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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:JUN-MPV17 (FusionGDB2 ID:HG3725TG4358)

Fusion Gene Summary for JUN-MPV17

check button Fusion gene summary
Fusion gene informationFusion gene name: JUN-MPV17
Fusion gene ID: hg3725tg4358
HgeneTgene
Gene symbol

JUN

MPV17

Gene ID

3725

4358

Gene nameJun proto-oncogene, AP-1 transcription factor subunitmitochondrial inner membrane protein MPV17
SynonymsAP-1|AP1|c-Jun|cJUN|p39CMT2EE|MTDPS6|SYM1
Cytomap('JUN')('MPV17')

1p32.1

2p23.3

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor AP-1Jun activation domain binding proteinactivator protein 1enhancer-binding protein AP1jun oncogeneproto-oncogene c-Junproto-oncogene cJunv-jun avian sarcoma virus 17 oncogene homologv-jun sarcoma virus 17 oncogene homologprotein Mpv17MPV17, mitochondrial inner membrane proteinMpV17 mitochondrial inner membrane proteinMpv17, human homolog of glomerulosclerosis and nephrotic syndrome
Modification date2020031320200313
UniProtAcc

P05412

P39210

Ensembl transtripts involved in fusion geneENST00000371222, 
Fusion gene scores* DoF score5 X 5 X 1=254 X 4 X 3=48
# samples 54
** MAII scorelog2(5/25*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: JUN [Title/Abstract] AND MPV17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointJUN(59248665)-MPV17(27532533), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneJUN

GO:0007179

transforming growth factor beta receptor signaling pathway

9732876

HgeneJUN

GO:0007265

Ras protein signal transduction

24623306

HgeneJUN

GO:0043392

negative regulation of DNA binding

14645924

HgeneJUN

GO:0043922

negative regulation by host of viral transcription

2833704

HgeneJUN

GO:0043923

positive regulation by host of viral transcription

2833704

HgeneJUN

GO:0045892

negative regulation of transcription, DNA-templated

2833704

HgeneJUN

GO:0045893

positive regulation of transcription, DNA-templated

2833704|9732876|22083952

HgeneJUN

GO:0045944

positive regulation of transcription by RNA polymerase II

2833704|10508860|12490281|19861239

HgeneJUN

GO:0060395

SMAD protein signal transduction

9732876

HgeneJUN

GO:2000144

positive regulation of DNA-templated transcription, initiation

23027619



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACR981234JUNchr1

59248665

-MPV17chr2

27532533

-


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Fusion Gene ORF analysis for JUN-MPV17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000371222ENST00000233545JUNchr1

59248665

-MPV17chr2

27532533

-
intron-3UTRENST00000371222ENST00000357186JUNchr1

59248665

-MPV17chr2

27532533

-
intron-3UTRENST00000371222ENST00000380044JUNchr1

59248665

-MPV17chr2

27532533

-
intron-3UTRENST00000371222ENST00000402310JUNchr1

59248665

-MPV17chr2

27532533

-
intron-3UTRENST00000371222ENST00000402722JUNchr1

59248665

-MPV17chr2

27532533

-
intron-3UTRENST00000371222ENST00000405983JUNchr1

59248665

-MPV17chr2

27532533

-
intron-intronENST00000371222ENST00000399052JUNchr1

59248665

-MPV17chr2

27532533

-
intron-intronENST00000371222ENST00000403262JUNchr1

59248665

-MPV17chr2

27532533

-
intron-intronENST00000371222ENST00000405076JUNchr1

59248665

-MPV17chr2

27532533

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for JUN-MPV17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for JUN-MPV17


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:59248665/:27532533)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
JUN

P05412

MPV17

P39210

FUNCTION: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:10995748, PubMed:22083952). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). {ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24623306}.FUNCTION: Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis (PubMed:25861990). Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance (PubMed:26760297). May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (By similarity). {ECO:0000250|UniProtKB:P19258, ECO:0000269|PubMed:25861990, ECO:0000269|PubMed:26760297}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for JUN-MPV17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for JUN-MPV17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for JUN-MPV17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneJUNP05412DB00210AdapaleneAntagonistSmall moleculeApproved
HgeneJUNP05412DB00570VinblastineOther/unknownSmall moleculeApproved
HgeneJUNP05412DB01029IrbesartanOther/unknownSmall moleculeApproved|Investigational
HgeneJUNP05412DB01169Arsenic trioxideInducerSmall moleculeApproved|Investigational

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Related Diseases for JUN-MPV17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneJUNC0007102Malignant tumor of colon2CTD_human
HgeneJUNC0007621Neoplastic Cell Transformation2CTD_human
HgeneJUNC0009375Colonic Neoplasms2CTD_human
HgeneJUNC0023903Liver neoplasms2CTD_human
HgeneJUNC0036341Schizophrenia2PSYGENET
HgeneJUNC0345904Malignant neoplasm of liver2CTD_human
HgeneJUNC0005398Cholestasis, Extrahepatic1CTD_human
HgeneJUNC0006142Malignant neoplasm of breast1CTD_human
HgeneJUNC0007786Brain Ischemia1CTD_human
HgeneJUNC0018923Hemangiosarcoma1CTD_human
HgeneJUNC0020538Hypertensive disease1CTD_human
HgeneJUNC0021846Intestinal Polyps1CTD_human
HgeneJUNC0024121Lung Neoplasms1CTD_human
HgeneJUNC0024623Malignant neoplasm of stomach1CTD_human
HgeneJUNC0029463Osteosarcoma1CTD_human
HgeneJUNC0035126Reperfusion Injury1CTD_human
HgeneJUNC0037116Silicosis1CTD_human
HgeneJUNC0038220Status Epilepticus1CTD_human
HgeneJUNC0038356Stomach Neoplasms1CTD_human
HgeneJUNC0086626Minamata Disease1CTD_human
HgeneJUNC0087031Juvenile-Onset Still Disease1CTD_human
HgeneJUNC0242379Malignant neoplasm of lung1CTD_human
HgeneJUNC0270823Petit mal status1CTD_human
HgeneJUNC0274859Inorganic Mercury Poisoning1CTD_human
HgeneJUNC0274860Mercury Poisoning, Organic1CTD_human
HgeneJUNC0311335Grand Mal Status Epilepticus1CTD_human
HgeneJUNC0393734Complex Partial Status Epilepticus1CTD_human
HgeneJUNC0546127Mercury Poisoning, Nervous System1CTD_human
HgeneJUNC0678222Breast Carcinoma1CTD_human
HgeneJUNC0751522Status Epilepticus, Subclinical1CTD_human
HgeneJUNC0751523Non-Convulsive Status Epilepticus1CTD_human
HgeneJUNC0751524Simple Partial Status Epilepticus1CTD_human
HgeneJUNC0751855Mercury Encephalopathy1CTD_human
HgeneJUNC0751856Mad Hatter Disease1CTD_human
HgeneJUNC0751857Mercurial Neuroanesthenia1CTD_human
HgeneJUNC0751858Mercury Psychosis1CTD_human
HgeneJUNC0917798Cerebral Ischemia1CTD_human
HgeneJUNC1257931Mammary Neoplasms, Human1CTD_human
HgeneJUNC1458155Mammary Neoplasms1CTD_human
HgeneJUNC1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneJUNC2239176Liver carcinoma1CTD_human
HgeneJUNC3495559Juvenile arthritis1CTD_human
HgeneJUNC3714758Juvenile psoriatic arthritis1CTD_human
HgeneJUNC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneJUNC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
HgeneJUNC4704874Mammary Carcinoma, Human1CTD_human
HgeneJUNC4721453Peripheral Nervous System Diseases1CTD_human
TgeneC1850406NAVAJO NEUROHEPATOPATHY18CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0008370Cholestasis1GENOMICS_ENGLAND
TgeneC0009197Cochlear Diseases1CTD_human
TgeneC0017668Focal glomerulosclerosis1CTD_human
TgeneC0022283Incontinentia Pigmenti Achromians1CTD_human
TgeneC0033687Proteinuria1CTD_human
TgeneC0036305Schamberg Disease1CTD_human
TgeneC0085605Liver Failure1GENOMICS_ENGLAND
TgeneC0086432Hyalinosis, Segmental Glomerular1CTD_human
TgeneC0344307Absence of pain sensation1GENOMICS_ENGLAND
TgeneC0549567Pigmentation Disorders1CTD_human
TgeneC0751651Mitochondrial Diseases1CTD_human
TgeneC0949855Electron Transport Chain Deficiencies, Mitochondrial1CTD_human
TgeneC0949856Oxidative Phosphorylation Deficiencies1CTD_human
TgeneC0949857Mitochondrial Respiratory Chain Deficiencies1CTD_human