Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:HOXB3-FAP (FusionGDB2 ID:HG3213TG2191)

Fusion Gene Summary for HOXB3-FAP

check button Fusion gene summary
Fusion gene informationFusion gene name: HOXB3-FAP
Fusion gene ID: hg3213tg2191
HgeneTgene
Gene symbol

HOXB3

FAP

Gene ID

3213

2191

Gene namehomeobox B3fibroblast activation protein alpha
SynonymsHOX2|HOX2G|Hox-2.7DPPIV|FAPA|FAPalpha|SIMP
Cytomap('HOXB3')('FAP')

17q21.32

2q24.2

Type of geneprotein-codingprotein-coding
Descriptionhomeobox protein Hox-B3homeo box 2Ghomeobox protein Hox-2.7homeobox protein Hox-2Gprolyl endopeptidase FAP170 kDa melanoma membrane-bound gelatinasedipeptidyl peptidase FAPgelatine degradation protease FAPintegral membrane serine proteasepost-proline cleaving enzymeseprasesurface-expressed protease
Modification date2020031320200313
UniProtAcc.

Q12884

Ensembl transtripts involved in fusion geneENST00000465120, ENST00000490677, 
ENST00000311626, ENST00000460160, 
ENST00000485909, ENST00000489475, 
ENST00000498678, ENST00000470495, 
ENST00000472863, ENST00000476342, 
ENST00000552000, 
Fusion gene scores* DoF score9 X 6 X 6=3243 X 4 X 3=36
# samples 103
** MAII scorelog2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HOXB3 [Title/Abstract] AND FAP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHOXB3(46651199)-FAP(163046264), # samples:1
HOXB3(46651199)-FAP(163044873), # samples:1
Anticipated loss of major functional domain due to fusion event.HOXB3-FAP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HOXB3-FAP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HOXB3-FAP seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
HOXB3-FAP seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHOXB3

GO:0045944

positive regulation of transcription by RNA polymerase II

9556594

TgeneFAP

GO:0006508

proteolysis

10455171

TgeneFAP

GO:0010710

regulation of collagen catabolic process

10455171

TgeneFAP

GO:0010716

negative regulation of extracellular matrix disassembly

16651416

TgeneFAP

GO:0043542

endothelial cell migration

16651416

TgeneFAP

GO:0051603

proteolysis involved in cellular protein catabolic process

10593948

TgeneFAP

GO:1903054

negative regulation of extracellular matrix organization

10455171


check buttonFusion gene breakpoints across HOXB3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FAP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-B5-A5OD-01AHOXB3chr17

46651199

-FAPchr2

163044873

-
ChimerDB4UCECTCGA-B5-A5OD-01AHOXB3chr17

46651199

-FAPchr2

163046264

-


Top

Fusion Gene ORF analysis for HOXB3-FAP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000465120ENST00000493182HOXB3chr17

46651199

-FAPchr2

163044873

-
5CDS-intronENST00000465120ENST00000493182HOXB3chr17

46651199

-FAPchr2

163046264

-
5CDS-intronENST00000490677ENST00000493182HOXB3chr17

46651199

-FAPchr2

163044873

-
5CDS-intronENST00000490677ENST00000493182HOXB3chr17

46651199

-FAPchr2

163046264

-
5UTR-3CDSENST00000311626ENST00000188790HOXB3chr17

46651199

-FAPchr2

163044873

-
5UTR-3CDSENST00000311626ENST00000188790HOXB3chr17

46651199

-FAPchr2

163046264

-
5UTR-3CDSENST00000311626ENST00000443424HOXB3chr17

46651199

-FAPchr2

163044873

-
5UTR-3CDSENST00000311626ENST00000443424HOXB3chr17

46651199

-FAPchr2

163046264

-
5UTR-3CDSENST00000460160ENST00000188790HOXB3chr17

46651199

-FAPchr2

163044873

-
5UTR-3CDSENST00000460160ENST00000188790HOXB3chr17

46651199

-FAPchr2

163046264

-
5UTR-3CDSENST00000460160ENST00000443424HOXB3chr17

46651199

-FAPchr2

163044873

-
5UTR-3CDSENST00000460160ENST00000443424HOXB3chr17

46651199

-FAPchr2

163046264

-
5UTR-3CDSENST00000485909ENST00000188790HOXB3chr17

46651199

-FAPchr2

163044873

-
5UTR-3CDSENST00000485909ENST00000188790HOXB3chr17

46651199

-FAPchr2

163046264

-
5UTR-3CDSENST00000485909ENST00000443424HOXB3chr17

46651199

-FAPchr2

163044873

-
5UTR-3CDSENST00000485909ENST00000443424HOXB3chr17

46651199

-FAPchr2

163046264

-
5UTR-3CDSENST00000489475ENST00000188790HOXB3chr17

46651199

-FAPchr2

163044873

-
5UTR-3CDSENST00000489475ENST00000188790HOXB3chr17

46651199

-FAPchr2

163046264

-
5UTR-3CDSENST00000489475ENST00000443424HOXB3chr17

46651199

-FAPchr2

163044873

-
5UTR-3CDSENST00000489475ENST00000443424HOXB3chr17

46651199

-FAPchr2

163046264

-
5UTR-3CDSENST00000498678ENST00000188790HOXB3chr17

46651199

-FAPchr2

163044873

-
5UTR-3CDSENST00000498678ENST00000188790HOXB3chr17

46651199

-FAPchr2

163046264

-
5UTR-3CDSENST00000498678ENST00000443424HOXB3chr17

46651199

-FAPchr2

163044873

-
5UTR-3CDSENST00000498678ENST00000443424HOXB3chr17

46651199

-FAPchr2

163046264

-
5UTR-intronENST00000311626ENST00000493182HOXB3chr17

46651199

-FAPchr2

163044873

-
5UTR-intronENST00000311626ENST00000493182HOXB3chr17

46651199

-FAPchr2

163046264

-
5UTR-intronENST00000460160ENST00000493182HOXB3chr17

46651199

-FAPchr2

163044873

-
5UTR-intronENST00000460160ENST00000493182HOXB3chr17

46651199

-FAPchr2

163046264

-
5UTR-intronENST00000485909ENST00000493182HOXB3chr17

46651199

-FAPchr2

163044873

-
5UTR-intronENST00000485909ENST00000493182HOXB3chr17

46651199

-FAPchr2

163046264

-
5UTR-intronENST00000489475ENST00000493182HOXB3chr17

46651199

-FAPchr2

163044873

-
5UTR-intronENST00000489475ENST00000493182HOXB3chr17

46651199

-FAPchr2

163046264

-
5UTR-intronENST00000498678ENST00000493182HOXB3chr17

46651199

-FAPchr2

163044873

-
5UTR-intronENST00000498678ENST00000493182HOXB3chr17

46651199

-FAPchr2

163046264

-
Frame-shiftENST00000465120ENST00000188790HOXB3chr17

46651199

-FAPchr2

163046264

-
Frame-shiftENST00000465120ENST00000443424HOXB3chr17

46651199

-FAPchr2

163046264

-
Frame-shiftENST00000490677ENST00000188790HOXB3chr17

46651199

-FAPchr2

163044873

-
Frame-shiftENST00000490677ENST00000188790HOXB3chr17

46651199

-FAPchr2

163046264

-
Frame-shiftENST00000490677ENST00000443424HOXB3chr17

46651199

-FAPchr2

163044873

-
Frame-shiftENST00000490677ENST00000443424HOXB3chr17

46651199

-FAPchr2

163046264

-
In-frameENST00000465120ENST00000188790HOXB3chr17

46651199

-FAPchr2

163044873

-
In-frameENST00000465120ENST00000443424HOXB3chr17

46651199

-FAPchr2

163044873

-
intron-3CDSENST00000470495ENST00000188790HOXB3chr17

46651199

-FAPchr2

163044873

-
intron-3CDSENST00000470495ENST00000188790HOXB3chr17

46651199

-FAPchr2

163046264

-
intron-3CDSENST00000470495ENST00000443424HOXB3chr17

46651199

-FAPchr2

163044873

-
intron-3CDSENST00000470495ENST00000443424HOXB3chr17

46651199

-FAPchr2

163046264

-
intron-3CDSENST00000472863ENST00000188790HOXB3chr17

46651199

-FAPchr2

163044873

-
intron-3CDSENST00000472863ENST00000188790HOXB3chr17

46651199

-FAPchr2

163046264

-
intron-3CDSENST00000472863ENST00000443424HOXB3chr17

46651199

-FAPchr2

163044873

-
intron-3CDSENST00000472863ENST00000443424HOXB3chr17

46651199

-FAPchr2

163046264

-
intron-3CDSENST00000476342ENST00000188790HOXB3chr17

46651199

-FAPchr2

163044873

-
intron-3CDSENST00000476342ENST00000188790HOXB3chr17

46651199

-FAPchr2

163046264

-
intron-3CDSENST00000476342ENST00000443424HOXB3chr17

46651199

-FAPchr2

163044873

-
intron-3CDSENST00000476342ENST00000443424HOXB3chr17

46651199

-FAPchr2

163046264

-
intron-3CDSENST00000552000ENST00000188790HOXB3chr17

46651199

-FAPchr2

163044873

-
intron-3CDSENST00000552000ENST00000188790HOXB3chr17

46651199

-FAPchr2

163046264

-
intron-3CDSENST00000552000ENST00000443424HOXB3chr17

46651199

-FAPchr2

163044873

-
intron-3CDSENST00000552000ENST00000443424HOXB3chr17

46651199

-FAPchr2

163046264

-
intron-intronENST00000470495ENST00000493182HOXB3chr17

46651199

-FAPchr2

163044873

-
intron-intronENST00000470495ENST00000493182HOXB3chr17

46651199

-FAPchr2

163046264

-
intron-intronENST00000472863ENST00000493182HOXB3chr17

46651199

-FAPchr2

163044873

-
intron-intronENST00000472863ENST00000493182HOXB3chr17

46651199

-FAPchr2

163046264

-
intron-intronENST00000476342ENST00000493182HOXB3chr17

46651199

-FAPchr2

163044873

-
intron-intronENST00000476342ENST00000493182HOXB3chr17

46651199

-FAPchr2

163046264

-
intron-intronENST00000552000ENST00000493182HOXB3chr17

46651199

-FAPchr2

163044873

-
intron-intronENST00000552000ENST00000493182HOXB3chr17

46651199

-FAPchr2

163046264

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000465120HOXB3chr1746651199-ENST00000188790FAPchr2163044873-1252299231962243
ENST00000465120HOXB3chr1746651199-ENST00000443424FAPchr2163044873-1224299231962243

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000465120ENST00000188790HOXB3chr1746651199-FAPchr2163044873-0.0007442890.9992557
ENST00000465120ENST00000443424HOXB3chr1746651199-FAPchr2163044873-0.0007659310.9992341

Top

Fusion Genomic Features for HOXB3-FAP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for HOXB3-FAP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:46651199/chr2:163046264)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FAP

Q12884

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:9065413, PubMed:2172980, PubMed:7923219, PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711). Also has dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro (PubMed:10347120, PubMed:10593948, PubMed:16175601, PubMed:16223769, PubMed:16651416, PubMed:16410248, PubMed:17381073, PubMed:21314817, PubMed:24371721, PubMed:24717288). Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB) (PubMed:21314817). The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner. {ECO:0000250|UniProtKB:P97321, ECO:0000269|PubMed:10347120, ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:12376466, ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16175601, ECO:0000269|PubMed:16223769, ECO:0000269|PubMed:16410248, ECO:0000269|PubMed:16480718, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:17105646, ECO:0000269|PubMed:17381073, ECO:0000269|PubMed:18095711, ECO:0000269|PubMed:20707604, ECO:0000269|PubMed:21288888, ECO:0000269|PubMed:21314817, ECO:0000269|PubMed:2172980, ECO:0000269|PubMed:24371721, ECO:0000269|PubMed:24717288, ECO:0000269|PubMed:7923219, ECO:0000269|PubMed:9065413}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHOXB3chr17:46651199chr2:163044873ENST00000311626-14154_1780432.0Compositional biasNote=Gly-rich
HgeneHOXB3chr17:46651199chr2:163044873ENST00000470495-12154_1780432.0Compositional biasNote=Gly-rich
HgeneHOXB3chr17:46651199chr2:163044873ENST00000476342-13154_1780432.0Compositional biasNote=Gly-rich
HgeneHOXB3chr17:46651199chr2:163044873ENST00000498678-25154_1780432.0Compositional biasNote=Gly-rich
HgeneHOXB3chr17:46651199chr2:163044873ENST00000311626-14188_2470432.0DNA bindingHomeobox
HgeneHOXB3chr17:46651199chr2:163044873ENST00000470495-12188_2470432.0DNA bindingHomeobox
HgeneHOXB3chr17:46651199chr2:163044873ENST00000476342-13188_2470432.0DNA bindingHomeobox
HgeneHOXB3chr17:46651199chr2:163044873ENST00000498678-25188_2470432.0DNA bindingHomeobox
HgeneHOXB3chr17:46651199chr2:163044873ENST00000311626-14129_1340432.0MotifNote=Antp-type hexapeptide
HgeneHOXB3chr17:46651199chr2:163044873ENST00000470495-12129_1340432.0MotifNote=Antp-type hexapeptide
HgeneHOXB3chr17:46651199chr2:163044873ENST00000476342-13129_1340432.0MotifNote=Antp-type hexapeptide
HgeneHOXB3chr17:46651199chr2:163044873ENST00000498678-25129_1340432.0MotifNote=Antp-type hexapeptide
TgeneFAPchr17:46651199chr2:163044873ENST0000018879018261_4539761.0Topological domainCytoplasmic
TgeneFAPchr17:46651199chr2:163044873ENST00000188790182626_760539761.0Topological domainExtracellular
TgeneFAPchr17:46651199chr2:163044873ENST0000018879018265_25539761.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


Top

Fusion Gene Sequence for HOXB3-FAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37427_37427_1_HOXB3-FAP_HOXB3_chr17_46651199_ENST00000465120_FAP_chr2_163044873_ENST00000188790_length(transcript)=1252nt_BP=299nt
CAAAGGGATGTGAGATTTCTATTCGCCGCGGAGGCGGCGACAATTAGAACGTCTCGGACCCATGGCGGGGCGGCCATTGGCTCGGAGGAT
CACGTGGGCGCCTAACTTTGTTCACTTGACACAAATCTCCTTGGACCGGCTGTTGGGGGAAAAAAGTGTTAGCCGTCTCTCCCGGATCTG
CAAGGGGGAAAAAATTTGGAACCATAAAGTTGAAAACTTTTTTCTCTCAGTTTGGAAGAAGCCCTTCGTCATGAATGGGATCTGCAGAGT
TCGGGCGAGAGGAGGCGAGAGGCGCAAAGGTATGGTGGTCCCTGCAGTCAGAGTGTAAGGTCTGTATTTGCTGTTAATTGGATATCTTAT
CTTGCAAGTAAGGAAGGGATGGTCATTGCCTTGGTGGATGGTCGAGGAACAGCTTTCCAAGGTGACAAACTCCTCTATGCAGTGTATCGA
AAGCTGGGTGTTTATGAAGTTGAAGACCAGATTACAGCTGTCAGAAAATTCATAGAAATGGGTTTCATTGATGAAAAAAGAATAGCCATA
TGGGGCTGGTCCTATGGAGGATACGTTTCATCACTGGCCCTTGCATCTGGAACTGGTCTTTTCAAATGTGGTATAGCAGTGGCTCCAGTC
TCCAGCTGGGAATATTACGCGTCTGTCTACACAGAGAGATTCATGGGTCTCCCAACAAAGGATGATAATCTTGAGCACTATAAGAATTCA
ACTGTGATGGCAAGAGCAGAATATTTCAGAAATGTAGACTATCTTCTCATCCACGGAACAGCAGATGATAATGTGCACTTTCAAAACTCA
GCACAGATTGCTAAAGCTCTGGTTAATGCACAAGTGGATTTCCAGGCAATGTGGTACTCTGACCAGAACCACGGCTTATCCGGCCTGTCC
ACGAACCACTTATACACCCACATGACCCACTTCCTAAAGCAGTGTTTCTCTTTGTCAGACTAAAAACGATGCAGATGCAAGCCTGTATCA
GAATCTGAAAACCTTATATAAACCCCTCAGACAGTTTGCTTATTTTATTTTTTATGTTGTAAAATGCTAGTATAAACAAACAAATTAATG
TTGTTCTAAAGGCTGTTAAAAAAAAGATGAGGACTCAGAAGTTCAAGCTAAATATTGTTTACATTTTCTGGTACTCTGTGAAAGAAGAGA

>37427_37427_1_HOXB3-FAP_HOXB3_chr17_46651199_ENST00000465120_FAP_chr2_163044873_ENST00000188790_length(amino acids)=243AA_BP=22
MEEALRHEWDLQSSGERRREAQRYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKF
IEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLI

--------------------------------------------------------------
>37427_37427_2_HOXB3-FAP_HOXB3_chr17_46651199_ENST00000465120_FAP_chr2_163044873_ENST00000443424_length(transcript)=1224nt_BP=299nt
CAAAGGGATGTGAGATTTCTATTCGCCGCGGAGGCGGCGACAATTAGAACGTCTCGGACCCATGGCGGGGCGGCCATTGGCTCGGAGGAT
CACGTGGGCGCCTAACTTTGTTCACTTGACACAAATCTCCTTGGACCGGCTGTTGGGGGAAAAAAGTGTTAGCCGTCTCTCCCGGATCTG
CAAGGGGGAAAAAATTTGGAACCATAAAGTTGAAAACTTTTTTCTCTCAGTTTGGAAGAAGCCCTTCGTCATGAATGGGATCTGCAGAGT
TCGGGCGAGAGGAGGCGAGAGGCGCAAAGGTATGGTGGTCCCTGCAGTCAGAGTGTAAGGTCTGTATTTGCTGTTAATTGGATATCTTAT
CTTGCAAGTAAGGAAGGGATGGTCATTGCCTTGGTGGATGGTCGAGGAACAGCTTTCCAAGGTGACAAACTCCTCTATGCAGTGTATCGA
AAGCTGGGTGTTTATGAAGTTGAAGACCAGATTACAGCTGTCAGAAAATTCATAGAAATGGGTTTCATTGATGAAAAAAGAATAGCCATA
TGGGGCTGGTCCTATGGAGGATACGTTTCATCACTGGCCCTTGCATCTGGAACTGGTCTTTTCAAATGTGGTATAGCAGTGGCTCCAGTC
TCCAGCTGGGAATATTACGCGTCTGTCTACACAGAGAGATTCATGGGTCTCCCAACAAAGGATGATAATCTTGAGCACTATAAGAATTCA
ACTGTGATGGCAAGAGCAGAATATTTCAGAAATGTAGACTATCTTCTCATCCACGGAACAGCAGATGATAATGTGCACTTTCAAAACTCA
GCACAGATTGCTAAAGCTCTGGTTAATGCACAAGTGGATTTCCAGGCAATGTGGTACTCTGACCAGAACCACGGCTTATCCGGCCTGTCC
ACGAACCACTTATACACCCACATGACCCACTTCCTAAAGCAGTGTTTCTCTTTGTCAGACTAAAAACGATGCAGATGCAAGCCTGTATCA
GAATCTGAAAACCTTATATAAACCCCTCAGACAGTTTGCTTATTTTATTTTTTATGTTGTAAAATGCTAGTATAAACAAACAAATTAATG
TTGTTCTAAAGGCTGTTAAAAAAAAGATGAGGACTCAGAAGTTCAAGCTAAATATTGTTTACATTTTCTGGTACTCTGTGAAAGAAGAGA

>37427_37427_2_HOXB3-FAP_HOXB3_chr17_46651199_ENST00000465120_FAP_chr2_163044873_ENST00000443424_length(amino acids)=243AA_BP=22
MEEALRHEWDLQSSGERRREAQRYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKF
IEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for HOXB3-FAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for HOXB3-FAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for HOXB3-FAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHOXB3C0019284Diaphragmatic Hernia1CTD_human