_PLCB1-RBL1_PLCB1_chr20_8131018_ENST00000338037_RBL1_chr20_35651229_ENST00000373664_length(amino acids)=333AA_BP=59 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKT PDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYK -------------------------------------------------------------- >65969_65969_3_PLCB1-RBL1_PLCB1_chr20_8131018_ENST00000378637_RBL1_chr20_35651229_ENST00000344359_length(transcript)=962nt_BP=180nt CAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTC AAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAG GTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACGAAGGAAGATATGGACGTGTTTT GAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGTGCCTTTTATATCATGGCAAAGGTA ACAAAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCACGTATATAGAAGTGTTCTGCTG AAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTGTGACTTAGAAGATGCTACAAAA ACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAATATATGTAGGAAGAGTGAAGTCA TTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTTCCACATATTAAACAACAGCCAGGC TCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTACACCAAGAAGCGCTCTGCTGTAC AAGTTCAATGGCAGCCCTTCTAAGGTAAGGTGAATAGGCTAAAAGTTGGATTTCAGATTAACAGTCAGTAACTGTTAATCCTGCCTCTTT >65969_65969_3_PLCB1-RBL1_PLCB1_chr20_8131018_ENST00000378637_RBL1_chr20_35651229_ENST00000344359_length(amino acids)=279AA_BP=59 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKT PDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYK -------------------------------------------------------------- >65969_65969_4_PLCB1-RBL1_PLCB1_chr20_8131018_ENST00000378637_RBL1_chr20_35651229_ENST00000373664_length(transcript)=3415nt_BP=180nt CAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTC AAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAG GTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACGAAGGAAGATATGGACGTGTTTT GAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGTGCCTTTTATATCATGGCAAAGGTA ACAAAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCACGTATATAGAAGTGTTCTGCTG AAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTGTGACTTAGAAGATGCTACAAAA ACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAATATATGTAGGAAGAGTGAAGTCA TTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTTCCACATATTAAACAACAGCCAGGC TCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTACACCAAGAAGCGCTCTGCTGTAC AAGTTCAATGGCAGCCCTTCTAAGAGTTTGAAAGATATCAACAACATGATAAGGCAAGGTGAGCAGAGAACCAAGAAGCGAGTAATAGCC ATCGATAGTGATGCAGAATCCCCTGCCAAACGCGTCTGTCAAGAAAATGATGACGTTTTACTGAAACGACTACAGGATGTTGTCAGTGAA AGAGCAAATCATTAATGTTGTTCTTGTTTCTATGATAAAAGCACTTTCAGATTGTTCTGCAGAAAGTTGGAGCTCTGTCCTTCAAACCTT TTAGCCCTATAGATGATAAATATCACTGGGTTATAAGAAAAAATTGCACAAAAATTATGTGCTTTTTAAAATATTTATCCAAAATGTAGT TGACAGAGATGTATTTTGAGTTGGATTGGAAAGGAATATTTTAAGTGCCTTTTAAAAATACTAATAGTCCGGCCAGGCGCTGTGGCTCAC GCCTGTAATCCCAGGACTTTGGGAGGCCAAGGCGGGCAGATCACCGGAGGTCAGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCC CATCTCTACTAAAAATACAAAATTAGCCGGGTGTGGTGGCGCATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGAATTGCTTGAA CCCAGGAAGCGGAGGTTGTGGTGAGCCAAGGTTGCGCCACTGCACTCCAGCCTGGGCAACAAGAGTAAAACTCCATCTCAAAAAATATAT ATATATATATAAATAGGGAATTTTTTTTAATGTTTGCTCCTTGAGTTTTCAAGATGAAATAAGGAGAAACCCCATAACTTTTTAGCTCTC TTTTAAAAATAAATGTCTCCTTCTGTGTTCTGTAATATGAGGATAAATAATCTACTTTTGATAGCATGCTTTGAGATATTTGTATTCTTA ATTTAATATTGAAGGAAGGGGTTGGTTCCCATAGTACCTGGCCAGAGGGTTATATACCATCCTGTCTCTGGCCCACTGTGGTAATTCCAC ATCCAGGTACCACCGCCATTCAGAGTTGTCTCACCCCTTCTCGTGCCTTTTCTCTCCTTGAGCTTTATAAACAGATTTGTACCTGAGCCC CAGTGCTACACTCATCCTTGCTTTCCAGCCCTAAGCCATCTCAGCCTGATGTCACAACCCAATAAATGGGGCACTTTCTTCTTTTGTAAA CTATTATCATTTTGGTTTCTGTGACATTAACTTAATTATATATGATCGTATTAACTCATGTAGTTCTCAAAATAGGCAGCTGCTTCTGAA GCCAGTAAAATAAAATTCAGTTAGTTATTAAAAACTAAATTCCTATTAGTAAGGTAACACCATGATTATGTGTGATATACTGTTTTTGAG ATCATAGTTATCAGTCATTCTCAATATCTAATTGAGTCCCTAAGAATATTTTAAACCTTTTAAAAATCACATAAATATCATCTCATGCCT CATAATTCTAATATATTTAATACATCAGTAAAATAGCTGCTTATTACTTCCCACACTTTGTTCTCAGTATTGTTAGTGCATCATGAGTTT CCTGCTAGTGTTTGACCACTGGGTACTCCTGAAGATGTTTTTTAGTACTAGGGATGCTTTTCAGTATTAGGGATGCTTTTTTCAGTACTA GGGATGTACTAGGGAGTACTGAGTACTCCTGAAGATGTTTTTCAGTACTAGGGATGCTTTTTTCAGTGTTAGGGATGCTTTTCAGTACTA GGGATGCTTTTTTCAGTGCTAGGGATGCTTTTCAGTACTAGGGATGCTTTCCAAAATATCACCTCTTTAACGTTTACTTTTTCTAGTGTG TGTCTGGAATCCAAAGGACATGAATAAGCCACTCATAATTAATTTTGAGAAGTTTTATCAAATGTTTATGTTTCTAACTGCAAACCTTAA TTTTGGAAAGGCACAATGTTTAACTCACCTATGTTTAACCATGGCTAATTTAAAATAGTCTAAGATTTGGCCGTCACTAATTAGTATTCT CAAGAATTTCATTTTTCAATTTTAAGAAGAAAAGGGATTTTGGTCACATTTTGCTTGTAAATGAAAATTACATCCTCATTCTTTGTGTAG TATCTACACATTGTTATAAGCCAAAAAACAAAGTCTGTCTGGAATCTTTGTACATATTTGTATGTTGCTATAATTGTTATTTTTATCTTC ATTATTGTGCAAAATATAAATGAGCATTTGTACATTGACTGTATAAGAAACCATGGGCCAGGTCCTGTGGCTCATGCCTATAATCCCAAC ACTTTGGGAGGCTGAGGCAGGAGGATTGCTTCAGTCCAGGAGTTCAAGACTAACCTGGGCAACATAGCCCTCATCTCTACAAAAAATAAA AAAATTAGTTGGGTGTGATGGCATGTGCCTGTAGTCCCAGCTACTCAGGAGACTGACATGAGAGGATCACTTGAGACTGGGAGATTCTGA GGCTGCAGTGAGCTGTGATTGCACCACTACACTCCATCCTAGGTGAGAGGGCAAGACCCTTTCTCAGAAAAGGAAAAAAAGAAATTCTGG >65969_65969_4_PLCB1-RBL1_PLCB1_chr20_8131018_ENST00000378637_RBL1_chr20_35651229_ENST00000373664_length(amino acids)=333AA_BP=59 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKT PDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYK -------------------------------------------------------------- >65969_65969_5_PLCB1-RBL1_PLCB1_chr20_8131018_ENST00000378641_RBL1_chr20_35651229_ENST00000344359_length(transcript)=1434nt_BP=652nt CAGCGAGCGAGGGTGGCGGGGAAGGGGGGCGGGGGGGAGGAGGAGGGAGGAGGGAAAAGAGCGGTTAGGGGGGGCGCCGGGCGTGTGTCA CTCGCTCTCTCCCTCTGTGTATAGAGGATGTGCTGAATGGTGCGCTTTGAGGCGGCGGCGGCGGAGGAGCAGAATCCGCCGCGACTGGCA GCCTCGGCTGACCGGCTCGGCTTCTCTTCGCCTTCCGAGGCTCCTCATCCACCGCGGGCTCCAGACCTCGCGTCCCGCCCGGGGCATGGC CGGGCGCTGCGCCCCCGCGCGCTCTGCCTGCTGAGCGGCGCCGGAGGGAGGTGCGGAGGCCGGGAGGCCGGGGAGGCCGGCGGGGAGCAG AGTCGAGCGCCTCCGGAGCAGAGAAAGGAGCCCGCGCCCCGCGCCCCGCGCCCCGCGCACGGTCCCCAGTCCCTGCCGCGCTCGCCCGGG CCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCT CAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTT TTACTGGACAGATCAAAACAAGGTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACG AAGGAAGATATGGACGTGTTTTGAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGTGC CTTTTATATCATGGCAAAGGTAACAAAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCA CGTATATAGAAGTGTTCTGCTGAAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTG TGACTTAGAAGATGCTACAAAAACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAAT ATATGTAGGAAGAGTGAAGTCATTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTTCC ACATATTAAACAACAGCCAGGCTCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTAC ACCAAGAAGCGCTCTGCTGTACAAGTTCAATGGCAGCCCTTCTAAGGTAAGGTGAATAGGCTAAAAGTTGGATTTCAGATTAACAGTCAG >65969_65969_5_PLCB1-RBL1_PLCB1_chr20_8131018_ENST00000378641_RBL1_chr20_35651229_ENST00000344359_length(amino acids)=279AA_BP=59 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKT PDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYK -------------------------------------------------------------- >65969_65969_6_PLCB1-RBL1_PLCB1_chr20_8131018_ENST00000378641_RBL1_chr20_35651229_ENST00000373664_length(transcript)=3887nt_BP=652nt CAGCGAGCGAGGGTGGCGGGGAAGGGGGGCGGGGGGGAGGAGGAGGGAGGAGGGAAAAGAGCGGTTAGGGGGGGCGCCGGGCGTGTGTCA CTCGCTCTCTCCCTCTGTGTATAGAGGATGTGCTGAATGGTGCGCTTTGAGGCGGCGGCGGCGGAGGAGCAGAATCCGCCGCGACTGGCA GCCTCGGCTGACCGGCTCGGCTTCTCTTCGCCTTCCGAGGCTCCTCATCCACCGCGGGCTCCAGACCTCGCGTCCCGCCCGGGGCATGGC CGGGCGCTGCGCCCCCGCGCGCTCTGCCTGCTGAGCGGCGCCGGAGGGAGGTGCGGAGGCCGGGAGGCCGGGGAGGCCGGCGGGGAGCAG AGTCGAGCGCCTCCGGAGCAGAGAAAGGAGCCCGCGCCCCGCGCCCCGCGCCCCGCGCACGGTCCCCAGTCCCTGCCGCGCTCGCCCGGG CCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCT CAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTT TTACTGGACAGATCAAAACAAGGTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACG AAGGAAGATATGGACGTGTTTTGAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGTGC CTTTTATATCATGGCAAAGGTAACAAAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCA CGTATATAGAAGTGTTCTGCTGAAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTG TGACTTAGAAGATGCTACAAAAACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAAT ATATGTAGGAAGAGTGAAGTCATTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTTCC ACATATTAAACAACAGCCAGGCTCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTAC ACCAAGAAGCGCTCTGCTGTACAAGTTCAATGGCAGCCCTTCTAAGAGTTTGAAAGATATCAACAACATGATAAGGCAAGGTGAGCAGAG AACCAAGAAGCGAGTAATAGCCATCGATAGTGATGCAGAATCCCCTGCCAAACGCGTCTGTCAAGAAAATGATGACGTTTTACTGAAACG ACTACAGGATGTTGTCAGTGAAAGAGCAAATCATTAATGTTGTTCTTGTTTCTATGATAAAAGCACTTTCAGATTGTTCTGCAGAAAGTT GGAGCTCTGTCCTTCAAACCTTTTAGCCCTATAGATGATAAATATCACTGGGTTATAAGAAAAAATTGCACAAAAATTATGTGCTTTTTA AAATATTTATCCAAAATGTAGTTGACAGAGATGTATTTTGAGTTGGATTGGAAAGGAATATTTTAAGTGCCTTTTAAAAATACTAATAGT CCGGCCAGGCGCTGTGGCTCACGCCTGTAATCCCAGGACTTTGGGAGGCCAAGGCGGGCAGATCACCGGAGGTCAGGAGTTCGAGACCAG CCTGACCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGCCGGGTGTGGTGGCGCATGCCTGTAATCCCAGCTACTTGGGA GGCTGAGGCAGAATTGCTTGAACCCAGGAAGCGGAGGTTGTGGTGAGCCAAGGTTGCGCCACTGCACTCCAGCCTGGGCAACAAGAGTAA AACTCCATCTCAAAAAATATATATATATATATAAATAGGGAATTTTTTTTAATGTTTGCTCCTTGAGTTTTCAAGATGAAATAAGGAGAA ACCCCATAACTTTTTAGCTCTCTTTTAAAAATAAATGTCTCCTTCTGTGTTCTGTAATATGAGGATAAATAATCTACTTTTGATAGCATG CTTTGAGATATTTGTATTCTTAATTTAATATTGAAGGAAGGGGTTGGTTCCCATAGTACCTGGCCAGAGGGTTATATACCATCCTGTCTC TGGCCCACTGTGGTAATTCCACATCCAGGTACCACCGCCATTCAGAGTTGTCTCACCCCTTCTCGTGCCTTTTCTCTCCTTGAGCTTTAT AAACAGATTTGTACCTGAGCCCCAGTGCTACACTCATCCTTGCTTTCCAGCCCTAAGCCATCTCAGCCTGATGTCACAACCCAATAAATG GGGCACTTTCTTCTTTTGTAAACTATTATCATTTTGGTTTCTGTGACATTAACTTAATTATATATGATCGTATTAACTCATGTAGTTCTC AAAATAGGCAGCTGCTTCTGAAGCCAGTAAAATAAAATTCAGTTAGTTATTAAAAACTAAATTCCTATTAGTAAGGTAACACCATGATTA TGTGTGATATACTGTTTTTGAGATCATAGTTATCAGTCATTCTCAATATCTAATTGAGTCCCTAAGAATATTTTAAACCTTTTAAAAATC ACATAAATATCATCTCATGCCTCATAATTCTAATATATTTAATACATCAGTAAAATAGCTGCTTATTACTTCCCACACTTTGTTCTCAGT ATTGTTAGTGCATCATGAGTTTCCTGCTAGTGTTTGACCACTGGGTACTCCTGAAGATGTTTTTTAGTACTAGGGATGCTTTTCAGTATT AGGGATGCTTTTTTCAGTACTAGGGATGTACTAGGGAGTACTGAGTACTCCTGAAGATGTTTTTCAGTACTAGGGATGCTTTTTTCAGTG TTAGGGATGCTTTTCAGTACTAGGGATGCTTTTTTCAGTGCTAGGGATGCTTTTCAGTACTAGGGATGCTTTCCAAAATATCACCTCTTT AACGTTTACTTTTTCTAGTGTGTGTCTGGAATCCAAAGGACATGAATAAGCCACTCATAATTAATTTTGAGAAGTTTTATCAAATGTTTA TGTTTCTAACTGCAAACCTTAATTTTGGAAAGGCACAATGTTTAACTCACCTATGTTTAACCATGGCTAATTTAAAATAGTCTAAGATTT GGCCGTCACTAATTAGTATTCTCAAGAATTTCATTTTTCAATTTTAAGAAGAAAAGGGATTTTGGTCACATTTTGCTTGTAAATGAAAAT TACATCCTCATTCTTTGTGTAGTATCTACACATTGTTATAAGCCAAAAAACAAAGTCTGTCTGGAATCTTTGTACATATTTGTATGTTGC TATAATTGTTATTTTTATCTTCATTATTGTGCAAAATATAAATGAGCATTTGTACATTGACTGTATAAGAAACCATGGGCCAGGTCCTGT GGCTCATGCCTATAATCCCAACACTTTGGGAGGCTGAGGCAGGAGGATTGCTTCAGTCCAGGAGTTCAAGACTAACCTGGGCAACATAGC CCTCATCTCTACAAAAAATAAAAAAATTAGTTGGGTGTGATGGCATGTGCCTGTAGTCCCAGCTACTCAGGAGACTGACATGAGAGGATC ACTTGAGACTGGGAGATTCTGAGGCTGCAGTGAGCTGTGATTGCACCACTACACTCCATCCTAGGTGAGAGGGCAAGACCCTTTCTCAGA AAAGGAAAAAAAGAAATTCTGGACATGTTTTTATCAGTTTTCAGGACTTGGTATCAATGTACATAGAATGGCTAATAAAAATTGGAATTG >65969_65969_6_PLCB1-RBL1_PLCB1_chr20_8131018_ENST00000378641_RBL1_chr20_35651229_ENST00000373664_length(amino acids)=333AA_BP=59 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKT PDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PLCB1-RBL1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PLCB1-RBL1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PLCB1-RBL1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PLCB1 | C0037769 | West Syndrome | 2 | ORPHANET |
Hgene | PLCB1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | PLCB1 | C0007102 | Malignant tumor of colon | 1 | CTD_human |
Hgene | PLCB1 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Hgene | PLCB1 | C0030193 | Pain | 1 | CTD_human |
Hgene | PLCB1 | C0036341 | Schizophrenia | 1 | CTD_human |
Hgene | PLCB1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | PLCB1 | C0234230 | Pain, Burning | 1 | CTD_human |
Hgene | PLCB1 | C0234238 | Ache | 1 | CTD_human |
Hgene | PLCB1 | C0234254 | Radiating pain | 1 | CTD_human |
Hgene | PLCB1 | C0458257 | Pain, Splitting | 1 | CTD_human |
Hgene | PLCB1 | C0458259 | Pain, Crushing | 1 | CTD_human |
Hgene | PLCB1 | C0751407 | Pain, Migratory | 1 | CTD_human |
Hgene | PLCB1 | C0751408 | Suffering, Physical | 1 | CTD_human |
Hgene | PLCB1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Hgene | PLCB1 | C2713368 | Hematopoetic Myelodysplasia | 1 | CTD_human |
Hgene | PLCB1 | C3150988 | EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 12 | 1 | CTD_human;GENOMICS_ENGLAND |
Hgene | PLCB1 | C3463824 | MYELODYSPLASTIC SYNDROME | 1 | CTD_human |