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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:IL1RN-TAP2 (FusionGDB2 ID:HG3557TG6891)

Fusion Gene Summary for IL1RN-TAP2

Fusion gene summary

Fusion gene information	Fusion gene name: IL1RN-TAP2
	Fusion gene ID: hg3557tg6891
		Hgene	Tgene
	Gene symbol	IL1RN	TAP2
	Gene ID	3557	6891
	Gene name	interleukin 1 receptor antagonist	transporter 2, ATP binding cassette subfamily B member
	Synonyms	DIRA\|ICIL-1RA\|IL-1RN\|IL-1ra\|IL-1ra3\|IL1F3\|IL1RA\|IRAP\|MVCD4	ABC18\|ABCB3\|APT2\|D6S217E\|PSF-2\|PSF2\|RING11
	Cytomap	('IL1RN')('TAP2') 2q14.1	6p21.32
	Type of gene	protein-coding	protein-coding
	Description	interleukin-1 receptor antagonist proteinIL1 inhibitorintracellular IL-1 receptor antagonist type IIintracellular interleukin-1 receptor antagonist (icIL-1ra)type II interleukin-1 receptor antagonist	antigen peptide transporter 2ABC transporter, MHC 2ATP-binding cassette, sub-family B (MDR/TAP), member 3peptide supply factor 2peptide transporter PSF2peptide transporter involved in antigen processing 2really interesting new gene 11 proteintransp
	Modification date	20200329	20200322
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000259206, ENST00000354115, ENST00000361779, ENST00000409052, ENST00000409930, ENST00000465812,
Fusion gene scores	* DoF score	8 X 8 X 4=256	1 X 1 X 1=1
	# samples	8	1
	** MAII score	log2(8/256*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: IL1RN [Title/Abstract] AND TAP2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	IL1RN(113891005)-TAP2(32801312), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	IL1RN	GO:0034115	negative regulation of heterotypic cell-cell adhesion	2139180
Hgene	IL1RN	GO:0051384	response to glucocorticoid	10443688
Hgene	IL1RN	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	2137200\|2139180
Tgene	TAP2	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	8496691
Tgene	TAP2	GO:0046968	peptide antigen transport	8496691

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AW610198	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+

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Fusion Gene ORF analysis for IL1RN-TAP2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-intron	ENST00000259206	ENST00000374897	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000374899	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000383118	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000383119	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000383239	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000383240	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000414145	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000419142	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000426977	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000439425	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000443713	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000445986	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000451907	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000452371	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000452392	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000455842	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000457634	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000460458	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000463174	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000468636	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000469427	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000474736	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000485701	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000490573	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000259206	ENST00000490587	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000374897	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000374899	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000383118	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000383119	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000383239	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000383240	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000414145	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000419142	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000426977	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000439425	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000443713	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000445986	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000451907	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000452371	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000452392	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000455842	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000457634	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000460458	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000463174	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000468636	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000469427	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000474736	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000485701	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000490573	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000354115	ENST00000490587	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000374897	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000374899	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000383118	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000383119	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000383239	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000383240	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000414145	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000419142	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000426977	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000439425	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000443713	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000445986	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000451907	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000452371	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000452392	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000455842	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000457634	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000460458	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000463174	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000468636	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000469427	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000474736	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000485701	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000490573	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000361779	ENST00000490587	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000374897	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000374899	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000383118	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000383119	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000383239	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000383240	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000414145	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000419142	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000426977	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000439425	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000443713	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000445986	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000451907	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000452371	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000452392	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000455842	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000457634	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000460458	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000463174	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000468636	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000469427	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000474736	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000485701	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000490573	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
3UTR-intron	ENST00000409052	ENST00000490587	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000374897	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000374899	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000383118	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000383119	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000383239	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000383240	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000414145	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000419142	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000426977	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000439425	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000443713	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000445986	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000451907	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000452371	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000452392	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000455842	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000457634	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000460458	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000463174	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000468636	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000469427	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000474736	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000485701	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000490573	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000409930	ENST00000490587	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000374897	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000374899	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000383118	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000383119	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000383239	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000383240	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000414145	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000419142	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000426977	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000439425	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000443713	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000445986	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000451907	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000452371	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000452392	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000455842	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000457634	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000460458	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000463174	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000468636	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000469427	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000474736	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000485701	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000490573	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+
intron-intron	ENST00000465812	ENST00000490587	IL1RN	chr2	113891005	-	TAP2	chr6	32801312	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for IL1RN-TAP2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

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Fusion Protein Features for IL1RN-TAP2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:113891005/:32801312)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for IL1RN-TAP2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for IL1RN-TAP2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for IL1RN-TAP2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for IL1RN-TAP2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	IL1RN	C0020429	Hyperalgesia	4	CTD_human
Hgene	IL1RN	C0458247	Allodynia	4	CTD_human
Hgene	IL1RN	C0751211	Hyperalgesia, Primary	4	CTD_human
Hgene	IL1RN	C0751212	Hyperalgesia, Secondary	4	CTD_human
Hgene	IL1RN	C0751213	Tactile Allodynia	4	CTD_human
Hgene	IL1RN	C0751214	Hyperalgesia, Thermal	4	CTD_human
Hgene	IL1RN	C2936719	Mechanical Allodynia	4	CTD_human
Hgene	IL1RN	C0001973	Alcoholic Intoxication, Chronic	2	PSYGENET
Hgene	IL1RN	C0003873	Rheumatoid Arthritis	2	CTD_human
Hgene	IL1RN	C0005586	Bipolar Disorder	2	PSYGENET
Hgene	IL1RN	C0011206	Delirium	2	PSYGENET
Hgene	IL1RN	C0027051	Myocardial Infarction	2	CTD_human
Hgene	IL1RN	C0027540	Necrosis	2	CTD_human
Hgene	IL1RN	C0033578	Prostatic Neoplasms	2	CTD_human
Hgene	IL1RN	C0037274	Dermatologic disorders	2	CTD_human
Hgene	IL1RN	C0376358	Malignant neoplasm of prostate	2	CTD_human
Hgene	IL1RN	C2748507	INTERLEUKIN 1 RECEPTOR ANTAGONIST DEFICIENCY	2	CTD_human;GENOMICS_ENGLAND;ORPHANET
Hgene	IL1RN	C0003123	Anorexia	1	CTD_human
Hgene	IL1RN	C0003165	Anthracosis	1	CTD_human
Hgene	IL1RN	C0004096	Asthma	1	CTD_human
Hgene	IL1RN	C0004352	Autistic Disorder	1	CTD_human
Hgene	IL1RN	C0007102	Malignant tumor of colon	1	CTD_human
Hgene	IL1RN	C0007786	Brain Ischemia	1	CTD_human
Hgene	IL1RN	C0009375	Colonic Neoplasms	1	CTD_human
Hgene	IL1RN	C0011991	Diarrhea	1	CTD_human
Hgene	IL1RN	C0013415	Dysthymic Disorder	1	PSYGENET
Hgene	IL1RN	C0015230	Exanthema	1	CTD_human
Hgene	IL1RN	C0015378	Extravasation of Contrast Media	1	CTD_human
Hgene	IL1RN	C0015967	Fever	1	CTD_human
Hgene	IL1RN	C0016059	Fibrosis	1	CTD_human
Hgene	IL1RN	C0018099	Gout	1	CTD_human
Hgene	IL1RN	C0021368	Inflammation	1	CTD_human
Hgene	IL1RN	C0022658	Kidney Diseases	1	CTD_human
Hgene	IL1RN	C0023186	Learning Disorders	1	CTD_human
Hgene	IL1RN	C0026769	Multiple Sclerosis	1	CTD_human
Hgene	IL1RN	C0027121	Myositis	1	CTD_human
Hgene	IL1RN	C0027626	Neoplasm Invasiveness	1	CTD_human
Hgene	IL1RN	C0030193	Pain	1	CTD_human
Hgene	IL1RN	C0033687	Proteinuria	1	CTD_human
Hgene	IL1RN	C0034069	Pulmonary Fibrosis	1	CTD_human
Hgene	IL1RN	C0035021	Relapsing Fever	1	GENOMICS_ENGLAND
Hgene	IL1RN	C0036429	Sclerosis	1	CTD_human
Hgene	IL1RN	C0038220	Status Epilepticus	1	CTD_human
Hgene	IL1RN	C0038454	Cerebrovascular accident	1	CTD_human
Hgene	IL1RN	C0085129	Bronchial Hyperreactivity	1	CTD_human
Hgene	IL1RN	C0087031	Juvenile-Onset Still Disease	1	CTD_human
Hgene	IL1RN	C0158353	Infectious Myositis	1	CTD_human
Hgene	IL1RN	C0162557	Liver Failure, Acute	1	CTD_human
Hgene	IL1RN	C0234230	Pain, Burning	1	CTD_human
Hgene	IL1RN	C0234238	Ache	1	CTD_human
Hgene	IL1RN	C0234254	Radiating pain	1	CTD_human
Hgene	IL1RN	C0270823	Petit mal status	1	CTD_human
Hgene	IL1RN	C0274861	Arsenic Poisoning, Inorganic	1	CTD_human
Hgene	IL1RN	C0274862	Nervous System, Organic Arsenic Poisoning	1	CTD_human
Hgene	IL1RN	C0311335	Grand Mal Status Epilepticus	1	CTD_human
Hgene	IL1RN	C0311375	Arsenic Poisoning	1	CTD_human
Hgene	IL1RN	C0333355	Inflammatory disease of mucous membrane	1	CTD_human
Hgene	IL1RN	C0333641	Atrophic	1	CTD_human
Hgene	IL1RN	C0393734	Complex Partial Status Epilepticus	1	CTD_human
Hgene	IL1RN	C0458257	Pain, Splitting	1	CTD_human
Hgene	IL1RN	C0458259	Pain, Crushing	1	CTD_human
Hgene	IL1RN	C0524988	Schnitzler Syndrome	1	CTD_human
Hgene	IL1RN	C0544796	Myositis, Proliferative	1	CTD_human
Hgene	IL1RN	C0751262	Adult Learning Disorders	1	CTD_human
Hgene	IL1RN	C0751263	Learning Disturbance	1	CTD_human
Hgene	IL1RN	C0751265	Learning Disabilities	1	CTD_human
Hgene	IL1RN	C0751324	Multiple Sclerosis, Acute Fulminating	1	CTD_human
Hgene	IL1RN	C0751356	Idiopathic Inflammatory Myopathies	1	CTD_human
Hgene	IL1RN	C0751357	Myositis, Focal	1	CTD_human
Hgene	IL1RN	C0751407	Pain, Migratory	1	CTD_human
Hgene	IL1RN	C0751408	Suffering, Physical	1	CTD_human
Hgene	IL1RN	C0751522	Status Epilepticus, Subclinical	1	CTD_human
Hgene	IL1RN	C0751523	Non-Convulsive Status Epilepticus	1	CTD_human
Hgene	IL1RN	C0751524	Simple Partial Status Epilepticus	1	CTD_human
Hgene	IL1RN	C0751851	Arsenic Encephalopathy	1	CTD_human
Hgene	IL1RN	C0751852	Arsenic Induced Polyneuropathy	1	CTD_human
Hgene	IL1RN	C0751956	Acute Cerebrovascular Accidents	1	CTD_human
Hgene	IL1RN	C0917798	Cerebral Ischemia	1	CTD_human
Hgene	IL1RN	C1330966	Developmental Academic Disorder	1	CTD_human
Hgene	IL1RN	C1623038	Cirrhosis	1	CTD_human
Hgene	IL1RN	C2239176	Liver carcinoma	1	CTD_human
Hgene	IL1RN	C3495559	Juvenile arthritis	1	CTD_human
Hgene	IL1RN	C3714758	Juvenile psoriatic arthritis	1	CTD_human
Hgene	IL1RN	C3714772	Recurrent fevers	1	GENOMICS_ENGLAND
Hgene	IL1RN	C3860213	Autoinflammatory disorder	1	GENOMICS_ENGLAND
Hgene	IL1RN	C4552091	Polyarthritis, Juvenile, Rheumatoid Factor Negative	1	CTD_human
Hgene	IL1RN	C4704862	Polyarthritis, Juvenile, Rheumatoid Factor Positive	1	CTD_human
Hgene	IL1RN	C4721507	Alveolitis, Fibrosing	1	CTD_human
Tgene		C0036341	Schizophrenia	2	PSYGENET
Tgene		C1858266	Bare Lymphocyte Syndrome, Type I	2	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene		C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene		C1868476	Wegener-Like Granulomatosis	1	GENOMICS_ENGLAND

Fusion Gene Studies in Kim Lab

Fusion gene:IL1RN-TAP2 (FusionGDB2 ID:HG3557TG6891)

Fusion Gene Summary for IL1RN-TAP2

Fusion Gene ORF analysis for IL1RN-TAP2

Fusion Genomic Features for IL1RN-TAP2

Fusion Protein Features for IL1RN-TAP2

Fusion Gene Sequence for IL1RN-TAP2

Fusion Gene PPI Analysis for IL1RN-TAP2

Related Drugs for IL1RN-TAP2

Related Diseases for IL1RN-TAP2

Fusion Gene Studies
in Kim Lab