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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FOSB-FN1 (FusionGDB2 ID:HG2354TG2335)

Fusion Gene Summary for FOSB-FN1

Fusion gene summary

Fusion gene information	Fusion gene name: FOSB-FN1
	Fusion gene ID: hg2354tg2335
		Hgene	Tgene
	Gene symbol	FOSB	FN1
	Gene ID	2354	2335
	Gene name	FosB proto-oncogene, AP-1 transcription factor subunit	fibronectin 1
	Synonyms	AP-1\|G0S3\|GOS3\|GOSB	CIG\|ED-B\|FINC\|FN\|FNZ\|GFND\|GFND2\|LETS\|MSF\|SMDCF
	Cytomap	('FOSB')('FN1') 19q13.32	2q35
	Type of gene	protein-coding	protein-coding
	Description	protein fosBFBJ murine osteosarcoma viral oncogene homolog BFosB proto-oncogene, AP-1 trancription factor subunitG0/G1 switch regulatory protein 3activator protein 1	fibronectincold-insoluble globulinepididymis secretory sperm binding proteinmigration-stimulating factor
	Modification date	20200313	20200329
	UniProtAcc	.	P02751
	Ensembl transtripts involved in fusion gene	ENST00000353609, ENST00000417353, ENST00000443841, ENST00000585836, ENST00000586615, ENST00000591858, ENST00000592436, ENST00000592811, ENST00000590335,
Fusion gene scores	* DoF score	3 X 3 X 2=18	35 X 39 X 9=12285
	# samples	3	42
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(42/12285*10)=-4.8703647195834 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FOSB [Title/Abstract] AND FN1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FOSB(45975895)-FN1(216273026), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	FN1	GO:0001932	regulation of protein phosphorylation	11792823
Tgene	FN1	GO:0008284	positive regulation of cell proliferation	25834989
Tgene	FN1	GO:0010628	positive regulation of gene expression	25834989
Tgene	FN1	GO:0018149	peptide cross-linking	3997886
Tgene	FN1	GO:0034446	substrate adhesion-dependent cell spreading	16236823
Tgene	FN1	GO:0035987	endodermal cell differentiation	23154389
Tgene	FN1	GO:0048146	positive regulation of fibroblast proliferation	25834989
Tgene	FN1	GO:0051702	interaction with symbiont	12167537\|12421310\|19429745
Tgene	FN1	GO:0070372	regulation of ERK1 and ERK2 cascade	11792823
Tgene	FN1	GO:1901166	neural crest cell migration involved in autonomic nervous system development	26571399
Tgene	FN1	GO:1904237	positive regulation of substrate-dependent cell migration, cell attachment to substrate	25834989
Tgene	FN1	GO:2001202	negative regulation of transforming growth factor-beta secretion	25834989

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BF809968	FOSB	chr19	45975895	+	FN1	chr2	216273026	+

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Fusion Gene ORF analysis for FOSB-FN1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000353609	ENST00000323926	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000336916	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000345488	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000346544	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000354785	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000356005	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000357009	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000357867	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000359671	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000421182	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000426059	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000432072	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000443816	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000446046	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000490833	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000323926	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000336916	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000345488	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000346544	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000354785	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000356005	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000357009	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000357867	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000359671	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000421182	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000426059	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000432072	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000443816	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000446046	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000490833	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000323926	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000336916	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000345488	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000346544	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000354785	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000356005	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000357009	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000357867	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000359671	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000421182	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000426059	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000432072	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000443816	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000446046	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000490833	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000323926	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000336916	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000345488	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000346544	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000354785	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000356005	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000357009	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000357867	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000359671	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000421182	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000426059	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000432072	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000443816	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000446046	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000490833	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000323926	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000336916	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000345488	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000346544	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000354785	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000356005	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000357009	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000357867	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000359671	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000421182	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000426059	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000432072	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000443816	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000446046	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000490833	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000323926	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000336916	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000345488	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000346544	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000354785	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000356005	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000357009	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000357867	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000359671	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000421182	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000426059	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000432072	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000443816	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000446046	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000490833	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000323926	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000336916	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000345488	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000346544	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000354785	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000356005	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000357009	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000357867	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000359671	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000421182	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000426059	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000432072	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000443816	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000446046	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000490833	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000323926	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000336916	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000345488	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000346544	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000354785	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000356005	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000357009	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000357867	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000359671	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000421182	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000426059	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000432072	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000443816	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000446046	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000490833	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000323926	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000336916	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000345488	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000346544	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000354785	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000356005	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000357009	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000357867	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000359671	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000421182	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000426059	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000432072	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000443816	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000446046	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000490833	FOSB	chr19	45975895	+	FN1	chr2	216273026	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for FOSB-FN1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

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Fusion Protein Features for FOSB-FN1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:45975895/:216273026)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	FN1 P02751
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation (PubMed:34089617). {ECO:0000250\|UniProtKB:P11276, ECO:0000269\|PubMed:3024962, ECO:0000269\|PubMed:34089617, ECO:0000269\|PubMed:3593230, ECO:0000269\|PubMed:3900070, ECO:0000269\|PubMed:7989369}.; FUNCTION: [Anastellin]: Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. {ECO:0000269\|PubMed:11209058, ECO:0000269\|PubMed:15665290, ECO:0000269\|PubMed:19379667, ECO:0000269\|PubMed:8114919}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for FOSB-FN1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FOSB-FN1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for FOSB-FN1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	FN1	P02751	DB08888	Ocriplasmin	Cleavage	Biotech	Approved
Tgene	FN1	P02751	DB08888	Ocriplasmin	Cleavage	Biotech	Approved
Tgene	FN1	P02751	DB14548	Zinc sulfate, unspecified form	Ligand\|Modulator	Small molecule	Approved\|Experimental
Tgene	FN1	P02751	DB14548	Zinc sulfate, unspecified form	Ligand\|Modulator	Small molecule	Approved\|Experimental
Tgene	FN1	P02751	DB01593	Zinc		Small molecule	Approved\|Investigational
Tgene	FN1	P02751	DB01593	Zinc		Small molecule	Approved\|Investigational
Tgene	FN1	P02751	DB14487	Zinc acetate		Small molecule	Approved\|Investigational
Tgene	FN1	P02751	DB14487	Zinc acetate		Small molecule	Approved\|Investigational
Tgene	FN1	P02751	DB14533	Zinc chloride	Ligand\|Modulator	Small molecule	Approved\|Investigational
Tgene	FN1	P02751	DB14533	Zinc chloride	Ligand\|Modulator	Small molecule	Approved\|Investigational

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Related Diseases for FOSB-FN1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	FOSB	C0009171	Cocaine Abuse	4	CTD_human
Hgene	FOSB	C0236736	Cocaine-Related Disorders	4	CTD_human
Hgene	FOSB	C0600427	Cocaine Dependence	4	CTD_human
Hgene	FOSB	C0009241	Cognition Disorders	1	CTD_human
Hgene	FOSB	C0013386	Dyskinesia, Drug-Induced	1	CTD_human
Hgene	FOSB	C0014544	Epilepsy	1	CTD_human
Hgene	FOSB	C0021122	Disruptive, Impulse Control, and Conduct Disorders	1	CTD_human
Hgene	FOSB	C0021776	Intermittent Explosive Disorder	1	CTD_human
Hgene	FOSB	C0023903	Liver neoplasms	1	CTD_human
Hgene	FOSB	C0024121	Lung Neoplasms	1	CTD_human
Hgene	FOSB	C0026650	Movement Disorders	1	CTD_human
Hgene	FOSB	C0033054	Prenatal Exposure Delayed Effects	1	CTD_human
Hgene	FOSB	C0086237	Epilepsy, Cryptogenic	1	CTD_human
Hgene	FOSB	C0087031	Juvenile-Onset Still Disease	1	CTD_human
Hgene	FOSB	C0236018	Aura	1	CTD_human
Hgene	FOSB	C0242379	Malignant neoplasm of lung	1	CTD_human
Hgene	FOSB	C0266487	Etat Marbre	1	CTD_human
Hgene	FOSB	C0345904	Malignant neoplasm of liver	1	CTD_human
Hgene	FOSB	C0525045	Mood Disorders	1	PSYGENET
Hgene	FOSB	C0751088	Dyskinesia, Medication-Induced	1	CTD_human
Hgene	FOSB	C0751111	Awakening Epilepsy	1	CTD_human
Hgene	FOSB	C2239176	Liver carcinoma	1	CTD_human
Hgene	FOSB	C3495559	Juvenile arthritis	1	CTD_human
Hgene	FOSB	C3714758	Juvenile psoriatic arthritis	1	CTD_human
Hgene	FOSB	C4552091	Polyarthritis, Juvenile, Rheumatoid Factor Negative	1	CTD_human
Hgene	FOSB	C4704862	Polyarthritis, Juvenile, Rheumatoid Factor Positive	1	CTD_human
Tgene		C0020538	Hypertensive disease	2	CTD_human
Tgene		C0432221	Spondylometaphyseal dysplasia, 'corner fracture' type	2	GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0000786	Spontaneous abortion	1	CTD_human
Tgene		C0000822	Abortion, Tubal	1	CTD_human
Tgene		C0003504	Aortic Valve Insufficiency	1	CTD_human
Tgene		C0006142	Malignant neoplasm of breast	1	CTD_human;UNIPROT
Tgene		C0007097	Carcinoma	1	CTD_human
Tgene		C0007621	Neoplastic Cell Transformation	1	CTD_human
Tgene		C0010346	Crohn Disease	1	CTD_human
Tgene		C0011849	Diabetes Mellitus	1	CTD_human
Tgene		C0011881	Diabetic Nephropathy	1	CTD_human
Tgene		C0017636	Glioblastoma	1	CTD_human
Tgene		C0017667	Nodular glomerulosclerosis	1	CTD_human
Tgene		C0017668	Focal glomerulosclerosis	1	CTD_human
Tgene		C0024667	Animal Mammary Neoplasms	1	CTD_human
Tgene		C0024668	Mammary Neoplasms, Experimental	1	CTD_human
Tgene		C0027626	Neoplasm Invasiveness	1	CTD_human
Tgene		C0034069	Pulmonary Fibrosis	1	CTD_human
Tgene		C0041956	Ureteral obstruction	1	CTD_human
Tgene		C0085762	Alcohol abuse	1	PSYGENET
Tgene		C0086432	Hyalinosis, Segmental Glomerular	1	CTD_human
Tgene		C0149721	Left Ventricular Hypertrophy	1	CTD_human
Tgene		C0156147	Crohn's disease of large bowel	1	CTD_human
Tgene		C0205696	Anaplastic carcinoma	1	CTD_human
Tgene		C0205697	Carcinoma, Spindle-Cell	1	CTD_human
Tgene		C0205698	Undifferentiated carcinoma	1	CTD_human
Tgene		C0205699	Carcinomatosis	1	CTD_human
Tgene		C0267380	Crohn's disease of the ileum	1	CTD_human
Tgene		C0334588	Giant Cell Glioblastoma	1	CTD_human
Tgene		C0345967	Malignant mesothelioma	1	CTD_human
Tgene		C0678202	Regional enteritis	1	CTD_human
Tgene		C0678222	Breast Carcinoma	1	CTD_human
Tgene		C0949272	IIeocolitis	1	CTD_human
Tgene		C1257925	Mammary Carcinoma, Animal	1	CTD_human
Tgene		C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene		C1458155	Mammary Neoplasms	1	CTD_human
Tgene		C1621958	Glioblastoma Multiforme	1	CTD_human
Tgene		C1866075	GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder)	1	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C3830362	Early Pregnancy Loss	1	CTD_human
Tgene		C3888104	Glomerulopathy with fibronectin deposits	1	CTD_human;ORPHANET
Tgene		C4552766	Miscarriage	1	CTD_human
Tgene		C4704874	Mammary Carcinoma, Human	1	CTD_human
Tgene		C4721507	Alveolitis, Fibrosing	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:FOSB-FN1 (FusionGDB2 ID:HG2354TG2335)

Fusion Gene Summary for FOSB-FN1

Fusion Gene ORF analysis for FOSB-FN1

Fusion Genomic Features for FOSB-FN1

Fusion Protein Features for FOSB-FN1

Fusion Gene Sequence for FOSB-FN1

Fusion Gene PPI Analysis for FOSB-FN1

Related Drugs for FOSB-FN1

Related Diseases for FOSB-FN1

Fusion Gene Studies
in Kim Lab