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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASTN2-MFF (FusionGDB2 ID:HG23245TG56947)

Fusion Gene Summary for ASTN2-MFF

check button Fusion gene summary
Fusion gene informationFusion gene name: ASTN2-MFF
Fusion gene ID: hg23245tg56947
HgeneTgene
Gene symbol

ASTN2

MFF

Gene ID

23245

56947

Gene nameastrotactin 2mitochondrial fission factor
SynonymsbA67K19.1C2orf33|EMPF2|GL004
Cytomap('ASTN2')('MFF')

9q33.1

2q36.3

Type of geneprotein-codingprotein-coding
Descriptionastrotactin-2mitochondrial fission factor
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000288520, ENST00000313400, 
ENST00000341734, ENST00000358637, 
ENST00000361209, ENST00000361477, 
ENST00000373996, 
Fusion gene scores* DoF score16 X 19 X 6=18246 X 9 X 4=216
# samples 199
** MAII scorelog2(19/1824*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASTN2 [Title/Abstract] AND MFF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASTN2(120032703)-MFF(228221882), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMFF

GO:0090141

positive regulation of mitochondrial fission

23283981|23530241

TgeneMFF

GO:0090314

positive regulation of protein targeting to membrane

23283981



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AEC561706ASTN2chr9

120032703

-MFFchr2

228221882

-


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Fusion Gene ORF analysis for ASTN2-MFF

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000288520ENST00000304593ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000288520ENST00000337110ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000288520ENST00000349901ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000288520ENST00000353339ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000288520ENST00000354503ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000288520ENST00000392059ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000288520ENST00000409565ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000288520ENST00000476924ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000313400ENST00000304593ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000313400ENST00000337110ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000313400ENST00000349901ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000313400ENST00000353339ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000313400ENST00000354503ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000313400ENST00000392059ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000313400ENST00000409565ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000313400ENST00000476924ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000341734ENST00000304593ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000341734ENST00000337110ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000341734ENST00000349901ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000341734ENST00000353339ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000341734ENST00000354503ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000341734ENST00000392059ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000341734ENST00000409565ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000341734ENST00000476924ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000358637ENST00000304593ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000358637ENST00000337110ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000358637ENST00000349901ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000358637ENST00000353339ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000358637ENST00000354503ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000358637ENST00000392059ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000358637ENST00000409565ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000358637ENST00000476924ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000361209ENST00000304593ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000361209ENST00000337110ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000361209ENST00000349901ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000361209ENST00000353339ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000361209ENST00000354503ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000361209ENST00000392059ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000361209ENST00000409565ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000361209ENST00000476924ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000361477ENST00000304593ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000361477ENST00000337110ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000361477ENST00000349901ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000361477ENST00000353339ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000361477ENST00000354503ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000361477ENST00000392059ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000361477ENST00000409565ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000361477ENST00000476924ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000373996ENST00000304593ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000373996ENST00000337110ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000373996ENST00000349901ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000373996ENST00000353339ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000373996ENST00000354503ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000373996ENST00000392059ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000373996ENST00000409565ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-3UTRENST00000373996ENST00000476924ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-intronENST00000288520ENST00000409616ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-intronENST00000288520ENST00000524634ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-intronENST00000313400ENST00000409616ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-intronENST00000313400ENST00000524634ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-intronENST00000341734ENST00000409616ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-intronENST00000341734ENST00000524634ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-intronENST00000358637ENST00000409616ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-intronENST00000358637ENST00000524634ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-intronENST00000361209ENST00000409616ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-intronENST00000361209ENST00000524634ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-intronENST00000361477ENST00000409616ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-intronENST00000361477ENST00000524634ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-intronENST00000373996ENST00000409616ASTN2chr9

120032703

-MFFchr2

228221882

-
intron-intronENST00000373996ENST00000524634ASTN2chr9

120032703

-MFFchr2

228221882

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ASTN2-MFF


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ASTN2-MFF


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:120032703/:228221882)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ASTN2-MFF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ASTN2-MFF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASTN2-MFF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASTN2-MFF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneASTN2C0036341Schizophrenia2PSYGENET
HgeneASTN2C0004352Autistic Disorder1CTD_human
HgeneASTN2C0005586Bipolar Disorder1PSYGENET
HgeneASTN2C0029410Osteoarthritis of hip1CTD_human
HgeneASTN2C0236733Amphetamine-Related Disorders1CTD_human
HgeneASTN2C0236804Amphetamine Addiction1CTD_human
HgeneASTN2C0236807Amphetamine Abuse1CTD_human
HgeneASTN2C0338480Common Migraine1CTD_human
TgeneC4310726ENCEPHALOPATHY DUE TO DEFECTIVE MITOCHONDRIAL AND PEROXISOMAL FISSION 23CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0027051Myocardial Infarction1CTD_human
TgeneC0242698Ventricular Dysfunction, Left1CTD_human