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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IL1B-DPYSL2 (FusionGDB2 ID:HG3553TG1808)

Fusion Gene Summary for IL1B-DPYSL2

check button Fusion gene summary
Fusion gene informationFusion gene name: IL1B-DPYSL2
Fusion gene ID: hg3553tg1808
HgeneTgene
Gene symbol

IL1B

DPYSL2

Gene ID

3553

1808

Gene nameinterleukin 1 betadihydropyrimidinase like 2
SynonymsIL-1|IL1-BETA|IL1F2|IL1betaCRMP-2|CRMP2|DHPRP2|DRP-2|DRP2|N2A3|ULIP-2|ULIP2
Cytomap('IL1B')('DPYSL2')

2q14.1

8p21.2

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-1 betaIL-1 betacatabolininterleukin 1betapreinterleukin 1 betapro-interleukin-1-betadihydropyrimidinase-related protein 2collapsin response mediator protein hCRMP-2unc-33-like phosphoprotein 2
Modification date2020032920200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263341, ENST00000491056, 
Fusion gene scores* DoF score2 X 3 X 1=610 X 10 X 4=400
# samples 315
** MAII scorelog2(3/6*10)=2.32192809488736log2(15/400*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IL1B [Title/Abstract] AND DPYSL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIL1B(113587328)-DPYSL2(26435921), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIL1B

GO:0000187

activation of MAPK activity

10748004

HgeneIL1B

GO:0001934

positive regulation of protein phosphorylation

10748004

HgeneIL1B

GO:0006954

inflammatory response

10748004|21147091

HgeneIL1B

GO:0008284

positive regulation of cell proliferation

25204733

HgeneIL1B

GO:0008285

negative regulation of cell proliferation

3493774

HgeneIL1B

GO:0010575

positive regulation of vascular endothelial growth factor production

12958148

HgeneIL1B

GO:0010628

positive regulation of gene expression

11090614|21559518|23817958|25327529|26687115|29384235

HgeneIL1B

GO:0010718

positive regulation of epithelial to mesenchymal transition

25204733

HgeneIL1B

GO:0019221

cytokine-mediated signaling pathway

10748004

HgeneIL1B

GO:0030213

hyaluronan biosynthetic process

15100360

HgeneIL1B

GO:0030335

positive regulation of cell migration

25204733

HgeneIL1B

GO:0030730

sequestering of triglyceride

19032770

HgeneIL1B

GO:0031663

lipopolysaccharide-mediated signaling pathway

21147091

HgeneIL1B

GO:0032496

response to lipopolysaccharide

19193853

HgeneIL1B

GO:0032725

positive regulation of granulocyte macrophage colony-stimulating factor production

20027291

HgeneIL1B

GO:0032729

positive regulation of interferon-gamma production

10653850|20027291

HgeneIL1B

GO:0032757

positive regulation of interleukin-8 production

19524870

HgeneIL1B

GO:0034116

positive regulation of heterotypic cell-cell adhesion

15100360

HgeneIL1B

GO:0035505

positive regulation of myosin light chain kinase activity

18390750

HgeneIL1B

GO:0035690

cellular response to drug

19158679

HgeneIL1B

GO:0042102

positive regulation of T cell proliferation

1919436

HgeneIL1B

GO:0043122

regulation of I-kappaB kinase/NF-kappaB signaling

10748004

HgeneIL1B

GO:0045429

positive regulation of nitric oxide biosynthetic process

8383325

HgeneIL1B

GO:0045766

positive regulation of angiogenesis

25204733

HgeneIL1B

GO:0045893

positive regulation of transcription, DNA-templated

15100360

HgeneIL1B

GO:0050796

regulation of insulin secretion

8383325

HgeneIL1B

GO:0050995

negative regulation of lipid catabolic process

19032770

HgeneIL1B

GO:0050999

regulation of nitric-oxide synthase activity

15899045

HgeneIL1B

GO:0051044

positive regulation of membrane protein ectodomain proteolysis

18373975

HgeneIL1B

GO:0051091

positive regulation of DNA-binding transcription factor activity

10748004

HgeneIL1B

GO:0051092

positive regulation of NF-kappaB transcription factor activity

10383454|12958148|25327529

HgeneIL1B

GO:0060559

positive regulation of calcidiol 1-monooxygenase activity

16720713|17023519

HgeneIL1B

GO:0070372

regulation of ERK1 and ERK2 cascade

25204733

HgeneIL1B

GO:0070487

monocyte aggregation

15100360

HgeneIL1B

GO:0070498

interleukin-1-mediated signaling pathway

25327529

HgeneIL1B

GO:0070555

response to interleukin-1

29441883

HgeneIL1B

GO:0071310

cellular response to organic substance

19158679

HgeneIL1B

GO:0071407

cellular response to organic cyclic compound

21147091

HgeneIL1B

GO:0071639

positive regulation of monocyte chemotactic protein-1 production

19524870

HgeneIL1B

GO:1901224

positive regulation of NIK/NF-kappaB signaling

18390750

HgeneIL1B

GO:1902680

positive regulation of RNA biosynthetic process

29384235

HgeneIL1B

GO:1903140

regulation of establishment of endothelial barrier

25816133

HgeneIL1B

GO:1903597

negative regulation of gap junction assembly

11090614

HgeneIL1B

GO:2000556

positive regulation of T-helper 1 cell cytokine production

10653850

HgeneIL1B

GO:2001240

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

10748004



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACD240166IL1Bchr2

113587328

-DPYSL2chr8

26435921

-


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Fusion Gene ORF analysis for IL1B-DPYSL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263341ENST00000311151IL1Bchr2

113587328

-DPYSL2chr8

26435921

-
5CDS-intronENST00000263341ENST00000521913IL1Bchr2

113587328

-DPYSL2chr8

26435921

-
5CDS-intronENST00000263341ENST00000521983IL1Bchr2

113587328

-DPYSL2chr8

26435921

-
5CDS-intronENST00000263341ENST00000523027IL1Bchr2

113587328

-DPYSL2chr8

26435921

-
intron-intronENST00000491056ENST00000311151IL1Bchr2

113587328

-DPYSL2chr8

26435921

-
intron-intronENST00000491056ENST00000521913IL1Bchr2

113587328

-DPYSL2chr8

26435921

-
intron-intronENST00000491056ENST00000521983IL1Bchr2

113587328

-DPYSL2chr8

26435921

-
intron-intronENST00000491056ENST00000523027IL1Bchr2

113587328

-DPYSL2chr8

26435921

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for IL1B-DPYSL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IL1Bchr2113587327-DPYSL2chr826435920-0.99999881.15E-06
IL1Bchr2113587327-DPYSL2chr826435920-0.99999881.15E-06


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for IL1B-DPYSL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:113587328/:26435921)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for IL1B-DPYSL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for IL1B-DPYSL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IL1B-DPYSL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IL1B-DPYSL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIL1BC0021368Inflammation9CTD_human
HgeneIL1BC0020429Hyperalgesia6CTD_human
HgeneIL1BC0458247Allodynia6CTD_human
HgeneIL1BC0751211Hyperalgesia, Primary6CTD_human
HgeneIL1BC0751212Hyperalgesia, Secondary6CTD_human
HgeneIL1BC0751213Tactile Allodynia6CTD_human
HgeneIL1BC0751214Hyperalgesia, Thermal6CTD_human
HgeneIL1BC2936719Mechanical Allodynia6CTD_human
HgeneIL1BC0005586Bipolar Disorder5PSYGENET
HgeneIL1BC0011570Mental Depression5PSYGENET
HgeneIL1BC0011581Depressive disorder5PSYGENET
HgeneIL1BC0015967Fever5CTD_human
HgeneIL1BC0035126Reperfusion Injury5CTD_human
HgeneIL1BC0041696Unipolar Depression5PSYGENET
HgeneIL1BC1269683Major Depressive Disorder5PSYGENET
HgeneIL1BC0001973Alcoholic Intoxication, Chronic4PSYGENET
HgeneIL1BC0003865Arthritis, Adjuvant-Induced4CTD_human
HgeneIL1BC0007786Brain Ischemia4CTD_human
HgeneIL1BC0009324Ulcerative Colitis4CTD_human
HgeneIL1BC0917798Cerebral Ischemia4CTD_human
HgeneIL1BC0971858Arthritis, Collagen-Induced4CTD_human
HgeneIL1BC0993582Arthritis, Experimental4CTD_human
HgeneIL1BC0003873Rheumatoid Arthritis3CTD_human
HgeneIL1BC0006142Malignant neoplasm of breast3CTD_human
HgeneIL1BC0007102Malignant tumor of colon3CTD_human
HgeneIL1BC0009375Colonic Neoplasms3CTD_human
HgeneIL1BC0020538Hypertensive disease3CTD_human
HgeneIL1BC0024623Malignant neoplasm of stomach3CTD_human
HgeneIL1BC0027051Myocardial Infarction3CTD_human
HgeneIL1BC0027540Necrosis3CTD_human
HgeneIL1BC0038356Stomach Neoplasms3CTD_human
HgeneIL1BC0678222Breast Carcinoma3CTD_human
HgeneIL1BC1257931Mammary Neoplasms, Human3CTD_human
HgeneIL1BC1458155Mammary Neoplasms3CTD_human
HgeneIL1BC1708349Hereditary Diffuse Gastric Cancer3CTD_human
HgeneIL1BC4704874Mammary Carcinoma, Human3CTD_human
HgeneIL1BC0009319Colitis2CTD_human
HgeneIL1BC0017658Glomerulonephritis2CTD_human
HgeneIL1BC0019193Hepatitis, Toxic2CTD_human
HgeneIL1BC0020649Hypotension2CTD_human
HgeneIL1BC0024121Lung Neoplasms2CTD_human
HgeneIL1BC0026769Multiple Sclerosis2CTD_human
HgeneIL1BC0034069Pulmonary Fibrosis2CTD_human
HgeneIL1BC0037274Dermatologic disorders2CTD_human
HgeneIL1BC0242379Malignant neoplasm of lung2CTD_human
HgeneIL1BC0751324Multiple Sclerosis, Acute Fulminating2CTD_human
HgeneIL1BC0860207Drug-Induced Liver Disease2CTD_human
HgeneIL1BC1262760Hepatitis, Drug-Induced2CTD_human
HgeneIL1BC1704377Bright Disease2CTD_human
HgeneIL1BC3658290Drug-Induced Acute Liver Injury2CTD_human
HgeneIL1BC4277682Chemical and Drug Induced Liver Injury2CTD_human
HgeneIL1BC4279912Chemically-Induced Liver Toxicity2CTD_human
HgeneIL1BC4721507Alveolitis, Fibrosing2CTD_human
HgeneIL1BC0000786Spontaneous abortion1CTD_human
HgeneIL1BC0000822Abortion, Tubal1CTD_human
HgeneIL1BC0001418Adenocarcinoma1CTD_human
HgeneIL1BC0002152Alloxan Diabetes1CTD_human
HgeneIL1BC0002395Alzheimer's Disease1CTD_human
HgeneIL1BC0003123Anorexia1CTD_human
HgeneIL1BC0003165Anthracosis1CTD_human
HgeneIL1BC0004096Asthma1CTD_human
HgeneIL1BC0005398Cholestasis, Extrahepatic1CTD_human
HgeneIL1BC0006287Bronchopulmonary Dysplasia1CTD_human
HgeneIL1BC0006663Calcinosis1CTD_human
HgeneIL1BC0006826Malignant Neoplasms1CTD_human
HgeneIL1BC0011265Presenile dementia1CTD_human
HgeneIL1BC0011615Dermatitis, Atopic1CTD_human
HgeneIL1BC0011633Dermatomyositis1CTD_human
HgeneIL1BC0011853Diabetes Mellitus, Experimental1CTD_human
HgeneIL1BC0014324Entamoebiasis1CTD_human
HgeneIL1BC0016059Fibrosis1CTD_human
HgeneIL1BC0017154Gastritis, Atrophic1CTD_human
HgeneIL1BC0017636Glioblastoma1CTD_human
HgeneIL1BC0018099Gout1CTD_human
HgeneIL1BC0018800Cardiomegaly1CTD_human
HgeneIL1BC0018801Heart failure1CTD_human
HgeneIL1BC0018802Congestive heart failure1CTD_human
HgeneIL1BC0018824Heart valve disease1CTD_human
HgeneIL1BC0019061Hemolytic-Uremic Syndrome1CTD_human
HgeneIL1BC0020452Hyperemia1CTD_human
HgeneIL1BC0020517Hypersensitivity1CTD_human
HgeneIL1BC0020615Hypoglycemia1CTD_human
HgeneIL1BC0022333Jacksonian Seizure1CTD_human
HgeneIL1BC0022541Kearns-Sayre syndrome1CTD_human
HgeneIL1BC0023186Learning Disorders1CTD_human
HgeneIL1BC0023212Left-Sided Heart Failure1CTD_human
HgeneIL1BC0023283Leishmaniasis, Cutaneous1CTD_human
HgeneIL1BC0023290Leishmaniasis, Visceral1CTD_human
HgeneIL1BC0023380Lethargy1CTD_human
HgeneIL1BC0023518Leukocytosis1CTD_human
HgeneIL1BC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneIL1BC0024312Lymphopenia1CTD_human
HgeneIL1BC0024799Marginal ulcer1CTD_human
HgeneIL1BC0024809Marijuana Abuse1PSYGENET
HgeneIL1BC0025261Memory Disorders1CTD_human
HgeneIL1BC0026848Myopathy1CTD_human
HgeneIL1BC0027626Neoplasm Invasiveness1CTD_human
HgeneIL1BC0027651Neoplasms1CTD_human
HgeneIL1BC0027947Neutropenia1CTD_human
HgeneIL1BC0029408Degenerative polyarthritis1CTD_human
HgeneIL1BC0029458Osteoporosis, Postmenopausal1CTD_human
HgeneIL1BC0030246Pustulosis of Palms and Soles1CTD_human
HgeneIL1BC0030920Peptic Ulcer1CTD_human
HgeneIL1BC0032231Pleurisy1CTD_human
HgeneIL1BC0032285Pneumonia1CTD_human
HgeneIL1BC0032300Lobar Pneumonia1CTD_human
HgeneIL1BC0033141Cardiomyopathies, Primary1CTD_human
HgeneIL1BC0033860Psoriasis1CTD_human
HgeneIL1BC0036341Schizophrenia1CTD_human
HgeneIL1BC0036529Myocardial Diseases, Secondary1CTD_human
HgeneIL1BC0036572Seizures1CTD_human
HgeneIL1BC0037116Silicosis1CTD_human
HgeneIL1BC0038358Gastric ulcer1CTD_human
HgeneIL1BC0038433Streptozotocin Diabetes1CTD_human
HgeneIL1BC0038454Cerebrovascular accident1CTD_human
HgeneIL1BC0040136Thyroid Neoplasm1CTD_human
HgeneIL1BC0040997Trigeminal Neuralgia1CTD_human
HgeneIL1BC0042109Urticaria1CTD_human
HgeneIL1BC0042484Venous Engorgement1CTD_human
HgeneIL1BC0085655Polymyositis1CTD_human
HgeneIL1BC0086196Eczema, Infantile1CTD_human
HgeneIL1BC0086540Leishmaniasis, New World1CTD_human
HgeneIL1BC0086541Urban cutaneous leishmaniasis1CTD_human
HgeneIL1BC0086692Benign Neoplasm1CTD_human
HgeneIL1BC0086743Osteoarthrosis Deformans1CTD_human
HgeneIL1BC0149958Complex partial seizures1CTD_human
HgeneIL1BC0151468Thyroid Gland Follicular Adenoma1CTD_human
HgeneIL1BC0151744Myocardial Ischemia1CTD_human
HgeneIL1BC0151857Pleocytosis1CTD_human
HgeneIL1BC0162668Megaconial Myopathies1CTD_human
HgeneIL1BC0162669Pleoconial Myopathies1CTD_human
HgeneIL1BC0162670Mitochondrial Myopathies1CTD_human
HgeneIL1BC0162671MELAS Syndrome1CTD_human
HgeneIL1BC0162672MERRF Syndrome1CTD_human
HgeneIL1BC0162674Chronic progressive external ophthalmoplegia1CTD_human
HgeneIL1BC0178824Reactive Hyperemia1CTD_human
HgeneIL1BC0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneIL1BC0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneIL1BC0205643Carcinoma, Cribriform1CTD_human
HgeneIL1BC0205644Carcinoma, Granular Cell1CTD_human
HgeneIL1BC0205645Adenocarcinoma, Tubular1CTD_human
HgeneIL1BC0221056Adult type dermatomyositis1CTD_human
HgeneIL1BC0233794Memory impairment1CTD_human
HgeneIL1BC0234533Generalized seizures1CTD_human
HgeneIL1BC0234535Clonic Seizures1CTD_human
HgeneIL1BC0235527Heart Failure, Right-Sided1CTD_human
HgeneIL1BC0238281Middle Cerebral Artery Syndrome1CTD_human
HgeneIL1BC0263628Tumoral calcinosis1CTD_human
HgeneIL1BC0263666Dermatomyositis, Childhood Type1CTD_human
HgeneIL1BC0263984Polymyositis Ossificans1CTD_human
HgeneIL1BC0270824Visual seizure1CTD_human
HgeneIL1BC0270844Tonic Seizures1CTD_human
HgeneIL1BC0270846Epileptic drop attack1CTD_human
HgeneIL1BC0271708Fasting Hypoglycemia1CTD_human
HgeneIL1BC0271710Reactive hypoglycemia1CTD_human
HgeneIL1BC0274861Arsenic Poisoning, Inorganic1CTD_human
HgeneIL1BC0274862Nervous System, Organic Arsenic Poisoning1CTD_human
HgeneIL1BC0276496Familial Alzheimer Disease (FAD)1CTD_human
HgeneIL1BC0311375Arsenic Poisoning1CTD_human
HgeneIL1BC0333233Active Hyperemia1CTD_human
HgeneIL1BC0333355Inflammatory disease of mucous membrane1CTD_human
HgeneIL1BC0334588Giant Cell Glioblastoma1CTD_human
HgeneIL1BC0343755HIV Wasting Syndrome1CTD_human
HgeneIL1BC0393786Trigeminal Neuralgia, Idiopathic1CTD_human
HgeneIL1BC0393787Secondary Trigeminal Neuralgia1CTD_human
HgeneIL1BC0422850Seizures, Somatosensory1CTD_human
HgeneIL1BC0422852Seizures, Auditory1CTD_human
HgeneIL1BC0422853Olfactory seizure1CTD_human
HgeneIL1BC0422854Gustatory seizure1CTD_human
HgeneIL1BC0422855Vertiginous seizure1CTD_human
HgeneIL1BC0494463Alzheimer Disease, Late Onset1CTD_human
HgeneIL1BC0494475Tonic - clonic seizures1CTD_human
HgeneIL1BC0521174Microcalcification1CTD_human
HgeneIL1BC0546126Acute Confusional Senile Dementia1CTD_human
HgeneIL1BC0549473Thyroid carcinoma1CTD_human
HgeneIL1BC0554591Polymyositis, Idiopathic1CTD_human
HgeneIL1BC0677050Manganese Poisoning1CTD_human
HgeneIL1BC0740376Middle Cerebral Artery Thrombosis1CTD_human
HgeneIL1BC0740391Middle Cerebral Artery Occlusion1CTD_human
HgeneIL1BC0740392Infarction, Middle Cerebral Artery1CTD_human
HgeneIL1BC0750900Alzheimer's Disease, Focal Onset1CTD_human
HgeneIL1BC0750901Alzheimer Disease, Early Onset1CTD_human
HgeneIL1BC0751056Non-epileptic convulsion1CTD_human
HgeneIL1BC0751110Single Seizure1CTD_human
HgeneIL1BC0751123Atonic Absence Seizures1CTD_human
HgeneIL1BC0751262Adult Learning Disorders1CTD_human
HgeneIL1BC0751263Learning Disturbance1CTD_human
HgeneIL1BC0751265Learning Disabilities1CTD_human
HgeneIL1BC0751292Age-Related Memory Disorders1CTD_human
HgeneIL1BC0751293Memory Disorder, Semantic1CTD_human
HgeneIL1BC0751294Memory Disorder, Spatial1CTD_human
HgeneIL1BC0751295Memory Loss1CTD_human
HgeneIL1BC0751494Convulsive Seizures1CTD_human
HgeneIL1BC0751495Seizures, Focal1CTD_human
HgeneIL1BC0751496Seizures, Sensory1CTD_human
HgeneIL1BC0751508Long Sleeper Syndrome1CTD_human
HgeneIL1BC0751509Short Sleeper Syndrome1CTD_human
HgeneIL1BC0751510Sleep-Related Neurogenic Tachypnea1CTD_human
HgeneIL1BC0751511Subwakefullness Syndrome1CTD_human
HgeneIL1BC0751845Middle Cerebral Artery Embolus1CTD_human
HgeneIL1BC0751846Left Middle Cerebral Artery Infarction1CTD_human
HgeneIL1BC0751847Embolic Infarction, Middle Cerebral Artery1CTD_human
HgeneIL1BC0751848Thrombotic Infarction, Middle Cerebral Artery1CTD_human
HgeneIL1BC0751849Right Middle Cerebral Artery Infarction1CTD_human
HgeneIL1BC0751851Arsenic Encephalopathy1CTD_human
HgeneIL1BC0751852Arsenic Induced Polyneuropathy1CTD_human
HgeneIL1BC0751956Acute Cerebrovascular Accidents1CTD_human
HgeneIL1BC0851578Sleep Disorders1CTD_human
HgeneIL1BC0878544Cardiomyopathies1CTD_human
HgeneIL1BC0887898Experimental Lung Inflammation1CTD_human
HgeneIL1BC0917796Optic Atrophy, Hereditary, Leber1CTD_human
HgeneIL1BC0949496Luft Disease1CTD_human
HgeneIL1BC1330966Developmental Academic Disorder1CTD_human
HgeneIL1BC1383860Cardiac Hypertrophy1CTD_human
HgeneIL1BC1527304Allergic Reaction1CTD_human
HgeneIL1BC1621958Glioblastoma Multiforme1CTD_human
HgeneIL1BC1623038Cirrhosis1CTD_human
HgeneIL1BC1858361Pyogenic Arthritis, Pyoderma Gangrenosum and Acne1CTD_human
HgeneIL1BC1959583Myocardial Failure1CTD_human
HgeneIL1BC1961112Heart Decompensation1CTD_human
HgeneIL1BC3495874Nonepileptic Seizures1CTD_human
HgeneIL1BC3714636Pneumonitis1CTD_human
HgeneIL1BC3830362Early Pregnancy Loss1CTD_human
HgeneIL1BC4042891Sleep Wake Disorders1CTD_human
HgeneIL1BC4048158Convulsions1CTD_human
HgeneIL1BC4316791Entamoeba histolytica Infection1CTD_human
HgeneIL1BC4316903Absence Seizures1CTD_human
HgeneIL1BC4317109Epileptic Seizures1CTD_human
HgeneIL1BC4317123Myoclonic Seizures1CTD_human
HgeneIL1BC4505436Generalized Absence Seizures1CTD_human
HgeneIL1BC4552766Miscarriage1CTD_human
TgeneC0005586Bipolar Disorder4PSYGENET
TgeneC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneC0002395Alzheimer's Disease1CTD_human
TgeneC0011251Delusional disorder1CTD_human
TgeneC0011265Presenile dementia1CTD_human
TgeneC0011570Mental Depression1PSYGENET
TgeneC0011581Depressive disorder1PSYGENET
TgeneC0029408Degenerative polyarthritis1CTD_human
TgeneC0036349Paranoid Schizophrenia1CTD_human
TgeneC0086743Osteoarthrosis Deformans1CTD_human
TgeneC0276496Familial Alzheimer Disease (FAD)1CTD_human
TgeneC0494463Alzheimer Disease, Late Onset1CTD_human
TgeneC0546126Acute Confusional Senile Dementia1CTD_human
TgeneC0750900Alzheimer's Disease, Focal Onset1CTD_human
TgeneC0750901Alzheimer Disease, Early Onset1CTD_human