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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:GRN-IGFBP5 (FusionGDB2 ID:HG2896TG3488) |
Fusion Gene Summary for GRN-IGFBP5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GRN-IGFBP5 | Fusion gene ID: hg2896tg3488 | Hgene | Tgene | Gene symbol | GRN | IGFBP5 | Gene ID | 2896 | 3488 |
| Gene name | granulin precursor | insulin like growth factor binding protein 5 | |
| Synonyms | CLN11|GEP|GP88|PCDGF|PEPI|PGRN | IBP5 | |
| Cytomap | ('GRN')('IGFBP5') 17q21.31 | 2q35 | |
| Type of gene | protein-coding | protein-coding | |
| Description | progranulinPC cell-derived growth factoracrograninepithelinglycoprotein 88glycoprotein of 88 Kdagranulin-epithelingranulinsproepithelin | insulin-like growth factor-binding protein 5IBP-5IGF-binding protein 5IGFBP-5 | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | P28799 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000053867, ENST00000589265, ENST00000589923, | ||
| Fusion gene scores | * DoF score | 15 X 12 X 6=1080 | 15 X 20 X 2=600 |
| # samples | 18 | 20 | |
| ** MAII score | log2(18/1080*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/600*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GRN [Title/Abstract] AND IGFBP5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | GRN(42426672)-IGFBP5(217552577), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GRN | GO:0043524 | negative regulation of neuron apoptotic process | 18378771 |
| Hgene | GRN | GO:0050679 | positive regulation of epithelial cell proliferation | 12526812 |
| Hgene | GRN | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response | 12526812 |
| Hgene | GRN | GO:1902564 | negative regulation of neutrophil activation | 12526812 |
| Hgene | GRN | GO:1905673 | positive regulation of lysosome organization | 28073925 |
| Tgene | IGFBP5 | GO:0014912 | negative regulation of smooth muscle cell migration | 10766744 |
| Tgene | IGFBP5 | GO:0017148 | negative regulation of translation | 15700281 |
| Tgene | IGFBP5 | GO:0030336 | negative regulation of cell migration | 15700281 |
| Tgene | IGFBP5 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway | 10766744 |
| Tgene | IGFBP5 | GO:0048662 | negative regulation of smooth muscle cell proliferation | 10766744 |
| Tgene | IGFBP5 | GO:0071320 | cellular response to cAMP | 7559606 |
| Tgene | IGFBP5 | GO:0071407 | cellular response to organic cyclic compound | 7559606 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BM146907 | GRN | chr17 | 42426672 | + | IGFBP5 | chr2 | 217552577 | - |
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Fusion Gene ORF analysis for GRN-IGFBP5 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000053867 | ENST00000233813 | GRN | chr17 | 42426672 | + | IGFBP5 | chr2 | 217552577 | - |
| 5CDS-intron | ENST00000589265 | ENST00000233813 | GRN | chr17 | 42426672 | + | IGFBP5 | chr2 | 217552577 | - |
| intron-intron | ENST00000589923 | ENST00000233813 | GRN | chr17 | 42426672 | + | IGFBP5 | chr2 | 217552577 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for GRN-IGFBP5 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for GRN-IGFBP5 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:42426672/:217552577) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GRN | . |
| FUNCTION: Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:28541286, PubMed:28073925, PubMed:18378771, PubMed:28453791, PubMed:12526812). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (PubMed:28453791, PubMed:28541286). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:18378771). {ECO:0000250|UniProtKB:P28798, ECO:0000269|PubMed:12526812, ECO:0000269|PubMed:18378771, ECO:0000269|PubMed:28073925, ECO:0000269|PubMed:28453791, ECO:0000269|PubMed:28541286}.; FUNCTION: [Granulin-4]: Promotes proliferation of the epithelial cell line A431 in culture.; FUNCTION: [Granulin-3]: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. {ECO:0000269|PubMed:12526812}.; FUNCTION: [Granulin-7]: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity. {ECO:0000269|PubMed:28453791}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for GRN-IGFBP5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for GRN-IGFBP5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for GRN-IGFBP5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for GRN-IGFBP5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GRN | C0011570 | Mental Depression | 3 | PSYGENET |
| Hgene | GRN | C0011581 | Depressive disorder | 3 | PSYGENET |
| Hgene | GRN | C0338451 | Frontotemporal dementia | 3 | CTD_human;GENOMICS_ENGLAND |
| Hgene | GRN | C0338462 | Semantic Dementia | 3 | CTD_human;ORPHANET |
| Hgene | GRN | C1843792 | FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED | 3 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Hgene | GRN | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Hgene | GRN | C0036341 | Schizophrenia | 2 | PSYGENET |
| Hgene | GRN | C0338630 | Senile Paranoid Dementia | 2 | CTD_human |
| Hgene | GRN | C0497327 | Dementia | 2 | CTD_human |
| Hgene | GRN | C0751071 | Familial Dementia | 2 | CTD_human |
| Hgene | GRN | C4011788 | Behavioral variant of frontotemporal dementia | 2 | ORPHANET |
| Hgene | GRN | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | GRN | C0027746 | Nerve Degeneration | 1 | CTD_human |
| Hgene | GRN | C0751072 | Frontotemporal Lobar Degeneration | 1 | CTD_human |
| Hgene | GRN | C0751706 | Primary Progressive Nonfluent Aphasia | 1 | ORPHANET |
| Hgene | GRN | C3539123 | CEROID LIPOFUSCINOSIS, NEURONAL, 11 | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
| Tgene | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human | |
| Tgene | C0005695 | Bladder Neoplasm | 1 | CTD_human | |
| Tgene | C0006142 | Malignant neoplasm of breast | 1 | CTD_human | |
| Tgene | C0043094 | Weight Gain | 1 | CTD_human | |
| Tgene | C0678222 | Breast Carcinoma | 1 | CTD_human | |
| Tgene | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human | |
| Tgene | C1458155 | Mammary Neoplasms | 1 | CTD_human | |
| Tgene | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
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