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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRPC4AP-PPFIA1 (FusionGDB2 ID:HG26133TG8500)

Fusion Gene Summary for TRPC4AP-PPFIA1

check button Fusion gene summary
Fusion gene informationFusion gene name: TRPC4AP-PPFIA1
Fusion gene ID: hg26133tg8500
HgeneTgene
Gene symbol

TRPC4AP

PPFIA1

Gene ID

26133

8500

Gene nametransient receptor potential cation channel subfamily C member 4 associated proteinPTPRF interacting protein alpha 1
SynonymsC20orf188|PPP1R158|TRRP4AP|TRUSSLIP.1|LIP1|LIPRIN
Cytomap('TRPC4AP')('PPFIA1')

20q11.22

11q13.3

Type of geneprotein-codingprotein-coding
Descriptionshort transient receptor potential channel 4-associated proteinTNF-receptor ubiquitous scaffolding/signaling proteinTRP4-associated proteinprotein phosphatase 1, regulatory subunit 158trpc4-associated proteintumor necrosis factor receptor-associated liprin-alpha-1LAR-interacting protein 1LIP-1Liprin-alpha1protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000252015, ENST00000451813, 
ENST00000432634, ENST00000539834, 
Fusion gene scores* DoF score30 X 25 X 10=750019 X 19 X 10=3610
# samples 3324
** MAII scorelog2(33/7500*10)=-4.50635266602479
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/3610*10)=-3.91089252616601
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRPC4AP [Title/Abstract] AND PPFIA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRPC4AP(33657099)-PPFIA1(70118279), # samples:2
Anticipated loss of major functional domain due to fusion event.TRPC4AP-PPFIA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRPC4AP-PPFIA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRPC4AP-PPFIA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TRPC4AP-PPFIA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRPC4AP

GO:0006511

ubiquitin-dependent protein catabolic process

20551172

HgeneTRPC4AP

GO:0016567

protein ubiquitination

20551172


check buttonFusion gene breakpoints across TRPC4AP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PPFIA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A079-01ATRPC4APchr20

33657099

-PPFIA1chr11

70118279

+


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Fusion Gene ORF analysis for TRPC4AP-PPFIA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000252015ENST00000530548TRPC4APchr20

33657099

-PPFIA1chr11

70118279

+
5CDS-intronENST00000451813ENST00000530548TRPC4APchr20

33657099

-PPFIA1chr11

70118279

+
In-frameENST00000252015ENST00000253925TRPC4APchr20

33657099

-PPFIA1chr11

70118279

+
In-frameENST00000252015ENST00000389547TRPC4APchr20

33657099

-PPFIA1chr11

70118279

+
In-frameENST00000451813ENST00000253925TRPC4APchr20

33657099

-PPFIA1chr11

70118279

+
In-frameENST00000451813ENST00000389547TRPC4APchr20

33657099

-PPFIA1chr11

70118279

+
intron-3CDSENST00000432634ENST00000253925TRPC4APchr20

33657099

-PPFIA1chr11

70118279

+
intron-3CDSENST00000432634ENST00000389547TRPC4APchr20

33657099

-PPFIA1chr11

70118279

+
intron-3CDSENST00000539834ENST00000253925TRPC4APchr20

33657099

-PPFIA1chr11

70118279

+
intron-3CDSENST00000539834ENST00000389547TRPC4APchr20

33657099

-PPFIA1chr11

70118279

+
intron-intronENST00000432634ENST00000530548TRPC4APchr20

33657099

-PPFIA1chr11

70118279

+
intron-intronENST00000539834ENST00000530548TRPC4APchr20

33657099

-PPFIA1chr11

70118279

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000451813TRPC4APchr2033657099-ENST00000253925PPFIA1chr1170118279+5459440540481347
ENST00000451813TRPC4APchr2033657099-ENST00000389547PPFIA1chr1170118279+4375440539971330
ENST00000252015TRPC4APchr2033657099-ENST00000253925PPFIA1chr1170118279+55235046941121347
ENST00000252015TRPC4APchr2033657099-ENST00000389547PPFIA1chr1170118279+44395046940611330

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000451813ENST00000253925TRPC4APchr2033657099-PPFIA1chr1170118279+0.0002201280.9997799
ENST00000451813ENST00000389547TRPC4APchr2033657099-PPFIA1chr1170118279+0.0008727350.9991273
ENST00000252015ENST00000253925TRPC4APchr2033657099-PPFIA1chr1170118279+0.0002432660.99975675
ENST00000252015ENST00000389547TRPC4APchr2033657099-PPFIA1chr1170118279+0.0009821710.99901783

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Fusion Genomic Features for TRPC4AP-PPFIA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TRPC4APchr2033657098-PPFIA1chr1170118278+1.19E-091
TRPC4APchr2033657098-PPFIA1chr1170118278+1.19E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TRPC4AP-PPFIA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:33657099/chr11:70118279)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePPFIA1chr20:33657099chr11:70118279ENST000002539250281021_105001597.3333333333333Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr20:33657099chr11:70118279ENST00000253925028176_21401597.3333333333333Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr20:33657099chr11:70118279ENST00000253925028249_52101597.3333333333333Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr20:33657099chr11:70118279ENST0000025392502834_14101597.3333333333333Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr20:33657099chr11:70118279ENST00000253925028623_66901597.3333333333333Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr20:33657099chr11:70118279ENST00000253925028847_87101597.3333333333333Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr20:33657099chr11:70118279ENST000003895470261021_105001186.0Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr20:33657099chr11:70118279ENST00000389547026176_21401186.0Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr20:33657099chr11:70118279ENST00000389547026249_52101186.0Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr20:33657099chr11:70118279ENST0000038954702634_14101186.0Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr20:33657099chr11:70118279ENST00000389547026623_66901186.0Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr20:33657099chr11:70118279ENST00000389547026847_87101186.0Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr20:33657099chr11:70118279ENST0000025392502817_2501597.3333333333333Compositional biasNote=Poly-Gly
TgenePPFIA1chr20:33657099chr11:70118279ENST0000038954702617_2501186.0Compositional biasNote=Poly-Gly
TgenePPFIA1chr20:33657099chr11:70118279ENST000002539250281051_112001597.3333333333333DomainSAM 3
TgenePPFIA1chr20:33657099chr11:70118279ENST00000253925028878_94401597.3333333333333DomainSAM 1
TgenePPFIA1chr20:33657099chr11:70118279ENST00000253925028963_102701597.3333333333333DomainSAM 2
TgenePPFIA1chr20:33657099chr11:70118279ENST000003895470261051_112001186.0DomainSAM 3
TgenePPFIA1chr20:33657099chr11:70118279ENST00000389547026878_94401186.0DomainSAM 1
TgenePPFIA1chr20:33657099chr11:70118279ENST00000389547026963_102701186.0DomainSAM 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TRPC4AP-PPFIA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94358_94358_1_TRPC4AP-PPFIA1_TRPC4AP_chr20_33657099_ENST00000252015_PPFIA1_chr11_70118279_ENST00000253925_length(transcript)=5523nt_BP=504nt
ACTGGGGGCGCTGCGGCGACCCCTCCGCCGCCCCGTAGAAATCTCCGCGGCCCCGAGGCCGCTTGCTTCCTGTTTGTCCGACGAGGAGAC
ATGGCGGCGGCGCCGGTAGCGGCTGGGTCTGGAGCCGGCCGAGGGAGACGGTCGGCAGCCACAGTGGCGGCTTGGGGCGGATGGGGCGGC
CGGCCGCGGCCTGGTAACATTCTGCTGCAGCTGCGGCAGGGCCAGCTGACCGGCCGGGGCCTGGTCCGGGCGGTGCAGTTCACTGAGACT
TTTTTGACGGAGAGGGACAAACAATCCAAGTGGAGTGGAATTCCTCAGCTGCTCCTCAAGCTGCACACCACCAGCCACCTCCACAGTGAC
TTTGTTGAGTGTCAAAACATCCTCAAGGAAATTTCTCCTCTTCTCTCCATGGAGGCTATGGCATTTGTTACTGAAGAGAGGAAACTTACC
CAAGAAACCACTTATCCAAATACTTACATTTTTGACTTGTTTGGAGGTGTTGATATGATGTGCGAGGTGATGCCGACCATCAGCGAAGCA
GAAGGCCCCCCTGGAGGAGGTGGAGGCCATGGTTCCGGCTCCCCTTCACAGCCAGATGCAGATTCACATTTTGAACAGTTGATGGTCTCC
ATGCTAGAAGAAAGGGACCGCCTTCTTGATACACTGAGAGAGACTCAAGAAACGCTGGCCTTAACCCAGGGGAAGTTACACGAGGTTGGT
CATGAAAGAGATTCCTTGCAGAGACAGCTCAACACGGCACTTCCACAGGAGTTCGCAGCACTTACTAAAGAACTCAATGTATGCAGGGAA
CAGCTCCTTGAAAGGGAAGAAGAAATTGCTGAACTGAAAGCAGAAAGGAATAACACCAGGCTGCTGTTAGAGCATTTGGAATGCCTTGTC
TCCAGGCATGAGCGGTCTCTTAGGATGACCGTGGTGAAGAGACAAGCGCAGTCTCCAGCAGGCGTGTCCAGCGAAGTGGAAGTGCTGAAA
GCACTGAAGTCCTTATTTGAACACCACAAAGCTCTGGATGAAAAGGTGAGAGAGCGATTACGAGTAGCACTTGAAAGATGTAGTTTGTTA
GAAGAGGAATTAGGTGCCACACACAAAGAGCTAATGATTCTTAAAGAACAGAATAATCAGAAAAAAACTCTAACAGATGGAGTGCTGGAC
ATAAACCATGAACAAGAAAATACACCAAGCACGAGTGGAAAGAGATCTTCTGATGGTTCTTTAAGCCACGAGGAAGACCTTGCTAAAGTA
ATTGAGCTCCAAGAAATCATAAGTAAGCAGTCAAGGGAACAGAGCCAAATGAAAGAACGCCTGGCTTCCCTTTCCAGTCATGTGACAGAA
CTGGAAGAGGATCTGGACACGGCTAGAAAAGATCTCATCAAATCTGAAGAAATGAACACAAAATTGCAACGAGATGTCCGTGAAGCCATG
GCCCAAAAGGAAGATATGGAAGAGAGAATCACTACTCTTGAAAAACGCTACCTCGCTGCACAGCGTGAAGCCACATCTGTGCATGACCTC
AATGATAAACTTGAAAATGAAATTGCAAATAAAGATTCTATGCATCGACAGACTGAAGATAAAAACCGCCAGTTACAGGAGCGCTTGGAA
TTGGCAGAGCAAAAGCTGCAACAGACACTGAGGAAGGCAGAGACGCTCCCGGAGGTGGAGGCGGAGCTGGCCCAGAGGGTGGCAGCGCTT
TCCAAGGCTGAAGAGAGACACGGCAACATTGAAGAAAGGTTACGACAGATGGAAGCACAGTTGGAGGAGAAGAATCAAGAACTGCAGCGG
GCAAGGCAAAGAGAAAAAATGAACGAAGAACATAATAAACGTTTATCAGACACTGTTGACAAGCTGCTTTCAGAATCTAATGAGAGGCTT
CAACTTCATCTTAAAGAGAGAATGGCTGCTTTGGAAGATAAGAACTCTCTTTTAAGAGAAGTTGAAAGTGCAAAAAAGCAGTTAGAAGAA
ACACAACACGATAAGGATCAGCTTGTCCTAAACATTGAAGCACTGAGGGCTGAACTAGACCACATGAGACTAAGAGGTGCTTCACTTCAT
CATGGCCGACCCCACTTGGGCAGTGTCCCAGATTTCAGGTTCCCCATGGCAGACGGCCACACAGACTCCTACAGCACCAGTGCAGTGCTG
CGGCGCCCACAGAAAGGCCGGCTGGCAGCCCTGCGAGATGAGCCTTCCAAGGTACAAACTCTTAATGAGCAGGATTGGGAACGTGCCCAG
CAAGCTAGTGTCTTGGCAAATGTAGCACAAGCATTCGAGAGTGATGCTGACGTGTCTGATGGTGAAGATGACAGGGACACTCTCCTCAGC
TCAGTTGACCTGCTATCGCCCAGCGGGCAGGCCGACGCGCACACACTAGCCATGATGCTTCAGGAGCAGCTGGACGCCATCAACAAAGAG
ATCAGGTTGATTCAGGAAGAAAAAGAAAATACAGAGCAGCGGGCAGAGGAGATTGAAAGTCGAGTTGGCAGTGGAAGTCTAGACAATCTT
GGTCGTTTTAGATCAATGAGCTCCATTCCCCCCTACCCTGCTTCCTCGCTTGCTAGCTCCTCCCCTCCGGGCAGTGGGCGCTCCACCCCA
CGAAGGATCCCTCACAGCCCAGCTCGGGAAGTGGACAGACTGGGCGTCATGACCCTTTTGCCACCTTCCAGAGAAGAGGTACGAGATGAC
AAGACAACCATAAAGTGTGAAACCTCCCCGCCTTCCTCCCCGAGAGCCCTTCGGTTAGACCGGCTGCACAAAGGGGCGCTGCACACCGTC
AGCCACGAGGACATCAGGGACATAAGGAACTCCACAGGCTCCCAGGATGGTCCCGTGAGCAACCCCAGCAGTAGCAACAGTAGCCAGGAC
TCGCTCCACAAAGCCCCAAAGAAGAAAGGCATTAAGTCCTCCATTGGCCGCTTGTTTGGCAAGAAAGAAAAGGGCCGACCTGGACAAACT
GGCAAAGAAGCATTAGGACAAGCTGGTGTTTCCGAGACGGATAACTCATCTCAGGATGCCTTGGGACTTAGCAAATTGGGGGGACAGGCT
GAAAAAAATCGTAAACTTCAAAAAAAGCATGAATTGCTGGAGGAAGCCCGGAGACAAGGTTTACCTTTTGCCCAATGGGACGGGCCAACG
GTTGTGGTCTGGCTAGAGCTCTGGGTTGGGATGCCAGCCTGGTATGTGGCTGCCTGCCGAGCAAACGTGAAAAGCGGGGCCATCATGTCG
GCCCTGTCCGACACAGAGATCCAGCGTGAGATTGGCATCAGCAACCCCCTGCACAGGCTGAAGCTGAGGCTGGCCATCCAGGAGATCATG
TCGCTGACCAGCCCGTCTGCCCCGCCCACATCTAGAACGACACTCGCCTATGGGGACATGAACCACGAGTGGATCGGCAACGAGTGGCTC
CCCAGCCTGGGCCTCCCCCAGTACCGCAGCTACTTCATGGAGTGCCTTGTAGACGCCAGGATGCTGGACCACTTGACCAAGAAAGACCTT
CGAGGGCAGCTGAAAATGGTCGACAGTTTTCACAGAAACAGTTTCCAGTGTGGAATTATGTGCCTGAGAAGGTTAAATTATGACCGGAAA
GAACTGGAAAGAAAAAGAGAAGAAAGTCAGAGTGAAATAAAAGACGTGCTTGTTTGGAGCAATGATCGAGTGATTCGCTGGATCCTGTCA
ATTGGCCTTAAAGAATATGCAAACAATCTTATAGAGAGTGGTGTTCACGGAGCACTTCTGGCCTTAGATGAAACCTTCGACTTCAGTGCA
CTGGCACTGCTGTTACAGATCCCGACGCAGAACACACAGGCTCGTGCTGTCTTGGAAAGAGAATTTAACAACCTTTTGGTCATGGGGACT
GATAGAAGGTTTGATGAAGATGATGATAAAAGCTTTAGGAGAGCACCTTCATGGAGAAAAAAGTTTAGACCAAAGGACATTCGTGGCTTA
GCTGCTGGGTCAGCAGAGACTCTCCCTGCAAACTTCCGGGTGACTTCTTCTATGTCTTCCCCCTCTATGCAGCCAAAGAAGATGCAGATG
GACGGCAATGTATCAGGAACACAGAGGTTGGATTCTGCTACAGTCAGGACTTACTCCTGCTAAAGTCTCCTGTTGTTTACCCACACTACT
TCTACAGATGATTATGCAGCATTTGAATCCAACAAAGACTACATTTTGGAATCCAGTGGAATCTTTAATCTTGTTAATACTTGTTATATG
GACCCTAAGATATTTTATTACAGAGTTTTTAATTAGTGAAAAATTCATGAATACCATAGAGAAAATATTTTAGAATTTAATGTTTCTTAT
ATTTATGTAAACTTATGACTCTTCATTTATATAGTTACTTACTTTTTCATGTATATCCAGGCTATAAATATCCTTTCAAATCATGTTCTT
ATACCTAATTTTAGTCTTTCAAATGAATGTACTGTAATGCTTGTATGTATAAATCCTATGAATAGAGGGCTTTTGTAAATTATGCATTTA
TTGTAATTATCATTAATTTTTTAATGATAAACCATGACAAAGGATTTTACGTTTATAAAATTATGACAGAAGCCATGTGCATTATCCTTT
ACGGACGCAGCCTAGCTCTACAGCAATCATCCTGAAATAAGCATACCTAATTTCAAGCAATTGTTGTATTTTCATGACTGACCTTAACTG
TACTTTTTCTAGCAAGAGATGCTTTATTCTGCAGCATGAACAGATTTAAAATGGCTGGTGTTAAATATCAGCTCCTAATAAGATGTGGAC
TGAAAACACTATCACAACACTATGAGAAGCCCCTAGCACTGGTTAACGCTTTCCTAGCCTAGTCTCTGGATTTGGGGAGCTTGTCTTCAG
TGGCTGAGACTGTGAGCTGGGAGCAGTTCTCTCAGCTGGAGAGACTCGGGATGGGGTAACCTGGGGACCAGTCTAGCCCCTGCACCCTCT
TCCCTGCCTCTGCTCCTTGGGAGCGGGTGGAGAGACACCCATGTGGCTCCCCTTAGGGCCAGCACCAAGCACCACGCTCTCATCCTGCAA
GTCGGCGCACACAGTGGATGAAGGCAGGAGACCCAGAAAGCAGTGCAGTGCAGCTCTAATAAAGGCCTTATTTTTCTTATGTAAATCATC
TTTTTACATTTGTTTGTAAACATGTTTAAAGAACGAACCTAGTGGGACATTTTTAGACTTTGATGCTCTAGCCATTTTGGATTGTGTAAG
TTGCAGATGTGGCTTTTACTTTTTAAATGGCATATTAACAAGCCAGCAAAGTGTGTCAGACCATGGCGTGGTATTTATTGTGCAGCAGAT
CCAGAGACAGAGGCAGCCTGTCTTTTCAGTTGGTTTCTGCTTTTAATTTACTTGTACAATTCATTGTTACTGTTCTGTTTTTCTATTAAT
CTTTTGTCAACTTCCTGATTATGTAACAAAGTATGTACAGTCTACTTTTGAACTATTTTTATCACAGTATTATTTATTGCTTTCTTTCAA

>94358_94358_1_TRPC4AP-PPFIA1_TRPC4AP_chr20_33657099_ENST00000252015_PPFIA1_chr11_70118279_ENST00000253925_length(amino acids)=1347AA_BP=145
MFVRRGDMAAAPVAAGSGAGRGRRSAATVAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKQSKWSGIPQLLLKLHT
TSHLHSDFVECQNILKEISPLLSMEAMAFVTEERKLTQETTYPNTYIFDLFGGVDMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSH
FEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLL
EHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKT
LTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQ
RDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAEL
AQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVES
AKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNE
QDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVG
SGSLDNLGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREEVRDDKTTIKCETSPPSSPRALRLDRLH
KGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQDALGL
SKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLR
LAIQEIMSLTSPSAPPTSRTTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLR
RLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFN

--------------------------------------------------------------
>94358_94358_2_TRPC4AP-PPFIA1_TRPC4AP_chr20_33657099_ENST00000252015_PPFIA1_chr11_70118279_ENST00000389547_length(transcript)=4439nt_BP=504nt
ACTGGGGGCGCTGCGGCGACCCCTCCGCCGCCCCGTAGAAATCTCCGCGGCCCCGAGGCCGCTTGCTTCCTGTTTGTCCGACGAGGAGAC
ATGGCGGCGGCGCCGGTAGCGGCTGGGTCTGGAGCCGGCCGAGGGAGACGGTCGGCAGCCACAGTGGCGGCTTGGGGCGGATGGGGCGGC
CGGCCGCGGCCTGGTAACATTCTGCTGCAGCTGCGGCAGGGCCAGCTGACCGGCCGGGGCCTGGTCCGGGCGGTGCAGTTCACTGAGACT
TTTTTGACGGAGAGGGACAAACAATCCAAGTGGAGTGGAATTCCTCAGCTGCTCCTCAAGCTGCACACCACCAGCCACCTCCACAGTGAC
TTTGTTGAGTGTCAAAACATCCTCAAGGAAATTTCTCCTCTTCTCTCCATGGAGGCTATGGCATTTGTTACTGAAGAGAGGAAACTTACC
CAAGAAACCACTTATCCAAATACTTACATTTTTGACTTGTTTGGAGGTGTTGATATGATGTGCGAGGTGATGCCGACCATCAGCGAAGCA
GAAGGCCCCCCTGGAGGAGGTGGAGGCCATGGTTCCGGCTCCCCTTCACAGCCAGATGCAGATTCACATTTTGAACAGTTGATGGTCTCC
ATGCTAGAAGAAAGGGACCGCCTTCTTGATACACTGAGAGAGACTCAAGAAACGCTGGCCTTAACCCAGGGGAAGTTACACGAGGTTGGT
CATGAAAGAGATTCCTTGCAGAGACAGCTCAACACGGCACTTCCACAGGAGTTCGCAGCACTTACTAAAGAACTCAATGTATGCAGGGAA
CAGCTCCTTGAAAGGGAAGAAGAAATTGCTGAACTGAAAGCAGAAAGGAATAACACCAGGCTGCTGTTAGAGCATTTGGAATGCCTTGTC
TCCAGGCATGAGCGGTCTCTTAGGATGACCGTGGTGAAGAGACAAGCGCAGTCTCCAGCAGGCGTGTCCAGCGAAGTGGAAGTGCTGAAA
GCACTGAAGTCCTTATTTGAACACCACAAAGCTCTGGATGAAAAGGTGAGAGAGCGATTACGAGTAGCACTTGAAAGATGTAGTTTGTTA
GAAGAGGAATTAGGTGCCACACACAAAGAGCTAATGATTCTTAAAGAACAGAATAATCAGAAAAAAACTCTAACAGATGGAGTGCTGGAC
ATAAACCATGAACAAGAAAATACACCAAGCACGAGTGGAAAGAGATCTTCTGATGGTTCTTTAAGCCACGAGGAAGACCTTGCTAAAGTA
ATTGAGCTCCAAGAAATCATAAGTAAGCAGTCAAGGGAACAGAGCCAAATGAAAGAACGCCTGGCTTCCCTTTCCAGTCATGTGACAGAA
CTGGAAGAGGATCTGGACACGGCTAGAAAAGATCTCATCAAATCTGAAGAAATGAACACAAAATTGCAACGAGATGTCCGTGAAGCCATG
GCCCAAAAGGAAGATATGGAAGAGAGAATCACTACTCTTGAAAAACGCTACCTCGCTGCACAGCGTGAAGCCACATCTGTGCATGACCTC
AATGATAAACTTGAAAATGAAATTGCAAATAAAGATTCTATGCATCGACAGACTGAAGATAAAAACCGCCAGTTACAGGAGCGCTTGGAA
TTGGCAGAGCAAAAGCTGCAACAGACACTGAGGAAGGCAGAGACGCTCCCGGAGGTGGAGGCGGAGCTGGCCCAGAGGGTGGCAGCGCTT
TCCAAGGCTGAAGAGAGACACGGCAACATTGAAGAAAGGTTACGACAGATGGAAGCACAGTTGGAGGAGAAGAATCAAGAACTGCAGCGG
GCAAGGCAAAGAGAAAAAATGAACGAAGAACATAATAAACGTTTATCAGACACTGTTGACAAGCTGCTTTCAGAATCTAATGAGAGGCTT
CAACTTCATCTTAAAGAGAGAATGGCTGCTTTGGAAGATAAGAACTCTCTTTTAAGAGAAGTTGAAAGTGCAAAAAAGCAGTTAGAAGAA
ACACAACACGATAAGGATCAGCTTGTCCTAAACATTGAAGCACTGAGGGCTGAACTAGACCACATGAGACTAAGAGGTGCTTCACTTCAT
CATGGCCGACCCCACTTGGGCAGTGTCCCAGATTTCAGGTTCCCCATGGCAGACGGCCACACAGACTCCTACAGCACCAGTGCAGTGCTG
CGGCGCCCACAGAAAGGCCGGCTGGCAGCCCTGCGAGATGAGCCTTCCAAGGTACAAACTCTTAATGAGCAGGATTGGGAACGTGCCCAG
CAAGCTAGTGTCTTGGCAAATGTAGCACAAGCATTCGAGAGTGATGCTGACGTGTCTGATGGTGAAGATGACAGGGACACTCTCCTCAGC
TCAGTTGACCTGCTATCGCCCAGCGGGCAGGCCGACGCGCACACACTAGCCATGATGCTTCAGGAGCAGCTGGACGCCATCAACAAAGAG
ATCAGGTTGATTCAGGAAGAAAAAGAAAATACAGAGCAGCGGGCAGAGGAGATTGAAAGTCGAGTTGGCAGTGGAAGTCTAGACAATCTT
GGTCGTTTTAGATCAATGAGCTCCATTCCCCCCTACCCTGCTTCCTCGCTTGCTAGCTCCTCCCCTCCGGGCAGTGGGCGCTCCACCCCA
CGAAGGATCCCTCACAGCCCAGCTCGGGAAGTGGACAGACTGGGCGTCATGACCCTTTTGCCACCTTCCAGAGAAGAGGTACGAGATGAC
AAGACAACCATAAAGTGTGAAACCTCCCCGCCTTCCTCCCCGAGAGCCCTTCGGTTAGACCGGCTGCACAAAGGGGCGCTGCACACCGTC
AGCCACGAGGACATCAGGGACATAAGGAACTCCACAGGCTCCCAGGATGGTCCCGTGAGCAACCCCAGCAGTAGCAACAGTAGCCAGGAC
TCGCTCCACAAAGCCCCAAAGAAGAAAGGCATTAAGTCCTCCATTGGCCGCTTGTTTGGCAAGAAAGAAAAGGGCCGACCTGGACAAACT
GGCAAAGAAGCATTAGGACAAGCTGGTGTTTCCGAGACGGATAACTCATCTCAGGATGCCTTGGGACTTAGCAAATTGGGGGGACAGGCT
GAAAAAAATCGTAAACTTCAAAAAAAGCATGAATTGCTGGAGGAAGCCCGGAGACAAGGTTTACCTTTTGCCCAATGGGACGGGCCAACG
GTTGTGGTCTGGCTAGAGCTCTGGGTTGGGATGCCAGCCTGGTATGTGGCTGCCTGCCGAGCAAACGTGAAAAGCGGGGCCATCATGTCG
GCCCTGTCCGACACAGAGATCCAGCGTGAGATTGGCATCAGCAACCCCCTGCACAGGCTGAAGCTGAGGCTGGCCATCCAGGAGATCATG
TCGCTGACCAGCCCGTCTGCCCCGCCCACATCTAGAACGACACTCGCCTATGGGGACATGAACCACGAGTGGATCGGCAACGAGTGGCTC
CCCAGCCTGGGCCTCCCCCAGTACCGCAGCTACTTCATGGAGTGCCTTGTAGACGCCAGGATGCTGGACCACTTGACCAAGAAAGACCTT
CGAGGGCAGCTGAAAATGGTCGACAGTTTTCACAGAAACAGTTTCCAGTGTGGAATTATGTGCCTGAGAAGGTTAAATTATGACCGGAAA
GAACTGGAAAGAAAAAGAGAAGAAAGTCAGAGTGAAATAAAAGACGTGCTTGTTTGGAGCAATGATCGAGTGATTCGCTGGATCCTGTCA
ATTGGCCTTAAAGAATATGCAAACAATCTTATAGAGAGTGGTGTTCACGGAGCACTTCTGGCCTTAGATGAAACCTTCGACTTCAGTGCA
CTGGCACTGCTGTTACAGATCCCGACGCAGAACACACAGGCTCGTGCTGTCTTGGAAAGAGAATTTAACAACCTTTTGGTCATGGGGACT
GATAGAAGGTTTGATGAAGATGATGATAAAAGCTTTAGGAGAGCACCTTCATGGAGAAAAAAGTTTAGACCAAAGGACATTCGTGGCTTA
GCTGCTGGGTCAGCAGAGACTCTCCCTGCAAACTTCCGGGTGACTTCTTCTATGTCTTCCCCCTCTATGCAGCCAAAGAAGATGCAGATG
GACGGTATGTGATGGGTCACACTAACCTGTCACTTGTTGGGAGCATGAGCAGCTTTCTGTCTGGAACATTAATAATGATCTAAAACGGCC
TATTTAATATGTTACAAGGCACTTGAGTATGGTTGCATGTCCAAATATAAATGTTTTTAAATTAACTCTAACATTTGTTTATAAAAGTTT
AACCATAATAATAGAATTTTTAAAACACGCTTGTCTGGTTGAATCTTAGCATATTTTTCCAACTAATAAAGCTCAGTATTCGTCTGTGTT
CTCAGAGAGAGACTGAGGCATACTTGTAAATTTGTGTCTGTGACAGGCCGTGCTAGAAAGCTCTTTCAGGAAATAGTAGTGTAGTAGTAG

>94358_94358_2_TRPC4AP-PPFIA1_TRPC4AP_chr20_33657099_ENST00000252015_PPFIA1_chr11_70118279_ENST00000389547_length(amino acids)=1330AA_BP=145
MFVRRGDMAAAPVAAGSGAGRGRRSAATVAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKQSKWSGIPQLLLKLHT
TSHLHSDFVECQNILKEISPLLSMEAMAFVTEERKLTQETTYPNTYIFDLFGGVDMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSH
FEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLL
EHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKT
LTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQ
RDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAEL
AQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVES
AKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNE
QDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVG
SGSLDNLGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREEVRDDKTTIKCETSPPSSPRALRLDRLH
KGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQDALGL
SKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLR
LAIQEIMSLTSPSAPPTSRTTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLR
RLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFN

--------------------------------------------------------------
>94358_94358_3_TRPC4AP-PPFIA1_TRPC4AP_chr20_33657099_ENST00000451813_PPFIA1_chr11_70118279_ENST00000253925_length(transcript)=5459nt_BP=440nt
GCTTCCTGTTTGTCCGACGAGGAGACATGGCGGCGGCGCCGGTAGCGGCTGGGTCTGGAGCCGGCCGAGGGAGACGGTCGGCAGCCACAG
TGGCGGCTTGGGGCGGATGGGGCGGCCGGCCGCGGCCTGGTAACATTCTGCTGCAGCTGCGGCAGGGCCAGCTGACCGGCCGGGGCCTGG
TCCGGGCGGTGCAGTTCACTGAGACTTTTTTGACGGAGAGGGACAAACAATCCAAGTGGAGTGGAATTCCTCAGCTGCTCCTCAAGCTGC
ACACCACCAGCCACCTCCACAGTGACTTTGTTGAGTGTCAAAACATCCTCAAGGAAATTTCTCCTCTTCTCTCCATGGAGGCTATGGCAT
TTGTTACTGAAGAGAGGAAACTTACCCAAGAAACCACTTATCCAAATACTTACATTTTTGACTTGTTTGGAGGTGTTGATATGATGTGCG
AGGTGATGCCGACCATCAGCGAAGCAGAAGGCCCCCCTGGAGGAGGTGGAGGCCATGGTTCCGGCTCCCCTTCACAGCCAGATGCAGATT
CACATTTTGAACAGTTGATGGTCTCCATGCTAGAAGAAAGGGACCGCCTTCTTGATACACTGAGAGAGACTCAAGAAACGCTGGCCTTAA
CCCAGGGGAAGTTACACGAGGTTGGTCATGAAAGAGATTCCTTGCAGAGACAGCTCAACACGGCACTTCCACAGGAGTTCGCAGCACTTA
CTAAAGAACTCAATGTATGCAGGGAACAGCTCCTTGAAAGGGAAGAAGAAATTGCTGAACTGAAAGCAGAAAGGAATAACACCAGGCTGC
TGTTAGAGCATTTGGAATGCCTTGTCTCCAGGCATGAGCGGTCTCTTAGGATGACCGTGGTGAAGAGACAAGCGCAGTCTCCAGCAGGCG
TGTCCAGCGAAGTGGAAGTGCTGAAAGCACTGAAGTCCTTATTTGAACACCACAAAGCTCTGGATGAAAAGGTGAGAGAGCGATTACGAG
TAGCACTTGAAAGATGTAGTTTGTTAGAAGAGGAATTAGGTGCCACACACAAAGAGCTAATGATTCTTAAAGAACAGAATAATCAGAAAA
AAACTCTAACAGATGGAGTGCTGGACATAAACCATGAACAAGAAAATACACCAAGCACGAGTGGAAAGAGATCTTCTGATGGTTCTTTAA
GCCACGAGGAAGACCTTGCTAAAGTAATTGAGCTCCAAGAAATCATAAGTAAGCAGTCAAGGGAACAGAGCCAAATGAAAGAACGCCTGG
CTTCCCTTTCCAGTCATGTGACAGAACTGGAAGAGGATCTGGACACGGCTAGAAAAGATCTCATCAAATCTGAAGAAATGAACACAAAAT
TGCAACGAGATGTCCGTGAAGCCATGGCCCAAAAGGAAGATATGGAAGAGAGAATCACTACTCTTGAAAAACGCTACCTCGCTGCACAGC
GTGAAGCCACATCTGTGCATGACCTCAATGATAAACTTGAAAATGAAATTGCAAATAAAGATTCTATGCATCGACAGACTGAAGATAAAA
ACCGCCAGTTACAGGAGCGCTTGGAATTGGCAGAGCAAAAGCTGCAACAGACACTGAGGAAGGCAGAGACGCTCCCGGAGGTGGAGGCGG
AGCTGGCCCAGAGGGTGGCAGCGCTTTCCAAGGCTGAAGAGAGACACGGCAACATTGAAGAAAGGTTACGACAGATGGAAGCACAGTTGG
AGGAGAAGAATCAAGAACTGCAGCGGGCAAGGCAAAGAGAAAAAATGAACGAAGAACATAATAAACGTTTATCAGACACTGTTGACAAGC
TGCTTTCAGAATCTAATGAGAGGCTTCAACTTCATCTTAAAGAGAGAATGGCTGCTTTGGAAGATAAGAACTCTCTTTTAAGAGAAGTTG
AAAGTGCAAAAAAGCAGTTAGAAGAAACACAACACGATAAGGATCAGCTTGTCCTAAACATTGAAGCACTGAGGGCTGAACTAGACCACA
TGAGACTAAGAGGTGCTTCACTTCATCATGGCCGACCCCACTTGGGCAGTGTCCCAGATTTCAGGTTCCCCATGGCAGACGGCCACACAG
ACTCCTACAGCACCAGTGCAGTGCTGCGGCGCCCACAGAAAGGCCGGCTGGCAGCCCTGCGAGATGAGCCTTCCAAGGTACAAACTCTTA
ATGAGCAGGATTGGGAACGTGCCCAGCAAGCTAGTGTCTTGGCAAATGTAGCACAAGCATTCGAGAGTGATGCTGACGTGTCTGATGGTG
AAGATGACAGGGACACTCTCCTCAGCTCAGTTGACCTGCTATCGCCCAGCGGGCAGGCCGACGCGCACACACTAGCCATGATGCTTCAGG
AGCAGCTGGACGCCATCAACAAAGAGATCAGGTTGATTCAGGAAGAAAAAGAAAATACAGAGCAGCGGGCAGAGGAGATTGAAAGTCGAG
TTGGCAGTGGAAGTCTAGACAATCTTGGTCGTTTTAGATCAATGAGCTCCATTCCCCCCTACCCTGCTTCCTCGCTTGCTAGCTCCTCCC
CTCCGGGCAGTGGGCGCTCCACCCCACGAAGGATCCCTCACAGCCCAGCTCGGGAAGTGGACAGACTGGGCGTCATGACCCTTTTGCCAC
CTTCCAGAGAAGAGGTACGAGATGACAAGACAACCATAAAGTGTGAAACCTCCCCGCCTTCCTCCCCGAGAGCCCTTCGGTTAGACCGGC
TGCACAAAGGGGCGCTGCACACCGTCAGCCACGAGGACATCAGGGACATAAGGAACTCCACAGGCTCCCAGGATGGTCCCGTGAGCAACC
CCAGCAGTAGCAACAGTAGCCAGGACTCGCTCCACAAAGCCCCAAAGAAGAAAGGCATTAAGTCCTCCATTGGCCGCTTGTTTGGCAAGA
AAGAAAAGGGCCGACCTGGACAAACTGGCAAAGAAGCATTAGGACAAGCTGGTGTTTCCGAGACGGATAACTCATCTCAGGATGCCTTGG
GACTTAGCAAATTGGGGGGACAGGCTGAAAAAAATCGTAAACTTCAAAAAAAGCATGAATTGCTGGAGGAAGCCCGGAGACAAGGTTTAC
CTTTTGCCCAATGGGACGGGCCAACGGTTGTGGTCTGGCTAGAGCTCTGGGTTGGGATGCCAGCCTGGTATGTGGCTGCCTGCCGAGCAA
ACGTGAAAAGCGGGGCCATCATGTCGGCCCTGTCCGACACAGAGATCCAGCGTGAGATTGGCATCAGCAACCCCCTGCACAGGCTGAAGC
TGAGGCTGGCCATCCAGGAGATCATGTCGCTGACCAGCCCGTCTGCCCCGCCCACATCTAGAACGACACTCGCCTATGGGGACATGAACC
ACGAGTGGATCGGCAACGAGTGGCTCCCCAGCCTGGGCCTCCCCCAGTACCGCAGCTACTTCATGGAGTGCCTTGTAGACGCCAGGATGC
TGGACCACTTGACCAAGAAAGACCTTCGAGGGCAGCTGAAAATGGTCGACAGTTTTCACAGAAACAGTTTCCAGTGTGGAATTATGTGCC
TGAGAAGGTTAAATTATGACCGGAAAGAACTGGAAAGAAAAAGAGAAGAAAGTCAGAGTGAAATAAAAGACGTGCTTGTTTGGAGCAATG
ATCGAGTGATTCGCTGGATCCTGTCAATTGGCCTTAAAGAATATGCAAACAATCTTATAGAGAGTGGTGTTCACGGAGCACTTCTGGCCT
TAGATGAAACCTTCGACTTCAGTGCACTGGCACTGCTGTTACAGATCCCGACGCAGAACACACAGGCTCGTGCTGTCTTGGAAAGAGAAT
TTAACAACCTTTTGGTCATGGGGACTGATAGAAGGTTTGATGAAGATGATGATAAAAGCTTTAGGAGAGCACCTTCATGGAGAAAAAAGT
TTAGACCAAAGGACATTCGTGGCTTAGCTGCTGGGTCAGCAGAGACTCTCCCTGCAAACTTCCGGGTGACTTCTTCTATGTCTTCCCCCT
CTATGCAGCCAAAGAAGATGCAGATGGACGGCAATGTATCAGGAACACAGAGGTTGGATTCTGCTACAGTCAGGACTTACTCCTGCTAAA
GTCTCCTGTTGTTTACCCACACTACTTCTACAGATGATTATGCAGCATTTGAATCCAACAAAGACTACATTTTGGAATCCAGTGGAATCT
TTAATCTTGTTAATACTTGTTATATGGACCCTAAGATATTTTATTACAGAGTTTTTAATTAGTGAAAAATTCATGAATACCATAGAGAAA
ATATTTTAGAATTTAATGTTTCTTATATTTATGTAAACTTATGACTCTTCATTTATATAGTTACTTACTTTTTCATGTATATCCAGGCTA
TAAATATCCTTTCAAATCATGTTCTTATACCTAATTTTAGTCTTTCAAATGAATGTACTGTAATGCTTGTATGTATAAATCCTATGAATA
GAGGGCTTTTGTAAATTATGCATTTATTGTAATTATCATTAATTTTTTAATGATAAACCATGACAAAGGATTTTACGTTTATAAAATTAT
GACAGAAGCCATGTGCATTATCCTTTACGGACGCAGCCTAGCTCTACAGCAATCATCCTGAAATAAGCATACCTAATTTCAAGCAATTGT
TGTATTTTCATGACTGACCTTAACTGTACTTTTTCTAGCAAGAGATGCTTTATTCTGCAGCATGAACAGATTTAAAATGGCTGGTGTTAA
ATATCAGCTCCTAATAAGATGTGGACTGAAAACACTATCACAACACTATGAGAAGCCCCTAGCACTGGTTAACGCTTTCCTAGCCTAGTC
TCTGGATTTGGGGAGCTTGTCTTCAGTGGCTGAGACTGTGAGCTGGGAGCAGTTCTCTCAGCTGGAGAGACTCGGGATGGGGTAACCTGG
GGACCAGTCTAGCCCCTGCACCCTCTTCCCTGCCTCTGCTCCTTGGGAGCGGGTGGAGAGACACCCATGTGGCTCCCCTTAGGGCCAGCA
CCAAGCACCACGCTCTCATCCTGCAAGTCGGCGCACACAGTGGATGAAGGCAGGAGACCCAGAAAGCAGTGCAGTGCAGCTCTAATAAAG
GCCTTATTTTTCTTATGTAAATCATCTTTTTACATTTGTTTGTAAACATGTTTAAAGAACGAACCTAGTGGGACATTTTTAGACTTTGAT
GCTCTAGCCATTTTGGATTGTGTAAGTTGCAGATGTGGCTTTTACTTTTTAAATGGCATATTAACAAGCCAGCAAAGTGTGTCAGACCAT
GGCGTGGTATTTATTGTGCAGCAGATCCAGAGACAGAGGCAGCCTGTCTTTTCAGTTGGTTTCTGCTTTTAATTTACTTGTACAATTCAT
TGTTACTGTTCTGTTTTTCTATTAATCTTTTGTCAACTTCCTGATTATGTAACAAAGTATGTACAGTCTACTTTTGAACTATTTTTATCA

>94358_94358_3_TRPC4AP-PPFIA1_TRPC4AP_chr20_33657099_ENST00000451813_PPFIA1_chr11_70118279_ENST00000253925_length(amino acids)=1347AA_BP=145
MFVRRGDMAAAPVAAGSGAGRGRRSAATVAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKQSKWSGIPQLLLKLHT
TSHLHSDFVECQNILKEISPLLSMEAMAFVTEERKLTQETTYPNTYIFDLFGGVDMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSH
FEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLL
EHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKT
LTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQ
RDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAEL
AQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVES
AKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNE
QDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVG
SGSLDNLGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREEVRDDKTTIKCETSPPSSPRALRLDRLH
KGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQDALGL
SKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLR
LAIQEIMSLTSPSAPPTSRTTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLR
RLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFN

--------------------------------------------------------------
>94358_94358_4_TRPC4AP-PPFIA1_TRPC4AP_chr20_33657099_ENST00000451813_PPFIA1_chr11_70118279_ENST00000389547_length(transcript)=4375nt_BP=440nt
GCTTCCTGTTTGTCCGACGAGGAGACATGGCGGCGGCGCCGGTAGCGGCTGGGTCTGGAGCCGGCCGAGGGAGACGGTCGGCAGCCACAG
TGGCGGCTTGGGGCGGATGGGGCGGCCGGCCGCGGCCTGGTAACATTCTGCTGCAGCTGCGGCAGGGCCAGCTGACCGGCCGGGGCCTGG
TCCGGGCGGTGCAGTTCACTGAGACTTTTTTGACGGAGAGGGACAAACAATCCAAGTGGAGTGGAATTCCTCAGCTGCTCCTCAAGCTGC
ACACCACCAGCCACCTCCACAGTGACTTTGTTGAGTGTCAAAACATCCTCAAGGAAATTTCTCCTCTTCTCTCCATGGAGGCTATGGCAT
TTGTTACTGAAGAGAGGAAACTTACCCAAGAAACCACTTATCCAAATACTTACATTTTTGACTTGTTTGGAGGTGTTGATATGATGTGCG
AGGTGATGCCGACCATCAGCGAAGCAGAAGGCCCCCCTGGAGGAGGTGGAGGCCATGGTTCCGGCTCCCCTTCACAGCCAGATGCAGATT
CACATTTTGAACAGTTGATGGTCTCCATGCTAGAAGAAAGGGACCGCCTTCTTGATACACTGAGAGAGACTCAAGAAACGCTGGCCTTAA
CCCAGGGGAAGTTACACGAGGTTGGTCATGAAAGAGATTCCTTGCAGAGACAGCTCAACACGGCACTTCCACAGGAGTTCGCAGCACTTA
CTAAAGAACTCAATGTATGCAGGGAACAGCTCCTTGAAAGGGAAGAAGAAATTGCTGAACTGAAAGCAGAAAGGAATAACACCAGGCTGC
TGTTAGAGCATTTGGAATGCCTTGTCTCCAGGCATGAGCGGTCTCTTAGGATGACCGTGGTGAAGAGACAAGCGCAGTCTCCAGCAGGCG
TGTCCAGCGAAGTGGAAGTGCTGAAAGCACTGAAGTCCTTATTTGAACACCACAAAGCTCTGGATGAAAAGGTGAGAGAGCGATTACGAG
TAGCACTTGAAAGATGTAGTTTGTTAGAAGAGGAATTAGGTGCCACACACAAAGAGCTAATGATTCTTAAAGAACAGAATAATCAGAAAA
AAACTCTAACAGATGGAGTGCTGGACATAAACCATGAACAAGAAAATACACCAAGCACGAGTGGAAAGAGATCTTCTGATGGTTCTTTAA
GCCACGAGGAAGACCTTGCTAAAGTAATTGAGCTCCAAGAAATCATAAGTAAGCAGTCAAGGGAACAGAGCCAAATGAAAGAACGCCTGG
CTTCCCTTTCCAGTCATGTGACAGAACTGGAAGAGGATCTGGACACGGCTAGAAAAGATCTCATCAAATCTGAAGAAATGAACACAAAAT
TGCAACGAGATGTCCGTGAAGCCATGGCCCAAAAGGAAGATATGGAAGAGAGAATCACTACTCTTGAAAAACGCTACCTCGCTGCACAGC
GTGAAGCCACATCTGTGCATGACCTCAATGATAAACTTGAAAATGAAATTGCAAATAAAGATTCTATGCATCGACAGACTGAAGATAAAA
ACCGCCAGTTACAGGAGCGCTTGGAATTGGCAGAGCAAAAGCTGCAACAGACACTGAGGAAGGCAGAGACGCTCCCGGAGGTGGAGGCGG
AGCTGGCCCAGAGGGTGGCAGCGCTTTCCAAGGCTGAAGAGAGACACGGCAACATTGAAGAAAGGTTACGACAGATGGAAGCACAGTTGG
AGGAGAAGAATCAAGAACTGCAGCGGGCAAGGCAAAGAGAAAAAATGAACGAAGAACATAATAAACGTTTATCAGACACTGTTGACAAGC
TGCTTTCAGAATCTAATGAGAGGCTTCAACTTCATCTTAAAGAGAGAATGGCTGCTTTGGAAGATAAGAACTCTCTTTTAAGAGAAGTTG
AAAGTGCAAAAAAGCAGTTAGAAGAAACACAACACGATAAGGATCAGCTTGTCCTAAACATTGAAGCACTGAGGGCTGAACTAGACCACA
TGAGACTAAGAGGTGCTTCACTTCATCATGGCCGACCCCACTTGGGCAGTGTCCCAGATTTCAGGTTCCCCATGGCAGACGGCCACACAG
ACTCCTACAGCACCAGTGCAGTGCTGCGGCGCCCACAGAAAGGCCGGCTGGCAGCCCTGCGAGATGAGCCTTCCAAGGTACAAACTCTTA
ATGAGCAGGATTGGGAACGTGCCCAGCAAGCTAGTGTCTTGGCAAATGTAGCACAAGCATTCGAGAGTGATGCTGACGTGTCTGATGGTG
AAGATGACAGGGACACTCTCCTCAGCTCAGTTGACCTGCTATCGCCCAGCGGGCAGGCCGACGCGCACACACTAGCCATGATGCTTCAGG
AGCAGCTGGACGCCATCAACAAAGAGATCAGGTTGATTCAGGAAGAAAAAGAAAATACAGAGCAGCGGGCAGAGGAGATTGAAAGTCGAG
TTGGCAGTGGAAGTCTAGACAATCTTGGTCGTTTTAGATCAATGAGCTCCATTCCCCCCTACCCTGCTTCCTCGCTTGCTAGCTCCTCCC
CTCCGGGCAGTGGGCGCTCCACCCCACGAAGGATCCCTCACAGCCCAGCTCGGGAAGTGGACAGACTGGGCGTCATGACCCTTTTGCCAC
CTTCCAGAGAAGAGGTACGAGATGACAAGACAACCATAAAGTGTGAAACCTCCCCGCCTTCCTCCCCGAGAGCCCTTCGGTTAGACCGGC
TGCACAAAGGGGCGCTGCACACCGTCAGCCACGAGGACATCAGGGACATAAGGAACTCCACAGGCTCCCAGGATGGTCCCGTGAGCAACC
CCAGCAGTAGCAACAGTAGCCAGGACTCGCTCCACAAAGCCCCAAAGAAGAAAGGCATTAAGTCCTCCATTGGCCGCTTGTTTGGCAAGA
AAGAAAAGGGCCGACCTGGACAAACTGGCAAAGAAGCATTAGGACAAGCTGGTGTTTCCGAGACGGATAACTCATCTCAGGATGCCTTGG
GACTTAGCAAATTGGGGGGACAGGCTGAAAAAAATCGTAAACTTCAAAAAAAGCATGAATTGCTGGAGGAAGCCCGGAGACAAGGTTTAC
CTTTTGCCCAATGGGACGGGCCAACGGTTGTGGTCTGGCTAGAGCTCTGGGTTGGGATGCCAGCCTGGTATGTGGCTGCCTGCCGAGCAA
ACGTGAAAAGCGGGGCCATCATGTCGGCCCTGTCCGACACAGAGATCCAGCGTGAGATTGGCATCAGCAACCCCCTGCACAGGCTGAAGC
TGAGGCTGGCCATCCAGGAGATCATGTCGCTGACCAGCCCGTCTGCCCCGCCCACATCTAGAACGACACTCGCCTATGGGGACATGAACC
ACGAGTGGATCGGCAACGAGTGGCTCCCCAGCCTGGGCCTCCCCCAGTACCGCAGCTACTTCATGGAGTGCCTTGTAGACGCCAGGATGC
TGGACCACTTGACCAAGAAAGACCTTCGAGGGCAGCTGAAAATGGTCGACAGTTTTCACAGAAACAGTTTCCAGTGTGGAATTATGTGCC
TGAGAAGGTTAAATTATGACCGGAAAGAACTGGAAAGAAAAAGAGAAGAAAGTCAGAGTGAAATAAAAGACGTGCTTGTTTGGAGCAATG
ATCGAGTGATTCGCTGGATCCTGTCAATTGGCCTTAAAGAATATGCAAACAATCTTATAGAGAGTGGTGTTCACGGAGCACTTCTGGCCT
TAGATGAAACCTTCGACTTCAGTGCACTGGCACTGCTGTTACAGATCCCGACGCAGAACACACAGGCTCGTGCTGTCTTGGAAAGAGAAT
TTAACAACCTTTTGGTCATGGGGACTGATAGAAGGTTTGATGAAGATGATGATAAAAGCTTTAGGAGAGCACCTTCATGGAGAAAAAAGT
TTAGACCAAAGGACATTCGTGGCTTAGCTGCTGGGTCAGCAGAGACTCTCCCTGCAAACTTCCGGGTGACTTCTTCTATGTCTTCCCCCT
CTATGCAGCCAAAGAAGATGCAGATGGACGGTATGTGATGGGTCACACTAACCTGTCACTTGTTGGGAGCATGAGCAGCTTTCTGTCTGG
AACATTAATAATGATCTAAAACGGCCTATTTAATATGTTACAAGGCACTTGAGTATGGTTGCATGTCCAAATATAAATGTTTTTAAATTA
ACTCTAACATTTGTTTATAAAAGTTTAACCATAATAATAGAATTTTTAAAACACGCTTGTCTGGTTGAATCTTAGCATATTTTTCCAACT
AATAAAGCTCAGTATTCGTCTGTGTTCTCAGAGAGAGACTGAGGCATACTTGTAAATTTGTGTCTGTGACAGGCCGTGCTAGAAAGCTCT

>94358_94358_4_TRPC4AP-PPFIA1_TRPC4AP_chr20_33657099_ENST00000451813_PPFIA1_chr11_70118279_ENST00000389547_length(amino acids)=1330AA_BP=145
MFVRRGDMAAAPVAAGSGAGRGRRSAATVAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKQSKWSGIPQLLLKLHT
TSHLHSDFVECQNILKEISPLLSMEAMAFVTEERKLTQETTYPNTYIFDLFGGVDMMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSH
FEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLL
EHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKT
LTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQ
RDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAEL
AQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVES
AKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNE
QDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVG
SGSLDNLGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREEVRDDKTTIKCETSPPSSPRALRLDRLH
KGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQDALGL
SKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLR
LAIQEIMSLTSPSAPPTSRTTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLR
RLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFN

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Fusion Gene PPI Analysis for TRPC4AP-PPFIA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTRPC4APchr20:33657099chr11:70118279ENST00000252015-3192_400138.0798.0TNFRSF1A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRPC4AP-PPFIA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRPC4AP-PPFIA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource