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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GSTT1-TMEM189 (FusionGDB2 ID:HG2952TG387521)

Fusion Gene Summary for GSTT1-TMEM189

check button Fusion gene summary
Fusion gene informationFusion gene name: GSTT1-TMEM189
Fusion gene ID: hg2952tg387521
HgeneTgene
Gene symbol

GSTT1

TMEM189

Gene ID

2952

387521

Gene nameglutathione S-transferase theta 1transmembrane protein 189
Synonyms-CarF|KUA
Cytomap('GSTT1')('TMEM189')

22q11.23

20q13.13

Type of geneprotein-codingprotein-coding
Descriptionglutathione S-transferase theta-1GST class-theta-1glutathione transferase T1-1transmembrane protein 189
Modification date2020031520200313
UniProtAcc

P30711

.
Ensembl transtripts involved in fusion geneENST00000248935, ENST00000439996, 
Fusion gene scores* DoF score4 X 2 X 3=244 X 3 X 4=48
# samples 34
** MAII scorelog2(3/24*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GSTT1 [Title/Abstract] AND TMEM189 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGSTT1(24384120)-TMEM189(48700791), # samples:1
Anticipated loss of major functional domain due to fusion event.GSTT1-TMEM189 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GSTT1-TMEM189 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GSTT1-TMEM189 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GSTT1-TMEM189 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGSTT1

GO:0006749

glutathione metabolic process

9307035|9434735|20097269

TgeneTMEM189

GO:0008611

ether lipid biosynthetic process

31604315


check buttonFusion gene breakpoints across GSTT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TMEM189 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-AAE2GSTT1chr22

24384120

-TMEM189chr20

48700791

-


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Fusion Gene ORF analysis for GSTT1-TMEM189

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000248935ENST00000371650GSTT1chr22

24384120

-TMEM189chr20

48700791

-
5CDS-intronENST00000248935ENST00000371652GSTT1chr22

24384120

-TMEM189chr20

48700791

-
5CDS-intronENST00000248935ENST00000371656GSTT1chr22

24384120

-TMEM189chr20

48700791

-
5UTR-3CDSENST00000439996ENST00000557021GSTT1chr22

24384120

-TMEM189chr20

48700791

-
5UTR-intronENST00000439996ENST00000371650GSTT1chr22

24384120

-TMEM189chr20

48700791

-
5UTR-intronENST00000439996ENST00000371652GSTT1chr22

24384120

-TMEM189chr20

48700791

-
5UTR-intronENST00000439996ENST00000371656GSTT1chr22

24384120

-TMEM189chr20

48700791

-
In-frameENST00000248935ENST00000557021GSTT1chr22

24384120

-TMEM189chr20

48700791

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000248935GSTT1chr2224384120-ENST00000557021TMEM189chr2048700791-20801651227877116

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000248935ENST00000557021GSTT1chr2224384120-TMEM189chr2048700791-0.825688840.17431113

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Fusion Genomic Features for GSTT1-TMEM189


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for GSTT1-TMEM189


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:24384120/chr20:48700791)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSTT1

P30711

.
FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide. {ECO:0000269|PubMed:16298388, ECO:0000269|PubMed:20097269}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMEM189chr22:24384120chr20:48700791ENST0000037165206186_1900271.0MotifHistidine box-1
TgeneTMEM189chr22:24384120chr20:48700791ENST0000037165206213_2170271.0MotifHistidine box-2
TgeneTMEM189chr22:24384120chr20:48700791ENST0000037165206161_1810271.0TransmembraneHelical
TgeneTMEM189chr22:24384120chr20:48700791ENST000003716520647_670271.0TransmembraneHelical
TgeneTMEM189chr22:24384120chr20:48700791ENST000003716520674_940271.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGSTT1chr22:24384120chr20:48700791ENST00000248935-152_8237241.0DomainNote=GST N-terminal
HgeneGSTT1chr22:24384120chr20:48700791ENST00000248935-1588_22037241.0DomainNote=GST C-terminal
HgeneGSTT1chr22:24384120chr20:48700791ENST00000248935-1553_5437241.0RegionGlutathione binding
HgeneGSTT1chr22:24384120chr20:48700791ENST00000248935-1566_6737241.0RegionGlutathione binding


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Fusion Gene Sequence for GSTT1-TMEM189


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>35148_35148_1_GSTT1-TMEM189_GSTT1_chr22_24384120_ENST00000248935_TMEM189_chr20_48700791_ENST00000557021_length(transcript)=2080nt_BP=165nt
ACTGGAGTTTGCTGACTCCCTCTGGTTTCCGGTCAGGTCGGTCGGTCCCCACTATGGGCCTGGAGCTGTACCTGGACCTGCTGTCCCAGC
CCTGCCGCGCTGTTTACATCTTTGCCAAGAAGAACGACATTCCCTTCGAGCTGCGCATCGTGGATCTGATTAAAGACAATTTATGAAAAC
CGAATATACAGCCTTAAAATAGAATGTGGACCTAAATACCCAGAAGCACCCCCCTTTGTAAGATTTGTAACAAAAATTAATATGAATGGA
GTAAATAGTTCTAATGGAGTGGTGGACCCAAGAGCCATATCAGTGCTAGCAAAATGGCAGAATTCATATAGCATCAAAGTTGTCCTGCAA
GAGCTTCGGCGCCTAATGATGTCTAAAGAAAATATGAAACTCCCTCAGCCGCCCGAAGGACAGTGTTACAGCAATTAATCAAAAAGAAAA
ACCACAGGCCCTTCCCCTTCCCCCCAATTCGATTTAATCAGTCTTCATTTTCCACAGTAGTAAATTTTCTAGATACGTCTTGTAGACCTC
AAAGTACCGGAAAGGAAGCTCCCATTCAAAGGAAATTTATCTTAAGATACTGTAAATGATACTAATTTTTTGTCCATTTGAAATATATAA
GTTGTGCTATAACAAATCATCCTGTCAAGTGTAACCACTGTCCACGTAGTTGAACTTCTGGGATCAAGAAAGTCTATTTAAATTGATTCC
CATCATAACTGGTGGGGCACATCTAACTCAACTGTGAAAAGACACATCACACAATCACCTTGCTGCTGATTACACGGCCTGGGGTCTCTG
CCTTCTCCCCTTACCCTCCCGCCTCCCACCCTCCCTGCAACAACAGCCCTCTAGCCTGGGGGGCTTGTTAGAGTAGATGTGAAGGTTTCA
GGTCGCAGCCTGTGGGACTACTGCTAGGTGTGTGGGGTGTTTCGCCTGCACCCCTGGTTTCTTTAAGTCTTAAGTGATGCCCCTTCCAAA
CCATCATCCTGTCCCCACGCTCCTCCACTCCCGCCCTTGGCCGAAGCATAGATTGTAACCCCTCCACTCCCCTCTGAGATTGGCCTTCGG
TGAGGAATTCAGGGCTTTCCCCATATCTTCTCTCCCCCACCTTTATCGAGGGGTGCTGCTTTTTCTCCCTCCTCCTCAAGTTCCTTTTTG
CACCGTCACCACCCAACACCTTCCATGACACTTCCTTGCTTTGGCCAGAAGCCATCAGGTAAGGTTGGAAAGAGCCTCTGACCTCCCTTG
TTTAGTTTTGGAACCATACTCACTCACTCTCCACCAGCCTGGGAAATGAATATTGGGTCCTCAGCCCTGCCACCCTCTGCTGTCATCAGC
TGATGCATTGTTTTTAGCTCAGGTTTTGATAAGGTGAAAAGAATAGTCACCAGGGTTACTCAGACCTGCCAGCTCTCGGAGTCCTTGGTG
GTTGAACTTGGAGAAAGACCGCATGAAGATACTTGTAAGCACACATGATCCCTCTGAATTGTTTTACTTTCCTGTAACTGCTTTTGCTTT
TAAAAATTGAAGAAGTTTTAAACAGGGCTTTCATTTGGTCATCCTTGCAATCCATTGGGGTCTAGTTTGGAATCTGACAACTGGAACAAA
AAGAACCTTGAATCCGGTGCATGCCTTGGTTTTGGTGCTGCTGCTGCTTCCCAAGATCCTCAGCAGGGATTAAGAAGGAACCCGGTGTGC
ACAGCAGATCCCCGAAATTGGTGGGCTTGACCTCCTGGCAAATTGCTGCGTCTTTCCACTTGCTGTTCAGGACCACTAAATGCTGAAATG
TGGATGCATACCGAAATAAAAGCAATTCATTGTGTACTAAAGGTTTTTTTTTTTTTTTTAATTTAGTATTTGTGTAAAACCACCTTTTGA
AGCAGCAACTATCAAGTCTGAAAAGCAATTGATGTTTCCATTAATCTTTTTCTGGGGGGAAAACCTTAGTTCTAAGGATTTAACATCCTG
TAAGTGAAGTTTAACATAACAGTATTCCATAAGCAGCCTTTTTATTGTCAGACCATTGCCTGATTTTAATATAATAAAAAAAAAGTGTGC

>35148_35148_1_GSTT1-TMEM189_GSTT1_chr22_24384120_ENST00000248935_TMEM189_chr20_48700791_ENST00000557021_length(amino acids)=116AA_BP=
MMASGQSKEVSWKVLGGDGAKRNLRRREKKQHPSIKVGERRYGESPEFLTEGQSQRGVEGLQSMLRPRAGVEERGDRMMVWKGHHLRLKE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GSTT1-TMEM189


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GSTT1-TMEM189


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGSTT1P30711DB00143GlutathioneSmall moleculeApproved|Investigational|Nutraceutical

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Related Diseases for GSTT1-TMEM189


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGSTT1C0036341Schizophrenia5PSYGENET
HgeneGSTT1C0033578Prostatic Neoplasms4CTD_human
HgeneGSTT1C0376358Malignant neoplasm of prostate4CTD_human
HgeneGSTT1C0004403Autosome Abnormalities3CTD_human
HgeneGSTT1C0008625Chromosome Aberrations3CTD_human
HgeneGSTT1C0019193Hepatitis, Toxic3CTD_human
HgeneGSTT1C0860207Drug-Induced Liver Disease3CTD_human
HgeneGSTT1C1262760Hepatitis, Drug-Induced3CTD_human
HgeneGSTT1C3658290Drug-Induced Acute Liver Injury3CTD_human
HgeneGSTT1C4277682Chemical and Drug Induced Liver Injury3CTD_human
HgeneGSTT1C4279912Chemically-Induced Liver Toxicity3CTD_human
HgeneGSTT1C0007134Renal Cell Carcinoma2CTD_human
HgeneGSTT1C0236733Amphetamine-Related Disorders2CTD_human
HgeneGSTT1C0236804Amphetamine Addiction2CTD_human
HgeneGSTT1C0236807Amphetamine Abuse2CTD_human
HgeneGSTT1C0279702Conventional (Clear Cell) Renal Cell Carcinoma2CTD_human
HgeneGSTT1C1266042Chromophobe Renal Cell Carcinoma2CTD_human
HgeneGSTT1C1266043Sarcomatoid Renal Cell Carcinoma2CTD_human
HgeneGSTT1C1266044Collecting Duct Carcinoma of the Kidney2CTD_human
HgeneGSTT1C1306837Papillary Renal Cell Carcinoma2CTD_human
HgeneGSTT1C0003949Asbestosis1CTD_human
HgeneGSTT1C0005586Bipolar Disorder1PSYGENET
HgeneGSTT1C0006826Malignant Neoplasms1CTD_human
HgeneGSTT1C0007097Carcinoma1CTD_human
HgeneGSTT1C0007114Malignant neoplasm of skin1CTD_human
HgeneGSTT1C0011570Mental Depression1PSYGENET
HgeneGSTT1C0011581Depressive disorder1PSYGENET
HgeneGSTT1C0017636Glioblastoma1CTD_human
HgeneGSTT1C0020538Hypertensive disease1CTD_human
HgeneGSTT1C0022665Kidney Neoplasm1CTD_human
HgeneGSTT1C0024121Lung Neoplasms1CTD_human
HgeneGSTT1C0026764Multiple Myeloma1CTD_human
HgeneGSTT1C0027651Neoplasms1CTD_human
HgeneGSTT1C0034734Raynaud Disease1CTD_human
HgeneGSTT1C0034735Raynaud Phenomenon1CTD_human
HgeneGSTT1C0037286Skin Neoplasms1CTD_human
HgeneGSTT1C0086692Benign Neoplasm1CTD_human
HgeneGSTT1C0205696Anaplastic carcinoma1CTD_human
HgeneGSTT1C0205697Carcinoma, Spindle-Cell1CTD_human
HgeneGSTT1C0205698Undifferentiated carcinoma1CTD_human
HgeneGSTT1C0205699Carcinomatosis1CTD_human
HgeneGSTT1C0242379Malignant neoplasm of lung1CTD_human
HgeneGSTT1C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneGSTT1C0334588Giant Cell Glioblastoma1CTD_human
HgeneGSTT1C0400966Non-alcoholic Fatty Liver Disease1CTD_human
HgeneGSTT1C0403823Asthenozoospermia1CTD_human
HgeneGSTT1C0740457Malignant neoplasm of kidney1CTD_human
HgeneGSTT1C1449861Micronuclei, Chromosome-Defective1CTD_human
HgeneGSTT1C1449862Micronuclei, Genotoxicant-Induced1CTD_human
HgeneGSTT1C1621958Glioblastoma Multiforme1CTD_human
HgeneGSTT1C2930617Pulmonary Fibrosis - from Asbestos Exposure1CTD_human
HgeneGSTT1C3241937Nonalcoholic Steatohepatitis1CTD_human