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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:G6PD-CSF2RA (FusionGDB2 ID:HG2539TG1438)

Fusion Gene Summary for G6PD-CSF2RA

check button Fusion gene summary
Fusion gene informationFusion gene name: G6PD-CSF2RA
Fusion gene ID: hg2539tg1438
HgeneTgene
Gene symbol

G6PD

CSF2RA

Gene ID

2539

1438

Gene nameglucose-6-phosphate dehydrogenasecolony stimulating factor 2 receptor subunit alpha
SynonymsG6PD1CD116|CDw116|CSF2R|CSF2RAX|CSF2RAY|CSF2RX|CSF2RY|GM-CSF-R-alpha|GMCSFR|GMCSFR-alpha|GMR|GMR-alpha|SMDP4|alphaGMR
Cytomap('G6PD')('CSF2RA')

Xq28

Xp22.33 and Yp11.2

Type of geneprotein-codingprotein-coding
Descriptionglucose-6-phosphate 1-dehydrogenaseepididymis secretory sperm binding proteingranulocyte-macrophage colony-stimulating factor receptor subunit alphaCD116 antigenGM-CSF receptor alpha subunitalpha-GM-CSF receptorcolony stimulating factor 2 receptor alpha subunitcolony stimulating factor 2 receptor, alpha, low-affinity (granulo
Modification date2020031320200326
UniProtAcc

P11413

.
Ensembl transtripts involved in fusion geneENST00000369620, ENST00000393562, 
ENST00000393564, ENST00000497281, 
Fusion gene scores* DoF score8 X 11 X 4=3528 X 9 X 3=216
# samples 128
** MAII scorelog2(12/352*10)=-1.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/216*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: G6PD [Title/Abstract] AND CSF2RA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointG6PD(153774251)-CSF2RA(1372816), # samples:1
Anticipated loss of major functional domain due to fusion event.G6PD-CSF2RA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
G6PD-CSF2RA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
G6PD-CSF2RA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
G6PD-CSF2RA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
G6PD-CSF2RA seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
G6PD-CSF2RA seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
G6PD-CSF2RA seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneG6PD

GO:0006098

pentose-phosphate shunt

2297768

HgeneG6PD

GO:0006739

NADP metabolic process

15858258

HgeneG6PD

GO:0019322

pentose biosynthetic process

5643703

HgeneG6PD

GO:0051156

glucose 6-phosphate metabolic process

15858258


check buttonFusion gene breakpoints across G6PD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CSF2RA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A8PH-01AG6PDchrX

153774251

-CSF2RAchrY

1372816

+


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Fusion Gene ORF analysis for G6PD-CSF2RA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000369620ENST00000498153G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-3UTRENST00000393562ENST00000498153G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-3UTRENST00000393564ENST00000498153G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000369620ENST00000355432G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000369620ENST00000355805G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000369620ENST00000361536G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000369620ENST00000381500G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000369620ENST00000381509G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000369620ENST00000381524G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000369620ENST00000417535G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000369620ENST00000494969G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000393562ENST00000355432G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000393562ENST00000355805G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000393562ENST00000361536G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000393562ENST00000381500G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000393562ENST00000381509G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000393562ENST00000381524G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000393562ENST00000417535G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000393562ENST00000494969G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000393564ENST00000355432G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000393564ENST00000355805G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000393564ENST00000361536G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000393564ENST00000381500G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000393564ENST00000381509G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000393564ENST00000381524G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000393564ENST00000417535G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5CDS-intronENST00000393564ENST00000494969G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5UTR-3CDSENST00000497281ENST00000381529G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5UTR-3CDSENST00000497281ENST00000432318G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5UTR-3CDSENST00000497281ENST00000501036G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5UTR-3UTRENST00000497281ENST00000498153G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5UTR-intronENST00000497281ENST00000355432G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5UTR-intronENST00000497281ENST00000355805G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5UTR-intronENST00000497281ENST00000361536G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5UTR-intronENST00000497281ENST00000381500G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5UTR-intronENST00000497281ENST00000381509G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5UTR-intronENST00000497281ENST00000381524G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5UTR-intronENST00000497281ENST00000417535G6PDchrX

153774251

-CSF2RAchrY

1372816

+
5UTR-intronENST00000497281ENST00000494969G6PDchrX

153774251

-CSF2RAchrY

1372816

+
Frame-shiftENST00000393562ENST00000381529G6PDchrX

153774251

-CSF2RAchrY

1372816

+
Frame-shiftENST00000393562ENST00000432318G6PDchrX

153774251

-CSF2RAchrY

1372816

+
Frame-shiftENST00000393562ENST00000501036G6PDchrX

153774251

-CSF2RAchrY

1372816

+
In-frameENST00000369620ENST00000381529G6PDchrX

153774251

-CSF2RAchrY

1372816

+
In-frameENST00000369620ENST00000432318G6PDchrX

153774251

-CSF2RAchrY

1372816

+
In-frameENST00000369620ENST00000501036G6PDchrX

153774251

-CSF2RAchrY

1372816

+
In-frameENST00000393564ENST00000381529G6PDchrX

153774251

-CSF2RAchrY

1372816

+
In-frameENST00000393564ENST00000432318G6PDchrX

153774251

-CSF2RAchrY

1372816

+
In-frameENST00000393564ENST00000501036G6PDchrX

153774251

-CSF2RAchrY

1372816

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369620G6PDchrX153774251-ENST00000381529CSF2RAchrY1372816+93323390869371
ENST00000369620G6PDchrX153774251-ENST00000432318CSF2RAchrY1372816+94623390869371
ENST00000369620G6PDchrX153774251-ENST00000501036CSF2RAchrY1372816+94623390869371
ENST00000393564G6PDchrX153774251-ENST00000381529CSF2RAchrY1372816+93323390869371
ENST00000393564G6PDchrX153774251-ENST00000432318CSF2RAchrY1372816+94623390869371
ENST00000393564G6PDchrX153774251-ENST00000501036CSF2RAchrY1372816+94623390869371

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369620ENST00000381529G6PDchrX153774251-CSF2RAchrY1372816+0.429299770.57070017
ENST00000369620ENST00000432318G6PDchrX153774251-CSF2RAchrY1372816+0.464992520.5350075
ENST00000369620ENST00000501036G6PDchrX153774251-CSF2RAchrY1372816+0.464992520.5350075
ENST00000393564ENST00000381529G6PDchrX153774251-CSF2RAchrY1372816+0.429299770.57070017
ENST00000393564ENST00000432318G6PDchrX153774251-CSF2RAchrY1372816+0.464992520.5350075
ENST00000393564ENST00000501036G6PDchrX153774251-CSF2RAchrY1372816+0.464992520.5350075

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Fusion Genomic Features for G6PD-CSF2RA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
G6PDchrX153774250-CSF2RAchrY1372815+0.0001615370.9998385
G6PDchrX153774250-CSF2RAchrY1372815+0.0001615370.9998385

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for G6PD-CSF2RA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:153774251/chrY:1372816)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
G6PD

P11413

.
FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. {ECO:0000269|PubMed:15858258, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:26479991, ECO:0000269|PubMed:743300}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneG6PDchrX:153774251chrY:1372816ENST00000393562-21338_4570546.0Nucleotide bindingNADP 1
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000355432011220_3200378.0DomainFibronectin type-III
TgeneCSF2RAchrX:153774251chrY:1372816ENST0000035580509220_3200400.0DomainFibronectin type-III
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000361536012220_3200485.3333333333333DomainFibronectin type-III
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381500010220_3200381.6666666666667DomainFibronectin type-III
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000501036711220_320182268.0DomainFibronectin type-III
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000355432011306_3100378.0MotifNote=WSXWS motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000355432011355_3630378.0MotifNote=Box 1 motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST0000035580509306_3100400.0MotifNote=WSXWS motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST0000035580509355_3630400.0MotifNote=Box 1 motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000361536012306_3100485.3333333333333MotifNote=WSXWS motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000361536012355_3630485.3333333333333MotifNote=Box 1 motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381500010306_3100381.6666666666667MotifNote=WSXWS motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381500010355_3630381.6666666666667MotifNote=Box 1 motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381509913355_363315411.0MotifNote=Box 1 motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381524913355_363315401.0MotifNote=Box 1 motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381529913355_363315401.0MotifNote=Box 1 motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000417535812355_363349435.0MotifNote=Box 1 motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST000004323181014355_363315401.0MotifNote=Box 1 motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000501036711306_310182268.0MotifNote=WSXWS motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000501036711355_363182268.0MotifNote=Box 1 motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST0000035543201123_3200378.0Topological domainExtracellular
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000355432011347_4000378.0Topological domainCytoplasmic
TgeneCSF2RAchrX:153774251chrY:1372816ENST000003558050923_3200400.0Topological domainExtracellular
TgeneCSF2RAchrX:153774251chrY:1372816ENST0000035580509347_4000400.0Topological domainCytoplasmic
TgeneCSF2RAchrX:153774251chrY:1372816ENST0000036153601223_3200485.3333333333333Topological domainExtracellular
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000361536012347_4000485.3333333333333Topological domainCytoplasmic
TgeneCSF2RAchrX:153774251chrY:1372816ENST0000038150001023_3200381.6666666666667Topological domainExtracellular
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381500010347_4000381.6666666666667Topological domainCytoplasmic
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381509913347_400315411.0Topological domainCytoplasmic
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381524913347_400315401.0Topological domainCytoplasmic
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381529913347_400315401.0Topological domainCytoplasmic
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000417535812347_400349435.0Topological domainCytoplasmic
TgeneCSF2RAchrX:153774251chrY:1372816ENST000004323181014347_400315401.0Topological domainCytoplasmic
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000501036711347_400182268.0Topological domainCytoplasmic
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000355432011321_3460378.0TransmembraneHelical
TgeneCSF2RAchrX:153774251chrY:1372816ENST0000035580509321_3460400.0TransmembraneHelical
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000361536012321_3460485.3333333333333TransmembraneHelical
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381500010321_3460381.6666666666667TransmembraneHelical
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381509913321_346315411.0TransmembraneHelical
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381524913321_346315401.0TransmembraneHelical
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381529913321_346315401.0TransmembraneHelical
TgeneCSF2RAchrX:153774251chrY:1372816ENST000004323181014321_346315401.0TransmembraneHelical
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000501036711321_346182268.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneG6PDchrX:153774251chrY:1372816ENST00000369620-21338_4540562.0Nucleotide bindingNADP 1
HgeneG6PDchrX:153774251chrY:1372816ENST00000369620-213401_40340562.0Nucleotide bindingNADP 2
HgeneG6PDchrX:153774251chrY:1372816ENST00000369620-213421_42340562.0Nucleotide bindingNADP 2
HgeneG6PDchrX:153774251chrY:1372816ENST00000393562-213401_40370546.0Nucleotide bindingNADP 2
HgeneG6PDchrX:153774251chrY:1372816ENST00000393562-213421_42370546.0Nucleotide bindingNADP 2
HgeneG6PDchrX:153774251chrY:1372816ENST00000393564-21338_4540516.0Nucleotide bindingNADP 1
HgeneG6PDchrX:153774251chrY:1372816ENST00000393564-213401_40340516.0Nucleotide bindingNADP 2
HgeneG6PDchrX:153774251chrY:1372816ENST00000393564-213421_42340516.0Nucleotide bindingNADP 2
HgeneG6PDchrX:153774251chrY:1372816ENST00000369620-213201_20540562.0RegionSubstrate binding
HgeneG6PDchrX:153774251chrY:1372816ENST00000393562-213201_20570546.0RegionSubstrate binding
HgeneG6PDchrX:153774251chrY:1372816ENST00000393564-213201_20540516.0RegionSubstrate binding
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381509913220_320315411.0DomainFibronectin type-III
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381524913220_320315401.0DomainFibronectin type-III
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381529913220_320315401.0DomainFibronectin type-III
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000417535812220_320349435.0DomainFibronectin type-III
TgeneCSF2RAchrX:153774251chrY:1372816ENST000004323181014220_320315401.0DomainFibronectin type-III
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381509913306_310315411.0MotifNote=WSXWS motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381524913306_310315401.0MotifNote=WSXWS motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000381529913306_310315401.0MotifNote=WSXWS motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000417535812306_310349435.0MotifNote=WSXWS motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST000004323181014306_310315401.0MotifNote=WSXWS motif
TgeneCSF2RAchrX:153774251chrY:1372816ENST0000038150991323_320315411.0Topological domainExtracellular
TgeneCSF2RAchrX:153774251chrY:1372816ENST0000038152491323_320315401.0Topological domainExtracellular
TgeneCSF2RAchrX:153774251chrY:1372816ENST0000038152991323_320315401.0Topological domainExtracellular
TgeneCSF2RAchrX:153774251chrY:1372816ENST0000041753581223_320349435.0Topological domainExtracellular
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000432318101423_320315401.0Topological domainExtracellular
TgeneCSF2RAchrX:153774251chrY:1372816ENST0000050103671123_320182268.0Topological domainExtracellular
TgeneCSF2RAchrX:153774251chrY:1372816ENST00000417535812321_346349435.0TransmembraneHelical


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Fusion Gene Sequence for G6PD-CSF2RA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>32010_32010_1_G6PD-CSF2RA_G6PD_chrX_153774251_ENST00000369620_CSF2RA_chrY_1372816_ENST00000381529_length(transcript)=933nt_BP=233nt
CGAGAACTCGGGAAGCCGGCGAGAAGTGTGAGGCCGCGGTAGGGCCGCATCCCGCTCCGGAGAGAAGTCTGAGTCCGCCAGGCTCTGCAG
GCCCGCGGAAGCTCGACAGCGTCATGGCAGAGCAGGTGGCCCTGAGCCGGACCCAGGTGTGCGGGATCCTGCGGGAAGAGCTTTTCCAGG
GCGATGCCTTCCATCAGTCGGATACACACATATTCATCATCATGGGTGCATCGGTTCTGACGACGGGAACCTCGGCTCTGTGTACATTTA
TGTGCTCCTAATCGTGGGAACCCTTGTCTGTGGCATCGTCCTCGGCTTCCTCTTTAAAAGGTTCCTTAGGATACAGCGGCTGTTCCCGCC
AGTTCCACAGATCAAAGACAAACTGAATGATAACCATGAGGTGGAAGACGAGATCATCTGGGAGGAATTCACCCCAGAGGAAGGGAAAGG
CTACCGCGAAGAGGTCTTGACCGTGAAGGAAATTACCTGAGACCCAGAGGGTGTAGGAATGGCATGGACATCTCCGCCTCCGCGACACGG
GGGAACTGTTTTCTTGATGATGCTGTGAACCTTTATATCATTTTCTATGTTTTTATTTAAAAACATGACATTTGGGGCCAGGCGCGGTGG
CTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGCCCAACATGGTGA
AACCCCATCTGGACTAAAAATGCAGAAATTTACCCAGGCACGGCGGCGGACGCCCATCATCCCAGCTACTTGGGAGGCTGAGGCAGGAGA
ATTGCTTGAACCCGTGAGGCGGAGGTTGTAGTGAGCCAAGATCGCACCATTGCACACCAACCTGCGTGACAGAGCAAGATTGCATCTCAA

>32010_32010_1_G6PD-CSF2RA_G6PD_chrX_153774251_ENST00000369620_CSF2RA_chrY_1372816_ENST00000381529_length(amino acids)=71AA_BP=1

--------------------------------------------------------------
>32010_32010_2_G6PD-CSF2RA_G6PD_chrX_153774251_ENST00000369620_CSF2RA_chrY_1372816_ENST00000432318_length(transcript)=946nt_BP=233nt
CGAGAACTCGGGAAGCCGGCGAGAAGTGTGAGGCCGCGGTAGGGCCGCATCCCGCTCCGGAGAGAAGTCTGAGTCCGCCAGGCTCTGCAG
GCCCGCGGAAGCTCGACAGCGTCATGGCAGAGCAGGTGGCCCTGAGCCGGACCCAGGTGTGCGGGATCCTGCGGGAAGAGCTTTTCCAGG
GCGATGCCTTCCATCAGTCGGATACACACATATTCATCATCATGGGTGCATCGGTTCTGACGACGGGAACCTCGGCTCTGTGTACATTTA
TGTGCTCCTAATCGTGGGAACCCTTGTCTGTGGCATCGTCCTCGGCTTCCTCTTTAAAAGGTTCCTTAGGATACAGCGGCTGTTCCCGCC
AGTTCCACAGATCAAAGACAAACTGAATGATAACCATGAGGTGGAAGACGAGATCATCTGGGAGGAATTCACCCCAGAGGAAGGGAAAGG
CTACCGCGAAGAGGTCTTGACCGTGAAGGAAATTACCTGAGACCCAGAGGGTGTAGGAATGGCATGGACATCTCCGCCTCCGCGACACGG
GGGAACTGTTTTCTTGATGATGCTGTGAACCTTTATATCATTTTCTATGTTTTTATTTAAAAACATGACATTTGGGGCCAGGCGCGGTGG
CTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGCCCAACATGGTGA
AACCCCATCTGGACTAAAAATGCAGAAATTTACCCAGGCACGGCGGCGGACGCCCATCATCCCAGCTACTTGGGAGGCTGAGGCAGGAGA
ATTGCTTGAACCCGTGAGGCGGAGGTTGTAGTGAGCCAAGATCGCACCATTGCACACCAACCTGCGTGACAGAGCAAGATTGCATCTCAA

>32010_32010_2_G6PD-CSF2RA_G6PD_chrX_153774251_ENST00000369620_CSF2RA_chrY_1372816_ENST00000432318_length(amino acids)=71AA_BP=1

--------------------------------------------------------------
>32010_32010_3_G6PD-CSF2RA_G6PD_chrX_153774251_ENST00000369620_CSF2RA_chrY_1372816_ENST00000501036_length(transcript)=946nt_BP=233nt
CGAGAACTCGGGAAGCCGGCGAGAAGTGTGAGGCCGCGGTAGGGCCGCATCCCGCTCCGGAGAGAAGTCTGAGTCCGCCAGGCTCTGCAG
GCCCGCGGAAGCTCGACAGCGTCATGGCAGAGCAGGTGGCCCTGAGCCGGACCCAGGTGTGCGGGATCCTGCGGGAAGAGCTTTTCCAGG
GCGATGCCTTCCATCAGTCGGATACACACATATTCATCATCATGGGTGCATCGGTTCTGACGACGGGAACCTCGGCTCTGTGTACATTTA
TGTGCTCCTAATCGTGGGAACCCTTGTCTGTGGCATCGTCCTCGGCTTCCTCTTTAAAAGGTTCCTTAGGATACAGCGGCTGTTCCCGCC
AGTTCCACAGATCAAAGACAAACTGAATGATAACCATGAGGTGGAAGACGAGATCATCTGGGAGGAATTCACCCCAGAGGAAGGGAAAGG
CTACCGCGAAGAGGTCTTGACCGTGAAGGAAATTACCTGAGACCCAGAGGGTGTAGGAATGGCATGGACATCTCCGCCTCCGCGACACGG
GGGAACTGTTTTCTTGATGATGCTGTGAACCTTTATATCATTTTCTATGTTTTTATTTAAAAACATGACATTTGGGGCCAGGCGCGGTGG
CTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGCCCAACATGGTGA
AACCCCATCTGGACTAAAAATGCAGAAATTTACCCAGGCACGGCGGCGGACGCCCATCATCCCAGCTACTTGGGAGGCTGAGGCAGGAGA
ATTGCTTGAACCCGTGAGGCGGAGGTTGTAGTGAGCCAAGATCGCACCATTGCACACCAACCTGCGTGACAGAGCAAGATTGCATCTCAA

>32010_32010_3_G6PD-CSF2RA_G6PD_chrX_153774251_ENST00000369620_CSF2RA_chrY_1372816_ENST00000501036_length(amino acids)=71AA_BP=1

--------------------------------------------------------------
>32010_32010_4_G6PD-CSF2RA_G6PD_chrX_153774251_ENST00000393564_CSF2RA_chrY_1372816_ENST00000381529_length(transcript)=933nt_BP=233nt
CGAGAACTCGGGAAGCCGGCGAGAAGTGTGAGGCCGCGGTAGGGCCGCATCCCGCTCCGGAGAGAAGTCTGAGTCCGCCAGGCTCTGCAG
GCCCGCGGAAGCTCGACAGCGTCATGGCAGAGCAGGTGGCCCTGAGCCGGACCCAGGTGTGCGGGATCCTGCGGGAAGAGCTTTTCCAGG
GCGATGCCTTCCATCAGTCGGATACACACATATTCATCATCATGGGTGCATCGGTTCTGACGACGGGAACCTCGGCTCTGTGTACATTTA
TGTGCTCCTAATCGTGGGAACCCTTGTCTGTGGCATCGTCCTCGGCTTCCTCTTTAAAAGGTTCCTTAGGATACAGCGGCTGTTCCCGCC
AGTTCCACAGATCAAAGACAAACTGAATGATAACCATGAGGTGGAAGACGAGATCATCTGGGAGGAATTCACCCCAGAGGAAGGGAAAGG
CTACCGCGAAGAGGTCTTGACCGTGAAGGAAATTACCTGAGACCCAGAGGGTGTAGGAATGGCATGGACATCTCCGCCTCCGCGACACGG
GGGAACTGTTTTCTTGATGATGCTGTGAACCTTTATATCATTTTCTATGTTTTTATTTAAAAACATGACATTTGGGGCCAGGCGCGGTGG
CTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGCCCAACATGGTGA
AACCCCATCTGGACTAAAAATGCAGAAATTTACCCAGGCACGGCGGCGGACGCCCATCATCCCAGCTACTTGGGAGGCTGAGGCAGGAGA
ATTGCTTGAACCCGTGAGGCGGAGGTTGTAGTGAGCCAAGATCGCACCATTGCACACCAACCTGCGTGACAGAGCAAGATTGCATCTCAA

>32010_32010_4_G6PD-CSF2RA_G6PD_chrX_153774251_ENST00000393564_CSF2RA_chrY_1372816_ENST00000381529_length(amino acids)=71AA_BP=1

--------------------------------------------------------------
>32010_32010_5_G6PD-CSF2RA_G6PD_chrX_153774251_ENST00000393564_CSF2RA_chrY_1372816_ENST00000432318_length(transcript)=946nt_BP=233nt
CGAGAACTCGGGAAGCCGGCGAGAAGTGTGAGGCCGCGGTAGGGCCGCATCCCGCTCCGGAGAGAAGTCTGAGTCCGCCAGGCTCTGCAG
GCCCGCGGAAGCTCGACAGCGTCATGGCAGAGCAGGTGGCCCTGAGCCGGACCCAGGTGTGCGGGATCCTGCGGGAAGAGCTTTTCCAGG
GCGATGCCTTCCATCAGTCGGATACACACATATTCATCATCATGGGTGCATCGGTTCTGACGACGGGAACCTCGGCTCTGTGTACATTTA
TGTGCTCCTAATCGTGGGAACCCTTGTCTGTGGCATCGTCCTCGGCTTCCTCTTTAAAAGGTTCCTTAGGATACAGCGGCTGTTCCCGCC
AGTTCCACAGATCAAAGACAAACTGAATGATAACCATGAGGTGGAAGACGAGATCATCTGGGAGGAATTCACCCCAGAGGAAGGGAAAGG
CTACCGCGAAGAGGTCTTGACCGTGAAGGAAATTACCTGAGACCCAGAGGGTGTAGGAATGGCATGGACATCTCCGCCTCCGCGACACGG
GGGAACTGTTTTCTTGATGATGCTGTGAACCTTTATATCATTTTCTATGTTTTTATTTAAAAACATGACATTTGGGGCCAGGCGCGGTGG
CTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGCCCAACATGGTGA
AACCCCATCTGGACTAAAAATGCAGAAATTTACCCAGGCACGGCGGCGGACGCCCATCATCCCAGCTACTTGGGAGGCTGAGGCAGGAGA
ATTGCTTGAACCCGTGAGGCGGAGGTTGTAGTGAGCCAAGATCGCACCATTGCACACCAACCTGCGTGACAGAGCAAGATTGCATCTCAA

>32010_32010_5_G6PD-CSF2RA_G6PD_chrX_153774251_ENST00000393564_CSF2RA_chrY_1372816_ENST00000432318_length(amino acids)=71AA_BP=1

--------------------------------------------------------------
>32010_32010_6_G6PD-CSF2RA_G6PD_chrX_153774251_ENST00000393564_CSF2RA_chrY_1372816_ENST00000501036_length(transcript)=946nt_BP=233nt
CGAGAACTCGGGAAGCCGGCGAGAAGTGTGAGGCCGCGGTAGGGCCGCATCCCGCTCCGGAGAGAAGTCTGAGTCCGCCAGGCTCTGCAG
GCCCGCGGAAGCTCGACAGCGTCATGGCAGAGCAGGTGGCCCTGAGCCGGACCCAGGTGTGCGGGATCCTGCGGGAAGAGCTTTTCCAGG
GCGATGCCTTCCATCAGTCGGATACACACATATTCATCATCATGGGTGCATCGGTTCTGACGACGGGAACCTCGGCTCTGTGTACATTTA
TGTGCTCCTAATCGTGGGAACCCTTGTCTGTGGCATCGTCCTCGGCTTCCTCTTTAAAAGGTTCCTTAGGATACAGCGGCTGTTCCCGCC
AGTTCCACAGATCAAAGACAAACTGAATGATAACCATGAGGTGGAAGACGAGATCATCTGGGAGGAATTCACCCCAGAGGAAGGGAAAGG
CTACCGCGAAGAGGTCTTGACCGTGAAGGAAATTACCTGAGACCCAGAGGGTGTAGGAATGGCATGGACATCTCCGCCTCCGCGACACGG
GGGAACTGTTTTCTTGATGATGCTGTGAACCTTTATATCATTTTCTATGTTTTTATTTAAAAACATGACATTTGGGGCCAGGCGCGGTGG
CTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGCCCAACATGGTGA
AACCCCATCTGGACTAAAAATGCAGAAATTTACCCAGGCACGGCGGCGGACGCCCATCATCCCAGCTACTTGGGAGGCTGAGGCAGGAGA
ATTGCTTGAACCCGTGAGGCGGAGGTTGTAGTGAGCCAAGATCGCACCATTGCACACCAACCTGCGTGACAGAGCAAGATTGCATCTCAA

>32010_32010_6_G6PD-CSF2RA_G6PD_chrX_153774251_ENST00000393564_CSF2RA_chrY_1372816_ENST00000501036_length(amino acids)=71AA_BP=1

--------------------------------------------------------------

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Fusion Gene PPI Analysis for G6PD-CSF2RA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for G6PD-CSF2RA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneG6PDP11413DB03085Glycolic acidInhibitorSmall moleculeApproved|Investigational

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Related Diseases for G6PD-CSF2RA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneG6PDC2720289ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY21CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneG6PDC0005586Bipolar Disorder5PSYGENET
HgeneG6PDC0002878Anemia, Hemolytic4CTD_human;GENOMICS_ENGLAND
HgeneG6PDC0002879Anemia, Hemolytic, Acquired3CTD_human
HgeneG6PDC0002889Anemia, Microangiopathic3CTD_human
HgeneG6PDC0022660Kidney Failure, Acute3CTD_human
HgeneG6PDC0221021Microangiopathic hemolytic anemia3CTD_human
HgeneG6PDC1565662Acute Kidney Insufficiency3CTD_human
HgeneG6PDC2609414Acute kidney injury3CTD_human
HgeneG6PDC2939465Deficiency of glucose-6-phosphate dehydrogenase3CTD_human
HgeneG6PDC0002882Anemia, Hemolytic, Congenital Nonspherocytic2CTD_human
HgeneG6PDC0015702Favism2CTD_human
HgeneG6PDC0019054Hemolysis (disorder)2CTD_human
HgeneG6PDC0235574Intravascular hemolysis2CTD_human
HgeneG6PDC0312854Extravascular Hemolysis2CTD_human
HgeneG6PDC0520572Enzymopathy2GENOMICS_ENGLAND
HgeneG6PDC0011616Contact Dermatitis1CTD_human
HgeneG6PDC0018203Chronic granulomatous disease1CTD_human
HgeneG6PDC0031306Phagocyte Bactericidal Dysfunction1CTD_human
HgeneG6PDC0162351Contact hypersensitivity1CTD_human
HgeneG6PDC1844376Granulomatous Disease, Chronic, X-Linked1CTD_human
HgeneG6PDC3661525Autosomal Recessive Chronic Granulomatous Disease1CTD_human
HgeneG6PDC3714514Infection1GENOMICS_ENGLAND
TgeneC2677877Surfactant Metabolism Dysfunction, Pulmonary, 44CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0034050Pulmonary Alveolar Proteinosis3CTD_human;GENOMICS_ENGLAND
TgeneC0036341Schizophrenia2PSYGENET
TgeneC2931035Pulmonary alveolar proteinosis, congenital2GENOMICS_ENGLAND;ORPHANET
TgeneC0020517Hypersensitivity1GENOMICS_ENGLAND