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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NRBP1-IGHG1 (FusionGDB2 ID:HG29959TG3500)

Fusion Gene Summary for NRBP1-IGHG1

check button Fusion gene summary
Fusion gene informationFusion gene name: NRBP1-IGHG1
Fusion gene ID: hg29959tg3500
HgeneTgene
Gene symbol

NRBP1

IGHG1

Gene ID

29959

3500

Gene namenuclear receptor binding protein 1
SynonymsBCON3|MADM|MUDPNP|NRBP
Cytomap('NRBP1')('IGHG1')

2p23.3

Type of geneprotein-coding
Descriptionnuclear receptor-binding proteinmultiple domain putative nuclear proteinmyeloid leukemia factor 1 adaptor molecule
Modification date20200329
UniProtAcc.

P01857

Ensembl transtripts involved in fusion geneENST00000233557, ENST00000379852, 
ENST00000379863, 
Fusion gene scores* DoF score10 X 9 X 8=72095 X 52 X 17=83980
# samples 13116
** MAII scorelog2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(116/83980*10)=-6.17784907770745
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NRBP1 [Title/Abstract] AND IGHG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNRBP1(27664675)-IGHG1(106209409), # samples:5
Anticipated loss of major functional domain due to fusion event.NRBP1-IGHG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NRBP1-IGHG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NRBP1-IGHG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NRBP1-IGHG1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NRBP1-IGHG1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
NRBP1-IGHG1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNRBP1

GO:0006888

ER to Golgi vesicle-mediated transport

11956649


check buttonFusion gene breakpoints across NRBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across IGHG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CR-7379NRBP1chr2

27664675

+IGHG1chr14

106209409

-
ChimerDB4HNSCTCGA-CR-7379NRBP1chr2

27664675

+IGHG1chr14

106237744

-
ChimerDB4LUSCTCGA-22-1011NRBP1chr2

27664675

+IGHG1chr14

106209409

-
ChimerDB4LUSCTCGA-33-A4WNNRBP1chr2

27664677

+IGHG1chr14

106209407

-
ChimerDB4LUSCTCGA-60-2709NRBP1chr2

27664674

+IGHG1chr14

106209410

-
ChimerDB4LUSCTCGA-66-2795NRBP1chr2

27664677

+IGHG1chr14

106209407

-
ChimerDB4LUSCTCGA-85-8276NRBP1chr2

27664675

+IGHG1chr14

106209409

-
ChimerDB4LUSCTCGA-85-8276NRBP1chr2

27664675

+IGHG1chr14

106237744

-
ChimerDB4LUSCTCGA-85-8353NRBP1chr2

27664675

+IGHG1chr14

106209409

-
ChimerDB4LUSCTCGA-92-8064NRBP1chr2

27664675

+IGHG1chr14

106209409

-
ChimerDB4SKCMTCGA-FS-A1ZT-06ANRBP1chr2

27664674

+IGHG1chr14

106209410

-
ChimerDB4THCATCGA-EM-A2CP-01ANRBP1chr2

27664674

+IGHG1chr14

106209410

-


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Fusion Gene ORF analysis for NRBP1-IGHG1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000233557ENST00000390548NRBP1chr2

27664675

+IGHG1chr14

106237744

-
5CDS-intronENST00000379852ENST00000390548NRBP1chr2

27664675

+IGHG1chr14

106237744

-
5CDS-intronENST00000379863ENST00000390548NRBP1chr2

27664675

+IGHG1chr14

106237744

-
Frame-shiftENST00000379852ENST00000390548NRBP1chr2

27664675

+IGHG1chr14

106209409

-
Frame-shiftENST00000379852ENST00000390548NRBP1chr2

27664677

+IGHG1chr14

106209407

-
Frame-shiftENST00000379852ENST00000390548NRBP1chr2

27664674

+IGHG1chr14

106209410

-
Frame-shiftENST00000379863ENST00000390548NRBP1chr2

27664675

+IGHG1chr14

106209409

-
Frame-shiftENST00000379863ENST00000390548NRBP1chr2

27664677

+IGHG1chr14

106209407

-
Frame-shiftENST00000379863ENST00000390548NRBP1chr2

27664674

+IGHG1chr14

106209410

-
In-frameENST00000233557ENST00000390548NRBP1chr2

27664675

+IGHG1chr14

106209409

-
In-frameENST00000233557ENST00000390548NRBP1chr2

27664677

+IGHG1chr14

106209407

-
In-frameENST00000233557ENST00000390548NRBP1chr2

27664674

+IGHG1chr14

106209410

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000233557NRBP1chr227664675+ENST00000390548IGHG1chr14106209409-540527865082361617
ENST00000233557NRBP1chr227664677+ENST00000390548IGHG1chr14106209407-540327845082595695
ENST00000233557NRBP1chr227664674+ENST00000390548IGHG1chr14106209410-540627875082598696

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000233557ENST00000390548NRBP1chr227664675+IGHG1chr14106209409-0.0064102470.99358976
ENST00000233557ENST00000390548NRBP1chr227664677+IGHG1chr14106209407-0.0058054850.99419457
ENST00000233557ENST00000390548NRBP1chr227664674+IGHG1chr14106209410-0.0057333170.9942667

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Fusion Genomic Features for NRBP1-IGHG1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for NRBP1-IGHG1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:27664675/chr14:106209409)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IGHG1

P01857

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNRBP1chr2:27664674chr14:106209410ENST00000233557+11968_3270536.0DomainProtein kinase
HgeneNRBP1chr2:27664674chr14:106209410ENST00000379852+11868_3270536.0DomainProtein kinase
HgeneNRBP1chr2:27664675chr14:106209409ENST00000233557+11968_3270536.0DomainProtein kinase
HgeneNRBP1chr2:27664675chr14:106209409ENST00000379852+11868_3270536.0DomainProtein kinase
HgeneNRBP1chr2:27664677chr14:106209407ENST00000233557+11968_3270536.0DomainProtein kinase
HgeneNRBP1chr2:27664677chr14:106209407ENST00000379852+11868_3270536.0DomainProtein kinase


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Fusion Gene Sequence for NRBP1-IGHG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NRBP1-IGHG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NRBP1-IGHG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneIGHG1P01857DB09130CopperSmall moleculeApproved|Investigational

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Related Diseases for NRBP1-IGHG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0027121Myositis1CTD_human
TgeneC0032460Polycystic Ovary Syndrome1CTD_human
TgeneC0158353Infectious Myositis1CTD_human
TgeneC0544796Myositis, Proliferative1CTD_human
TgeneC0751356Idiopathic Inflammatory Myopathies1CTD_human
TgeneC0751357Myositis, Focal1CTD_human
TgeneC1136382Sclerocystic Ovaries1CTD_human