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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HIP1-ALK (FusionGDB2 ID:HG3092TG238)

Fusion Gene Summary for HIP1-ALK

Fusion gene summary

Fusion gene information	Fusion gene name: HIP1-ALK
	Fusion gene ID: hg3092tg238
		Hgene	Tgene
	Gene symbol	HIP1	ALK
	Gene ID	3092	238
	Gene name	huntingtin interacting protein 1	ALK receptor tyrosine kinase
	Synonyms	HIP-I\|ILWEQ\|SHON\|SHONbeta\|SHONgamma	CD246\|NBLST3
	Cytomap	('HIP1')('ALK') 7q11.23	2p23.2-p23.1
	Type of gene	protein-coding	protein-coding
	Description	huntingtin-interacting protein 1huntingtin-interacting protein I	ALK tyrosine kinase receptorCD246 antigenanaplastic lymphoma receptor tyrosine kinasemutant anaplastic lymphoma kinase
	Modification date	20200313	20200329
	UniProtAcc	O00291	Q9UM73
	Ensembl transtripts involved in fusion gene	ENST00000336926, ENST00000434438, ENST00000479835,
Fusion gene scores	* DoF score	6 X 9 X 5=270	56 X 74 X 20=82880
	# samples	7	57
	** MAII score	log2(7/270*10)=-1.94753258010586 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(57/82880*10)=-7.18391827352181 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HIP1 [Title/Abstract] AND ALK [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HIP1(75183402)-ALK(29446405), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HIP1	GO:0006915	apoptotic process	11788820
Hgene	HIP1	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	11788820
Hgene	HIP1	GO:0042981	regulation of apoptotic process	11788820
Hgene	HIP1	GO:0048268	clathrin coat assembly	11577110\|11889126
Hgene	HIP1	GO:0050821	protein stabilization	14732715
Hgene	HIP1	GO:0097190	apoptotic signaling pathway	11007801
Tgene	ALK	GO:0016310	phosphorylation	9174053
Tgene	ALK	GO:0046777	protein autophosphorylation	9174053

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	HIP1	chr7	75168642	-	ALK	chr2	29446394	-
ChimerKB3	.	.	HIP1	chr7	75172169	-	ALK	chr2	29446394	-
ChimerKB3	.	.	HIP1	chr7	75183411	-	ALK	chr2	29446394	-
ChiTaRS5.0	N/A	KF360988	HIP1	chr7	75183402	-	ALK	chr2	29446405	-

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Fusion Gene ORF analysis for HIP1-ALK

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000336926	ENST00000431873	HIP1	chr7	75168642	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000336926	ENST00000431873	HIP1	chr7	75172169	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000336926	ENST00000431873	HIP1	chr7	75183411	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000336926	ENST00000498037	HIP1	chr7	75168642	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000336926	ENST00000498037	HIP1	chr7	75172169	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000336926	ENST00000498037	HIP1	chr7	75183411	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000434438	ENST00000431873	HIP1	chr7	75168642	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000434438	ENST00000431873	HIP1	chr7	75172169	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000434438	ENST00000431873	HIP1	chr7	75183411	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000434438	ENST00000498037	HIP1	chr7	75168642	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000434438	ENST00000498037	HIP1	chr7	75172169	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000434438	ENST00000498037	HIP1	chr7	75183411	-	ALK	chr2	29446394	-
In-frame	ENST00000336926	ENST00000389048	HIP1	chr7	75168642	-	ALK	chr2	29446394	-
In-frame	ENST00000336926	ENST00000389048	HIP1	chr7	75172169	-	ALK	chr2	29446394	-
In-frame	ENST00000336926	ENST00000389048	HIP1	chr7	75183411	-	ALK	chr2	29446394	-
In-frame	ENST00000434438	ENST00000389048	HIP1	chr7	75168642	-	ALK	chr2	29446394	-
In-frame	ENST00000434438	ENST00000389048	HIP1	chr7	75172169	-	ALK	chr2	29446394	-
In-frame	ENST00000434438	ENST00000389048	HIP1	chr7	75183411	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000479835	ENST00000389048	HIP1	chr7	75168642	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000479835	ENST00000389048	HIP1	chr7	75172169	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000479835	ENST00000389048	HIP1	chr7	75183411	-	ALK	chr2	29446394	-
intron-intron	ENST00000336926	ENST00000389048	HIP1	chr7	75183402	-	ALK	chr2	29446405	-
intron-intron	ENST00000336926	ENST00000431873	HIP1	chr7	75183402	-	ALK	chr2	29446405	-
intron-intron	ENST00000336926	ENST00000498037	HIP1	chr7	75183402	-	ALK	chr2	29446405	-
intron-intron	ENST00000434438	ENST00000389048	HIP1	chr7	75183402	-	ALK	chr2	29446405	-
intron-intron	ENST00000434438	ENST00000431873	HIP1	chr7	75183402	-	ALK	chr2	29446405	-
intron-intron	ENST00000434438	ENST00000498037	HIP1	chr7	75183402	-	ALK	chr2	29446405	-
intron-intron	ENST00000479835	ENST00000389048	HIP1	chr7	75183402	-	ALK	chr2	29446405	-
intron-intron	ENST00000479835	ENST00000431873	HIP1	chr7	75168642	-	ALK	chr2	29446394	-
intron-intron	ENST00000479835	ENST00000431873	HIP1	chr7	75172169	-	ALK	chr2	29446394	-
intron-intron	ENST00000479835	ENST00000431873	HIP1	chr7	75183411	-	ALK	chr2	29446394	-
intron-intron	ENST00000479835	ENST00000431873	HIP1	chr7	75183402	-	ALK	chr2	29446405	-
intron-intron	ENST00000479835	ENST00000498037	HIP1	chr7	75168642	-	ALK	chr2	29446394	-
intron-intron	ENST00000479835	ENST00000498037	HIP1	chr7	75172169	-	ALK	chr2	29446394	-
intron-intron	ENST00000479835	ENST00000498037	HIP1	chr7	75183411	-	ALK	chr2	29446394	-
intron-intron	ENST00000479835	ENST00000498037	HIP1	chr7	75183402	-	ALK	chr2	29446405	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000336926	HIP1	chr7	75168642	-	ENST00000389048	ALK	chr2	29446394	-	5229	3088	27	4778	1583
ENST00000434438	HIP1	chr7	75168642	-	ENST00000389048	ALK	chr2	29446394	-	5070	2929	21	4619	1532
ENST00000336926	HIP1	chr7	75172169	-	ENST00000389048	ALK	chr2	29446394	-	5058	2917	27	4607	1526
ENST00000434438	HIP1	chr7	75172169	-	ENST00000389048	ALK	chr2	29446394	-	4899	2758	21	4448	1475
ENST00000336926	HIP1	chr7	75183411	-	ENST00000389048	ALK	chr2	29446394	-	4326	2185	27	3875	1282
ENST00000434438	HIP1	chr7	75183411	-	ENST00000389048	ALK	chr2	29446394	-	4320	2179	21	3869	1282

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for HIP1-ALK

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

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Fusion Protein Features for HIP1-ALK

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:75183402/chr2:29446405)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HIP1 O00291	ALK Q9UM73
FUNCTION: Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454). {ECO:0000250\|UniProtKB:Q8VD75, ECO:0000269\|PubMed:11007801, ECO:0000269\|PubMed:11532990, ECO:0000269\|PubMed:11577110, ECO:0000269\|PubMed:11889126, ECO:0000269\|PubMed:12163454, ECO:0000269\|PubMed:14732715, ECO:0000269\|PubMed:16027218, ECO:0000269\|PubMed:18790740, ECO:0000269\|PubMed:9147654}.	FUNCTION: Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK. Thinness gene involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). {ECO:0000250\|UniProtKB:P97793, ECO:0000269\|PubMed:11121404, ECO:0000269\|PubMed:11278720, ECO:0000269\|PubMed:11387242, ECO:0000269\|PubMed:11809760, ECO:0000269\|PubMed:12107166, ECO:0000269\|PubMed:12122009, ECO:0000269\|PubMed:15226403, ECO:0000269\|PubMed:15908427, ECO:0000269\|PubMed:16317043, ECO:0000269\|PubMed:16878150, ECO:0000269\|PubMed:17274988}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for HIP1-ALK

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>36380_36380_1_HIP1-ALK_HIP1_chr7_75168642_ENST00000336926_ALK_chr2_29446394_ENST00000389048_length(transcript)=5229nt_BP=3088nt
GCCCCTGACTCGGCTCCTCGCGGCGACATGGATCGGATGGCCAGCTCCATGAAGCAGGTGCCCAACCCACTGCCCAAGGTGCTGAGCCGG
CGCGGGGTCGGCGCTGGGCTGGAGGCGGCGGAGCGCGAGAGCTTCGAGCGGACTCAGACTGTCAGCATCAATAAGGCCATTAATACGCAG
GAAGTGGCTGTAAAGGAAAAACACGCCAGAACGTGCATACTGGGCACCCACCATGAGAAAGGGGCACAGACCTTCTGGTCTGTTGTCAAC
CGCCTGCCTCTGTCTAGCAACGCAGTGCTCTGCTGGAAGTTCTGCCATGTGTTCCACAAACTCCTCCGAGATGGACACCCGAACGTCCTG
AAGGACTCTCTGAGATACAGAAATGAATTGAGTGACATGAGCAGGATGTGGGGCCACCTGAGCGAGGGGTATGGCCAGCTGTGCAGCATC
TACCTGAAACTGCTAAGAACCAAGATGGAGTACCACACCAAAAATCCCAGGTTCCCAGGCAACCTGCAGATGAGTGACCGCCAGCTGGAC
GAGGCTGGAGAAAGTGACGTGAACAACTTTTTCCAGTTAACAGTGGAGATGTTTGACTACCTGGAGTGTGAACTCAACCTCTTCCAAACA
GTATTCAACTCCCTGGACATGTCCCGCTCTGTGTCCGTGACGGCAGCAGGGCAGTGCCGCCTCGCCCCGCTGATCCAGGTCATCTTGGAC
TGCAGCCACCTTTATGACTACACTGTCAAGCTTCTCTTCAAACTCCACTCCTGCCTCCCAGCTGACACCCTGCAAGGCCACCGGGACCGC
TTCATGGAGCAGTTTACAAAGTTGAAAGATCTGTTCTACCGCTCCAGCAACCTGCAGTACTTCAAGCGGCTCATTCAGATCCCCCAGCTG
CCTGAGAACCCACCCAACTTCCTGCGAGCCTCAGCCCTGTCAGAACATATCAGCCCTGTGGTGGTGATCCCTGCAGAGGCCTCATCCCCC
GACAGCGAGCCAGTCCTAGAGAAGGATGACCTCATGGACATGGATGCCTCTCAGCAGAATTTATTTGACAACAAGTTTGATGACATCTTT
GGCAGTTCATTCAGCAGTGATCCCTTCAATTTCAACAGTCAAAATGGTGTGAACAAGGATGAGAAGGACCACTTAATTGAGCGACTATAC
AGAGAGATCAGTGGATTGAAGGCACAGCTAGAAAACATGAAGACTGAGAGCCAGCGGGTTGTGCTGCAGCTGAAGGGCCACGTCAGCGAG
CTGGAAGCAGATCTGGCCGAGCAGCAGCACCTGCGGCAGCAGGCGGCCGACGACTGTGAATTCCTGCGGGCAGAACTGGACGAGCTCAGG
AGGCAGCGGGAGGACACCGAGAAGGCTCAGCGGAGCCTGTCTGAGATAGAAAGGAAAGCTCAAGCCAATGAACAGCGATATAGCAAGCTA
AAGGAGAAGTACAGCGAGCTGGTTCAGAACCACGCTGACCTGCTGCGGAAGAATGCAGAGGTGACCAAACAGGTGTCCATGGCCAGACAA
GCCCAGGTAGATTTGGAACGAGAGAAAAAAGAGCTGGAGGATTCGTTGGAGCGCATCAGTGACCAGGGCCAGCGGAAGACTCAAGAACAG
CTGGAAGTTCTAGAGAGCTTGAAGCAGGAACTTGCCACAAGCCAACGGGAGCTTCAGGTTCTGCAAGGCAGCCTGGAAACTTCTGCCCAG
TCAGAAGCAAACTGGGCAGCCGAGTTCGCCGAGCTAGAGAAGGAGCGGGACAGCCTGGTGAGTGGCGCAGCTCATAGGGAGGAGGAATTA
TCTGCTCTTCGGAAAGAACTGCAGGACACTCAGCTCAAACTGGCCAGCACAGAGGAATCTATGTGCCAGCTTGCCAAAGACCAACGAAAA
ATGCTTCTGGTGGGGTCCAGGAAGGCTGCGGAGCAGGTGATACAAGACGCCCTGAACCAGCTTGAAGAACCTCCTCTCATCAGCTGCGCT
GGGTCTGCAGATCACCTCCTCTCCACGGTCACATCCATTTCCAGCTGCATCGAGCAACTGGAGAAAAGCTGGAGCCAGTATCTGGCCTGC
CCAGAAGACATCAGTGGACTTCTCCATTCCATAACCCTGCTGGCCCACTTGACCAGCGACGCCATTGCTCATGGTGCCACCACCTGCCTC
AGAGCCCCACCTGAGCCTGCCGACTCACTGACCGAGGCCTGTAAGCAGTATGGCAGGGAAACCCTCGCCTACCTGGCCTCCCTGGAGGAA
GAGGGAAGCCTTGAGAATGCCGACAGCACAGCCATGAGGAACTGCCTGAGCAAGATCAAGGCCATCGGCGAGGAGCTCCTGCCCAGGGGA
CTGGACATCAAGCAGGAGGAGCTGGGGGACCTGGTGGACAAGGAGATGGCGGCCACTTCAGCTGCTATTGAAACTGCCACGGCCAGAATA
GAGGAGATGCTCAGCAAATCCCGAGCAGGAGACACAGGAGTCAAATTGGAGGTGAATGAAAGGATCCTTGGTTGCTGTACCAGCCTCATG
CAAGCTATTCAGGTGCTCATCGTGGCCTCTAAGGACCTCCAGAGAGAGATTGTGGAGAGCGGCAGGGGTACAGCATCCCCTAAAGAGTTT
TATGCCAAGAACTCTCGATGGACAGAAGGACTTATCTCAGCCTCCAAGGCTGTGGGCTGGGGAGCCACTGTCATGGTGGATGCAGCTGAT
CTGGTGGTACAAGGCAGAGGGAAATTTGAGGAGCTAATGGTGTGTTCTCATGAAATTGCTGCTAGCACAGCCCAGCTTGTGGCTGCATCC
AAGGTGAAAGCTGATAAGGACAGCCCCAACCTAGCCCAGCTGCAGCAGGCCTCTCGGGGAGTGAACCAGGCCACTGCCGGCGTTGTGGCC
TCAACCATTTCCGGCAAATCACAGATCGAAGAGACAGACAACATGGACTTCTCAAGCATGACGCTGACACAGATCAAACGCCAAGAGATG
GATTCTCAGGTTAGGGTGCTAGAGCTAGAAAATGAATTGCAGAAGGAGCGTCAAAAACTGGGAGAGCTTCGGAAAAAGCACTACGAGCTT
GCTGGTGTTGCTGAGGGCTGGGAAGAAGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGATGGAGCTGCAGAGCCCTGAGTAC
AAGCTGAGCAAGCTCCGCACCTCGACCATCATGACCGACTACAACCCCAACTACTGCTTTGCTGGCAAGACCTCCTCCATCAGTGACCTG
AAGGAGGTGCCGCGGAAAAACATCACCCTCATTCGGGGTCTGGGCCATGGCGCCTTTGGGGAGGTGTATGAAGGCCAGGTGTCCGGAATG
CCCAACGACCCAAGCCCCCTGCAAGTGGCTGTGAAGACGCTGCCTGAAGTGTGCTCTGAACAGGACGAACTGGATTTCCTCATGGAAGCC
CTGATCATCAGCAAATTCAACCACCAGAACATTGTTCGCTGCATTGGGGTGAGCCTGCAATCCCTGCCCCGGTTCATCCTGCTGGAGCTC
ATGGCGGGGGGAGACCTCAAGTCCTTCCTCCGAGAGACCCGCCCTCGCCCGAGCCAGCCCTCCTCCCTGGCCATGCTGGACCTTCTGCAC
GTGGCTCGGGACATTGCCTGTGGCTGTCAGTATTTGGAGGAAAACCACTTCATCCACCGAGACATTGCTGCCAGAAACTGCCTCTTGACC
TGTCCAGGCCCTGGAAGAGTGGCCAAGATTGGAGACTTCGGGATGGCCCGAGACATCTACAGGGCGAGCTACTATAGAAAGGGAGGCTGT
GCCATGCTGCCAGTTAAGTGGATGCCCCCAGAGGCCTTCATGGAAGGAATATTCACTTCTAAAACAGACACATGGTCCTTTGGAGTGCTG
CTATGGGAAATCTTTTCTCTTGGATATATGCCATACCCCAGCAAAAGCAACCAGGAAGTTCTGGAGTTTGTCACCAGTGGAGGCCGGATG
GACCCACCCAAGAACTGCCCTGGGCCTGTATACCGGATAATGACTCAGTGCTGGCAACATCAGCCTGAAGACAGGCCCAACTTTGCCATC
ATTTTGGAGAGGATTGAATACTGCACCCAGGACCCGGATGTAATCAACACCGCTTTGCCGATAGAATATGGTCCACTTGTGGAAGAGGAA
GAGAAAGTGCCTGTGAGGCCCAAGGACCCTGAGGGGGTTCCTCCTCTCCTGGTCTCTCAACAGGCAAAACGGGAGGAGGAGCGCAGCCCA
GCTGCCCCACCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCAGAGATCTCTGTTCGAGTCCCTAGAGGG
CCGGCCGTGGAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTGCACAAGGTCCACGGATCCAGAAACAAG
CCCACCAGCTTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAGAATAATCCTATAGCAAAGAAGGAGCCACAC
GACAGGGGTAACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACTGGGAGACTTCCGGGGGCCTCACTGCTCCTAGAG
CCCTCTTCGCTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGTGGGAATGTCAATTACGGCTACCAGCAA
CAGGGCTTGCCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACCATTCTGAAAAGCAAGAATAGCATGAACCAGCCT
GGGCCCTGAGCTCGGTCGCACACTCACTTCTCTTCCTTGGGATCCCTAAGACCGTGGAGGAGAGAGAGGCAATGGCTCCTTCACAAACCA
GAGACCAAATGTCACGTTTTGTTTTGTGCCAACCTATTTTGAAGTACCACCAAAAAAGCTGTATTTTGAAAATGCTTTAGAAAGGTTTTG
AGCATGGGTTCATCCTATTCTTTCGAAAGAAGAAAATATCATAAAAATGAGTGATAAATACAAGGCCCAGATGTGGTTGCATAAGGTTTT
TATGCATGTTTGTTGTATACTTCCTTATGCTTCTTTCAAATTGTGTGTGCTCTGCTTCAATGTAGTCAGAATTAGCTGCTTCTATGTTTC
ATAGTTGGGGTCATAGATGTTTCCTTGCCTTGTTGATGTGGACATGAGCCATTTGAGGGGAGAGGGAACGGAAATAAAGGAGTTATTTGT

>36380_36380_1_HIP1-ALK_HIP1_chr7_75168642_ENST00000336926_ALK_chr2_29446394_ENST00000389048_length(amino acids)=1583AA_BP=1020
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSSNAV
LCWKFCHVFHKLLRDGHPNVLKDSLRYRNELSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNN
FFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLK
DLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPF
NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKA
QRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQ
ELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKA
AEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADS
LTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRA
GDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKF
EELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLEL
ENELQKERQKLGELRKKHYELAGVAEGWEEVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNIT
LIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSF
LRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMP
PEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCT
QDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVN
MAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMK

--------------------------------------------------------------
>36380_36380_2_HIP1-ALK_HIP1_chr7_75168642_ENST00000434438_ALK_chr2_29446394_ENST00000389048_length(transcript)=5070nt_BP=2929nt
GACTCGGCTCCTCGCGGCGACATGGATCGGATGGCCAGCTCCATGAAGCAGGTGCCCAACCCACTGCCCAAGGTGCTGAGCCGGCGCGGG
GTCGGCGCTGGGCTGGAGGCGGCGGAGCGCGAGAGCTTCGAGCGGACTCAGACTGTCAGCATCAATAAGGCCATTAATACGCAGGAAGTG
GCTGTAAAGGAAAAACACGCCAGAACGTGCATACTGGGCACCCACCATGAGAAAGGGGCACAGACCTTCTGGTCTGTTGTCAACCGCCTG
CCTCTGTCTAGCAACGCAGTGCTCTGCTGGAAGTTCTGCCATGTGTTCCACAAACTCCTCCGAGATGGACACCCGAACGTCCTGAAGGAC
TCTCTGAGATACAGAAATGAATTGAGTGACATGAGCAGGATGTGGGGCCACCTGAGCGAGGGGTATGGCCAGCTGTGCAGCATCTACCTG
AAACTGCTAAGAACCAAGATGGAGTACCACACCAAAAATCCCAGGTTCCCAGGCAACCTGCAGATGAGTGACCGCCAGCTGGACGAGGCT
GGAGAAAGTGACGTGAACAACTTTTTCCAGTTAACAGTGGAGATGTTTGACTACCTGGAGTGTGAACTCAACCTCTTCCAAACAGTATTC
AACTCCCTGGACATGTCCCGCTCTGTGTCCGTGACGGCAGCAGGGCAGTGCCGCCTCGCCCCGCTGATCCAGGTCATCTTGGACTGCAGC
CACCTTTATGACTACACTGTCAAGCTTCTCTTCAAACTCCACTCCTGCCTCCCAGCTGACACCCTGCAAGGCCACCGGGACCGCTTCATG
GAGCAGTTTACAAAGTTGAAAGATCTGTTCTACCGCTCCAGCAACCTGCAGTACTTCAAGCGGCTCATTCAGATCCCCCAGCTGCCTGAG
AACCCACCCAACTTCCTGCGAGCCTCAGCCCTGTCAGAACATATCAGCCCTGTGGTGGTGATCCCTGCAGAGGCCTCATCCCCCGACAGC
GAGCCAGTCCTAGAGAAGGATGACCTCATGGACATGGATGCCTCTCAGCAGAATTTATTTGACAACAAGTTTGATGACATCTTTGGCAGT
TCATTCAGCAGTGATCCCTTCAATTTCAACAGTCAAAATGGTGTGAACAAGGATGAGAAGGACCACTTAATTGAGCGACTATACAGAGAG
ATCAGTGGATTGAAGGCACAGCTAGAAAACATGAAGACTGAGAGCCAGCGGGTTGTGCTGCAGCTGAAGGGCCACGTCAGCGAGCTGGAA
GCAGATCTGGCCGAGCAGCAGCACCTGCGGCAGCAGGCGGCCGACGACTGTGAATTCCTGCGGGCAGAACTGGACGAGCTCAGGAGGCAG
CGGGAGGACACCGAGAAGGCTCAGCGGAGCCTGTCTGAGATAGAAAGGAAAGCTCAAGCCAATGAACAGCGATATAGCAAGCTAAAGGAG
AAGTACAGCGAGCTGGTTCAGAACCACGCTGACCTGCTGCGGAAGAATGCAGAGGTGACCAAACAGGTGTCCATGGCCAGACAAGCCCAG
GTAGATTTGGAACGAGAGAAAAAAGAGCTGGAGGATTCGTTGGAGCGCATCAGTGACCAGGGCCAGCGGAAGACTCAAGAACAGCTGGAA
GTTCTAGAGAGCTTGAAGCAGGAACTTGCCACAAGCCAACGGGAGCTTCAGGTTCTGCAAGGCAGCCTGGAAACTTCTGCCCAGTCAGAA
GCAAACTGGGCAGCCGAGTTCGCCGAGCTAGAGAAGGAGCGGGACAGCCTGGTGAGTGGCGCAGCTCATAGGGAGGAGGAATTATCTGCT
CTTCGGAAAGAACTGCAGGACACTCAGCTCAAACTGGCCAGCACAGAGGAATCTATGTGCCAGCTTGCCAAAGACCAACGAAAAATGCTT
CTGGTGGGGTCCAGGAAGGCTGCGGAGCAGGTGATACAAGACGCCCTGAACCAGCTTGAAGAACCTCCTCTCATCAGCTGCGCTGGGTCT
GCAGATCACCTCCTCTCCACGGTCACATCCATTTCCAGCTGCATCGAGCAACTGGAGAAAAGCTGGAGCCAGTATCTGGCCTGCCCAGAA
GACATCAGTGGACTTCTCCATTCCATAACCCTGCTGGCCCACTTGACCAGCGACGCCATTGCTCATGGTGCCACCACCTGCCTCAGAGCC
CCACCTGAGCCTGCCGACTCACTGACCGAGGCCTGTAAGCAGTATGGCAGGGAAACCCTCGCCTACCTGGCCTCCCTGGAGGAAGAGGGA
AGCCTTGAGAATGCCGACAGCACAGCCATGAGGAACTGCCTGAGCAAGATCAAGGCCATCGGCGAGGAGCTCCTGCCCAGGGGACTGGAC
ATCAAGCAGGAGGAGCTGGGGGACCTGGTGGACAAGGAGATGGCGGCCACTTCAGCTGCTATTGAAACTGCCACGGCCAGAATAGAGGGT
ACAGCATCCCCTAAAGAGTTTTATGCCAAGAACTCTCGATGGACAGAAGGACTTATCTCAGCCTCCAAGGCTGTGGGCTGGGGAGCCACT
GTCATGGTGGATGCAGCTGATCTGGTGGTACAAGGCAGAGGGAAATTTGAGGAGCTAATGGTGTGTTCTCATGAAATTGCTGCTAGCACA
GCCCAGCTTGTGGCTGCATCCAAGGTGAAAGCTGATAAGGACAGCCCCAACCTAGCCCAGCTGCAGCAGGCCTCTCGGGGAGTGAACCAG
GCCACTGCCGGCGTTGTGGCCTCAACCATTTCCGGCAAATCACAGATCGAAGAGACAGACAACATGGACTTCTCAAGCATGACGCTGACA
CAGATCAAACGCCAAGAGATGGATTCTCAGGTTAGGGTGCTAGAGCTAGAAAATGAATTGCAGAAGGAGCGTCAAAAACTGGGAGAGCTT
CGGAAAAAGCACTACGAGCTTGCTGGTGTTGCTGAGGGCTGGGAAGAAGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGATG
GAGCTGCAGAGCCCTGAGTACAAGCTGAGCAAGCTCCGCACCTCGACCATCATGACCGACTACAACCCCAACTACTGCTTTGCTGGCAAG
ACCTCCTCCATCAGTGACCTGAAGGAGGTGCCGCGGAAAAACATCACCCTCATTCGGGGTCTGGGCCATGGCGCCTTTGGGGAGGTGTAT
GAAGGCCAGGTGTCCGGAATGCCCAACGACCCAAGCCCCCTGCAAGTGGCTGTGAAGACGCTGCCTGAAGTGTGCTCTGAACAGGACGAA
CTGGATTTCCTCATGGAAGCCCTGATCATCAGCAAATTCAACCACCAGAACATTGTTCGCTGCATTGGGGTGAGCCTGCAATCCCTGCCC
CGGTTCATCCTGCTGGAGCTCATGGCGGGGGGAGACCTCAAGTCCTTCCTCCGAGAGACCCGCCCTCGCCCGAGCCAGCCCTCCTCCCTG
GCCATGCTGGACCTTCTGCACGTGGCTCGGGACATTGCCTGTGGCTGTCAGTATTTGGAGGAAAACCACTTCATCCACCGAGACATTGCT
GCCAGAAACTGCCTCTTGACCTGTCCAGGCCCTGGAAGAGTGGCCAAGATTGGAGACTTCGGGATGGCCCGAGACATCTACAGGGCGAGC
TACTATAGAAAGGGAGGCTGTGCCATGCTGCCAGTTAAGTGGATGCCCCCAGAGGCCTTCATGGAAGGAATATTCACTTCTAAAACAGAC
ACATGGTCCTTTGGAGTGCTGCTATGGGAAATCTTTTCTCTTGGATATATGCCATACCCCAGCAAAAGCAACCAGGAAGTTCTGGAGTTT
GTCACCAGTGGAGGCCGGATGGACCCACCCAAGAACTGCCCTGGGCCTGTATACCGGATAATGACTCAGTGCTGGCAACATCAGCCTGAA
GACAGGCCCAACTTTGCCATCATTTTGGAGAGGATTGAATACTGCACCCAGGACCCGGATGTAATCAACACCGCTTTGCCGATAGAATAT
GGTCCACTTGTGGAAGAGGAAGAGAAAGTGCCTGTGAGGCCCAAGGACCCTGAGGGGGTTCCTCCTCTCCTGGTCTCTCAACAGGCAAAA
CGGGAGGAGGAGCGCAGCCCAGCTGCCCCACCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCAGAGATC
TCTGTTCGAGTCCCTAGAGGGCCGGCCGTGGAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTGCACAAG
GTCCACGGATCCAGAAACAAGCCCACCAGCTTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAGAATAATCCT
ATAGCAAAGAAGGAGCCACACGACAGGGGTAACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACTGGGAGACTTCCG
GGGGCCTCACTGCTCCTAGAGCCCTCTTCGCTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGTGGGAAT
GTCAATTACGGCTACCAGCAACAGGGCTTGCCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACCATTCTGAAAAGC
AAGAATAGCATGAACCAGCCTGGGCCCTGAGCTCGGTCGCACACTCACTTCTCTTCCTTGGGATCCCTAAGACCGTGGAGGAGAGAGAGG
CAATGGCTCCTTCACAAACCAGAGACCAAATGTCACGTTTTGTTTTGTGCCAACCTATTTTGAAGTACCACCAAAAAAGCTGTATTTTGA
AAATGCTTTAGAAAGGTTTTGAGCATGGGTTCATCCTATTCTTTCGAAAGAAGAAAATATCATAAAAATGAGTGATAAATACAAGGCCCA
GATGTGGTTGCATAAGGTTTTTATGCATGTTTGTTGTATACTTCCTTATGCTTCTTTCAAATTGTGTGTGCTCTGCTTCAATGTAGTCAG
AATTAGCTGCTTCTATGTTTCATAGTTGGGGTCATAGATGTTTCCTTGCCTTGTTGATGTGGACATGAGCCATTTGAGGGGAGAGGGAAC

>36380_36380_2_HIP1-ALK_HIP1_chr7_75168642_ENST00000434438_ALK_chr2_29446394_ENST00000389048_length(amino acids)=1532AA_BP=969
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSSNAV
LCWKFCHVFHKLLRDGHPNVLKDSLRYRNELSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNN
FFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLK
DLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPF
NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKA
QRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQ
ELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKA
AEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADS
LTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEGTASPKEF
YAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVA
STISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEVYRRKHQELQAMQMELQSPEY
KLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEA
LIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLT
CPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRM
DPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSP
AAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPH
DRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQP

--------------------------------------------------------------
>36380_36380_3_HIP1-ALK_HIP1_chr7_75172169_ENST00000336926_ALK_chr2_29446394_ENST00000389048_length(transcript)=5058nt_BP=2917nt
GCCCCTGACTCGGCTCCTCGCGGCGACATGGATCGGATGGCCAGCTCCATGAAGCAGGTGCCCAACCCACTGCCCAAGGTGCTGAGCCGG
CGCGGGGTCGGCGCTGGGCTGGAGGCGGCGGAGCGCGAGAGCTTCGAGCGGACTCAGACTGTCAGCATCAATAAGGCCATTAATACGCAG
GAAGTGGCTGTAAAGGAAAAACACGCCAGAACGTGCATACTGGGCACCCACCATGAGAAAGGGGCACAGACCTTCTGGTCTGTTGTCAAC
CGCCTGCCTCTGTCTAGCAACGCAGTGCTCTGCTGGAAGTTCTGCCATGTGTTCCACAAACTCCTCCGAGATGGACACCCGAACGTCCTG
AAGGACTCTCTGAGATACAGAAATGAATTGAGTGACATGAGCAGGATGTGGGGCCACCTGAGCGAGGGGTATGGCCAGCTGTGCAGCATC
TACCTGAAACTGCTAAGAACCAAGATGGAGTACCACACCAAAAATCCCAGGTTCCCAGGCAACCTGCAGATGAGTGACCGCCAGCTGGAC
GAGGCTGGAGAAAGTGACGTGAACAACTTTTTCCAGTTAACAGTGGAGATGTTTGACTACCTGGAGTGTGAACTCAACCTCTTCCAAACA
GTATTCAACTCCCTGGACATGTCCCGCTCTGTGTCCGTGACGGCAGCAGGGCAGTGCCGCCTCGCCCCGCTGATCCAGGTCATCTTGGAC
TGCAGCCACCTTTATGACTACACTGTCAAGCTTCTCTTCAAACTCCACTCCTGCCTCCCAGCTGACACCCTGCAAGGCCACCGGGACCGC
TTCATGGAGCAGTTTACAAAGTTGAAAGATCTGTTCTACCGCTCCAGCAACCTGCAGTACTTCAAGCGGCTCATTCAGATCCCCCAGCTG
CCTGAGAACCCACCCAACTTCCTGCGAGCCTCAGCCCTGTCAGAACATATCAGCCCTGTGGTGGTGATCCCTGCAGAGGCCTCATCCCCC
GACAGCGAGCCAGTCCTAGAGAAGGATGACCTCATGGACATGGATGCCTCTCAGCAGAATTTATTTGACAACAAGTTTGATGACATCTTT
GGCAGTTCATTCAGCAGTGATCCCTTCAATTTCAACAGTCAAAATGGTGTGAACAAGGATGAGAAGGACCACTTAATTGAGCGACTATAC
AGAGAGATCAGTGGATTGAAGGCACAGCTAGAAAACATGAAGACTGAGAGCCAGCGGGTTGTGCTGCAGCTGAAGGGCCACGTCAGCGAG
CTGGAAGCAGATCTGGCCGAGCAGCAGCACCTGCGGCAGCAGGCGGCCGACGACTGTGAATTCCTGCGGGCAGAACTGGACGAGCTCAGG
AGGCAGCGGGAGGACACCGAGAAGGCTCAGCGGAGCCTGTCTGAGATAGAAAGGAAAGCTCAAGCCAATGAACAGCGATATAGCAAGCTA
AAGGAGAAGTACAGCGAGCTGGTTCAGAACCACGCTGACCTGCTGCGGAAGAATGCAGAGGTGACCAAACAGGTGTCCATGGCCAGACAA
GCCCAGGTAGATTTGGAACGAGAGAAAAAAGAGCTGGAGGATTCGTTGGAGCGCATCAGTGACCAGGGCCAGCGGAAGACTCAAGAACAG
CTGGAAGTTCTAGAGAGCTTGAAGCAGGAACTTGCCACAAGCCAACGGGAGCTTCAGGTTCTGCAAGGCAGCCTGGAAACTTCTGCCCAG
TCAGAAGCAAACTGGGCAGCCGAGTTCGCCGAGCTAGAGAAGGAGCGGGACAGCCTGGTGAGTGGCGCAGCTCATAGGGAGGAGGAATTA
TCTGCTCTTCGGAAAGAACTGCAGGACACTCAGCTCAAACTGGCCAGCACAGAGGAATCTATGTGCCAGCTTGCCAAAGACCAACGAAAA
ATGCTTCTGGTGGGGTCCAGGAAGGCTGCGGAGCAGGTGATACAAGACGCCCTGAACCAGCTTGAAGAACCTCCTCTCATCAGCTGCGCT
GGGTCTGCAGATCACCTCCTCTCCACGGTCACATCCATTTCCAGCTGCATCGAGCAACTGGAGAAAAGCTGGAGCCAGTATCTGGCCTGC
CCAGAAGACATCAGTGGACTTCTCCATTCCATAACCCTGCTGGCCCACTTGACCAGCGACGCCATTGCTCATGGTGCCACCACCTGCCTC
AGAGCCCCACCTGAGCCTGCCGACTCACTGACCGAGGCCTGTAAGCAGTATGGCAGGGAAACCCTCGCCTACCTGGCCTCCCTGGAGGAA
GAGGGAAGCCTTGAGAATGCCGACAGCACAGCCATGAGGAACTGCCTGAGCAAGATCAAGGCCATCGGCGAGGAGCTCCTGCCCAGGGGA
CTGGACATCAAGCAGGAGGAGCTGGGGGACCTGGTGGACAAGGAGATGGCGGCCACTTCAGCTGCTATTGAAACTGCCACGGCCAGAATA
GAGGAGATGCTCAGCAAATCCCGAGCAGGAGACACAGGAGTCAAATTGGAGGTGAATGAAAGGATCCTTGGTTGCTGTACCAGCCTCATG
CAAGCTATTCAGGTGCTCATCGTGGCCTCTAAGGACCTCCAGAGAGAGATTGTGGAGAGCGGCAGGGGTACAGCATCCCCTAAAGAGTTT
TATGCCAAGAACTCTCGATGGACAGAAGGACTTATCTCAGCCTCCAAGGCTGTGGGCTGGGGAGCCACTGTCATGGTGGATGCAGCTGAT
CTGGTGGTACAAGGCAGAGGGAAATTTGAGGAGCTAATGGTGTGTTCTCATGAAATTGCTGCTAGCACAGCCCAGCTTGTGGCTGCATCC
AAGGTGAAAGCTGATAAGGACAGCCCCAACCTAGCCCAGCTGCAGCAGGCCTCTCGGGGAGTGAACCAGGCCACTGCCGGCGTTGTGGCC
TCAACCATTTCCGGCAAATCACAGATCGAAGAGACAGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGATGGAGCTGCAGAGC
CCTGAGTACAAGCTGAGCAAGCTCCGCACCTCGACCATCATGACCGACTACAACCCCAACTACTGCTTTGCTGGCAAGACCTCCTCCATC
AGTGACCTGAAGGAGGTGCCGCGGAAAAACATCACCCTCATTCGGGGTCTGGGCCATGGCGCCTTTGGGGAGGTGTATGAAGGCCAGGTG
TCCGGAATGCCCAACGACCCAAGCCCCCTGCAAGTGGCTGTGAAGACGCTGCCTGAAGTGTGCTCTGAACAGGACGAACTGGATTTCCTC
ATGGAAGCCCTGATCATCAGCAAATTCAACCACCAGAACATTGTTCGCTGCATTGGGGTGAGCCTGCAATCCCTGCCCCGGTTCATCCTG
CTGGAGCTCATGGCGGGGGGAGACCTCAAGTCCTTCCTCCGAGAGACCCGCCCTCGCCCGAGCCAGCCCTCCTCCCTGGCCATGCTGGAC
CTTCTGCACGTGGCTCGGGACATTGCCTGTGGCTGTCAGTATTTGGAGGAAAACCACTTCATCCACCGAGACATTGCTGCCAGAAACTGC
CTCTTGACCTGTCCAGGCCCTGGAAGAGTGGCCAAGATTGGAGACTTCGGGATGGCCCGAGACATCTACAGGGCGAGCTACTATAGAAAG
GGAGGCTGTGCCATGCTGCCAGTTAAGTGGATGCCCCCAGAGGCCTTCATGGAAGGAATATTCACTTCTAAAACAGACACATGGTCCTTT
GGAGTGCTGCTATGGGAAATCTTTTCTCTTGGATATATGCCATACCCCAGCAAAAGCAACCAGGAAGTTCTGGAGTTTGTCACCAGTGGA
GGCCGGATGGACCCACCCAAGAACTGCCCTGGGCCTGTATACCGGATAATGACTCAGTGCTGGCAACATCAGCCTGAAGACAGGCCCAAC
TTTGCCATCATTTTGGAGAGGATTGAATACTGCACCCAGGACCCGGATGTAATCAACACCGCTTTGCCGATAGAATATGGTCCACTTGTG
GAAGAGGAAGAGAAAGTGCCTGTGAGGCCCAAGGACCCTGAGGGGGTTCCTCCTCTCCTGGTCTCTCAACAGGCAAAACGGGAGGAGGAG
CGCAGCCCAGCTGCCCCACCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCAGAGATCTCTGTTCGAGTC
CCTAGAGGGCCGGCCGTGGAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTGCACAAGGTCCACGGATCC
AGAAACAAGCCCACCAGCTTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAGAATAATCCTATAGCAAAGAAG
GAGCCACACGACAGGGGTAACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACTGGGAGACTTCCGGGGGCCTCACTG
CTCCTAGAGCCCTCTTCGCTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGTGGGAATGTCAATTACGGC
TACCAGCAACAGGGCTTGCCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACCATTCTGAAAAGCAAGAATAGCATG
AACCAGCCTGGGCCCTGAGCTCGGTCGCACACTCACTTCTCTTCCTTGGGATCCCTAAGACCGTGGAGGAGAGAGAGGCAATGGCTCCTT
CACAAACCAGAGACCAAATGTCACGTTTTGTTTTGTGCCAACCTATTTTGAAGTACCACCAAAAAAGCTGTATTTTGAAAATGCTTTAGA
AAGGTTTTGAGCATGGGTTCATCCTATTCTTTCGAAAGAAGAAAATATCATAAAAATGAGTGATAAATACAAGGCCCAGATGTGGTTGCA
TAAGGTTTTTATGCATGTTTGTTGTATACTTCCTTATGCTTCTTTCAAATTGTGTGTGCTCTGCTTCAATGTAGTCAGAATTAGCTGCTT
CTATGTTTCATAGTTGGGGTCATAGATGTTTCCTTGCCTTGTTGATGTGGACATGAGCCATTTGAGGGGAGAGGGAACGGAAATAAAGGA

>36380_36380_3_HIP1-ALK_HIP1_chr7_75172169_ENST00000336926_ALK_chr2_29446394_ENST00000389048_length(amino acids)=1526AA_BP=963
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSSNAV
LCWKFCHVFHKLLRDGHPNVLKDSLRYRNELSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNN
FFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLK
DLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPF
NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKA
QRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQ
ELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKA
AEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADS
LTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRA
GDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKF
EELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETVYRRKHQELQAMQMELQSPEYKLSKLR
TSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKF
NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGR
VAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNC
PGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPL
PTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLG

--------------------------------------------------------------
>36380_36380_4_HIP1-ALK_HIP1_chr7_75172169_ENST00000434438_ALK_chr2_29446394_ENST00000389048_length(transcript)=4899nt_BP=2758nt
GACTCGGCTCCTCGCGGCGACATGGATCGGATGGCCAGCTCCATGAAGCAGGTGCCCAACCCACTGCCCAAGGTGCTGAGCCGGCGCGGG
GTCGGCGCTGGGCTGGAGGCGGCGGAGCGCGAGAGCTTCGAGCGGACTCAGACTGTCAGCATCAATAAGGCCATTAATACGCAGGAAGTG
GCTGTAAAGGAAAAACACGCCAGAACGTGCATACTGGGCACCCACCATGAGAAAGGGGCACAGACCTTCTGGTCTGTTGTCAACCGCCTG
CCTCTGTCTAGCAACGCAGTGCTCTGCTGGAAGTTCTGCCATGTGTTCCACAAACTCCTCCGAGATGGACACCCGAACGTCCTGAAGGAC
TCTCTGAGATACAGAAATGAATTGAGTGACATGAGCAGGATGTGGGGCCACCTGAGCGAGGGGTATGGCCAGCTGTGCAGCATCTACCTG
AAACTGCTAAGAACCAAGATGGAGTACCACACCAAAAATCCCAGGTTCCCAGGCAACCTGCAGATGAGTGACCGCCAGCTGGACGAGGCT
GGAGAAAGTGACGTGAACAACTTTTTCCAGTTAACAGTGGAGATGTTTGACTACCTGGAGTGTGAACTCAACCTCTTCCAAACAGTATTC
AACTCCCTGGACATGTCCCGCTCTGTGTCCGTGACGGCAGCAGGGCAGTGCCGCCTCGCCCCGCTGATCCAGGTCATCTTGGACTGCAGC
CACCTTTATGACTACACTGTCAAGCTTCTCTTCAAACTCCACTCCTGCCTCCCAGCTGACACCCTGCAAGGCCACCGGGACCGCTTCATG
GAGCAGTTTACAAAGTTGAAAGATCTGTTCTACCGCTCCAGCAACCTGCAGTACTTCAAGCGGCTCATTCAGATCCCCCAGCTGCCTGAG
AACCCACCCAACTTCCTGCGAGCCTCAGCCCTGTCAGAACATATCAGCCCTGTGGTGGTGATCCCTGCAGAGGCCTCATCCCCCGACAGC
GAGCCAGTCCTAGAGAAGGATGACCTCATGGACATGGATGCCTCTCAGCAGAATTTATTTGACAACAAGTTTGATGACATCTTTGGCAGT
TCATTCAGCAGTGATCCCTTCAATTTCAACAGTCAAAATGGTGTGAACAAGGATGAGAAGGACCACTTAATTGAGCGACTATACAGAGAG
ATCAGTGGATTGAAGGCACAGCTAGAAAACATGAAGACTGAGAGCCAGCGGGTTGTGCTGCAGCTGAAGGGCCACGTCAGCGAGCTGGAA
GCAGATCTGGCCGAGCAGCAGCACCTGCGGCAGCAGGCGGCCGACGACTGTGAATTCCTGCGGGCAGAACTGGACGAGCTCAGGAGGCAG
CGGGAGGACACCGAGAAGGCTCAGCGGAGCCTGTCTGAGATAGAAAGGAAAGCTCAAGCCAATGAACAGCGATATAGCAAGCTAAAGGAG
AAGTACAGCGAGCTGGTTCAGAACCACGCTGACCTGCTGCGGAAGAATGCAGAGGTGACCAAACAGGTGTCCATGGCCAGACAAGCCCAG
GTAGATTTGGAACGAGAGAAAAAAGAGCTGGAGGATTCGTTGGAGCGCATCAGTGACCAGGGCCAGCGGAAGACTCAAGAACAGCTGGAA
GTTCTAGAGAGCTTGAAGCAGGAACTTGCCACAAGCCAACGGGAGCTTCAGGTTCTGCAAGGCAGCCTGGAAACTTCTGCCCAGTCAGAA
GCAAACTGGGCAGCCGAGTTCGCCGAGCTAGAGAAGGAGCGGGACAGCCTGGTGAGTGGCGCAGCTCATAGGGAGGAGGAATTATCTGCT
CTTCGGAAAGAACTGCAGGACACTCAGCTCAAACTGGCCAGCACAGAGGAATCTATGTGCCAGCTTGCCAAAGACCAACGAAAAATGCTT
CTGGTGGGGTCCAGGAAGGCTGCGGAGCAGGTGATACAAGACGCCCTGAACCAGCTTGAAGAACCTCCTCTCATCAGCTGCGCTGGGTCT
GCAGATCACCTCCTCTCCACGGTCACATCCATTTCCAGCTGCATCGAGCAACTGGAGAAAAGCTGGAGCCAGTATCTGGCCTGCCCAGAA
GACATCAGTGGACTTCTCCATTCCATAACCCTGCTGGCCCACTTGACCAGCGACGCCATTGCTCATGGTGCCACCACCTGCCTCAGAGCC
CCACCTGAGCCTGCCGACTCACTGACCGAGGCCTGTAAGCAGTATGGCAGGGAAACCCTCGCCTACCTGGCCTCCCTGGAGGAAGAGGGA
AGCCTTGAGAATGCCGACAGCACAGCCATGAGGAACTGCCTGAGCAAGATCAAGGCCATCGGCGAGGAGCTCCTGCCCAGGGGACTGGAC
ATCAAGCAGGAGGAGCTGGGGGACCTGGTGGACAAGGAGATGGCGGCCACTTCAGCTGCTATTGAAACTGCCACGGCCAGAATAGAGGGT
ACAGCATCCCCTAAAGAGTTTTATGCCAAGAACTCTCGATGGACAGAAGGACTTATCTCAGCCTCCAAGGCTGTGGGCTGGGGAGCCACT
GTCATGGTGGATGCAGCTGATCTGGTGGTACAAGGCAGAGGGAAATTTGAGGAGCTAATGGTGTGTTCTCATGAAATTGCTGCTAGCACA
GCCCAGCTTGTGGCTGCATCCAAGGTGAAAGCTGATAAGGACAGCCCCAACCTAGCCCAGCTGCAGCAGGCCTCTCGGGGAGTGAACCAG
GCCACTGCCGGCGTTGTGGCCTCAACCATTTCCGGCAAATCACAGATCGAAGAGACAGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCC
ATGCAGATGGAGCTGCAGAGCCCTGAGTACAAGCTGAGCAAGCTCCGCACCTCGACCATCATGACCGACTACAACCCCAACTACTGCTTT
GCTGGCAAGACCTCCTCCATCAGTGACCTGAAGGAGGTGCCGCGGAAAAACATCACCCTCATTCGGGGTCTGGGCCATGGCGCCTTTGGG
GAGGTGTATGAAGGCCAGGTGTCCGGAATGCCCAACGACCCAAGCCCCCTGCAAGTGGCTGTGAAGACGCTGCCTGAAGTGTGCTCTGAA
CAGGACGAACTGGATTTCCTCATGGAAGCCCTGATCATCAGCAAATTCAACCACCAGAACATTGTTCGCTGCATTGGGGTGAGCCTGCAA
TCCCTGCCCCGGTTCATCCTGCTGGAGCTCATGGCGGGGGGAGACCTCAAGTCCTTCCTCCGAGAGACCCGCCCTCGCCCGAGCCAGCCC
TCCTCCCTGGCCATGCTGGACCTTCTGCACGTGGCTCGGGACATTGCCTGTGGCTGTCAGTATTTGGAGGAAAACCACTTCATCCACCGA
GACATTGCTGCCAGAAACTGCCTCTTGACCTGTCCAGGCCCTGGAAGAGTGGCCAAGATTGGAGACTTCGGGATGGCCCGAGACATCTAC
AGGGCGAGCTACTATAGAAAGGGAGGCTGTGCCATGCTGCCAGTTAAGTGGATGCCCCCAGAGGCCTTCATGGAAGGAATATTCACTTCT
AAAACAGACACATGGTCCTTTGGAGTGCTGCTATGGGAAATCTTTTCTCTTGGATATATGCCATACCCCAGCAAAAGCAACCAGGAAGTT
CTGGAGTTTGTCACCAGTGGAGGCCGGATGGACCCACCCAAGAACTGCCCTGGGCCTGTATACCGGATAATGACTCAGTGCTGGCAACAT
CAGCCTGAAGACAGGCCCAACTTTGCCATCATTTTGGAGAGGATTGAATACTGCACCCAGGACCCGGATGTAATCAACACCGCTTTGCCG
ATAGAATATGGTCCACTTGTGGAAGAGGAAGAGAAAGTGCCTGTGAGGCCCAAGGACCCTGAGGGGGTTCCTCCTCTCCTGGTCTCTCAA
CAGGCAAAACGGGAGGAGGAGCGCAGCCCAGCTGCCCCACCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCT
GCAGAGATCTCTGTTCGAGTCCCTAGAGGGCCGGCCGTGGAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAG
TTGCACAAGGTCCACGGATCCAGAAACAAGCCCACCAGCTTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAG
AATAATCCTATAGCAAAGAAGGAGCCACACGACAGGGGTAACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACTGGG
AGACTTCCGGGGGCCTCACTGCTCCTAGAGCCCTCTTCGCTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCT
TGTGGGAATGTCAATTACGGCTACCAGCAACAGGGCTTGCCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACCATT
CTGAAAAGCAAGAATAGCATGAACCAGCCTGGGCCCTGAGCTCGGTCGCACACTCACTTCTCTTCCTTGGGATCCCTAAGACCGTGGAGG
AGAGAGAGGCAATGGCTCCTTCACAAACCAGAGACCAAATGTCACGTTTTGTTTTGTGCCAACCTATTTTGAAGTACCACCAAAAAAGCT
GTATTTTGAAAATGCTTTAGAAAGGTTTTGAGCATGGGTTCATCCTATTCTTTCGAAAGAAGAAAATATCATAAAAATGAGTGATAAATA
CAAGGCCCAGATGTGGTTGCATAAGGTTTTTATGCATGTTTGTTGTATACTTCCTTATGCTTCTTTCAAATTGTGTGTGCTCTGCTTCAA
TGTAGTCAGAATTAGCTGCTTCTATGTTTCATAGTTGGGGTCATAGATGTTTCCTTGCCTTGTTGATGTGGACATGAGCCATTTGAGGGG

>36380_36380_4_HIP1-ALK_HIP1_chr7_75172169_ENST00000434438_ALK_chr2_29446394_ENST00000389048_length(amino acids)=1475AA_BP=912
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSSNAV
LCWKFCHVFHKLLRDGHPNVLKDSLRYRNELSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNN
FFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLK
DLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPF
NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKA
QRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQ
ELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKA
AEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADS
LTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEGTASPKEF
YAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVA
STISGKSQIEETVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQV
SGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLD
LLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSF
GVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLV
EEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGS
RNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYG

--------------------------------------------------------------
>36380_36380_5_HIP1-ALK_HIP1_chr7_75183411_ENST00000336926_ALK_chr2_29446394_ENST00000389048_length(transcript)=4326nt_BP=2185nt
GCCCCTGACTCGGCTCCTCGCGGCGACATGGATCGGATGGCCAGCTCCATGAAGCAGGTGCCCAACCCACTGCCCAAGGTGCTGAGCCGG
CGCGGGGTCGGCGCTGGGCTGGAGGCGGCGGAGCGCGAGAGCTTCGAGCGGACTCAGACTGTCAGCATCAATAAGGCCATTAATACGCAG
GAAGTGGCTGTAAAGGAAAAACACGCCAGAACGTGCATACTGGGCACCCACCATGAGAAAGGGGCACAGACCTTCTGGTCTGTTGTCAAC
CGCCTGCCTCTGTCTAGCAACGCAGTGCTCTGCTGGAAGTTCTGCCATGTGTTCCACAAACTCCTCCGAGATGGACACCCGAACGTCCTG
AAGGACTCTCTGAGATACAGAAATGAATTGAGTGACATGAGCAGGATGTGGGGCCACCTGAGCGAGGGGTATGGCCAGCTGTGCAGCATC
TACCTGAAACTGCTAAGAACCAAGATGGAGTACCACACCAAAAATCCCAGGTTCCCAGGCAACCTGCAGATGAGTGACCGCCAGCTGGAC
GAGGCTGGAGAAAGTGACGTGAACAACTTTTTCCAGTTAACAGTGGAGATGTTTGACTACCTGGAGTGTGAACTCAACCTCTTCCAAACA
GTATTCAACTCCCTGGACATGTCCCGCTCTGTGTCCGTGACGGCAGCAGGGCAGTGCCGCCTCGCCCCGCTGATCCAGGTCATCTTGGAC
TGCAGCCACCTTTATGACTACACTGTCAAGCTTCTCTTCAAACTCCACTCCTGCCTCCCAGCTGACACCCTGCAAGGCCACCGGGACCGC
TTCATGGAGCAGTTTACAAAGTTGAAAGATCTGTTCTACCGCTCCAGCAACCTGCAGTACTTCAAGCGGCTCATTCAGATCCCCCAGCTG
CCTGAGAACCCACCCAACTTCCTGCGAGCCTCAGCCCTGTCAGAACATATCAGCCCTGTGGTGGTGATCCCTGCAGAGGCCTCATCCCCC
GACAGCGAGCCAGTCCTAGAGAAGGATGACCTCATGGACATGGATGCCTCTCAGCAGAATTTATTTGACAACAAGTTTGATGACATCTTT
GGCAGTTCATTCAGCAGTGATCCCTTCAATTTCAACAGTCAAAATGGTGTGAACAAGGATGAGAAGGACCACTTAATTGAGCGACTATAC
AGAGAGATCAGTGGATTGAAGGCACAGCTAGAAAACATGAAGACTGAGAGCCAGCGGGTTGTGCTGCAGCTGAAGGGCCACGTCAGCGAG
CTGGAAGCAGATCTGGCCGAGCAGCAGCACCTGCGGCAGCAGGCGGCCGACGACTGTGAATTCCTGCGGGCAGAACTGGACGAGCTCAGG
AGGCAGCGGGAGGACACCGAGAAGGCTCAGCGGAGCCTGTCTGAGATAGAAAGGAAAGCTCAAGCCAATGAACAGCGATATAGCAAGCTA
AAGGAGAAGTACAGCGAGCTGGTTCAGAACCACGCTGACCTGCTGCGGAAGAATGCAGAGGTGACCAAACAGGTGTCCATGGCCAGACAA
GCCCAGGTAGATTTGGAACGAGAGAAAAAAGAGCTGGAGGATTCGTTGGAGCGCATCAGTGACCAGGGCCAGCGGAAGACTCAAGAACAG
CTGGAAGTTCTAGAGAGCTTGAAGCAGGAACTTGCCACAAGCCAACGGGAGCTTCAGGTTCTGCAAGGCAGCCTGGAAACTTCTGCCCAG
TCAGAAGCAAACTGGGCAGCCGAGTTCGCCGAGCTAGAGAAGGAGCGGGACAGCCTGGTGAGTGGCGCAGCTCATAGGGAGGAGGAATTA
TCTGCTCTTCGGAAAGAACTGCAGGACACTCAGCTCAAACTGGCCAGCACAGAGGAATCTATGTGCCAGCTTGCCAAAGACCAACGAAAA
ATGCTTCTGGTGGGGTCCAGGAAGGCTGCGGAGCAGGTGATACAAGACGCCCTGAACCAGCTTGAAGAACCTCCTCTCATCAGCTGCGCT
GGGTCTGCAGATCACCTCCTCTCCACGGTCACATCCATTTCCAGCTGCATCGAGCAACTGGAGAAAAGCTGGAGCCAGTATCTGGCCTGC
CCAGAAGACATCAGTGGACTTCTCCATTCCATAACCCTGCTGGCCCACTTGACCAGCGACGCCATTGCTCATGGTGCCACCACCTGCCTC
AGAGCCCCACCTGAGCCTGCCGACTTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGATGGAGCTGCAGAGCCCTGAGTACAAG
CTGAGCAAGCTCCGCACCTCGACCATCATGACCGACTACAACCCCAACTACTGCTTTGCTGGCAAGACCTCCTCCATCAGTGACCTGAAG
GAGGTGCCGCGGAAAAACATCACCCTCATTCGGGGTCTGGGCCATGGCGCCTTTGGGGAGGTGTATGAAGGCCAGGTGTCCGGAATGCCC
AACGACCCAAGCCCCCTGCAAGTGGCTGTGAAGACGCTGCCTGAAGTGTGCTCTGAACAGGACGAACTGGATTTCCTCATGGAAGCCCTG
ATCATCAGCAAATTCAACCACCAGAACATTGTTCGCTGCATTGGGGTGAGCCTGCAATCCCTGCCCCGGTTCATCCTGCTGGAGCTCATG
GCGGGGGGAGACCTCAAGTCCTTCCTCCGAGAGACCCGCCCTCGCCCGAGCCAGCCCTCCTCCCTGGCCATGCTGGACCTTCTGCACGTG
GCTCGGGACATTGCCTGTGGCTGTCAGTATTTGGAGGAAAACCACTTCATCCACCGAGACATTGCTGCCAGAAACTGCCTCTTGACCTGT
CCAGGCCCTGGAAGAGTGGCCAAGATTGGAGACTTCGGGATGGCCCGAGACATCTACAGGGCGAGCTACTATAGAAAGGGAGGCTGTGCC
ATGCTGCCAGTTAAGTGGATGCCCCCAGAGGCCTTCATGGAAGGAATATTCACTTCTAAAACAGACACATGGTCCTTTGGAGTGCTGCTA
TGGGAAATCTTTTCTCTTGGATATATGCCATACCCCAGCAAAAGCAACCAGGAAGTTCTGGAGTTTGTCACCAGTGGAGGCCGGATGGAC
CCACCCAAGAACTGCCCTGGGCCTGTATACCGGATAATGACTCAGTGCTGGCAACATCAGCCTGAAGACAGGCCCAACTTTGCCATCATT
TTGGAGAGGATTGAATACTGCACCCAGGACCCGGATGTAATCAACACCGCTTTGCCGATAGAATATGGTCCACTTGTGGAAGAGGAAGAG
AAAGTGCCTGTGAGGCCCAAGGACCCTGAGGGGGTTCCTCCTCTCCTGGTCTCTCAACAGGCAAAACGGGAGGAGGAGCGCAGCCCAGCT
GCCCCACCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCAGAGATCTCTGTTCGAGTCCCTAGAGGGCCG
GCCGTGGAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTGCACAAGGTCCACGGATCCAGAAACAAGCCC
ACCAGCTTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAGAATAATCCTATAGCAAAGAAGGAGCCACACGAC
AGGGGTAACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACTGGGAGACTTCCGGGGGCCTCACTGCTCCTAGAGCCC
TCTTCGCTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGTGGGAATGTCAATTACGGCTACCAGCAACAG
GGCTTGCCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACCATTCTGAAAAGCAAGAATAGCATGAACCAGCCTGGG
CCCTGAGCTCGGTCGCACACTCACTTCTCTTCCTTGGGATCCCTAAGACCGTGGAGGAGAGAGAGGCAATGGCTCCTTCACAAACCAGAG
ACCAAATGTCACGTTTTGTTTTGTGCCAACCTATTTTGAAGTACCACCAAAAAAGCTGTATTTTGAAAATGCTTTAGAAAGGTTTTGAGC
ATGGGTTCATCCTATTCTTTCGAAAGAAGAAAATATCATAAAAATGAGTGATAAATACAAGGCCCAGATGTGGTTGCATAAGGTTTTTAT
GCATGTTTGTTGTATACTTCCTTATGCTTCTTTCAAATTGTGTGTGCTCTGCTTCAATGTAGTCAGAATTAGCTGCTTCTATGTTTCATA
GTTGGGGTCATAGATGTTTCCTTGCCTTGTTGATGTGGACATGAGCCATTTGAGGGGAGAGGGAACGGAAATAAAGGAGTTATTTGTAAT

>36380_36380_5_HIP1-ALK_HIP1_chr7_75183411_ENST00000336926_ALK_chr2_29446394_ENST00000389048_length(amino acids)=1282AA_BP=720
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSSNAV
LCWKFCHVFHKLLRDGHPNVLKDSLRYRNELSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNN
FFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLK
DLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPF
NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKA
QRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQ
ELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKA
AEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADL
YRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVA
VKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQ
YLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYM
PYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDP
EGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYG
SWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATA

--------------------------------------------------------------
>36380_36380_6_HIP1-ALK_HIP1_chr7_75183411_ENST00000434438_ALK_chr2_29446394_ENST00000389048_length(transcript)=4320nt_BP=2179nt
GACTCGGCTCCTCGCGGCGACATGGATCGGATGGCCAGCTCCATGAAGCAGGTGCCCAACCCACTGCCCAAGGTGCTGAGCCGGCGCGGG
GTCGGCGCTGGGCTGGAGGCGGCGGAGCGCGAGAGCTTCGAGCGGACTCAGACTGTCAGCATCAATAAGGCCATTAATACGCAGGAAGTG
GCTGTAAAGGAAAAACACGCCAGAACGTGCATACTGGGCACCCACCATGAGAAAGGGGCACAGACCTTCTGGTCTGTTGTCAACCGCCTG
CCTCTGTCTAGCAACGCAGTGCTCTGCTGGAAGTTCTGCCATGTGTTCCACAAACTCCTCCGAGATGGACACCCGAACGTCCTGAAGGAC
TCTCTGAGATACAGAAATGAATTGAGTGACATGAGCAGGATGTGGGGCCACCTGAGCGAGGGGTATGGCCAGCTGTGCAGCATCTACCTG
AAACTGCTAAGAACCAAGATGGAGTACCACACCAAAAATCCCAGGTTCCCAGGCAACCTGCAGATGAGTGACCGCCAGCTGGACGAGGCT
GGAGAAAGTGACGTGAACAACTTTTTCCAGTTAACAGTGGAGATGTTTGACTACCTGGAGTGTGAACTCAACCTCTTCCAAACAGTATTC
AACTCCCTGGACATGTCCCGCTCTGTGTCCGTGACGGCAGCAGGGCAGTGCCGCCTCGCCCCGCTGATCCAGGTCATCTTGGACTGCAGC
CACCTTTATGACTACACTGTCAAGCTTCTCTTCAAACTCCACTCCTGCCTCCCAGCTGACACCCTGCAAGGCCACCGGGACCGCTTCATG
GAGCAGTTTACAAAGTTGAAAGATCTGTTCTACCGCTCCAGCAACCTGCAGTACTTCAAGCGGCTCATTCAGATCCCCCAGCTGCCTGAG
AACCCACCCAACTTCCTGCGAGCCTCAGCCCTGTCAGAACATATCAGCCCTGTGGTGGTGATCCCTGCAGAGGCCTCATCCCCCGACAGC
GAGCCAGTCCTAGAGAAGGATGACCTCATGGACATGGATGCCTCTCAGCAGAATTTATTTGACAACAAGTTTGATGACATCTTTGGCAGT
TCATTCAGCAGTGATCCCTTCAATTTCAACAGTCAAAATGGTGTGAACAAGGATGAGAAGGACCACTTAATTGAGCGACTATACAGAGAG
ATCAGTGGATTGAAGGCACAGCTAGAAAACATGAAGACTGAGAGCCAGCGGGTTGTGCTGCAGCTGAAGGGCCACGTCAGCGAGCTGGAA
GCAGATCTGGCCGAGCAGCAGCACCTGCGGCAGCAGGCGGCCGACGACTGTGAATTCCTGCGGGCAGAACTGGACGAGCTCAGGAGGCAG
CGGGAGGACACCGAGAAGGCTCAGCGGAGCCTGTCTGAGATAGAAAGGAAAGCTCAAGCCAATGAACAGCGATATAGCAAGCTAAAGGAG
AAGTACAGCGAGCTGGTTCAGAACCACGCTGACCTGCTGCGGAAGAATGCAGAGGTGACCAAACAGGTGTCCATGGCCAGACAAGCCCAG
GTAGATTTGGAACGAGAGAAAAAAGAGCTGGAGGATTCGTTGGAGCGCATCAGTGACCAGGGCCAGCGGAAGACTCAAGAACAGCTGGAA
GTTCTAGAGAGCTTGAAGCAGGAACTTGCCACAAGCCAACGGGAGCTTCAGGTTCTGCAAGGCAGCCTGGAAACTTCTGCCCAGTCAGAA
GCAAACTGGGCAGCCGAGTTCGCCGAGCTAGAGAAGGAGCGGGACAGCCTGGTGAGTGGCGCAGCTCATAGGGAGGAGGAATTATCTGCT
CTTCGGAAAGAACTGCAGGACACTCAGCTCAAACTGGCCAGCACAGAGGAATCTATGTGCCAGCTTGCCAAAGACCAACGAAAAATGCTT
CTGGTGGGGTCCAGGAAGGCTGCGGAGCAGGTGATACAAGACGCCCTGAACCAGCTTGAAGAACCTCCTCTCATCAGCTGCGCTGGGTCT
GCAGATCACCTCCTCTCCACGGTCACATCCATTTCCAGCTGCATCGAGCAACTGGAGAAAAGCTGGAGCCAGTATCTGGCCTGCCCAGAA
GACATCAGTGGACTTCTCCATTCCATAACCCTGCTGGCCCACTTGACCAGCGACGCCATTGCTCATGGTGCCACCACCTGCCTCAGAGCC
CCACCTGAGCCTGCCGACTTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGATGGAGCTGCAGAGCCCTGAGTACAAGCTGAGC
AAGCTCCGCACCTCGACCATCATGACCGACTACAACCCCAACTACTGCTTTGCTGGCAAGACCTCCTCCATCAGTGACCTGAAGGAGGTG
CCGCGGAAAAACATCACCCTCATTCGGGGTCTGGGCCATGGCGCCTTTGGGGAGGTGTATGAAGGCCAGGTGTCCGGAATGCCCAACGAC
CCAAGCCCCCTGCAAGTGGCTGTGAAGACGCTGCCTGAAGTGTGCTCTGAACAGGACGAACTGGATTTCCTCATGGAAGCCCTGATCATC
AGCAAATTCAACCACCAGAACATTGTTCGCTGCATTGGGGTGAGCCTGCAATCCCTGCCCCGGTTCATCCTGCTGGAGCTCATGGCGGGG
GGAGACCTCAAGTCCTTCCTCCGAGAGACCCGCCCTCGCCCGAGCCAGCCCTCCTCCCTGGCCATGCTGGACCTTCTGCACGTGGCTCGG
GACATTGCCTGTGGCTGTCAGTATTTGGAGGAAAACCACTTCATCCACCGAGACATTGCTGCCAGAAACTGCCTCTTGACCTGTCCAGGC
CCTGGAAGAGTGGCCAAGATTGGAGACTTCGGGATGGCCCGAGACATCTACAGGGCGAGCTACTATAGAAAGGGAGGCTGTGCCATGCTG
CCAGTTAAGTGGATGCCCCCAGAGGCCTTCATGGAAGGAATATTCACTTCTAAAACAGACACATGGTCCTTTGGAGTGCTGCTATGGGAA
ATCTTTTCTCTTGGATATATGCCATACCCCAGCAAAAGCAACCAGGAAGTTCTGGAGTTTGTCACCAGTGGAGGCCGGATGGACCCACCC
AAGAACTGCCCTGGGCCTGTATACCGGATAATGACTCAGTGCTGGCAACATCAGCCTGAAGACAGGCCCAACTTTGCCATCATTTTGGAG
AGGATTGAATACTGCACCCAGGACCCGGATGTAATCAACACCGCTTTGCCGATAGAATATGGTCCACTTGTGGAAGAGGAAGAGAAAGTG
CCTGTGAGGCCCAAGGACCCTGAGGGGGTTCCTCCTCTCCTGGTCTCTCAACAGGCAAAACGGGAGGAGGAGCGCAGCCCAGCTGCCCCA
CCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCAGAGATCTCTGTTCGAGTCCCTAGAGGGCCGGCCGTG
GAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTGCACAAGGTCCACGGATCCAGAAACAAGCCCACCAGC
TTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAGAATAATCCTATAGCAAAGAAGGAGCCACACGACAGGGGT
AACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACTGGGAGACTTCCGGGGGCCTCACTGCTCCTAGAGCCCTCTTCG
CTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGTGGGAATGTCAATTACGGCTACCAGCAACAGGGCTTG
CCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACCATTCTGAAAAGCAAGAATAGCATGAACCAGCCTGGGCCCTGA
GCTCGGTCGCACACTCACTTCTCTTCCTTGGGATCCCTAAGACCGTGGAGGAGAGAGAGGCAATGGCTCCTTCACAAACCAGAGACCAAA
TGTCACGTTTTGTTTTGTGCCAACCTATTTTGAAGTACCACCAAAAAAGCTGTATTTTGAAAATGCTTTAGAAAGGTTTTGAGCATGGGT
TCATCCTATTCTTTCGAAAGAAGAAAATATCATAAAAATGAGTGATAAATACAAGGCCCAGATGTGGTTGCATAAGGTTTTTATGCATGT
TTGTTGTATACTTCCTTATGCTTCTTTCAAATTGTGTGTGCTCTGCTTCAATGTAGTCAGAATTAGCTGCTTCTATGTTTCATAGTTGGG
GTCATAGATGTTTCCTTGCCTTGTTGATGTGGACATGAGCCATTTGAGGGGAGAGGGAACGGAAATAAAGGAGTTATTTGTAATGACTAA

>36380_36380_6_HIP1-ALK_HIP1_chr7_75183411_ENST00000434438_ALK_chr2_29446394_ENST00000389048_length(amino acids)=1282AA_BP=720
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSSNAV
LCWKFCHVFHKLLRDGHPNVLKDSLRYRNELSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNN
FFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLK
DLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPF
NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKA
QRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQ
ELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKA
AEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADL
YRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVA
VKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQ
YLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYM
PYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDP
EGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYG
SWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATA

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Fusion Gene PPI Analysis for HIP1-ALK

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HIP1-ALK

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	ALK	Q9UM73	DB08865	Crizotinib	Inhibitor	Small molecule	Approved
Tgene	ALK	Q9UM73	DB09063	Ceritinib	Antagonist	Small molecule	Approved
Tgene	ALK	Q9UM73	DB11363	Alectinib	Inhibitor	Small molecule	Approved\|Investigational
Tgene	ALK	Q9UM73	DB12010	Fostamatinib	Inhibitor	Small molecule	Approved\|Investigational
Tgene	ALK	Q9UM73	DB12130	Lorlatinib	Inhibitor	Small molecule	Approved\|Investigational
Tgene	ALK	Q9UM73	DB12141	Gilteritinib	Inhibitor	Small molecule	Approved\|Investigational
Tgene	ALK	Q9UM73	DB12267	Brigatinib	Inhibitor	Small molecule	Approved\|Investigational

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Related Diseases for HIP1-ALK

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HIP1	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene		C0007131	Non-Small Cell Lung Carcinoma	28	CGI;CTD_human
Tgene		C0027819	Neuroblastoma	13	CGI;CTD_human;ORPHANET
Tgene		C0152013	Adenocarcinoma of lung (disorder)	8	CGI;CTD_human
Tgene		C2751681	NEUROBLASTOMA, SUSCEPTIBILITY TO, 3	8	CLINGEN;UNIPROT
Tgene		C0206180	Ki-1+ Anaplastic Large Cell Lymphoma	6	CGI;CTD_human
Tgene		C0334121	Inflammatory Myofibroblastic Tumor	4	CGI;CTD_human;ORPHANET
Tgene		C0018199	Granuloma, Plasma Cell	3	CTD_human
Tgene		C0007621	Neoplastic Cell Transformation	2	CTD_human
Tgene		C0027627	Neoplasm Metastasis	2	CTD_human
Tgene		C0238463	Papillary thyroid carcinoma	2	ORPHANET
Tgene		C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
Tgene		C0006118	Brain Neoplasms	1	CGI;CTD_human
Tgene		C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene		C0007134	Renal Cell Carcinoma	1	CTD_human
Tgene		C0011570	Mental Depression	1	PSYGENET
Tgene		C0011581	Depressive disorder	1	PSYGENET
Tgene		C0027643	Neoplasm Recurrence, Local	1	CTD_human
Tgene		C0036341	Schizophrenia	1	PSYGENET
Tgene		C0079744	Diffuse Large B-Cell Lymphoma	1	CTD_human
Tgene		C0085269	Plasma Cell Granuloma, Pulmonary	1	CTD_human
Tgene		C0153633	Malignant neoplasm of brain	1	CGI;CTD_human
Tgene		C0278601	Inflammatory Breast Carcinoma	1	CTD_human
Tgene		C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	1	CTD_human
Tgene		C0496899	Benign neoplasm of brain, unspecified	1	CTD_human
Tgene		C0678222	Breast Carcinoma	1	CTD_human
Tgene		C0750974	Brain Tumor, Primary	1	CTD_human
Tgene		C0750977	Recurrent Brain Neoplasm	1	CTD_human
Tgene		C0750979	Primary malignant neoplasm of brain	1	CTD_human
Tgene		C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene		C1266042	Chromophobe Renal Cell Carcinoma	1	CTD_human
Tgene		C1266043	Sarcomatoid Renal Cell Carcinoma	1	CTD_human
Tgene		C1266044	Collecting Duct Carcinoma of the Kidney	1	CTD_human
Tgene		C1306837	Papillary Renal Cell Carcinoma	1	CTD_human
Tgene		C1332079	Anaplastic Large Cell Lymphoma, ALK-Positive	1	ORPHANET
Tgene		C1458155	Mammary Neoplasms	1	CTD_human
Tgene		C1527390	Neoplasms, Intracranial	1	CTD_human
Tgene		C2931189	Neural crest tumor	1	ORPHANET
Tgene		C3899155	hereditary neuroblastoma	1	GENOMICS_ENGLAND
Tgene		C4704874	Mammary Carcinoma, Human	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:HIP1-ALK (FusionGDB2 ID:HG3092TG238)

Fusion Gene Summary for HIP1-ALK

Fusion Gene ORF analysis for HIP1-ALK

Fusion Genomic Features for HIP1-ALK

Fusion Protein Features for HIP1-ALK

Fusion Gene Sequence for HIP1-ALK

Fusion Gene PPI Analysis for HIP1-ALK

Related Drugs for HIP1-ALK

Related Diseases for HIP1-ALK

Fusion Gene Studies
in Kim Lab