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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:APOB-CLU (FusionGDB2 ID:HG338TG1191) |
Fusion Gene Summary for APOB-CLU |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: APOB-CLU | Fusion gene ID: hg338tg1191 | Hgene | Tgene | Gene symbol | APOB | CLU | Gene ID | 338 | 1191 |
| Gene name | apolipoprotein B | clusterin | |
| Synonyms | FCHL2|FLDB|LDLCQ4|apoB-100|apoB-48 | AAG4|APO-J|APOJ|CLI|CLU1|CLU2|KUB1|NA1/NA2|SGP-2|SGP2|SP-40|TRPM-2|TRPM2 | |
| Cytomap | ('APOB')('CLU') 2p24.1 | 8p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | apolipoprotein B-100apolipoprotein B (including Ag(x) antigen)apolipoprotein B48 | clusterinaging-associated protein 4apolipoprotein Jcomplement cytolysis inhibitorcomplement lysis inhibitorcomplement-associated protein SP-40,40epididymis secretory sperm binding proteinku70-binding protein 1sulfated glycoprotein 2testosterone-r | |
| Modification date | 20200327 | 20200327 | |
| UniProtAcc | P04114 | P10909 | |
| Ensembl transtripts involved in fusion gene | ENST00000233242, ENST00000399256, | ||
| Fusion gene scores | * DoF score | 7 X 9 X 4=252 | 23 X 24 X 12=6624 |
| # samples | 9 | 30 | |
| ** MAII score | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(30/6624*10)=-4.46466826700344 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: APOB [Title/Abstract] AND CLU [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | APOB(21252511)-CLU(27456152), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | APOB-CLU seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. APOB-CLU seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. APOB-CLU seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. APOB-CLU seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | APOB | GO:0010744 | positive regulation of macrophage derived foam cell differentiation | 17244792|18322245|19114110 |
| Hgene | APOB | GO:0010884 | positive regulation of lipid storage | 18322245 |
| Hgene | APOB | GO:0010886 | positive regulation of cholesterol storage | 19114110 |
| Tgene | CLU | GO:0000902 | cell morphogenesis | 15857407 |
| Tgene | CLU | GO:0001774 | microglial cell activation | 15857407 |
| Tgene | CLU | GO:0017038 | protein import | 24446231 |
| Tgene | CLU | GO:0031333 | negative regulation of protein complex assembly | 22179788|23106396 |
| Tgene | CLU | GO:0031334 | positive regulation of protein complex assembly | 22179788 |
| Tgene | CLU | GO:0032760 | positive regulation of tumor necrosis factor production | 15857407 |
| Tgene | CLU | GO:0045429 | positive regulation of nitric oxide biosynthetic process | 15857407 |
| Tgene | CLU | GO:0050821 | protein stabilization | 11123922|12176985 |
| Tgene | CLU | GO:0051131 | chaperone-mediated protein complex assembly | 17412999 |
| Tgene | CLU | GO:0051788 | response to misfolded protein | 19996109 |
| Tgene | CLU | GO:0061077 | chaperone-mediated protein folding | 11123922 |
| Tgene | CLU | GO:0061518 | microglial cell proliferation | 15857407 |
| Tgene | CLU | GO:1900221 | regulation of amyloid-beta clearance | 24446231 |
| Tgene | CLU | GO:1901214 | regulation of neuron death | 17412999 |
| Tgene | CLU | GO:1901216 | positive regulation of neuron death | 15857407 |
| Tgene | CLU | GO:1902430 | negative regulation of amyloid-beta formation | 12047389|17412999 |
| Tgene | CLU | GO:1905907 | negative regulation of amyloid fibril formation | 22179788 |
| Fusion gene breakpoints across APOB (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CLU (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LIHC | TCGA-DD-A1EH-01A | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - |
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Fusion Gene ORF analysis for APOB-CLU |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000233242 | ENST00000316403 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - |
| In-frame | ENST00000233242 | ENST00000405140 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - |
| In-frame | ENST00000233242 | ENST00000523500 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - |
| In-frame | ENST00000233242 | ENST00000546343 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - |
| In-frame | ENST00000233242 | ENST00000560366 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - |
| In-frame | ENST00000399256 | ENST00000316403 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - |
| In-frame | ENST00000399256 | ENST00000405140 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - |
| In-frame | ENST00000399256 | ENST00000523500 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - |
| In-frame | ENST00000399256 | ENST00000546343 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - |
| In-frame | ENST00000399256 | ENST00000560366 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000233242 | APOB | chr2 | 21252511 | - | ENST00000316403 | CLU | chr8 | 27456152 | - | 3255 | 1745 | 122 | 1930 | 602 |
| ENST00000233242 | APOB | chr2 | 21252511 | - | ENST00000546343 | CLU | chr8 | 27456152 | - | 3237 | 1745 | 122 | 1930 | 602 |
| ENST00000233242 | APOB | chr2 | 21252511 | - | ENST00000560366 | CLU | chr8 | 27456152 | - | 3237 | 1745 | 122 | 1930 | 602 |
| ENST00000233242 | APOB | chr2 | 21252511 | - | ENST00000405140 | CLU | chr8 | 27456152 | - | 2364 | 1745 | 122 | 1930 | 602 |
| ENST00000233242 | APOB | chr2 | 21252511 | - | ENST00000523500 | CLU | chr8 | 27456152 | - | 2176 | 1745 | 122 | 1930 | 602 |
| ENST00000399256 | APOB | chr2 | 21252511 | - | ENST00000316403 | CLU | chr8 | 27456152 | - | 3144 | 1634 | 11 | 1819 | 602 |
| ENST00000399256 | APOB | chr2 | 21252511 | - | ENST00000546343 | CLU | chr8 | 27456152 | - | 3126 | 1634 | 11 | 1819 | 602 |
| ENST00000399256 | APOB | chr2 | 21252511 | - | ENST00000560366 | CLU | chr8 | 27456152 | - | 3126 | 1634 | 11 | 1819 | 602 |
| ENST00000399256 | APOB | chr2 | 21252511 | - | ENST00000405140 | CLU | chr8 | 27456152 | - | 2253 | 1634 | 11 | 1819 | 602 |
| ENST00000399256 | APOB | chr2 | 21252511 | - | ENST00000523500 | CLU | chr8 | 27456152 | - | 2065 | 1634 | 11 | 1819 | 602 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000233242 | ENST00000316403 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - | 0.001952505 | 0.9980475 |
| ENST00000233242 | ENST00000546343 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - | 0.00206495 | 0.99793506 |
| ENST00000233242 | ENST00000560366 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - | 0.00206495 | 0.99793506 |
| ENST00000233242 | ENST00000405140 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - | 0.006448698 | 0.99355125 |
| ENST00000233242 | ENST00000523500 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - | 0.009076417 | 0.9909236 |
| ENST00000399256 | ENST00000316403 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - | 0.001746974 | 0.99825305 |
| ENST00000399256 | ENST00000546343 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - | 0.001845457 | 0.9981546 |
| ENST00000399256 | ENST00000560366 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - | 0.001845457 | 0.9981546 |
| ENST00000399256 | ENST00000405140 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - | 0.005979851 | 0.9940202 |
| ENST00000399256 | ENST00000523500 | APOB | chr2 | 21252511 | - | CLU | chr8 | 27456152 | - | 0.008274778 | 0.9917252 |
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Fusion Genomic Features for APOB-CLU |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for APOB-CLU |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:21252511/chr8:27456152) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| APOB | CLU |
| FUNCTION: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | FUNCTION: [Isoform 1]: Functions as extracellular chaperone that prevents aggregation of non native proteins (PubMed:11123922, PubMed:19535339). Prevents stress-induced aggregation of blood plasma proteins (PubMed:11123922, PubMed:12176985, PubMed:17260971, PubMed:19996109). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) (PubMed:12047389, PubMed:17412999, PubMed:17407782). Does not require ATP (PubMed:11123922). Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70 (PubMed:11123922). Does not refold proteins by itself (PubMed:11123922). Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation (PubMed:21505792). Protects cells against apoptosis and against cytolysis by complement (PubMed:2780565). Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20068069). Promotes proteasomal degradation of COMMD1 and IKBKB (PubMed:20068069). Modulates NF-kappa-B transcriptional activity (PubMed:12882985). A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis (PubMed:16113678, PubMed:17689225). Plays a role in the regulation of cell proliferation (PubMed:19137541). An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5 (PubMed:22689054). Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed:24073260). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity). {ECO:0000250|UniProtKB:P05371, ECO:0000250|UniProtKB:Q06890, ECO:0000269|PubMed:11123922, ECO:0000269|PubMed:12047389, ECO:0000269|PubMed:12176985, ECO:0000269|PubMed:12882985, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:17260971, ECO:0000269|PubMed:17407782, ECO:0000269|PubMed:17412999, ECO:0000269|PubMed:17689225, ECO:0000269|PubMed:19137541, ECO:0000269|PubMed:19535339, ECO:0000269|PubMed:19996109, ECO:0000269|PubMed:20068069, ECO:0000269|PubMed:21505792, ECO:0000269|PubMed:22689054, ECO:0000269|PubMed:24073260, ECO:0000269|PubMed:2780565}.; FUNCTION: [Isoform 6]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. {ECO:0000269|PubMed:24073260}.; FUNCTION: [Isoform 4]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed:24073260). Promotes cell death through interaction with BCL2L1 that releases and activates BAX (PubMed:21567405). {ECO:0000269|PubMed:21567405, ECO:0000269|PubMed:24073260}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | APOB | chr2:21252511 | chr8:27456152 | ENST00000233242 | - | 12 | 29 | 232_306 | 539 | 4564.0 | Region | Note=Heparin-binding |
| Hgene | APOB | chr2:21252511 | chr8:27456152 | ENST00000233242 | - | 12 | 29 | 32_126 | 539 | 4564.0 | Region | Note=Heparin-binding |
| Tgene | CLU | chr2:21252511 | chr8:27456152 | ENST00000316403 | 6 | 9 | 443_447 | 388 | 450.0 | Motif | Nuclear localization signal | |
| Tgene | CLU | chr2:21252511 | chr8:27456152 | ENST00000405140 | 6 | 9 | 443_447 | 388 | 450.0 | Motif | Nuclear localization signal | |
| Tgene | CLU | chr2:21252511 | chr8:27456152 | ENST00000523500 | 5 | 8 | 443_447 | 388 | 450.0 | Motif | Nuclear localization signal | |
| Tgene | CLU | chr2:21252511 | chr8:27456152 | ENST00000546343 | 6 | 9 | 443_447 | 399 | 461.0 | Motif | Nuclear localization signal | |
| Tgene | CLU | chr2:21252511 | chr8:27456152 | ENST00000560366 | 6 | 9 | 443_447 | 440 | 502.0 | Motif | Nuclear localization signal |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | APOB | chr2:21252511 | chr8:27456152 | ENST00000233242 | - | 12 | 29 | 46_672 | 539 | 4564.0 | Domain | Vitellogenin |
| Hgene | APOB | chr2:21252511 | chr8:27456152 | ENST00000233242 | - | 12 | 29 | 2043_2178 | 539 | 4564.0 | Region | Note=Heparin-binding |
| Hgene | APOB | chr2:21252511 | chr8:27456152 | ENST00000233242 | - | 12 | 29 | 3161_3236 | 539 | 4564.0 | Region | Note=Heparin-binding |
| Hgene | APOB | chr2:21252511 | chr8:27456152 | ENST00000233242 | - | 12 | 29 | 3174_3184 | 539 | 4564.0 | Region | Note=Basic (possible receptor binding region) |
| Hgene | APOB | chr2:21252511 | chr8:27456152 | ENST00000233242 | - | 12 | 29 | 3373_3393 | 539 | 4564.0 | Region | Note=LDL receptor binding |
| Hgene | APOB | chr2:21252511 | chr8:27456152 | ENST00000233242 | - | 12 | 29 | 3383_3516 | 539 | 4564.0 | Region | Note=Heparin-binding |
| Hgene | APOB | chr2:21252511 | chr8:27456152 | ENST00000233242 | - | 12 | 29 | 3386_3394 | 539 | 4564.0 | Region | Note=Basic (possible receptor binding region) |
| Hgene | APOB | chr2:21252511 | chr8:27456152 | ENST00000233242 | - | 12 | 29 | 902_959 | 539 | 4564.0 | Region | Note=Heparin-binding |
| Tgene | CLU | chr2:21252511 | chr8:27456152 | ENST00000316403 | 6 | 9 | 78_81 | 388 | 450.0 | Motif | Nuclear localization signal | |
| Tgene | CLU | chr2:21252511 | chr8:27456152 | ENST00000405140 | 6 | 9 | 78_81 | 388 | 450.0 | Motif | Nuclear localization signal | |
| Tgene | CLU | chr2:21252511 | chr8:27456152 | ENST00000523500 | 5 | 8 | 78_81 | 388 | 450.0 | Motif | Nuclear localization signal | |
| Tgene | CLU | chr2:21252511 | chr8:27456152 | ENST00000546343 | 6 | 9 | 78_81 | 399 | 461.0 | Motif | Nuclear localization signal | |
| Tgene | CLU | chr2:21252511 | chr8:27456152 | ENST00000560366 | 6 | 9 | 78_81 | 440 | 502.0 | Motif | Nuclear localization signal |
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Fusion Gene Sequence for APOB-CLU |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >5530_5530_1_APOB-CLU_APOB_chr2_21252511_ENST00000233242_CLU_chr8_27456152_ENST00000316403_length(transcript)=3255nt_BP=1745nt ATTCCCACCGGGACCTGCGGGGCTGAGTGCCCTTCTCGGTTGCTGCCGCTGAGGAGCCCGCCCAGCCAGCCAGGGCCGCGAGGCCGAGGC CAGGCCGCAGCCCAGGAGCCGCCCCACCGCAGCTGGCGATGGACCCGCCGAGGCCCGCGCTGCTGGCGCTGCTGGCGCTGCCTGCGCTGC TGCTGCTGCTGCTGGCGGGCGCCAGGGCCGAAGAGGAAATGCTGGAAAATGTCAGCCTGGTCTGTCCAAAAGATGCGACCCGATTCAAGC ACCTCCGGAAGTACACATACAACTATGAGGCTGAGAGTTCCAGTGGAGTCCCTGGGACTGCTGATTCAAGAAGTGCCACCAGGATCAACT GCAAGGTTGAGCTGGAGGTTCCCCAGCTCTGCAGCTTCATCCTGAAGACCAGCCAGTGCACCCTGAAAGAGGTGTATGGCTTCAACCCTG AGGGCAAAGCCTTGCTGAAGAAAACCAAGAACTCTGAGGAGTTTGCTGCAGCCATGTCCAGGTATGAGCTCAAGCTGGCCATTCCAGAAG GGAAGCAGGTTTTCCTTTACCCGGAGAAAGATGAACCTACTTACATCCTGAACATCAAGAGGGGCATCATTTCTGCCCTCCTGGTTCCCC CAGAGACAGAAGAAGCCAAGCAAGTGTTGTTTCTGGATACCGTGTATGGAAACTGCTCCACTCACTTTACCGTCAAGACGAGGAAGGGCA ATGTGGCAACAGAAATATCCACTGAAAGAGACCTGGGGCAGTGTGATCGCTTCAAGCCCATCCGCACAGGCATCAGCCCACTTGCTCTCA TCAAAGGCATGACCCGCCCCTTGTCAACTCTGATCAGCAGCAGCCAGTCCTGTCAGTACACACTGGACGCTAAGAGGAAGCATGTGGCAG AAGCCATCTGCAAGGAGCAACACCTCTTCCTGCCTTTCTCCTACAAGAATAAGTATGGGATGGTAGCACAAGTGACACAGACTTTGAAAC TTGAAGACACACCAAAGATCAACAGCCGCTTCTTTGGTGAAGGTACTAAGAAGATGGGCCTCGCATTTGAGAGCACCAAATCCACATCAC CTCCAAAGCAGGCCGAAGCTGTTTTGAAGACTCTCCAGGAACTGAAAAAACTAACCATCTCTGAGCAAAATATCCAGAGAGCTAATCTCT TCAATAAGCTGGTTACTGAGCTGAGAGGCCTCAGTGATGAAGCAGTCACATCTCTCTTGCCACAGCTGATTGAGGTGTCCAGCCCCATCA CTTTACAAGCCTTGGTTCAGTGTGGACAGCCTCAGTGCTCCACTCACATCCTCCAGTGGCTGAAACGTGTGCATGCCAACCCCCTTCTGA TAGATGTGGTCACCTACCTGGTGGCCCTGATCCCCGAGCCCTCAGCACAGCAGCTGCGAGAGATCTTCAACATGGCGAGGGATCAGCGCA GCCGAGCCACCTTGTATGCGCTGAGCCACGCGGTCAACAACTATCATAAGACAAACCCTACAGGGACCCAGGAGCTGCTGGACATTGCTA ATTACCTGATGGAACAGATTCAAGATGACTGCACTGGGGATGAAGATTACACCTATTTGATTCTGCGGGTCATTGGAAATATGGGCCAAA CCATGGAGCAGTTAACTCCAGAACTCAAGTCTTCAATCCTGAAATGTGTCCAAAGTACAAAGCCATCACTGATGATCCAGAAAGCTGCCA TCCAGGCTCTGCGGAAAATGGAGCCTAAAGACAAGGTGGCTTCCCACACTTCTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCG TGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAAGTCTCCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGA AAGCGCTGCAGGAATACCGCAAAAAGCACCGGGAGGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCC CCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCT CTCCCCGCTCTGGATCCTGCACTCTAACACTCGACTCTGCTGCTCATGGGAAGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAA CTGTCTTGTGAGCTGATCGCTTGGAGGGTCCTCTTTTTATGTTGAGTTGCTGCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGC AGGGGGGATGGAAAATAAGTAGAAACAAAAAAGCAGTGGCTAAGATGGTATAGGGACTGTCATACCAGTGAAGAATAAAAGGGTGAAGAA TAAAAGGGATATGATGACAAGGTTGATCCACTTCAAGAATTGCTTGCTTTCAGGAAGAGAGATGTGTTTCAACAAGCCAACTAAAATATA TTGCTGCAAATGGAAGCTTTTCTGTTCTATTATAAAACTGTCGATGTATTCTGACCAAGGTGCGACAATCTCCTAAAGGAATACACTGAA AGTTAAGGAGAAGAATCAGTAAGTGTAAGGTGTACTTGGTATTATAATGCATAATTGATGTTTTCGTTATGAAAACATTTGGTGCCCAGA AGTCCAAATTATCAGTTTTATTTGTAAGAGCTATTGCTTTTGCAGCGGTTTTATTTGTAAAAGCTGTTGATTTCGAGTTGTAAGAGCTCA GCATCCCAGGGGCATCTTCTTGACTGTGGCATTTCCTGTCCACCGCCGGTTTATATGATCTTCATACCTTTCCCTGGACCACAGGCGTTT CTCGGCTTTTAGTCTGAACCATAGCTGGGCTGCAGTACCCTACGCTGCCAGCAGGTGGCCATGACTACCCGTGGTACCAATCTCAGTCTT AAAGCTCAGGCTTTTCGTTCATTAACATTCTCTGATAGAATTCTGGTCATCAGATGTACTGCAATGGAACAAAACTCATCTGGCTGCATC CCAGGTGTGTAGCAAAGTCCACATGTAAATTTATAGCTTAGAATATTCTTAAGTCACTGTCCCTTGTCTCTCTTTGAAGTTATAAACAAC AAACTTAAAGCTTAGCTTATGTCCAAGGTAAGTATTTTAGCATGGCTGTCAAGGAAATTCAGAGTAAAGTCAGTGTGATTCACTTAATGA TATACATTAATTAGAATTATGGGGTCAGAGGTATTTGCTTAAGTGATCATAATTGTAAAGTATATGTCACATTGTCACATTAATGTCACA >5530_5530_1_APOB-CLU_APOB_chr2_21252511_ENST00000233242_CLU_chr8_27456152_ENST00000316403_length(amino acids)=602AA_BP=541 MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD -------------------------------------------------------------- >5530_5530_2_APOB-CLU_APOB_chr2_21252511_ENST00000233242_CLU_chr8_27456152_ENST00000405140_length(transcript)=2364nt_BP=1745nt ATTCCCACCGGGACCTGCGGGGCTGAGTGCCCTTCTCGGTTGCTGCCGCTGAGGAGCCCGCCCAGCCAGCCAGGGCCGCGAGGCCGAGGC CAGGCCGCAGCCCAGGAGCCGCCCCACCGCAGCTGGCGATGGACCCGCCGAGGCCCGCGCTGCTGGCGCTGCTGGCGCTGCCTGCGCTGC TGCTGCTGCTGCTGGCGGGCGCCAGGGCCGAAGAGGAAATGCTGGAAAATGTCAGCCTGGTCTGTCCAAAAGATGCGACCCGATTCAAGC ACCTCCGGAAGTACACATACAACTATGAGGCTGAGAGTTCCAGTGGAGTCCCTGGGACTGCTGATTCAAGAAGTGCCACCAGGATCAACT GCAAGGTTGAGCTGGAGGTTCCCCAGCTCTGCAGCTTCATCCTGAAGACCAGCCAGTGCACCCTGAAAGAGGTGTATGGCTTCAACCCTG AGGGCAAAGCCTTGCTGAAGAAAACCAAGAACTCTGAGGAGTTTGCTGCAGCCATGTCCAGGTATGAGCTCAAGCTGGCCATTCCAGAAG GGAAGCAGGTTTTCCTTTACCCGGAGAAAGATGAACCTACTTACATCCTGAACATCAAGAGGGGCATCATTTCTGCCCTCCTGGTTCCCC CAGAGACAGAAGAAGCCAAGCAAGTGTTGTTTCTGGATACCGTGTATGGAAACTGCTCCACTCACTTTACCGTCAAGACGAGGAAGGGCA ATGTGGCAACAGAAATATCCACTGAAAGAGACCTGGGGCAGTGTGATCGCTTCAAGCCCATCCGCACAGGCATCAGCCCACTTGCTCTCA TCAAAGGCATGACCCGCCCCTTGTCAACTCTGATCAGCAGCAGCCAGTCCTGTCAGTACACACTGGACGCTAAGAGGAAGCATGTGGCAG AAGCCATCTGCAAGGAGCAACACCTCTTCCTGCCTTTCTCCTACAAGAATAAGTATGGGATGGTAGCACAAGTGACACAGACTTTGAAAC TTGAAGACACACCAAAGATCAACAGCCGCTTCTTTGGTGAAGGTACTAAGAAGATGGGCCTCGCATTTGAGAGCACCAAATCCACATCAC CTCCAAAGCAGGCCGAAGCTGTTTTGAAGACTCTCCAGGAACTGAAAAAACTAACCATCTCTGAGCAAAATATCCAGAGAGCTAATCTCT TCAATAAGCTGGTTACTGAGCTGAGAGGCCTCAGTGATGAAGCAGTCACATCTCTCTTGCCACAGCTGATTGAGGTGTCCAGCCCCATCA CTTTACAAGCCTTGGTTCAGTGTGGACAGCCTCAGTGCTCCACTCACATCCTCCAGTGGCTGAAACGTGTGCATGCCAACCCCCTTCTGA TAGATGTGGTCACCTACCTGGTGGCCCTGATCCCCGAGCCCTCAGCACAGCAGCTGCGAGAGATCTTCAACATGGCGAGGGATCAGCGCA GCCGAGCCACCTTGTATGCGCTGAGCCACGCGGTCAACAACTATCATAAGACAAACCCTACAGGGACCCAGGAGCTGCTGGACATTGCTA ATTACCTGATGGAACAGATTCAAGATGACTGCACTGGGGATGAAGATTACACCTATTTGATTCTGCGGGTCATTGGAAATATGGGCCAAA CCATGGAGCAGTTAACTCCAGAACTCAAGTCTTCAATCCTGAAATGTGTCCAAAGTACAAAGCCATCACTGATGATCCAGAAAGCTGCCA TCCAGGCTCTGCGGAAAATGGAGCCTAAAGACAAGGTGGCTTCCCACACTTCTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCG TGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAAGTCTCCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGA AAGCGCTGCAGGAATACCGCAAAAAGCACCGGGAGGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCC CCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCT CTCCCCGCTCTGGATCCTGCACTCTAACACTCGACTCTGCTGCTCATGGGAAGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAA CTGTCTTGTGAGCTGATCGCTTGGAGGGTCCTCTTTTTATGTTGAGTTGCTGCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGC AGGGGGGATGGAAAATAAGTAGAAACAAAAAAGCAGTGGCTAAGATGGTATAGGGACTGTCATACCAGTGAAGAATAAAAGGGTGAAGAA >5530_5530_2_APOB-CLU_APOB_chr2_21252511_ENST00000233242_CLU_chr8_27456152_ENST00000405140_length(amino acids)=602AA_BP=541 MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD -------------------------------------------------------------- >5530_5530_3_APOB-CLU_APOB_chr2_21252511_ENST00000233242_CLU_chr8_27456152_ENST00000523500_length(transcript)=2176nt_BP=1745nt ATTCCCACCGGGACCTGCGGGGCTGAGTGCCCTTCTCGGTTGCTGCCGCTGAGGAGCCCGCCCAGCCAGCCAGGGCCGCGAGGCCGAGGC CAGGCCGCAGCCCAGGAGCCGCCCCACCGCAGCTGGCGATGGACCCGCCGAGGCCCGCGCTGCTGGCGCTGCTGGCGCTGCCTGCGCTGC TGCTGCTGCTGCTGGCGGGCGCCAGGGCCGAAGAGGAAATGCTGGAAAATGTCAGCCTGGTCTGTCCAAAAGATGCGACCCGATTCAAGC ACCTCCGGAAGTACACATACAACTATGAGGCTGAGAGTTCCAGTGGAGTCCCTGGGACTGCTGATTCAAGAAGTGCCACCAGGATCAACT GCAAGGTTGAGCTGGAGGTTCCCCAGCTCTGCAGCTTCATCCTGAAGACCAGCCAGTGCACCCTGAAAGAGGTGTATGGCTTCAACCCTG AGGGCAAAGCCTTGCTGAAGAAAACCAAGAACTCTGAGGAGTTTGCTGCAGCCATGTCCAGGTATGAGCTCAAGCTGGCCATTCCAGAAG GGAAGCAGGTTTTCCTTTACCCGGAGAAAGATGAACCTACTTACATCCTGAACATCAAGAGGGGCATCATTTCTGCCCTCCTGGTTCCCC CAGAGACAGAAGAAGCCAAGCAAGTGTTGTTTCTGGATACCGTGTATGGAAACTGCTCCACTCACTTTACCGTCAAGACGAGGAAGGGCA ATGTGGCAACAGAAATATCCACTGAAAGAGACCTGGGGCAGTGTGATCGCTTCAAGCCCATCCGCACAGGCATCAGCCCACTTGCTCTCA TCAAAGGCATGACCCGCCCCTTGTCAACTCTGATCAGCAGCAGCCAGTCCTGTCAGTACACACTGGACGCTAAGAGGAAGCATGTGGCAG AAGCCATCTGCAAGGAGCAACACCTCTTCCTGCCTTTCTCCTACAAGAATAAGTATGGGATGGTAGCACAAGTGACACAGACTTTGAAAC TTGAAGACACACCAAAGATCAACAGCCGCTTCTTTGGTGAAGGTACTAAGAAGATGGGCCTCGCATTTGAGAGCACCAAATCCACATCAC CTCCAAAGCAGGCCGAAGCTGTTTTGAAGACTCTCCAGGAACTGAAAAAACTAACCATCTCTGAGCAAAATATCCAGAGAGCTAATCTCT TCAATAAGCTGGTTACTGAGCTGAGAGGCCTCAGTGATGAAGCAGTCACATCTCTCTTGCCACAGCTGATTGAGGTGTCCAGCCCCATCA CTTTACAAGCCTTGGTTCAGTGTGGACAGCCTCAGTGCTCCACTCACATCCTCCAGTGGCTGAAACGTGTGCATGCCAACCCCCTTCTGA TAGATGTGGTCACCTACCTGGTGGCCCTGATCCCCGAGCCCTCAGCACAGCAGCTGCGAGAGATCTTCAACATGGCGAGGGATCAGCGCA GCCGAGCCACCTTGTATGCGCTGAGCCACGCGGTCAACAACTATCATAAGACAAACCCTACAGGGACCCAGGAGCTGCTGGACATTGCTA ATTACCTGATGGAACAGATTCAAGATGACTGCACTGGGGATGAAGATTACACCTATTTGATTCTGCGGGTCATTGGAAATATGGGCCAAA CCATGGAGCAGTTAACTCCAGAACTCAAGTCTTCAATCCTGAAATGTGTCCAAAGTACAAAGCCATCACTGATGATCCAGAAAGCTGCCA TCCAGGCTCTGCGGAAAATGGAGCCTAAAGACAAGGTGGCTTCCCACACTTCTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCG TGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAAGTCTCCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGA AAGCGCTGCAGGAATACCGCAAAAAGCACCGGGAGGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCC CCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCT CTCCCCGCTCTGGATCCTGCACTCTAACACTCGACTCTGCTGCTCATGGGAAGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAA >5530_5530_3_APOB-CLU_APOB_chr2_21252511_ENST00000233242_CLU_chr8_27456152_ENST00000523500_length(amino acids)=602AA_BP=541 MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD -------------------------------------------------------------- >5530_5530_4_APOB-CLU_APOB_chr2_21252511_ENST00000233242_CLU_chr8_27456152_ENST00000546343_length(transcript)=3237nt_BP=1745nt ATTCCCACCGGGACCTGCGGGGCTGAGTGCCCTTCTCGGTTGCTGCCGCTGAGGAGCCCGCCCAGCCAGCCAGGGCCGCGAGGCCGAGGC CAGGCCGCAGCCCAGGAGCCGCCCCACCGCAGCTGGCGATGGACCCGCCGAGGCCCGCGCTGCTGGCGCTGCTGGCGCTGCCTGCGCTGC TGCTGCTGCTGCTGGCGGGCGCCAGGGCCGAAGAGGAAATGCTGGAAAATGTCAGCCTGGTCTGTCCAAAAGATGCGACCCGATTCAAGC ACCTCCGGAAGTACACATACAACTATGAGGCTGAGAGTTCCAGTGGAGTCCCTGGGACTGCTGATTCAAGAAGTGCCACCAGGATCAACT GCAAGGTTGAGCTGGAGGTTCCCCAGCTCTGCAGCTTCATCCTGAAGACCAGCCAGTGCACCCTGAAAGAGGTGTATGGCTTCAACCCTG AGGGCAAAGCCTTGCTGAAGAAAACCAAGAACTCTGAGGAGTTTGCTGCAGCCATGTCCAGGTATGAGCTCAAGCTGGCCATTCCAGAAG GGAAGCAGGTTTTCCTTTACCCGGAGAAAGATGAACCTACTTACATCCTGAACATCAAGAGGGGCATCATTTCTGCCCTCCTGGTTCCCC CAGAGACAGAAGAAGCCAAGCAAGTGTTGTTTCTGGATACCGTGTATGGAAACTGCTCCACTCACTTTACCGTCAAGACGAGGAAGGGCA ATGTGGCAACAGAAATATCCACTGAAAGAGACCTGGGGCAGTGTGATCGCTTCAAGCCCATCCGCACAGGCATCAGCCCACTTGCTCTCA TCAAAGGCATGACCCGCCCCTTGTCAACTCTGATCAGCAGCAGCCAGTCCTGTCAGTACACACTGGACGCTAAGAGGAAGCATGTGGCAG AAGCCATCTGCAAGGAGCAACACCTCTTCCTGCCTTTCTCCTACAAGAATAAGTATGGGATGGTAGCACAAGTGACACAGACTTTGAAAC TTGAAGACACACCAAAGATCAACAGCCGCTTCTTTGGTGAAGGTACTAAGAAGATGGGCCTCGCATTTGAGAGCACCAAATCCACATCAC CTCCAAAGCAGGCCGAAGCTGTTTTGAAGACTCTCCAGGAACTGAAAAAACTAACCATCTCTGAGCAAAATATCCAGAGAGCTAATCTCT TCAATAAGCTGGTTACTGAGCTGAGAGGCCTCAGTGATGAAGCAGTCACATCTCTCTTGCCACAGCTGATTGAGGTGTCCAGCCCCATCA CTTTACAAGCCTTGGTTCAGTGTGGACAGCCTCAGTGCTCCACTCACATCCTCCAGTGGCTGAAACGTGTGCATGCCAACCCCCTTCTGA TAGATGTGGTCACCTACCTGGTGGCCCTGATCCCCGAGCCCTCAGCACAGCAGCTGCGAGAGATCTTCAACATGGCGAGGGATCAGCGCA GCCGAGCCACCTTGTATGCGCTGAGCCACGCGGTCAACAACTATCATAAGACAAACCCTACAGGGACCCAGGAGCTGCTGGACATTGCTA ATTACCTGATGGAACAGATTCAAGATGACTGCACTGGGGATGAAGATTACACCTATTTGATTCTGCGGGTCATTGGAAATATGGGCCAAA CCATGGAGCAGTTAACTCCAGAACTCAAGTCTTCAATCCTGAAATGTGTCCAAAGTACAAAGCCATCACTGATGATCCAGAAAGCTGCCA TCCAGGCTCTGCGGAAAATGGAGCCTAAAGACAAGGTGGCTTCCCACACTTCTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCG TGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAAGTCTCCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGA AAGCGCTGCAGGAATACCGCAAAAAGCACCGGGAGGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCC CCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCT CTCCCCGCTCTGGATCCTGCACTCTAACACTCGACTCTGCTGCTCATGGGAAGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAA CTGTCTTGTGAGCTGATCGCTTGGAGGGTCCTCTTTTTATGTTGAGTTGCTGCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGC AGGGGGGATGGAAAATAAGTAGAAACAAAAAAGCAGTGGCTAAGATGGTATAGGGACTGTCATACCAGTGAAGAATAAAAGGGTGAAGAA TAAAAGGGATATGATGACAAGGTTGATCCACTTCAAGAATTGCTTGCTTTCAGGAAGAGAGATGTGTTTCAACAAGCCAACTAAAATATA TTGCTGCAAATGGAAGCTTTTCTGTTCTATTATAAAACTGTCGATGTATTCTGACCAAGGTGCGACAATCTCCTAAAGGAATACACTGAA AGTTAAGGAGAAGAATCAGTAAGTGTAAGGTGTACTTGGTATTATAATGCATAATTGATGTTTTCGTTATGAAAACATTTGGTGCCCAGA AGTCCAAATTATCAGTTTTATTTGTAAGAGCTATTGCTTTTGCAGCGGTTTTATTTGTAAAAGCTGTTGATTTCGAGTTGTAAGAGCTCA GCATCCCAGGGGCATCTTCTTGACTGTGGCATTTCCTGTCCACCGCCGGTTTATATGATCTTCATACCTTTCCCTGGACCACAGGCGTTT CTCGGCTTTTAGTCTGAACCATAGCTGGGCTGCAGTACCCTACGCTGCCAGCAGGTGGCCATGACTACCCGTGGTACCAATCTCAGTCTT AAAGCTCAGGCTTTTCGTTCATTAACATTCTCTGATAGAATTCTGGTCATCAGATGTACTGCAATGGAACAAAACTCATCTGGCTGCATC CCAGGTGTGTAGCAAAGTCCACATGTAAATTTATAGCTTAGAATATTCTTAAGTCACTGTCCCTTGTCTCTCTTTGAAGTTATAAACAAC AAACTTAAAGCTTAGCTTATGTCCAAGGTAAGTATTTTAGCATGGCTGTCAAGGAAATTCAGAGTAAAGTCAGTGTGATTCACTTAATGA >5530_5530_4_APOB-CLU_APOB_chr2_21252511_ENST00000233242_CLU_chr8_27456152_ENST00000546343_length(amino acids)=602AA_BP=541 MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD -------------------------------------------------------------- >5530_5530_5_APOB-CLU_APOB_chr2_21252511_ENST00000233242_CLU_chr8_27456152_ENST00000560366_length(transcript)=3237nt_BP=1745nt ATTCCCACCGGGACCTGCGGGGCTGAGTGCCCTTCTCGGTTGCTGCCGCTGAGGAGCCCGCCCAGCCAGCCAGGGCCGCGAGGCCGAGGC CAGGCCGCAGCCCAGGAGCCGCCCCACCGCAGCTGGCGATGGACCCGCCGAGGCCCGCGCTGCTGGCGCTGCTGGCGCTGCCTGCGCTGC TGCTGCTGCTGCTGGCGGGCGCCAGGGCCGAAGAGGAAATGCTGGAAAATGTCAGCCTGGTCTGTCCAAAAGATGCGACCCGATTCAAGC ACCTCCGGAAGTACACATACAACTATGAGGCTGAGAGTTCCAGTGGAGTCCCTGGGACTGCTGATTCAAGAAGTGCCACCAGGATCAACT GCAAGGTTGAGCTGGAGGTTCCCCAGCTCTGCAGCTTCATCCTGAAGACCAGCCAGTGCACCCTGAAAGAGGTGTATGGCTTCAACCCTG AGGGCAAAGCCTTGCTGAAGAAAACCAAGAACTCTGAGGAGTTTGCTGCAGCCATGTCCAGGTATGAGCTCAAGCTGGCCATTCCAGAAG GGAAGCAGGTTTTCCTTTACCCGGAGAAAGATGAACCTACTTACATCCTGAACATCAAGAGGGGCATCATTTCTGCCCTCCTGGTTCCCC CAGAGACAGAAGAAGCCAAGCAAGTGTTGTTTCTGGATACCGTGTATGGAAACTGCTCCACTCACTTTACCGTCAAGACGAGGAAGGGCA ATGTGGCAACAGAAATATCCACTGAAAGAGACCTGGGGCAGTGTGATCGCTTCAAGCCCATCCGCACAGGCATCAGCCCACTTGCTCTCA TCAAAGGCATGACCCGCCCCTTGTCAACTCTGATCAGCAGCAGCCAGTCCTGTCAGTACACACTGGACGCTAAGAGGAAGCATGTGGCAG AAGCCATCTGCAAGGAGCAACACCTCTTCCTGCCTTTCTCCTACAAGAATAAGTATGGGATGGTAGCACAAGTGACACAGACTTTGAAAC TTGAAGACACACCAAAGATCAACAGCCGCTTCTTTGGTGAAGGTACTAAGAAGATGGGCCTCGCATTTGAGAGCACCAAATCCACATCAC CTCCAAAGCAGGCCGAAGCTGTTTTGAAGACTCTCCAGGAACTGAAAAAACTAACCATCTCTGAGCAAAATATCCAGAGAGCTAATCTCT TCAATAAGCTGGTTACTGAGCTGAGAGGCCTCAGTGATGAAGCAGTCACATCTCTCTTGCCACAGCTGATTGAGGTGTCCAGCCCCATCA CTTTACAAGCCTTGGTTCAGTGTGGACAGCCTCAGTGCTCCACTCACATCCTCCAGTGGCTGAAACGTGTGCATGCCAACCCCCTTCTGA TAGATGTGGTCACCTACCTGGTGGCCCTGATCCCCGAGCCCTCAGCACAGCAGCTGCGAGAGATCTTCAACATGGCGAGGGATCAGCGCA GCCGAGCCACCTTGTATGCGCTGAGCCACGCGGTCAACAACTATCATAAGACAAACCCTACAGGGACCCAGGAGCTGCTGGACATTGCTA ATTACCTGATGGAACAGATTCAAGATGACTGCACTGGGGATGAAGATTACACCTATTTGATTCTGCGGGTCATTGGAAATATGGGCCAAA CCATGGAGCAGTTAACTCCAGAACTCAAGTCTTCAATCCTGAAATGTGTCCAAAGTACAAAGCCATCACTGATGATCCAGAAAGCTGCCA TCCAGGCTCTGCGGAAAATGGAGCCTAAAGACAAGGTGGCTTCCCACACTTCTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCG TGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAAGTCTCCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGA AAGCGCTGCAGGAATACCGCAAAAAGCACCGGGAGGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCC CCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCT CTCCCCGCTCTGGATCCTGCACTCTAACACTCGACTCTGCTGCTCATGGGAAGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAA CTGTCTTGTGAGCTGATCGCTTGGAGGGTCCTCTTTTTATGTTGAGTTGCTGCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGC AGGGGGGATGGAAAATAAGTAGAAACAAAAAAGCAGTGGCTAAGATGGTATAGGGACTGTCATACCAGTGAAGAATAAAAGGGTGAAGAA TAAAAGGGATATGATGACAAGGTTGATCCACTTCAAGAATTGCTTGCTTTCAGGAAGAGAGATGTGTTTCAACAAGCCAACTAAAATATA TTGCTGCAAATGGAAGCTTTTCTGTTCTATTATAAAACTGTCGATGTATTCTGACCAAGGTGCGACAATCTCCTAAAGGAATACACTGAA AGTTAAGGAGAAGAATCAGTAAGTGTAAGGTGTACTTGGTATTATAATGCATAATTGATGTTTTCGTTATGAAAACATTTGGTGCCCAGA AGTCCAAATTATCAGTTTTATTTGTAAGAGCTATTGCTTTTGCAGCGGTTTTATTTGTAAAAGCTGTTGATTTCGAGTTGTAAGAGCTCA GCATCCCAGGGGCATCTTCTTGACTGTGGCATTTCCTGTCCACCGCCGGTTTATATGATCTTCATACCTTTCCCTGGACCACAGGCGTTT CTCGGCTTTTAGTCTGAACCATAGCTGGGCTGCAGTACCCTACGCTGCCAGCAGGTGGCCATGACTACCCGTGGTACCAATCTCAGTCTT AAAGCTCAGGCTTTTCGTTCATTAACATTCTCTGATAGAATTCTGGTCATCAGATGTACTGCAATGGAACAAAACTCATCTGGCTGCATC CCAGGTGTGTAGCAAAGTCCACATGTAAATTTATAGCTTAGAATATTCTTAAGTCACTGTCCCTTGTCTCTCTTTGAAGTTATAAACAAC AAACTTAAAGCTTAGCTTATGTCCAAGGTAAGTATTTTAGCATGGCTGTCAAGGAAATTCAGAGTAAAGTCAGTGTGATTCACTTAATGA >5530_5530_5_APOB-CLU_APOB_chr2_21252511_ENST00000233242_CLU_chr8_27456152_ENST00000560366_length(amino acids)=602AA_BP=541 MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD -------------------------------------------------------------- >5530_5530_6_APOB-CLU_APOB_chr2_21252511_ENST00000399256_CLU_chr8_27456152_ENST00000316403_length(transcript)=3144nt_BP=1634nt CCCCACCGCAGCTGGCGATGGACCCGCCGAGGCCCGCGCTGCTGGCGCTGCTGGCGCTGCCTGCGCTGCTGCTGCTGCTGCTGGCGGGCG CCAGGGCCGAAGAGGAAATGCTGGAAAATGTCAGCCTGGTCTGTCCAAAAGATGCGACCCGATTCAAGCACCTCCGGAAGTACACATACA ACTATGAGGCTGAGAGTTCCAGTGGAGTCCCTGGGACTGCTGATTCAAGAAGTGCCACCAGGATCAACTGCAAGGTTGAGCTGGAGGTTC CCCAGCTCTGCAGCTTCATCCTGAAGACCAGCCAGTGCACCCTGAAAGAGGTGTATGGCTTCAACCCTGAGGGCAAAGCCTTGCTGAAGA AAACCAAGAACTCTGAGGAGTTTGCTGCAGCCATGTCCAGGTATGAGCTCAAGCTGGCCATTCCAGAAGGGAAGCAGGTTTTCCTTTACC CGGAGAAAGATGAACCTACTTACATCCTGAACATCAAGAGGGGCATCATTTCTGCCCTCCTGGTTCCCCCAGAGACAGAAGAAGCCAAGC AAGTGTTGTTTCTGGATACCGTGTATGGAAACTGCTCCACTCACTTTACCGTCAAGACGAGGAAGGGCAATGTGGCAACAGAAATATCCA CTGAAAGAGACCTGGGGCAGTGTGATCGCTTCAAGCCCATCCGCACAGGCATCAGCCCACTTGCTCTCATCAAAGGCATGACCCGCCCCT TGTCAACTCTGATCAGCAGCAGCCAGTCCTGTCAGTACACACTGGACGCTAAGAGGAAGCATGTGGCAGAAGCCATCTGCAAGGAGCAAC ACCTCTTCCTGCCTTTCTCCTACAAGAATAAGTATGGGATGGTAGCACAAGTGACACAGACTTTGAAACTTGAAGACACACCAAAGATCA ACAGCCGCTTCTTTGGTGAAGGTACTAAGAAGATGGGCCTCGCATTTGAGAGCACCAAATCCACATCACCTCCAAAGCAGGCCGAAGCTG TTTTGAAGACTCTCCAGGAACTGAAAAAACTAACCATCTCTGAGCAAAATATCCAGAGAGCTAATCTCTTCAATAAGCTGGTTACTGAGC TGAGAGGCCTCAGTGATGAAGCAGTCACATCTCTCTTGCCACAGCTGATTGAGGTGTCCAGCCCCATCACTTTACAAGCCTTGGTTCAGT GTGGACAGCCTCAGTGCTCCACTCACATCCTCCAGTGGCTGAAACGTGTGCATGCCAACCCCCTTCTGATAGATGTGGTCACCTACCTGG TGGCCCTGATCCCCGAGCCCTCAGCACAGCAGCTGCGAGAGATCTTCAACATGGCGAGGGATCAGCGCAGCCGAGCCACCTTGTATGCGC TGAGCCACGCGGTCAACAACTATCATAAGACAAACCCTACAGGGACCCAGGAGCTGCTGGACATTGCTAATTACCTGATGGAACAGATTC AAGATGACTGCACTGGGGATGAAGATTACACCTATTTGATTCTGCGGGTCATTGGAAATATGGGCCAAACCATGGAGCAGTTAACTCCAG AACTCAAGTCTTCAATCCTGAAATGTGTCCAAAGTACAAAGCCATCACTGATGATCCAGAAAGCTGCCATCCAGGCTCTGCGGAAAATGG AGCCTAAAGACAAGGTGGCTTCCCACACTTCTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATC CCATCACTGTGACGGTCCCTGTAGAAGTCTCCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGAAAGCGCTGCAGGAATACCGCA AAAAGCACCGGGAGGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCC CCAGAGAGAGCTCTGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCA CTCTAACACTCGACTCTGCTGCTCATGGGAAGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGATCGCT TGGAGGGTCCTCTTTTTATGTTGAGTTGCTGCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGCAGGGGGGATGGAAAATAAGTA GAAACAAAAAAGCAGTGGCTAAGATGGTATAGGGACTGTCATACCAGTGAAGAATAAAAGGGTGAAGAATAAAAGGGATATGATGACAAG GTTGATCCACTTCAAGAATTGCTTGCTTTCAGGAAGAGAGATGTGTTTCAACAAGCCAACTAAAATATATTGCTGCAAATGGAAGCTTTT CTGTTCTATTATAAAACTGTCGATGTATTCTGACCAAGGTGCGACAATCTCCTAAAGGAATACACTGAAAGTTAAGGAGAAGAATCAGTA AGTGTAAGGTGTACTTGGTATTATAATGCATAATTGATGTTTTCGTTATGAAAACATTTGGTGCCCAGAAGTCCAAATTATCAGTTTTAT TTGTAAGAGCTATTGCTTTTGCAGCGGTTTTATTTGTAAAAGCTGTTGATTTCGAGTTGTAAGAGCTCAGCATCCCAGGGGCATCTTCTT GACTGTGGCATTTCCTGTCCACCGCCGGTTTATATGATCTTCATACCTTTCCCTGGACCACAGGCGTTTCTCGGCTTTTAGTCTGAACCA TAGCTGGGCTGCAGTACCCTACGCTGCCAGCAGGTGGCCATGACTACCCGTGGTACCAATCTCAGTCTTAAAGCTCAGGCTTTTCGTTCA TTAACATTCTCTGATAGAATTCTGGTCATCAGATGTACTGCAATGGAACAAAACTCATCTGGCTGCATCCCAGGTGTGTAGCAAAGTCCA CATGTAAATTTATAGCTTAGAATATTCTTAAGTCACTGTCCCTTGTCTCTCTTTGAAGTTATAAACAACAAACTTAAAGCTTAGCTTATG TCCAAGGTAAGTATTTTAGCATGGCTGTCAAGGAAATTCAGAGTAAAGTCAGTGTGATTCACTTAATGATATACATTAATTAGAATTATG >5530_5530_6_APOB-CLU_APOB_chr2_21252511_ENST00000399256_CLU_chr8_27456152_ENST00000316403_length(amino acids)=602AA_BP=541 MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD -------------------------------------------------------------- >5530_5530_7_APOB-CLU_APOB_chr2_21252511_ENST00000399256_CLU_chr8_27456152_ENST00000405140_length(transcript)=2253nt_BP=1634nt CCCCACCGCAGCTGGCGATGGACCCGCCGAGGCCCGCGCTGCTGGCGCTGCTGGCGCTGCCTGCGCTGCTGCTGCTGCTGCTGGCGGGCG CCAGGGCCGAAGAGGAAATGCTGGAAAATGTCAGCCTGGTCTGTCCAAAAGATGCGACCCGATTCAAGCACCTCCGGAAGTACACATACA ACTATGAGGCTGAGAGTTCCAGTGGAGTCCCTGGGACTGCTGATTCAAGAAGTGCCACCAGGATCAACTGCAAGGTTGAGCTGGAGGTTC CCCAGCTCTGCAGCTTCATCCTGAAGACCAGCCAGTGCACCCTGAAAGAGGTGTATGGCTTCAACCCTGAGGGCAAAGCCTTGCTGAAGA AAACCAAGAACTCTGAGGAGTTTGCTGCAGCCATGTCCAGGTATGAGCTCAAGCTGGCCATTCCAGAAGGGAAGCAGGTTTTCCTTTACC CGGAGAAAGATGAACCTACTTACATCCTGAACATCAAGAGGGGCATCATTTCTGCCCTCCTGGTTCCCCCAGAGACAGAAGAAGCCAAGC AAGTGTTGTTTCTGGATACCGTGTATGGAAACTGCTCCACTCACTTTACCGTCAAGACGAGGAAGGGCAATGTGGCAACAGAAATATCCA CTGAAAGAGACCTGGGGCAGTGTGATCGCTTCAAGCCCATCCGCACAGGCATCAGCCCACTTGCTCTCATCAAAGGCATGACCCGCCCCT TGTCAACTCTGATCAGCAGCAGCCAGTCCTGTCAGTACACACTGGACGCTAAGAGGAAGCATGTGGCAGAAGCCATCTGCAAGGAGCAAC ACCTCTTCCTGCCTTTCTCCTACAAGAATAAGTATGGGATGGTAGCACAAGTGACACAGACTTTGAAACTTGAAGACACACCAAAGATCA ACAGCCGCTTCTTTGGTGAAGGTACTAAGAAGATGGGCCTCGCATTTGAGAGCACCAAATCCACATCACCTCCAAAGCAGGCCGAAGCTG TTTTGAAGACTCTCCAGGAACTGAAAAAACTAACCATCTCTGAGCAAAATATCCAGAGAGCTAATCTCTTCAATAAGCTGGTTACTGAGC TGAGAGGCCTCAGTGATGAAGCAGTCACATCTCTCTTGCCACAGCTGATTGAGGTGTCCAGCCCCATCACTTTACAAGCCTTGGTTCAGT GTGGACAGCCTCAGTGCTCCACTCACATCCTCCAGTGGCTGAAACGTGTGCATGCCAACCCCCTTCTGATAGATGTGGTCACCTACCTGG TGGCCCTGATCCCCGAGCCCTCAGCACAGCAGCTGCGAGAGATCTTCAACATGGCGAGGGATCAGCGCAGCCGAGCCACCTTGTATGCGC TGAGCCACGCGGTCAACAACTATCATAAGACAAACCCTACAGGGACCCAGGAGCTGCTGGACATTGCTAATTACCTGATGGAACAGATTC AAGATGACTGCACTGGGGATGAAGATTACACCTATTTGATTCTGCGGGTCATTGGAAATATGGGCCAAACCATGGAGCAGTTAACTCCAG AACTCAAGTCTTCAATCCTGAAATGTGTCCAAAGTACAAAGCCATCACTGATGATCCAGAAAGCTGCCATCCAGGCTCTGCGGAAAATGG AGCCTAAAGACAAGGTGGCTTCCCACACTTCTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATC CCATCACTGTGACGGTCCCTGTAGAAGTCTCCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGAAAGCGCTGCAGGAATACCGCA AAAAGCACCGGGAGGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCC CCAGAGAGAGCTCTGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCA CTCTAACACTCGACTCTGCTGCTCATGGGAAGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGATCGCT TGGAGGGTCCTCTTTTTATGTTGAGTTGCTGCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGCAGGGGGGATGGAAAATAAGTA GAAACAAAAAAGCAGTGGCTAAGATGGTATAGGGACTGTCATACCAGTGAAGAATAAAAGGGTGAAGAATAAAAGGGATATGATGACAAG >5530_5530_7_APOB-CLU_APOB_chr2_21252511_ENST00000399256_CLU_chr8_27456152_ENST00000405140_length(amino acids)=602AA_BP=541 MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD -------------------------------------------------------------- >5530_5530_8_APOB-CLU_APOB_chr2_21252511_ENST00000399256_CLU_chr8_27456152_ENST00000523500_length(transcript)=2065nt_BP=1634nt CCCCACCGCAGCTGGCGATGGACCCGCCGAGGCCCGCGCTGCTGGCGCTGCTGGCGCTGCCTGCGCTGCTGCTGCTGCTGCTGGCGGGCG CCAGGGCCGAAGAGGAAATGCTGGAAAATGTCAGCCTGGTCTGTCCAAAAGATGCGACCCGATTCAAGCACCTCCGGAAGTACACATACA ACTATGAGGCTGAGAGTTCCAGTGGAGTCCCTGGGACTGCTGATTCAAGAAGTGCCACCAGGATCAACTGCAAGGTTGAGCTGGAGGTTC CCCAGCTCTGCAGCTTCATCCTGAAGACCAGCCAGTGCACCCTGAAAGAGGTGTATGGCTTCAACCCTGAGGGCAAAGCCTTGCTGAAGA AAACCAAGAACTCTGAGGAGTTTGCTGCAGCCATGTCCAGGTATGAGCTCAAGCTGGCCATTCCAGAAGGGAAGCAGGTTTTCCTTTACC CGGAGAAAGATGAACCTACTTACATCCTGAACATCAAGAGGGGCATCATTTCTGCCCTCCTGGTTCCCCCAGAGACAGAAGAAGCCAAGC AAGTGTTGTTTCTGGATACCGTGTATGGAAACTGCTCCACTCACTTTACCGTCAAGACGAGGAAGGGCAATGTGGCAACAGAAATATCCA CTGAAAGAGACCTGGGGCAGTGTGATCGCTTCAAGCCCATCCGCACAGGCATCAGCCCACTTGCTCTCATCAAAGGCATGACCCGCCCCT TGTCAACTCTGATCAGCAGCAGCCAGTCCTGTCAGTACACACTGGACGCTAAGAGGAAGCATGTGGCAGAAGCCATCTGCAAGGAGCAAC ACCTCTTCCTGCCTTTCTCCTACAAGAATAAGTATGGGATGGTAGCACAAGTGACACAGACTTTGAAACTTGAAGACACACCAAAGATCA ACAGCCGCTTCTTTGGTGAAGGTACTAAGAAGATGGGCCTCGCATTTGAGAGCACCAAATCCACATCACCTCCAAAGCAGGCCGAAGCTG TTTTGAAGACTCTCCAGGAACTGAAAAAACTAACCATCTCTGAGCAAAATATCCAGAGAGCTAATCTCTTCAATAAGCTGGTTACTGAGC TGAGAGGCCTCAGTGATGAAGCAGTCACATCTCTCTTGCCACAGCTGATTGAGGTGTCCAGCCCCATCACTTTACAAGCCTTGGTTCAGT GTGGACAGCCTCAGTGCTCCACTCACATCCTCCAGTGGCTGAAACGTGTGCATGCCAACCCCCTTCTGATAGATGTGGTCACCTACCTGG TGGCCCTGATCCCCGAGCCCTCAGCACAGCAGCTGCGAGAGATCTTCAACATGGCGAGGGATCAGCGCAGCCGAGCCACCTTGTATGCGC TGAGCCACGCGGTCAACAACTATCATAAGACAAACCCTACAGGGACCCAGGAGCTGCTGGACATTGCTAATTACCTGATGGAACAGATTC AAGATGACTGCACTGGGGATGAAGATTACACCTATTTGATTCTGCGGGTCATTGGAAATATGGGCCAAACCATGGAGCAGTTAACTCCAG AACTCAAGTCTTCAATCCTGAAATGTGTCCAAAGTACAAAGCCATCACTGATGATCCAGAAAGCTGCCATCCAGGCTCTGCGGAAAATGG AGCCTAAAGACAAGGTGGCTTCCCACACTTCTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATC CCATCACTGTGACGGTCCCTGTAGAAGTCTCCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGAAAGCGCTGCAGGAATACCGCA AAAAGCACCGGGAGGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCC CCAGAGAGAGCTCTGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCA >5530_5530_8_APOB-CLU_APOB_chr2_21252511_ENST00000399256_CLU_chr8_27456152_ENST00000523500_length(amino acids)=602AA_BP=541 MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD -------------------------------------------------------------- >5530_5530_9_APOB-CLU_APOB_chr2_21252511_ENST00000399256_CLU_chr8_27456152_ENST00000546343_length(transcript)=3126nt_BP=1634nt CCCCACCGCAGCTGGCGATGGACCCGCCGAGGCCCGCGCTGCTGGCGCTGCTGGCGCTGCCTGCGCTGCTGCTGCTGCTGCTGGCGGGCG CCAGGGCCGAAGAGGAAATGCTGGAAAATGTCAGCCTGGTCTGTCCAAAAGATGCGACCCGATTCAAGCACCTCCGGAAGTACACATACA ACTATGAGGCTGAGAGTTCCAGTGGAGTCCCTGGGACTGCTGATTCAAGAAGTGCCACCAGGATCAACTGCAAGGTTGAGCTGGAGGTTC CCCAGCTCTGCAGCTTCATCCTGAAGACCAGCCAGTGCACCCTGAAAGAGGTGTATGGCTTCAACCCTGAGGGCAAAGCCTTGCTGAAGA AAACCAAGAACTCTGAGGAGTTTGCTGCAGCCATGTCCAGGTATGAGCTCAAGCTGGCCATTCCAGAAGGGAAGCAGGTTTTCCTTTACC CGGAGAAAGATGAACCTACTTACATCCTGAACATCAAGAGGGGCATCATTTCTGCCCTCCTGGTTCCCCCAGAGACAGAAGAAGCCAAGC AAGTGTTGTTTCTGGATACCGTGTATGGAAACTGCTCCACTCACTTTACCGTCAAGACGAGGAAGGGCAATGTGGCAACAGAAATATCCA CTGAAAGAGACCTGGGGCAGTGTGATCGCTTCAAGCCCATCCGCACAGGCATCAGCCCACTTGCTCTCATCAAAGGCATGACCCGCCCCT TGTCAACTCTGATCAGCAGCAGCCAGTCCTGTCAGTACACACTGGACGCTAAGAGGAAGCATGTGGCAGAAGCCATCTGCAAGGAGCAAC ACCTCTTCCTGCCTTTCTCCTACAAGAATAAGTATGGGATGGTAGCACAAGTGACACAGACTTTGAAACTTGAAGACACACCAAAGATCA ACAGCCGCTTCTTTGGTGAAGGTACTAAGAAGATGGGCCTCGCATTTGAGAGCACCAAATCCACATCACCTCCAAAGCAGGCCGAAGCTG TTTTGAAGACTCTCCAGGAACTGAAAAAACTAACCATCTCTGAGCAAAATATCCAGAGAGCTAATCTCTTCAATAAGCTGGTTACTGAGC TGAGAGGCCTCAGTGATGAAGCAGTCACATCTCTCTTGCCACAGCTGATTGAGGTGTCCAGCCCCATCACTTTACAAGCCTTGGTTCAGT GTGGACAGCCTCAGTGCTCCACTCACATCCTCCAGTGGCTGAAACGTGTGCATGCCAACCCCCTTCTGATAGATGTGGTCACCTACCTGG TGGCCCTGATCCCCGAGCCCTCAGCACAGCAGCTGCGAGAGATCTTCAACATGGCGAGGGATCAGCGCAGCCGAGCCACCTTGTATGCGC TGAGCCACGCGGTCAACAACTATCATAAGACAAACCCTACAGGGACCCAGGAGCTGCTGGACATTGCTAATTACCTGATGGAACAGATTC AAGATGACTGCACTGGGGATGAAGATTACACCTATTTGATTCTGCGGGTCATTGGAAATATGGGCCAAACCATGGAGCAGTTAACTCCAG AACTCAAGTCTTCAATCCTGAAATGTGTCCAAAGTACAAAGCCATCACTGATGATCCAGAAAGCTGCCATCCAGGCTCTGCGGAAAATGG AGCCTAAAGACAAGGTGGCTTCCCACACTTCTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATC CCATCACTGTGACGGTCCCTGTAGAAGTCTCCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGAAAGCGCTGCAGGAATACCGCA AAAAGCACCGGGAGGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCC CCAGAGAGAGCTCTGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCA CTCTAACACTCGACTCTGCTGCTCATGGGAAGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGATCGCT TGGAGGGTCCTCTTTTTATGTTGAGTTGCTGCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGCAGGGGGGATGGAAAATAAGTA GAAACAAAAAAGCAGTGGCTAAGATGGTATAGGGACTGTCATACCAGTGAAGAATAAAAGGGTGAAGAATAAAAGGGATATGATGACAAG GTTGATCCACTTCAAGAATTGCTTGCTTTCAGGAAGAGAGATGTGTTTCAACAAGCCAACTAAAATATATTGCTGCAAATGGAAGCTTTT CTGTTCTATTATAAAACTGTCGATGTATTCTGACCAAGGTGCGACAATCTCCTAAAGGAATACACTGAAAGTTAAGGAGAAGAATCAGTA AGTGTAAGGTGTACTTGGTATTATAATGCATAATTGATGTTTTCGTTATGAAAACATTTGGTGCCCAGAAGTCCAAATTATCAGTTTTAT TTGTAAGAGCTATTGCTTTTGCAGCGGTTTTATTTGTAAAAGCTGTTGATTTCGAGTTGTAAGAGCTCAGCATCCCAGGGGCATCTTCTT GACTGTGGCATTTCCTGTCCACCGCCGGTTTATATGATCTTCATACCTTTCCCTGGACCACAGGCGTTTCTCGGCTTTTAGTCTGAACCA TAGCTGGGCTGCAGTACCCTACGCTGCCAGCAGGTGGCCATGACTACCCGTGGTACCAATCTCAGTCTTAAAGCTCAGGCTTTTCGTTCA TTAACATTCTCTGATAGAATTCTGGTCATCAGATGTACTGCAATGGAACAAAACTCATCTGGCTGCATCCCAGGTGTGTAGCAAAGTCCA CATGTAAATTTATAGCTTAGAATATTCTTAAGTCACTGTCCCTTGTCTCTCTTTGAAGTTATAAACAACAAACTTAAAGCTTAGCTTATG TCCAAGGTAAGTATTTTAGCATGGCTGTCAAGGAAATTCAGAGTAAAGTCAGTGTGATTCACTTAATGATATACATTAATTAGAATTATG >5530_5530_9_APOB-CLU_APOB_chr2_21252511_ENST00000399256_CLU_chr8_27456152_ENST00000546343_length(amino acids)=602AA_BP=541 MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD -------------------------------------------------------------- >5530_5530_10_APOB-CLU_APOB_chr2_21252511_ENST00000399256_CLU_chr8_27456152_ENST00000560366_length(transcript)=3126nt_BP=1634nt CCCCACCGCAGCTGGCGATGGACCCGCCGAGGCCCGCGCTGCTGGCGCTGCTGGCGCTGCCTGCGCTGCTGCTGCTGCTGCTGGCGGGCG CCAGGGCCGAAGAGGAAATGCTGGAAAATGTCAGCCTGGTCTGTCCAAAAGATGCGACCCGATTCAAGCACCTCCGGAAGTACACATACA ACTATGAGGCTGAGAGTTCCAGTGGAGTCCCTGGGACTGCTGATTCAAGAAGTGCCACCAGGATCAACTGCAAGGTTGAGCTGGAGGTTC CCCAGCTCTGCAGCTTCATCCTGAAGACCAGCCAGTGCACCCTGAAAGAGGTGTATGGCTTCAACCCTGAGGGCAAAGCCTTGCTGAAGA AAACCAAGAACTCTGAGGAGTTTGCTGCAGCCATGTCCAGGTATGAGCTCAAGCTGGCCATTCCAGAAGGGAAGCAGGTTTTCCTTTACC CGGAGAAAGATGAACCTACTTACATCCTGAACATCAAGAGGGGCATCATTTCTGCCCTCCTGGTTCCCCCAGAGACAGAAGAAGCCAAGC AAGTGTTGTTTCTGGATACCGTGTATGGAAACTGCTCCACTCACTTTACCGTCAAGACGAGGAAGGGCAATGTGGCAACAGAAATATCCA CTGAAAGAGACCTGGGGCAGTGTGATCGCTTCAAGCCCATCCGCACAGGCATCAGCCCACTTGCTCTCATCAAAGGCATGACCCGCCCCT TGTCAACTCTGATCAGCAGCAGCCAGTCCTGTCAGTACACACTGGACGCTAAGAGGAAGCATGTGGCAGAAGCCATCTGCAAGGAGCAAC ACCTCTTCCTGCCTTTCTCCTACAAGAATAAGTATGGGATGGTAGCACAAGTGACACAGACTTTGAAACTTGAAGACACACCAAAGATCA ACAGCCGCTTCTTTGGTGAAGGTACTAAGAAGATGGGCCTCGCATTTGAGAGCACCAAATCCACATCACCTCCAAAGCAGGCCGAAGCTG TTTTGAAGACTCTCCAGGAACTGAAAAAACTAACCATCTCTGAGCAAAATATCCAGAGAGCTAATCTCTTCAATAAGCTGGTTACTGAGC TGAGAGGCCTCAGTGATGAAGCAGTCACATCTCTCTTGCCACAGCTGATTGAGGTGTCCAGCCCCATCACTTTACAAGCCTTGGTTCAGT GTGGACAGCCTCAGTGCTCCACTCACATCCTCCAGTGGCTGAAACGTGTGCATGCCAACCCCCTTCTGATAGATGTGGTCACCTACCTGG TGGCCCTGATCCCCGAGCCCTCAGCACAGCAGCTGCGAGAGATCTTCAACATGGCGAGGGATCAGCGCAGCCGAGCCACCTTGTATGCGC TGAGCCACGCGGTCAACAACTATCATAAGACAAACCCTACAGGGACCCAGGAGCTGCTGGACATTGCTAATTACCTGATGGAACAGATTC AAGATGACTGCACTGGGGATGAAGATTACACCTATTTGATTCTGCGGGTCATTGGAAATATGGGCCAAACCATGGAGCAGTTAACTCCAG AACTCAAGTCTTCAATCCTGAAATGTGTCCAAAGTACAAAGCCATCACTGATGATCCAGAAAGCTGCCATCCAGGCTCTGCGGAAAATGG AGCCTAAAGACAAGGTGGCTTCCCACACTTCTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATC CCATCACTGTGACGGTCCCTGTAGAAGTCTCCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGAAAGCGCTGCAGGAATACCGCA AAAAGCACCGGGAGGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCC CCAGAGAGAGCTCTGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCA CTCTAACACTCGACTCTGCTGCTCATGGGAAGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGATCGCT TGGAGGGTCCTCTTTTTATGTTGAGTTGCTGCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGCAGGGGGGATGGAAAATAAGTA GAAACAAAAAAGCAGTGGCTAAGATGGTATAGGGACTGTCATACCAGTGAAGAATAAAAGGGTGAAGAATAAAAGGGATATGATGACAAG GTTGATCCACTTCAAGAATTGCTTGCTTTCAGGAAGAGAGATGTGTTTCAACAAGCCAACTAAAATATATTGCTGCAAATGGAAGCTTTT CTGTTCTATTATAAAACTGTCGATGTATTCTGACCAAGGTGCGACAATCTCCTAAAGGAATACACTGAAAGTTAAGGAGAAGAATCAGTA AGTGTAAGGTGTACTTGGTATTATAATGCATAATTGATGTTTTCGTTATGAAAACATTTGGTGCCCAGAAGTCCAAATTATCAGTTTTAT TTGTAAGAGCTATTGCTTTTGCAGCGGTTTTATTTGTAAAAGCTGTTGATTTCGAGTTGTAAGAGCTCAGCATCCCAGGGGCATCTTCTT GACTGTGGCATTTCCTGTCCACCGCCGGTTTATATGATCTTCATACCTTTCCCTGGACCACAGGCGTTTCTCGGCTTTTAGTCTGAACCA TAGCTGGGCTGCAGTACCCTACGCTGCCAGCAGGTGGCCATGACTACCCGTGGTACCAATCTCAGTCTTAAAGCTCAGGCTTTTCGTTCA TTAACATTCTCTGATAGAATTCTGGTCATCAGATGTACTGCAATGGAACAAAACTCATCTGGCTGCATCCCAGGTGTGTAGCAAAGTCCA CATGTAAATTTATAGCTTAGAATATTCTTAAGTCACTGTCCCTTGTCTCTCTTTGAAGTTATAAACAACAAACTTAAAGCTTAGCTTATG TCCAAGGTAAGTATTTTAGCATGGCTGTCAAGGAAATTCAGAGTAAAGTCAGTGTGATTCACTTAATGATATACATTAATTAGAATTATG >5530_5530_10_APOB-CLU_APOB_chr2_21252511_ENST00000399256_CLU_chr8_27456152_ENST00000560366_length(amino acids)=602AA_BP=541 MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for APOB-CLU |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for APOB-CLU |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | APOB | P04114 | DB14548 | Zinc sulfate, unspecified form | Ligand | Small molecule | Approved|Experimental |
| Hgene | APOB | P04114 | DB14533 | Zinc chloride | Ligand | Small molecule | Approved|Investigational |
| Tgene | CLU | P10909 | DB14548 | Zinc sulfate, unspecified form | Inducer | Small molecule | Approved|Experimental |
| Tgene | CLU | P10909 | DB14548 | Zinc sulfate, unspecified form | Inducer | Small molecule | Approved|Experimental |
| Tgene | CLU | P10909 | DB14548 | Zinc sulfate, unspecified form | Inducer | Small molecule | Approved|Experimental |
| Tgene | CLU | P10909 | DB14548 | Zinc sulfate, unspecified form | Inducer | Small molecule | Approved|Experimental |
| Tgene | CLU | P10909 | DB14548 | Zinc sulfate, unspecified form | Inducer | Small molecule | Approved|Experimental |
| Tgene | CLU | P10909 | DB01593 | Zinc | Small molecule | Approved|Investigational | |
| Tgene | CLU | P10909 | DB01593 | Zinc | Small molecule | Approved|Investigational | |
| Tgene | CLU | P10909 | DB01593 | Zinc | Small molecule | Approved|Investigational | |
| Tgene | CLU | P10909 | DB01593 | Zinc | Small molecule | Approved|Investigational | |
| Tgene | CLU | P10909 | DB01593 | Zinc | Small molecule | Approved|Investigational | |
| Tgene | CLU | P10909 | DB09130 | Copper | Small molecule | Approved|Investigational | |
| Tgene | CLU | P10909 | DB09130 | Copper | Small molecule | Approved|Investigational | |
| Tgene | CLU | P10909 | DB09130 | Copper | Small molecule | Approved|Investigational | |
| Tgene | CLU | P10909 | DB09130 | Copper | Small molecule | Approved|Investigational | |
| Tgene | CLU | P10909 | DB09130 | Copper | Small molecule | Approved|Investigational | |
| Tgene | CLU | P10909 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
| Tgene | CLU | P10909 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
| Tgene | CLU | P10909 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
| Tgene | CLU | P10909 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
| Tgene | CLU | P10909 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
| Tgene | CLU | P10909 | DB14533 | Zinc chloride | Inducer | Small molecule | Approved|Investigational |
| Tgene | CLU | P10909 | DB14533 | Zinc chloride | Inducer | Small molecule | Approved|Investigational |
| Tgene | CLU | P10909 | DB14533 | Zinc chloride | Inducer | Small molecule | Approved|Investigational |
| Tgene | CLU | P10909 | DB14533 | Zinc chloride | Inducer | Small molecule | Approved|Investigational |
| Tgene | CLU | P10909 | DB14533 | Zinc chloride | Inducer | Small molecule | Approved|Investigational |
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Related Diseases for APOB-CLU |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | APOB | C1704417 | Hyperlipoproteinemia Type IIb | 17 | CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Hgene | APOB | C3888316 | Hypercholesterolemia, familial, due to ligand-defective apolipoprotein B | 10 | CLINGEN |
| Hgene | APOB | C4551990 | Acanthocytosis With Hypobetalipoproteinemia | 5 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Hgene | APOB | C0020443 | Hypercholesterolemia | 3 | CTD_human;GENOMICS_ENGLAND |
| Hgene | APOB | C0020445 | Hypercholesterolemia, Familial | 3 | CTD_human;GENOMICS_ENGLAND |
| Hgene | APOB | C1704299 | Hypobetalipoproteinemia, Familial, Apolipoprotein B | 3 | CTD_human |
| Hgene | APOB | C0007222 | Cardiovascular Diseases | 2 | CTD_human |
| Hgene | APOB | C0015695 | Fatty Liver | 2 | CTD_human |
| Hgene | APOB | C2711227 | Steatohepatitis | 2 | CTD_human |
| Hgene | APOB | C0004943 | Behcet Syndrome | 1 | CTD_human |
| Hgene | APOB | C0007570 | Celiac Disease | 1 | CTD_human |
| Hgene | APOB | C0010068 | Coronary heart disease | 1 | CTD_human |
| Hgene | APOB | C0020473 | Hyperlipidemia | 1 | CTD_human |
| Hgene | APOB | C0020557 | Hypertriglyceridemia | 1 | CTD_human |
| Hgene | APOB | C0242339 | Dyslipidemias | 1 | CTD_human |
| Hgene | APOB | C0598784 | Dyslipoproteinemias | 1 | CTD_human |
| Hgene | APOB | C0745103 | Hyperlipoproteinemia Type IIa | 1 | CTD_human |
| Hgene | APOB | C1706412 | Lipidemias | 1 | CTD_human |
| Hgene | APOB | C1848533 | Ataxia with vitamin E deficiency | 1 | CTD_human |
| Tgene | C0022660 | Kidney Failure, Acute | 6 | CTD_human | |
| Tgene | C1565662 | Acute Kidney Insufficiency | 6 | CTD_human | |
| Tgene | C2609414 | Acute kidney injury | 6 | CTD_human | |
| Tgene | C0002395 | Alzheimer's Disease | 3 | CTD_human | |
| Tgene | C0011265 | Presenile dementia | 3 | CTD_human | |
| Tgene | C0022658 | Kidney Diseases | 3 | CTD_human | |
| Tgene | C0276496 | Familial Alzheimer Disease (FAD) | 3 | CTD_human | |
| Tgene | C0494463 | Alzheimer Disease, Late Onset | 3 | CTD_human | |
| Tgene | C0546126 | Acute Confusional Senile Dementia | 3 | CTD_human | |
| Tgene | C0750900 | Alzheimer's Disease, Focal Onset | 3 | CTD_human | |
| Tgene | C0750901 | Alzheimer Disease, Early Onset | 3 | CTD_human | |
| Tgene | C0013221 | Drug toxicity | 2 | CTD_human | |
| Tgene | C0029408 | Degenerative polyarthritis | 2 | CTD_human | |
| Tgene | C0041755 | Adverse reaction to drug | 2 | CTD_human | |
| Tgene | C0086743 | Osteoarthrosis Deformans | 2 | CTD_human | |
| Tgene | C0019193 | Hepatitis, Toxic | 1 | CTD_human | |
| Tgene | C0022333 | Jacksonian Seizure | 1 | CTD_human | |
| Tgene | C0024141 | Lupus Erythematosus, Systemic | 1 | CTD_human | |
| Tgene | C0025202 | melanoma | 1 | CTD_human | |
| Tgene | C0027686 | Pathologic Neovascularization | 1 | CTD_human | |
| Tgene | C0033578 | Prostatic Neoplasms | 1 | CTD_human | |
| Tgene | C0036341 | Schizophrenia | 1 | PSYGENET | |
| Tgene | C0036572 | Seizures | 1 | CTD_human | |
| Tgene | C0087031 | Juvenile-Onset Still Disease | 1 | CTD_human | |
| Tgene | C0149958 | Complex partial seizures | 1 | CTD_human | |
| Tgene | C0234533 | Generalized seizures | 1 | CTD_human | |
| Tgene | C0234535 | Clonic Seizures | 1 | CTD_human | |
| Tgene | C0234985 | Mental deterioration | 1 | CTD_human | |
| Tgene | C0242380 | Libman-Sacks Disease | 1 | CTD_human | |
| Tgene | C0270824 | Visual seizure | 1 | CTD_human | |
| Tgene | C0270844 | Tonic Seizures | 1 | CTD_human | |
| Tgene | C0270846 | Epileptic drop attack | 1 | CTD_human | |
| Tgene | C0333641 | Atrophic | 1 | CTD_human | |
| Tgene | C0338656 | Impaired cognition | 1 | CTD_human | |
| Tgene | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human | |
| Tgene | C0422850 | Seizures, Somatosensory | 1 | CTD_human | |
| Tgene | C0422852 | Seizures, Auditory | 1 | CTD_human | |
| Tgene | C0422853 | Olfactory seizure | 1 | CTD_human | |
| Tgene | C0422854 | Gustatory seizure | 1 | CTD_human | |
| Tgene | C0422855 | Vertiginous seizure | 1 | CTD_human | |
| Tgene | C0494475 | Tonic - clonic seizures | 1 | CTD_human | |
| Tgene | C0751056 | Non-epileptic convulsion | 1 | CTD_human | |
| Tgene | C0751110 | Single Seizure | 1 | CTD_human | |
| Tgene | C0751123 | Atonic Absence Seizures | 1 | CTD_human | |
| Tgene | C0751494 | Convulsive Seizures | 1 | CTD_human | |
| Tgene | C0751495 | Seizures, Focal | 1 | CTD_human | |
| Tgene | C0751496 | Seizures, Sensory | 1 | CTD_human | |
| Tgene | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human | |
| Tgene | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human | |
| Tgene | C1270972 | Mild cognitive disorder | 1 | CTD_human | |
| Tgene | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human | |
| Tgene | C1862941 | Amyotrophic Lateral Sclerosis, Sporadic | 1 | CTD_human | |
| Tgene | C3495559 | Juvenile arthritis | 1 | CTD_human | |
| Tgene | C3495874 | Nonepileptic Seizures | 1 | CTD_human | |
| Tgene | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human | |
| Tgene | C3714758 | Juvenile psoriatic arthritis | 1 | CTD_human | |
| Tgene | C4048158 | Convulsions | 1 | CTD_human | |
| Tgene | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human | |
| Tgene | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human | |
| Tgene | C4316903 | Absence Seizures | 1 | CTD_human | |
| Tgene | C4317109 | Epileptic Seizures | 1 | CTD_human | |
| Tgene | C4317123 | Myoclonic Seizures | 1 | CTD_human | |
| Tgene | C4505436 | Generalized Absence Seizures | 1 | CTD_human | |
| Tgene | C4551993 | Amyotrophic Lateral Sclerosis, Familial | 1 | CTD_human | |
| Tgene | C4552091 | Polyarthritis, Juvenile, Rheumatoid Factor Negative | 1 | CTD_human | |
| Tgene | C4704862 | Polyarthritis, Juvenile, Rheumatoid Factor Positive | 1 | CTD_human |
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