Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:GNAS-CPB1 (FusionGDB2 ID:HG2778TG1360)

Fusion Gene Summary for GNAS-CPB1

check button Fusion gene summary
Fusion gene informationFusion gene name: GNAS-CPB1
Fusion gene ID: hg2778tg1360
HgeneTgene
Gene symbol

GNAS

CPB1

Gene ID

2778

1360

Gene nameGNAS complex locuscarboxypeptidase B1
SynonymsAHO|C20orf45|GNAS1|GPSA|GSA|GSP|NESP|PITA3|POH|SCG6|SgVICPB|PASP|PCPB
Cytomap('GNAS')('CPB1')

20q13.32

3q24

Type of geneprotein-codingprotein-coding
Descriptionprotein ALEXprotein GNASprotein SCG6 (secretogranin VI)G protein subunit alpha Sadenylate cyclase-stimulating G alpha proteinalternative gene product encoded by XL-exonextra large alphas proteinguanine nucleotide binding protein (G protein), alpha carboxypeptidase Bcarboxypeptidase B1 (tissue)pancreas-specific proteinpancreatic carboxypeptidase Bprocarboxypeptidase Bprotaminasetissue carboxypeptidase B
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000313949, ENST00000371075, 
ENST00000371098, ENST00000464624, 
ENST00000354359, ENST00000371081, 
ENST00000371085, ENST00000371100, 
ENST00000265620, ENST00000306090, 
ENST00000306120, ENST00000371095, 
ENST00000371099, ENST00000371102, 
Fusion gene scores* DoF score44 X 25 X 16=1760022 X 26 X 3=1716
# samples 5119
** MAII scorelog2(51/17600*10)=-5.10893437155316
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1716*10)=-3.1749782291686
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNAS [Title/Abstract] AND CPB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGNAS(57474040)-CPB1(148545789), # samples:1
Anticipated loss of major functional domain due to fusion event.GNAS-CPB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GNAS-CPB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GNAS-CPB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GNAS-CPB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCPB1

GO:0006508

proteolysis

1370825


check buttonFusion gene breakpoints across GNAS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CPB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A091-01AGNASchr20

57474040

+CPB1chr3

148545789

+


Top

Fusion Gene ORF analysis for GNAS-CPB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000313949ENST00000282957GNASchr20

57474040

+CPB1chr3

148545789

+
3UTR-3CDSENST00000313949ENST00000491148GNASchr20

57474040

+CPB1chr3

148545789

+
3UTR-3CDSENST00000371075ENST00000282957GNASchr20

57474040

+CPB1chr3

148545789

+
3UTR-3CDSENST00000371075ENST00000491148GNASchr20

57474040

+CPB1chr3

148545789

+
3UTR-3CDSENST00000371098ENST00000282957GNASchr20

57474040

+CPB1chr3

148545789

+
3UTR-3CDSENST00000371098ENST00000491148GNASchr20

57474040

+CPB1chr3

148545789

+
3UTR-3CDSENST00000464624ENST00000282957GNASchr20

57474040

+CPB1chr3

148545789

+
3UTR-3CDSENST00000464624ENST00000491148GNASchr20

57474040

+CPB1chr3

148545789

+
3UTR-intronENST00000313949ENST00000498639GNASchr20

57474040

+CPB1chr3

148545789

+
3UTR-intronENST00000371075ENST00000498639GNASchr20

57474040

+CPB1chr3

148545789

+
3UTR-intronENST00000371098ENST00000498639GNASchr20

57474040

+CPB1chr3

148545789

+
3UTR-intronENST00000464624ENST00000498639GNASchr20

57474040

+CPB1chr3

148545789

+
5CDS-intronENST00000354359ENST00000498639GNASchr20

57474040

+CPB1chr3

148545789

+
5CDS-intronENST00000371081ENST00000498639GNASchr20

57474040

+CPB1chr3

148545789

+
5CDS-intronENST00000371085ENST00000498639GNASchr20

57474040

+CPB1chr3

148545789

+
5CDS-intronENST00000371100ENST00000498639GNASchr20

57474040

+CPB1chr3

148545789

+
In-frameENST00000354359ENST00000282957GNASchr20

57474040

+CPB1chr3

148545789

+
In-frameENST00000354359ENST00000491148GNASchr20

57474040

+CPB1chr3

148545789

+
In-frameENST00000371081ENST00000282957GNASchr20

57474040

+CPB1chr3

148545789

+
In-frameENST00000371081ENST00000491148GNASchr20

57474040

+CPB1chr3

148545789

+
In-frameENST00000371085ENST00000282957GNASchr20

57474040

+CPB1chr3

148545789

+
In-frameENST00000371085ENST00000491148GNASchr20

57474040

+CPB1chr3

148545789

+
In-frameENST00000371100ENST00000282957GNASchr20

57474040

+CPB1chr3

148545789

+
In-frameENST00000371100ENST00000491148GNASchr20

57474040

+CPB1chr3

148545789

+
intron-3CDSENST00000265620ENST00000282957GNASchr20

57474040

+CPB1chr3

148545789

+
intron-3CDSENST00000265620ENST00000491148GNASchr20

57474040

+CPB1chr3

148545789

+
intron-3CDSENST00000306090ENST00000282957GNASchr20

57474040

+CPB1chr3

148545789

+
intron-3CDSENST00000306090ENST00000491148GNASchr20

57474040

+CPB1chr3

148545789

+
intron-3CDSENST00000306120ENST00000282957GNASchr20

57474040

+CPB1chr3

148545789

+
intron-3CDSENST00000306120ENST00000491148GNASchr20

57474040

+CPB1chr3

148545789

+
intron-3CDSENST00000371095ENST00000282957GNASchr20

57474040

+CPB1chr3

148545789

+
intron-3CDSENST00000371095ENST00000491148GNASchr20

57474040

+CPB1chr3

148545789

+
intron-3CDSENST00000371099ENST00000282957GNASchr20

57474040

+CPB1chr3

148545789

+
intron-3CDSENST00000371099ENST00000491148GNASchr20

57474040

+CPB1chr3

148545789

+
intron-3CDSENST00000371102ENST00000282957GNASchr20

57474040

+CPB1chr3

148545789

+
intron-3CDSENST00000371102ENST00000491148GNASchr20

57474040

+CPB1chr3

148545789

+
intron-intronENST00000265620ENST00000498639GNASchr20

57474040

+CPB1chr3

148545789

+
intron-intronENST00000306090ENST00000498639GNASchr20

57474040

+CPB1chr3

148545789

+
intron-intronENST00000306120ENST00000498639GNASchr20

57474040

+CPB1chr3

148545789

+
intron-intronENST00000371095ENST00000498639GNASchr20

57474040

+CPB1chr3

148545789

+
intron-intronENST00000371099ENST00000498639GNASchr20

57474040

+CPB1chr3

148545789

+
intron-intronENST00000371102ENST00000498639GNASchr20

57474040

+CPB1chr3

148545789

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371100GNASchr2057474040+ENST00000491148CPB1chr3148545789+4106273853139201129
ENST00000371100GNASchr2057474040+ENST00000282957CPB1chr3148545789+4102273853139201129
ENST00000371085GNASchr2057474040+ENST00000491148CPB1chr3148545789+20496814241863479
ENST00000371085GNASchr2057474040+ENST00000282957CPB1chr3148545789+20456814241863479
ENST00000354359GNASchr2057474040+ENST00000491148CPB1chr3148545789+20496814241863479
ENST00000354359GNASchr2057474040+ENST00000282957CPB1chr3148545789+20456814241863479
ENST00000371081GNASchr2057474040+ENST00000491148CPB1chr3148545789+1636268111450479
ENST00000371081GNASchr2057474040+ENST00000282957CPB1chr3148545789+1632268111450479

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371100ENST00000491148GNASchr2057474040+CPB1chr3148545789+0.0036121740.99638784
ENST00000371100ENST00000282957GNASchr2057474040+CPB1chr3148545789+0.0036507050.9963492
ENST00000371085ENST00000491148GNASchr2057474040+CPB1chr3148545789+0.0045478380.9954522
ENST00000371085ENST00000282957GNASchr2057474040+CPB1chr3148545789+0.0046088590.99539113
ENST00000354359ENST00000491148GNASchr2057474040+CPB1chr3148545789+0.0045478380.9954522
ENST00000354359ENST00000282957GNASchr2057474040+CPB1chr3148545789+0.0046088590.99539113
ENST00000371081ENST00000491148GNASchr2057474040+CPB1chr3148545789+0.0023690540.99763095
ENST00000371081ENST00000282957GNASchr2057474040+CPB1chr3148545789+0.0024210830.9975789

Top

Fusion Genomic Features for GNAS-CPB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GNASchr2057474040+CPB1chr3148545788+0.0019219030.9980781
GNASchr2057474040+CPB1chr3148545788+0.0019219030.9980781

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for GNAS-CPB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:57474040/chr3:148545789)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNASchr20:57474040chr3:148545789ENST00000371100+313641_6677281038.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57474040chr3:148545789ENST00000313949+31378_14229926.333333333333332Compositional biasGlu-rich
HgeneGNASchr20:57474040chr3:148545789ENST00000371075+31378_14229936.333333333333336Compositional biasGlu-rich
HgeneGNASchr20:57474040chr3:148545789ENST00000371098+3478_14229920.333333333333332Compositional biasGlu-rich
HgeneGNASchr20:57474040chr3:148545789ENST00000371100+313358_5227281038.0Compositional biasAla-rich
HgeneGNASchr20:57474040chr3:148545789ENST00000354359+31347_5585396.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000371085+31347_5585395.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000371100+313690_6987281038.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000354359+31342_5585396.0RegionG1 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371085+31342_5585395.0RegionG1 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371100+313685_6987281038.0RegionG1 motif
TgeneCPB1chr20:57474040chr3:148545789ENST00000282957011176_17923418.0RegionSubstrate binding
TgeneCPB1chr20:57474040chr3:148545789ENST00000282957011251_25223418.0RegionSubstrate binding
TgeneCPB1chr20:57474040chr3:148545789ENST00000282957011305_30623418.0RegionSubstrate binding
TgeneCPB1chr20:57474040chr3:148545789ENST00000491148112176_17923418.0RegionSubstrate binding
TgeneCPB1chr20:57474040chr3:148545789ENST00000491148112251_25223418.0RegionSubstrate binding
TgeneCPB1chr20:57474040chr3:148545789ENST00000491148112305_30623418.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNASchr20:57474040chr3:148545789ENST00000371100+313730_7567281038.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57474040chr3:148545789ENST00000371102+112641_66701024.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57474040chr3:148545789ENST00000371102+112730_75601024.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57474040chr3:148545789ENST00000306120+11238_4760626.0Compositional biasPro-rich
HgeneGNASchr20:57474040chr3:148545789ENST00000371102+112358_52201024.0Compositional biasAla-rich
HgeneGNASchr20:57474040chr3:148545789ENST00000265620+11239_3940380.0DomainG-alpha
HgeneGNASchr20:57474040chr3:148545789ENST00000306090+11339_3940381.0DomainG-alpha
HgeneGNASchr20:57474040chr3:148545789ENST00000354359+31339_39485396.0DomainG-alpha
HgeneGNASchr20:57474040chr3:148545789ENST00000371085+31339_39485395.0DomainG-alpha
HgeneGNASchr20:57474040chr3:148545789ENST00000371095+11239_3940381.0DomainG-alpha
HgeneGNASchr20:57474040chr3:148545789ENST00000371100+313682_10377281038.0DomainG-alpha
HgeneGNASchr20:57474040chr3:148545789ENST00000371102+112682_103701024.0DomainG-alpha
HgeneGNASchr20:57474040chr3:148545789ENST00000265620+112197_2040380.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000265620+112223_2270380.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000265620+112292_2950380.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000265620+11247_550380.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000306090+113197_2040381.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000306090+113223_2270381.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000306090+113292_2950381.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000306090+11347_550381.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000354359+313197_20485396.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000354359+313223_22785396.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000354359+313292_29585396.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000371085+313197_20485395.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000371085+313223_22785395.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000371085+313292_29585395.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000371095+112197_2040381.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000371095+112223_2270381.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000371095+112292_2950381.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000371095+11247_550381.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000371100+313840_8477281038.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000371100+313866_8707281038.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000371100+313935_9387281038.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000371102+112690_69801024.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000371102+112840_84701024.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000371102+112866_87001024.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000371102+112935_93801024.0Nucleotide bindingGTP
HgeneGNASchr20:57474040chr3:148545789ENST00000265620+112196_2040380.0RegionG2 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000265620+112219_2280380.0RegionG3 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000265620+112288_2950380.0RegionG4 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000265620+112364_3690380.0RegionG5 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000265620+11242_550380.0RegionG1 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000306090+113196_2040381.0RegionG2 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000306090+113219_2280381.0RegionG3 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000306090+113288_2950381.0RegionG4 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000306090+113364_3690381.0RegionG5 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000306090+11342_550381.0RegionG1 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000354359+313196_20485396.0RegionG2 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000354359+313219_22885396.0RegionG3 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000354359+313288_29585396.0RegionG4 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000354359+313364_36985396.0RegionG5 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371085+313196_20485395.0RegionG2 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371085+313219_22885395.0RegionG3 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371085+313288_29585395.0RegionG4 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371085+313364_36985395.0RegionG5 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371095+112196_2040381.0RegionG2 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371095+112219_2280381.0RegionG3 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371095+112288_2950381.0RegionG4 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371095+112364_3690381.0RegionG5 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371095+11242_550381.0RegionG1 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371100+3131007_10127281038.0RegionG5 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371100+313839_8477281038.0RegionG2 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371100+313862_8717281038.0RegionG3 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371100+313931_9387281038.0RegionG4 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371102+1121007_101201024.0RegionG5 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371102+112685_69801024.0RegionG1 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371102+112839_84701024.0RegionG2 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371102+112862_87101024.0RegionG3 motif
HgeneGNASchr20:57474040chr3:148545789ENST00000371102+112931_93801024.0RegionG4 motif


Top

Fusion Gene Sequence for GNAS-CPB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>33614_33614_1_GNAS-CPB1_GNAS_chr20_57474040_ENST00000354359_CPB1_chr3_148545789_ENST00000282957_length(transcript)=2045nt_BP=681nt
TCGCCGCCGCCGCCTCCTCCTCCCCCCGCCTCCCCCCGCCCGCCGCGGCGCTTTTGGCTCGGGGCGGCGGCGGGGGCCCGGCCGAGGCAA
TAAGAGCGGCGGCGGCGGCAGCGGCGGCAGCAGCTCCCGCAGCTCCTGCTCTGGTCCGCCTCGGCCCGGCGGCGGCCATCAGCCCCCTCG
GCCTCGGCTCGAGGGGCGGGGAGCTGCGCGCGCCCCTCGGTCCGACCGACACCCTCCCCTTCCCGCCCGTCCGCGCGCCCCGCGGCCCGC
GGCCCGCAGTCCGCCCCGCGCGCTCCTTGCCGAGGAGCCGAGCCCGCGCCCGGCCCGCCCGCCCGGCGCTGCCCCGGCCCTCCCGGCCCG
CGTGAGGCCGCCCGCGCCCGCCGCCGCCGCAGCCCGGCCGCGCCCCGCCGCCGCCGCCGCCGCCATGGGCTGCCTCGGGAACAGTAAGAC
CGAGGACCAGCGCAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCGAGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGGC
CACGCACCGCCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAA
TGGAGAGGGCGGCGAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGCGAGAAGGTGTTCCGTGTTAACGTTGAAGATGAAAATCA
CATTAACATAATCCGCGAGTTGGCCAGCACGACCCAGATTGACTTCTGGAAGCCAGATTCTGTCACACAAATCAAACCTCACAGTACAGT
TGACTTCCGTGTTAAAGCAGAAGATACTGTCACTGTGGAGAATGTTCTAAAGCAGAATGAACTACAATACAAGGTACTGATAAGCAACCT
GAGAAATGTGGTGGAGGCTCAGTTTGATAGCCGGGTTCGTGCAACAGGACACAGTTATGAGAAGTACAACAAGTGGGAAACGATAGAGGC
TTGGACTCAACAAGTCGCCACTGAGAATCCAGCCCTCATCTCTCGCAGTGTTATCGGAACCACATTTGAGGGACGCGCTATTTACCTCCT
GAAGGTTGGCAAAGCTGGACAAAATAAGCCTGCCATTTTCATGGACTGTGGTTTCCATGCCAGAGAGTGGATTTCTCCTGCATTCTGCCA
GTGGTTTGTAAGAGAGGCTGTTCGTACCTATGGACGTGAGATCCAAGTGACAGAGCTTCTCGACAAGTTAGACTTTTATGTCCTGCCTGT
GCTCAATATTGATGGCTACATCTACACCTGGACCAAGAGCCGATTTTGGAGAAAGACTCGCTCCACCCATACTGGATCTAGCTGCATTGG
CACAGACCCCAACAGAAATTTTGATGCTGGTTGGTGTGAAATTGGAGCCTCTCGAAACCCCTGTGATGAAACTTACTGTGGACCTGCCGC
AGAGTCTGAAAAGGAGACCAAGGCCCTGGCTGATTTCATCCGCAACAAACTCTCTTCCATCAAGGCATATCTGACAATCCACTCGTACTC
CCAAATGATGATCTACCCTTACTCATATGCTTACAAACTCGGTGAGAACAATGCTGAGTTGAATGCCCTGGCTAAAGCTACTGTGAAAGA
ACTTGCCTCACTGCACGGCACCAAGTACACATATGGCCCGGGAGCTACAACAATCTATCCTGCTGCTGGGGGCTCTGACGACTGGGCTTA
TGACCAAGGAATCAGATATTCCTTCACCTTTGAACTTCGAGATACAGGCAGATATGGCTTTCTCCTTCCAGAATCCCAGATCCGGGCTAC
CTGCGAGGAGACCTTCCTGGCAATCAAGTATGTTGCCAGCTACGTCCTGGAACACCTGTACTAGTTGAGAAAGCTGATGGCCTTGTTTCA
AAATTCTCATTTTTCATTTCTTTTCTTTCTTGAATTCTTATTTTGGTTTGCCTGGATGTTTTGCAGATCCCAATCTTTCTTTTAAGCTTC

>33614_33614_1_GNAS-CPB1_GNAS_chr20_57474040_ENST00000354359_CPB1_chr3_148545789_ENST00000282957_length(amino acids)=479AA_BP=86
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKVF
RVNVEDENHINIIRELASTTQIDFWKPDSVTQIKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNVVEAQFDSRVRATGHSYEK
YNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQWFVREAVRTYGREIQVTELLD
KLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIK
AYLTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIRYSFTFELRDTGRYGFL

--------------------------------------------------------------
>33614_33614_2_GNAS-CPB1_GNAS_chr20_57474040_ENST00000354359_CPB1_chr3_148545789_ENST00000491148_length(transcript)=2049nt_BP=681nt
TCGCCGCCGCCGCCTCCTCCTCCCCCCGCCTCCCCCCGCCCGCCGCGGCGCTTTTGGCTCGGGGCGGCGGCGGGGGCCCGGCCGAGGCAA
TAAGAGCGGCGGCGGCGGCAGCGGCGGCAGCAGCTCCCGCAGCTCCTGCTCTGGTCCGCCTCGGCCCGGCGGCGGCCATCAGCCCCCTCG
GCCTCGGCTCGAGGGGCGGGGAGCTGCGCGCGCCCCTCGGTCCGACCGACACCCTCCCCTTCCCGCCCGTCCGCGCGCCCCGCGGCCCGC
GGCCCGCAGTCCGCCCCGCGCGCTCCTTGCCGAGGAGCCGAGCCCGCGCCCGGCCCGCCCGCCCGGCGCTGCCCCGGCCCTCCCGGCCCG
CGTGAGGCCGCCCGCGCCCGCCGCCGCCGCAGCCCGGCCGCGCCCCGCCGCCGCCGCCGCCGCCATGGGCTGCCTCGGGAACAGTAAGAC
CGAGGACCAGCGCAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCGAGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGGC
CACGCACCGCCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAA
TGGAGAGGGCGGCGAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGCGAGAAGGTGTTCCGTGTTAACGTTGAAGATGAAAATCA
CATTAACATAATCCGCGAGTTGGCCAGCACGACCCAGATTGACTTCTGGAAGCCAGATTCTGTCACACAAATCAAACCTCACAGTACAGT
TGACTTCCGTGTTAAAGCAGAAGATACTGTCACTGTGGAGAATGTTCTAAAGCAGAATGAACTACAATACAAGGTACTGATAAGCAACCT
GAGAAATGTGGTGGAGGCTCAGTTTGATAGCCGGGTTCGTGCAACAGGACACAGTTATGAGAAGTACAACAAGTGGGAAACGATAGAGGC
TTGGACTCAACAAGTCGCCACTGAGAATCCAGCCCTCATCTCTCGCAGTGTTATCGGAACCACATTTGAGGGACGCGCTATTTACCTCCT
GAAGGTTGGCAAAGCTGGACAAAATAAGCCTGCCATTTTCATGGACTGTGGTTTCCATGCCAGAGAGTGGATTTCTCCTGCATTCTGCCA
GTGGTTTGTAAGAGAGGCTGTTCGTACCTATGGACGTGAGATCCAAGTGACAGAGCTTCTCGACAAGTTAGACTTTTATGTCCTGCCTGT
GCTCAATATTGATGGCTACATCTACACCTGGACCAAGAGCCGATTTTGGAGAAAGACTCGCTCCACCCATACTGGATCTAGCTGCATTGG
CACAGACCCCAACAGAAATTTTGATGCTGGTTGGTGTGAAATTGGAGCCTCTCGAAACCCCTGTGATGAAACTTACTGTGGACCTGCCGC
AGAGTCTGAAAAGGAGACCAAGGCCCTGGCTGATTTCATCCGCAACAAACTCTCTTCCATCAAGGCATATCTGACAATCCACTCGTACTC
CCAAATGATGATCTACCCTTACTCATATGCTTACAAACTCGGTGAGAACAATGCTGAGTTGAATGCCCTGGCTAAAGCTACTGTGAAAGA
ACTTGCCTCACTGCACGGCACCAAGTACACATATGGCCCGGGAGCTACAACAATCTATCCTGCTGCTGGGGGCTCTGACGACTGGGCTTA
TGACCAAGGAATCAGATATTCCTTCACCTTTGAACTTCGAGATACAGGCAGATATGGCTTTCTCCTTCCAGAATCCCAGATCCGGGCTAC
CTGCGAGGAGACCTTCCTGGCAATCAAGTATGTTGCCAGCTACGTCCTGGAACACCTGTACTAGTTGAGAAAGCTGATGGCCTTGTTTCA
AAATTCTCATTTTTCATTTCTTTTCTTTCTTGAATTCTTATTTTGGTTTGCCTGGATGTTTTGCAGATCCCAATCTTTCTTTTAAGCTTC

>33614_33614_2_GNAS-CPB1_GNAS_chr20_57474040_ENST00000354359_CPB1_chr3_148545789_ENST00000491148_length(amino acids)=479AA_BP=86
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKVF
RVNVEDENHINIIRELASTTQIDFWKPDSVTQIKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNVVEAQFDSRVRATGHSYEK
YNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQWFVREAVRTYGREIQVTELLD
KLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIK
AYLTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIRYSFTFELRDTGRYGFL

--------------------------------------------------------------
>33614_33614_3_GNAS-CPB1_GNAS_chr20_57474040_ENST00000371081_CPB1_chr3_148545789_ENST00000282957_length(transcript)=1632nt_BP=268nt
CCGCCGCCGCCATGGGCTGCCTCGGGAACAGTAAGACCGAGGACCAGCGCAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCG
AGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGGCCACGCACCGCCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTG
TGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGAGGGCGGCGAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGCG
AGAAGGTGTTCCGTGTTAACGTTGAAGATGAAAATCACATTAACATAATCCGCGAGTTGGCCAGCACGACCCAGATTGACTTCTGGAAGC
CAGATTCTGTCACACAAATCAAACCTCACAGTACAGTTGACTTCCGTGTTAAAGCAGAAGATACTGTCACTGTGGAGAATGTTCTAAAGC
AGAATGAACTACAATACAAGGTACTGATAAGCAACCTGAGAAATGTGGTGGAGGCTCAGTTTGATAGCCGGGTTCGTGCAACAGGACACA
GTTATGAGAAGTACAACAAGTGGGAAACGATAGAGGCTTGGACTCAACAAGTCGCCACTGAGAATCCAGCCCTCATCTCTCGCAGTGTTA
TCGGAACCACATTTGAGGGACGCGCTATTTACCTCCTGAAGGTTGGCAAAGCTGGACAAAATAAGCCTGCCATTTTCATGGACTGTGGTT
TCCATGCCAGAGAGTGGATTTCTCCTGCATTCTGCCAGTGGTTTGTAAGAGAGGCTGTTCGTACCTATGGACGTGAGATCCAAGTGACAG
AGCTTCTCGACAAGTTAGACTTTTATGTCCTGCCTGTGCTCAATATTGATGGCTACATCTACACCTGGACCAAGAGCCGATTTTGGAGAA
AGACTCGCTCCACCCATACTGGATCTAGCTGCATTGGCACAGACCCCAACAGAAATTTTGATGCTGGTTGGTGTGAAATTGGAGCCTCTC
GAAACCCCTGTGATGAAACTTACTGTGGACCTGCCGCAGAGTCTGAAAAGGAGACCAAGGCCCTGGCTGATTTCATCCGCAACAAACTCT
CTTCCATCAAGGCATATCTGACAATCCACTCGTACTCCCAAATGATGATCTACCCTTACTCATATGCTTACAAACTCGGTGAGAACAATG
CTGAGTTGAATGCCCTGGCTAAAGCTACTGTGAAAGAACTTGCCTCACTGCACGGCACCAAGTACACATATGGCCCGGGAGCTACAACAA
TCTATCCTGCTGCTGGGGGCTCTGACGACTGGGCTTATGACCAAGGAATCAGATATTCCTTCACCTTTGAACTTCGAGATACAGGCAGAT
ATGGCTTTCTCCTTCCAGAATCCCAGATCCGGGCTACCTGCGAGGAGACCTTCCTGGCAATCAAGTATGTTGCCAGCTACGTCCTGGAAC
ACCTGTACTAGTTGAGAAAGCTGATGGCCTTGTTTCAAAATTCTCATTTTTCATTTCTTTTCTTTCTTGAATTCTTATTTTGGTTTGCCT
GGATGTTTTGCAGATCCCAATCTTTCTTTTAAGCTTCTGGGTCTATTAAACTAGGTAGATCTTTTCGTATTGATCATAATAAAAGTGAAT

>33614_33614_3_GNAS-CPB1_GNAS_chr20_57474040_ENST00000371081_CPB1_chr3_148545789_ENST00000282957_length(amino acids)=479AA_BP=86
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKVF
RVNVEDENHINIIRELASTTQIDFWKPDSVTQIKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNVVEAQFDSRVRATGHSYEK
YNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQWFVREAVRTYGREIQVTELLD
KLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIK
AYLTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIRYSFTFELRDTGRYGFL

--------------------------------------------------------------
>33614_33614_4_GNAS-CPB1_GNAS_chr20_57474040_ENST00000371081_CPB1_chr3_148545789_ENST00000491148_length(transcript)=1636nt_BP=268nt
CCGCCGCCGCCATGGGCTGCCTCGGGAACAGTAAGACCGAGGACCAGCGCAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCG
AGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGGCCACGCACCGCCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTG
TGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGAGGGCGGCGAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGCG
AGAAGGTGTTCCGTGTTAACGTTGAAGATGAAAATCACATTAACATAATCCGCGAGTTGGCCAGCACGACCCAGATTGACTTCTGGAAGC
CAGATTCTGTCACACAAATCAAACCTCACAGTACAGTTGACTTCCGTGTTAAAGCAGAAGATACTGTCACTGTGGAGAATGTTCTAAAGC
AGAATGAACTACAATACAAGGTACTGATAAGCAACCTGAGAAATGTGGTGGAGGCTCAGTTTGATAGCCGGGTTCGTGCAACAGGACACA
GTTATGAGAAGTACAACAAGTGGGAAACGATAGAGGCTTGGACTCAACAAGTCGCCACTGAGAATCCAGCCCTCATCTCTCGCAGTGTTA
TCGGAACCACATTTGAGGGACGCGCTATTTACCTCCTGAAGGTTGGCAAAGCTGGACAAAATAAGCCTGCCATTTTCATGGACTGTGGTT
TCCATGCCAGAGAGTGGATTTCTCCTGCATTCTGCCAGTGGTTTGTAAGAGAGGCTGTTCGTACCTATGGACGTGAGATCCAAGTGACAG
AGCTTCTCGACAAGTTAGACTTTTATGTCCTGCCTGTGCTCAATATTGATGGCTACATCTACACCTGGACCAAGAGCCGATTTTGGAGAA
AGACTCGCTCCACCCATACTGGATCTAGCTGCATTGGCACAGACCCCAACAGAAATTTTGATGCTGGTTGGTGTGAAATTGGAGCCTCTC
GAAACCCCTGTGATGAAACTTACTGTGGACCTGCCGCAGAGTCTGAAAAGGAGACCAAGGCCCTGGCTGATTTCATCCGCAACAAACTCT
CTTCCATCAAGGCATATCTGACAATCCACTCGTACTCCCAAATGATGATCTACCCTTACTCATATGCTTACAAACTCGGTGAGAACAATG
CTGAGTTGAATGCCCTGGCTAAAGCTACTGTGAAAGAACTTGCCTCACTGCACGGCACCAAGTACACATATGGCCCGGGAGCTACAACAA
TCTATCCTGCTGCTGGGGGCTCTGACGACTGGGCTTATGACCAAGGAATCAGATATTCCTTCACCTTTGAACTTCGAGATACAGGCAGAT
ATGGCTTTCTCCTTCCAGAATCCCAGATCCGGGCTACCTGCGAGGAGACCTTCCTGGCAATCAAGTATGTTGCCAGCTACGTCCTGGAAC
ACCTGTACTAGTTGAGAAAGCTGATGGCCTTGTTTCAAAATTCTCATTTTTCATTTCTTTTCTTTCTTGAATTCTTATTTTGGTTTGCCT
GGATGTTTTGCAGATCCCAATCTTTCTTTTAAGCTTCTGGGTCTATTAAACTAGGTAGATCTTTTCGTATTGATCATAATAAAAGTGAAT

>33614_33614_4_GNAS-CPB1_GNAS_chr20_57474040_ENST00000371081_CPB1_chr3_148545789_ENST00000491148_length(amino acids)=479AA_BP=86
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKVF
RVNVEDENHINIIRELASTTQIDFWKPDSVTQIKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNVVEAQFDSRVRATGHSYEK
YNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQWFVREAVRTYGREIQVTELLD
KLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIK
AYLTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIRYSFTFELRDTGRYGFL

--------------------------------------------------------------
>33614_33614_5_GNAS-CPB1_GNAS_chr20_57474040_ENST00000371085_CPB1_chr3_148545789_ENST00000282957_length(transcript)=2045nt_BP=681nt
TCGCCGCCGCCGCCTCCTCCTCCCCCCGCCTCCCCCCGCCCGCCGCGGCGCTTTTGGCTCGGGGCGGCGGCGGGGGCCCGGCCGAGGCAA
TAAGAGCGGCGGCGGCGGCAGCGGCGGCAGCAGCTCCCGCAGCTCCTGCTCTGGTCCGCCTCGGCCCGGCGGCGGCCATCAGCCCCCTCG
GCCTCGGCTCGAGGGGCGGGGAGCTGCGCGCGCCCCTCGGTCCGACCGACACCCTCCCCTTCCCGCCCGTCCGCGCGCCCCGCGGCCCGC
GGCCCGCAGTCCGCCCCGCGCGCTCCTTGCCGAGGAGCCGAGCCCGCGCCCGGCCCGCCCGCCCGGCGCTGCCCCGGCCCTCCCGGCCCG
CGTGAGGCCGCCCGCGCCCGCCGCCGCCGCAGCCCGGCCGCGCCCCGCCGCCGCCGCCGCCGCCATGGGCTGCCTCGGGAACAGTAAGAC
CGAGGACCAGCGCAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCGAGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGGC
CACGCACCGCCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAA
TGGAGAGGGCGGCGAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGCGAGAAGGTGTTCCGTGTTAACGTTGAAGATGAAAATCA
CATTAACATAATCCGCGAGTTGGCCAGCACGACCCAGATTGACTTCTGGAAGCCAGATTCTGTCACACAAATCAAACCTCACAGTACAGT
TGACTTCCGTGTTAAAGCAGAAGATACTGTCACTGTGGAGAATGTTCTAAAGCAGAATGAACTACAATACAAGGTACTGATAAGCAACCT
GAGAAATGTGGTGGAGGCTCAGTTTGATAGCCGGGTTCGTGCAACAGGACACAGTTATGAGAAGTACAACAAGTGGGAAACGATAGAGGC
TTGGACTCAACAAGTCGCCACTGAGAATCCAGCCCTCATCTCTCGCAGTGTTATCGGAACCACATTTGAGGGACGCGCTATTTACCTCCT
GAAGGTTGGCAAAGCTGGACAAAATAAGCCTGCCATTTTCATGGACTGTGGTTTCCATGCCAGAGAGTGGATTTCTCCTGCATTCTGCCA
GTGGTTTGTAAGAGAGGCTGTTCGTACCTATGGACGTGAGATCCAAGTGACAGAGCTTCTCGACAAGTTAGACTTTTATGTCCTGCCTGT
GCTCAATATTGATGGCTACATCTACACCTGGACCAAGAGCCGATTTTGGAGAAAGACTCGCTCCACCCATACTGGATCTAGCTGCATTGG
CACAGACCCCAACAGAAATTTTGATGCTGGTTGGTGTGAAATTGGAGCCTCTCGAAACCCCTGTGATGAAACTTACTGTGGACCTGCCGC
AGAGTCTGAAAAGGAGACCAAGGCCCTGGCTGATTTCATCCGCAACAAACTCTCTTCCATCAAGGCATATCTGACAATCCACTCGTACTC
CCAAATGATGATCTACCCTTACTCATATGCTTACAAACTCGGTGAGAACAATGCTGAGTTGAATGCCCTGGCTAAAGCTACTGTGAAAGA
ACTTGCCTCACTGCACGGCACCAAGTACACATATGGCCCGGGAGCTACAACAATCTATCCTGCTGCTGGGGGCTCTGACGACTGGGCTTA
TGACCAAGGAATCAGATATTCCTTCACCTTTGAACTTCGAGATACAGGCAGATATGGCTTTCTCCTTCCAGAATCCCAGATCCGGGCTAC
CTGCGAGGAGACCTTCCTGGCAATCAAGTATGTTGCCAGCTACGTCCTGGAACACCTGTACTAGTTGAGAAAGCTGATGGCCTTGTTTCA
AAATTCTCATTTTTCATTTCTTTTCTTTCTTGAATTCTTATTTTGGTTTGCCTGGATGTTTTGCAGATCCCAATCTTTCTTTTAAGCTTC

>33614_33614_5_GNAS-CPB1_GNAS_chr20_57474040_ENST00000371085_CPB1_chr3_148545789_ENST00000282957_length(amino acids)=479AA_BP=86
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKVF
RVNVEDENHINIIRELASTTQIDFWKPDSVTQIKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNVVEAQFDSRVRATGHSYEK
YNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQWFVREAVRTYGREIQVTELLD
KLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIK
AYLTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIRYSFTFELRDTGRYGFL

--------------------------------------------------------------
>33614_33614_6_GNAS-CPB1_GNAS_chr20_57474040_ENST00000371085_CPB1_chr3_148545789_ENST00000491148_length(transcript)=2049nt_BP=681nt
TCGCCGCCGCCGCCTCCTCCTCCCCCCGCCTCCCCCCGCCCGCCGCGGCGCTTTTGGCTCGGGGCGGCGGCGGGGGCCCGGCCGAGGCAA
TAAGAGCGGCGGCGGCGGCAGCGGCGGCAGCAGCTCCCGCAGCTCCTGCTCTGGTCCGCCTCGGCCCGGCGGCGGCCATCAGCCCCCTCG
GCCTCGGCTCGAGGGGCGGGGAGCTGCGCGCGCCCCTCGGTCCGACCGACACCCTCCCCTTCCCGCCCGTCCGCGCGCCCCGCGGCCCGC
GGCCCGCAGTCCGCCCCGCGCGCTCCTTGCCGAGGAGCCGAGCCCGCGCCCGGCCCGCCCGCCCGGCGCTGCCCCGGCCCTCCCGGCCCG
CGTGAGGCCGCCCGCGCCCGCCGCCGCCGCAGCCCGGCCGCGCCCCGCCGCCGCCGCCGCCGCCATGGGCTGCCTCGGGAACAGTAAGAC
CGAGGACCAGCGCAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCGAGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGGC
CACGCACCGCCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAA
TGGAGAGGGCGGCGAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGCGAGAAGGTGTTCCGTGTTAACGTTGAAGATGAAAATCA
CATTAACATAATCCGCGAGTTGGCCAGCACGACCCAGATTGACTTCTGGAAGCCAGATTCTGTCACACAAATCAAACCTCACAGTACAGT
TGACTTCCGTGTTAAAGCAGAAGATACTGTCACTGTGGAGAATGTTCTAAAGCAGAATGAACTACAATACAAGGTACTGATAAGCAACCT
GAGAAATGTGGTGGAGGCTCAGTTTGATAGCCGGGTTCGTGCAACAGGACACAGTTATGAGAAGTACAACAAGTGGGAAACGATAGAGGC
TTGGACTCAACAAGTCGCCACTGAGAATCCAGCCCTCATCTCTCGCAGTGTTATCGGAACCACATTTGAGGGACGCGCTATTTACCTCCT
GAAGGTTGGCAAAGCTGGACAAAATAAGCCTGCCATTTTCATGGACTGTGGTTTCCATGCCAGAGAGTGGATTTCTCCTGCATTCTGCCA
GTGGTTTGTAAGAGAGGCTGTTCGTACCTATGGACGTGAGATCCAAGTGACAGAGCTTCTCGACAAGTTAGACTTTTATGTCCTGCCTGT
GCTCAATATTGATGGCTACATCTACACCTGGACCAAGAGCCGATTTTGGAGAAAGACTCGCTCCACCCATACTGGATCTAGCTGCATTGG
CACAGACCCCAACAGAAATTTTGATGCTGGTTGGTGTGAAATTGGAGCCTCTCGAAACCCCTGTGATGAAACTTACTGTGGACCTGCCGC
AGAGTCTGAAAAGGAGACCAAGGCCCTGGCTGATTTCATCCGCAACAAACTCTCTTCCATCAAGGCATATCTGACAATCCACTCGTACTC
CCAAATGATGATCTACCCTTACTCATATGCTTACAAACTCGGTGAGAACAATGCTGAGTTGAATGCCCTGGCTAAAGCTACTGTGAAAGA
ACTTGCCTCACTGCACGGCACCAAGTACACATATGGCCCGGGAGCTACAACAATCTATCCTGCTGCTGGGGGCTCTGACGACTGGGCTTA
TGACCAAGGAATCAGATATTCCTTCACCTTTGAACTTCGAGATACAGGCAGATATGGCTTTCTCCTTCCAGAATCCCAGATCCGGGCTAC
CTGCGAGGAGACCTTCCTGGCAATCAAGTATGTTGCCAGCTACGTCCTGGAACACCTGTACTAGTTGAGAAAGCTGATGGCCTTGTTTCA
AAATTCTCATTTTTCATTTCTTTTCTTTCTTGAATTCTTATTTTGGTTTGCCTGGATGTTTTGCAGATCCCAATCTTTCTTTTAAGCTTC

>33614_33614_6_GNAS-CPB1_GNAS_chr20_57474040_ENST00000371085_CPB1_chr3_148545789_ENST00000491148_length(amino acids)=479AA_BP=86
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKVF
RVNVEDENHINIIRELASTTQIDFWKPDSVTQIKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNVVEAQFDSRVRATGHSYEK
YNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQWFVREAVRTYGREIQVTELLD
KLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIK
AYLTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIRYSFTFELRDTGRYGFL

--------------------------------------------------------------
>33614_33614_7_GNAS-CPB1_GNAS_chr20_57474040_ENST00000371100_CPB1_chr3_148545789_ENST00000282957_length(transcript)=4102nt_BP=2738nt
AAAGACTCCAAATCAGTCAGGGAGAGGAGTGGAAGGAGCCAAAACGTCCCTGCGAGGCCTGCGCTCACCAGCCCCCTTACCCAAAGTCCC
GGGCCCCTGGCGCCAGGAGCAGGCTCCTGGAGCCGGAGCCAGCTCGGCACTGGAACCGGCGTCCTCTGGTGGCAGAGAGAGAGCGCTACT
GGCGATTTTCGGACCGAATCGGCACGCTCGTCAGATCCAAGCAGGCGGGACTGGCCTGGAGCAAAAAGAAAGAGAGAGGAGGGCGTAAGG
ATAGACCAAGGAAGAGGGGCTGGGGGGCAGCCTGGGGGCATGAAAAGTGGCCAGGAAGGAGCCAAGACTCCACCAGCAACAATTGAGTTG
CTTCAGCCTCAGTCTAGGGTTCCTTCCAGGCCTTGAACCCCCCAACCTCACAAGGGTTGGAAAGTGAGGCCGGTGAACTTTCCAGCTGGT
ACTTTGATTTTAAAATAATAATAATAATTTTTTCACCCTAGTTCGGTTGGGTGCTCCATCTTACGGAGCCCCAAACTTATTTTGAGAGGC
CGCCACCGTGTTATGGGCGTGCGCAACTGCCTCTACGGCAATAATATGTCAGGACAACGCGATATCCCCCCTGAAATCGGGGAACAGCCC
GAGCAACCACCTTTGGAGGCCCCAGGGGCAGCTGCCCCCGGTGCTGGGCCTAGCCCAGCCGAAGAGATGGAGACCGAACCGCCTCACAAC
GAGCCCATCCCCGTCGAGAATGATGGCGAGGCCTGTGGACCCCCAGAGGTCTCCAGACCCAACTTTCAGGTCCTCAACCCGGCATTCAGG
GAAGCTGGAGCCCATGGAAGCTACAGCCCACCTCCTGAGGAAGCAATGCCCTTCGAGGCTGAACAGCCCAGCTTGGGAGGCTTCTGGCCT
ACACTGGAGCAGCCTGGATTCCCCAGTGGGGTCCATGCAGGCCTTGAGGCCTTCGGCCCAGCACTCATGGAGCCCGGAGCCTTCAGTGGT
GCCAGACCAGGCCTGGGAGGATACAGCCCTCCACCAGAAGAAGCTATGCCCTTTGAGTTTGACCAGCCTGCCCAGAGAGGCTGCAGTCAA
CTTCTCTTACAGGTCCCAGACCTTGCTCCAGGAGGCCCAGGTGCTGCAGGGGTCCCCGGAGCTCCTCCCGAGGAGCCCCAAGCCCTCAGG
CCTGCAAAGGCTGGCTCCAGAGGAGGCTACAGCCCTCCCCCTGAGGAGACTATGCCATTTGAGCTTGATGGAGAAGGATTTGGGGACGAC
AGCCCACCCCCGGGGCTTTCCCGAGTTATCGCACAAGTCGACGGCAGCAGCCAGTTCGCGGCAGTCGCGGCCTCGAGTGCGGTCCGCCTC
ACTCCCGCCGCGAACGCGCCTCCCCTCTGGGTCCCAGGCGCCATCGGCAGCCCATCCCAAGAGGCTGTCAGACCTCCTTCTAACTTCACG
GGCAGCAGCCCCTGGATGGAGATCTCCGGACCCCCGTTCGAGATTGGCAGCGCCCCCGCTGGGGTCGACGACACTCCCGTCAACATGGAC
AGCCCCCCAATCGCGCTTGACGGCCCGCCCATCAAGGTCTCCGGAGCCCCAGATAAGAGAGAGCGAGCAGAGAGACCCCCAGTTGAGGAG
GAAGCAGCAGAGATGGAAGGAGCCGCTGATGCCGCGGAGGGAGGAAAAGTACCCTCTCCGGGGTACGGATCCCCTGCCGCCGGGGCAGCC
TCAGCGGATACCGCTGCCAGGGCAGCCCCTGCAGCCCCAGCCGATCCTGACTCCGGGGCAACCCCAGAAGATCCCGACTCCGGGACAGCA
CCAGCCGATCCTGACTCCGGGGCATTCGCAGCCGATCCCGACTCCGGGGCAGCCCCTGCCGCCCCAGCCGATCCCGACTCCGGGGCGGCC
CCTGACGCCCCAGCCGATCCCGACTCCGGGGCGGCCCCTGACGCCCCAGCCGATCCAGATGCCGGGGCGGCCCCTGAGGCTCCCGCCGCC
CCTGCGGCTGCTGAGACCCGGGCAGCCCATGTCGCCCCAGCTGCGCCAGACGCAGGGGCTCCCACTGCCCCAGCCGCTTCTGCCACCCGG
GCAGCCCAAGTCCGCCGGGCGGCCTCTGCAGCCCCTGCCTCCGGGGCCAGACGCAAGATCCATCTCAGACCCCCCAGCCCCGAGATCCAG
GCTGCCGATCCGCCTACTCCGCGGCCTACTCGCGCGTCTGCCTGGCGGGGCAAGTCCGAGAGCAGCCGCGGCCGCCGCGTGTACTACGAT
GAAGGGGTGGCCAGCAGCGACGATGACTCCAGCGGAGACGAGTCCGACGATGGGACCTCCGGATGCCTCCGCTGGTTTCAGCATCGGCGA
AATCGCCGCCGCCGAAAGCCCCAGCGCAACTTACTCCGCAACTTTCTCGTGCAAGCCTTCGGGGGCTGCTTCGGTCGATCTGAGAGTCCC
CAGCCCAAAGCCTCGCGCTCTCTCAAGGTCAAGAAGGTACCCCTGGCGGAGAAGCGCAGACAGATGCGCAAAGAAGCCCTGGAGAAGCGG
GCCCAGAAGCGCGCAGAGAAGAAACGCAGTAAGCTCATCGACAAACAACTCCAGGACGAAAAGATGGGCTACATGTGTACGCACCGCCTG
CTGCTTCTAGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGAGGGCGGC
GAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGCGAGAAGGTGTTCCGTGTTAACGTTGAAGATGAAAATCACATTAACATAATC
CGCGAGTTGGCCAGCACGACCCAGATTGACTTCTGGAAGCCAGATTCTGTCACACAAATCAAACCTCACAGTACAGTTGACTTCCGTGTT
AAAGCAGAAGATACTGTCACTGTGGAGAATGTTCTAAAGCAGAATGAACTACAATACAAGGTACTGATAAGCAACCTGAGAAATGTGGTG
GAGGCTCAGTTTGATAGCCGGGTTCGTGCAACAGGACACAGTTATGAGAAGTACAACAAGTGGGAAACGATAGAGGCTTGGACTCAACAA
GTCGCCACTGAGAATCCAGCCCTCATCTCTCGCAGTGTTATCGGAACCACATTTGAGGGACGCGCTATTTACCTCCTGAAGGTTGGCAAA
GCTGGACAAAATAAGCCTGCCATTTTCATGGACTGTGGTTTCCATGCCAGAGAGTGGATTTCTCCTGCATTCTGCCAGTGGTTTGTAAGA
GAGGCTGTTCGTACCTATGGACGTGAGATCCAAGTGACAGAGCTTCTCGACAAGTTAGACTTTTATGTCCTGCCTGTGCTCAATATTGAT
GGCTACATCTACACCTGGACCAAGAGCCGATTTTGGAGAAAGACTCGCTCCACCCATACTGGATCTAGCTGCATTGGCACAGACCCCAAC
AGAAATTTTGATGCTGGTTGGTGTGAAATTGGAGCCTCTCGAAACCCCTGTGATGAAACTTACTGTGGACCTGCCGCAGAGTCTGAAAAG
GAGACCAAGGCCCTGGCTGATTTCATCCGCAACAAACTCTCTTCCATCAAGGCATATCTGACAATCCACTCGTACTCCCAAATGATGATC
TACCCTTACTCATATGCTTACAAACTCGGTGAGAACAATGCTGAGTTGAATGCCCTGGCTAAAGCTACTGTGAAAGAACTTGCCTCACTG
CACGGCACCAAGTACACATATGGCCCGGGAGCTACAACAATCTATCCTGCTGCTGGGGGCTCTGACGACTGGGCTTATGACCAAGGAATC
AGATATTCCTTCACCTTTGAACTTCGAGATACAGGCAGATATGGCTTTCTCCTTCCAGAATCCCAGATCCGGGCTACCTGCGAGGAGACC
TTCCTGGCAATCAAGTATGTTGCCAGCTACGTCCTGGAACACCTGTACTAGTTGAGAAAGCTGATGGCCTTGTTTCAAAATTCTCATTTT
TCATTTCTTTTCTTTCTTGAATTCTTATTTTGGTTTGCCTGGATGTTTTGCAGATCCCAATCTTTCTTTTAAGCTTCTGGGTCTATTAAA

>33614_33614_7_GNAS-CPB1_GNAS_chr20_57474040_ENST00000371100_CPB1_chr3_148545789_ENST00000282957_length(amino acids)=1129AA_BP=736
MRGRHRVMGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNP
AFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRG
CSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSA
VRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPP
VEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDS
GAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSP
EIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRS
ESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNG
EGGEEDPQAARSNSDGEKVFRVNVEDENHINIIRELASTTQIDFWKPDSVTQIKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLR
NVVEAQFDSRVRATGHSYEKYNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQW
FVREAVRTYGREIQVTELLDKLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAE
SEKETKALADFIRNKLSSIKAYLTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYD

--------------------------------------------------------------
>33614_33614_8_GNAS-CPB1_GNAS_chr20_57474040_ENST00000371100_CPB1_chr3_148545789_ENST00000491148_length(transcript)=4106nt_BP=2738nt
AAAGACTCCAAATCAGTCAGGGAGAGGAGTGGAAGGAGCCAAAACGTCCCTGCGAGGCCTGCGCTCACCAGCCCCCTTACCCAAAGTCCC
GGGCCCCTGGCGCCAGGAGCAGGCTCCTGGAGCCGGAGCCAGCTCGGCACTGGAACCGGCGTCCTCTGGTGGCAGAGAGAGAGCGCTACT
GGCGATTTTCGGACCGAATCGGCACGCTCGTCAGATCCAAGCAGGCGGGACTGGCCTGGAGCAAAAAGAAAGAGAGAGGAGGGCGTAAGG
ATAGACCAAGGAAGAGGGGCTGGGGGGCAGCCTGGGGGCATGAAAAGTGGCCAGGAAGGAGCCAAGACTCCACCAGCAACAATTGAGTTG
CTTCAGCCTCAGTCTAGGGTTCCTTCCAGGCCTTGAACCCCCCAACCTCACAAGGGTTGGAAAGTGAGGCCGGTGAACTTTCCAGCTGGT
ACTTTGATTTTAAAATAATAATAATAATTTTTTCACCCTAGTTCGGTTGGGTGCTCCATCTTACGGAGCCCCAAACTTATTTTGAGAGGC
CGCCACCGTGTTATGGGCGTGCGCAACTGCCTCTACGGCAATAATATGTCAGGACAACGCGATATCCCCCCTGAAATCGGGGAACAGCCC
GAGCAACCACCTTTGGAGGCCCCAGGGGCAGCTGCCCCCGGTGCTGGGCCTAGCCCAGCCGAAGAGATGGAGACCGAACCGCCTCACAAC
GAGCCCATCCCCGTCGAGAATGATGGCGAGGCCTGTGGACCCCCAGAGGTCTCCAGACCCAACTTTCAGGTCCTCAACCCGGCATTCAGG
GAAGCTGGAGCCCATGGAAGCTACAGCCCACCTCCTGAGGAAGCAATGCCCTTCGAGGCTGAACAGCCCAGCTTGGGAGGCTTCTGGCCT
ACACTGGAGCAGCCTGGATTCCCCAGTGGGGTCCATGCAGGCCTTGAGGCCTTCGGCCCAGCACTCATGGAGCCCGGAGCCTTCAGTGGT
GCCAGACCAGGCCTGGGAGGATACAGCCCTCCACCAGAAGAAGCTATGCCCTTTGAGTTTGACCAGCCTGCCCAGAGAGGCTGCAGTCAA
CTTCTCTTACAGGTCCCAGACCTTGCTCCAGGAGGCCCAGGTGCTGCAGGGGTCCCCGGAGCTCCTCCCGAGGAGCCCCAAGCCCTCAGG
CCTGCAAAGGCTGGCTCCAGAGGAGGCTACAGCCCTCCCCCTGAGGAGACTATGCCATTTGAGCTTGATGGAGAAGGATTTGGGGACGAC
AGCCCACCCCCGGGGCTTTCCCGAGTTATCGCACAAGTCGACGGCAGCAGCCAGTTCGCGGCAGTCGCGGCCTCGAGTGCGGTCCGCCTC
ACTCCCGCCGCGAACGCGCCTCCCCTCTGGGTCCCAGGCGCCATCGGCAGCCCATCCCAAGAGGCTGTCAGACCTCCTTCTAACTTCACG
GGCAGCAGCCCCTGGATGGAGATCTCCGGACCCCCGTTCGAGATTGGCAGCGCCCCCGCTGGGGTCGACGACACTCCCGTCAACATGGAC
AGCCCCCCAATCGCGCTTGACGGCCCGCCCATCAAGGTCTCCGGAGCCCCAGATAAGAGAGAGCGAGCAGAGAGACCCCCAGTTGAGGAG
GAAGCAGCAGAGATGGAAGGAGCCGCTGATGCCGCGGAGGGAGGAAAAGTACCCTCTCCGGGGTACGGATCCCCTGCCGCCGGGGCAGCC
TCAGCGGATACCGCTGCCAGGGCAGCCCCTGCAGCCCCAGCCGATCCTGACTCCGGGGCAACCCCAGAAGATCCCGACTCCGGGACAGCA
CCAGCCGATCCTGACTCCGGGGCATTCGCAGCCGATCCCGACTCCGGGGCAGCCCCTGCCGCCCCAGCCGATCCCGACTCCGGGGCGGCC
CCTGACGCCCCAGCCGATCCCGACTCCGGGGCGGCCCCTGACGCCCCAGCCGATCCAGATGCCGGGGCGGCCCCTGAGGCTCCCGCCGCC
CCTGCGGCTGCTGAGACCCGGGCAGCCCATGTCGCCCCAGCTGCGCCAGACGCAGGGGCTCCCACTGCCCCAGCCGCTTCTGCCACCCGG
GCAGCCCAAGTCCGCCGGGCGGCCTCTGCAGCCCCTGCCTCCGGGGCCAGACGCAAGATCCATCTCAGACCCCCCAGCCCCGAGATCCAG
GCTGCCGATCCGCCTACTCCGCGGCCTACTCGCGCGTCTGCCTGGCGGGGCAAGTCCGAGAGCAGCCGCGGCCGCCGCGTGTACTACGAT
GAAGGGGTGGCCAGCAGCGACGATGACTCCAGCGGAGACGAGTCCGACGATGGGACCTCCGGATGCCTCCGCTGGTTTCAGCATCGGCGA
AATCGCCGCCGCCGAAAGCCCCAGCGCAACTTACTCCGCAACTTTCTCGTGCAAGCCTTCGGGGGCTGCTTCGGTCGATCTGAGAGTCCC
CAGCCCAAAGCCTCGCGCTCTCTCAAGGTCAAGAAGGTACCCCTGGCGGAGAAGCGCAGACAGATGCGCAAAGAAGCCCTGGAGAAGCGG
GCCCAGAAGCGCGCAGAGAAGAAACGCAGTAAGCTCATCGACAAACAACTCCAGGACGAAAAGATGGGCTACATGTGTACGCACCGCCTG
CTGCTTCTAGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGAGGGCGGC
GAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGCGAGAAGGTGTTCCGTGTTAACGTTGAAGATGAAAATCACATTAACATAATC
CGCGAGTTGGCCAGCACGACCCAGATTGACTTCTGGAAGCCAGATTCTGTCACACAAATCAAACCTCACAGTACAGTTGACTTCCGTGTT
AAAGCAGAAGATACTGTCACTGTGGAGAATGTTCTAAAGCAGAATGAACTACAATACAAGGTACTGATAAGCAACCTGAGAAATGTGGTG
GAGGCTCAGTTTGATAGCCGGGTTCGTGCAACAGGACACAGTTATGAGAAGTACAACAAGTGGGAAACGATAGAGGCTTGGACTCAACAA
GTCGCCACTGAGAATCCAGCCCTCATCTCTCGCAGTGTTATCGGAACCACATTTGAGGGACGCGCTATTTACCTCCTGAAGGTTGGCAAA
GCTGGACAAAATAAGCCTGCCATTTTCATGGACTGTGGTTTCCATGCCAGAGAGTGGATTTCTCCTGCATTCTGCCAGTGGTTTGTAAGA
GAGGCTGTTCGTACCTATGGACGTGAGATCCAAGTGACAGAGCTTCTCGACAAGTTAGACTTTTATGTCCTGCCTGTGCTCAATATTGAT
GGCTACATCTACACCTGGACCAAGAGCCGATTTTGGAGAAAGACTCGCTCCACCCATACTGGATCTAGCTGCATTGGCACAGACCCCAAC
AGAAATTTTGATGCTGGTTGGTGTGAAATTGGAGCCTCTCGAAACCCCTGTGATGAAACTTACTGTGGACCTGCCGCAGAGTCTGAAAAG
GAGACCAAGGCCCTGGCTGATTTCATCCGCAACAAACTCTCTTCCATCAAGGCATATCTGACAATCCACTCGTACTCCCAAATGATGATC
TACCCTTACTCATATGCTTACAAACTCGGTGAGAACAATGCTGAGTTGAATGCCCTGGCTAAAGCTACTGTGAAAGAACTTGCCTCACTG
CACGGCACCAAGTACACATATGGCCCGGGAGCTACAACAATCTATCCTGCTGCTGGGGGCTCTGACGACTGGGCTTATGACCAAGGAATC
AGATATTCCTTCACCTTTGAACTTCGAGATACAGGCAGATATGGCTTTCTCCTTCCAGAATCCCAGATCCGGGCTACCTGCGAGGAGACC
TTCCTGGCAATCAAGTATGTTGCCAGCTACGTCCTGGAACACCTGTACTAGTTGAGAAAGCTGATGGCCTTGTTTCAAAATTCTCATTTT
TCATTTCTTTTCTTTCTTGAATTCTTATTTTGGTTTGCCTGGATGTTTTGCAGATCCCAATCTTTCTTTTAAGCTTCTGGGTCTATTAAA

>33614_33614_8_GNAS-CPB1_GNAS_chr20_57474040_ENST00000371100_CPB1_chr3_148545789_ENST00000491148_length(amino acids)=1129AA_BP=736
MRGRHRVMGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNP
AFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRG
CSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSA
VRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPP
VEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDS
GAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSP
EIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRS
ESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNG
EGGEEDPQAARSNSDGEKVFRVNVEDENHINIIRELASTTQIDFWKPDSVTQIKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLR
NVVEAQFDSRVRATGHSYEKYNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQW
FVREAVRTYGREIQVTELLDKLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAE
SEKETKALADFIRNKLSSIKAYLTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GNAS-CPB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for GNAS-CPB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for GNAS-CPB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGNASC3494506Pseudohypoparathyroidism, Type Ia17CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGNASC0242292McCune-Albright Syndrome7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGNASC0016065Polyostotic fibrous dysplasia5CTD_human;ORPHANET
HgeneGNASC1864100PSEUDOHYPOPARATHYROIDISM, TYPE IB5CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneGNASC2931404Albright's hereditary osteodystrophy4CTD_human;GENOMICS_ENGLAND
HgeneGNASC0033806Pseudohypoparathyroidism3CTD_human
HgeneGNASC0334041Osteoma cutis3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGNASC0014130Endocrine System Diseases2CTD_human
HgeneGNASC0016064Fibrous Dysplasia, Monostotic2ORPHANET
HgeneGNASC0034013Precocious Puberty2CTD_human
HgeneGNASC0221263Cafe-au-Lait Spots2CTD_human
HgeneGNASC0271527Cryptogenic sexual precocity2CTD_human
HgeneGNASC0342543Central Precocious Puberty2CTD_human
HgeneGNASC1504412Testotoxicosis2CTD_human
HgeneGNASC1857451Acth-Independent Macronodular Adrenal Hyperplasia2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGNASC2932716Pseudohypoparathyroidism Type 1C2GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGNASC0001206Acromegaly1CTD_human
HgeneGNASC0001624Adrenal Gland Neoplasms1CTD_human
HgeneGNASC0003129Anoxemia1CTD_human
HgeneGNASC0003130Anoxia1CTD_human
HgeneGNASC0008370Cholestasis1GENOMICS_ENGLAND
HgeneGNASC0009438Common Bile Duct Calculi1CTD_human
HgeneGNASC0011573Endogenous depression1PSYGENET
HgeneGNASC0019087Hemorrhagic Disorders1CTD_human
HgeneGNASC0020538Hypertensive disease1CTD_human
HgeneGNASC0020796Profound Mental Retardation1CTD_human
HgeneGNASC0021655Insulin Resistance1CTD_human
HgeneGNASC0023897Liver Diseases, Parasitic1CTD_human
HgeneGNASC0025363Mental Retardation, Psychosocial1CTD_human
HgeneGNASC0027819Neuroblastoma1CTD_human
HgeneGNASC0028754Obesity1CTD_human
HgeneGNASC0029396Heterotopic Ossification1CTD_human
HgeneGNASC0032460Polycystic Ovary Syndrome1CTD_human
HgeneGNASC0033835Pseudopseudohypoparathyroidism1CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneGNASC0035204Respiration Disorders1CTD_human
HgeneGNASC0036341Schizophrenia1PSYGENET
HgeneGNASC0038587Substance Withdrawal Syndrome1CTD_human
HgeneGNASC0039231Tachycardia1CTD_human
HgeneGNASC0080203Tachyarrhythmia1CTD_human
HgeneGNASC0086189Drug Withdrawal Symptoms1CTD_human
HgeneGNASC0087169Withdrawal Symptoms1CTD_human
HgeneGNASC0206698Cholangiocarcinoma1CTD_human
HgeneGNASC0221357Brachydactyly1CTD_human
HgeneGNASC0242184Hypoxia1CTD_human
HgeneGNASC0242216Biliary calculi1CTD_human
HgeneGNASC0345905Intrahepatic Cholangiocarcinoma1CTD_human
HgeneGNASC0346302Growth Hormone-Secreting Pituitary Adenoma1CTD_human
HgeneGNASC0700292Hypoxemia1CTD_human
HgeneGNASC0750887Adrenal Cancer1CTD_human
HgeneGNASC0917816Mental deficiency1CTD_human
HgeneGNASC0920563Insulin Sensitivity1CTD_human
HgeneGNASC1136382Sclerocystic Ovaries1CTD_human
HgeneGNASC2932715Pseudohypoparathyroidism Type 1B1CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneGNASC3489630Somatotrophinoma, Familial1CTD_human
HgeneGNASC3697137Fibrous dysplasia of bone with intramuscular myxoma1ORPHANET
HgeneGNASC3714756Intellectual Disability1CTD_human
HgeneGNASC3805278Extrahepatic Cholangiocarcinoma1CTD_human