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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
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Fusion gene:KCNB1-MICAL2 (FusionGDB2 ID:HG3745TG9645) |
Fusion Gene Summary for KCNB1-MICAL2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: KCNB1-MICAL2 | Fusion gene ID: hg3745tg9645 | Hgene | Tgene | Gene symbol | KCNB1 | MICAL2 | Gene ID | 3745 | 9645 |
Gene name | potassium voltage-gated channel subfamily B member 1 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | |
Synonyms | DRK1|Kv2.1 | MICAL-2|MICAL2PV1|MICAL2PV2 | |
Cytomap | ('KCNB1')('MICAL2') 20q13.13 | 11p15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | potassium voltage-gated channel subfamily B member 1delayed rectifier potassium channel 1potassium voltage-gated channel, Shab-related subfamily, member 1voltage-gated potassium channel subunit Kv2.1 | [F-actin]-monooxygenase MICAL2[F-actin]-methionine sulfoxide oxidase MICAL2flavoprotein oxidoreductase MICAL2microtubule associated monoxygenase, calponin and LIM domain containing 2molecule interacting with CasL protein 2protein-methionine sulfoxide | |
Modification date | 20200329 | 20200320 | |
UniProtAcc | Q14721 | . | |
Ensembl transtripts involved in fusion gene | ENST00000371741, | ||
Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 9 X 10 X 6=540 |
# samples | 6 | 10 | |
** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/540*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: KCNB1 [Title/Abstract] AND MICAL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | KCNB1(48098451)-MICAL2(12225797), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | KCNB1-MICAL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KCNB1-MICAL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KCNB1-MICAL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KCNB1-MICAL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KCNB1 | GO:0001508 | action potential | 19223394 |
Hgene | KCNB1 | GO:0071805 | potassium ion transmembrane transport | 19074135|19223394 |
Hgene | KCNB1 | GO:0090314 | positive regulation of protein targeting to membrane | 19074135 |
Tgene | MICAL2 | GO:0007010 | cytoskeleton organization | 24440334 |
Tgene | MICAL2 | GO:0030042 | actin filament depolymerization | 24440334 |
Tgene | MICAL2 | GO:0055114 | oxidation-reduction process | 24440334 |
Fusion gene breakpoints across KCNB1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across MICAL2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | Non-Cancer | TCGA-HU-A4GP-11A | KCNB1 | chr20 | 48098451 | - | MICAL2 | chr11 | 12225797 | + |
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Fusion Gene ORF analysis for KCNB1-MICAL2 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000371741 | ENST00000527195 | KCNB1 | chr20 | 48098451 | - | MICAL2 | chr11 | 12225797 | + |
In-frame | ENST00000371741 | ENST00000256194 | KCNB1 | chr20 | 48098451 | - | MICAL2 | chr11 | 12225797 | + |
In-frame | ENST00000371741 | ENST00000342902 | KCNB1 | chr20 | 48098451 | - | MICAL2 | chr11 | 12225797 | + |
In-frame | ENST00000371741 | ENST00000379612 | KCNB1 | chr20 | 48098451 | - | MICAL2 | chr11 | 12225797 | + |
In-frame | ENST00000371741 | ENST00000527546 | KCNB1 | chr20 | 48098451 | - | MICAL2 | chr11 | 12225797 | + |
In-frame | ENST00000371741 | ENST00000537344 | KCNB1 | chr20 | 48098451 | - | MICAL2 | chr11 | 12225797 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000371741 | KCNB1 | chr20 | 48098451 | - | ENST00000537344 | MICAL2 | chr11 | 12225797 | + | 3674 | 734 | 167 | 3274 | 1035 |
ENST00000371741 | KCNB1 | chr20 | 48098451 | - | ENST00000256194 | MICAL2 | chr11 | 12225797 | + | 4088 | 734 | 167 | 3844 | 1225 |
ENST00000371741 | KCNB1 | chr20 | 48098451 | - | ENST00000527546 | MICAL2 | chr11 | 12225797 | + | 3674 | 734 | 167 | 3274 | 1035 |
ENST00000371741 | KCNB1 | chr20 | 48098451 | - | ENST00000342902 | MICAL2 | chr11 | 12225797 | + | 3828 | 734 | 167 | 3781 | 1204 |
ENST00000371741 | KCNB1 | chr20 | 48098451 | - | ENST00000379612 | MICAL2 | chr11 | 12225797 | + | 3401 | 734 | 167 | 3400 | 1078 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000371741 | ENST00000537344 | KCNB1 | chr20 | 48098451 | - | MICAL2 | chr11 | 12225797 | + | 0.004968352 | 0.9950316 |
ENST00000371741 | ENST00000256194 | KCNB1 | chr20 | 48098451 | - | MICAL2 | chr11 | 12225797 | + | 0.00227556 | 0.9977245 |
ENST00000371741 | ENST00000527546 | KCNB1 | chr20 | 48098451 | - | MICAL2 | chr11 | 12225797 | + | 0.004968352 | 0.9950316 |
ENST00000371741 | ENST00000342902 | KCNB1 | chr20 | 48098451 | - | MICAL2 | chr11 | 12225797 | + | 0.004552516 | 0.99544746 |
ENST00000371741 | ENST00000379612 | KCNB1 | chr20 | 48098451 | - | MICAL2 | chr11 | 12225797 | + | 0.005317173 | 0.99468285 |
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Fusion Genomic Features for KCNB1-MICAL2 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
KCNB1 | chr20 | 48098450 | - | MICAL2 | chr11 | 12225796 | + | 2.68E-05 | 0.9999732 |
KCNB1 | chr20 | 48098450 | - | MICAL2 | chr11 | 12225796 | + | 2.68E-05 | 0.9999732 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for KCNB1-MICAL2 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:48098451/chr11:12225797) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
KCNB1 | . |
FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:23161216). Plays also a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:8081723, PubMed:1283219, PubMed:10484328, PubMed:12560340, PubMed:19074135, PubMed:19717558, PubMed:24901643). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed:10484328, PubMed:11852086, PubMed:12060745, PubMed:19074135, PubMed:19717558, PubMed:24901643). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the slowly inactivating delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (By similarity). Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed:23161216). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (PubMed:12060745). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (By similarity). {ECO:0000250|UniProtKB:P15387, ECO:0000250|UniProtKB:Q03717, ECO:0000269|PubMed:10484328, ECO:0000269|PubMed:11852086, ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:12560340, ECO:0000269|PubMed:1283219, ECO:0000269|PubMed:19074135, ECO:0000269|PubMed:19717558, ECO:0000269|PubMed:23161216, ECO:0000269|PubMed:24901643, ECO:0000269|PubMed:8081723}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 59_75 | 189 | 859.0 | Region | Self-association |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 1_186 | 189 | 859.0 | Topological domain | Cytoplasmic |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000256194 | 2 | 28 | 1000_1062 | 88 | 1155.0 | Domain | LIM zinc-binding | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000256194 | 2 | 28 | 516_619 | 88 | 1155.0 | Domain | Calponin-homology (CH) | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000342902 | 1 | 26 | 1000_1062 | 88 | 1099.6666666666667 | Domain | LIM zinc-binding | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000342902 | 1 | 26 | 516_619 | 88 | 1099.6666666666667 | Domain | Calponin-homology (CH) | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000379612 | 0 | 19 | 1000_1062 | 88 | 977.0 | Domain | LIM zinc-binding | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000379612 | 0 | 19 | 516_619 | 88 | 977.0 | Domain | Calponin-homology (CH) | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000527546 | 1 | 22 | 1000_1062 | 88 | 935.0 | Domain | LIM zinc-binding | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000527546 | 1 | 22 | 516_619 | 88 | 935.0 | Domain | Calponin-homology (CH) | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000537344 | 2 | 23 | 1000_1062 | 88 | 935.0 | Domain | LIM zinc-binding | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000537344 | 2 | 23 | 516_619 | 88 | 935.0 | Domain | Calponin-homology (CH) | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000256194 | 2 | 28 | 660_681 | 88 | 1155.0 | Motif | Nuclear localization signal | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000342902 | 1 | 26 | 660_681 | 88 | 1099.6666666666667 | Motif | Nuclear localization signal | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000379612 | 0 | 19 | 660_681 | 88 | 977.0 | Motif | Nuclear localization signal | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000527546 | 1 | 22 | 660_681 | 88 | 935.0 | Motif | Nuclear localization signal | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000537344 | 2 | 23 | 660_681 | 88 | 935.0 | Motif | Nuclear localization signal | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000256194 | 2 | 28 | 116_118 | 88 | 1155.0 | Nucleotide binding | FAD | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000256194 | 2 | 28 | 123_125 | 88 | 1155.0 | Nucleotide binding | FAD | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000342902 | 1 | 26 | 116_118 | 88 | 1099.6666666666667 | Nucleotide binding | FAD | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000342902 | 1 | 26 | 123_125 | 88 | 1099.6666666666667 | Nucleotide binding | FAD | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000379612 | 0 | 19 | 116_118 | 88 | 977.0 | Nucleotide binding | FAD | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000379612 | 0 | 19 | 123_125 | 88 | 977.0 | Nucleotide binding | FAD | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000527546 | 1 | 22 | 116_118 | 88 | 935.0 | Nucleotide binding | FAD | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000527546 | 1 | 22 | 123_125 | 88 | 935.0 | Nucleotide binding | FAD | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000537344 | 2 | 23 | 116_118 | 88 | 935.0 | Nucleotide binding | FAD | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000537344 | 2 | 23 | 123_125 | 88 | 935.0 | Nucleotide binding | FAD |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 517_520 | 189 | 859.0 | Compositional bias | Note=Poly-Ser |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 701_706 | 189 | 859.0 | Compositional bias | Note=Poly-Ala |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 365_376 | 189 | 859.0 | Intramembrane | Helical%3B Name%3DPore helix |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 377_384 | 189 | 859.0 | Intramembrane | Ontology_term=ECO:0000250 |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 377_382 | 189 | 859.0 | Motif | Selectivity filter |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 448_481 | 189 | 859.0 | Region | Self-association |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 209_228 | 189 | 859.0 | Topological domain | Extracellular |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 251_259 | 189 | 859.0 | Topological domain | Cytoplasmic |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 281_294 | 189 | 859.0 | Topological domain | Extracellular |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 317_330 | 189 | 859.0 | Topological domain | Cytoplasmic |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 352_364 | 189 | 859.0 | Topological domain | Extracellular |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 385_391 | 189 | 859.0 | Topological domain | Extracellular |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 421_858 | 189 | 859.0 | Topological domain | Cytoplasmic |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 187_208 | 189 | 859.0 | Transmembrane | Helical%3B Name%3DSegment S1 |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 229_250 | 189 | 859.0 | Transmembrane | Helical%3B Name%3DSegment S2 |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 260_280 | 189 | 859.0 | Transmembrane | Helical%3B Name%3DSegment S3 |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 295_316 | 189 | 859.0 | Transmembrane | Helical%3B Voltage-sensor%3B Name%3DSegment S4 |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 331_351 | 189 | 859.0 | Transmembrane | Helical%3B Name%3DSegment S5 |
Hgene | KCNB1 | chr20:48098451 | chr11:12225797 | ENST00000371741 | - | 1 | 2 | 392_420 | 189 | 859.0 | Transmembrane | Helical%3B Name%3DSegment S6 |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000256194 | 2 | 28 | 2_494 | 88 | 1155.0 | Region | Monooxygenase domain | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000342902 | 1 | 26 | 2_494 | 88 | 1099.6666666666667 | Region | Monooxygenase domain | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000379612 | 0 | 19 | 2_494 | 88 | 977.0 | Region | Monooxygenase domain | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000527546 | 1 | 22 | 2_494 | 88 | 935.0 | Region | Monooxygenase domain | |
Tgene | MICAL2 | chr20:48098451 | chr11:12225797 | ENST00000537344 | 2 | 23 | 2_494 | 88 | 935.0 | Region | Monooxygenase domain |
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Fusion Gene Sequence for KCNB1-MICAL2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>41366_41366_1_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000256194_length(transcript)=4088nt_BP=734nt GCCGTCGGGATGGAGGTGAGAAGACGGCCGTGACGCGCGCCCGCGGGGCCCCCTGCACCCCCAGCAGCCCACAGCGCTCCCTGCCCCCCT CCCCCGCAGCAGCGGGCCTTGCCGTCGAGTGACAGCGGCCTGGGGGGGCAGGGGGGGCGGGGGCGGCCGGATCAGCGATGCCGGCGGGCA TGACGAAGCATGGCTCCCGCTCCACCAGCTCGCTGCCGCCCGAGCCCATGGAGATCGTGCGCAGCAAGGCGTGCTCTCGGCGGGTCCGCC TCAACGTCGGGGGGCTGGCGCACGAGGTACTCTGGCGTACCCTGGACCGCCTGCCCCGCACGCGGCTGGGCAAGCTCCGCGACTGCAACA CGCACGACTCGCTGCTCGAGGTGTGCGATGACTACAGCCTCGACGACAACGAGTACTTCTTTGACCGCCACCCGGGCGCCTTCACCTCCA TCCTCAACTTCTACCGCACTGGGCGACTGCACATGATGGAGGAGATGTGCGCGCTCAGCTTCAGCCAAGAGCTCGACTACTGGGGCATCG ACGAGATCTACCTGGAGTCCTGCTGCCAGGCCCGCTACCACCAGAAGAAAGAGCAGATGAACGAGGAGCTCAAGCGTGAGGCCGAGACCC TACGGGAGCGGGAAGGCGAGGAGTTCGATAACACGTGCTGCGCAGAGAAGAGGAAAAAACTCTGGGACCTACTGGAGAAGCCCAATTCCT CTGTGGCTGCCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCG TGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGA AGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGG GAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAAT TTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAA GAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTA GTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGG ACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGC TGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCT TAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGC GGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTG GCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTC TCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACC TCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGG TGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACC AGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCA ACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGA CCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCA CCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATC TCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCA CCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACA AAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGGAACGCCGTGTCTCAG GGATAGGTAAGCCGGTCCTGTGCTCTTCCTCCGGCCCTCCTGTTCACTCTTGCTGCCCCAAGCCGGAGGAGGCCACACCCAGCCCATCAC CTCCTCTGAAAAGGCAGTTCCCCTCTGTGGTCGTGACGGGGCACGTGCTCAGAGAGCTCAAGCAAGTGTCTGCTGGCAGTGAGTGCCTGA GCAGACCTTGGAGAGCCAGAGCCAAGTCTGACCTACAGCTGGGTGGGACAGAAAATTTCGCTACCCTGCCTTCTACCCGCCCGAGGGCGC AGGCTCTTTCCGGGGTGCTGTGGCGGCTGCAGCAAGTGGAGGAAAAGATTCTCCAGAAGAGGGCTCAGAACTTGGCCAACAGGGAATTTC ACACAAAGAACATTAAGGAGAAGGCGGCTCACCTTGCCTCCATGTTTGGACACGGGGATTTCCCGCAGAATAAACTACTCTCTAAAGGCC TGTCTCATACTCATCCTCCATCTCCTCCCTCTCGCCTTCCGTCTCCTGATCCAGCTGCTTCTTCCTCTCCATCAACTGTTGACTCTGCTT CTCCTGCCAGAAAGGAAAAGAAGTCACCTTCAGGGTTCCATTTTCATCCCAGCCATTTGAGAACAGTGCATCCTCAGCTGACGGTAGGGA AAGTGTCCAGCGGAATAGGGGCTGCAGCTGAAGTCCTGGTCAATCTGTACATGAATGATCACAGACCTAAGGCCCAGGCCACCTCTCCAG ACCTGGAATCTATGCGAAAGTCATTTCCCCTTAACCTGGGAGGCAGCGACACGTGTTACTTCTGTAAGAAACGTGTGTACGTGATGGAAC GGCTGAGCGCCGAGGGCCACTTCTTCCACCGGGAGTGTTTCCGCTGCAGCATCTGTGCCACCACCTTGCGCCTGGCCGCCTACACCTTTG ACTGCGATGAAGGCAAATTTTACTGCAAGCCTCACTTCATTCACTGTAAAACCAATAGCAAACAACGGAAGAGACGGGCAGAGTTGAAGC AACAAAGAGAGGAGGAGGCAACATGGCAAGAGCAGGAAGCCCCTCGGAGAGACACTCCCACCGAAAGTTCTTGCGCAGTGGCCGCCATTG GCACCCTGGAAGGCAGCCCCCCAGTTCATTTCAGCCTTCCAGTGCTACACCCACTTCTTGGCTGACACACTTCTGCTCTAAGAGTCTCCC TCCCTTTATAGAATGTCAACCAAAGAGTGCCCTCCTCCCCTCTCAGCCTCCTCTTTAGCTAGCCTCCCCATCTCATCACAACGCATGTCT GTGACCTTTGGTAATCATTTACAGTGCCACACGGAACCCTGTATTTTGCACACAGCAAAACAAACAATGTTTAGCTTTATTTATGGTATT >41366_41366_1_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000256194_length(amino acids)=1225AA_BP=189 MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPG AFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLE KPNSSVAAKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKV ALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAK VEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNY QLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLA ERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQ TEGYQHVNVTDLTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYE LFRGTPLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEG GNQNKVKSMANQLLAKFEESTRNPSLMKQERRVSGIGKPVLCSSSGPPVHSCCPKPEEATPSPSPPLKRQFPSVVVTGHVLRELKQVSAG SECLSRPWRARAKSDLQLGGTENFATLPSTRPRAQALSGVLWRLQQVEEKILQKRAQNLANREFHTKNIKEKAAHLASMFGHGDFPQNKL LSKGLSHTHPPSPPSRLPSPDPAASSSPSTVDSASPARKEKKSPSGFHFHPSHLRTVHPQLTVGKVSSGIGAAAEVLVNLYMNDHRPKAQ ATSPDLESMRKSFPLNLGGSDTCYFCKKRVYVMERLSAEGHFFHRECFRCSICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRR -------------------------------------------------------------- >41366_41366_2_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000342902_length(transcript)=3828nt_BP=734nt GCCGTCGGGATGGAGGTGAGAAGACGGCCGTGACGCGCGCCCGCGGGGCCCCCTGCACCCCCAGCAGCCCACAGCGCTCCCTGCCCCCCT CCCCCGCAGCAGCGGGCCTTGCCGTCGAGTGACAGCGGCCTGGGGGGGCAGGGGGGGCGGGGGCGGCCGGATCAGCGATGCCGGCGGGCA TGACGAAGCATGGCTCCCGCTCCACCAGCTCGCTGCCGCCCGAGCCCATGGAGATCGTGCGCAGCAAGGCGTGCTCTCGGCGGGTCCGCC TCAACGTCGGGGGGCTGGCGCACGAGGTACTCTGGCGTACCCTGGACCGCCTGCCCCGCACGCGGCTGGGCAAGCTCCGCGACTGCAACA CGCACGACTCGCTGCTCGAGGTGTGCGATGACTACAGCCTCGACGACAACGAGTACTTCTTTGACCGCCACCCGGGCGCCTTCACCTCCA TCCTCAACTTCTACCGCACTGGGCGACTGCACATGATGGAGGAGATGTGCGCGCTCAGCTTCAGCCAAGAGCTCGACTACTGGGGCATCG ACGAGATCTACCTGGAGTCCTGCTGCCAGGCCCGCTACCACCAGAAGAAAGAGCAGATGAACGAGGAGCTCAAGCGTGAGGCCGAGACCC TACGGGAGCGGGAAGGCGAGGAGTTCGATAACACGTGCTGCGCAGAGAAGAGGAAAAAACTCTGGGACCTACTGGAGAAGCCCAATTCCT CTGTGGCTGCCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCG TGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGA AGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGG GAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAAT TTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAA GAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTA GTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGG ACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGC TGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCT TAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGC GGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTG GCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTC TCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACC TCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGG TGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACC AGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCA ACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGA CCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCA CCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATC TCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCA CCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACA AAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGGAACGCCGTGTCTCAG GGATAGGTAAGCCGGTCCTGTGCTCTTCCTCCGGCCCTCCTGTTCACTCTTGCTGCCCCAAGCCGGAGGAGGCCACACCCAGCCCATCAC CTCCTCTGAAAAGGCAGTTCCCCTCTGTGGTCGTGACGGGGCACGTGCTCAGAGAGCTCAAGCAAGTGTCTGCTGGCAGTGAGTGCCTGA GCAGACCTTGGAGAGCCAGAGCCAAGTCTGACCTACAGCTGGGTGGGACAGAAAATTTCGCTACCCTGCCTTCTACCCGCCCGAGGGCGC AGGCTCTTTCCGGGGTGCTGTGGCGGCTGCAGCAAGTGGAGGAAAAGATTCTCCAGAAGAGGGCTCAGAACTTGGCCAACAGGGAATTTC ACACAAAGAACATTAAGGAGAAGGCGGCTCACCTTGCCTCCATGTTTGGACACGGGGATTTCCCGCAGAATAAACTACTCTCTAAAGGCC TGTCTCATACTCATCCTCCATCTCCTCCCTCTCGCCTTCCGTCTCCTGATCCAGCTGCTTCTTCCTCTCCATCAACTGTTGACTCTGCTT CTCCTGCCAGAAAGCTGACGGTAGGGAAAGTGTCCAGCGGAATAGGGGCTGCAGCTGAAGTCCTGGTCAATCTGTACATGAATGATCACA GACCTAAGGCCCAGGCCACCTCTCCAGACCTGGAATCTATGCGAAAGTCATTTCCCCTTAACCTGGGAGGCAGCGACACGTGTTACTTCT GTAAGAAACGTGTGTACGTGATGGAACGGCTGAGCGCCGAGGGCCACTTCTTCCACCGGGAGTGTTTCCGCTGCAGCATCTGTGCCACCA CCTTGCGCCTGGCCGCCTACACCTTTGACTGCGATGAAGGCAAATTTTACTGCAAGCCTCACTTCATTCACTGTAAAACCAATAGCAAAC AACGGAAGAGACGGGCAGAGTTGAAGCAACAAAGAGAGGAGGAGGCAACATGGCAAGAGCAGGAAGCCCCTCGGAGAGACACTCCCACCG AAAGTTCTTGCGCAGTGGCCGCCATTGGCACCCTGGAAGGCAGCCCCCCAGTTCATTTCAGCCTTCCAGTGCTACACCCACTTCTTGGCT >41366_41366_2_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000342902_length(amino acids)=1204AA_BP=189 MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPG AFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLE KPNSSVAAKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKV ALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAK VEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNY QLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLA ERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQ TEGYQHVNVTDLTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYE LFRGTPLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEG GNQNKVKSMANQLLAKFEESTRNPSLMKQERRVSGIGKPVLCSSSGPPVHSCCPKPEEATPSPSPPLKRQFPSVVVTGHVLRELKQVSAG SECLSRPWRARAKSDLQLGGTENFATLPSTRPRAQALSGVLWRLQQVEEKILQKRAQNLANREFHTKNIKEKAAHLASMFGHGDFPQNKL LSKGLSHTHPPSPPSRLPSPDPAASSSPSTVDSASPARKLTVGKVSSGIGAAAEVLVNLYMNDHRPKAQATSPDLESMRKSFPLNLGGSD TCYFCKKRVYVMERLSAEGHFFHRECFRCSICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRRAELKQQREEEATWQEQEAPRR -------------------------------------------------------------- >41366_41366_3_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000379612_length(transcript)=3401nt_BP=734nt GCCGTCGGGATGGAGGTGAGAAGACGGCCGTGACGCGCGCCCGCGGGGCCCCCTGCACCCCCAGCAGCCCACAGCGCTCCCTGCCCCCCT CCCCCGCAGCAGCGGGCCTTGCCGTCGAGTGACAGCGGCCTGGGGGGGCAGGGGGGGCGGGGGCGGCCGGATCAGCGATGCCGGCGGGCA TGACGAAGCATGGCTCCCGCTCCACCAGCTCGCTGCCGCCCGAGCCCATGGAGATCGTGCGCAGCAAGGCGTGCTCTCGGCGGGTCCGCC TCAACGTCGGGGGGCTGGCGCACGAGGTACTCTGGCGTACCCTGGACCGCCTGCCCCGCACGCGGCTGGGCAAGCTCCGCGACTGCAACA CGCACGACTCGCTGCTCGAGGTGTGCGATGACTACAGCCTCGACGACAACGAGTACTTCTTTGACCGCCACCCGGGCGCCTTCACCTCCA TCCTCAACTTCTACCGCACTGGGCGACTGCACATGATGGAGGAGATGTGCGCGCTCAGCTTCAGCCAAGAGCTCGACTACTGGGGCATCG ACGAGATCTACCTGGAGTCCTGCTGCCAGGCCCGCTACCACCAGAAGAAAGAGCAGATGAACGAGGAGCTCAAGCGTGAGGCCGAGACCC TACGGGAGCGGGAAGGCGAGGAGTTCGATAACACGTGCTGCGCAGAGAAGAGGAAAAAACTCTGGGACCTACTGGAGAAGCCCAATTCCT CTGTGGCTGCCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCG TGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGA AGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGG GAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAAT TTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAA GAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTA GTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGG ACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGC TGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCT TAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGC GGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTG GCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTC TCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACC TCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGG TGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACC AGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCA ACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGA CCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCA CCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATC TCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCA CCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACA AAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGGAAAAGAAGTCACCTT CAGGGTTCCATTTTCATCCCAGCCATTTGAGAACAGTGCATCCTCAGGAATCTATGCGAAAGTCATTTCCCCTTAACCTGGGAGGCAGCG ACACGTGTTACTTCTGTAAGAAACGTGTGTACGTGATGGAACGGCTGAGCGCCGAGGGCCACTTCTTCCACCGGGAGTGTTTCCGCTGCA GCATCTGTGCCACCACCTTGCGCCTGGCCGCCTACACCTTTGACTGCGATGAAGGCAAATTTTACTGCAAGCCTCACTTCATTCACTGTA AAACCAATAGCAAACAACGGAAGAGACGGGCAGAGTTGAAGCAACAAAGAGAGGAGGAGGCAACATGGCAAGAGCAGGAAGCCCCTCGGA GAGACACTCCCACCGAAAGTTCTTGCGCAGTGGCCGCCATTGGCACCCTGGAAGGCAGCCCCCCAGGTATCTCCACCTCCTTCTTTAGGA AGGTGCTGGGCTGGCCCCTCAGGCTGCCGAGGGACCTGTGTAACTGGATGCAGGGACTCCTGCAAGCTGCTGGCCTCCATATCAGGGACA ATGCTTACAACTACTGCTACATGTACGAGCTCCTGAGCCTGGGGCTGCCACTCCTCTGGGCGTTCTCTGAGGTCCTGGCAGCCATGTACA >41366_41366_3_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000379612_length(amino acids)=1078AA_BP=189 MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPG AFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLE KPNSSVAAKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKV ALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAK VEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNY QLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLA ERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQ TEGYQHVNVTDLTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYE LFRGTPLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEG GNQNKVKSMANQLLAKFEESTRNPSLMKQEKKSPSGFHFHPSHLRTVHPQESMRKSFPLNLGGSDTCYFCKKRVYVMERLSAEGHFFHRE CFRCSICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRRAELKQQREEEATWQEQEAPRRDTPTESSCAVAAIGTLEGSPPGIST -------------------------------------------------------------- >41366_41366_4_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000527546_length(transcript)=3674nt_BP=734nt GCCGTCGGGATGGAGGTGAGAAGACGGCCGTGACGCGCGCCCGCGGGGCCCCCTGCACCCCCAGCAGCCCACAGCGCTCCCTGCCCCCCT CCCCCGCAGCAGCGGGCCTTGCCGTCGAGTGACAGCGGCCTGGGGGGGCAGGGGGGGCGGGGGCGGCCGGATCAGCGATGCCGGCGGGCA TGACGAAGCATGGCTCCCGCTCCACCAGCTCGCTGCCGCCCGAGCCCATGGAGATCGTGCGCAGCAAGGCGTGCTCTCGGCGGGTCCGCC TCAACGTCGGGGGGCTGGCGCACGAGGTACTCTGGCGTACCCTGGACCGCCTGCCCCGCACGCGGCTGGGCAAGCTCCGCGACTGCAACA CGCACGACTCGCTGCTCGAGGTGTGCGATGACTACAGCCTCGACGACAACGAGTACTTCTTTGACCGCCACCCGGGCGCCTTCACCTCCA TCCTCAACTTCTACCGCACTGGGCGACTGCACATGATGGAGGAGATGTGCGCGCTCAGCTTCAGCCAAGAGCTCGACTACTGGGGCATCG ACGAGATCTACCTGGAGTCCTGCTGCCAGGCCCGCTACCACCAGAAGAAAGAGCAGATGAACGAGGAGCTCAAGCGTGAGGCCGAGACCC TACGGGAGCGGGAAGGCGAGGAGTTCGATAACACGTGCTGCGCAGAGAAGAGGAAAAAACTCTGGGACCTACTGGAGAAGCCCAATTCCT CTGTGGCTGCCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCG TGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGA AGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGG GAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAAT TTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAA GAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTA GTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGG ACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGC TGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCT TAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGC GGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTG GCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTC TCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACC TCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGG TGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACC AGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCA ACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGA CCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCA CCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATC TCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCA CCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACA AAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGGAAAAGAAGTCACCTT CAGGGTTCCATTTTCATCCCAGCCATTTGAGAACAGTGCATCCTCAGCTGACGGTAGGGAAAGTGTCCAGCGGAATAGGGGCTGCAGCTG AAGTCCTGGTCAATCTGTACATGAATGATCACAGACCTAAGGCCCAGGCCACCTCTCCAGACCTGGAATCTATGCGAAAGTCATTTCCCC TTAACCTGGGAGGCAGCGACACGTGTTACTTCTGTAAGAAACGTGTGTACGTGATGGAACGGCTGAGCGCCGAGGGCCACTTCTTCCACC GGGAGTGTTTCCGCTGCAGCATCTGTGCCACCACCTTGCGCCTGGCCGCCTACACCTTTGACTGCGATGAAGGCAAATTTTACTGCAAGC CTCACTTCATTCACTGTAAAACCAATAGCAAACAACGGAAGAGACGGGCAGAGTTGAAGCAACAAAGAGAGGAGGAGGCAACATGGCAAG AGCAGGAAGCCCCTCGGAGAGACACTCCCACCGAAAGTTCTTGCGCAGTGGCCGCCATTGGCACCCTGGAAGGCAGCCCCCCAGTTCATT TCAGCCTTCCAGTGCTACACCCACTTCTTGGCTGACACACTTCTGCTCTAAGGTGACTGGTTTTCTTGCCAATTTTCAAAGAGTGGTACT AACCCCCAACCCGCTTTCCGCACCCCGTCCTCTCCGCCAGCAGTACTGGTTGCACTAACTGTGAGTGTCTTGCATACTGATGGACTCATT TGGTGGCATGGTTGGCTAACAGCATGGCGGGGGGTGTTCAGCTTGAGACCCATGCCTGTGTTCATTTCCCATGGAGCTGGCAGCCTGGTC TACCCCAAGTGCATGCCCCGCCTCTCCTCTCTCCCTTGGGTCTGCCTGCGTGCATGCTTCTCCAGTTGCGTCTGCGAAGCTACCTACTTT >41366_41366_4_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000527546_length(amino acids)=1035AA_BP=189 MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPG AFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLE KPNSSVAAKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKV ALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAK VEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNY QLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLA ERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQ TEGYQHVNVTDLTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYE LFRGTPLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEG GNQNKVKSMANQLLAKFEESTRNPSLMKQEKKSPSGFHFHPSHLRTVHPQLTVGKVSSGIGAAAEVLVNLYMNDHRPKAQATSPDLESMR KSFPLNLGGSDTCYFCKKRVYVMERLSAEGHFFHRECFRCSICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRRAELKQQREEE -------------------------------------------------------------- >41366_41366_5_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000537344_length(transcript)=3674nt_BP=734nt GCCGTCGGGATGGAGGTGAGAAGACGGCCGTGACGCGCGCCCGCGGGGCCCCCTGCACCCCCAGCAGCCCACAGCGCTCCCTGCCCCCCT CCCCCGCAGCAGCGGGCCTTGCCGTCGAGTGACAGCGGCCTGGGGGGGCAGGGGGGGCGGGGGCGGCCGGATCAGCGATGCCGGCGGGCA TGACGAAGCATGGCTCCCGCTCCACCAGCTCGCTGCCGCCCGAGCCCATGGAGATCGTGCGCAGCAAGGCGTGCTCTCGGCGGGTCCGCC TCAACGTCGGGGGGCTGGCGCACGAGGTACTCTGGCGTACCCTGGACCGCCTGCCCCGCACGCGGCTGGGCAAGCTCCGCGACTGCAACA CGCACGACTCGCTGCTCGAGGTGTGCGATGACTACAGCCTCGACGACAACGAGTACTTCTTTGACCGCCACCCGGGCGCCTTCACCTCCA TCCTCAACTTCTACCGCACTGGGCGACTGCACATGATGGAGGAGATGTGCGCGCTCAGCTTCAGCCAAGAGCTCGACTACTGGGGCATCG ACGAGATCTACCTGGAGTCCTGCTGCCAGGCCCGCTACCACCAGAAGAAAGAGCAGATGAACGAGGAGCTCAAGCGTGAGGCCGAGACCC TACGGGAGCGGGAAGGCGAGGAGTTCGATAACACGTGCTGCGCAGAGAAGAGGAAAAAACTCTGGGACCTACTGGAGAAGCCCAATTCCT CTGTGGCTGCCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCG TGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGA AGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGG GAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAAT TTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAA GAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTA GTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGG ACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGC TGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCT TAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGC GGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTG GCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTC TCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACC TCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGG TGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACC AGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCA ACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGA CCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCA CCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATC TCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCA CCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACA AAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGGAAAAGAAGTCACCTT CAGGGTTCCATTTTCATCCCAGCCATTTGAGAACAGTGCATCCTCAGCTGACGGTAGGGAAAGTGTCCAGCGGAATAGGGGCTGCAGCTG AAGTCCTGGTCAATCTGTACATGAATGATCACAGACCTAAGGCCCAGGCCACCTCTCCAGACCTGGAATCTATGCGAAAGTCATTTCCCC TTAACCTGGGAGGCAGCGACACGTGTTACTTCTGTAAGAAACGTGTGTACGTGATGGAACGGCTGAGCGCCGAGGGCCACTTCTTCCACC GGGAGTGTTTCCGCTGCAGCATCTGTGCCACCACCTTGCGCCTGGCCGCCTACACCTTTGACTGCGATGAAGGCAAATTTTACTGCAAGC CTCACTTCATTCACTGTAAAACCAATAGCAAACAACGGAAGAGACGGGCAGAGTTGAAGCAACAAAGAGAGGAGGAGGCAACATGGCAAG AGCAGGAAGCCCCTCGGAGAGACACTCCCACCGAAAGTTCTTGCGCAGTGGCCGCCATTGGCACCCTGGAAGGCAGCCCCCCAGTTCATT TCAGCCTTCCAGTGCTACACCCACTTCTTGGCTGACACACTTCTGCTCTAAGGTGACTGGTTTTCTTGCCAATTTTCAAAGAGTGGTACT AACCCCCAACCCGCTTTCCGCACCCCGTCCTCTCCGCCAGCAGTACTGGTTGCACTAACTGTGAGTGTCTTGCATACTGATGGACTCATT TGGTGGCATGGTTGGCTAACAGCATGGCGGGGGGTGTTCAGCTTGAGACCCATGCCTGTGTTCATTTCCCATGGAGCTGGCAGCCTGGTC TACCCCAAGTGCATGCCCCGCCTCTCCTCTCTCCCTTGGGTCTGCCTGCGTGCATGCTTCTCCAGTTGCGTCTGCGAAGCTACCTACTTT >41366_41366_5_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000537344_length(amino acids)=1035AA_BP=189 MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPG AFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLE KPNSSVAAKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKV ALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAK VEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNY QLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLA ERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQ TEGYQHVNVTDLTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYE LFRGTPLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEG GNQNKVKSMANQLLAKFEESTRNPSLMKQEKKSPSGFHFHPSHLRTVHPQLTVGKVSSGIGAAAEVLVNLYMNDHRPKAQATSPDLESMR KSFPLNLGGSDTCYFCKKRVYVMERLSAEGHFFHRECFRCSICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRRAELKQQREEE -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for KCNB1-MICAL2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for KCNB1-MICAL2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | KCNB1 | Q14721 | DB06637 | Dalfampridine | Antagonist | Small molecule | Approved |
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Related Diseases for KCNB1-MICAL2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | KCNB1 | C4015119 | EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 26 | 3 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | KCNB1 | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
Hgene | KCNB1 | C0036341 | Schizophrenia | 1 | CTD_human |