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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HIBCH-INPP1 (FusionGDB2 ID:HG26275TG3628)

Fusion Gene Summary for HIBCH-INPP1

check button Fusion gene summary
Fusion gene informationFusion gene name: HIBCH-INPP1
Fusion gene ID: hg26275tg3628
HgeneTgene
Gene symbol

HIBCH

INPP1

Gene ID

26275

3628

Gene name3-hydroxyisobutyryl-CoA hydrolaseinositol polyphosphate-1-phosphatase
SynonymsHIBYLCOAH-
Cytomap('HIBCH')('INPP1')

2q32.2

2q32.2

Type of geneprotein-codingprotein-coding
Description3-hydroxyisobutyryl-CoA hydrolase, mitochondrial3-hydroxyisobutyryl-Coenzyme A hydrolaseHIB-CoA hydrolaseHIBYL-CoA-Htesticular tissue protein Li 86inositol polyphosphate 1-phosphataseIPPIPPase
Modification date2020031320200313
UniProtAcc

Q6NVY1

P49441

Ensembl transtripts involved in fusion geneENST00000359678, ENST00000392332, 
ENST00000410045, ENST00000486981, 
Fusion gene scores* DoF score8 X 8 X 7=4485 X 6 X 3=90
# samples 96
** MAII scorelog2(9/448*10)=-2.31550182572793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HIBCH [Title/Abstract] AND INPP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHIBCH(191184441)-INPP1(191224764), # samples:1
HIBCH(191184442)-INPP1(191224765), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-8083-01AHIBCHchr2

191184442

-INPP1chr2

191224765

+
ChimerDB4LUSCTCGA-56-8083HIBCHchr2

191184441

-INPP1chr2

191224764

+


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Fusion Gene ORF analysis for HIBCH-INPP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000359678ENST00000417336HIBCHchr2

191184442

-INPP1chr2

191224765

+
5CDS-3UTRENST00000359678ENST00000417336HIBCHchr2

191184441

-INPP1chr2

191224764

+
5CDS-3UTRENST00000392332ENST00000417336HIBCHchr2

191184442

-INPP1chr2

191224765

+
5CDS-3UTRENST00000392332ENST00000417336HIBCHchr2

191184441

-INPP1chr2

191224764

+
5CDS-5UTRENST00000359678ENST00000322522HIBCHchr2

191184442

-INPP1chr2

191224765

+
5CDS-5UTRENST00000359678ENST00000322522HIBCHchr2

191184441

-INPP1chr2

191224764

+
5CDS-5UTRENST00000359678ENST00000392329HIBCHchr2

191184442

-INPP1chr2

191224765

+
5CDS-5UTRENST00000359678ENST00000392329HIBCHchr2

191184441

-INPP1chr2

191224764

+
5CDS-5UTRENST00000359678ENST00000541441HIBCHchr2

191184442

-INPP1chr2

191224765

+
5CDS-5UTRENST00000359678ENST00000541441HIBCHchr2

191184441

-INPP1chr2

191224764

+
5CDS-5UTRENST00000392332ENST00000322522HIBCHchr2

191184442

-INPP1chr2

191224765

+
5CDS-5UTRENST00000392332ENST00000322522HIBCHchr2

191184441

-INPP1chr2

191224764

+
5CDS-5UTRENST00000392332ENST00000392329HIBCHchr2

191184442

-INPP1chr2

191224765

+
5CDS-5UTRENST00000392332ENST00000392329HIBCHchr2

191184441

-INPP1chr2

191224764

+
5CDS-5UTRENST00000392332ENST00000541441HIBCHchr2

191184442

-INPP1chr2

191224765

+
5CDS-5UTRENST00000392332ENST00000541441HIBCHchr2

191184441

-INPP1chr2

191224764

+
intron-3UTRENST00000410045ENST00000417336HIBCHchr2

191184442

-INPP1chr2

191224765

+
intron-3UTRENST00000410045ENST00000417336HIBCHchr2

191184441

-INPP1chr2

191224764

+
intron-3UTRENST00000486981ENST00000417336HIBCHchr2

191184442

-INPP1chr2

191224765

+
intron-3UTRENST00000486981ENST00000417336HIBCHchr2

191184441

-INPP1chr2

191224764

+
intron-5UTRENST00000410045ENST00000322522HIBCHchr2

191184442

-INPP1chr2

191224765

+
intron-5UTRENST00000410045ENST00000322522HIBCHchr2

191184441

-INPP1chr2

191224764

+
intron-5UTRENST00000410045ENST00000392329HIBCHchr2

191184442

-INPP1chr2

191224765

+
intron-5UTRENST00000410045ENST00000392329HIBCHchr2

191184441

-INPP1chr2

191224764

+
intron-5UTRENST00000410045ENST00000541441HIBCHchr2

191184442

-INPP1chr2

191224765

+
intron-5UTRENST00000410045ENST00000541441HIBCHchr2

191184441

-INPP1chr2

191224764

+
intron-5UTRENST00000486981ENST00000322522HIBCHchr2

191184442

-INPP1chr2

191224765

+
intron-5UTRENST00000486981ENST00000322522HIBCHchr2

191184441

-INPP1chr2

191224764

+
intron-5UTRENST00000486981ENST00000392329HIBCHchr2

191184442

-INPP1chr2

191224765

+
intron-5UTRENST00000486981ENST00000392329HIBCHchr2

191184441

-INPP1chr2

191224764

+
intron-5UTRENST00000486981ENST00000541441HIBCHchr2

191184442

-INPP1chr2

191224765

+
intron-5UTRENST00000486981ENST00000541441HIBCHchr2

191184441

-INPP1chr2

191224764

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for HIBCH-INPP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HIBCHchr2191184441-INPP1chr2191224764+1.69E-091
HIBCHchr2191184441-INPP1chr2191224764+1.69E-091
HIBCHchr2191184441-INPP1chr2191224764+1.69E-091
HIBCHchr2191184441-INPP1chr2191224764+1.69E-091


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HIBCH-INPP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:191184441/:191224764)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HIBCH

Q6NVY1

INPP1

P49441

FUNCTION: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. {ECO:0000269|PubMed:8824301}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for HIBCH-INPP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HIBCH-INPP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HIBCH-INPP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HIBCH-INPP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHIBCHC0342738Beta-Hydroxyisobutyryl CoA Deacylase Deficiency9CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneHIBCHC0029408Degenerative polyarthritis1CTD_human
HgeneHIBCHC0086743Osteoarthrosis Deformans1CTD_human
TgeneC0005586Bipolar Disorder4PSYGENET
TgeneC0004352Autistic Disorder1CTD_human