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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HCFC1-EPHA5 (FusionGDB2 ID:HG3054TG2044)

Fusion Gene Summary for HCFC1-EPHA5

check button Fusion gene summary
Fusion gene informationFusion gene name: HCFC1-EPHA5
Fusion gene ID: hg3054tg2044
HgeneTgene
Gene symbol

HCFC1

EPHA5

Gene ID

3054

2044

Gene namehost cell factor C1EPH receptor A5
SynonymsCFF|HCF|HCF-1|HCF1|HFC1|MRX3|PPP1R89|VCAFCEK7|EHK-1|EHK1|EK7|HEK7|TYRO4
Cytomap('HCFC1')('EPHA5')

Xq28

4q13.1-q13.2

Type of geneprotein-codingprotein-coding
Descriptionhost cell factor 1VP16-accessory proteinprotein phosphatase 1, regulatory subunit 89ephrin type-A receptor 5EPH homology kinase 1EPH-like kinase 7brain-specific kinaseepididymis secretory sperm binding proteinreceptor protein-tyrosine kinase HEK7tyrosine-protein kinase receptor EHK-1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000310441, ENST00000354233, 
ENST00000369984, ENST00000461098, 
Fusion gene scores* DoF score16 X 17 X 8=21766 X 5 X 3=90
# samples 255
** MAII scorelog2(25/2176*10)=-3.12167855658825
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HCFC1 [Title/Abstract] AND EPHA5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHCFC1(153236099)-EPHA5(66189937), # samples:3
Anticipated loss of major functional domain due to fusion event.HCFC1-EPHA5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HCFC1-EPHA5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HCFC1-EPHA5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HCFC1-EPHA5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HCFC1-EPHA5 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
HCFC1-EPHA5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HCFC1-EPHA5 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
HCFC1-EPHA5 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHCFC1

GO:0006355

regulation of transcription, DNA-templated

12670868

HgeneHCFC1

GO:0010628

positive regulation of gene expression

21285374

HgeneHCFC1

GO:0043254

regulation of protein complex assembly

10675337

HgeneHCFC1

GO:0043981

histone H4-K5 acetylation

20018852

HgeneHCFC1

GO:0043982

histone H4-K8 acetylation

20018852

HgeneHCFC1

GO:0043984

histone H4-K16 acetylation

20018852

HgeneHCFC1

GO:0050821

protein stabilization

21285374


check buttonFusion gene breakpoints across HCFC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across EPHA5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-LA-A446-01AHCFC1chrX

153236099

-EPHA5chr4

66189937

-
ChimerDB4LUSCTCGA-LA-A446HCFC1chrX

153236099

-EPHA5chr4

66189937

-


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Fusion Gene ORF analysis for HCFC1-EPHA5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000310441ENST00000511294HCFC1chrX

153236099

-EPHA5chr4

66189937

-
5CDS-intronENST00000354233ENST00000511294HCFC1chrX

153236099

-EPHA5chr4

66189937

-
5CDS-intronENST00000369984ENST00000511294HCFC1chrX

153236099

-EPHA5chr4

66189937

-
Frame-shiftENST00000310441ENST00000432638HCFC1chrX

153236099

-EPHA5chr4

66189937

-
Frame-shiftENST00000354233ENST00000432638HCFC1chrX

153236099

-EPHA5chr4

66189937

-
Frame-shiftENST00000369984ENST00000432638HCFC1chrX

153236099

-EPHA5chr4

66189937

-
In-frameENST00000310441ENST00000273854HCFC1chrX

153236099

-EPHA5chr4

66189937

-
In-frameENST00000310441ENST00000354839HCFC1chrX

153236099

-EPHA5chr4

66189937

-
In-frameENST00000354233ENST00000273854HCFC1chrX

153236099

-EPHA5chr4

66189937

-
In-frameENST00000354233ENST00000354839HCFC1chrX

153236099

-EPHA5chr4

66189937

-
In-frameENST00000369984ENST00000273854HCFC1chrX

153236099

-EPHA5chr4

66189937

-
In-frameENST00000369984ENST00000354839HCFC1chrX

153236099

-EPHA5chr4

66189937

-
intron-3CDSENST00000461098ENST00000273854HCFC1chrX

153236099

-EPHA5chr4

66189937

-
intron-3CDSENST00000461098ENST00000354839HCFC1chrX

153236099

-EPHA5chr4

66189937

-
intron-3CDSENST00000461098ENST00000432638HCFC1chrX

153236099

-EPHA5chr4

66189937

-
intron-intronENST00000461098ENST00000511294HCFC1chrX

153236099

-EPHA5chr4

66189937

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000310441HCFC1chrX153236099-ENST00000273854EPHA5chr466189937-581711601014406202
ENST00000310441HCFC1chrX153236099-ENST00000354839EPHA5chr466189937-145211601014406202
ENST00000369984HCFC1chrX153236099-ENST00000273854EPHA5chr466189937-5194537648259129
ENST00000369984HCFC1chrX153236099-ENST00000354839EPHA5chr466189937-829537648259129
ENST00000354233HCFC1chrX153236099-ENST00000273854EPHA5chr466189937-5378721832443129
ENST00000354233HCFC1chrX153236099-ENST00000354839EPHA5chr466189937-1013721832443129

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000310441ENST00000273854HCFC1chrX153236099-EPHA5chr466189937-0.793269630.20673038
ENST00000310441ENST00000354839HCFC1chrX153236099-EPHA5chr466189937-0.449187460.5508126
ENST00000369984ENST00000273854HCFC1chrX153236099-EPHA5chr466189937-0.80264040.1973596
ENST00000369984ENST00000354839HCFC1chrX153236099-EPHA5chr466189937-0.463554020.536446
ENST00000354233ENST00000273854HCFC1chrX153236099-EPHA5chr466189937-0.797643840.20235611
ENST00000354233ENST00000354839HCFC1chrX153236099-EPHA5chr466189937-0.439713180.5602869

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Fusion Genomic Features for HCFC1-EPHA5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for HCFC1-EPHA5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:153236099/chr4:66189937)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEPHA5chrX:153236099chr4:66189937ENST0000027385416181035_103710021038.0MotifPDZ-binding
TgeneEPHA5chrX:153236099chr4:66189937ENST0000035483915171035_10379801016.0MotifPDZ-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-1261797_1888642036.0DomainFibronectin type-III 2
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-1261890_2006642036.0DomainFibronectin type-III 3
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-126366_466642036.0DomainFibronectin type-III 1
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-1271797_1888641967.0DomainFibronectin type-III 2
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-1271890_2006641967.0DomainFibronectin type-III 3
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-127366_466641967.0DomainFibronectin type-III 1
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-1261010_1035642036.0RepeatNote=HCF repeat 1
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-1261072_1097642036.0RepeatNote=HCF repeat 2
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-1261101_1126642036.0RepeatNote=HCF repeat 3
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-1261158_1183642036.0RepeatNote=HCF repeat 4%3B degenerate
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-1261286_1311642036.0RepeatNote=HCF repeat 5
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-1261314_1339642036.0RepeatNote=HCF repeat 6
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-1261349_1374642036.0RepeatNote=HCF repeat 7%3B degenerate
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-1261414_1439642036.0RepeatNote=HCF repeat 8
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-126148_194642036.0RepeatNote=Kelch 3
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-126217_265642036.0RepeatNote=Kelch 4
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-126266_313642036.0RepeatNote=Kelch 5
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-12644_89642036.0RepeatNote=Kelch 1
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-12693_140642036.0RepeatNote=Kelch 2
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-1271010_1035641967.0RepeatNote=HCF repeat 1
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-1271072_1097641967.0RepeatNote=HCF repeat 2
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-1271101_1126641967.0RepeatNote=HCF repeat 3
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-1271158_1183641967.0RepeatNote=HCF repeat 4%3B degenerate
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-1271286_1311641967.0RepeatNote=HCF repeat 5
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-1271314_1339641967.0RepeatNote=HCF repeat 6
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-1271349_1374641967.0RepeatNote=HCF repeat 7%3B degenerate
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-1271414_1439641967.0RepeatNote=HCF repeat 8
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-127148_194641967.0RepeatNote=Kelch 3
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-127217_265641967.0RepeatNote=Kelch 4
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-127266_313641967.0RepeatNote=Kelch 5
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-12744_89641967.0RepeatNote=Kelch 1
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-12793_140641967.0RepeatNote=Kelch 2
TgeneEPHA5chrX:153236099chr4:66189937ENST000002738541618220_35410021038.0Compositional biasNote=Cys-rich
TgeneEPHA5chrX:153236099chr4:66189937ENST000003548391517220_3549801016.0Compositional biasNote=Cys-rich
TgeneEPHA5chrX:153236099chr4:66189937ENST000002738541618357_46710021038.0DomainFibronectin type-III 1
TgeneEPHA5chrX:153236099chr4:66189937ENST000002738541618468_56210021038.0DomainFibronectin type-III 2
TgeneEPHA5chrX:153236099chr4:66189937ENST00000273854161860_23810021038.0DomainEph LBD
TgeneEPHA5chrX:153236099chr4:66189937ENST000002738541618675_93610021038.0DomainProtein kinase
TgeneEPHA5chrX:153236099chr4:66189937ENST000002738541618965_102910021038.0DomainSAM
TgeneEPHA5chrX:153236099chr4:66189937ENST000003548391517357_4679801016.0DomainFibronectin type-III 1
TgeneEPHA5chrX:153236099chr4:66189937ENST000003548391517468_5629801016.0DomainFibronectin type-III 2
TgeneEPHA5chrX:153236099chr4:66189937ENST00000354839151760_2389801016.0DomainEph LBD
TgeneEPHA5chrX:153236099chr4:66189937ENST000003548391517675_9369801016.0DomainProtein kinase
TgeneEPHA5chrX:153236099chr4:66189937ENST000003548391517965_10299801016.0DomainSAM
TgeneEPHA5chrX:153236099chr4:66189937ENST000002738541618681_68910021038.0Nucleotide bindingATP
TgeneEPHA5chrX:153236099chr4:66189937ENST000003548391517681_6899801016.0Nucleotide bindingATP
TgeneEPHA5chrX:153236099chr4:66189937ENST00000273854161825_57310021038.0Topological domainExtracellular
TgeneEPHA5chrX:153236099chr4:66189937ENST000002738541618595_103710021038.0Topological domainCytoplasmic
TgeneEPHA5chrX:153236099chr4:66189937ENST00000354839151725_5739801016.0Topological domainExtracellular
TgeneEPHA5chrX:153236099chr4:66189937ENST000003548391517595_10379801016.0Topological domainCytoplasmic
TgeneEPHA5chrX:153236099chr4:66189937ENST000002738541618574_59410021038.0TransmembraneHelical
TgeneEPHA5chrX:153236099chr4:66189937ENST000003548391517574_5949801016.0TransmembraneHelical


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Fusion Gene Sequence for HCFC1-EPHA5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>35729_35729_1_HCFC1-EPHA5_HCFC1_chrX_153236099_ENST00000310441_EPHA5_chr4_66189937_ENST00000273854_length(transcript)=5817nt_BP=1160nt
CGGCTCCCAGGGAGGAGGCATGAGCGCCCTGCCGTTACCGCTTCTTCTGCCGTACAGTTGCCGCTTCGGGGCCTAACTCTAGCTCTTTGA
AGCGGCTCCTGTGGGAAGGAGTCATAAGGCGGGAAGTGAGGATCGGACACCGCCTTGAGTTTGGTGTGCAGTGGAAGAACTGACCTAGGA
GGAAGAGAATAGGGGGGAACGGGGAGCTAGTCTCAAGATGGCGGCTCCCACGGCGGCAGGCGCAGCCTGAGCAGCAGAGGCGGACTAAGG
GGAGAGGCGCGAGACTTCACAAGCCGTACGGCGCGAGCCCCCAAACGGCCCTCGAGAGCTCGAGCTGGTTCCACCGGCCTCCGGCCCGCC
TCCATTCGTTAGGTGTGTCGAGGCTGTTTCGGGAGCGGCGGCTGCACTAAGGCGCTGGGCGGGGAAGCGGGACGGTCTCAAGATGGCGGC
TCCCACAATTGTGGTCTGAGCGCCGGCGGGGCTGCGACGACCGCGGCGCTTGTGGCTCCTTTCCACCCGCCCCGGAAGCCGGCCAGTGCT
GGGGACTTGGGGGTGTGGGAACCGGGCCGGGGCTCCGCCATTTCCGGCGGGGGAGGGCTACGACTGAGGAAGGGAGGAGAGAGAGGCGGC
TCAAGATGGCGGCTCCCAGGGCCTCCCGCCCGAGCTTGTAAGCGGGAGCGCCCGGACAAGTAGTCGGGGCGACGGGACTCAGCGGCCTCC
AGCTTCTTGAGCCTAGGCGCTCGACAGTTTCGGGCGGCTCTTGCGGAGACGGGGTGAGCGAGAAGAAAGGGAAGAGCCAAAGGGAAGGAG
GGCAGTTAAGATGGCGGCCTCCATGGAGTCGTCTACCGCTGTGTGAGAAACCGCTTCTCCGTGAGAGCTGCCTTAGACGAAAGGGGGTGT
GTGAAAGGAATTGAGGGGCTCCCTTCCCGCTTGTTGACTTCTCCCCACCGCACCCTTTCCCGGAACTATGGCTTCGGCCGTGTCGCCCGC
CAACTTGCCAGCGGTGCTTCTGCAGCCCCGCTGGAAGCGAGTGGTGGGCTGGTCGGGTCCGGTGCCACGGCCCCGCCACGGCCACCGCGC
CGTGGCCATCAAGGAGCTCATCGTGGTGTTTGGCGGCGGCAACGAGGGAATAGTGGACGAACTGCACGTGTACAACACGGGGATTTGAGA
CGGCTTGGAGTGACTCTTGTCGGTCACCAGAAGAAGATCATGAACAGCCTTCAAGAAATGAAGGTGCAGCTGGTAAACGGAATGGTGCCA
TTGTAACTTCATGTAAATGTCGCTTCTTCAAGTGAATGATTCTGCACTTTGTAAACAGCACTGAGATTTATTTTAACAAAAAAAGGGGGA
AAAGGGAAAACAGTGATTTCTAAACCTTAGAAAACATTTGCCTCAGCCACAGAATTTGTAATCATGGTTTTACTGAAGTATCCAGTTCTT
AGTCCTTAGTCTTCATTTTTCATGAAGCAAACATATCTTGCATTAAAAGGGACATGAAGTTAGACATCATCTTAAGTTACAACAACAGAA
TCCTTCCCACTACTTCTACAAAATTTTGTACATGAAATATATAATTATATAGCACTTTTATAGACTGAATTAAGGCAACCCCTTTCAAAA
CTTCCAGGGATCTACTTGAAAGGAAATGTTTTATAGCCATTTGTGAGCTAACAAAAGCTACAGTTTACTGAAGTTTACTTCAAGTCTTAA
TTGTCTACAAAAGTGTATTGAAGAGCAATATGATTAGATTATTTCTTAATAGATATCTTCTTTTGTAATTTTAAAATGCTGTTACACAGC
GTTAAGTTATAGAAACTAGTGTGTAAACATGTTGCTTGATCAAGAAAAAGTACAATACAGGGTGTATATTTATTTTTTGTGTTATAAAGT
TTACTTTTAGTTGCTCTTCTAGAGATTATTAGGTAATAAATGTGTATATACTGTATAATTTGCAATATACCCAGGAACTGATTTAAGATG
GAATTGTGTGTGTGTTTGCTTGCACATGTGTGTGTTACCATTCTGCTTGCATTTCTAATAGTGTTTCAATTTTAGCAACATATAGGAGCA
AGTGTTCCAGAATGTAATATGAATAGGAGAAATAGGGAAGCAGTAAAACAAAATTTAACACAAGCTTGTGTCTCTTTTCCTCTCATGTGT
CCAAAAGCTAATCTCTTTATTCACTAAAAGGAAATGTGTATAAGACTAAATCCCCTTTGGCTTTTTAAAAACATTTTGTGATATCAGTGA
CAATGCAGTTCTTCTAGCCATTAATCTTGTACCCCTGTAAGAAATTTCACCTTTCTGAGTCCTGAAAAGTATCTTGTCAAGCAAAGTTGA
CACCGAAGGGCACATTTTCAGCAGGATGTAGAAGGATTTAACTGTGCAGGCTTCTGTTAATGTTGTTAAATCCAGGCACATAGCACGAAG
CATCACCCTTAAGTGTTAATCCGTTGTAACCATTCCCATTTTGACTCAGTTCTAGAAATTTTGACTCTAAGGCAGCAATGGAATTATGAC
AAATATATATATATACACATACACACACACAAATATATATATATGCTTATTTCCCTTCAGAATTTTATTTCAATAATTGATAAGTTTTAT
TTTTAATGGATGTTTATTCATTTGTTAATTTCAGTTTGTATTCAGTTACATGGCTTTGAGTTTATTTTATTGAACCAATCCAAGGTATTA
TGTAATTAGGCTTATTAAGGAATATAACATATCTTCTATGTATGCTCTATATACCACACATGATGAAGACTTATATTTGTGATACAAATT
ATGCAGTGTATTAGAAATTGTCCAAAACTGAGCTCCTGAGATAACCAACATTTTTGTATTATTACACTTTATAAAAATTATGGAATGTCA
TGTGATTAGTCAAAATCAGAGCATTTAAATAAAATACAGCCTACTCATGATTATCAATGTTAATAGTACAGTAGATCAGAGAAGCCTGGA
TTAATGAAATTTATCAGAAATATAGCCACGTTATATTAATGGTATTCTTTTTTCCAAGCACTTGTTTTATTTGAATATTAGCACATATAA
GAATAAACTTTTGGGAAATAACTACTTCCTATTCTGCCCACCCTTTACTTAAGCAGTAAAGTACCTCTTTTCTAAAGAACCAGGAAACAT
CAAAATAACCACAACAAAAATCTAAACAGTTTTCAAATAATACATTCAGTTCTCATAATAATAAGGGCTATATACCATGGGTCCACACAA
ACTGTGCTGCAAACATATAATCTATTAGTTTAGTAAAATTTCCAGAGATGTGAATTTAATATTTTCTTGATAAAATCATAAAAAAGCATC
ACCATTATTAAAGATGCATTTGTTCATTTCAATAAACAGAAATTAATGAAACAAATTACTTTTGTACAAAATAAATGATGATTATGTGGC
ACTTTATTGAATTTTATAGAAATATTCCAATCTAAGTGATAAAGTAACAACTGAGAAACTTCAGAATGAAAGCCTTATTGATTCAAAAGG
AAAATTACCATATGCTTTAGGGCTGATGAACTTGCCACAATTGCTTAGACATAACAAAGATATTTTCTACATTGTTTTCCAACTTTATAT
GCTGAAAGATAATTAGGAGGTCCGGGTGGAGTGTATCTAAATGACTAGAACTTTAAGTTGCAATATAGATTTTCTCTTTTTAACAAAGGA
AGAATATAAATTAATTTGGATCAAATTTATTTGCCTTCTTTGCAATCTTGGTGATCATTTTGGAAAGTAAATTGAAAGGAAAGTTAAATA
GCCACATAGTTTTCTTTTGCATCTCAATTTGGTTGAGAATTTCTAAGGAAGGTTAATATGACTTTAGAATGAATAAAGAGACTGTCAAAC
AACAAGTACTCTCCCTAAAAAAGAGGAAAGAATGCCTTCCTAAAATATTTGTTTCCTATTGTATATGTCACCAATTGGAAAATGCCAATC
TCATCTGCAAGTGTGAGAAATGGAACAAGGAGAGGAGCCAACTCTAGTAAAATGTAGTGAGGCCATAATCCAAGGCAAAGTTTAACAAAT
CTTGATTGTGTAATTTCTTATTCTGTTGATTCATTTTGTCACCCACCAGACTACCAAAAATAAAGCACAGACATGACAATTTTAGTATAT
ACAACAGATTTGGCAAATAATACATAATCTTATTGTAATTGCCAGTAGCAATATCTTAAGGGGCATGAGTCTTTCACAGTATTGGACTTT
GAAAAATTGGTACAGGGAGTAATTTTCAACAGACTGATACTTGAAGTCACTCAATTACTACTTTGACCTATCATAATTTGTTTCTAATCT
TGTCATTTGCTCATATATACTATTAATATAACCAGTTGCTCTTTTCATAATGTACTATTTCTATGTAAAGATGTAAAGATTTTGATTTTC
CTATGTTTTAAAATTGTAATGTGCATGATCTTTTATTTCTTGTGTTTCAATTACCAAGTCAGTATTCTAAGGTTGTAAGATTACTGTAAA
AATTATATTCCAATATTTTATCTAAACTTAAGTGTGGCCAGCATTATTGGTTTCAGAGTTGCCTAAACAACACAGAATATCCTTAATTCA
GTTTGTAAAAGAGTTTTGACCAGTGTAAAAAAGTGAAGACACAGTTTCATGTTTCAAGTTTAAAATGGAAAGTTAATATCATTTGAGCAC
TTATGTGTTTTCATGTCTTCTACTTAATCTGTATGTGAAAGTAAAATATTTTTAACACCATTATTTATGCCATGTAAAGTGGGTTCTCAG
AAGCACAAGCACAGATATTTACCTTCTGAAGACATTTTTGGCTATAAAAGTGCATTGGATGGCAAACACTATTTGAGTCAGGTGTTAGAA
ATTTATTAGATGTATTATATTACATAGTAGAATAAGGTCCCTTTCTCATTTTGTTTTTCCTAAAAATAAGAAAAAAAAGAAGTGTGATAG
TAAACTGTCTTTGCTAATGTCCTGCCAGATGTTTAACTTCAAATTAAGCAAAAAGTAGGTACAATATGATGATGATCCTGATGATGATGA
TGATGATGATGATGAAGAATAAATGGAATCAAAATGCTAGCTTTATTTGACATTAATAAGTAAAATAAGTCATCATTTTTTCAACTCTGT
AGCACAGCTGTTTACATTGAATAATTTTCTCTATTGTGCTGTTAATTATATAGTAATGTATCAAAATAGAAATAGGAACTTTCTTTTCAT
TTCTTATTCATTTATGAAGAAATCTTTTCACACATAAATGATTGAATGTTCTTGTTCAGAATGACCACATAATCATTGCTTAGAAGAAGA
TACCAATTCTTTTAAAAGAAAAAAAGTCTGTTTATAATAATCAGAATCAAATGTTGTTTGTTTCTTCTAAACGTTAATGGAGAAAATTGA
AGGTGGTAAAATGTCATGTTTATTCAGGCTGGGAACTGTATTCACAGTAGAAGTTTCAGTGGTCAACATATCTATGACTCTTTAGGCTGC
TGTAGTTTTACAGTCAATTATTTAAAAGTGAGTAGTTACATTTATAAGAGCCTGAGAATACTTAGACTCAGTCATTTGTTAGTATTTTTA
CCAAAATCTCTTAGTTTCAGACATGTCAGAAGCAGCTATATAGCATATCTTATTCTATGATATACATCAGGCTATCTCAAGTTCCTGTCT
CACAGTTAATTCAAAGAAGGATTAGGATTTCTGTATTTTTTCTCATTTGAATCTTTATGTGCATTTGGTTTGTGTACATGCTTTTTGTAG

>35729_35729_1_HCFC1-EPHA5_HCFC1_chrX_153236099_ENST00000310441_EPHA5_chr4_66189937_ENST00000273854_length(amino acids)=202AA_BP=
MQKHRWQVGGRHGRSHSSGKGCGGEKSTSGKGAPQFLSHTPFRLRQLSRRSGFSHSGRRLHGGRHLNCPPSLWLFPFFSLTPSPQEPPET
VERLGSRSWRPLSPVAPTTCPGAPAYKLGREALGAAILSRLSLLPSSVVALPRRKWRSPGPVPTPPSPQHWPASGAGGKEPQAPRSSQPR

--------------------------------------------------------------
>35729_35729_2_HCFC1-EPHA5_HCFC1_chrX_153236099_ENST00000310441_EPHA5_chr4_66189937_ENST00000354839_length(transcript)=1452nt_BP=1160nt
CGGCTCCCAGGGAGGAGGCATGAGCGCCCTGCCGTTACCGCTTCTTCTGCCGTACAGTTGCCGCTTCGGGGCCTAACTCTAGCTCTTTGA
AGCGGCTCCTGTGGGAAGGAGTCATAAGGCGGGAAGTGAGGATCGGACACCGCCTTGAGTTTGGTGTGCAGTGGAAGAACTGACCTAGGA
GGAAGAGAATAGGGGGGAACGGGGAGCTAGTCTCAAGATGGCGGCTCCCACGGCGGCAGGCGCAGCCTGAGCAGCAGAGGCGGACTAAGG
GGAGAGGCGCGAGACTTCACAAGCCGTACGGCGCGAGCCCCCAAACGGCCCTCGAGAGCTCGAGCTGGTTCCACCGGCCTCCGGCCCGCC
TCCATTCGTTAGGTGTGTCGAGGCTGTTTCGGGAGCGGCGGCTGCACTAAGGCGCTGGGCGGGGAAGCGGGACGGTCTCAAGATGGCGGC
TCCCACAATTGTGGTCTGAGCGCCGGCGGGGCTGCGACGACCGCGGCGCTTGTGGCTCCTTTCCACCCGCCCCGGAAGCCGGCCAGTGCT
GGGGACTTGGGGGTGTGGGAACCGGGCCGGGGCTCCGCCATTTCCGGCGGGGGAGGGCTACGACTGAGGAAGGGAGGAGAGAGAGGCGGC
TCAAGATGGCGGCTCCCAGGGCCTCCCGCCCGAGCTTGTAAGCGGGAGCGCCCGGACAAGTAGTCGGGGCGACGGGACTCAGCGGCCTCC
AGCTTCTTGAGCCTAGGCGCTCGACAGTTTCGGGCGGCTCTTGCGGAGACGGGGTGAGCGAGAAGAAAGGGAAGAGCCAAAGGGAAGGAG
GGCAGTTAAGATGGCGGCCTCCATGGAGTCGTCTACCGCTGTGTGAGAAACCGCTTCTCCGTGAGAGCTGCCTTAGACGAAAGGGGGTGT
GTGAAAGGAATTGAGGGGCTCCCTTCCCGCTTGTTGACTTCTCCCCACCGCACCCTTTCCCGGAACTATGGCTTCGGCCGTGTCGCCCGC
CAACTTGCCAGCGGTGCTTCTGCAGCCCCGCTGGAAGCGAGTGGTGGGCTGGTCGGGTCCGGTGCCACGGCCCCGCCACGGCCACCGCGC
CGTGGCCATCAAGGAGCTCATCGTGGTGTTTGGCGGCGGCAACGAGGGAATAGTGGACGAACTGCACGTGTACAACACGGGGATTTGAGA
CGGCTTGGAGTGACTCTTGTCGGTCACCAGAAGAAGATCATGAACAGCCTTCAAGAAATGAAGGTGCAGCTGGTAAACGGAATGGTGCCA
TTGTAACTTCATGTAAATGTCGCTTCTTCAAGTGAATGATTCTGCACTTTGTAAACAGCACTGAGATTTATTTTAACAAAAAAAGGGGGA
AAAGGGAAAACAGTGATTTCTAAACCTTAGAAAACATTTGCCTCAGCCACAGAATTTGTAATCATGGTTTTACTGAAGTATCCAGTTCTT

>35729_35729_2_HCFC1-EPHA5_HCFC1_chrX_153236099_ENST00000310441_EPHA5_chr4_66189937_ENST00000354839_length(amino acids)=202AA_BP=
MQKHRWQVGGRHGRSHSSGKGCGGEKSTSGKGAPQFLSHTPFRLRQLSRRSGFSHSGRRLHGGRHLNCPPSLWLFPFFSLTPSPQEPPET
VERLGSRSWRPLSPVAPTTCPGAPAYKLGREALGAAILSRLSLLPSSVVALPRRKWRSPGPVPTPPSPQHWPASGAGGKEPQAPRSSQPR

--------------------------------------------------------------
>35729_35729_3_HCFC1-EPHA5_HCFC1_chrX_153236099_ENST00000354233_EPHA5_chr4_66189937_ENST00000273854_length(transcript)=5378nt_BP=721nt
AAGATGGCGGCTCCCACAATTGTGGTCTGAGCGCCGGCGGGGCTGCGACGACCGCGGCGCTTGTGGCTCCTTTCCACCCGCCCCGGAAGC
CGGCCAGTGCTGGGGACTTGGGGGTGTGGGAACCGGGCCGGGGCTCCGCCATTTCCGGCGGGGGAGGGCTACGACTGAGGAAGGGAGGAG
AGAGAGGCGGCTCAAGATGGCGGCTCCCAGGGCCTCCCGCCCGAGCTTGTAAGCGGGAGCGCCCGGACAAGTAGTCGGGGCGACGGGACT
CAGCGGCCTCCAGCTTCTTGAGCCTAGGCGCTCGACAGTTTCGGGCGGCTCTTGCGGAGACGGGGTGAGCGAGAAGAAAGGGAAGAGCCA
AAGGGAAGGAGGGCAGTTAAGATGGCGGCCTCCATGGAGTCGTCTACCGCTGTGTGAGAAACCGCTTCTCCGTGAGAGCTGCCTTAGACG
AAAGGGGGTGTGTGAAAGGAATTGAGGGGCTCCCTTCCCGCTTGTTGACTTCTCCCCACCGCACCCTTTCCCGGAACTATGGCTTCGGCC
GTGTCGCCCGCCAACTTGCCAGCGGTGCTTCTGCAGCCCCGCTGGAAGCGAGTGGTGGGCTGGTCGGGTCCGGTGCCACGGCCCCGCCAC
GGCCACCGCGCCGTGGCCATCAAGGAGCTCATCGTGGTGTTTGGCGGCGGCAACGAGGGAATAGTGGACGAACTGCACGTGTACAACACG
GGGATTTGAGACGGCTTGGAGTGACTCTTGTCGGTCACCAGAAGAAGATCATGAACAGCCTTCAAGAAATGAAGGTGCAGCTGGTAAACG
GAATGGTGCCATTGTAACTTCATGTAAATGTCGCTTCTTCAAGTGAATGATTCTGCACTTTGTAAACAGCACTGAGATTTATTTTAACAA
AAAAAGGGGGAAAAGGGAAAACAGTGATTTCTAAACCTTAGAAAACATTTGCCTCAGCCACAGAATTTGTAATCATGGTTTTACTGAAGT
ATCCAGTTCTTAGTCCTTAGTCTTCATTTTTCATGAAGCAAACATATCTTGCATTAAAAGGGACATGAAGTTAGACATCATCTTAAGTTA
CAACAACAGAATCCTTCCCACTACTTCTACAAAATTTTGTACATGAAATATATAATTATATAGCACTTTTATAGACTGAATTAAGGCAAC
CCCTTTCAAAACTTCCAGGGATCTACTTGAAAGGAAATGTTTTATAGCCATTTGTGAGCTAACAAAAGCTACAGTTTACTGAAGTTTACT
TCAAGTCTTAATTGTCTACAAAAGTGTATTGAAGAGCAATATGATTAGATTATTTCTTAATAGATATCTTCTTTTGTAATTTTAAAATGC
TGTTACACAGCGTTAAGTTATAGAAACTAGTGTGTAAACATGTTGCTTGATCAAGAAAAAGTACAATACAGGGTGTATATTTATTTTTTG
TGTTATAAAGTTTACTTTTAGTTGCTCTTCTAGAGATTATTAGGTAATAAATGTGTATATACTGTATAATTTGCAATATACCCAGGAACT
GATTTAAGATGGAATTGTGTGTGTGTTTGCTTGCACATGTGTGTGTTACCATTCTGCTTGCATTTCTAATAGTGTTTCAATTTTAGCAAC
ATATAGGAGCAAGTGTTCCAGAATGTAATATGAATAGGAGAAATAGGGAAGCAGTAAAACAAAATTTAACACAAGCTTGTGTCTCTTTTC
CTCTCATGTGTCCAAAAGCTAATCTCTTTATTCACTAAAAGGAAATGTGTATAAGACTAAATCCCCTTTGGCTTTTTAAAAACATTTTGT
GATATCAGTGACAATGCAGTTCTTCTAGCCATTAATCTTGTACCCCTGTAAGAAATTTCACCTTTCTGAGTCCTGAAAAGTATCTTGTCA
AGCAAAGTTGACACCGAAGGGCACATTTTCAGCAGGATGTAGAAGGATTTAACTGTGCAGGCTTCTGTTAATGTTGTTAAATCCAGGCAC
ATAGCACGAAGCATCACCCTTAAGTGTTAATCCGTTGTAACCATTCCCATTTTGACTCAGTTCTAGAAATTTTGACTCTAAGGCAGCAAT
GGAATTATGACAAATATATATATATACACATACACACACACAAATATATATATATGCTTATTTCCCTTCAGAATTTTATTTCAATAATTG
ATAAGTTTTATTTTTAATGGATGTTTATTCATTTGTTAATTTCAGTTTGTATTCAGTTACATGGCTTTGAGTTTATTTTATTGAACCAAT
CCAAGGTATTATGTAATTAGGCTTATTAAGGAATATAACATATCTTCTATGTATGCTCTATATACCACACATGATGAAGACTTATATTTG
TGATACAAATTATGCAGTGTATTAGAAATTGTCCAAAACTGAGCTCCTGAGATAACCAACATTTTTGTATTATTACACTTTATAAAAATT
ATGGAATGTCATGTGATTAGTCAAAATCAGAGCATTTAAATAAAATACAGCCTACTCATGATTATCAATGTTAATAGTACAGTAGATCAG
AGAAGCCTGGATTAATGAAATTTATCAGAAATATAGCCACGTTATATTAATGGTATTCTTTTTTCCAAGCACTTGTTTTATTTGAATATT
AGCACATATAAGAATAAACTTTTGGGAAATAACTACTTCCTATTCTGCCCACCCTTTACTTAAGCAGTAAAGTACCTCTTTTCTAAAGAA
CCAGGAAACATCAAAATAACCACAACAAAAATCTAAACAGTTTTCAAATAATACATTCAGTTCTCATAATAATAAGGGCTATATACCATG
GGTCCACACAAACTGTGCTGCAAACATATAATCTATTAGTTTAGTAAAATTTCCAGAGATGTGAATTTAATATTTTCTTGATAAAATCAT
AAAAAAGCATCACCATTATTAAAGATGCATTTGTTCATTTCAATAAACAGAAATTAATGAAACAAATTACTTTTGTACAAAATAAATGAT
GATTATGTGGCACTTTATTGAATTTTATAGAAATATTCCAATCTAAGTGATAAAGTAACAACTGAGAAACTTCAGAATGAAAGCCTTATT
GATTCAAAAGGAAAATTACCATATGCTTTAGGGCTGATGAACTTGCCACAATTGCTTAGACATAACAAAGATATTTTCTACATTGTTTTC
CAACTTTATATGCTGAAAGATAATTAGGAGGTCCGGGTGGAGTGTATCTAAATGACTAGAACTTTAAGTTGCAATATAGATTTTCTCTTT
TTAACAAAGGAAGAATATAAATTAATTTGGATCAAATTTATTTGCCTTCTTTGCAATCTTGGTGATCATTTTGGAAAGTAAATTGAAAGG
AAAGTTAAATAGCCACATAGTTTTCTTTTGCATCTCAATTTGGTTGAGAATTTCTAAGGAAGGTTAATATGACTTTAGAATGAATAAAGA
GACTGTCAAACAACAAGTACTCTCCCTAAAAAAGAGGAAAGAATGCCTTCCTAAAATATTTGTTTCCTATTGTATATGTCACCAATTGGA
AAATGCCAATCTCATCTGCAAGTGTGAGAAATGGAACAAGGAGAGGAGCCAACTCTAGTAAAATGTAGTGAGGCCATAATCCAAGGCAAA
GTTTAACAAATCTTGATTGTGTAATTTCTTATTCTGTTGATTCATTTTGTCACCCACCAGACTACCAAAAATAAAGCACAGACATGACAA
TTTTAGTATATACAACAGATTTGGCAAATAATACATAATCTTATTGTAATTGCCAGTAGCAATATCTTAAGGGGCATGAGTCTTTCACAG
TATTGGACTTTGAAAAATTGGTACAGGGAGTAATTTTCAACAGACTGATACTTGAAGTCACTCAATTACTACTTTGACCTATCATAATTT
GTTTCTAATCTTGTCATTTGCTCATATATACTATTAATATAACCAGTTGCTCTTTTCATAATGTACTATTTCTATGTAAAGATGTAAAGA
TTTTGATTTTCCTATGTTTTAAAATTGTAATGTGCATGATCTTTTATTTCTTGTGTTTCAATTACCAAGTCAGTATTCTAAGGTTGTAAG
ATTACTGTAAAAATTATATTCCAATATTTTATCTAAACTTAAGTGTGGCCAGCATTATTGGTTTCAGAGTTGCCTAAACAACACAGAATA
TCCTTAATTCAGTTTGTAAAAGAGTTTTGACCAGTGTAAAAAAGTGAAGACACAGTTTCATGTTTCAAGTTTAAAATGGAAAGTTAATAT
CATTTGAGCACTTATGTGTTTTCATGTCTTCTACTTAATCTGTATGTGAAAGTAAAATATTTTTAACACCATTATTTATGCCATGTAAAG
TGGGTTCTCAGAAGCACAAGCACAGATATTTACCTTCTGAAGACATTTTTGGCTATAAAAGTGCATTGGATGGCAAACACTATTTGAGTC
AGGTGTTAGAAATTTATTAGATGTATTATATTACATAGTAGAATAAGGTCCCTTTCTCATTTTGTTTTTCCTAAAAATAAGAAAAAAAAG
AAGTGTGATAGTAAACTGTCTTTGCTAATGTCCTGCCAGATGTTTAACTTCAAATTAAGCAAAAAGTAGGTACAATATGATGATGATCCT
GATGATGATGATGATGATGATGATGAAGAATAAATGGAATCAAAATGCTAGCTTTATTTGACATTAATAAGTAAAATAAGTCATCATTTT
TTCAACTCTGTAGCACAGCTGTTTACATTGAATAATTTTCTCTATTGTGCTGTTAATTATATAGTAATGTATCAAAATAGAAATAGGAAC
TTTCTTTTCATTTCTTATTCATTTATGAAGAAATCTTTTCACACATAAATGATTGAATGTTCTTGTTCAGAATGACCACATAATCATTGC
TTAGAAGAAGATACCAATTCTTTTAAAAGAAAAAAAGTCTGTTTATAATAATCAGAATCAAATGTTGTTTGTTTCTTCTAAACGTTAATG
GAGAAAATTGAAGGTGGTAAAATGTCATGTTTATTCAGGCTGGGAACTGTATTCACAGTAGAAGTTTCAGTGGTCAACATATCTATGACT
CTTTAGGCTGCTGTAGTTTTACAGTCAATTATTTAAAAGTGAGTAGTTACATTTATAAGAGCCTGAGAATACTTAGACTCAGTCATTTGT
TAGTATTTTTACCAAAATCTCTTAGTTTCAGACATGTCAGAAGCAGCTATATAGCATATCTTATTCTATGATATACATCAGGCTATCTCA
AGTTCCTGTCTCACAGTTAATTCAAAGAAGGATTAGGATTTCTGTATTTTTTCTCATTTGAATCTTTATGTGCATTTGGTTTGTGTACAT

>35729_35729_3_HCFC1-EPHA5_HCFC1_chrX_153236099_ENST00000354233_EPHA5_chr4_66189937_ENST00000273854_length(amino acids)=129AA_BP=0
MKLQWHHSVYQLHLHFLKAVHDLLLVTDKSHSKPSQIPVLYTCSSSTIPSLPPPNTTMSSLMATARWPWRGRGTGPDQPTTRFQRGCRST

--------------------------------------------------------------
>35729_35729_4_HCFC1-EPHA5_HCFC1_chrX_153236099_ENST00000354233_EPHA5_chr4_66189937_ENST00000354839_length(transcript)=1013nt_BP=721nt
AAGATGGCGGCTCCCACAATTGTGGTCTGAGCGCCGGCGGGGCTGCGACGACCGCGGCGCTTGTGGCTCCTTTCCACCCGCCCCGGAAGC
CGGCCAGTGCTGGGGACTTGGGGGTGTGGGAACCGGGCCGGGGCTCCGCCATTTCCGGCGGGGGAGGGCTACGACTGAGGAAGGGAGGAG
AGAGAGGCGGCTCAAGATGGCGGCTCCCAGGGCCTCCCGCCCGAGCTTGTAAGCGGGAGCGCCCGGACAAGTAGTCGGGGCGACGGGACT
CAGCGGCCTCCAGCTTCTTGAGCCTAGGCGCTCGACAGTTTCGGGCGGCTCTTGCGGAGACGGGGTGAGCGAGAAGAAAGGGAAGAGCCA
AAGGGAAGGAGGGCAGTTAAGATGGCGGCCTCCATGGAGTCGTCTACCGCTGTGTGAGAAACCGCTTCTCCGTGAGAGCTGCCTTAGACG
AAAGGGGGTGTGTGAAAGGAATTGAGGGGCTCCCTTCCCGCTTGTTGACTTCTCCCCACCGCACCCTTTCCCGGAACTATGGCTTCGGCC
GTGTCGCCCGCCAACTTGCCAGCGGTGCTTCTGCAGCCCCGCTGGAAGCGAGTGGTGGGCTGGTCGGGTCCGGTGCCACGGCCCCGCCAC
GGCCACCGCGCCGTGGCCATCAAGGAGCTCATCGTGGTGTTTGGCGGCGGCAACGAGGGAATAGTGGACGAACTGCACGTGTACAACACG
GGGATTTGAGACGGCTTGGAGTGACTCTTGTCGGTCACCAGAAGAAGATCATGAACAGCCTTCAAGAAATGAAGGTGCAGCTGGTAAACG
GAATGGTGCCATTGTAACTTCATGTAAATGTCGCTTCTTCAAGTGAATGATTCTGCACTTTGTAAACAGCACTGAGATTTATTTTAACAA
AAAAAGGGGGAAAAGGGAAAACAGTGATTTCTAAACCTTAGAAAACATTTGCCTCAGCCACAGAATTTGTAATCATGGTTTTACTGAAGT

>35729_35729_4_HCFC1-EPHA5_HCFC1_chrX_153236099_ENST00000354233_EPHA5_chr4_66189937_ENST00000354839_length(amino acids)=129AA_BP=0
MKLQWHHSVYQLHLHFLKAVHDLLLVTDKSHSKPSQIPVLYTCSSSTIPSLPPPNTTMSSLMATARWPWRGRGTGPDQPTTRFQRGCRST

--------------------------------------------------------------
>35729_35729_5_HCFC1-EPHA5_HCFC1_chrX_153236099_ENST00000369984_EPHA5_chr4_66189937_ENST00000273854_length(transcript)=5194nt_BP=537nt
AGGCGGCTCAAGATGGCGGCTCCCAGGGCCTCCCGCCCGAGCTTGTAAGCGGGAGCGCCCGGACAAGTAGTCGGGGCGACGGGACTCAGC
GGCCTCCAGCTTCTTGAGCCTAGGCGCTCGACAGTTTCGGGCGGCTCTTGCGGAGACGGGGTGAGCGAGAAGAAAGGGAAGAGCCAAAGG
GAAGGAGGGCAGTTAAGATGGCGGCCTCCATGGAGTCGTCTACCGCTGTGTGAGAAACCGCTTCTCCGTGAGAGCTGCCTTAGACGAAAG
GGGGTGTGTGAAAGGAATTGAGGGGCTCCCTTCCCGCTTGTTGACTTCTCCCCACCGCACCCTTTCCCGGAACTATGGCTTCGGCCGTGT
CGCCCGCCAACTTGCCAGCGGTGCTTCTGCAGCCCCGCTGGAAGCGAGTGGTGGGCTGGTCGGGTCCGGTGCCACGGCCCCGCCACGGCC
ACCGCGCCGTGGCCATCAAGGAGCTCATCGTGGTGTTTGGCGGCGGCAACGAGGGAATAGTGGACGAACTGCACGTGTACAACACGGGGA
TTTGAGACGGCTTGGAGTGACTCTTGTCGGTCACCAGAAGAAGATCATGAACAGCCTTCAAGAAATGAAGGTGCAGCTGGTAAACGGAAT
GGTGCCATTGTAACTTCATGTAAATGTCGCTTCTTCAAGTGAATGATTCTGCACTTTGTAAACAGCACTGAGATTTATTTTAACAAAAAA
AGGGGGAAAAGGGAAAACAGTGATTTCTAAACCTTAGAAAACATTTGCCTCAGCCACAGAATTTGTAATCATGGTTTTACTGAAGTATCC
AGTTCTTAGTCCTTAGTCTTCATTTTTCATGAAGCAAACATATCTTGCATTAAAAGGGACATGAAGTTAGACATCATCTTAAGTTACAAC
AACAGAATCCTTCCCACTACTTCTACAAAATTTTGTACATGAAATATATAATTATATAGCACTTTTATAGACTGAATTAAGGCAACCCCT
TTCAAAACTTCCAGGGATCTACTTGAAAGGAAATGTTTTATAGCCATTTGTGAGCTAACAAAAGCTACAGTTTACTGAAGTTTACTTCAA
GTCTTAATTGTCTACAAAAGTGTATTGAAGAGCAATATGATTAGATTATTTCTTAATAGATATCTTCTTTTGTAATTTTAAAATGCTGTT
ACACAGCGTTAAGTTATAGAAACTAGTGTGTAAACATGTTGCTTGATCAAGAAAAAGTACAATACAGGGTGTATATTTATTTTTTGTGTT
ATAAAGTTTACTTTTAGTTGCTCTTCTAGAGATTATTAGGTAATAAATGTGTATATACTGTATAATTTGCAATATACCCAGGAACTGATT
TAAGATGGAATTGTGTGTGTGTTTGCTTGCACATGTGTGTGTTACCATTCTGCTTGCATTTCTAATAGTGTTTCAATTTTAGCAACATAT
AGGAGCAAGTGTTCCAGAATGTAATATGAATAGGAGAAATAGGGAAGCAGTAAAACAAAATTTAACACAAGCTTGTGTCTCTTTTCCTCT
CATGTGTCCAAAAGCTAATCTCTTTATTCACTAAAAGGAAATGTGTATAAGACTAAATCCCCTTTGGCTTTTTAAAAACATTTTGTGATA
TCAGTGACAATGCAGTTCTTCTAGCCATTAATCTTGTACCCCTGTAAGAAATTTCACCTTTCTGAGTCCTGAAAAGTATCTTGTCAAGCA
AAGTTGACACCGAAGGGCACATTTTCAGCAGGATGTAGAAGGATTTAACTGTGCAGGCTTCTGTTAATGTTGTTAAATCCAGGCACATAG
CACGAAGCATCACCCTTAAGTGTTAATCCGTTGTAACCATTCCCATTTTGACTCAGTTCTAGAAATTTTGACTCTAAGGCAGCAATGGAA
TTATGACAAATATATATATATACACATACACACACACAAATATATATATATGCTTATTTCCCTTCAGAATTTTATTTCAATAATTGATAA
GTTTTATTTTTAATGGATGTTTATTCATTTGTTAATTTCAGTTTGTATTCAGTTACATGGCTTTGAGTTTATTTTATTGAACCAATCCAA
GGTATTATGTAATTAGGCTTATTAAGGAATATAACATATCTTCTATGTATGCTCTATATACCACACATGATGAAGACTTATATTTGTGAT
ACAAATTATGCAGTGTATTAGAAATTGTCCAAAACTGAGCTCCTGAGATAACCAACATTTTTGTATTATTACACTTTATAAAAATTATGG
AATGTCATGTGATTAGTCAAAATCAGAGCATTTAAATAAAATACAGCCTACTCATGATTATCAATGTTAATAGTACAGTAGATCAGAGAA
GCCTGGATTAATGAAATTTATCAGAAATATAGCCACGTTATATTAATGGTATTCTTTTTTCCAAGCACTTGTTTTATTTGAATATTAGCA
CATATAAGAATAAACTTTTGGGAAATAACTACTTCCTATTCTGCCCACCCTTTACTTAAGCAGTAAAGTACCTCTTTTCTAAAGAACCAG
GAAACATCAAAATAACCACAACAAAAATCTAAACAGTTTTCAAATAATACATTCAGTTCTCATAATAATAAGGGCTATATACCATGGGTC
CACACAAACTGTGCTGCAAACATATAATCTATTAGTTTAGTAAAATTTCCAGAGATGTGAATTTAATATTTTCTTGATAAAATCATAAAA
AAGCATCACCATTATTAAAGATGCATTTGTTCATTTCAATAAACAGAAATTAATGAAACAAATTACTTTTGTACAAAATAAATGATGATT
ATGTGGCACTTTATTGAATTTTATAGAAATATTCCAATCTAAGTGATAAAGTAACAACTGAGAAACTTCAGAATGAAAGCCTTATTGATT
CAAAAGGAAAATTACCATATGCTTTAGGGCTGATGAACTTGCCACAATTGCTTAGACATAACAAAGATATTTTCTACATTGTTTTCCAAC
TTTATATGCTGAAAGATAATTAGGAGGTCCGGGTGGAGTGTATCTAAATGACTAGAACTTTAAGTTGCAATATAGATTTTCTCTTTTTAA
CAAAGGAAGAATATAAATTAATTTGGATCAAATTTATTTGCCTTCTTTGCAATCTTGGTGATCATTTTGGAAAGTAAATTGAAAGGAAAG
TTAAATAGCCACATAGTTTTCTTTTGCATCTCAATTTGGTTGAGAATTTCTAAGGAAGGTTAATATGACTTTAGAATGAATAAAGAGACT
GTCAAACAACAAGTACTCTCCCTAAAAAAGAGGAAAGAATGCCTTCCTAAAATATTTGTTTCCTATTGTATATGTCACCAATTGGAAAAT
GCCAATCTCATCTGCAAGTGTGAGAAATGGAACAAGGAGAGGAGCCAACTCTAGTAAAATGTAGTGAGGCCATAATCCAAGGCAAAGTTT
AACAAATCTTGATTGTGTAATTTCTTATTCTGTTGATTCATTTTGTCACCCACCAGACTACCAAAAATAAAGCACAGACATGACAATTTT
AGTATATACAACAGATTTGGCAAATAATACATAATCTTATTGTAATTGCCAGTAGCAATATCTTAAGGGGCATGAGTCTTTCACAGTATT
GGACTTTGAAAAATTGGTACAGGGAGTAATTTTCAACAGACTGATACTTGAAGTCACTCAATTACTACTTTGACCTATCATAATTTGTTT
CTAATCTTGTCATTTGCTCATATATACTATTAATATAACCAGTTGCTCTTTTCATAATGTACTATTTCTATGTAAAGATGTAAAGATTTT
GATTTTCCTATGTTTTAAAATTGTAATGTGCATGATCTTTTATTTCTTGTGTTTCAATTACCAAGTCAGTATTCTAAGGTTGTAAGATTA
CTGTAAAAATTATATTCCAATATTTTATCTAAACTTAAGTGTGGCCAGCATTATTGGTTTCAGAGTTGCCTAAACAACACAGAATATCCT
TAATTCAGTTTGTAAAAGAGTTTTGACCAGTGTAAAAAAGTGAAGACACAGTTTCATGTTTCAAGTTTAAAATGGAAAGTTAATATCATT
TGAGCACTTATGTGTTTTCATGTCTTCTACTTAATCTGTATGTGAAAGTAAAATATTTTTAACACCATTATTTATGCCATGTAAAGTGGG
TTCTCAGAAGCACAAGCACAGATATTTACCTTCTGAAGACATTTTTGGCTATAAAAGTGCATTGGATGGCAAACACTATTTGAGTCAGGT
GTTAGAAATTTATTAGATGTATTATATTACATAGTAGAATAAGGTCCCTTTCTCATTTTGTTTTTCCTAAAAATAAGAAAAAAAAGAAGT
GTGATAGTAAACTGTCTTTGCTAATGTCCTGCCAGATGTTTAACTTCAAATTAAGCAAAAAGTAGGTACAATATGATGATGATCCTGATG
ATGATGATGATGATGATGATGAAGAATAAATGGAATCAAAATGCTAGCTTTATTTGACATTAATAAGTAAAATAAGTCATCATTTTTTCA
ACTCTGTAGCACAGCTGTTTACATTGAATAATTTTCTCTATTGTGCTGTTAATTATATAGTAATGTATCAAAATAGAAATAGGAACTTTC
TTTTCATTTCTTATTCATTTATGAAGAAATCTTTTCACACATAAATGATTGAATGTTCTTGTTCAGAATGACCACATAATCATTGCTTAG
AAGAAGATACCAATTCTTTTAAAAGAAAAAAAGTCTGTTTATAATAATCAGAATCAAATGTTGTTTGTTTCTTCTAAACGTTAATGGAGA
AAATTGAAGGTGGTAAAATGTCATGTTTATTCAGGCTGGGAACTGTATTCACAGTAGAAGTTTCAGTGGTCAACATATCTATGACTCTTT
AGGCTGCTGTAGTTTTACAGTCAATTATTTAAAAGTGAGTAGTTACATTTATAAGAGCCTGAGAATACTTAGACTCAGTCATTTGTTAGT
ATTTTTACCAAAATCTCTTAGTTTCAGACATGTCAGAAGCAGCTATATAGCATATCTTATTCTATGATATACATCAGGCTATCTCAAGTT
CCTGTCTCACAGTTAATTCAAAGAAGGATTAGGATTTCTGTATTTTTTCTCATTTGAATCTTTATGTGCATTTGGTTTGTGTACATGCTT

>35729_35729_5_HCFC1-EPHA5_HCFC1_chrX_153236099_ENST00000369984_EPHA5_chr4_66189937_ENST00000273854_length(amino acids)=129AA_BP=0
MKLQWHHSVYQLHLHFLKAVHDLLLVTDKSHSKPSQIPVLYTCSSSTIPSLPPPNTTMSSLMATARWPWRGRGTGPDQPTTRFQRGCRST

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>35729_35729_6_HCFC1-EPHA5_HCFC1_chrX_153236099_ENST00000369984_EPHA5_chr4_66189937_ENST00000354839_length(transcript)=829nt_BP=537nt
AGGCGGCTCAAGATGGCGGCTCCCAGGGCCTCCCGCCCGAGCTTGTAAGCGGGAGCGCCCGGACAAGTAGTCGGGGCGACGGGACTCAGC
GGCCTCCAGCTTCTTGAGCCTAGGCGCTCGACAGTTTCGGGCGGCTCTTGCGGAGACGGGGTGAGCGAGAAGAAAGGGAAGAGCCAAAGG
GAAGGAGGGCAGTTAAGATGGCGGCCTCCATGGAGTCGTCTACCGCTGTGTGAGAAACCGCTTCTCCGTGAGAGCTGCCTTAGACGAAAG
GGGGTGTGTGAAAGGAATTGAGGGGCTCCCTTCCCGCTTGTTGACTTCTCCCCACCGCACCCTTTCCCGGAACTATGGCTTCGGCCGTGT
CGCCCGCCAACTTGCCAGCGGTGCTTCTGCAGCCCCGCTGGAAGCGAGTGGTGGGCTGGTCGGGTCCGGTGCCACGGCCCCGCCACGGCC
ACCGCGCCGTGGCCATCAAGGAGCTCATCGTGGTGTTTGGCGGCGGCAACGAGGGAATAGTGGACGAACTGCACGTGTACAACACGGGGA
TTTGAGACGGCTTGGAGTGACTCTTGTCGGTCACCAGAAGAAGATCATGAACAGCCTTCAAGAAATGAAGGTGCAGCTGGTAAACGGAAT
GGTGCCATTGTAACTTCATGTAAATGTCGCTTCTTCAAGTGAATGATTCTGCACTTTGTAAACAGCACTGAGATTTATTTTAACAAAAAA
AGGGGGAAAAGGGAAAACAGTGATTTCTAAACCTTAGAAAACATTTGCCTCAGCCACAGAATTTGTAATCATGGTTTTACTGAAGTATCC

>35729_35729_6_HCFC1-EPHA5_HCFC1_chrX_153236099_ENST00000369984_EPHA5_chr4_66189937_ENST00000354839_length(amino acids)=129AA_BP=0
MKLQWHHSVYQLHLHFLKAVHDLLLVTDKSHSKPSQIPVLYTCSSSTIPSLPPPNTTMSSLMATARWPWRGRGTGPDQPTTRFQRGCRST

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Fusion Gene PPI Analysis for HCFC1-EPHA5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-126813_91264.333333333333332036.0GABP2
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-127813_91264.333333333333331967.0GABP2
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-126610_72264.333333333333332036.0SIN3A
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-127610_72264.333333333333331967.0SIN3A
HgeneHCFC1chrX:153236099chr4:66189937ENST00000310441-126750_90264.333333333333332036.0ZBTB17
HgeneHCFC1chrX:153236099chr4:66189937ENST00000354233-127750_90264.333333333333331967.0ZBTB17


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HCFC1-EPHA5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HCFC1-EPHA5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHCFC1C0796208MENTAL RETARDATION, X-LINKED 32CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneHCFC1C0023903Liver neoplasms1CTD_human
HgeneHCFC1C0345904Malignant neoplasm of liver1CTD_human
HgeneHCFC1C2931498Mental Retardation, X-Linked 11ORPHANET