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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HLA-DRA-PPIG (FusionGDB2 ID:HG3122TG9360)

Fusion Gene Summary for HLA-DRA-PPIG

Fusion gene summary

Fusion gene information	Fusion gene name: HLA-DRA-PPIG
	Fusion gene ID: hg3122tg9360
		Hgene	Tgene
	Gene symbol	HLA-DRA	PPIG
	Gene ID	3122	9360
	Gene name	major histocompatibility complex, class II, DR alpha	peptidylprolyl isomerase G
	Synonyms	HLA-DRA1	CARS-Cyp\|CYP\|SCAF10\|SRCyp
	Cytomap	('HLA-DRA')('PPIG') 6p21.32	2q31.1
	Type of gene	protein-coding	protein-coding
	Description	HLA class II histocompatibility antigen, DR alpha chainMHC class II antigen DRAhistocompatibility antigen HLA-DR alpha	peptidyl-prolyl cis-trans isomerase GCARS-cyclophilinCASP10Clk-associating RS-cyclophilinPPIase GSR-cyclophilinSR-cypSR-related CTD-associated factor 10cyclophilin Gpeptidyl-prolyl isomerase G (cyclophilin G)rotamase G
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000374982, ENST00000395388, ENST00000383127, ENST00000383258, ENST00000383259, ENST00000411505, ENST00000411524, ENST00000414698, ENST00000415767, ENST00000416883, ENST00000418111, ENST00000427753, ENST00000434866, ENST00000442960, ENST00000459705, ENST00000461633, ENST00000481943, ENST00000482781, ENST00000493431, ENST00000498597, ENST00000546379, ENST00000549531, ENST00000551750, ENST00000553193,
Fusion gene scores	* DoF score	6 X 5 X 2=60	4 X 6 X 1=24
	# samples	6	6
	** MAII score	log2(6/60*10)=0	log2(6/24*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: HLA-DRA [Title/Abstract] AND PPIG [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HLA-DRA(32412649)-PPIG(170493305), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HLA-DRA	GO:0002503	peptide antigen assembly with MHC class II protein complex	1448172\|7606781\|22733780
Hgene	HLA-DRA	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	21502329
Tgene	PPIG	GO:0000413	protein peptidyl-prolyl isomerization	20676357

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BE177297	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-

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Fusion Gene ORF analysis for HLA-DRA-PPIG

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000374982	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
3UTR-3CDS	ENST00000374982	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
3UTR-3CDS	ENST00000395388	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
3UTR-3CDS	ENST00000395388	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
3UTR-3UTR	ENST00000374982	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
3UTR-3UTR	ENST00000395388	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
3UTR-intron	ENST00000374982	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
3UTR-intron	ENST00000374982	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
3UTR-intron	ENST00000395388	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
3UTR-intron	ENST00000395388	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000383127	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000383127	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000383258	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000383258	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000383259	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000383259	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000411505	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000411505	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000411524	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000411524	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000414698	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000414698	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000415767	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000415767	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000416883	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000416883	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000418111	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000418111	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000427753	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000427753	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000434866	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000434866	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000442960	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000442960	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000459705	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000459705	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000461633	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000461633	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000481943	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000481943	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000482781	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000482781	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000493431	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000493431	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000498597	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000498597	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000546379	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000546379	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000549531	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000549531	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000551750	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000551750	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000553193	ENST00000260970	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3CDS	ENST00000553193	ENST00000409714	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000383127	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000383258	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000383259	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000411505	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000411524	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000414698	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000415767	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000416883	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000418111	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000427753	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000434866	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000442960	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000459705	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000461633	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000481943	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000482781	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000493431	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000498597	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000546379	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000549531	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000551750	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-3UTR	ENST00000553193	ENST00000482772	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000383127	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000383127	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000383258	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000383258	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000383259	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000383259	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000411505	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000411505	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000411524	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000411524	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000414698	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000414698	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000415767	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000415767	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000416883	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000416883	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000418111	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000418111	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000427753	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000427753	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000434866	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000434866	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000442960	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000442960	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000459705	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000459705	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000461633	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000461633	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000481943	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000481943	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000482781	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000482781	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000493431	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000493431	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000498597	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000498597	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000546379	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000546379	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000549531	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000549531	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000551750	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000551750	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000553193	ENST00000448752	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-
intron-intron	ENST00000553193	ENST00000462903	HLA-DRA	chr6	32412649	+	PPIG	chr2	170493305	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for HLA-DRA-PPIG

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

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Fusion Protein Features for HLA-DRA-PPIG

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:32412649/:170493305)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for HLA-DRA-PPIG

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HLA-DRA-PPIG

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HLA-DRA-PPIG

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HLA-DRA-PPIG

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HLA-DRA	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
Hgene	HLA-DRA	C0026769	Multiple Sclerosis	1	CTD_human
Hgene	HLA-DRA	C0030567	Parkinson Disease	1	CTD_human
Hgene	HLA-DRA	C0036981	Endotoxic shock	1	CTD_human
Hgene	HLA-DRA	C0036983	Septic Shock	1	CTD_human
Hgene	HLA-DRA	C0600327	Toxic Shock Syndrome	1	CTD_human
Hgene	HLA-DRA	C0751324	Multiple Sclerosis, Acute Fulminating	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:HLA-DRA-PPIG (FusionGDB2 ID:HG3122TG9360)

Fusion Gene Summary for HLA-DRA-PPIG

Fusion Gene ORF analysis for HLA-DRA-PPIG

Fusion Genomic Features for HLA-DRA-PPIG

Fusion Protein Features for HLA-DRA-PPIG

Fusion Gene Sequence for HLA-DRA-PPIG

Fusion Gene PPI Analysis for HLA-DRA-PPIG

Related Drugs for HLA-DRA-PPIG

Related Diseases for HLA-DRA-PPIG

Fusion Gene Studies
in Kim Lab