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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:IL7R-LRPPRC (FusionGDB2 ID:HG3575TG10128) |
Fusion Gene Summary for IL7R-LRPPRC |
Fusion gene summary |
Fusion gene information | Fusion gene name: IL7R-LRPPRC | Fusion gene ID: hg3575tg10128 | Hgene | Tgene | Gene symbol | IL7R | LRPPRC | Gene ID | 3575 | 10128 |
Gene name | interleukin 7 receptor | leucine rich pentatricopeptide repeat containing | |
Synonyms | CD127|CDW127|IL-7R-alpha|IL7RA|ILRA | CLONE-23970|GP130|LRP130|LSFC | |
Cytomap | ('IL7R')('LRPPRC') 5p13.2 | 2p21 | |
Type of gene | protein-coding | protein-coding | |
Description | interleukin-7 receptor subunit alphaCD127 antigenIL-7 receptor subunit alphaIL-7R subunit alphainterleukin 7 receptor alpha chaininterleukin 7 receptor isoform H5-6 | leucine-rich PPR motif-containing protein, mitochondrial130 kDa leucine-rich proteinLRP 130leucine-rich PPR-motif containingmitochondrial leucine-rich PPR motif-containing protein | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | P16871 | . | |
Ensembl transtripts involved in fusion gene | ENST00000303115, ENST00000343305, ENST00000506850, ENST00000511031, ENST00000511982, | ||
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 13 X 13 X 4=676 |
# samples | 1 | 13 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(13/676*10)=-2.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: IL7R [Title/Abstract] AND LRPPRC [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | IL7R(35867565)-LRPPRC(44171033), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | IL7R-LRPPRC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. IL7R-LRPPRC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. IL7R-LRPPRC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. IL7R-LRPPRC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. IL7R-LRPPRC seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. IL7R-LRPPRC seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. IL7R-LRPPRC seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | IL7R | GO:0008284 | positive regulation of cell proliferation | 11418668 |
Hgene | IL7R | GO:1904894 | positive regulation of STAT cascade | 11418668 |
Fusion gene breakpoints across IL7R (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across LRPPRC (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-HU-A4GY-01A | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - |
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Fusion Gene ORF analysis for IL7R-LRPPRC |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000303115 | ENST00000409659 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - |
5CDS-intron | ENST00000303115 | ENST00000409946 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - |
5CDS-intron | ENST00000343305 | ENST00000409659 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - |
5CDS-intron | ENST00000343305 | ENST00000409946 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - |
5CDS-intron | ENST00000506850 | ENST00000409659 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - |
5CDS-intron | ENST00000506850 | ENST00000409946 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - |
5CDS-intron | ENST00000511031 | ENST00000409659 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - |
5CDS-intron | ENST00000511031 | ENST00000409946 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - |
5CDS-intron | ENST00000511982 | ENST00000409659 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - |
5CDS-intron | ENST00000511982 | ENST00000409946 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - |
Frame-shift | ENST00000511031 | ENST00000260665 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - |
In-frame | ENST00000303115 | ENST00000260665 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - |
In-frame | ENST00000343305 | ENST00000260665 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - |
In-frame | ENST00000506850 | ENST00000260665 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - |
In-frame | ENST00000511982 | ENST00000260665 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000303115 | IL7R | chr5 | 35867565 | + | ENST00000260665 | LRPPRC | chr2 | 44171033 | - | 4489 | 508 | 129 | 2396 | 755 |
ENST00000343305 | IL7R | chr5 | 35867565 | + | ENST00000260665 | LRPPRC | chr2 | 44171033 | - | 4449 | 468 | 89 | 2356 | 755 |
ENST00000506850 | IL7R | chr5 | 35867565 | + | ENST00000260665 | LRPPRC | chr2 | 44171033 | - | 4447 | 466 | 87 | 2354 | 755 |
ENST00000511982 | IL7R | chr5 | 35867565 | + | ENST00000260665 | LRPPRC | chr2 | 44171033 | - | 4435 | 454 | 468 | 2342 | 624 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000303115 | ENST00000260665 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - | 0.001016118 | 0.9989839 |
ENST00000343305 | ENST00000260665 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - | 0.001036558 | 0.9989635 |
ENST00000506850 | ENST00000260665 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - | 0.001040987 | 0.99895895 |
ENST00000511982 | ENST00000260665 | IL7R | chr5 | 35867565 | + | LRPPRC | chr2 | 44171033 | - | 0.000164229 | 0.9998357 |
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Fusion Genomic Features for IL7R-LRPPRC |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for IL7R-LRPPRC |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:35867565/chr2:44171033) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
IL7R | . |
FUNCTION: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 1121_1394 | 765 | 1395.0 | Region | Note=RNA-binding | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 1121_1394 | 0 | 532.0 | Region | Note=RNA-binding | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 1031_1065 | 765 | 1395.0 | Repeat | Note=PPR 15 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 1066_1102 | 765 | 1395.0 | Repeat | Note=PPR 16 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 1103_1137 | 765 | 1395.0 | Repeat | Note=PPR 17 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 1138_1175 | 765 | 1395.0 | Repeat | Note=PPR 18 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 1176_1210 | 765 | 1395.0 | Repeat | Note=PPR 19 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 1317_1351 | 765 | 1395.0 | Repeat | Note=PPR 20 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 785_820 | 765 | 1395.0 | Repeat | Note=PPR 12 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 821_856 | 765 | 1395.0 | Repeat | Note=PPR 13 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 954_988 | 765 | 1395.0 | Repeat | Note=PPR 14 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 1031_1065 | 0 | 532.0 | Repeat | Note=PPR 15 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 1066_1102 | 0 | 532.0 | Repeat | Note=PPR 16 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 1103_1137 | 0 | 532.0 | Repeat | Note=PPR 17 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 1138_1175 | 0 | 532.0 | Repeat | Note=PPR 18 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 1176_1210 | 0 | 532.0 | Repeat | Note=PPR 19 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 126_160 | 0 | 532.0 | Repeat | Note=PPR 1 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 1317_1351 | 0 | 532.0 | Repeat | Note=PPR 20 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 161_195 | 0 | 532.0 | Repeat | Note=PPR 2 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 196_230 | 0 | 532.0 | Repeat | Note=PPR 3 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 231_265 | 0 | 532.0 | Repeat | Note=PPR 4 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 266_300 | 0 | 532.0 | Repeat | Note=PPR 5 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 301_335 | 0 | 532.0 | Repeat | Note=PPR 6 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 403_437 | 0 | 532.0 | Repeat | Note=PPR 7 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 438_472 | 0 | 532.0 | Repeat | Note=PPR 8 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 678_709 | 0 | 532.0 | Repeat | Note=PPR 9 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 710_746 | 0 | 532.0 | Repeat | Note=PPR 10 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 747_784 | 0 | 532.0 | Repeat | Note=PPR 11 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 785_820 | 0 | 532.0 | Repeat | Note=PPR 12 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 821_856 | 0 | 532.0 | Repeat | Note=PPR 13 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000409946 | 0 | 14 | 954_988 | 0 | 532.0 | Repeat | Note=PPR 14 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | IL7R | chr5:35867565 | chr2:44171033 | ENST00000303115 | + | 3 | 8 | 184_189 | 126 | 460.0 | Compositional bias | Note=Ser/Thr-rich |
Hgene | IL7R | chr5:35867565 | chr2:44171033 | ENST00000303115 | + | 3 | 8 | 131_231 | 126 | 460.0 | Domain | Fibronectin type-III |
Hgene | IL7R | chr5:35867565 | chr2:44171033 | ENST00000303115 | + | 3 | 8 | 217_221 | 126 | 460.0 | Motif | Note=WSXWS motif |
Hgene | IL7R | chr5:35867565 | chr2:44171033 | ENST00000303115 | + | 3 | 8 | 272_280 | 126 | 460.0 | Motif | Note=Box 1 motif |
Hgene | IL7R | chr5:35867565 | chr2:44171033 | ENST00000303115 | + | 3 | 8 | 21_239 | 126 | 460.0 | Topological domain | Extracellular |
Hgene | IL7R | chr5:35867565 | chr2:44171033 | ENST00000303115 | + | 3 | 8 | 265_459 | 126 | 460.0 | Topological domain | Cytoplasmic |
Hgene | IL7R | chr5:35867565 | chr2:44171033 | ENST00000303115 | + | 3 | 8 | 240_264 | 126 | 460.0 | Transmembrane | Helical |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 126_160 | 765 | 1395.0 | Repeat | Note=PPR 1 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 161_195 | 765 | 1395.0 | Repeat | Note=PPR 2 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 196_230 | 765 | 1395.0 | Repeat | Note=PPR 3 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 231_265 | 765 | 1395.0 | Repeat | Note=PPR 4 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 266_300 | 765 | 1395.0 | Repeat | Note=PPR 5 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 301_335 | 765 | 1395.0 | Repeat | Note=PPR 6 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 403_437 | 765 | 1395.0 | Repeat | Note=PPR 7 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 438_472 | 765 | 1395.0 | Repeat | Note=PPR 8 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 678_709 | 765 | 1395.0 | Repeat | Note=PPR 9 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 710_746 | 765 | 1395.0 | Repeat | Note=PPR 10 | |
Tgene | LRPPRC | chr5:35867565 | chr2:44171033 | ENST00000260665 | 21 | 38 | 747_784 | 765 | 1395.0 | Repeat | Note=PPR 11 |
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Fusion Gene Sequence for IL7R-LRPPRC |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>39599_39599_1_IL7R-LRPPRC_IL7R_chr5_35867565_ENST00000303115_LRPPRC_chr2_44171033_ENST00000260665_length(transcript)=4489nt_BP=508nt GTGGTTAGATAAGTATAAAGCCCTAGATCTAAGCTTCTCTGTCTTCCTCCCTCCCTCCCTTCCTCTTACTCTCATTCATTTCATACACAC TGGCTCACACATCTACTCTCTCTCTCTATCTCTCTCAGAATGACAATTCTAGGTACAACTTTTGGCATGGTTTTTTCTTTACTTCAAGTC GTTTCTGGAGAAAGTGGCTATGCTCAAAATGGAGACTTGGAAGATGCAGAACTGGATGACTACTCATTCTCATGCTATAGCCAGTTGGAA GTGAATGGATCGCAGCACTCACTGACCTGTGCTTTTGAGGACCCAGATGTCAACATCACCAATCTGGAATTTGAAATATGTGGGGCCCTC GTGGAGGTAAAGTGCCTGAATTTCAGGAAACTACAAGAGATATATTTCATCGAGACAAAGAAATTCTTACTGATTGGAAAGAGCAATATA TGTGTGAAGGTTGGAGAAAAGAGTCTAACCTGCAAAAAAATAGACCTAACCACTATAGATGCTATTAACATTCTGAAGGAGATGAAAGAG AAGGATGTTCTTATCAAAGATACAACAGCCTTGTCCTTTTTCCACATGCTAAATGGCGCAGCTTTAAGAGGTGAAATTGAAACAGTAAAA CAGTTGCATGAAGCCATCGTGACTCTAGGGTTAGCAGAACCATCCACCAACATAAGTTTCCCATTGGTCACTGTACACTTGGAAAAGGGC GACCTATCTACTGCTCTTGAGGTCGCCATTGACTGCTATGAAAAGTATAAAGTATTACCAAGGATTCATGATGTCTTGTGTAAACTGGTA GAGAAAGGCGAGACTGATCTAATTCAGAAAGCAATGGACTTTGTGAGCCAAGAACAAGGTGAAATGGTGATGCTCTATGATCTCTTCTTT GCCTTCCTACAAACAGGAAATTACAAAGAGGCCAAGAAGATCATTGAGACTCCAGGGATTAGAGCTCGATCTGCAAGGCTTCAGTGGTTT TGTGACAGATGTGTTGCAAATAATCAGGTTGAAACTCTGGAAAAATTAGTGGAGCTGACACAGAAGCTATTTGAATGTGATAGAGACCAG ATGTACTACAATCTGCTAAAACTGTATAAAATAAACGGTGACTGGCAAAGAGCTGATGCAGTCTGGAATAAAATCCAAGAAGAAAATGTT ATTCCTCGTGAAAAGACATTAAGATTATTAGCAGAAATCCTTAGAGAGGGTAACCAGGAAGTTCCGTTTGACGTACCTGAGTTGTGGTAT GAAGATGAAAAACATTCCCTGAATTCTTCGTCAGCCTCAACCACAGAACCTGATTTCCAGAAAGATATATTGATTGCCTGCCGATTGAAC CAAAAAAAAGGGGCATATGATATTTTCCTGAATGCAAAAGAGCAAAACATTGTGTTTAATGCTGAAACCTACAGCAATCTCATTAAATTA CTGATGTCAGAAGATTATTTTACACAAGCAATGGAAGTGAAAGCATTCGCGGAGACCCACATCAAGGGCTTCACACTGAACGATGCTGCC AACAGCCGCCTCATCATAACGCAAGTTAGGCGGGATTATTTGAAAGAGGCTGTGACAACACTGAAAACAGTATTGGATCAGCAGCAGACC CCTTCTAGGTTAGCAGTGACCCGTGTCATCCAGGCATTGGCCATGAAGGGTGATGTTGAAAACATAGAAGTAGTTCAGAAGATGTTAAAT GGACTCGAAGACTCCATTGGACTTTCAAAAATGGTTTTCATCAATAACATTGCTTTGGCTCAAATAAAGAATAATAACATAGATGCCGCA ATAGAAAACATTGAAAATATGCTTACTTCAGAGAATAAAGTCATTGAACCCCAATACTTCGGCTTGGCATACTTATTCAGAAAAGTAATA GAGGAGCAGTTGGAACCAGCAGTTGAAAAGATAAGCATCATGGCGGAGAGATTGGCCAATCAGTTTGCAATTTATAAACCTGTCACTGAT TTTTTCCTTCAACTTGTGGATGCAGGCAAGGTGGATGATGCCAGAGCTCTCCTACAGAGATGTGGTGCAATTGCTGAACAAACCCCGATT TTGTTGTTGTTCCTCCTTAGGAATTCTAGGAAACAAGGAAAGGCATCAACTGTGAAATCTGTGTTAGAATTGATTCCTGAATTAAATGAA AAGGAAGAAGCATACAATTCCCTCATGAAAAGCTATGTCTCAGAGAAAGATGTCACATCTGCTAAAGCACTGTATGAACATTTGACTGCA AAGAATACAAAATTGGATGATCTGTTTCTAAAGCGTTACGCATCTTTGCTGAAGTATGCTGGAGAGCCTGTCCCTTTCATTGAACCCCCT GAAAGCTTTGAATTTTATGCACAGCAGCTAAGAAAATTGAGGGAAAACTCTTCTTGAAATAACCAGGCGATACTTTGTTTTGTATATATT TGTGATTCTGTGTCTACATGTTATTTTGAAGTATATCTGAGGGAAAAATAAATGAAAATTTTCTTTATGTACTTATGTATGTGTGATGCA TGTTCAAAGTCTTATTGACCATAACTCTGTGCACTTGGTTATTGGACATTTTTGGAGTTTTTTTCTCTGGGAAAAATCGATAGTGTTTTC TTCAATGCTGCTGCTGTGTGAAGCCATACTTTTTCAGGATTCTTCCCCTAATTGGCTCTTTGGTTTCCCTGCTCTGTTTCATTTATTTCA TTAAAATGTTATTCCTTTATTTAAGATTCACTTATTAGTCTGCTGTTTCTCTGAAAAATTTTAGAGCTAGGTATAGTGACCGTGAACTTT CTAACGCATAATATTCTGTGATACAGCCATTCCGTACATGTGTGAAGTCCTGCATAACTTTCGAACTTTGTTAAATGTTGGCACTAGGAG TCATCAGATCTAGGCTTCATCATTTTCCAGTGAGAAGCAGAGACCCAAAGGGCCTGTTACTTGTGCTTGGTCAGGGGACTGTCTGTCATG CCTGGAGGCTCTTCGGCACACTTCCCCATCTTTCCCTTCTGCCACTGTGGCTTCAAGCACCTCTGTTCATAGAGCGTCTCTGAAATTGAG TCTCGGTCATGACTTATCCCGAAGTAGAGCAATGTGTTTCCTCTCATTGTAGTTTCAGGACTTTGTCAGTACAAGCTCTGCCCTAGGCTT GTTACTTTATACTCATATCCTGAAAAGATGTGATTTCATCTATGAAGGGGTAAAATATTGGTTTGTATTTAATTGTTTGAAATAAAAGTG ATCCCTATATTGAATCTCATGCCTGTTAATATCTACACTGTAAGTAGTGACTTCAAAAAAATTCTAAGATAGGTAGTCAGGAGAGTTTGC CATTATAAAAGGTGTCTTAATAATATGGAATATTGACCTAACTGGAGATGAGGTAATTAATTACCGAAATGTTGAAAATGTTTTGAGAAC TCTCCCCATTTTGGGGTATTCCTTGTTCATTTGAATTTGGTGACTCCCTACTGTTCCAGTTTCAGTGCCAACTTGGGTCACACTGTTCAC ATCAGGGGAGACCTTGCCTTGGGGACGTAGGCGGGCCTCTTGCAACTTGTGCTGTTGACCTTCTGTCTTGTGGAACTCTCTCTCCTGCAT CTGCTACCTGCCCGCAGATGGTGTGAGGGAGGGTTGATGGCGGGAAGCCAGGAAGTAGATGTCATCATGGTATTGGCCAGGCTTTTACTT CAACTCTTTTTGTGGCGTTAGATTTAAGGAAGCAGGGGGCATGGCCAACGTTGAGTCTTGGCCCAGTGGACATAGTGCGGCTTTCCCTTG AGCACTGCCCAGATGCAGGACCTGCACATGTTACAGGTTTGCCAAAAGCATCTTTTTTTTTTTTTTTTTTTTTGAGATAGTCTTGCTCTG TTGCTTAAGCCAGAGTGCAGTGGCGCAATCTCAGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTTGTGCCTCAGCCTCCCAC GTAGCTGAGATTACAGGCTTGCACCACCATGTTCAGCTAATTTTTGTATGGTAAAGACGGAGTTTCACCATGTTGGCCAGGTTGGTCTCG AACTCCTGGCCCCAAGTGATCCTCCCCCTGCGCTCGCTTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCTGGCCAA GAGCCTCACTCCTGTCTTTAGTGATTGCACTGAAGCAGGCCTCATTTTTTTGCAGTCATGCTAACCACAAGTTAGTCAACATTCACTAAT TGACATTCATTAGAATAGGTCTCCAAGGTGAGGCATAACGTTGGGGTGTAATCTGGATTTCGCAGTCATCTTTTTGGGGAAACTGAAAGT ACCATCTCATTTGCATGAAGTGACTCCACACTGGCCCTGTATATGGACTCTGGTAAAATGTGAGTGTGGTACAGAGGAAATAGGTAAGAC >39599_39599_1_IL7R-LRPPRC_IL7R_chr5_35867565_ENST00000303115_LRPPRC_chr2_44171033_ENST00000260665_length(amino acids)=755AA_BP=126 MTILGTTFGMVFSLLQVVSGESGYAQNGDLEDAELDDYSFSCYSQLEVNGSQHSLTCAFEDPDVNITNLEFEICGALVEVKCLNFRKLQE IYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIDAINILKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAE PSTNISFPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKK IIETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEI LREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEV KAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVF INNIALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDD ARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRY -------------------------------------------------------------- >39599_39599_2_IL7R-LRPPRC_IL7R_chr5_35867565_ENST00000343305_LRPPRC_chr2_44171033_ENST00000260665_length(transcript)=4449nt_BP=468nt GTCTTCCTCCCTCCCTCCCTTCCTCTTACTCTCATTCATTTCATACACACTGGCTCACACATCTACTCTCTCTCTCTATCTCTCTCAGAA TGACAATTCTAGGTACAACTTTTGGCATGGTTTTTTCTTTACTTCAAGTCGTTTCTGGAGAAAGTGGCTATGCTCAAAATGGAGACTTGG AAGATGCAGAACTGGATGACTACTCATTCTCATGCTATAGCCAGTTGGAAGTGAATGGATCGCAGCACTCACTGACCTGTGCTTTTGAGG ACCCAGATGTCAACATCACCAATCTGGAATTTGAAATATGTGGGGCCCTCGTGGAGGTAAAGTGCCTGAATTTCAGGAAACTACAAGAGA TATATTTCATCGAGACAAAGAAATTCTTACTGATTGGAAAGAGCAATATATGTGTGAAGGTTGGAGAAAAGAGTCTAACCTGCAAAAAAA TAGACCTAACCACTATAGATGCTATTAACATTCTGAAGGAGATGAAAGAGAAGGATGTTCTTATCAAAGATACAACAGCCTTGTCCTTTT TCCACATGCTAAATGGCGCAGCTTTAAGAGGTGAAATTGAAACAGTAAAACAGTTGCATGAAGCCATCGTGACTCTAGGGTTAGCAGAAC CATCCACCAACATAAGTTTCCCATTGGTCACTGTACACTTGGAAAAGGGCGACCTATCTACTGCTCTTGAGGTCGCCATTGACTGCTATG AAAAGTATAAAGTATTACCAAGGATTCATGATGTCTTGTGTAAACTGGTAGAGAAAGGCGAGACTGATCTAATTCAGAAAGCAATGGACT TTGTGAGCCAAGAACAAGGTGAAATGGTGATGCTCTATGATCTCTTCTTTGCCTTCCTACAAACAGGAAATTACAAAGAGGCCAAGAAGA TCATTGAGACTCCAGGGATTAGAGCTCGATCTGCAAGGCTTCAGTGGTTTTGTGACAGATGTGTTGCAAATAATCAGGTTGAAACTCTGG AAAAATTAGTGGAGCTGACACAGAAGCTATTTGAATGTGATAGAGACCAGATGTACTACAATCTGCTAAAACTGTATAAAATAAACGGTG ACTGGCAAAGAGCTGATGCAGTCTGGAATAAAATCCAAGAAGAAAATGTTATTCCTCGTGAAAAGACATTAAGATTATTAGCAGAAATCC TTAGAGAGGGTAACCAGGAAGTTCCGTTTGACGTACCTGAGTTGTGGTATGAAGATGAAAAACATTCCCTGAATTCTTCGTCAGCCTCAA CCACAGAACCTGATTTCCAGAAAGATATATTGATTGCCTGCCGATTGAACCAAAAAAAAGGGGCATATGATATTTTCCTGAATGCAAAAG AGCAAAACATTGTGTTTAATGCTGAAACCTACAGCAATCTCATTAAATTACTGATGTCAGAAGATTATTTTACACAAGCAATGGAAGTGA AAGCATTCGCGGAGACCCACATCAAGGGCTTCACACTGAACGATGCTGCCAACAGCCGCCTCATCATAACGCAAGTTAGGCGGGATTATT TGAAAGAGGCTGTGACAACACTGAAAACAGTATTGGATCAGCAGCAGACCCCTTCTAGGTTAGCAGTGACCCGTGTCATCCAGGCATTGG CCATGAAGGGTGATGTTGAAAACATAGAAGTAGTTCAGAAGATGTTAAATGGACTCGAAGACTCCATTGGACTTTCAAAAATGGTTTTCA TCAATAACATTGCTTTGGCTCAAATAAAGAATAATAACATAGATGCCGCAATAGAAAACATTGAAAATATGCTTACTTCAGAGAATAAAG TCATTGAACCCCAATACTTCGGCTTGGCATACTTATTCAGAAAAGTAATAGAGGAGCAGTTGGAACCAGCAGTTGAAAAGATAAGCATCA TGGCGGAGAGATTGGCCAATCAGTTTGCAATTTATAAACCTGTCACTGATTTTTTCCTTCAACTTGTGGATGCAGGCAAGGTGGATGATG CCAGAGCTCTCCTACAGAGATGTGGTGCAATTGCTGAACAAACCCCGATTTTGTTGTTGTTCCTCCTTAGGAATTCTAGGAAACAAGGAA AGGCATCAACTGTGAAATCTGTGTTAGAATTGATTCCTGAATTAAATGAAAAGGAAGAAGCATACAATTCCCTCATGAAAAGCTATGTCT CAGAGAAAGATGTCACATCTGCTAAAGCACTGTATGAACATTTGACTGCAAAGAATACAAAATTGGATGATCTGTTTCTAAAGCGTTACG CATCTTTGCTGAAGTATGCTGGAGAGCCTGTCCCTTTCATTGAACCCCCTGAAAGCTTTGAATTTTATGCACAGCAGCTAAGAAAATTGA GGGAAAACTCTTCTTGAAATAACCAGGCGATACTTTGTTTTGTATATATTTGTGATTCTGTGTCTACATGTTATTTTGAAGTATATCTGA GGGAAAAATAAATGAAAATTTTCTTTATGTACTTATGTATGTGTGATGCATGTTCAAAGTCTTATTGACCATAACTCTGTGCACTTGGTT ATTGGACATTTTTGGAGTTTTTTTCTCTGGGAAAAATCGATAGTGTTTTCTTCAATGCTGCTGCTGTGTGAAGCCATACTTTTTCAGGAT TCTTCCCCTAATTGGCTCTTTGGTTTCCCTGCTCTGTTTCATTTATTTCATTAAAATGTTATTCCTTTATTTAAGATTCACTTATTAGTC TGCTGTTTCTCTGAAAAATTTTAGAGCTAGGTATAGTGACCGTGAACTTTCTAACGCATAATATTCTGTGATACAGCCATTCCGTACATG TGTGAAGTCCTGCATAACTTTCGAACTTTGTTAAATGTTGGCACTAGGAGTCATCAGATCTAGGCTTCATCATTTTCCAGTGAGAAGCAG AGACCCAAAGGGCCTGTTACTTGTGCTTGGTCAGGGGACTGTCTGTCATGCCTGGAGGCTCTTCGGCACACTTCCCCATCTTTCCCTTCT GCCACTGTGGCTTCAAGCACCTCTGTTCATAGAGCGTCTCTGAAATTGAGTCTCGGTCATGACTTATCCCGAAGTAGAGCAATGTGTTTC CTCTCATTGTAGTTTCAGGACTTTGTCAGTACAAGCTCTGCCCTAGGCTTGTTACTTTATACTCATATCCTGAAAAGATGTGATTTCATC TATGAAGGGGTAAAATATTGGTTTGTATTTAATTGTTTGAAATAAAAGTGATCCCTATATTGAATCTCATGCCTGTTAATATCTACACTG TAAGTAGTGACTTCAAAAAAATTCTAAGATAGGTAGTCAGGAGAGTTTGCCATTATAAAAGGTGTCTTAATAATATGGAATATTGACCTA ACTGGAGATGAGGTAATTAATTACCGAAATGTTGAAAATGTTTTGAGAACTCTCCCCATTTTGGGGTATTCCTTGTTCATTTGAATTTGG TGACTCCCTACTGTTCCAGTTTCAGTGCCAACTTGGGTCACACTGTTCACATCAGGGGAGACCTTGCCTTGGGGACGTAGGCGGGCCTCT TGCAACTTGTGCTGTTGACCTTCTGTCTTGTGGAACTCTCTCTCCTGCATCTGCTACCTGCCCGCAGATGGTGTGAGGGAGGGTTGATGG CGGGAAGCCAGGAAGTAGATGTCATCATGGTATTGGCCAGGCTTTTACTTCAACTCTTTTTGTGGCGTTAGATTTAAGGAAGCAGGGGGC ATGGCCAACGTTGAGTCTTGGCCCAGTGGACATAGTGCGGCTTTCCCTTGAGCACTGCCCAGATGCAGGACCTGCACATGTTACAGGTTT GCCAAAAGCATCTTTTTTTTTTTTTTTTTTTTTGAGATAGTCTTGCTCTGTTGCTTAAGCCAGAGTGCAGTGGCGCAATCTCAGCTCACT GCAACCTCCGCCTCCTGGGTTCAAGTGATTCTTGTGCCTCAGCCTCCCACGTAGCTGAGATTACAGGCTTGCACCACCATGTTCAGCTAA TTTTTGTATGGTAAAGACGGAGTTTCACCATGTTGGCCAGGTTGGTCTCGAACTCCTGGCCCCAAGTGATCCTCCCCCTGCGCTCGCTTC AGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCTGGCCAAGAGCCTCACTCCTGTCTTTAGTGATTGCACTGAAGCAGGC CTCATTTTTTTGCAGTCATGCTAACCACAAGTTAGTCAACATTCACTAATTGACATTCATTAGAATAGGTCTCCAAGGTGAGGCATAACG TTGGGGTGTAATCTGGATTTCGCAGTCATCTTTTTGGGGAAACTGAAAGTACCATCTCATTTGCATGAAGTGACTCCACACTGGCCCTGT ATATGGACTCTGGTAAAATGTGAGTGTGGTACAGAGGAAATAGGTAAGACCCCCTTATCTAGCCCTCTCGGCAGCAGCGGGGGGGTGTTA >39599_39599_2_IL7R-LRPPRC_IL7R_chr5_35867565_ENST00000343305_LRPPRC_chr2_44171033_ENST00000260665_length(amino acids)=755AA_BP=126 MTILGTTFGMVFSLLQVVSGESGYAQNGDLEDAELDDYSFSCYSQLEVNGSQHSLTCAFEDPDVNITNLEFEICGALVEVKCLNFRKLQE IYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIDAINILKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAE PSTNISFPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKK IIETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEI LREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEV KAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVF INNIALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDD ARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRY -------------------------------------------------------------- >39599_39599_3_IL7R-LRPPRC_IL7R_chr5_35867565_ENST00000506850_LRPPRC_chr2_44171033_ENST00000260665_length(transcript)=4447nt_BP=466nt CTTCCTCCCTCCCTCCCTTCCTCTTACTCTCATTCATTTCATACACACTGGCTCACACATCTACTCTCTCTCTCTATCTCTCTCAGAATG ACAATTCTAGGTACAACTTTTGGCATGGTTTTTTCTTTACTTCAAGTCGTTTCTGGAGAAAGTGGCTATGCTCAAAATGGAGACTTGGAA GATGCAGAACTGGATGACTACTCATTCTCATGCTATAGCCAGTTGGAAGTGAATGGATCGCAGCACTCACTGACCTGTGCTTTTGAGGAC CCAGATGTCAACATCACCAATCTGGAATTTGAAATATGTGGGGCCCTCGTGGAGGTAAAGTGCCTGAATTTCAGGAAACTACAAGAGATA TATTTCATCGAGACAAAGAAATTCTTACTGATTGGAAAGAGCAATATATGTGTGAAGGTTGGAGAAAAGAGTCTAACCTGCAAAAAAATA GACCTAACCACTATAGATGCTATTAACATTCTGAAGGAGATGAAAGAGAAGGATGTTCTTATCAAAGATACAACAGCCTTGTCCTTTTTC CACATGCTAAATGGCGCAGCTTTAAGAGGTGAAATTGAAACAGTAAAACAGTTGCATGAAGCCATCGTGACTCTAGGGTTAGCAGAACCA TCCACCAACATAAGTTTCCCATTGGTCACTGTACACTTGGAAAAGGGCGACCTATCTACTGCTCTTGAGGTCGCCATTGACTGCTATGAA AAGTATAAAGTATTACCAAGGATTCATGATGTCTTGTGTAAACTGGTAGAGAAAGGCGAGACTGATCTAATTCAGAAAGCAATGGACTTT GTGAGCCAAGAACAAGGTGAAATGGTGATGCTCTATGATCTCTTCTTTGCCTTCCTACAAACAGGAAATTACAAAGAGGCCAAGAAGATC ATTGAGACTCCAGGGATTAGAGCTCGATCTGCAAGGCTTCAGTGGTTTTGTGACAGATGTGTTGCAAATAATCAGGTTGAAACTCTGGAA AAATTAGTGGAGCTGACACAGAAGCTATTTGAATGTGATAGAGACCAGATGTACTACAATCTGCTAAAACTGTATAAAATAAACGGTGAC TGGCAAAGAGCTGATGCAGTCTGGAATAAAATCCAAGAAGAAAATGTTATTCCTCGTGAAAAGACATTAAGATTATTAGCAGAAATCCTT AGAGAGGGTAACCAGGAAGTTCCGTTTGACGTACCTGAGTTGTGGTATGAAGATGAAAAACATTCCCTGAATTCTTCGTCAGCCTCAACC ACAGAACCTGATTTCCAGAAAGATATATTGATTGCCTGCCGATTGAACCAAAAAAAAGGGGCATATGATATTTTCCTGAATGCAAAAGAG CAAAACATTGTGTTTAATGCTGAAACCTACAGCAATCTCATTAAATTACTGATGTCAGAAGATTATTTTACACAAGCAATGGAAGTGAAA GCATTCGCGGAGACCCACATCAAGGGCTTCACACTGAACGATGCTGCCAACAGCCGCCTCATCATAACGCAAGTTAGGCGGGATTATTTG AAAGAGGCTGTGACAACACTGAAAACAGTATTGGATCAGCAGCAGACCCCTTCTAGGTTAGCAGTGACCCGTGTCATCCAGGCATTGGCC ATGAAGGGTGATGTTGAAAACATAGAAGTAGTTCAGAAGATGTTAAATGGACTCGAAGACTCCATTGGACTTTCAAAAATGGTTTTCATC AATAACATTGCTTTGGCTCAAATAAAGAATAATAACATAGATGCCGCAATAGAAAACATTGAAAATATGCTTACTTCAGAGAATAAAGTC ATTGAACCCCAATACTTCGGCTTGGCATACTTATTCAGAAAAGTAATAGAGGAGCAGTTGGAACCAGCAGTTGAAAAGATAAGCATCATG GCGGAGAGATTGGCCAATCAGTTTGCAATTTATAAACCTGTCACTGATTTTTTCCTTCAACTTGTGGATGCAGGCAAGGTGGATGATGCC AGAGCTCTCCTACAGAGATGTGGTGCAATTGCTGAACAAACCCCGATTTTGTTGTTGTTCCTCCTTAGGAATTCTAGGAAACAAGGAAAG GCATCAACTGTGAAATCTGTGTTAGAATTGATTCCTGAATTAAATGAAAAGGAAGAAGCATACAATTCCCTCATGAAAAGCTATGTCTCA GAGAAAGATGTCACATCTGCTAAAGCACTGTATGAACATTTGACTGCAAAGAATACAAAATTGGATGATCTGTTTCTAAAGCGTTACGCA TCTTTGCTGAAGTATGCTGGAGAGCCTGTCCCTTTCATTGAACCCCCTGAAAGCTTTGAATTTTATGCACAGCAGCTAAGAAAATTGAGG GAAAACTCTTCTTGAAATAACCAGGCGATACTTTGTTTTGTATATATTTGTGATTCTGTGTCTACATGTTATTTTGAAGTATATCTGAGG GAAAAATAAATGAAAATTTTCTTTATGTACTTATGTATGTGTGATGCATGTTCAAAGTCTTATTGACCATAACTCTGTGCACTTGGTTAT TGGACATTTTTGGAGTTTTTTTCTCTGGGAAAAATCGATAGTGTTTTCTTCAATGCTGCTGCTGTGTGAAGCCATACTTTTTCAGGATTC TTCCCCTAATTGGCTCTTTGGTTTCCCTGCTCTGTTTCATTTATTTCATTAAAATGTTATTCCTTTATTTAAGATTCACTTATTAGTCTG CTGTTTCTCTGAAAAATTTTAGAGCTAGGTATAGTGACCGTGAACTTTCTAACGCATAATATTCTGTGATACAGCCATTCCGTACATGTG TGAAGTCCTGCATAACTTTCGAACTTTGTTAAATGTTGGCACTAGGAGTCATCAGATCTAGGCTTCATCATTTTCCAGTGAGAAGCAGAG ACCCAAAGGGCCTGTTACTTGTGCTTGGTCAGGGGACTGTCTGTCATGCCTGGAGGCTCTTCGGCACACTTCCCCATCTTTCCCTTCTGC CACTGTGGCTTCAAGCACCTCTGTTCATAGAGCGTCTCTGAAATTGAGTCTCGGTCATGACTTATCCCGAAGTAGAGCAATGTGTTTCCT CTCATTGTAGTTTCAGGACTTTGTCAGTACAAGCTCTGCCCTAGGCTTGTTACTTTATACTCATATCCTGAAAAGATGTGATTTCATCTA TGAAGGGGTAAAATATTGGTTTGTATTTAATTGTTTGAAATAAAAGTGATCCCTATATTGAATCTCATGCCTGTTAATATCTACACTGTA AGTAGTGACTTCAAAAAAATTCTAAGATAGGTAGTCAGGAGAGTTTGCCATTATAAAAGGTGTCTTAATAATATGGAATATTGACCTAAC TGGAGATGAGGTAATTAATTACCGAAATGTTGAAAATGTTTTGAGAACTCTCCCCATTTTGGGGTATTCCTTGTTCATTTGAATTTGGTG ACTCCCTACTGTTCCAGTTTCAGTGCCAACTTGGGTCACACTGTTCACATCAGGGGAGACCTTGCCTTGGGGACGTAGGCGGGCCTCTTG CAACTTGTGCTGTTGACCTTCTGTCTTGTGGAACTCTCTCTCCTGCATCTGCTACCTGCCCGCAGATGGTGTGAGGGAGGGTTGATGGCG GGAAGCCAGGAAGTAGATGTCATCATGGTATTGGCCAGGCTTTTACTTCAACTCTTTTTGTGGCGTTAGATTTAAGGAAGCAGGGGGCAT GGCCAACGTTGAGTCTTGGCCCAGTGGACATAGTGCGGCTTTCCCTTGAGCACTGCCCAGATGCAGGACCTGCACATGTTACAGGTTTGC CAAAAGCATCTTTTTTTTTTTTTTTTTTTTTGAGATAGTCTTGCTCTGTTGCTTAAGCCAGAGTGCAGTGGCGCAATCTCAGCTCACTGC AACCTCCGCCTCCTGGGTTCAAGTGATTCTTGTGCCTCAGCCTCCCACGTAGCTGAGATTACAGGCTTGCACCACCATGTTCAGCTAATT TTTGTATGGTAAAGACGGAGTTTCACCATGTTGGCCAGGTTGGTCTCGAACTCCTGGCCCCAAGTGATCCTCCCCCTGCGCTCGCTTCAG CCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCTGGCCAAGAGCCTCACTCCTGTCTTTAGTGATTGCACTGAAGCAGGCCT CATTTTTTTGCAGTCATGCTAACCACAAGTTAGTCAACATTCACTAATTGACATTCATTAGAATAGGTCTCCAAGGTGAGGCATAACGTT GGGGTGTAATCTGGATTTCGCAGTCATCTTTTTGGGGAAACTGAAAGTACCATCTCATTTGCATGAAGTGACTCCACACTGGCCCTGTAT ATGGACTCTGGTAAAATGTGAGTGTGGTACAGAGGAAATAGGTAAGACCCCCTTATCTAGCCCTCTCGGCAGCAGCGGGGGGGTGTTACA >39599_39599_3_IL7R-LRPPRC_IL7R_chr5_35867565_ENST00000506850_LRPPRC_chr2_44171033_ENST00000260665_length(amino acids)=755AA_BP=126 MTILGTTFGMVFSLLQVVSGESGYAQNGDLEDAELDDYSFSCYSQLEVNGSQHSLTCAFEDPDVNITNLEFEICGALVEVKCLNFRKLQE IYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIDAINILKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAE PSTNISFPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKK IIETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEI LREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEV KAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVF INNIALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDD ARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRY -------------------------------------------------------------- >39599_39599_4_IL7R-LRPPRC_IL7R_chr5_35867565_ENST00000511982_LRPPRC_chr2_44171033_ENST00000260665_length(transcript)=4435nt_BP=454nt TTCCTCCCTCCCTCCCTTCCTCTTACTCTCATTCATTTCATACACACTGGCTCACACATCTACTCTCTCTCTCTATCTCTCTCAGAATGA CAATTCTAGGTACAACTTTTGGCATGGTTTTTTCTTTACTTCAAGTCGTTTCTGGAGAAAGTGGCTATGCTCAAAATGGAGACTTGGAAG ATGCAGAACTGGATGACTACTCATTCTCATGCTATAGCCAGTTGGAAGTGAATGGATCGCAGCACTCACTGACCTGTGCTTTTGAGGACC CAGATGTCAACATCACCAATCTGGAATTTGAAATATGGTAAGAAGTTGTATATAAAAGTATGGTTGTCACTTTTGGGCTACCTGAAAACA CTGTGTCTGGACATTCTGTAGGTTAAAAGTAGACAAATAGTGGAAACAACTGGCAATAGATAATAGCTAATTCCCTACTGTAAATTTTTA TAATATGCTATTAACATTCTGAAGGAGATGAAAGAGAAGGATGTTCTTATCAAAGATACAACAGCCTTGTCCTTTTTCCACATGCTAAAT GGCGCAGCTTTAAGAGGTGAAATTGAAACAGTAAAACAGTTGCATGAAGCCATCGTGACTCTAGGGTTAGCAGAACCATCCACCAACATA AGTTTCCCATTGGTCACTGTACACTTGGAAAAGGGCGACCTATCTACTGCTCTTGAGGTCGCCATTGACTGCTATGAAAAGTATAAAGTA TTACCAAGGATTCATGATGTCTTGTGTAAACTGGTAGAGAAAGGCGAGACTGATCTAATTCAGAAAGCAATGGACTTTGTGAGCCAAGAA CAAGGTGAAATGGTGATGCTCTATGATCTCTTCTTTGCCTTCCTACAAACAGGAAATTACAAAGAGGCCAAGAAGATCATTGAGACTCCA GGGATTAGAGCTCGATCTGCAAGGCTTCAGTGGTTTTGTGACAGATGTGTTGCAAATAATCAGGTTGAAACTCTGGAAAAATTAGTGGAG CTGACACAGAAGCTATTTGAATGTGATAGAGACCAGATGTACTACAATCTGCTAAAACTGTATAAAATAAACGGTGACTGGCAAAGAGCT GATGCAGTCTGGAATAAAATCCAAGAAGAAAATGTTATTCCTCGTGAAAAGACATTAAGATTATTAGCAGAAATCCTTAGAGAGGGTAAC CAGGAAGTTCCGTTTGACGTACCTGAGTTGTGGTATGAAGATGAAAAACATTCCCTGAATTCTTCGTCAGCCTCAACCACAGAACCTGAT TTCCAGAAAGATATATTGATTGCCTGCCGATTGAACCAAAAAAAAGGGGCATATGATATTTTCCTGAATGCAAAAGAGCAAAACATTGTG TTTAATGCTGAAACCTACAGCAATCTCATTAAATTACTGATGTCAGAAGATTATTTTACACAAGCAATGGAAGTGAAAGCATTCGCGGAG ACCCACATCAAGGGCTTCACACTGAACGATGCTGCCAACAGCCGCCTCATCATAACGCAAGTTAGGCGGGATTATTTGAAAGAGGCTGTG ACAACACTGAAAACAGTATTGGATCAGCAGCAGACCCCTTCTAGGTTAGCAGTGACCCGTGTCATCCAGGCATTGGCCATGAAGGGTGAT GTTGAAAACATAGAAGTAGTTCAGAAGATGTTAAATGGACTCGAAGACTCCATTGGACTTTCAAAAATGGTTTTCATCAATAACATTGCT TTGGCTCAAATAAAGAATAATAACATAGATGCCGCAATAGAAAACATTGAAAATATGCTTACTTCAGAGAATAAAGTCATTGAACCCCAA TACTTCGGCTTGGCATACTTATTCAGAAAAGTAATAGAGGAGCAGTTGGAACCAGCAGTTGAAAAGATAAGCATCATGGCGGAGAGATTG GCCAATCAGTTTGCAATTTATAAACCTGTCACTGATTTTTTCCTTCAACTTGTGGATGCAGGCAAGGTGGATGATGCCAGAGCTCTCCTA CAGAGATGTGGTGCAATTGCTGAACAAACCCCGATTTTGTTGTTGTTCCTCCTTAGGAATTCTAGGAAACAAGGAAAGGCATCAACTGTG AAATCTGTGTTAGAATTGATTCCTGAATTAAATGAAAAGGAAGAAGCATACAATTCCCTCATGAAAAGCTATGTCTCAGAGAAAGATGTC ACATCTGCTAAAGCACTGTATGAACATTTGACTGCAAAGAATACAAAATTGGATGATCTGTTTCTAAAGCGTTACGCATCTTTGCTGAAG TATGCTGGAGAGCCTGTCCCTTTCATTGAACCCCCTGAAAGCTTTGAATTTTATGCACAGCAGCTAAGAAAATTGAGGGAAAACTCTTCT TGAAATAACCAGGCGATACTTTGTTTTGTATATATTTGTGATTCTGTGTCTACATGTTATTTTGAAGTATATCTGAGGGAAAAATAAATG AAAATTTTCTTTATGTACTTATGTATGTGTGATGCATGTTCAAAGTCTTATTGACCATAACTCTGTGCACTTGGTTATTGGACATTTTTG GAGTTTTTTTCTCTGGGAAAAATCGATAGTGTTTTCTTCAATGCTGCTGCTGTGTGAAGCCATACTTTTTCAGGATTCTTCCCCTAATTG GCTCTTTGGTTTCCCTGCTCTGTTTCATTTATTTCATTAAAATGTTATTCCTTTATTTAAGATTCACTTATTAGTCTGCTGTTTCTCTGA AAAATTTTAGAGCTAGGTATAGTGACCGTGAACTTTCTAACGCATAATATTCTGTGATACAGCCATTCCGTACATGTGTGAAGTCCTGCA TAACTTTCGAACTTTGTTAAATGTTGGCACTAGGAGTCATCAGATCTAGGCTTCATCATTTTCCAGTGAGAAGCAGAGACCCAAAGGGCC TGTTACTTGTGCTTGGTCAGGGGACTGTCTGTCATGCCTGGAGGCTCTTCGGCACACTTCCCCATCTTTCCCTTCTGCCACTGTGGCTTC AAGCACCTCTGTTCATAGAGCGTCTCTGAAATTGAGTCTCGGTCATGACTTATCCCGAAGTAGAGCAATGTGTTTCCTCTCATTGTAGTT TCAGGACTTTGTCAGTACAAGCTCTGCCCTAGGCTTGTTACTTTATACTCATATCCTGAAAAGATGTGATTTCATCTATGAAGGGGTAAA ATATTGGTTTGTATTTAATTGTTTGAAATAAAAGTGATCCCTATATTGAATCTCATGCCTGTTAATATCTACACTGTAAGTAGTGACTTC AAAAAAATTCTAAGATAGGTAGTCAGGAGAGTTTGCCATTATAAAAGGTGTCTTAATAATATGGAATATTGACCTAACTGGAGATGAGGT AATTAATTACCGAAATGTTGAAAATGTTTTGAGAACTCTCCCCATTTTGGGGTATTCCTTGTTCATTTGAATTTGGTGACTCCCTACTGT TCCAGTTTCAGTGCCAACTTGGGTCACACTGTTCACATCAGGGGAGACCTTGCCTTGGGGACGTAGGCGGGCCTCTTGCAACTTGTGCTG TTGACCTTCTGTCTTGTGGAACTCTCTCTCCTGCATCTGCTACCTGCCCGCAGATGGTGTGAGGGAGGGTTGATGGCGGGAAGCCAGGAA GTAGATGTCATCATGGTATTGGCCAGGCTTTTACTTCAACTCTTTTTGTGGCGTTAGATTTAAGGAAGCAGGGGGCATGGCCAACGTTGA GTCTTGGCCCAGTGGACATAGTGCGGCTTTCCCTTGAGCACTGCCCAGATGCAGGACCTGCACATGTTACAGGTTTGCCAAAAGCATCTT TTTTTTTTTTTTTTTTTTTGAGATAGTCTTGCTCTGTTGCTTAAGCCAGAGTGCAGTGGCGCAATCTCAGCTCACTGCAACCTCCGCCTC CTGGGTTCAAGTGATTCTTGTGCCTCAGCCTCCCACGTAGCTGAGATTACAGGCTTGCACCACCATGTTCAGCTAATTTTTGTATGGTAA AGACGGAGTTTCACCATGTTGGCCAGGTTGGTCTCGAACTCCTGGCCCCAAGTGATCCTCCCCCTGCGCTCGCTTCAGCCTCCCAAAGTG CTGGGATTACAGGTGTGAGCCACCACGCCTGGCCAAGAGCCTCACTCCTGTCTTTAGTGATTGCACTGAAGCAGGCCTCATTTTTTTGCA GTCATGCTAACCACAAGTTAGTCAACATTCACTAATTGACATTCATTAGAATAGGTCTCCAAGGTGAGGCATAACGTTGGGGTGTAATCT GGATTTCGCAGTCATCTTTTTGGGGAAACTGAAAGTACCATCTCATTTGCATGAAGTGACTCCACACTGGCCCTGTATATGGACTCTGGT AAAATGTGAGTGTGGTACAGAGGAAATAGGTAAGACCCCCTTATCTAGCCCTCTCGGCAGCAGCGGGGGGGTGTTACAAAGGACTAGCTG >39599_39599_4_IL7R-LRPPRC_IL7R_chr5_35867565_ENST00000511982_LRPPRC_chr2_44171033_ENST00000260665_length(amino acids)=624AA_BP= MKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAEPSTNISFPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHD VLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKKIIETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLF ECDRDQMYYNLLKLYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEILREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQKDIL IACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEVKAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTV LDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFINNIALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGLAY LFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDDARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLEL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for IL7R-LRPPRC |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for IL7R-LRPPRC |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for IL7R-LRPPRC |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | IL7R | C0026769 | Multiple Sclerosis | 4 | CTD_human |
Hgene | IL7R | C0751324 | Multiple Sclerosis, Acute Fulminating | 4 | CTD_human |
Hgene | IL7R | C1837028 | Severe Combined Immunodeficiency, Autosomal Recessive, T Cell Negative, B Cell Positive, NK Cell Positive | 2 | CTD_human;ORPHANET;UNIPROT |
Hgene | IL7R | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | IL7R | C0008312 | Primary biliary cirrhosis | 1 | CTD_human |
Hgene | IL7R | C0009324 | Ulcerative Colitis | 1 | CTD_human |
Hgene | IL7R | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | IL7R | C0023892 | Biliary cirrhosis | 1 | CTD_human |
Hgene | IL7R | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | IL7R | C0238065 | Secondary Biliary Cholangitis | 1 | CTD_human |
Hgene | IL7R | C0269102 | Endometrioma | 1 | CTD_human |
Hgene | IL7R | C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 1 | CGI;CTD_human |
Hgene | IL7R | C4551595 | Biliary Cirrhosis, Primary, 1 | 1 | CTD_human |
Tgene | C0023264 | Leigh Disease | 8 | CLINGEN | |
Tgene | C1838951 | LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY | 8 | CLINGEN | |
Tgene | C1850597 | Leigh Syndrome Due To Mitochondrial Complex II Deficiency | 8 | CLINGEN | |
Tgene | C1850598 | Leigh Syndrome due to Mitochondrial Complex III Deficiency | 8 | CLINGEN | |
Tgene | C1850599 | Leigh Syndrome due to Mitochondrial Complex IV Deficiency | 8 | CLINGEN | |
Tgene | C1850600 | Leigh Syndrome due to Mitochondrial Complex V Deficiency | 8 | CLINGEN | |
Tgene | C2931891 | Necrotizing encephalopathy, infantile subacute, of Leigh | 8 | CLINGEN | |
Tgene | C1857355 | Leigh syndrome , French Canadian type | 4 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0751651 | Mitochondrial Diseases | 1 | GENOMICS_ENGLAND |