Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:HPRT1-CTPS2 (FusionGDB2 ID:HG3251TG56474)

Fusion Gene Summary for HPRT1-CTPS2

check button Fusion gene summary
Fusion gene informationFusion gene name: HPRT1-CTPS2
Fusion gene ID: hg3251tg56474
HgeneTgene
Gene symbol

HPRT1

CTPS2

Gene ID

3251

56474

Gene namehypoxanthine phosphoribosyltransferase 1CTP synthase 2
SynonymsHGPRT|HPRT-
Cytomap('HPRT1')('CTPS2')

Xq26.2-q26.3

Xp22.2

Type of geneprotein-codingprotein-coding
Descriptionhypoxanthine-guanine phosphoribosyltransferaseHGPRTasehypoxanthine-guanine phosphoribosyltransferase 1testicular tissue protein Li 89CTP synthase 2CTP synthase IICTP synthetase type 2UTP-ammonia ligase 2cytidine 5'-triphosphate synthetase 2
Modification date2020031320200313
UniProtAcc.

Q9NRF8

Ensembl transtripts involved in fusion geneENST00000462974, ENST00000298556, 
Fusion gene scores* DoF score3 X 4 X 3=369 X 9 X 3=243
# samples 39
** MAII scorelog2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/243*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HPRT1 [Title/Abstract] AND CTPS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHPRT1(133609394)-CTPS2(16657366), # samples:4
Anticipated loss of major functional domain due to fusion event.HPRT1-CTPS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HPRT1-CTPS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHPRT1

GO:0006178

guanine salvage

19527031

HgeneHPRT1

GO:0043103

hypoxanthine salvage

19527031

HgeneHPRT1

GO:0046038

GMP catabolic process

19527031

HgeneHPRT1

GO:0046040

IMP metabolic process

19527031


check buttonFusion gene breakpoints across HPRT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CTPS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A24W-01AHPRT1chrX

133609393

+CTPS2chrX

16657365

-
ChimerDB4BRCATCGA-AR-A24W-01AHPRT1chrX

133609394

-CTPS2chrX

16657366

-
ChimerDB4BRCATCGA-AR-A24W-01AHPRT1chrX

133609394

+CTPS2chrX

16657366

-
ChimerDB4BRCATCGA-AR-A24WHPRT1chrX

133609394

+CTPS2chrX

16657366

-


Top

Fusion Gene ORF analysis for HPRT1-CTPS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000462974ENST00000359276HPRT1chrX

133609393

+CTPS2chrX

16657365

-
3UTR-3CDSENST00000462974ENST00000359276HPRT1chrX

133609394

+CTPS2chrX

16657366

-
3UTR-3CDSENST00000462974ENST00000380241HPRT1chrX

133609393

+CTPS2chrX

16657365

-
3UTR-3CDSENST00000462974ENST00000380241HPRT1chrX

133609394

+CTPS2chrX

16657366

-
3UTR-3CDSENST00000462974ENST00000443824HPRT1chrX

133609393

+CTPS2chrX

16657365

-
3UTR-3CDSENST00000462974ENST00000443824HPRT1chrX

133609394

+CTPS2chrX

16657366

-
3UTR-intronENST00000462974ENST00000483053HPRT1chrX

133609393

+CTPS2chrX

16657365

-
3UTR-intronENST00000462974ENST00000483053HPRT1chrX

133609394

+CTPS2chrX

16657366

-
5CDS-intronENST00000298556ENST00000483053HPRT1chrX

133609393

+CTPS2chrX

16657365

-
5CDS-intronENST00000298556ENST00000483053HPRT1chrX

133609394

+CTPS2chrX

16657366

-
In-frameENST00000298556ENST00000359276HPRT1chrX

133609393

+CTPS2chrX

16657365

-
In-frameENST00000298556ENST00000359276HPRT1chrX

133609394

+CTPS2chrX

16657366

-
In-frameENST00000298556ENST00000380241HPRT1chrX

133609393

+CTPS2chrX

16657365

-
In-frameENST00000298556ENST00000380241HPRT1chrX

133609394

+CTPS2chrX

16657366

-
In-frameENST00000298556ENST00000443824HPRT1chrX

133609393

+CTPS2chrX

16657365

-
In-frameENST00000298556ENST00000443824HPRT1chrX

133609394

+CTPS2chrX

16657366

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000298556HPRT1chrX133609394+ENST00000443824CTPS2chrX16657366-27564770941313
ENST00000298556HPRT1chrX133609394+ENST00000359276CTPS2chrX16657366-24534770941313
ENST00000298556HPRT1chrX133609394+ENST00000380241CTPS2chrX16657366-24534770941313
ENST00000298556HPRT1chrX133609393+ENST00000443824CTPS2chrX16657365-27564770941313
ENST00000298556HPRT1chrX133609393+ENST00000359276CTPS2chrX16657365-24534770941313
ENST00000298556HPRT1chrX133609393+ENST00000380241CTPS2chrX16657365-24534770941313

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000298556ENST00000443824HPRT1chrX133609394+CTPS2chrX16657366-0.0019675590.9980324
ENST00000298556ENST00000359276HPRT1chrX133609394+CTPS2chrX16657366-0.0019541120.9980459
ENST00000298556ENST00000380241HPRT1chrX133609394+CTPS2chrX16657366-0.0019541120.9980459
ENST00000298556ENST00000443824HPRT1chrX133609393+CTPS2chrX16657365-0.0019675590.9980324
ENST00000298556ENST00000359276HPRT1chrX133609393+CTPS2chrX16657365-0.0019541120.9980459
ENST00000298556ENST00000380241HPRT1chrX133609393+CTPS2chrX16657365-0.0019541120.9980459

Top

Fusion Genomic Features for HPRT1-CTPS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for HPRT1-CTPS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:133609394/chrX:16657366)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CTPS2

Q9NRF8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. {ECO:0000269|PubMed:10899599, ECO:0000269|PubMed:16179339}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHPRT1chrX:133609393chrX:16657365ENST00000298556+39134_142106219.0Nucleotide bindingGMP
HgeneHPRT1chrX:133609393chrX:16657365ENST00000298556+39186_188106219.0Nucleotide bindingGMP
HgeneHPRT1chrX:133609394chrX:16657366ENST00000298556+39134_142106219.0Nucleotide bindingGMP
HgeneHPRT1chrX:133609394chrX:16657366ENST00000298556+39186_188106219.0Nucleotide bindingGMP
TgeneCTPS2chrX:133609393chrX:16657365ENST000003592761219300_554432939.6666666666666DomainGlutamine amidotransferase type-1
TgeneCTPS2chrX:133609393chrX:16657365ENST000003802411219300_554432974.0DomainGlutamine amidotransferase type-1
TgeneCTPS2chrX:133609393chrX:16657365ENST000004438241219300_554432911.6666666666666DomainGlutamine amidotransferase type-1
TgeneCTPS2chrX:133609394chrX:16657366ENST000003592761219300_554432939.6666666666666DomainGlutamine amidotransferase type-1
TgeneCTPS2chrX:133609394chrX:16657366ENST000003802411219300_554432974.0DomainGlutamine amidotransferase type-1
TgeneCTPS2chrX:133609394chrX:16657366ENST000004438241219300_554432911.6666666666666DomainGlutamine amidotransferase type-1


Top

Fusion Gene Sequence for HPRT1-CTPS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37519_37519_1_HPRT1-CTPS2_HPRT1_chrX_133609393_ENST00000298556_CTPS2_chrX_16657365_ENST00000359276_length(transcript)=2453nt_BP=477nt
CTGCTTCTCCTCAGCTTCAGGCGGCTGCGACGAGCCCTCAGGCGAACCTCTCGGCTTTCCCGCGCGGCGCCGCCTCTTGCTGCGCCTCCG
CCTCCTCCTCTGCTCCGCCACCGGCTTCCTCCTCCTGAGCAGTCAGCCCGCGCGCCGGCCGGCTCCGTTATGGCGACCCGCAGCCCTGGC
GTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGATTTATTTTGCATACCTAATCATTATGCTGAGGATTTGGAAAGGGTGTTTATT
CCTCATGGACTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCATCACATTGTAGCCCTCTGTGTG
CTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGATTACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACTGTA
GATTTTATCAGACTGAAGAGCTATTGTGTGATTGATATGCCCGAGCACAACCCTGGCAATTTGGGAGGAACAATGAGACTGGGAATAAGA
AGAACTGTTTTCAAAACTGAAAATTCAATATTAAGGAAACTTTATGGTGATGTTCCTTTTATAGAAGAAAGACACAGACATCGGTTCGAG
GTAAACCCTAACCTGATCAAACAATTTGAGCAGAATGACTTAAGTTTTGTAGGTCAGGATGTTGATGGAGACAGGATGGAAATCATTGAA
CTGGCAAATCATCCTTATTTTGTTGGTGTCCAGTTCCATCCTGAGTTTTCTTCTAGGCCGATGAAGCCTTCCCCTCCGTATCTGGGGCTG
TTACTTGCAGCAACTGGGAACCTGAATGCCTACTTGCAACAGGGTTGCAAACTGTCTTCCAGTGATAGATACAGTGATGCCAGTGATGAC
AGCTTTTCAGAGCCAAGGATAGCTGAGTTGGAAATAAGCTGAAATGAATACATGACTGGGAATAATGGGGACTGCCTGTGAGGCCTCTGA
AATAATTGAAGGCAAGATGAAGGAACTATCTGAAGAAATCACTACACTCTTAGAGAATCCCTCTGTTCTCCAGCAAACATGGGATGTAAA
GCCTCACAGGGAATCTGATAATACATACTTCTGTCAACCAGAACCAGAGGGGTAGTTTTCTTTTCCCTCCAGAGGCAGCCTTTGGTACTT
AAAATATCTGTAGCTGATTAAATTTTTCCCAACAACCTCACTGGGGAGAAAGTGTGTTCATGTTTTGTCCAGCGGATCAGGATGTTAGGA
TGACGAGCAAGAGTCCAGGTCACTGTGCCTTTGCTGTGTTGTATGGAAAGGATGGCAGGGAACATGCTGTAAGTAATTTTGAGTAAGAAA
ATGAGTCACTGTGTTACCTGGAACTCAGCCACAGATTTGTGTGTGGTCCAAGATCATTGCAGTTTCTCACCCTGTTTATTTCCTGGTAAA
AGTAAAATTGAATAGGTCCAAGACTTGGGGGTGGCAAGTAAGGCTTTGCCTCAGGCACAAAATTTAAGGGGGCTCCAAAAAACTCAGGAA
TCAAGATCAGCAATACAGTCTGAGTATCCCTTATGTGAAATGCTTGGGGCTAGAAGTGTTTTGAATTTCAGATTTTGGAATATTTGCATA
TACATGCGATATCTTGGGGATGAGACTCAAGACTAAACATGAAATTCATTTATGCTTCATATACACCTTATATACATAGCCTAAAGGTAA
TTTGATACAATATTTTAAATAATTTTGTGCATGAAACAAAGTTTCGACTGCATTTTGACTGTGATTTCTGGCATGAGATCAGTTATGGAA
TTTTCCACTTCTAGCGTCATGTTGGCATTCAGAAATTTTGAAATTTTGGAGCATTTTGGATTTTCAGATTAGGGATGCTCAACCTGTATA
TATATTTTTTAATCGACGTGAAATTCACGTAACATAGAATTAACCATTTTGAAGTGAACAATTTGGTTGCATTCACTGATGTTGAGCAAC
CACCACCTTTAACTATTTCCAAAACATTTTCATCACTCCAAAATAAATGCCTGTACACACTAGCAGTCACTCCCTATCTTCCCCTCCACC
TGTCCGCTGGCAACCACTGATCTCCTTTTTATTTCTGTGGCTTTTTCTATTCTGGATATTTCATATAAGTGGAATTACACAATATATGTG
GTCTTTTGTGTCTGGCTTCTTCTGAGACAGTAGGAAGGGGGGCTTGGCTTTGGCTCACCCCCACTAGAGCATTTTTTCATGCATTCCCAC
TGATCACAAAACCCATACTACTACCTCATTGACACCATACCTGCTAACCTCGAGGCTTTAGTCATACAAAGAAAATGGCCTTTCTGTATT
GTTCTTCTGTGCTCTCATAATGCTTAACCATGTCTTTTACTTAAACAATTCCAGGAACTGGCCTTAGGAGATCCAAATAGGGAACCAAGA

>37519_37519_1_HPRT1-CTPS2_HPRT1_chrX_133609393_ENST00000298556_CTPS2_chrX_16657365_ENST00000359276_length(amino acids)=313AA_BP=159
LLLLSFRRLRRALRRTSRLSRAAPPLAAPPPPPLLRHRLPPPEQSARAPAGSVMATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFI
PHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCVIDMPEHNPGNLGGTMRLGIR
RTVFKTENSILRKLYGDVPFIEERHRHRFEVNPNLIKQFEQNDLSFVGQDVDGDRMEIIELANHPYFVGVQFHPEFSSRPMKPSPPYLGL

--------------------------------------------------------------
>37519_37519_2_HPRT1-CTPS2_HPRT1_chrX_133609393_ENST00000298556_CTPS2_chrX_16657365_ENST00000380241_length(transcript)=2453nt_BP=477nt
CTGCTTCTCCTCAGCTTCAGGCGGCTGCGACGAGCCCTCAGGCGAACCTCTCGGCTTTCCCGCGCGGCGCCGCCTCTTGCTGCGCCTCCG
CCTCCTCCTCTGCTCCGCCACCGGCTTCCTCCTCCTGAGCAGTCAGCCCGCGCGCCGGCCGGCTCCGTTATGGCGACCCGCAGCCCTGGC
GTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGATTTATTTTGCATACCTAATCATTATGCTGAGGATTTGGAAAGGGTGTTTATT
CCTCATGGACTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCATCACATTGTAGCCCTCTGTGTG
CTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGATTACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACTGTA
GATTTTATCAGACTGAAGAGCTATTGTGTGATTGATATGCCCGAGCACAACCCTGGCAATTTGGGAGGAACAATGAGACTGGGAATAAGA
AGAACTGTTTTCAAAACTGAAAATTCAATATTAAGGAAACTTTATGGTGATGTTCCTTTTATAGAAGAAAGACACAGACATCGGTTCGAG
GTAAACCCTAACCTGATCAAACAATTTGAGCAGAATGACTTAAGTTTTGTAGGTCAGGATGTTGATGGAGACAGGATGGAAATCATTGAA
CTGGCAAATCATCCTTATTTTGTTGGTGTCCAGTTCCATCCTGAGTTTTCTTCTAGGCCGATGAAGCCTTCCCCTCCGTATCTGGGGCTG
TTACTTGCAGCAACTGGGAACCTGAATGCCTACTTGCAACAGGGTTGCAAACTGTCTTCCAGTGATAGATACAGTGATGCCAGTGATGAC
AGCTTTTCAGAGCCAAGGATAGCTGAGTTGGAAATAAGCTGAAATGAATACATGACTGGGAATAATGGGGACTGCCTGTGAGGCCTCTGA
AATAATTGAAGGCAAGATGAAGGAACTATCTGAAGAAATCACTACACTCTTAGAGAATCCCTCTGTTCTCCAGCAAACATGGGATGTAAA
GCCTCACAGGGAATCTGATAATACATACTTCTGTCAACCAGAACCAGAGGGGTAGTTTTCTTTTCCCTCCAGAGGCAGCCTTTGGTACTT
AAAATATCTGTAGCTGATTAAATTTTTCCCAACAACCTCACTGGGGAGAAAGTGTGTTCATGTTTTGTCCAGCGGATCAGGATGTTAGGA
TGACGAGCAAGAGTCCAGGTCACTGTGCCTTTGCTGTGTTGTATGGAAAGGATGGCAGGGAACATGCTGTAAGTAATTTTGAGTAAGAAA
ATGAGTCACTGTGTTACCTGGAACTCAGCCACAGATTTGTGTGTGGTCCAAGATCATTGCAGTTTCTCACCCTGTTTATTTCCTGGTAAA
AGTAAAATTGAATAGGTCCAAGACTTGGGGGTGGCAAGTAAGGCTTTGCCTCAGGCACAAAATTTAAGGGGGCTCCAAAAAACTCAGGAA
TCAAGATCAGCAATACAGTCTGAGTATCCCTTATGTGAAATGCTTGGGGCTAGAAGTGTTTTGAATTTCAGATTTTGGAATATTTGCATA
TACATGCGATATCTTGGGGATGAGACTCAAGACTAAACATGAAATTCATTTATGCTTCATATACACCTTATATACATAGCCTAAAGGTAA
TTTGATACAATATTTTAAATAATTTTGTGCATGAAACAAAGTTTCGACTGCATTTTGACTGTGATTTCTGGCATGAGATCAGTTATGGAA
TTTTCCACTTCTAGCGTCATGTTGGCATTCAGAAATTTTGAAATTTTGGAGCATTTTGGATTTTCAGATTAGGGATGCTCAACCTGTATA
TATATTTTTTAATCGACGTGAAATTCACGTAACATAGAATTAACCATTTTGAAGTGAACAATTTGGTTGCATTCACTGATGTTGAGCAAC
CACCACCTTTAACTATTTCCAAAACATTTTCATCACTCCAAAATAAATGCCTGTACACACTAGCAGTCACTCCCTATCTTCCCCTCCACC
TGTCCGCTGGCAACCACTGATCTCCTTTTTATTTCTGTGGCTTTTTCTATTCTGGATATTTCATATAAGTGGAATTACACAATATATGTG
GTCTTTTGTGTCTGGCTTCTTCTGAGACAGTAGGAAGGGGGGCTTGGCTTTGGCTCACCCCCACTAGAGCATTTTTTCATGCATTCCCAC
TGATCACAAAACCCATACTACTACCTCATTGACACCATACCTGCTAACCTCGAGGCTTTAGTCATACAAAGAAAATGGCCTTTCTGTATT
GTTCTTCTGTGCTCTCATAATGCTTAACCATGTCTTTTACTTAAACAATTCCAGGAACTGGCCTTAGGAGATCCAAATAGGGAACCAAGA

>37519_37519_2_HPRT1-CTPS2_HPRT1_chrX_133609393_ENST00000298556_CTPS2_chrX_16657365_ENST00000380241_length(amino acids)=313AA_BP=159
LLLLSFRRLRRALRRTSRLSRAAPPLAAPPPPPLLRHRLPPPEQSARAPAGSVMATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFI
PHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCVIDMPEHNPGNLGGTMRLGIR
RTVFKTENSILRKLYGDVPFIEERHRHRFEVNPNLIKQFEQNDLSFVGQDVDGDRMEIIELANHPYFVGVQFHPEFSSRPMKPSPPYLGL

--------------------------------------------------------------
>37519_37519_3_HPRT1-CTPS2_HPRT1_chrX_133609393_ENST00000298556_CTPS2_chrX_16657365_ENST00000443824_length(transcript)=2756nt_BP=477nt
CTGCTTCTCCTCAGCTTCAGGCGGCTGCGACGAGCCCTCAGGCGAACCTCTCGGCTTTCCCGCGCGGCGCCGCCTCTTGCTGCGCCTCCG
CCTCCTCCTCTGCTCCGCCACCGGCTTCCTCCTCCTGAGCAGTCAGCCCGCGCGCCGGCCGGCTCCGTTATGGCGACCCGCAGCCCTGGC
GTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGATTTATTTTGCATACCTAATCATTATGCTGAGGATTTGGAAAGGGTGTTTATT
CCTCATGGACTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCATCACATTGTAGCCCTCTGTGTG
CTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGATTACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACTGTA
GATTTTATCAGACTGAAGAGCTATTGTGTGATTGATATGCCCGAGCACAACCCTGGCAATTTGGGAGGAACAATGAGACTGGGAATAAGA
AGAACTGTTTTCAAAACTGAAAATTCAATATTAAGGAAACTTTATGGTGATGTTCCTTTTATAGAAGAAAGACACAGACATCGGTTCGAG
GTAAACCCTAACCTGATCAAACAATTTGAGCAGAATGACTTAAGTTTTGTAGGTCAGGATGTTGATGGAGACAGGATGGAAATCATTGAA
CTGGCAAATCATCCTTATTTTGTTGGTGTCCAGTTCCATCCTGAGTTTTCTTCTAGGCCGATGAAGCCTTCCCCTCCGTATCTGGGGCTG
TTACTTGCAGCAACTGGGAACCTGAATGCCTACTTGCAACAGGGTTGCAAACTGTCTTCCAGTGATAGATACAGTGATGCCAGTGATGAC
AGCTTTTCAGAGCCAAGGATAGCTGAGTTGGAAATAAGCTGAAATGAATACATGACTGGGAATAATGGGGACTGCCTGTGAGGCCTCTGA
AATAATTGAAGGCAAGATGAAGGAACTATCTGAAGAAATCACTACACTCTTAGAGAATCCCTCTGTTCTCCAGCAAACATGGGATGTAAA
GCCTCACAGGGAATCTGATAATACATACTTCTGTCAACCAGAACCAGAGGGGTAGTTTTCTTTTCCCTCCAGAGGCAGCCTTTGGTACTT
AAAATATCTGTAGCTGATTAAATTTTTCCCAACAACCTCACTGGGGAGAAAGTGTGTTCATGTTTTGTCCAGCGGATCAGGATGTTAGGA
TGACGAGCAAGAGTCCAGGTCACTGTGCCTTTGCTGTGTTGTATGGAAAGGATGGCAGGGAACATGCTGTAAGTAATTTTGAGTAAGAAA
ATGAGTCACTGTGTTACCTGGAACTCAGCCACAGATTTGTGTGTGGTCCAAGATCATTGCAGTTTCTCACCCTGTTTATTTCCTGGTAAA
AGTAAAATTGAATAGGTCCAAGACTTGGGGGTGGCAAGTAAGGCTTTGCCTCAGGCACAAAATTTAAGGGGGCTCCAAAAAACTCAGGAA
TCAAGATCAGCAATACAGTCTGAGTATCCCTTATGTGAAATGCTTGGGGCTAGAAGTGTTTTGAATTTCAGATTTTGGAATATTTGCATA
TACATGCGATATCTTGGGGATGAGACTCAAGACTAAACATGAAATTCATTTATGCTTCATATACACCTTATATACATAGCCTAAAGGTAA
TTTGATACAATATTTTAAATAATTTTGTGCATGAAACAAAGTTTCGACTGCATTTTGACTGTGATTTCTGGCATGAGATCAGTTATGGAA
TTTTCCACTTCTAGCGTCATGTTGGCATTCAGAAATTTTGAAATTTTGGAGCATTTTGGATTTTCAGATTAGGGATGCTCAACCTGTATA
TATATTTTTTAATCGACGTGAAATTCACGTAACATAGAATTAACCATTTTGAAGTGAACAATTTGGTTGCATTCACTGATGTTGAGCAAC
CACCACCTTTAACTATTTCCAAAACATTTTCATCACTCCAAAATAAATGCCTGTACACACTAGCAGTCACTCCCTATCTTCCCCTCCACC
TGTCCGCTGGCAACCACTGATCTCCTTTTTATTTCTGTGGCTTTTTCTATTCTGGATATTTCATATAAGTGGAATTACACAATATATGTG
GTCTTTTGTGTCTGGCTTCTTCTGAGACAGTAGGAAGGGGGGCTTGGCTTTGGCTCACCCCCACTAGAGCATTTTTTCATGCATTCCCAC
TGATCACAAAACCCATACTACTACCTCATTGACACCATACCTGCTAACCTCGAGGCTTTAGTCATACAAAGAAAATGGCCTTTCTGTATT
GTTCTTCTGTGCTCTCATAATGCTTAACCATGTCTTTTACTTAAACAATTCCAGGAACTGGCCTTAGGAGATCCAAATAGGGAACCAAGA
TTGCAGAGTGTCCCATCTTGGGAGGGAATGCTGAATAATTAATTGATTTACAGCCTTGTTGCCGCTGGCCAGACCACCAGGTGGCCCATT
ACTCGAGATGATCATCACAACCAGATGATGCTAACCTATATCCTCTACCCTTCGCGTGCTTTGTCTGGGAAGTCTTTTGGCCCCATGTCA
GTTTCTATTGCATTGAGAGCCCAAGAGCCCCTGGTCAGTCAGGCTTCCATTTAGCATGGCGTTTGCAAGGTTTACCCATGTTGTAGCATG

>37519_37519_3_HPRT1-CTPS2_HPRT1_chrX_133609393_ENST00000298556_CTPS2_chrX_16657365_ENST00000443824_length(amino acids)=313AA_BP=159
LLLLSFRRLRRALRRTSRLSRAAPPLAAPPPPPLLRHRLPPPEQSARAPAGSVMATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFI
PHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCVIDMPEHNPGNLGGTMRLGIR
RTVFKTENSILRKLYGDVPFIEERHRHRFEVNPNLIKQFEQNDLSFVGQDVDGDRMEIIELANHPYFVGVQFHPEFSSRPMKPSPPYLGL

--------------------------------------------------------------
>37519_37519_4_HPRT1-CTPS2_HPRT1_chrX_133609394_ENST00000298556_CTPS2_chrX_16657366_ENST00000359276_length(transcript)=2453nt_BP=477nt
CTGCTTCTCCTCAGCTTCAGGCGGCTGCGACGAGCCCTCAGGCGAACCTCTCGGCTTTCCCGCGCGGCGCCGCCTCTTGCTGCGCCTCCG
CCTCCTCCTCTGCTCCGCCACCGGCTTCCTCCTCCTGAGCAGTCAGCCCGCGCGCCGGCCGGCTCCGTTATGGCGACCCGCAGCCCTGGC
GTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGATTTATTTTGCATACCTAATCATTATGCTGAGGATTTGGAAAGGGTGTTTATT
CCTCATGGACTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCATCACATTGTAGCCCTCTGTGTG
CTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGATTACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACTGTA
GATTTTATCAGACTGAAGAGCTATTGTGTGATTGATATGCCCGAGCACAACCCTGGCAATTTGGGAGGAACAATGAGACTGGGAATAAGA
AGAACTGTTTTCAAAACTGAAAATTCAATATTAAGGAAACTTTATGGTGATGTTCCTTTTATAGAAGAAAGACACAGACATCGGTTCGAG
GTAAACCCTAACCTGATCAAACAATTTGAGCAGAATGACTTAAGTTTTGTAGGTCAGGATGTTGATGGAGACAGGATGGAAATCATTGAA
CTGGCAAATCATCCTTATTTTGTTGGTGTCCAGTTCCATCCTGAGTTTTCTTCTAGGCCGATGAAGCCTTCCCCTCCGTATCTGGGGCTG
TTACTTGCAGCAACTGGGAACCTGAATGCCTACTTGCAACAGGGTTGCAAACTGTCTTCCAGTGATAGATACAGTGATGCCAGTGATGAC
AGCTTTTCAGAGCCAAGGATAGCTGAGTTGGAAATAAGCTGAAATGAATACATGACTGGGAATAATGGGGACTGCCTGTGAGGCCTCTGA
AATAATTGAAGGCAAGATGAAGGAACTATCTGAAGAAATCACTACACTCTTAGAGAATCCCTCTGTTCTCCAGCAAACATGGGATGTAAA
GCCTCACAGGGAATCTGATAATACATACTTCTGTCAACCAGAACCAGAGGGGTAGTTTTCTTTTCCCTCCAGAGGCAGCCTTTGGTACTT
AAAATATCTGTAGCTGATTAAATTTTTCCCAACAACCTCACTGGGGAGAAAGTGTGTTCATGTTTTGTCCAGCGGATCAGGATGTTAGGA
TGACGAGCAAGAGTCCAGGTCACTGTGCCTTTGCTGTGTTGTATGGAAAGGATGGCAGGGAACATGCTGTAAGTAATTTTGAGTAAGAAA
ATGAGTCACTGTGTTACCTGGAACTCAGCCACAGATTTGTGTGTGGTCCAAGATCATTGCAGTTTCTCACCCTGTTTATTTCCTGGTAAA
AGTAAAATTGAATAGGTCCAAGACTTGGGGGTGGCAAGTAAGGCTTTGCCTCAGGCACAAAATTTAAGGGGGCTCCAAAAAACTCAGGAA
TCAAGATCAGCAATACAGTCTGAGTATCCCTTATGTGAAATGCTTGGGGCTAGAAGTGTTTTGAATTTCAGATTTTGGAATATTTGCATA
TACATGCGATATCTTGGGGATGAGACTCAAGACTAAACATGAAATTCATTTATGCTTCATATACACCTTATATACATAGCCTAAAGGTAA
TTTGATACAATATTTTAAATAATTTTGTGCATGAAACAAAGTTTCGACTGCATTTTGACTGTGATTTCTGGCATGAGATCAGTTATGGAA
TTTTCCACTTCTAGCGTCATGTTGGCATTCAGAAATTTTGAAATTTTGGAGCATTTTGGATTTTCAGATTAGGGATGCTCAACCTGTATA
TATATTTTTTAATCGACGTGAAATTCACGTAACATAGAATTAACCATTTTGAAGTGAACAATTTGGTTGCATTCACTGATGTTGAGCAAC
CACCACCTTTAACTATTTCCAAAACATTTTCATCACTCCAAAATAAATGCCTGTACACACTAGCAGTCACTCCCTATCTTCCCCTCCACC
TGTCCGCTGGCAACCACTGATCTCCTTTTTATTTCTGTGGCTTTTTCTATTCTGGATATTTCATATAAGTGGAATTACACAATATATGTG
GTCTTTTGTGTCTGGCTTCTTCTGAGACAGTAGGAAGGGGGGCTTGGCTTTGGCTCACCCCCACTAGAGCATTTTTTCATGCATTCCCAC
TGATCACAAAACCCATACTACTACCTCATTGACACCATACCTGCTAACCTCGAGGCTTTAGTCATACAAAGAAAATGGCCTTTCTGTATT
GTTCTTCTGTGCTCTCATAATGCTTAACCATGTCTTTTACTTAAACAATTCCAGGAACTGGCCTTAGGAGATCCAAATAGGGAACCAAGA

>37519_37519_4_HPRT1-CTPS2_HPRT1_chrX_133609394_ENST00000298556_CTPS2_chrX_16657366_ENST00000359276_length(amino acids)=313AA_BP=159
LLLLSFRRLRRALRRTSRLSRAAPPLAAPPPPPLLRHRLPPPEQSARAPAGSVMATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFI
PHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCVIDMPEHNPGNLGGTMRLGIR
RTVFKTENSILRKLYGDVPFIEERHRHRFEVNPNLIKQFEQNDLSFVGQDVDGDRMEIIELANHPYFVGVQFHPEFSSRPMKPSPPYLGL

--------------------------------------------------------------
>37519_37519_5_HPRT1-CTPS2_HPRT1_chrX_133609394_ENST00000298556_CTPS2_chrX_16657366_ENST00000380241_length(transcript)=2453nt_BP=477nt
CTGCTTCTCCTCAGCTTCAGGCGGCTGCGACGAGCCCTCAGGCGAACCTCTCGGCTTTCCCGCGCGGCGCCGCCTCTTGCTGCGCCTCCG
CCTCCTCCTCTGCTCCGCCACCGGCTTCCTCCTCCTGAGCAGTCAGCCCGCGCGCCGGCCGGCTCCGTTATGGCGACCCGCAGCCCTGGC
GTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGATTTATTTTGCATACCTAATCATTATGCTGAGGATTTGGAAAGGGTGTTTATT
CCTCATGGACTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCATCACATTGTAGCCCTCTGTGTG
CTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGATTACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACTGTA
GATTTTATCAGACTGAAGAGCTATTGTGTGATTGATATGCCCGAGCACAACCCTGGCAATTTGGGAGGAACAATGAGACTGGGAATAAGA
AGAACTGTTTTCAAAACTGAAAATTCAATATTAAGGAAACTTTATGGTGATGTTCCTTTTATAGAAGAAAGACACAGACATCGGTTCGAG
GTAAACCCTAACCTGATCAAACAATTTGAGCAGAATGACTTAAGTTTTGTAGGTCAGGATGTTGATGGAGACAGGATGGAAATCATTGAA
CTGGCAAATCATCCTTATTTTGTTGGTGTCCAGTTCCATCCTGAGTTTTCTTCTAGGCCGATGAAGCCTTCCCCTCCGTATCTGGGGCTG
TTACTTGCAGCAACTGGGAACCTGAATGCCTACTTGCAACAGGGTTGCAAACTGTCTTCCAGTGATAGATACAGTGATGCCAGTGATGAC
AGCTTTTCAGAGCCAAGGATAGCTGAGTTGGAAATAAGCTGAAATGAATACATGACTGGGAATAATGGGGACTGCCTGTGAGGCCTCTGA
AATAATTGAAGGCAAGATGAAGGAACTATCTGAAGAAATCACTACACTCTTAGAGAATCCCTCTGTTCTCCAGCAAACATGGGATGTAAA
GCCTCACAGGGAATCTGATAATACATACTTCTGTCAACCAGAACCAGAGGGGTAGTTTTCTTTTCCCTCCAGAGGCAGCCTTTGGTACTT
AAAATATCTGTAGCTGATTAAATTTTTCCCAACAACCTCACTGGGGAGAAAGTGTGTTCATGTTTTGTCCAGCGGATCAGGATGTTAGGA
TGACGAGCAAGAGTCCAGGTCACTGTGCCTTTGCTGTGTTGTATGGAAAGGATGGCAGGGAACATGCTGTAAGTAATTTTGAGTAAGAAA
ATGAGTCACTGTGTTACCTGGAACTCAGCCACAGATTTGTGTGTGGTCCAAGATCATTGCAGTTTCTCACCCTGTTTATTTCCTGGTAAA
AGTAAAATTGAATAGGTCCAAGACTTGGGGGTGGCAAGTAAGGCTTTGCCTCAGGCACAAAATTTAAGGGGGCTCCAAAAAACTCAGGAA
TCAAGATCAGCAATACAGTCTGAGTATCCCTTATGTGAAATGCTTGGGGCTAGAAGTGTTTTGAATTTCAGATTTTGGAATATTTGCATA
TACATGCGATATCTTGGGGATGAGACTCAAGACTAAACATGAAATTCATTTATGCTTCATATACACCTTATATACATAGCCTAAAGGTAA
TTTGATACAATATTTTAAATAATTTTGTGCATGAAACAAAGTTTCGACTGCATTTTGACTGTGATTTCTGGCATGAGATCAGTTATGGAA
TTTTCCACTTCTAGCGTCATGTTGGCATTCAGAAATTTTGAAATTTTGGAGCATTTTGGATTTTCAGATTAGGGATGCTCAACCTGTATA
TATATTTTTTAATCGACGTGAAATTCACGTAACATAGAATTAACCATTTTGAAGTGAACAATTTGGTTGCATTCACTGATGTTGAGCAAC
CACCACCTTTAACTATTTCCAAAACATTTTCATCACTCCAAAATAAATGCCTGTACACACTAGCAGTCACTCCCTATCTTCCCCTCCACC
TGTCCGCTGGCAACCACTGATCTCCTTTTTATTTCTGTGGCTTTTTCTATTCTGGATATTTCATATAAGTGGAATTACACAATATATGTG
GTCTTTTGTGTCTGGCTTCTTCTGAGACAGTAGGAAGGGGGGCTTGGCTTTGGCTCACCCCCACTAGAGCATTTTTTCATGCATTCCCAC
TGATCACAAAACCCATACTACTACCTCATTGACACCATACCTGCTAACCTCGAGGCTTTAGTCATACAAAGAAAATGGCCTTTCTGTATT
GTTCTTCTGTGCTCTCATAATGCTTAACCATGTCTTTTACTTAAACAATTCCAGGAACTGGCCTTAGGAGATCCAAATAGGGAACCAAGA

>37519_37519_5_HPRT1-CTPS2_HPRT1_chrX_133609394_ENST00000298556_CTPS2_chrX_16657366_ENST00000380241_length(amino acids)=313AA_BP=159
LLLLSFRRLRRALRRTSRLSRAAPPLAAPPPPPLLRHRLPPPEQSARAPAGSVMATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFI
PHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCVIDMPEHNPGNLGGTMRLGIR
RTVFKTENSILRKLYGDVPFIEERHRHRFEVNPNLIKQFEQNDLSFVGQDVDGDRMEIIELANHPYFVGVQFHPEFSSRPMKPSPPYLGL

--------------------------------------------------------------
>37519_37519_6_HPRT1-CTPS2_HPRT1_chrX_133609394_ENST00000298556_CTPS2_chrX_16657366_ENST00000443824_length(transcript)=2756nt_BP=477nt
CTGCTTCTCCTCAGCTTCAGGCGGCTGCGACGAGCCCTCAGGCGAACCTCTCGGCTTTCCCGCGCGGCGCCGCCTCTTGCTGCGCCTCCG
CCTCCTCCTCTGCTCCGCCACCGGCTTCCTCCTCCTGAGCAGTCAGCCCGCGCGCCGGCCGGCTCCGTTATGGCGACCCGCAGCCCTGGC
GTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGATTTATTTTGCATACCTAATCATTATGCTGAGGATTTGGAAAGGGTGTTTATT
CCTCATGGACTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCATCACATTGTAGCCCTCTGTGTG
CTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGATTACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACTGTA
GATTTTATCAGACTGAAGAGCTATTGTGTGATTGATATGCCCGAGCACAACCCTGGCAATTTGGGAGGAACAATGAGACTGGGAATAAGA
AGAACTGTTTTCAAAACTGAAAATTCAATATTAAGGAAACTTTATGGTGATGTTCCTTTTATAGAAGAAAGACACAGACATCGGTTCGAG
GTAAACCCTAACCTGATCAAACAATTTGAGCAGAATGACTTAAGTTTTGTAGGTCAGGATGTTGATGGAGACAGGATGGAAATCATTGAA
CTGGCAAATCATCCTTATTTTGTTGGTGTCCAGTTCCATCCTGAGTTTTCTTCTAGGCCGATGAAGCCTTCCCCTCCGTATCTGGGGCTG
TTACTTGCAGCAACTGGGAACCTGAATGCCTACTTGCAACAGGGTTGCAAACTGTCTTCCAGTGATAGATACAGTGATGCCAGTGATGAC
AGCTTTTCAGAGCCAAGGATAGCTGAGTTGGAAATAAGCTGAAATGAATACATGACTGGGAATAATGGGGACTGCCTGTGAGGCCTCTGA
AATAATTGAAGGCAAGATGAAGGAACTATCTGAAGAAATCACTACACTCTTAGAGAATCCCTCTGTTCTCCAGCAAACATGGGATGTAAA
GCCTCACAGGGAATCTGATAATACATACTTCTGTCAACCAGAACCAGAGGGGTAGTTTTCTTTTCCCTCCAGAGGCAGCCTTTGGTACTT
AAAATATCTGTAGCTGATTAAATTTTTCCCAACAACCTCACTGGGGAGAAAGTGTGTTCATGTTTTGTCCAGCGGATCAGGATGTTAGGA
TGACGAGCAAGAGTCCAGGTCACTGTGCCTTTGCTGTGTTGTATGGAAAGGATGGCAGGGAACATGCTGTAAGTAATTTTGAGTAAGAAA
ATGAGTCACTGTGTTACCTGGAACTCAGCCACAGATTTGTGTGTGGTCCAAGATCATTGCAGTTTCTCACCCTGTTTATTTCCTGGTAAA
AGTAAAATTGAATAGGTCCAAGACTTGGGGGTGGCAAGTAAGGCTTTGCCTCAGGCACAAAATTTAAGGGGGCTCCAAAAAACTCAGGAA
TCAAGATCAGCAATACAGTCTGAGTATCCCTTATGTGAAATGCTTGGGGCTAGAAGTGTTTTGAATTTCAGATTTTGGAATATTTGCATA
TACATGCGATATCTTGGGGATGAGACTCAAGACTAAACATGAAATTCATTTATGCTTCATATACACCTTATATACATAGCCTAAAGGTAA
TTTGATACAATATTTTAAATAATTTTGTGCATGAAACAAAGTTTCGACTGCATTTTGACTGTGATTTCTGGCATGAGATCAGTTATGGAA
TTTTCCACTTCTAGCGTCATGTTGGCATTCAGAAATTTTGAAATTTTGGAGCATTTTGGATTTTCAGATTAGGGATGCTCAACCTGTATA
TATATTTTTTAATCGACGTGAAATTCACGTAACATAGAATTAACCATTTTGAAGTGAACAATTTGGTTGCATTCACTGATGTTGAGCAAC
CACCACCTTTAACTATTTCCAAAACATTTTCATCACTCCAAAATAAATGCCTGTACACACTAGCAGTCACTCCCTATCTTCCCCTCCACC
TGTCCGCTGGCAACCACTGATCTCCTTTTTATTTCTGTGGCTTTTTCTATTCTGGATATTTCATATAAGTGGAATTACACAATATATGTG
GTCTTTTGTGTCTGGCTTCTTCTGAGACAGTAGGAAGGGGGGCTTGGCTTTGGCTCACCCCCACTAGAGCATTTTTTCATGCATTCCCAC
TGATCACAAAACCCATACTACTACCTCATTGACACCATACCTGCTAACCTCGAGGCTTTAGTCATACAAAGAAAATGGCCTTTCTGTATT
GTTCTTCTGTGCTCTCATAATGCTTAACCATGTCTTTTACTTAAACAATTCCAGGAACTGGCCTTAGGAGATCCAAATAGGGAACCAAGA
TTGCAGAGTGTCCCATCTTGGGAGGGAATGCTGAATAATTAATTGATTTACAGCCTTGTTGCCGCTGGCCAGACCACCAGGTGGCCCATT
ACTCGAGATGATCATCACAACCAGATGATGCTAACCTATATCCTCTACCCTTCGCGTGCTTTGTCTGGGAAGTCTTTTGGCCCCATGTCA
GTTTCTATTGCATTGAGAGCCCAAGAGCCCCTGGTCAGTCAGGCTTCCATTTAGCATGGCGTTTGCAAGGTTTACCCATGTTGTAGCATG

>37519_37519_6_HPRT1-CTPS2_HPRT1_chrX_133609394_ENST00000298556_CTPS2_chrX_16657366_ENST00000443824_length(amino acids)=313AA_BP=159
LLLLSFRRLRRALRRTSRLSRAAPPLAAPPPPPLLRHRLPPPEQSARAPAGSVMATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFI
PHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCVIDMPEHNPGNLGGTMRLGIR
RTVFKTENSILRKLYGDVPFIEERHRHRFEVNPNLIKQFEQNDLSFVGQDVDGDRMEIIELANHPYFVGVQFHPEFSSRPMKPSPPYLGL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for HPRT1-CTPS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for HPRT1-CTPS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for HPRT1-CTPS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHPRT1C0023374Lesch-Nyhan Syndrome24CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneHPRT1C0268117Gout, HPRT-Related16CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneHPRT1C0013421Dystonia1GENOMICS_ENGLAND
HgeneHPRT1C0740394Hyperuricemia1CTD_human
HgeneHPRT1C1959897Alcohol consumption during pregnancy1PSYGENET